NSWO Dutch year in review 2019/2020

NSWO DUTCH YEAR IN REVIEW 2019/2020

NEDERLANDSE VERENIGING VOOR SLAAP/WAAK-ONDERZOEK (NSWO) / DUTCH SOCIETY FOR SLEEP/WAKE RESEARCH

NSWO DUTCH YEAR IN REVIEW 2019/2020

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Content In memoriam

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Preface

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Events 2019/2020

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Short

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Awards and Q & A with the winner of the thesis award

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Hora est!

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Dutch doctoral dissertations Dutch year in review 2019/2020

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sleep mechanisms – sleep & cognition – circadian clock – sleep across the life span – sleep diagnostics & technology – insomnia – narcolepsy & hypersomnia – sleep apnea – dental sleep medicine – parasomnias & sleep related movement disorders – sleep & physical health – sleep & mental health Booklist

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NSWO Board Y.D. van der Werf (president) – A.G.Y. Kurvers (secretary) – E. Verwijk (treasurer) – A.I. Luik (chair scientific committee) – K. van Rijn (chair PR committee) – N. Antypa (chair education committee) – J. Gool (chair young scientist committee) Scientific committee A.I. Luik - P. Meerlo - J. Verbraecken - S. Overeem - J. Kamphuis – E. Møst - M. van Veen – F. van Oosterhout Cover photo: Oscar Bos and Floor van Oosterhout

In memoriam - Dr. Hans L. Hamburger

Hans was an inspiring neurologist and an advocate of sleep care and sleep research.

Moreover, Hans was a member of the NSWO board since 2006, and has chaired the NSWO for six years, until 2016. In that position he was the face of our sleep society and took the role of front man with vivid passion. He had a strong and tireless profile in the media, communicated with policy makers and within the assembly of the European sleep societies.

As one of the initiators of the textbook ‘Slaap en Slaapstoornissen’ he was involved in the educational curriculum for somnologists in the Netherlands and Belgium; in cooperation with the sister societies in Belgium and the United Kingdom, the BASS and the BSS, he was a founder of the International Sleep Medicine Course which is now organized yearly and alternating between these three countries. He was one of the founders of ‘SLAAP’, which nowadays has become the national conference to visit for all sleep professionals, whether working in the clinic or in fundamental and applied sleep science. He was a proponent of the participation of young researchers in the NSWO and arranged the establishment of the Young Scientists Committee.

The NSWO board was proud to appoint Hans an honorary member of the NSWO during the Autumn symposium in October 2020 (see photo).

We will remember an exceptional and passionate man, with a strong personality and a warm heart for somnology and for the NSWO.

On behalf of the board and committees of the NSWO, Prof. Ysbrand van der Werf - chairman NSWO

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Preface Dear members, The past year has brought many inconveniences and has changed the way in which many of us work. One, albeit bleak, positive effect has nevertheless been an awareness of the importance of our day to day rhythms and the maintenance of our sleep among the public and professionals alike. 'Sleep in times of COVID19' is now a topic of research and sleepcare, and many media have covered the effect of infection, lockdown and curfew on sleep health.

This past year has also witnessed the sad passing of our former President, Hans L. Hamburger; you will find the In Memoriam on the previous page.

The next installment of the national Sleep conference is planned for 25/26 November 2021, in blended or online form. Preparations for the ISMC that we will host in 2022 are underway.

Despite circumstances, the work continues: we have organized the NSWO member meetings, the spring and autumn symposium online, with unprecedented attendance. On Friday 23rd April 2021, the young sleep scientist committee will host the Spring meeting in collaboration with the Amsterdam Sleep and Memory Lab of dr.

Lucia Talamini. We hope to see you all there in virtual presence.

Ysbrand D. van der Werf President NSWO

It is good to see that Dutch sleep care and research is thriving, judging by the enormous productivity and output that you will encounter in this overview. We hope to continue to collaborate, discover and one day soon meet again.

All the best,

EVENTS IN 2019/2020 The NSWO looks back at four inspiring meetings on sleep/wake research in the past two years. On June 14, 2019, the NSWO/BASS Spring Symposium was traditionally hosted by the Center for Sleep Medicine in Kempenhaeghe (Heeze).

Later that year, the NSWO and SVNL were proudly organizing the bi-annual national sleep conference SLAAP2019 in Conference hotel ‘De Heerlickheijd’ (Ermelo), November 14/15, 2019. Two days of inspiring sleep talks and workshops, with three parallel sessions, ranging from fundamental to clinical sleep research topics. With close to 500 visitors (scientists, clinicians, sleep technicians, psychologists etc.) this edition was even more popular than the previous editions of 2016 and 2017. The ‘data blitz’ - in which young scientists were sharply pitching their research - invited the attendees at the poster session. In line with the NSWO tradition, the yearly Piet Visser award for the best poster and the bi-annual Hilbert Kamphuisen award for the best PhD thesis were conferred.

Contacts with newly met colleagues were explored any further during the conference dinner with live music, which for some continued at the dance floor, whereas others remained faithful to their profession and fell in a satisfying sleep ;).

Then covid-19 troubled any live gathering and we had to improvise, but the young scientist committee managed to organize the NSWO Spring Symposium (online) on April 23, 2020, which was hosted by sleep researchers of Rotterdam Erasmus MC. Topic: Sleep epidemiology meets chronobiology.

Sleep researchers were able to find each other again online at the NSWO Autumn Symposium, October 30, 2020 (online) Topic: New ways to sleep better? and apart from good attendance, there was an overwhelming amount of posters received, which were discussed in virtual break-out rooms.

We look forward to inspiring meetings in the future. Be aware, SLAAP2021 is in the agenda again at the end of this year, November 25/26, 2021: save the date!

SLAAP2021 November 25/26, 2021 Save the date!

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How REM sleep impacts on your emotions A good night sleep usually is beneficial for downregulation of emotional tensions that resulted from frightening or shameful experiences. A new day, a new beginning. But not in people suffering from insomnia.

In a series of experiments and publications, Rick Wassing exposed participants to distressing self-conscious emotions – for instance by letting them listen to their own, often embarrassing, out-of-tune karaoke singing.

As measured by functional MRI, such experiences immediately activate the amygdala of the limbic system. Using targeted memory re-activation with odors tagged to the self-conscious emotional stimulus, the researchers then aimed to reactivate the emotional memories during sleep. The next morning, they again measured the response of the amygdala. The results showed two important findings. First, when the emotional memory was reactivated during sound REM sleep, the emotion was less distressful when recalled than when it was first experienced and the amygdala responded much less; brain circuits had adapted overnight. But secondly, if the emotional memory was reactivated during restless REM sleep (fragmented by interrupting arousals and awakenings), experiences were strikingly different next morning. In fact, their amygdala showed insufficiently dampened activity. The results show that overnight amygdala adaptation

fails proportionally to the restlessness of REM sleep.

In conclusion: for the processing of emotional experiences, stable REM sleep seems important.

REM sleep fragmentation is characteristic for people suffering from insomnia, polysomnography typically shows increased cortical arousals.

Thus, the findings shed new light on perpetuation of hyperarousal in insomnia disorder, which is also relevant for posttraumatic stress disorder, anxiety, and depression.

The findings were published in Current Biology in July 2019, and related studies in Brain and Sleep.

What can we learn from starling sleep?

Much of what we know about sleep is from research in mammals; mostly nocturnal species, and often under strict laboratory conditions.

Interestingly, avian sleep - as measured in controlled indoor conditions - shares key sleep features with mammalian sleep, including the presence of REM sleep and NREM sleep, although the proportion of REM sleep per total sleep time is much lower in birds than in mammals.

Researchers from the university of Groningen, in collaboration with colleagues in Germany (Max Planck institute) and Switzerland (University of Zurich), questioned how birds cope with the variations in environmental conditions over the year. Notably, no data on sleep in freely moving birds

were available yet. Using miniature electroencephalogram (EEG) data loggers, they managed to measure sleep in European starlings that were housed together in a large outdoor enclosure with natural temperature and light. Under these semi-natural conditions, the starling sleep pattern shows a striking variation across the annual cycle.

With only circa 7.5h/night of NREM sleep during summer, starlings have five hours less sleep during summer nights as compared to the 12.5h/night NREM sleep in winter. The birds showed a compensatory increase of mid-day naps during summertime, where naps in wintertime are rare. As could be expected from this sleep behaviour, EEG spectral power analyses confirmed that the starlings live under increasing sleep pressure when days lengthen in summer. Furthermore, starling sleep is affected by the moon. It is striking that during full-moon nights, starlings sleep approximately two hours less than usual. REM sleep made up on average only 1.3% of total sleep time, but the proportional amounts still revealed some seasonal variation, which can be at the base for further studies and discussion on the function of REM sleep. This pioneering avian study convincingly shows that environmental factors have a major impact on the organization of sleep and wakefulness.

The findings were published in Current Biology in March 2020.

Gert Jan Lammers professor by special appointment of Neurology - May 1, 2020 The title of his chair is ‘Sleep disorders, in particular narcolepsy and related vigilance disturbances’ The current appointment is the first in the Netherlands dedicated to Sleep Medicine.

Gert Jan Lammers is medical director of the Sleep-Wake Centre of SEIN (Heemstede, Zwolle, Groningen), - which has been designated as a center of expertise for narcolepsy and related disorders - and is also affiliated with the department of Neurology of the LUMC. He is co-founder and former president of the European Narcolepsy Network (EU-NN) and he is the chair of the Dutch Society for Sleep Medicine (SVNL).

Gert Jan was involved in the discovery that narcolepsy is caused by a deficiency of hypocretin-producing cells in the brain. His current research line focuses on follow-up questions. Topics are: Do the hypocretin cells disappear due to an autoimmune reaction? What is the physiological function of hypocretin beyond sleep(regulation)? What is

the best way to treat narcolepsy? What do we learn from the discoveries related to narcolepsy and the role of hypocretin, and can we use the knowledge to improve treatment of other sleep disorders?

Gert Jan Lammers favors a multidisciplinary approach in the treatment of sleep disorders. In the current bachelor’s and master’s courses in medicine there is little attention for healthy sleep as part of a healthy lifestyle, nor for sleep disorders, their recognition, prevention and treatment. Part of the teaching assignment is to expand the educational offer in the field of sleep and sleep medicine in the curriculum of the LUMC.

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A multi million grant to keep the biological clock healthy The BioClock consortium will receive a 9.7 million euro research grant. It is one of the projects that receive funding within the program of the Dutch National Research Agenda of the Dutch National Research Council (NWO), for which the public could submit questions.

The goal of the BioClock consortium is to restore and preserve the health of the biological clock. The plans cover the society as a whole: from human health and disease to the natural environment and protection of biodiversity. Topics such as the health effects of shift work, the integration of the biological clock into the educational system, optimal timing of cancer immunotherapy and flu vaccinations, chronotherapy for depression, and the consequences of light pollution on insects and other light-sensitive animals are all covered in the six-year research program.

With the biological clock at the center, the partners from the consortium will jointly develop strategies to contribute to a sustainable future for our planet and its inhabitants. The project leader is Joke Meijer, professor of neurophysiology at the LUMC. In addition to eight other universities, the research consortium consists of dozens of members from the public and

semi-public sectors and industry: from RIVM to municipalities and from environmental organizations to occupational health services.

Sleep in the Netherlands: Data from over 200,000 persons Including more than 1% of the Dutch population, this is an eye-catching paper in the current ‘year-in-review 2019/2020’. It all started when in 2015 the Dutch Brain Foundation ‘De Hersenstichting’ invited a group of Dutch sleep researchers to talk about the epidemiology of sleep. Around the table discussion raised basic questions concerning sleep behaviour within the general population; What do we actually know about normative values of sleep parameters such as sleep duration across ages?

The idea was born to perform an individual participant descriptive meta-analysis of all sleep studies conducted in the general population of the Netherlands. Starting the systematic literature search, 42 such studies were found, all had collected sleep data in well-defined source populations. Next, principal investigators had to be contacted and persuaded to share their data.

Ultimately, data from 200,358 per-

sons aged 1 to 100 years from 34 studies in the Netherlands were included for analysis. A unique project!

Sleep behaviour estimates were compared with large registries from the UK (471,759 people, 40–69 years) and USA (409,617 people, ≥18 years).

The results show that in the adult population, 1 out of 4 people sleeps less than the age-recommended hours of sleep. About 6% sleeps less than 6 hours, which is generally considered as a threshold indicative for chronic sleep deprivation. Of note, more than half of adolescents have a total sleep time of less than the recommended 8-10 hours, and in this age group, 18% report daytime sleepiness. Insomnia symptoms were most frequent in people spending ≥9 h in bed. Comparison with the UK and USA databases showed that the total sleep time was similar across countries, but insomnia symptoms were up to 2.9 times higher in the USA. This study provides valuable age- and sex-specific reference charts for sleep duration and efficiency which can help guide health practitioners and patients about the typical sleep duration at each age with concordant personalized advice on sleep practices.

The findings were published in Nat Hum Behav in November 2020.

Sandra Kooij professor by special appointment – June 1, 2020 The title of her chair is ‘Attention deficit hyperactivity disorder (ADHD) within adults’ and is established on behalf of Parnassia Group in the Department of Psychiatry at Amsterdam University Medical Center.

Sandra Kooij is a psychiatrist and head of the Expertise Center for Adult ADHD at PsyQ, and is founder of the Knowledge Center for Adult ADHD. Also, she is chair and founder of the European Network Adult ADHD and the international DIVA (Diagnostic Interview for ADHD) Foundation.

Sandra Kooij has expertise in research on diagnostics and treatment of ADHD in adults since 1995 and is also strongly involved in education of mental health care professionals in assessment and treatment of ADHD. She has special research interest in the relationship between ADHD and sleeping problems, including ‘delayed sleep phase disorder’. Other research topics include the treatment of ADHD in older people as well as

hormonal mood changes during the lifespan in women with ADHD. “ADHD and sleep loss usually come together and reinforce each other’s severity. Sleep loss has consequences that look like ADHD symptoms: lack of concentration, worse memory, irritability, craving for carbohydrates, and obesity.”

Is ADHD in fact a sleep disorder? Or is the biological clock behind both problems? Can treatment of sleep disorders improve ADHD symptoms? Sandra Kooij aims to develop new effective treatment options for adults with ADHD.

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Awards, in line with the NSWO traditions

AND THE WINNER IS...

Piet Visser Poster award Yearly awarded at the best poster at the Autumn Symposium SLAAP2019: Thom Lysen – Neurobiological correlates of sleep in a population-based cohort Autumn Symposium 2020 (online): João Patriota - Closed loop acoustic neurostimulation du- ring sleep: targeting theta waves.

Public poster award Autumn Symposium 2020 (online): Desi Kocevska - Are children genetically predisposed to poor sleep? A polygenic risk score study in the general pediatric population.

Hilbert Kamphuisen Thesis award: Bi-annually awarded to the best PhD thesis.

Autumn Symposium 2020 (online): Tessa Blanken.

Changing perspectives on insomnia and depression: From symptoms to system.

Q & A with Tessa Blanken - winner of the Hilbert Kamphuisen Thesis award What is your thesis about?

My thesis consisted of two parts. In the first part we set-out to investigate the heterogeneity in insomnia disorder and see whether we could identify different subtypes of insomnia disorder. We collected data via the online platform of the Netherlands Sleep Registry and looked at many characteristics: not only sleep-related, but also personality traits, life history events, to what extent people experience happiness, and so on. Using latent class analysis, we found five specific subtypes of insomnia that we then compared on clinical outcomes and potential biomarkers. In the second part of my thesis, we studied the link between insomnia and depression from a new perspective, that is, as a system of symptoms – by developing new network analyses. By changing our perspective, from single symptoms to complex systems, we can learn a lot about the pathophysiology of both insomnia and depression- and their interplay.

What hidden talent did you discover in yourself during your PhD? I simply love struggling with data, models and computer analyses, that’s why I studied ‘Psychological Methods’ (University of Amsterdam). But what I really enjoyed most in the PhD projects, was the conversations with all different people, from clinicians to neurobiology experts and brain researchers, who shared their views on the topic of ‘sleep’ with me. One topic, yet so many people and so many views. This was inspiring. At the same time it sometimes felt frightening too, as I felt I was entering a whole new world where I did not always speak the same language. However, through these conversations I learnt a lot and it is all these different perspectives that I value very much.

What was your biggest struggle or disappointment during your PhD? I had to train my mindset… I was trained to do research projects, but as an undergraduate you always find a solution to finish up and go on after 6 months - when a course is due. But now it was different: in the subtyping study for example, we had to go through the models again and again and again, to reach a good level of confidence and come up with a trustworthy answer to the research question. Often the details took so much time, that sometimes I just wanted to move on to the next project. (But for sure, when looking back I am happy we conducted all these steps so thoroughly!).

What would you say to young researchers who are about to start a PhD? In conversations I had as a PhD and still have now with PhD students, sometimes already after the first year people ask: “How about your output? Have you started writing yet?”. Looking back, I’d like to say to myself (and others) that it’s important to keep in mind that a PhD project has different phases. And different phases have different functions. I spent the first year mostly reading and talking about the topic. At the time, I could worry whether I was making enough progress, but looking back I see I benefited a lot from this first year later on in my PhD. So I’d say: a don’t worry too much too soon about output, as a PhD project will have different phases, and they all contribute to your PhD as a whole.

What are your dreams for the future?

Currently I have a position at the University of Amsterdam, where I am a co-founder of the ‘Science versus Corona’-platform. This initiative was founded in March 2020 to unite experts across disciplines and help researchers from all over the world with coronavirus related data analyses. Furthermore, I received a grant from the BIAL foundation, which starts in September 2021 and allows me to work on the integration of brain and behavior via network analyses.

The combination of advanced data analyses ánd societal relevance seems to be the perfect fit for me. So, lots of new plans in the field of insomnia and depression for the near future!

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DUTCH DOCTORAL DISSERTATIONS Chapter 7

PATIENT-REPORTED OUTCOME MEASURES (PROMS) IN CLINICAL PRACTICE FOR PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

Late side effects of short course preoperative radiotherapy combined Th. de Jong, W. Aalbers, E. Timmerman, L. Keijzer and E. Meilink

HORA EST!

A NEW-GENERATION DEVICE FOR PATIENTS WITH POSITIONAL OBSTRUCTIVE SLEEP APNEA

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SLEEP AND RISK OF NEURODEGENERATIVE DISEASE A population-based approach

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NSWO DUTCH YEAR IN REVIEW 2019/2020

IT’S ABOUT TIME Circadian Rhythm Rhythm Circadian and Metabolism Metabolism and

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Peer-reviewed publications on sleep/wake-research in The Netherlands

S L E E P M E C H ANIS MS

DUTCH YEAR IN REVIEW 2019/2020 The mystery of sleep All animals, including humans, spend a large part of their life asleep. While progress is made on the genetic and molecular underpinnings of sleep; its functions remain a matter of debate. Sleep may support many different processes in the body, but most theories still revolve around the idea that sleep is essential for maintenance and plasticity of the brain. Among other, sleep appears to regulate connectivity between nerve cells and brain regions, which ultimately is crucial for the functional output of the brain in terms of behaviour and cognitive function. In agreement with this, various new studies listed below confirm that not getting enough sleep has a major impact on our performance, from an initial subtle decrease in alertness and an inability to properly drive a car, to learning deficits and impaired memory.

While much of what we learn about sleep is based on studies in humans or laboratory rodents under strictly controlled conditions, comparative studies in other, non-model species under more natural conditions can provide unexpected results and novel insights. New studies in birds, for example, show that the amount of sleep can vary dramatically across the seasons or in response to the phase of the moon. And some birds apparently can do without REM sleep. Such findings bring us back to the very basic questions regarding sleep regulation and sleep function that makes one realize sleep in many ways is still a mystery. How come we think humans need eight hours of consolidated sleep, every night again, whereas other species display enormous phenotypic plasticity in their sleep? What is driving the need for sleep and how is that different between individuals and species? And what exactly is REM sleep, how is it regulated, and what is it for?

Peter Meerlo, PhD - University of Groningen, Groningen. p.meerlo@rug.nl

THE BIOLOGY OF SLEEP Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, Beaumont RN, Bechtold DA, Bowden J, Cade BE, Garaulet M, Kyle SD, Little MA, Loudon AS, Luik AI, Scheer FAJL, Spiegelhalder K, Tyrrell J, Gottlieb DJ, Tiemeier H, Ray DW, Purcell SM, Frayling TM, Redline S, Lawlor DA, Rutter MK, Weedon MN, Saxena R. Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun. 2019.

El Aidy S, Bolsius YG, Raven F, Havekes R. A brief period of sleep deprivation leads to subtle changes in mouse gut microbiota. J Sleep Res. 2020.

Goelema MS, Regis M, Haakma R, van den Heuvel ER, Markopoulos P, Overeem S. Determinants of perceived sleep quality in normal sleepers. Behav Sleep Med. 2019.

Jones SE, van Hees VT, Mazzotti DR, Marques-Vidal P, Sabia S, van der Spek A, Dashti HS, Engmann J, Kocevska D, Tyrrell J, Beaumont RN, Hillsdon M, Ruth KS, Tuke MA, Yaghootkar H, Sharp SA, Ji Y, Harrison JW, Freathy RM, Murray A, Luik AI, Amin N, Lane JM, Saxena R, Rutter MK, Tiemeier H, Kutalik Z, Kumari M, Frayling TM, Weedon MN, Gehrman PR, Wood AR. Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Nat Commun. 2019.

Noordam R, Bos MM, Wang H, ……., Rao DC, van Heemst D, Redline S. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat Commun. 2019. van der Meij J, Rattenborg NC, Beckers GJL. Divergent neuronal activity patterns in the avian hippocampus and nidopallium. Eur J Neurosci. 2020. van der Meij J, Martinez-Gonzalez D, Beckers GJL, Rattenborg NC. Neurophysiology of Avian Sleep: Comparing Natural Sleep and Isoflurane Anesthesia. Front Neurosci. 2019. van der Meij J, Martinez-Gonzalez D, Beckers GJL, Rattenborg NC. Intra”cortical” activity during avian non-REM and REM sleep: variant and invariant traits between birds and mammals. Sleep. 2019. van Hasselt SJ, Mekenkamp GJ, Komdeur J, Allocca G, Vyssotski AL, Piersma T, Rattenborg NC, Meerlo P. Seasonal variation in sleep homeostasis in migratory geese: a rebound of NREM sleep following sleep deprivation in summer but not in winter. Sleep. 2020. van Hasselt SJ, Rusche M, Vyssotski AL, Verhulst S, Rattenborg NC, Meerlo P. Sleep Time in the European Starling Is Strongly Affected by Night Length and Moon Phase. Curr Biol. 2020.

van Hasselt SJ, Rusche M, Vyssotski AL, Verhulst S, Rattenborg NC, Meerlo P. The European starling (Sturnus vulgaris) shows signs of NREM sleep homeostasis but has very little REM sleep and no REM sleep homeostasis. Sleep. 2020.

Rattenborg NC, van der Meij J, Beckers GJL, Lesku JA. Local Aspects of Avian Non-REM and REM Sleep. Front Neurosci. 2019.

SLEEP & BRAIN Amini M, Saboory E, Derafshpour L, Fakhari A, Wu JC, Bruggeman R, Asgharzadeh F, Ahmadalipour A. The impact of sleep deprivation on sexual behaviors and FAAH expression in the prefrontal cortex of male rats. Neurosci Lett. 2020.

Elvsåshagen T, Mutsaerts HJ, Zak N, Norbom LB, Quraishi SH, Pedersen PØ, Malt UF, Westlye LT, van Someren EJ, Bjørnerud A, Groote IR. Cerebral blood flow changes after a day of wake, sleep, and sleep deprivation. Neuroimage. 2019.

Górska U, Binder M. Low and medium frequency auditory steady-state responses decrease during NREM sleep. Int J Psychophysiol. 2019.

Havekes R, Aton SJ. Impacts of Sleep Loss versus Waking Experience on Brain Plasticity: Parallel or Orthogonal? Trends Neurosci. 2020.

Kocevska D, Tiemeier H, Lysen TS, de Groot M, Muetzel RL, Van Someren EJW, Ikram MA, Vernooij MW, Luik AI. The prospective association of objectively measured sleep and cerebral white matter microstructure in middle-aged and older persons. Sleep. 2019.

Leenaars CHC, Drinkenburg WHP, Nolten C, Dematteis M, Joosten RNJMA, Feenstra MGP, De Vries RBM. Sleep and Microdialysis: An Experiment and a Systematic Review of Histamine and Several Amino Acids. J Circadian Rhythms. 2019.

Lysen TS, Zonneveld HI, Muetzel RL, Ikram MA, Luik AI, Vernooij MW, Tiemeier H. Sleep and resting-state functional magnetic resonance imaging connectivity in middle-aged adults and the elderly: A population-based study. J Sleep Res. 2020.

Navarro-Lobato I, Genzel L. The up and down of sleep: From molecules to electrophysiology. Neurobiol Learn Mem. 2019.

Ngo HV, Fell J, Staresina B. Sleep spindles mediate hippocampal-neocortical coupling during long-duration ripples. Elife. 2020.

Petit G, Cebolla AM, Fattinger S, Petieau M, Summerer L, Cheron G, Huber R. Local sleep-like events during wakefulness and their rela-

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tionship to decreased alertness in astronauts on ISS. NPJ Microgravity. 2019.

Ramaswamy SM, Weerink MAS, Struys MMRF, Nagaraj SB. Dexmedetomidine Induced Deep Sedation Mimics Non-Rapid Eye Movement Stage 3 Sleep: Large Scale Validation using Machine Learning.

Sleep. 2020.

Raven F, Meerlo P, Van der Zee EA, Abel T, Havekes R. A brief period of sleep deprivation causes spine loss in the dentate gyrus of mice.

Neurobiol Learn Mem. 2019.

SLEEP & COGNITION

Sikkens T, Bosman CA, Olcese U. The Role of Top-Down Modulation in Shaping Sensory Processing Across Brain States: Implications for Consciousness. Front Syst Neurosci. 2019.

SLEEP & COGNITION Ashton JE, Harrington MO, Langthorne D, Ngo HV, Cairney SA. Sleep deprivation induces fragmented memory loss. Learn Mem. 2020.

Barner C, Altgassen M, Born J, Diekelmann S. Effects of sleep on the realization of complex plans. J Sleep Res. 2019.

Cross ZR, Santamaria A, Corcoran AW, Chatburn A, Alday PM, Coussens S, Kohler MJ. Individual alpha frequency modulates sleep-related emotional memory consolidation. Neuropsychologia. 2020.

De Zeeuw CI, Canto CB. Sleep deprivation directly following eyeblinkconditioning impairs memory consolidation. Neurobiol Learn Mem. 2020.

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Stevner ABA, Vidaurre D, Cabral J, Rapuano K, Nielsen SFV, Tagliazucchi E, Laufs H, Vuust P, Deco G, Woolrich MW, Van Someren E, Kringelbach ML. Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep. Nat Commun. 2019. van der Goot E, Bruinenberg VM, Hormann FM, Eisel ULM, van Spronsen FJ, Van der Zee EA. Hippocampal microglia modifications in C57Bl/6 Pah enu2 and BTBR Pahenu2 phenylketonuria (PKU) mice depend on the genetic background, irrespective of disturbed sleep patterns.

Neurobiol Learn Mem. 2019. van Leeuwen KG, Sun H, Tabaeizadeh M, Struck AF, van Putten MJAM, Westover MB. Detecting abnormal electroencephalograms using deep convolutional networks. Clin Neurophysiol. 2019.

tion during sleep improves consolidation of reward-related memory information in healthy children but not in children with attention-deficit hyperactivity disorder. Sleep. 2020.

Raven F, Heckman PRA, Havekes R, Meerlo P. Sleep deprivation-induced impairment of memory consolidation is not mediated by glucocorticoid stress hormones. J Sleep Res. 2020.

Raven F, Bolsius YG, van Renssen LV, Meijer EL, van der Zee EA, Meerlo P, Havekes R. Elucidating the role of protein synthesis in hippocampus-dependent memory consolidation across the day and night. Eur J Neurosci. 2020. van Dijk DM, van Rhenen W, Murre JMJ, Verwijk E. Cognitive functioning, sleep quality, and work performance in non-clinical burnout: The role of working memory. PLoS One. 2020.

Forcato C, Klinzing JG, Carbone J, Radloff M, Weber FD, Born J, Diekelmann S. Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans.

Commun Biol. 2020.

van Peer JM, Gladwin TE, Nieuwenhuys A. Effects of threat and sleep deprivation on action tendencies and response inhibition. Emotion.

2019.

Heckman PRA, Roig Kuhn F, Meerlo P, Havekes R. A brief period of sleep deprivation negatively impacts the acquisition, consolidation, and retrieval of object-location memories. Neurobiol Learn Mem. 2020.

Vermeulen MCM, Van der Heijden KB, Swaab H, Van Someren EJW. Sleep spindle characteristics and sleep architecture are associated with learning of executive functions in school-age children. J Sleep Res. 2019.

Heckman PRA, Roig Kuhn F, Raven F, Bolsius YG, Prickaerts J, Meerlo P, Havekes R. Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation. Synapse. 2020.

Vinckenbosch FRJ, Vermeeren A, Verster JC, Ramaekers JG, Vuurman EF. Validating lane drifts as a predictive measure of drug or sleepiness induced driving impairment. Psychopharmacology (Berl). 2020.

Prehn-Kristensen A, Ngo HV, Lentfer L, Berghäuser J, Brandes L, Schulze L, Göder R, Mölle M, Baving L. Acoustic closed-loop stimula-

Zenses AK, Lenaert B, Peigneux P, Beckers T, Boddez Y. Sleep deprivation increases threat beliefs in human fear conditioning. J Sleep Res. 2020.

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The Netherlands – a top player in the field of Chronobiology In a country as small as the Netherlands, it is quite remarkable how popular the field of Chronobiology is. The popularity will definitely increase over the upcoming years, and this is not only due to the fact that Chronobiology was awarded the Nobel prize in Physiology or Medicine in 2017.

The research line of Chronobiology in the Netherlands was initiated by Serge Daan (1940-2018), the scientific ‘son’ of the godfathers in chronobiology: Professors Aschoff and Pittendrigh. Together with Pittendrigh, he wrote the ‘bible of chronobiology’ in 1976; five conceptual papers that even today are still worthwhile reading (J.Comp.Physiol. A 106(3)). In 1984, together with professors Beersma and Borbély, he published the famous paper describing ‘the two-process model of sleep regulation’ combining the fields of chronobiology and sleep research (Am.J.Physiol. 246).

We are the only country where therapists and researchers regularly exchange ideas about chronotherapy in ‘Chronotherapy Network Netherlands’ (J.Biol.Rhythms 35(3) 2020). Research is of course supported by grants; examples are big European framework programs (e.g.

Braintime, EuClock), and national grants such as On Time. Last but not least, in November 2020 the BioClock consortium with professor Joke Meijer from Leiden in the lead and more than 14 knowledge institutes and 35 companies and societies taking part, was awarded a 9.7 m€ grant to join forces in keeping the biological clock healthy in our modern 24h-society. You will hear more about this field in the future!

Marijke C.M. Gordijn, PhD. Chrono@Work & University of Groningen

CIRCADIAN RHYTHMS Almog A, Buijink MR, Roethler O, Michel S, Meijer JH, Rohling JHT, Garlaschelli D. Uncovering functional signature in neural systems via random matrix theory. PLoS Comput Biol. 2019.

Ananthasubramaniam B, Meijer JH. Regulation of Rest, Rather Than Activity, Underlies Day-Night Activity Differences in Mice. Front Physiol. 2020.

Berendsen M, Boss M, Smits M, Pot GK. Chrono-Nutrition and Diet Quality in Adolescents with Delayed Sleep-Wake Phase Disorder. Nutrients. 2020.

Bierings RAJM, Gordijn MCM, Jansonius NM. Chronotyping glaucoma patients with the Munich ChronoType Questionnaire: A case-control study. PLoS One. 2019.

Cederroth CR, Albrecht U, Bass J, Brown SA, Dyhrfjeld-Johnsen J, Gachon F, Green CB, Hastings MH, Helfrich-Förster C, Hogenesch JB, Lévi F, Loudon A, Lundkvist GB, Meijer JH, Rosbash M, Takahashi JS, Young M, Canlon B. Medicine in the Fourth Dimension. Cell Metab. 2019.

Dashti HS, Merino J, Lane JM, Song Y, Smith CE, Tanaka T, McKeown NM, Tucker C, Sun D, Bartz TM, Li-Gao R, Nisa H, Reutrakul S, Lemaitre RN, Alshehri TM, de Mutsert R, Bazzano L, Qi L, Knutson KL, Psaty BM, Mook-Kanamori DO, Perica VB, Neuhouser ML, Scheer FAJL, Rutter MK, Garaulet M, Saxena R. Genome-wide association study of breakfast skipping links clock regulation with food timing. Am J Clin Nutr. 2019.

Deboer T. Circadian regulation of sleep in mammals. Current Opinion in Physiology. 2020. de Coo IF, van Oosterhout WPJ, Wilbrink LA, van Zwet EW, Ferrari MD, Fronczek R. Chronobiology and Sleep in Cluster Headache. Headache. 2019.

Dikker S, Haegens S, Bevilacqua D, Davidesco I, Wan L, Kaggen L, McClintock J, Chaloner K, Ding M, West T, Poeppel D. Morning brain: Real-world neural evidence that high school class times matter. Soc Cogn Affect Neurosci. 2020.

Farshadi E, van der Horst GTJ, Chaves I. Molecular Links between the Circadian Clock and the Cell Cycle. J Mol Biol. 2020.

Floessner TSE, Boekelman FE, Druiven SJM, de Jong M, Rigter PMF, Beersma DGM, Hut RA. Lifespan is unaffected by size and direction of daily phase shifts in Nasonia, a hymenopteran insect with strong circadian light resetting. J Insect Physiol. 2019.

Italianer MF, Naninck EFG, Roelants JA, van der Horst GTJ, Reiss IKM, Goudoever JBV, Joosten KFM, Chaves I, Vermeulen MJ. Circadian Variation in Human Milk Composition, a Systematic Review. Nutrients. 2020.

Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, Tuke MA, Yaghootkar H, Sharp SA, Jie Y, Thompson WD, Harrison JW, Dawes A, Byrne EM, Tiemeier H, Allebrandt KV, Bowden J, Ray DW, Freathy RM, Murray A, Mazzotti DR, Gehrman PR, Lawlor DA, Frayling TM, Rutter MK, Hinds DA, Saxena R, Weedon MN. Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nat Commun. 2019.

Leenaars CHC, Lucassen MFG, Borger N, Houben E, Kalsbeek A. Social Jet-Lag in Tertiary Students Following a Modern Curriculum with Few Time-Tabled Contact Hours: A Pilot Study. Clocks & Sleep. 2019.

Lok R, van Koningsveld MJ, Gordijn MCM, Beersma DGM, Hut RA. Daytime melatonin and light independently affect human alertness and body temperature. J Pineal Res. 2019.

Lok R, Zeitzer JM. A Temporal Threshold for Distinguishing Off-Wrist from Inactivity Periods: A Retrospective Actigraphy Analysis. Clocks Sleep. 2020.

Lok R, Zerbini G, Gordijn MCM, Beersma DGM, Hut RA. Gold, silver or bronze: circadian variation strongly affects performance in Olympic athletes. Sci Rep. 2020.

Meesters Y, Starreveld D, Verwijk E, Spaans HP, Gordijn MCM. Chronotherapy Network Netherlands (CNN). J Biol Rhythms. 2020.

Menon JML, Nolten C, Achterberg EJM, Joosten RNJMA, Dematteis M, Feenstra MGP, Drinkenburg WHP, Leenaars CHC. Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation - a Systematic Review, Network Meta-analysis, and New Primary Data. J Circadian Rhythms. 2019.

Michel S, Meijer JH. From clock to functional pacemaker. Eur J Neurosci. 2020.

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Montie K, Quaedackers L, Perlitius V, van der Horst E, Vandenbussche N, Overeem S, Pillen S. The impact of delayed sleep phase disorder on adolescents and their family. Sleep Med. 2019.

Kosmadopoulos A, Kervezee L, Boudreau P, Gonzales-Aste F, Vujovic N, Scheer FAJL, Boivin DB. Effects of Shift Work on the Eating Behavior of Police Officers on Patrol. Nutrients. 2020.

Naber WC, Fronczek R, Haan J, Doesborg P, Colwell CS, Ferrari MD, Meijer JH. The biological clock in cluster headache: A review and hypothesis.

Cephalalgia. 2019.

Kervezee L, Cermakian N, Boivin DB. Individual metabolomic signatures of circadian misalignment during simulated night shifts in humans. PLoS Biol. 2019.

Olde Engberink AHO, Huisman J, Michel S, Meijer JH. Brief light exposure at dawn and dusk can encode day-length in the neuronal network of the mammalian circadian pacemaker. FASEB J. 2020.

Loef B, van der Beek AJ, Hulsegge G, van Baarle D, Proper KI. The mediating role of sleep, physical activity, and diet in the association between shift work and respiratory infections. Scand J Work Environ Health. 2020.

Ota SM, Hut R, Riede S, Crosby P, Suchecki D, Meerlo P. Social stress and glucocorticoids alter PERIOD2 rhythmicity in the liver, but not in the suprachiasmatic nucleus. Hormones and Behavior 2020.

Marti AR, Pedersen TT, Wisor JP, Mrdalj J, Holmelid Ø, Patil S, Meerlo P, Bramham CR, Grønli J. Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids. Sci Rep. 2020.

Panagiotou M, Rohling JHT, Deboer T. Sleep Network Deterioration as a Function of Dim-Light-At-Night Exposure Duration in a Mouse Model.

Clocks & Sleep. 2020.

Mentink LJ, Thomas J, Melis RJF, Olde Rikkert MGM, Overeem S, Claassen JAHR. Home-EEG assessment of possible compensatory mechanisms for sleep disruption in highly irregular shift workers - The ANCHOR study.

PLoS One. 2020.

Papatsimpa C, Linnartz JP. Personalized Office Lighting for Circadian Health and Improved Sleep. Sensors (Basel). 2020.

Parkar SG, Kalsbeek A, Cheeseman JF. Potential role for the gut microbiota in modulating host circadian rhythms and metabolic health. Microorganisms. 2019.

Roosendaal J, Jacobs BAW, Pluim D, Rosing H, de Vries N, van Werkhoven E, Nuijen B, Beijnen JH, Huitema ADR, Schellens JHM, Marchetti S. Phase I pharmacological study of continuous chronomodulated capecitabine treatment. Pharm Res. 2020.

Oosterman JE, Wopereis S, Kalsbeek A. The Circadian Clock, Shift Work, and Tissue-Specific Insulin Resistance. Endocrinology. 2020.

Riethmeister V, Matthews RW, Dawson D, de Boer MR, Brouwer S, Bültmann U. Time-of-day and days-on-shift predict increased fatigue over two-week offshore day-shifts. Appl Ergon. 2019.

Thomas J, Overeem S, Dresler M, Kessels RPC, Claassen JAHR. Shift-workrelated sleep disruption and the risk of decline in cognitive function: The CRUISE Study. J Sleep Res. 2020.

Schilperoort M, van den Berg R, Bosmans LA, van Os BW, Dollé MET, Smits NAM, Guichelaar T, van Baarle D, Koemans L, Berbée JFP, Deboer T, Meijer JH, de Vries MR, Vreeken D, van Gils JM, Willems van Dijk K, van Kerkhof LWM, Lutgens E, Biermasz NR, Rensen PCN, Kooijman S. Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden. CETP mice. J Pineal Res. 2020.

Ujma PP, Baudson TG, Bódizs R, Dresler M. The relationship between chronotype and intelligence: the importance of work timing. Sci Rep. 2020.

Schilperoort M, van den Berg R, Dollé MET, van Oostrom CTM, Wagner K, Tambyrajah LL, Wackers P, Deboer T, Hulsegge G, Proper KI, van Steeg H, Roenneberg T, Biermasz NR, Rensen PCN, Kooijman S, van Kerkhof LWM. Time-restricted feeding improves adaptation to chronically alternating light-dark cycles. Sci Rep. 2019.

van Woerkom M. A quasi-experimental study into the effects of naps and therapy glasses on fatigue and well-being. J Nurs Manag. 2020.

Smyk MK, van Luijtelaar G, Huysmans H, Drinkenburg WH. Spike-Wave Discharges and Sleep-Wake States during Circadian Desynchronization: No Effects of Agomelatine upon Re-Entrainment. Neuroscience. 2019. van Soest I, Del Olmo M, Schmal C, Herzel H. Nonlinear phenomena in models of the circadian clock. J R Soc Interface. 2020. van der Vinne V, Tachinardi P, Riede SJ, Akkerman J, Scheepe J, Daan S, Hut RA. Maximising survival by shifting the daily timing of activity. Ecol Lett. 2019.

van de Langenberg D, Vlaanderen JJ, Dolle MET, Handberg A, Vermeulen RCH, van Kerkhof LWM. Plasma sCD36 as non-circadian marker of chronic circadian disturbance in shift workers. PLoS One. 2019.

LIGHT AT NIGHT Cajochen C, Reichert C, Maire M, Schlangen LJM, Schmidt C, Viola AU, Gabel V. Evidence That Homeostatic Sleep Regulation Depends on Ambient Lighting Conditions during Wakefulness. Clocks Sleep. 2019.

Fleury G, Masís-Vargas A, Kalsbeek A. Metabolic Implications of Exposure to Light at Night: Lessons from Animal and Human Studies. Obesity (Silver Spring). 2020.

Huss A, van Wel L, Bogaards L, Vrijkotte T, Wolf L, Hoek G, Vermeulen R. Shedding Some Light in the Dark-A Comparison of Personal Measurements with Satellite-Based Estimates of Exposure to Light at Night among Children in the Netherlands. Environ Health Perspect. 2019

Wynchank D, Bijlenga D, Penninx BW, Lamers F, Beekman AT, Kooij JJS, Verhoeven JE. Delayed sleep-onset and biological age: late sleep-onset is associated with shorter telomere length. Sleep. 2019 Oct 9;42(10):zsz139.

Knufinke M, Fittkau-Koch L, Møst EIS, Kompier MAJ, Nieuwenhuys A. Restricting short-wavelength light in the evening to improve sleep in recreational athletes - A pilot study. Eur J Sport Sci. 2019.

Zerbini G, van der Vinne V, Otto LKM, Monecke S, Kantermann T, Merrow M. Tardiness Increases in Winter: Evidence for Annual Rhythms in Humans.

J Biol Rhythms. 2019.

Masís-Vargas A, Hicks D, Kalsbeek A, Mendoza J. Blue light at night acutely impairs glucose tolerance and increases sugar intake in the diurnal rodent Arvicanthis ansorgei in a sex-dependent manner. Physiol Rep. 2019.

SHIFT WORK

Panagiotou M, Deboer T. Effects of Chronic Dim-light-at-night Exposure on Sleep in Young and Aged Mice. Neuroscience. 2020.

Aarts MPJ, Hartmeyer SL, Morsink K, Kort HSM, de Kort YAW. Can Special Light Glasses Reduce Sleepiness and Improve Sleep of Nightshift Workers? A Placebo-Controlled Explorative Field Study. Clocks Sleep.

2020.

Te Kulve M, Schlangen LJM, van Marken Lichtenbelt WD. Early evening light mitigates sleep compromising physiological and alerting responses to subsequent late evening light. Sci Rep. 2019.

Hulsegge G, Picavet HSJ, van der Beek AJ, Verschuren WMM, Twisk JW, Proper KI. Shift work, chronotype and the risk of cardiometabolic risk factors. Eur J Public Health. 2019.

Ulgezen ZN, Käpylä T, Meerlo P, Spoelstra K, Visser ME, Dominoni DM. The preference and costs of sleeping under light at night in forest and urban great tits. Proc Biol Sci. 2019.

Hulsegge G, Loef B, van Kerkhof LW, Roenneberg T, van der Beek AJ, Proper KI. Shift work, sleep disturbances and social jetlag in healthcare workers. J Sleep Res. 2019.

Xiao Q, Gee G, Jones RR, Jia P, James P, Hale L. Cross-sectional association between outdoor artificial light at night and sleep duration in middle-toolder aged adults: The NIH-AARP Diet and Health Study. Environ Res. 2020.

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Of mice and men: Chronological, biological (and chronobiological?) age and sleep We all age; some of us faster than others. Since sleep research is much focused on the brain this organ is the target of most research investigating sleep and aging. After discovering in the previous years that changes in circadian rhythms in mice and men (and women and all others) do show large similarity, but that changes in sleep can be quite different, there is more a trend visible towards ‘healthy’ aging.

Intervention studies, for better or for worse, concerning the traditional lifestyle changes (diet, exercise), but also newer methods like for instance boosting slow-waves in the EEG with auditory closed-loop stimulation, have been initiated. Next to that there are some interesting initiatives that scratch at the surface of what aging really is. What is chronological age and how does it relate to your biological age, and what can chronobiology (and sleep) add to this? What changes in the brain, and how can it be measured? Thanks to a large cohort of retired individuals that are willing to participate there is a bright future ahead for research on sleep and aging in the Netherlands.

Tom de Boer, PhD - Laboratory for Neurophysiology, Leiden University Medical Center, Leiden.

PEDIATRIC SLEEP Belmon LS, Busch V, van Stralen MM, Stijnman DPM, Hidding LM, Harmsen IA, Chinapaw MJM. Child and Parent Perceived Determinants of Children’s Inadequate Sleep Health. A Concept Mapping Study. Int J Environ Res Public Health. 2020.

Belmon LS, Brasser FB, Busch V, van Stralen MM, Harmsen IA, Chinapaw MJM. Perceived Determinants of Children’s Inadequate Sleep Health. A Concept Mapping Study among Professionals. Int J Environ Res Public Health. 2020.

Belmon LS, van Stralen MM, Busch V, Harmsen IA, Chinapaw MJM. What are the determinants of children’s sleep behavior? A systematic review of longitudinal studies. Sleep Med Rev. 2019.

Derks IPM, Gillespie AN, Kerr JA, Wake M, Jansen PW. Associations of Infant Sleep Duration with Body Composition and Cardiovascular Health to Mid-Adolescence: The PEAS Kids Growth Study. Child Obes. 2019.

Harskamp-van Ginkel MW, Ierodiakonou D, Margetaki K, Vafeiadi M, Karachaliou M, Kogevinas M, Vrijkotte TGM, Chatzi L. Gestational sleep deprivation is associated with higher offspring body mass index and blood pressure. Sleep. 2020.

Harskamp-van Ginkel MW, Chinapaw MJM, Harmsen IA, Anujuo KO, Daams JG, Vrijkotte TGM. Sleep during Infancy and Associations with Childhood Body Composition: A Systematic Review and Narrative Synthesis. Child Obes. 2020.

Harskamp-van Ginkel MW, Kool RE, van Houtum L, Belmon LS, Huss A, Chinapaw MJM, Vrijkotte TGM. Potential determinants during ‘the first 1000 days of life’ of sleep problems in school-aged children. Sleep Med. 2020.

Heida EJ, Lunsing RJ, Brouwer OF, Meiners LC. Melatonin in neuropaediatric MRI: a retrospective study of efficacy in a general hospital setting. Eur J Paediatr Neurol. 2020.

Hulst RY, Pillen S, Voorman JM, Rave N, Visser-Meily JMA, Verschuren O. Sleep health practices and sleep knowledge among healthcare professionals in Dutch paediatric rehabilitation. Child Care Health Dev. 2020.

Komrij NL, van Stralen MM, Busch V, Inhulsen MMR, Koning M, de Jong E, Renders CM. Predictors of Changes in Sleep Duration in Dutch Primary School children: the ChecKid Study. Int J Behav Med. 2020.

Koopman-Verhoeff ME, Mulder RH, Saletin JM, Reiss I, van der Horst GTJ, Felix JF, Carskadon MA, Tiemeier H, Cecil CAM. Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study. J Child Psychol Psychiatry. 2020.

Koopman-Verhoeff ME, van den Dries MA, van Seters JJ, Luijk MPCM, Tiemeier H, Luik AI. Association of Sleep Problems and Melatonin Use in School-aged Children. JAMA Pediatr. 2019.

Koopman-Verhoeff ME, Serdarevic F, Kocevska D, Bodrij FF, MilevaSeitz VR, Reiss I, Hillegers MHJ, Tiemeier H, Cecil CAM, Verhulst FC, Luijk MPCM. Preschool family irregularity and the development of sleep problems in childhood: a longitudinal study. J Child Psychol Psychiatry. 2019.

Mulder TA, Kocevska D, Muetzel RL, Koopman-Verhoeff ME, Hillegers MH, White T, Tiemeier H. Childhood sleep disturbances and white

matter microstructure in preadolescence. J Child Psychol Psychiatry.

2019.

Rensen N, Steur LMH, Wijnen N, van Someren EJW, Kaspers GJL, van Litsenburg RRL. Actigraphic estimates of sleep and the sleep-wake rhythm, and 6-sulfatoxymelatonin levels in healthy Dutch children.

Chronobiol Int. 2020.

Steur LMH, Grootenhuis MA, Terwee CB, Pillen S, Wolters NGJ, Kaspers GJL, van Litsenburg RRL. Psychometric properties and norm scores of the sleep self report in Dutch children. Health Qual Life Outcomes.

2019.

Toorop AA, van der Voorn B, Hollanders JJ, Dijkstra LR, Dolman KM, Heijboer AC, Rotteveel J, Honig A, Finken MJJ. Diurnal rhythmicity in breast-milk glucocorticoids, and infant behavior and sleep at age 3 months. Endocrine. 2020. van Kooten JAMC, Jacobse STW, Heymans MW, de Vries R, Kaspers GJL, van Litsenburg RRL. A metaanalysis of accelerometer sleep outcomes in healthy children based on the Sadeh algorithm: the influence of child and device characteristics.

Sleep. 2020.

Wang L, Jansen W, BoereBoonekamp MM, Vlasblom E, L’Hoir MP, Beltman M, van Grieken A, Raat H. Sleep and body mass index in infancy and early childhood (6-36 mo): a longitudinal study. Pediatr Obes. 2019.

Wei S, Smits MG, Tang X, Kuang L, Meng H, Ni S, Xiao M, Zhou X. Efficacy and safety of melatonin for sleep onset insomnia in children and adolescents: a meta-analysis of randomized controlled trials. Sleep Med. 2020.

SLEEP & AGING Böhmer MN, Oppewal A, Bindels PJE, Tiemeier H, van Someren EJW, Festen DAM. Comparison of sleep-wake rhythms in elderly persons with intellectual disabilities and the general population.

Sleep Med. 2020.

Buijink MR, Olde Engberink AHO, Wit CB, Almog A, Meijer JH, Rohling JHT, Michel S. Aging affects the

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capacity of photoperiodic adaptation downstream from the central molecular clock. J Biol Rhythms. 2020.

Buijink MR, Michel S. A multi-level assessment of the bidirectional relationship between aging and the circadian clock. J Neurochem.

2020.

De Feijter M, Lysen TS, Luik AI. 24-Hour activity rhythms and health in older adults. Sleep Medicine Reports 2020.

Kocevska D, Cremers LGM, Lysen TS, Luik AI, Ikram MA, Vernooij MW, Tiemeier H. Sleep complaints and cerebral white matter: A prospective bidirectional study. J Psychiatr Res. 2019.

Kocevska D, Lysen TS, Dotinga A, >………...< Luik AI, Van Someren EJW, Tiemeier H. Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis. Nat Hum Behav. 2020.

SLEEP DIAGNOSTICS & TECHNOLOGY

Panagiotou M, Deboer T. Chronic high-caloric diet accentuates age-induced sleep alterations in mice. Behav Brain Res. 2019.

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Stenveld F, Bosman S, van Munster BC, Beishuizen SJ, Hempenius L, van der Velde N, Smidt N, de Rooij SE. Melatonin, temazepam and placebo in hospitalized older patients with sleeping problems (MATCH): a study protocol of randomized controlled trial. BMJ Open. 2019.

Sun H, Paixao L, Oliva JT, Goparaju B, Carvalho DZ, van Leeuwen KG, Akeju O, Thomas RJ, Cash SS, Bianchi MT, Westover MB. Brain age from the electroencephalogram of sleep. Neurobiol Aging. 2019.

Thölking TW, Lamers ECT, Olde Rikkert MGM. A guiding nightlight decreases fear of falling and increases sleep quality of communitydwelling older people: A quantitative and qualitative evaluation.

Gerontology. 2020.

Ujma PP, Konrad BN, Simor P, Gombos F, Körmendi J, Steiger A, Dresler M, Bódizs R. Sleep EEG functional connectivity varies with age and sex, but not general intelligence. Neurobiol Aging. 2019.

Ujma PP, Simor P, Steiger A, Dresler M, Bódizs R. Individual slow-wave morphology is a marker of aging. Neurobiol Aging. 2019.

Schneider J, Lewis PA, Koester D, Born J, Ngo HV. Susceptibility to auditory closed-loop stimulation of sleep slow oscillations changes with age. Sleep. 2020.

van Someren EJW, Oosterman JM, Van Harten B, Vogels RL, Gouw AA, Weinstein HC, Poggesi A, Scheltens P, Scherder EJA. Medial temporal lobe atrophy relates more strongly to sleep-wake rhythm fragmentation than to age or any other known risk. Neurobiol Learn Mem. 2019.

Snijders T, Trommelen J, Kouw IWK, Holwerda AM, Verdijk LB, van Loon LJC. The Impact of pre-sleep protein ingestion on the skeletal muscle adaptive response to exercise in humans: an update. Front Nutr. 2019.

Wassenaar TM, Yaffe K, van der Werf YD, Sexton CE. Associations between modifiable risk factors and white matter of the aging brain: insights from diffusion tensor imaging studies. Neurobiol Aging. 2019.

Artificial intelligence in research of sleep and sleep disorder One of the challenges in the research of sleep and sleep disorders is how to get a detailed insight in sleep, without disturbing the behavior itself. We still rely for an important part on EEG based sleep recordings, with associated physiological measurements, codified in polysomnography. Both for scientific research and clinical diagnostics, there is a great need for advancements in this area. With technological advances including the incredibly fast rise of artificial intelligence (AI) a wealth of new opportunities arise to study sleep. For one, AI enables to extract an additional wealth of information from polysomnographic recordings. From the improvement of automatic scoring algorithms based on the AASM criteria, to the development of fundamentally new ways to assess sleep. Moreover, reliable long-term recording of sleep in an unobtrusive way is getting closer and closer. These include the use of wearable technology to obtain heart rate variability and actigraphy, based on which ‘surrogate sleep staging’ is becoming more and more accurate. Interestingly, the physiological variables can also be obtained by non-contact means, for example by mattrass sensors or video technology. In addition, these physiological signals also contain information on sleep-related pathologies, for example related to breathing disorders. These are only examples of the fast-growing repertoire of new measurement modalities, and algorithms for analysis and interpretation, which will likely change the field of sleep research significanly in the coming years.

Prof. Sebastiaan Overeem, MD – Center for Sleep Medicine Kempenhaeghe & Eindhoven University of Technology (TU/e)

SLEEP DIAGNOSTICS & TECHNOLOGY Alvarez-Estevez D, Fernández-Varela I. Large-scale validation of an automatic EEG arousal detection algorithm using different heterogeneous databases. Sleep Med. 2019.

Alvarez-Estevez D, Fernández-Varela I. Addressing database variability in learning from medical data: An ensemble-based approach using convolutional neural networks and a case of study applied to automatic sleep scoring. Comput Biol Med. 2020.

Awais M, Long X, Yin B, Chen C, Akbarzadeh S, Abbasi SF, Irfan M, Lu C, Wang X, Wang L, Chen W. Can pre-trained convolutional neural networks be directly used as a feature extractor for video-based neonatal sleep and wake classification? BMC Res Notes. 2020.

Belur Nagaraj S, Ramaswamy SM, Weerink MAS, Struys MMRF. Predicting deep hypnotic state from sleep brain rhythms using deep learning: a data-repurposing approach. Anesth Analg. 2020.

Borger JN, Huber R, Ghosh A. Capturing sleep-wake cycles by using day-to- day smartphone touchscreen interactions. NPJ Digit Med. 2019. de Mooij SMM, Blanken TF, Grasman RPPP, Ramautar JR, Van Someren EJW, van der Maas HLJ. Dynamics of sleep: Exploring critical transitions and early warning signals. Comput Methods Programs Biomed.

2020.

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Deviaene M, Borzee P, van Gilst M, van Dijk J, Overeem S, Buyse B, Testelmans D, Van Huffel S, Varon C. Multilevel interval coded scoring to assess the cardiovascular status of sleep apnea patients using oxygen saturation markers. IEEE Trans Biomed Eng. 2020. de Vries NM, Smilowska K, Hummelink J, Abramiuc B, van Gilst MM, Bloem BR, de With PHN, Overeem S. Exploring the Parkinson patients’ perspective on home-based video recording for movement analysis: a qualitative study. BMC Neurol. 2019.

Fonseca P, van Gilst MM, Radha M, Ross M, Moreau A, Cerny A, Anderer P, Long X, van Dijk JP, Overeem S. Automatic sleep staging using heart rate variability, body movements, and recurrent neural networks in a sleep disordered population. Sleep. 2020.

Hidding LM, Chinapaw MJM, Belmon LS, Altenburg TM. Co-creating a 24-hour movement behavior tool together with 9-12-year-old children using mixed-methods: MyDailyMoves. Int J Behav Nutr Phys Act. 2020.

Kunkels YK, Knapen SE, Zuidersma M, Wichers M, Riese H, Emerencia AC. ACTman: Automated preprocessing and analysis of actigraphy data. J Sci Med Sport. 2020.

Long X, Otte R, Sanden EV, Werth J, Tan T. Video-Based Actigraphy for Monitoring Wake and Sleep in Healthy Infants: A Laboratory Study.

Sensors (Basel). 2019.

Long X, Espina J, Otte RA, Wang W, Aarts RM, Andriessen P. Videobased actigraphy is an effective contact-free method of assessing sleep in preterm infants. Acta Paediatr. 2020.

MoralesTellez JF, Moeyersons J, Armanac P, Orini M, Faes L, Overeem S, Van Gilst M, Van Dijk J, Huffel SV, Bailon R, Varon C. Model-Based Evaluation of Methods for Respiratory Sinus Arrhythmia Estimation. IEEE Trans Biomed Eng. 2020.

Papini GB, Fonseca P, van Gilst MM, Bergmans JWM, Vullings R, Overeem S. Wearable monitoring of sleep-disordered breathing: estimation of the apnea-hypopnea index using wrist-worn reflective photoplethysmography. Sci Rep. 2020.

Papini GB, Fonseca P, Gilst MMV, Bergmans JW, Vullings R, Overeem S. Respiratory activity extracted from wrist-worn reflective photoplethysmography in a sleep-disordered population. Physiol Meas. 2020.

Papini GB, Fonseca P, van Gilst MM, van Dijk JP, Pevernagie DAA, Bergmans JWM, Vullings R, Overeem S. Estimation of the apnea-hypopnea index in a heterogeneous sleep-disordered population using optimised cardiovascular features. Sci Rep. 2019.

Radha M, Fonseca P, Moreau A, Ross M, Cerny A, Anderer P, Long X, Aarts RM. Sleep stage classification from heart-rate variability using long short-term memory neural networks. Sci Rep. 2019.

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Te Lindert BHW, van der Meijden WP, Wassing R, Lakbila-Kamal O, Wei Y, Van Someren EJW, Ramautar JR. Optimizing actigraphic estimates of polysomnographic sleep features in insomnia disorder. Sleep. 2020. van Kooten JAMC, Terwee CB, Luijten MAJ, Steur LMH, Pillen S, Wolters NGJ, Kaspers GJL, van Litsenburg RRL. Psychometric properties of the Patient-Reported Outcomes Measurement Information System (PROMIS) sleep disturbance and sleep-related impairment item banks in adolescents. J Sleep Res. 2020.

Stevens ML, Gupta N, Inan Eroglu E, Crowley PJ, Eroglu B, Bauman A, Granat M, Straker L, Palm P, Stenholm S, Aadahl M, Mork P, Chastin S, Rangul V, Hamer M, Koster A, Holtermann A, Stamatakis E. Thigh-worn accelerometry for measuring movement and posture across the 24hour cycle: a scoping review and expert statement. BMJ Open Sport Exerc Med. 2020.

Tăuţan AM, Rossi AC, de Francisco R, Ionescu B. Dimensionality reduction for EEG-based sleep stage detection: comparison of autoencoders, principal component analysis and factor analysis. Biomed Tech (Berl). 2020.

Terluin B, van der Wouden JC, de Vet HCW. Measurement equivalence of the Four-Dimensional Symptom Questionnaire (4DSQ) in adolescents and emerging adults. PLoS One. 2019.

Thymi M, Verhoeff MC, Visscher CM, Lobbezoo F. Patient-based experiences with the use of an ambulatory electromyographic device for the assessment of masticatory muscle activity during sleep. J Oral Rehabil. 2020. van Gilst MM, van Dijk JP, Krijn R, Hoondert B, Fonseca P, van Sloun RJG, Arsenali B, Vandenbussche N, Pillen S, Maass H, van den Heuvel L, Haakma R, Leufkens TR, Lauwerijssen C, Bergmans JWM, Pevernagie D, Overeem S. Protocol of the SOMNIA project: an observational study to create a neurophysiological database for advanced clinical sleep monitoring. BMJ Open. 2019. van Gilst MM, Wulterkens BM, Fonseca P, Radha M, Ross M, Moreau A, Cerny A, Anderer P, Long X, van Dijk JP, Overeem S. Direct application of an ECG-based sleep staging algorithm on reflective photoplethysmography data decreases performance. BMC Res Notes. 2020.

Vonk PE, de Vries N, Ravesloot MJL. Polysomnography and sleep position, a Heisenberg phenomenon? : A large-scale series. HNO. 2019.

Werth J, Serteyn A, Andriessen P, Aarts RM, Long X. Automated preterm infant sleep staging using capacitive electrocardiography. Physiol Meas. 2019.

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Insomnia is still keeping us awake Insomnia is common and debilitating across populations. In the last years, Dutch researchers helped to disentangle the potentially underlying mechanisms. In multiple consortia efforts new genetic variants related to insomnia have been discovered, including one of the largest GWAS studies to date in the field. Additionally, brain-related changes and underlying psychological traits have been described to get insight in the predisposing, precipitating and perpetuating factors of insomnia.

Yet, insomnia is not only debilitating in itself, it can also affect our health. Insomnia is considered a risk factor for mental health in particular and has been shown to be a suitable intervention target that alleviates mental health problems. Although this has been consistently demonstrated for years now, it has had a limited effect on clinical practice, also in the Netherlands. CBT for insomnia, the recommended treatment, is still not prescribed or available to a large number of insomnia sufferers. A promising solution could be digital forms of CBT for insomnia, which have demonstrated their efficacy, also in Dutch populations, and require less resource.

Annemarie Luik, PhD - Erasmus MC University Medical Center, Rotterdam

INSOMNIA DISORDER Barclay NL, Kocevska D, Bramer WM, Van Someren EJW, Gehrman P. The heritability of insomnia: A meta-analysis of twin studies. Genes Brain Behav. 2020.

Blanken TF, Van Der Zweerde T, Van Straten A, Van Someren EJW, Borsboom D, Lancee J. Introducing Network Intervention Analysis to Investigate Sequential, Symptom-Specific Treatment Effects: A Demonstration in Co-Occurring Insomnia and Depression. Psychother Psychosom. 2019.

Blanken TF, Benjamins JS, Borsboom D, Vermunt JK, Paquola C, Ramautar J, Dekker K, Stoffers D, Wassing R, Wei Y, Van Someren EJW. Insomnia disorder subtypes derived from life history and traits of affect and personality. Lancet Psychiatry. 2019.

Blanken TF, van Someren EJW. Subtyping insomnia disorder - Authors’ reply. Lancet Psychiatry. 2019.

Bresser T, Foster-Dingley JC, Wassing R, Leerssen J, Ramautar JR, Stoffers D, Lakbila-Kamal O, van den Heuvel M, van Someren EJW. Consistent altered internal capsule white matter microstructure in insomnia disorder. Sleep. 2020.

Christensen JAE, Wassing R, Wei Y, Ramautar JR, Lakbila-Kamal O, Jennum PJ, Van Someren EJW. Data-Driven Analysis of EEG Reveals Concomitant Superficial Sleep During Deep Sleep in Insomnia Disorder.

Front Neurosci. 2019.

Hermans LWA, van Gilst MM, Regis M, van den Heuvel LCE, Langen H, van Mierlo P, Krijn R, Hoondert B, Maass H, van Dijk JP, Leufkens TRM, Overeem S. Modeling sleep onset misperception in insomnia. Sleep.

2020.

Hermans LWA, Leufkens TR, van Gilst MM, Weysen T, Ross M, Anderer P, Overeem S, Vermeeren A. Sleep EEG characteristics associated with sleep onset misperception. Sleep Med. 2019.

Jansen PR, Watanabe K, Stringer S, Skene N, Bryois J, Hammerschlag AR, de Leeuw CA, Benjamins JS, Muñoz-Manchado AB, Nagel M, Savage JE, Tiemeier H, White T; 23andMe Research Team, Tung JY, Hinds DA, Vacic V, Wang X, Sullivan PF, van der Sluis S, Polderman TJC, Smit AB,

Hjerling-Leffler J, Van Someren EJW, Posthuma D. Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways. Nat Genet. 2019.

Jespersen KV, Stevner A, Fernandes H, Sørensen SD, Van Someren E, Kringelbach M, Vuust P. Reduced structural connectivity in Insomnia Disorder. J Sleep Res. 2020.

Leerssen J, Wassing R, Ramautar JR, Stoffers D, Lakbila-Kamal O, Perrier J, Bruijel J, Foster-Dingley JC, Aghajani M, van Someren EJW. Increased hippocampal-prefrontal functional connectivity in insomnia.

Neurobiol Learn Mem. 2019.

Luik AI, Machado PF, Siriwardena N, Espie CA. Screening for insomnia in primary care: using a two-item version of the Sleep Condition Indicator. Br J Gen Pract. 2019.

Nano M, Fonseca P, Overeem S, Vullings R, Aarts RM. Lying awake at night: cardiac autonomic activity in relation to sleep onset and maintenance. Front Neurosci. 2020.

Schiel JE, Holub F, Petri R, Leerssen J, Tamm S, Tahmasian M, Riemann D, Spiegelhalder K. Affect and Arousal in Insomnia: Through a Lens of Neuroimaging Studies. Curr Psychiatry Rep. 2020.

Schinkelshoek MS, de Wit K, Bruggink V, Fronczek R, Lammers GJ. Daytime sleep state misperception in a tertiary sleep centre population.

Sleep Med. 2020.

Te Lindert BHW, Blanken TF, van der Meijden WP, Dekker K, Wassing R, van der Werf YD, Ramautar JR, Van Someren EJW. Actigraphic multinight home-recorded sleep estimates reveal three types of sleep misperception in Insomnia Disorder and good sleepers. J Sleep Res. 2020. van Dalfsen JH, Markus CR. The serotonin transporter 5-HTTLPR polymorphism and the risk for insomnia: a non-replication. Sleep Med. 2019.

Van Someren EJW. Brain mechanisms of insomnia: new perspectives on causes and consequences. Physiol Rev. 2020 Wassing R, Lakbila-Kamal O, Ramautar JR, Stoffers D, Schalkwijk F, Van Someren EJW. Restless REM Sleep Impedes Overnight Amygdala Adaptation. Curr Biol. 2019.

Wassing R, Benjamins JS, Talamini LM, Schalkwijk F, Van Someren EJW. Overnight worsening of emotional distress indicates maladaptive sleep in insomnia. Sleep. 2019. (Erratum in: Sleep. 2019).

Wassing R, Schalkwijk F, Lakbila-Kamal O, Ramautar JR, Stoffers D, Mutsaerts HJMM, Talamini LM, Van Someren EJW. Haunted by the past: old emotions remain salient in insomnia disorder. Brain. 2019.

Wei Y, Leerssen J, Wassing R, Stoffers D, Perrier J, Van Someren EJW. Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder. J Sleep Res. 2020.

Wei Y, Bresser T, Wassing R, Stoffers D, Van Someren EJW, Foster-Dingley JC. Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus. Neuroimage Clin. 2019.

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COGNITIVE BEHAVIOURAL THERAPY FOR INSOMNIA (CBT-I) Baglioni C, Altena E, Bjorvatn B, Blom K, Bothelius K, Devoto A, Espie CA, Frase L, Gavriloff D, Tuuliki H, Hoflehner A, Högl B, Holzinger B, Järnefelt H, Jernelöv S, Johann AF, Lombardo C, Nissen C, Palagini L, Peeters G, Perlis ML, Posner D, Schlarb A, Spiegelhalder K, Wichniak A, Riemann D. The European Academy for Cognitive Behavioural Therapy for Insomnia: An initiative of the European Insomnia Network to promote implementation and dissemination of treatment. J Sleep Res. 2020.

Crawford MR, Luik AI, Espie CA, Taylor HL, Burgess HJ, Jones AL; Rush University Sleep Research Team, Ong JC. Digital Cognitive Behavioral Therapy for Insomnia in Women With Chronic Migraines. Headache.

2020.

Denis D, Eley TC, Rijsdijk F, Zavos HMS, Keers R, Espie CA, Luik AI, Badini I, Derveeuw S, Hodsoll J, Gregory AM. Is digital cognitive behavioural therapy for insomnia effective in treating sub-threshold insomnia: a pilot RCT. Sleep Med. 2020.

Dewald-Kaufmann J, de Bruin E, Michael G. Cognitive Behavioral Therapy for Insomnia (CBT-i) in School-Aged Children and Adolescents.

Sleep Med Clin. 2019.

Ford ME, Geurtsen GJ, Groet E, Van Bennekom CAM, Van Someren EJW. A blended eHealth intervention for insomnia following acquired brain injury: study protocol for a randomized controlled trial. Trials. 2020.

Henry AL, Miller CB, Emsley R, Sheaves B, Freeman D, Luik AI, Littlewood DL, Saunders KEA, Kanady JC, Carl JR, Davis ML, Kyle SD, Espie CA. Insomnia as a mediating therapeutic target for depressive symptoms: A sub-analysis of participant data from two large randomized controlled trials of a digital sleep intervention. J Sleep Res. 2020.

Jespersen KV, Otto M, Kringelbach M, Van Someren E, Vuust P. A randomized controlled trial of bedtime music for insomnia disorder. J Sleep Res. 2019.

Kyle SD, Hurry MED, Emsley R, Marsden A, Omlin X, Juss A, Spiegelhalder K, Bisdounis L, Luik AI, Espie CA, Sexton CE. The effects of digital cognitive behavioral therapy for insomnia on cognitive function: a randomized controlled trial. Sleep. 2020.

Lancee J, Effting M, van der Zweerde T, van Daal L, van Straten A, Kamphuis JH. Cognitive processes mediate the effects of insomnia treatment: evidence from a randomized wait-list controlled trial. Sleep Med. 2019.

Lancee J, Maric M, Kamphuis JH. Sleep restriction therapy may be effective for people with insomnia and depressive complaints: evidence from a case series. Behav Cogn Psychother. 2020.

Leerssen J, Foster-Dingley JC, Lakbila-Kamal O, Dekkers LMS, Albers ACW, Ikelaar SLC, Maksimovic T, Wassing R, Houtman SJ, Bresser T, Blanken TF, Te Lindert B, Ramautar JR, Van Someren EJW. Internetguided cognitive, behavioral and chronobiological interventions in depression-prone insomnia subtypes: protocol of a randomized controlled prevention trial. BMC Psychiatry. 2020 Luik AI, Marsden A, Emsley R, Henry AL, Stott R, Miller CB, Espie CA. Long-term benefits of digital cognitive behavioural therapy for insomnia: Follow-up report from a randomized clinical trial. J Sleep Res. 2020 Luik AI, van der Zweerde T, van Straten A, Lancee J. Digital Delivery of Cognitive Behavioral Therapy for Insomnia. Curr Psychiatry Rep. 2019.

Okujava N, Malashkhia N, Shagidze S, Tsereteli A, Arevadze B, Chikhladze N, de Weerd A, Van Straten A. Digital cognitive behavioral therapy for insomnia - The first Georgian version. Can we use it in practice? Internet Interv. 2019. van der Zweerde T, Lancee J, Luik AI, van Straten A. Internet-Delivered Cognitive Behavioral Therapy for Insomnia: Tailoring Cognitive Behavioral Therapy for Insomnia for Patients with Chronic Insomnia.

Sleep Med Clin. 2020.

Van der Zweerde T, Lancee J, Slottje P, Bosmans JE, Van Someren EJW, van Straten A. Nurse-Guided Internet-Delivered Cognitive Behavioral

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Therapy for Insomnia in General Practice: Results from a Pragmatic Randomized Clinical Trial. Psychother Psychosom. 2020. van der Zweerde T, Bisdounis L, Kyle SD, Lancee J, van Straten A. Cognitive behavioral therapy for insomnia: A meta-analysis of long-term effects in controlled studies. Sleep Med Rev. 2019. van der Zweerde T, van Straten A, Effting M, Kyle SD, Lancee J. Does online insomnia treatment reduce depressive symptoms? A randomized controlled trial in individuals with both insomnia and depressive symptoms. Psychol Med. 2019. van Straten A, Lancee J. Digital cognitive behavioural therapy for insomnia: the answer to a major public health issue? Lancet Digit Health. 2020.

DRUG THERAPY FOR INSOMNIA Brooks S, Jacobs GE, de Boer P, Kent JM, Van Nueten L, van Amerongen G, Zuiker R, Kezic I, Luthringer R, van der Ark P, van Gerven JM, Drevets W. The selective orexin-2 receptor antagonist seltorexant improves sleep: An exploratory double-blind, placebo controlled, crossover study in antidepressant-treated major depressive disorder patients with persistent insomnia. J Psychopharmacol. 2019.

Dujardin S, Pijpers A, Pevernagie D. Prescription drugs used in insomnia. Sleep Med Clin. 2020.

Huiberts LM, Smolders KCHJ. Effects of vitamin D on mood and sleep in the healthy population: Interpretations from the serotonergic pathway. Sleep Med Rev. 2020.

Ivgy-May N, Hajak G, van Osta G, Braat S, Chang Q, Roth T. Efficacy and safety of esmirtazapine in adult outpatients with chronic primary insomnia: a randomized, double-blind placebo-controlled study and open-label extension. J Clin Sleep Med. 2020.

Muehlan C, Brooks S, Zuiker R, van Gerven J, Dingemanse J. Multipledose clinical pharmacology of ACT-541468, a novel dual orexin receptor antagonist, following repeated-dose morning and evening administration. Eur Neuropsychopharmacol. 2019. van Dalfsen JH, Markus CR. The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the sleep-promoting effects of tryptophan: A randomized placebo-controlled crossover study. J Psychopharmacol. 2019.

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Always sleepy: Narcolepsy and central disorders of hypersomnolence (CDH) Narcolepsy and the other CDH’s are rare disorders. However, the complaint of excessive daytime sleepiness is not rare, and may have profound impact on experienced quality of life and the risk for accidents. In most cases it is lifestyle induced.

Understanding the rare neurological causes of excessive daytime sleepiness is relevant, not only for those who suffer from them. Studying these disorders has greatly increased our understanding of sleep(regulation) in general and has, for example, led to the development of a new class of drugs to treat insomnia (dual orexin receptor antagonists).

Dutch researchers play an important role in the international research community focusing on CDH, with narcolepsy as best studied disorder.

Much research is performed by international consortia and particularly in clinical research, Dutch researchers are prominently present.

Actual topics are the improvement of the current classification to allow treatment for all persons with a complaint of hypersomnolence, and also to increase the chance to find reliable biomarkers for hypersomnolence causes other than narcolepsy.

Additional actual topics are the interaction between sleep(disturbance) and metabolism, fMRI studies to better understand the pathophysiology, treatment trials with new innovative pharmacological substances, and the search for the probable auto-immune cause of narcolepsy.

To summarize: there is also plenty of interesting and relevant news to expect the coming years.

Prof. Gert Jan Lammers, MD – Sleep/wake Centre SEIN & Leiden University Medical Centre.

NARCOLEPSY & HYPERSOMNIA Bassetti CLA, Adamantidis A, Burdakov D, Han F, Gay S, Kallweit U, Khatami R, Koning F, Kornum BR, Lammers GJ, Liblau RS, Luppi PH, Mayer G, Pollmächer T, Sakurai T, Sallusto F, Scammell TE, Tafti M, Dauvilliers Y. Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol. 2019 Sep;15(9):519-539.

Dauvilliers Y, Shapiro C, Mayer G, Lammers GJ, Emsellem H, Plazzi G, Chen D, Carter LP, Lee L, Black J, Thorpy MJ. Solriamfetol for the Treatment of Excessive Daytime Sleepiness in Participants with Narcolepsy with and without Cataplexy: Subgroup Analysis of Efficacy and Safety Data by Cataplexy Status in a Randomized Controlled Trial.

CNS Drugs. 2020.

Dietmann A, Horn MP, Schinkelshoek MS, Fronczek R, Salmen A, Bargiotas P, Lammers GJ, Khatami R, Bassetti CLA. Conventional autoantibodies against brain antigens are not routinely detectable in serum and CSF of narcolepsy type 1 and 2 patients. Sleep Med. 2020.

Donjacour CEHM, Lammers GJ, Siegel JM. Striking cessation of cataplexy by opioids. J Sleep Res. 2019.

Emsellem HA, Thorpy MJ, Lammers GJ, Shapiro CM, Mayer G, Plazzi G, Chen D, Carter LP, Villa KF, Lee L, Menno D, Black J, Dauvilliers Y. Measures of functional outcomes, work productivity, and quality of life from a randomized, phase 3 study of solriamfetol in participants with narcolepsy. Sleep Med. 2020.

Fronczek R, Arnulf I, Baumann CR, Maski K, Pizza F, Trotti LM. To split or to lump? Classifying the central disorders of hypersomnolence.

Sleep. 2020.

Gool JK, van der Werf YD, Lammers GJ, Fronczek R. The Sustained Attention to Response Task Shows Lower Cingulo-Opercular and Frontoparietal Activity in People with Narcolepsy Type 1: An fMRI Study on the Neural Regulation of Attention. Brain Sci. 2020.

Gool JK, Fronczek R, Leemans A, Kies DA, Lammers GJ, Van der Werf YD. Widespread white matter connectivity abnormalities in narcolepsy type 1: A diffusion tensor imaging study. Neuroimage Clin. 2019.

Janssens KAM, Quaedackers L, Lammers GJ, Amesz P, van Mierlo P, Aarts L, Peeters E, Hendriks D, Vandenbussche N, Overeem S, Pillen S. Effect of treatment on cognitive and attention problems in children with narcolepsy type 1. Sleep. 2020.

Lammers GJ, Bassetti CLA, Dolenc-Groselj L, Jennum PJ, Kallweit U, Khatami R, Lecendreux M, Manconi M, Mayer G, Partinen M, Plazzi G, Reading PJ, Santamaria J, Sonka K, Dauvilliers Y. Diagnosis of central disorders of hypersomnolence: A reappraisal by European experts. Sleep Med Rev. 2020.

Lammers GJ, Bassetti CLA, Dauvilliers Y. Reply to Micoulaud-Franchi et al. Commentary on diagnosis of central disorders of hypersomnolence: From clinic to clinic via ontology and semantic analysis on a bullet point path. Sleep Med Rev. 2020.

Lammers GJ, Bassetti CLA, Dauvilliers Y. Reply to Maski K et al. commentary on diagnosis of central disorders of hypersomnolence: Challenges in defining central disorders of hypersomnolence. Sleep Med Rev. 2020.

Quaedackers L, van Gilst MM, van Mierlo P, Lammers GJ, Dhondt K, Amesz P, Peeters E, Hendriks D, Vandenbussche N, Pillen S, Overeem S. Impaired social functioning in children with narcolepsy. Sleep. 2019 Feb 1;42(2).

Quaedackers L, De Wit J, Pillen S, Van Gilst M, Batalas N, Lammers GJ, Markopoulos P, Overeem S. A Mobile App for Longterm Monitoring of Narcolepsy Symptoms: Design, Development, and Evaluation. JMIR Mhealth Uhealth. 2020.

Schinkelshoek M, Fronczek R, Verduijn W, Haasnoot G, Overeem S, Donjacour C, van der Heide A, Roelen D, Claas F, Lammers GJ. HLA associations in narcolepsy type 1 persist after the 2009 H1N1 pandemic. J Neuroimmunol. 2020.

Schinkelshoek MS, Fronczek R, Kooy-Winkelaar EMC, Petersen J, Reid HH, van der Heide A, Drijfhout JW, Rossjohn J, Lammers GJ, Koning F. H1N1 hemagglutinin- specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls. J Neuroimmunol. 2019.

Schinkelshoek MS, Smolders IM, Donjacour CE, van der Meijden WP, van Zwet EW, Fronczek R, Lammers GJ. Decreased body mass index during treatment with sodium oxybate in narcolepsy type 1. J Sleep Res. 2019.

Schinkelshoek MS, Lammers GJ, Fronczek R. The development of hypocretin deficiency in narcolepsy type 1 can be swift and closely linked to symptom onset: clues from a singular case. Sleep. 2019.

Straat ME, Schinkelshoek MS, Fronczek R, Lammers GJ, Rensen PCN, Boon MR. Role of Brown Adipose Tissue in Adiposity Associated With Narcolepsy Type 1. Front Endocrinol (Lausanne). 2020. van Holst RJ, Janssen LK, van Mierlo P, Lammers GJ, Cools R, Overeem S, Aarts E. Publisher Correction: Enhanced food-related responses in the ventral medial prefrontal cortex in narcolepsy type 1. Sci Rep. 2019. (Erratum for: Sci Rep. 2018).

Zhang Z, Gool J, Fronczek R, Dauvilliers Y, Bassetti CLA, Mayer G, Plazzi G, Pizza F, Santamaria J, Partinen M, Overeem S, Peraita-Adrados R, da Silva AM, Sonka K, Del Rio-Villegas R, Heinzer R, Wierzbicka A, Young P, Högl B, Manconi M, Feketeova E, Mathis J, Paiva T, Canellas F, Lecendreux M, Baumann CR, Lammers GJ, Khatami R. New 2013 incidence peak in childhood narcolepsy: more than vaccination? Sleep. 2020.

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Sleep apnea research in the Netherlands Last years an increased activity has been observed from different research groups and hospitals in the Netherlands in the area of sleepdisordered breathing, particularly in obstructive sleep apnea. Overall, 75 papers were identified, including 15 contributions in the area of dental sleep medicine and mandibular advancement therapy. Focus is mainly on treatment monitoring, patient selection and prediction of outcome, including studies on telemedicine, CPAP adherence, maxillomandibular advancement therapy, obesity, atrial fibrillation, bariatric surgery, upper airway surgery, hypoglossal nerve stimulation, and maxillo-mandibular osteotomy. Finally, also a number of clinical observations and case series have been reported. Different groups found access to international cohorts and multicenter studies, and published different meta-analyses (4), which is promising and hopeful for the future.

Prof. Johan Verbraecken, MD - University of Antwerp, Belgium.

SLEEP APNEA Aardoom JJ, Loheide-Niesmann L, Ossebaard HC, Riper H. Effectiveness of eHealth Interventions in Improving Treatment Adherence for Adults With Obstructive Sleep Apnea: Meta-Analytic Review. J Med Internet Res. 2020.

Aalaei S, Rezaeitalab F, Tabesh H, Amini M, Afsharisaleh L, Mostafavi SM, Asadpour H, Eslami S. Factors Affecting Patients’ Adherence to Continuous Positive Airway Pressure Therapy for Obstructive Sleep Apnea Disorder: A Multi- Method Approach. Iran J Med Sci. 2020 Aarab G, Arcache P, Lavigne GJ, Lobbezoo F, Huynh N. The effects of mandibular advancement appliance therapy on jaw-closing muscle activity during sleep in patients with obstructive sleep apnea: a 3-6 months follow-up. J Clin Sleep Med. 2020.

Abma IL, Rovers MM, IJff M, Hol B, Nägele M, Westert GP, van der Wees PJ. Does the Patient-Reported Apnea Questionnaire (PRAQ) increase patient- centredness in the daily practice of sleep centres? a mixedmethods study. BMJ Open. 2019.

Almendros I, El-Merhie N, Jha A, Keir HR, Lykouras D, Mahmutovic Persson I, Ubags ND, Bartel S. Early Career Members at the Lung Science Conference and the Sleep and Breathing Conference 2019. Breathe (Sheff). 2019.

Arellano-Maric MP, Hamm C, Duiverman ML, Schwarz S, Callegari J, Storre JH, Schmoor C, Spielmanns M, Galetke W, Windisch W. Obesity hypoventilation syndrome treated with non-invasive ventilation: Is a switch to CPAP therapy feasible? Respirology. 2020.

Benoist LBL, Vonk PE, de Vries N, Janssen HCJP, Verbraecken J. Newgeneration positional therapy in patients with positional central sleep apnea. Eur Arch Otorhinolaryngol. 2019.

Blackshaw H, Springford LR, Zhang LY, Wang B, Venekamp RP, Schilder AG. Tonsillectomy versus tonsillotomy for obstructive sleep-disordered breathing in children. Cochrane Database Syst Rev. 2020.

Chen A, Burger MS, Rietdijk-Smulders MAWJ, Smeenk FWJM. Mandibular advancement device: Effectiveness and dental side effects. A real-life study. Cranio. 2020.

Chen H, Eckert DJ, van der Stelt PF, Guo J, Ge S, Emami E, Almeida FR, Huynh NT. Phenotypes of responders to mandibular advancement device therapy in obstructive sleep apnea patients: A systematic review and meta-analysis. Sleep Med Rev. 2020.

Chen H, Aarab G, Lobbezoo F, De Lange J, Van der Stelt P, Darendeliler MA, Cistulli PA, Sutherland K, Dalci O. Differences in three-dimensional craniofacial anatomy between responders and non-responders to mandibular advancement splint treatment in obstructive sleep apnoea patients. Eur J Orthod. 2019.

De Meyer MMD, Vanderveken OM, De Weerdt S, Marks LAM, Cárcamo BA, Chavez AM, Matamoros FA, Jacquet W. Use of mandibular advancement devices for the treatment of primary snoring with or without obstructive sleep apnea (OSA): A systematic review. Sleep Med Rev. 2020. de Ruiter MHT, Apperloo RC, Milstein DMJ, de Lange J. Facial esthetics and subjective impairment assessed after maxillomandibular advancement surgery for patients with obstructive sleep apnea. Cranio.

2020.

de Ruiter MHT, Aarab G, de Vries N, Lobbezoo F, de Lange J. A stepwise titration protocol for oral appliance therapy in positional obstructive sleep apnea patients: proof of concept. Sleep Breath. 2020. de Vries GE, Hoekema A, Vermeulen KM, Claessen JQPJ, Jacobs W, van der Maten J, van der Hoeven JH, Stegenga B, Kerstjens HAM, Wijkstra PJ. Clinical- and Cost-Effectiveness of a Mandibular Advancement Device Versus Continuous Positive Airway Pressure in Moderate Obstructive Sleep Apnea. J Clin Sleep Med. 2019. de Vries GE, Hoekema A, Claessen JQPJ, Stellingsma C, Stegenga B, Kerstjens HAM, Wijkstra PJ. Long-Term Objective Adherence to Mandibular Advancement Device Therapy Versus Continuous Positive Airway Pressure in Patients With Moderate Obstructive Sleep Apnea. J Clin Sleep Med. 2019. den Ottelander B, Gaillard L, Yang S, de Goederen R, Bredero-Boelhouwer H, van Veelen ML, Tasker R, Joosten K, Mathijssen I. Adult SaethreChotzen Syndrome: A Unique Abnormal Breathing Pattern. J Craniofac Surg. 2020 Dec 21 Desteghe L, Linz D, Hendriks JM. Sleep Apnea Testing and Management in Patients With Atrial Fibrillation: Why is it So Difficult? J Cardiovasc Nurs. 2020.

Dieleman E, Veugen CCAFM, Hardeman JA, Copper MP. Drug-induced sleep endoscopy while administering CPAP therapy in patients with CPAP failure. Sleep Breath. 2020.

Donze SH, de Weerd AW, van den Bossche RAS, Joosten KFM, HokkenKoelega ACS. Sleep-related breathing disorders in young adults with Prader-Willi syndrome: a placebo-controlled, cross-over GH trial. J Clin Endocrinol Metab. 2019.

Eerdekens R, Bouwmeester S. Atrial septal defect and haemodynamic consequences of continuous positive airway pressure treatment.

Lancet. 2020.

Fabius TM, Benistant JR, Bekkedam L, van der Palen J, de Jongh FHC, Eijsvogel MMM. Validation of the oxygen desaturation index in the diagnostic workup of obstructive sleep apnea. Sleep Breath. 2019.

Fabius TM, Benistant JR, Pleijhuis RG, van der Palen J, Eijsvogel MMM. The use of oximetry and a questionnaire in primary care enables exclusion of a subsequent obstructive sleep apnea diagnosis. Sleep Breath. 2020.

Garde A, Hoppenbrouwer X, Dehkordi P, Zhou G, Rollinson AU, Wensley D, Dumont GA, Ansermino JM. Pediatric pulse oximetry-based OSA screening at different thresholds of the apnea-hypopnea index with an expression of uncertainty for inconclusive classifications. Sleep Med. 2019.

Hendriks JM, Linz D. Screening for obstructive sleep apnoea in patients with atrial fibrillation: Much more than a screening tool alone.

Int J Cardiol Heart Vasc. 2020.

Houppermans P, Verweij J, Gooris P, Asin J, Bergsma E, van Merkesteyn R, Mensink G. Maxillomandibular advancement in edentulous patients as a treatment option for obstructive sleep apnea: report of two cases and a proposed treatment protocol. Heliyon. 2020.

Janssen HCJP, Venekamp LN, Peeters GAM, Pijpers A, Pevernagie DAA. Management of insomnia in sleep disordered breathing. Eur Respir Rev. 2019.

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Kadhim K, Lau DH, Sanders P, Linz D. Sleep apnea in atrial fibrillation Highly prevalent, highly relevant, but most patients are not somnolent! Int J Cardiol Heart Vasc. 2020.

Linz D, Homberg M, van der Velden RMJ, Bouman E, Buhre W, Simons SO. Sleep apnea, obesity and COPD depress respiration during catheter ablation procedures: Implications for transcutaneous carbon dioxide monitoring. Int J Cardiol. 2020.

Linz D, Loffler KA, Sanders P, Catcheside P, Anderson CS, Zheng D, Quan W, Barnes M, Redline S, McEvoy RD, Baumert M; SAVE (Sleep Apnea Cardiovascular Endpoints) Investigators. Low Prognostic Value of Novel Nocturnal Metrics in Patients With OSA and High Cardiovascular Event Risk: Post Hoc Analyses of the SAVE Study. Chest. 2020.

Linz B, Hohl M, Lang L, Wong DWL, Nickel AG, De La Torre C, Sticht C, Wirth K, Boor P, Maack C, Speer T, Jespersen T, Schotten U, Sanders P, Böhm M, Linz D. Repeated exposure to transient obstructive sleep apnea-related conditions causes an atrial fibrillation substrate in a chronic rat model. Heart Rhythm. 2020.

Linz D, Hendriks J. Central sleep apnea in atrial fibrillation: Risk factor or marker of untreated underlying disease? Int J Cardiol Heart Vasc. 2020.

Linz D, Dobrev D. Sleep apnea and atrial fibrillation: Update 2020. Int J Cardiol Heart Vasc. 2020.

Linz D, Linz B, Heijman J. Sleep Apnea, Intermittent Hypoxemia, and Effects on Ischemic Myocardial Damage: Friend or Foe? Can J Cardiol. 2020.

Linz D, Baumert M, Desteghe L, Kadhim K, Vernooy K, Kalman JM, Dobrev D, Arzt M, Sastry M, Crijns HJGM, Schotten U, Cowie MR, McEvoy RD, Heidbuchel H, Hendriks J, Sanders P, Lau DH. Nightly sleep apnea severity in patients with atrial fibrillation: Potential applications of long-term sleep apnea monitoring. Int J Cardiol Heart Vasc. 2019.

Lisan Q, van Sloten T, Climie RE, Boutouyrie P, Guibout C, Thomas F, Danchin N, Jouven X, Empana JP. Sleep apnoea is associated with hearing impairment: The Paris prospective study 3. Clin Otolaryngol.

2020.

Lisan Q, Van Sloten T, Marques Vidal P, Haba Rubio J, Heinzer R, Empana JP. Association of Positive Airway Pressure Prescription With Mortality in Patients With Obesity and Severe Obstructive Sleep Apnea: The Sleep Heart Health Study. JAMA Otolaryngol Head Neck Surg. 2019.

Maas BDPJ, Bruintjes TD, van der Zaag-Loonen HJ, van Leeuwen RB. The relation between dizziness and suspected obstructive sleep apnoea. Eur Arch Otorhinolaryngol. 2020.

Nikolopoulou M, Aarab G, Ahlberg J, Hamburger HL, de Lange J, Lobbezoo F. Oral appliance therapy versus nasal continuous positive airway pressure in obstructive sleep apnea: A randomized, placebo-controlled trial ontemporomandibular side-effects. Clin Exp Dent Res. 2020.

Oppersma E, Ganglberger W, Sun H, Thomas RJ, Westover MB. Algorithm for automatic detection of self-similarity and prediction of residual central respiratory events during CPAP. Sleep. 2020.

Peker Y, Thunström E, Glantz H, Eulenburg C. Effect of Obstructive Sleep Apnea and CPAP Treatment on Cardiovascular Outcomes in Acute Coronary Syndrome in the RICCADSA Trial. J Clin Med. 2020.

Pottel L, Neyt N, Hertegonne K, Pevernagie D, Veys B, Abeloos J, De Clercq C. Long-term quality of life outcomes of maxillomandibular advancement osteotomy in patients with obstructive sleep apnoea syndrome. Int J Oral Maxillofac Surg. 2019.

Ravesloot MJL, de Raaff CAL, van de Beek MJ, Benoist LBL, Beyers J, Corso RM, Edenharter G, den Haan C, Heydari Azad J, Ho JTF, Hofauer B, Kezirian EJ, van Maanen JP, Maes S, Mulier JP, Randerath W, Vanderveken OM, Verbraecken J, Vonk PE, Weaver EM, de Vries N. Perioperative Care of Patients With Obstructive Sleep Apnea Undergoing Upper Airway Surgery: A Review and Consensus Recommendations.

JAMA Otolaryngol Head Neck Surg. 2019. (Erratum in: JAMA Otolaryngol Head Neck Surg. 2019).

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Reijers SNH, Nijland LMG, Bosschieter PFN, de Raaff CAL, Ravesloot MJL, van Veen RN, de Castro SMM, de Vries N. The effect of postoperative CPAP use on anastomotic and staple line leakage after bariatric surgery. Sleep Breath. 2020.

Surda P, Putala M, Siarnik P, Walker A, De Rome K, Amin N, Sangha MS, Fokkens W. Sleep in elite swimmers: prevalence of sleepiness, obstructive sleep apnoea and poor sleep quality. BMJ Open Sport Exerc Med. 2019.

Talib A, Roebroek YGM, van Waardenburg DA, van der Grinten CPM, Winkens B, Bouvy ND, van Heurn ELWE. Obstructive sleep apnea in obese adolescents referred for bariatric surgery: association with metabolic and cardiovascular variables. Sleep Med. 2020.

Timkova V, Nagyova I, Reijneveld SA, Tkacova R, van Dijk JP, Bültmann U. Psychological distress in patients with obstructive sleep apnoea: The role of hostility and coping self-efficacy. J Health Psychol. 2020.

Timkova V, Nagyova I, Reijneveld SA, Tkacova R, van Dijk JP, Bültmann U. Are disease severity, sleep-related problems, and anxiety associated with work functioning in patients with obstructive sleep apnoea? Disabil Rehabil. 2019.

Timkova V, Nagyova I, Reijneveld SA, Tkacova R, Stewart RE, van Dijk JP, Bültmann U. Suicidal ideation in patients with obstructive sleep apnoea and its relationship with disease severity, sleep-related problems and social support. J Health Psychol. 2020.

Timkova V, Nagyova I, Reijneveld SA, Tkacova R, van Dijk JP, U. Quality of life of obstructive sleep apnoea patients receiving continuous positive airway pressure treatment: A systematic review and metaanalysis. Heart Lung. 2020.

Treskes RW, Maan AC, Verwey HF, Schot R, Beeres SLMA, Tops LF, Van Der Velde ET, Schalij MJ, Slats AM. Mobile Health for Central Sleep Apnea Screening Among Patients With Stable Heart Failure: SingleCohort, Open, Prospective Trial. JMIR Cardio. 2019.

Uniken Venema JAM, Doff MHJ, Joffe-Sokolova DS, Wijkstra PJ, van der Hoeven JH, Stegenga B, Hoekema A. Dental side effects of long-term obstructive sleep apnea therapy: a 10-year follow-up study. Clin Oral Investig. 2020.

Uniken Venema JAM, Doff MHJ, Joffe-Sokolova D, Wijkstra PJ, van der Hoeven JH, Stegenga B, Hoekema A. Long-term obstructive sleep apnea therapy: a 10-year follow-up of mandibular advancement device and continuous positive airway pressure. J Clin Sleep Med. 2020. van den Broek N, Broer L, Vandenbussche N, Tan I, Overeem S, Pillen S. Obstructive sleep apnea in people with intellectual disabilities: adherence to and effect of CPAP. Sleep Breath. 2020.

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van der Weijden FN, Lobbezoo F, Slot DE. The effect of playing a wind instrument or singing on risk of sleep apnea: a systematic review and meta- analysis. J Clin Sleep Med. 2020.

Vonk PE, Ravesloot MJL, Kasius KM, van Maanen JP, de Vries N. Floppy epiglottis during drug-induced sleep endoscopy: an almost complete resolution by adopting the lateral posture. Sleep Breath. 2020.

van Durme C, Spaetgens B, Driessen J, Nielen J, Sastry M, Boonen A, de Vries F. Obstructive sleep apnea and the risk of gout: a populationbased case-control study. Arthritis Res Ther. 2020.

Vonk PE, Rotteveel PJ, Ravesloot MJL, Ho JTF, de Lange J, de Vries N. The influence of position dependency on surgical success in patients with obstructive sleep apnea undergoing maxillomandibular advancement. J Clin Sleep Med. 2020.

van Loenhout L, van der Zeijden H. An Unusual Cause of CPAP Intolerance. J Clin Sleep Med. 2019. van Veldhuisen SL, Hazebroek EJ. Obstructive Sleep Apnea in Adults.

N Engl J Med. 2019. van Veldhuisen SL, Arslan I, Deden LN, Aarts EO, Hazebroek EJ. Safety of Continuous Postoperative Pulse Oximetry Monitoring Without Obstructive Sleep Apnea Screening in > 5000 Patients Undergoing Bariatric Surgery. Obes Surg. 2020. van Veldhuisen SL, Kuppens K, de Raaff CAL, Wiezer MJ, de Castro SMM, van Veen RN, Swank DJ, Demirkiran A, Boerma EG, Greve JM, van Dielen FMH, Frederix GWJ, Hazebroek EJ. Protocol of a multicentre, prospective cohort study that evaluates cost-effectiveness of two perioperative care strategies for potential obstructive sleep apnoea in morbidly obese patients undergoing bariatric surgery. BMJ Open. 2020.

Veugen CCAFM, Teunissen EM, den Otter LAS, Kos MP, Stokroos RJ, Copper MP. Prediction of obstructive sleep apnea: comparative performance of three screening instruments on the apnea-hypopnea index and the oxygen desaturation index. Sleep Breath. 2020.

Vonk PE, Uniken Venema JAM, Hoekema A, Ravesloot MJL, van de Velde-Muusers JA, de Vries N. Jaw thrust versus the use of a boil-andbite mandibular advancement device as a screening tool during drug-induced sleep endoscopy. J Clin Sleep Med. 2020.

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Vonk PE, Ravesloot MJL, van Maanen JP, de Vries N. Short-term results of upper airway stimulation in obstructive sleep apnoea patients: the Amsterdam experience. J Laryngol Otol. 2020.

Vonk PE, Rotteveel PJ, Ravesloot MJL, den Haan C, de Vries N. The influence of position-dependency on surgical success in sleep apnea surgery - a systematic review. Sleep Breath. 2020.

Vrooman OPJ, van Balken MR, van Koeveringe GA, van Kerrebroeck PVA, Driessen LEMJ, Schouten LJ, Rahnama’i MS. The effect of continuous positive airway pressure on nocturia in patients with obstructive sleep apnea syndrome. Neurourol Urodyn. 2020.

Vuorjoki-Ranta TR, Aarab G, Lobbezoo F, Tuomilehto H, Ahlberg J. Weight gain may affect mandibular advancement device therapy in patients with obstructive sleep apnea: a retrospective study. Sleep Breath. 2019.

Wolters TLC, Roerink SHPP, Drenthen LCA, van Haren-Willems JHGM, Wagenmakers MAEM, Smit JWA, Hermus ARMM, Netea-Maier RT. The Course of Obstructive Sleep Apnea Syndrome in Patients With Acromegaly During Treatment. J Clin Endocrinol Metab. 2020.

Zhou N, Ho JTF, De Vries N, De Lange J. Obstructive sleep apnea caused by acromegaly: Case report. Cranio. 2020.

Broadening the horizon of Dental Sleep Medicine The first thing that comes to mind when you think of the dentist is probably not sleep. However, the dentist can play an important role in the recognition, prevention, and management of sleep disorders. It is thus with good reason that Dental Sleep Medicine has recently developed as a new offshoot of dentistry. Traditionally, the discipline mainly dealt with the dental aspects of obstructive sleep apnea, notably its management with mandibular advancement devices. More recently, focus is expanding to include sleep-related bruxism, orofacial pain, gastroesophageal reflux, dry mouth, and drooling. The scientific output of Dental Sleep Medicine is rapidly growing, with the number of publications increasing from 50 in 1999 to >300 in 2020 (Web of Science). Researchers of the Academic Centre for Dentistry Amsterdam (ACTA) are very active in furthering this intriguing and clinically highly relevant domain.

Also in the Dutch dental curriculum, where sleep was not amongst the competencies of future dentists, new developments are underway.

Recently, the following competency was included in the undergraduate curriculum nationwide: "… treats obstructive sleep apnea syndrome or refers the patient for it." In line with the above-indicated expansion of Dental Sleep Medicine, similar competencies will now be formulated for the other “dental” sleep disorders. All this illustrates the broadening horizon of Dental Sleep Medicine.

Frank Lobbezoo, DDS, PhD & Ghizlane Aarab, DDS, PhD - Dpt of Orofacial Pain and Dysfunction - ACTA - University of Amsterdam and Vrije Universiteit Amsterdam

DENTAL SLEEP MEDICINE Ahlberg J, Piirtola M, Lobbezoo F, Manfredini D, Korhonen T, Aarab G, Hublin C, Kaprio J. Correlates and genetics of self-reported sleep and awake bruxism in a nationwide twin cohort. J Oral Rehabil. 2020.

Baad-Hansen L, Thymi M, Lobbezoo F, Svensson P. To what extent is bruxism associated with musculoskeletal signs and symptoms? A systematic review. J Oral Rehabil. 2019. de Baat C, Verhoeff M, Ahlberg J, Manfredini D, Winocur E, Zweers P, Rozema F, Vissink A, Lobbezoo F. Medications and addictive substances potentially inducing or attenuating sleep bruxism and/or awake bruxism. J Oral Rehabil. 2020.

Gouw S, Frowein A, Braem C, de Wijer A, Creugers NHJ, Pasman JW, Doorduin J, Kalaykova SI. Coherence of jaw and neck muscle activity during sleep bruxism. J Oral Rehabil. 2020.

Lobbezoo F, Lavigne GJ, Kato T, de Almeida FR, Aarab G. The face of Dental Sleep Medicine in the 21st century. J Oral Rehabil. 2020.

Lobbezoo F, de Vries N, de Lange J, Aarab G. A Further Introduction to Dental Sleep Medicine. Nat Sci Sleep. 2020.

Lobbezoo F, Aarab G, Ahlers MO, Baad-Hansen L, Bernhardt O, Castrillon EE, Giannakopoulos NN, Grønbeck A, Hauschild J, Holst-Knudsen M, Skovlund N, Thymi M, Svensson P. Consensus-based clinical guidelines for ambulatory electromyography and contingent electrical stimulation in sleep bruxism. J Oral Rehabil. 2020.

Lobbezoo F, Aarab G. Dental sleep medicine in the dental curriculum: what should be the dot on the horizon? Sleep Breath. 2020 Jun 24.

Lobbezoo F, Li J, Koutris M, Warnsinck CJ, Wetselaar P, Visscher CM, Aarab G. Nasal CPAP therapy associated with masticatory muscle myalgia. J Clin Sleep Med. 2020.

Manfredini D, Ahlberg J, Wetselaar P, Svensson P, Lobbezoo F. The bruxism construct: From cut-off points to a continuum spectrum. J Oral Rehabil. 2019.

Manfredini D, Ahlberg J, Aarab G, Bracci A, Durham J, Ettlin D, Gallo LM, Koutris M, Wetselaar P, Svensson P, Lobbezoo F. Towards a Standardized Tool for the Assessment of Bruxism (STAB)-Overview and general remarks of a multidimensional bruxism evaluation system. J Oral Rehabil. 2020.

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Muzalev K, Visscher CM, Koutris M, Lobbezoo F. Effect of experimental temporomandibular disorder pain on sleep bruxism: a pilot study in males. Clin Oral Investig. 2020.

Thymi M, Shimada A, Lobbezoo F, Svensson P. Clinical jaw-muscle symptoms in a group of probable sleep bruxers. J Dent. 2019.

Thymi M, Visscher CM, Wismeijer D, Lobbezoo F. Associations between sleep bruxism and (peri-)implant complications: lessons learned from a clinical study. BDJ Open. 2020.

PARASOMNIAS & MOVEMENT DISORDERS

van Selms M, Kroon J, Tuomilehto H, Peltomaa M, Savolainen A, Manfredini D, Lobbezoo F, Ahlberg J. Self-reported sleep bruxism among Finnish symphony orchestra musicians: Associations with perceived sleep-related problems and psychological stress. Cranio. 2020.

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van Selms MKA, Marpaung C, Pogosian A, Lobbezoo F. Geographical variation of parental-reported sleep bruxism among children: comparison between the Netherlands, Armenia and Indonesia. Int Dent J. 2019.

Wetselaar P, Vermaire EJH, Lobbezoo F, Schuller AA. The prevalence of awake bruxism and sleep bruxism in the Dutch adult population. J Oral Rehabil. 2019.

Wetselaar P, Manfredini D, Ahlberg J, Johansson A, Aarab G, Papagianni CE, Reyes Sevilla M, Koutris M, Lobbezoo F. Associations between tooth wear and dental sleep disorders: A narrative overview. J Oral Rehabil. 2019.

REM parasomnias: a call for action REM parasomnias are relatively prevalent and have serious consequences. It is also of interest because disturbed REM sleep seems related to impaired emotional processing and (the formation) of psychopathology. One way to learn about this relationship is to study dreaming. Dreaming may not be limited to REM sleep but is a prominent feature. Lucid dreaming may be used as a window to understand the relationship (e.g. Baird et al., 2019; Gott et al, 2020). Yet another way is to study the treatment of separate parasomnias. In this vein it is promising that imagery rehearsal was found to be effective for posttraumatic nightmares (Yücel et al., 2020). However, more action is needed. Regularizing REM sleep may be one of the gateways to a better (mental) health. Therefore we desperately need studies that further study REM and REM parasomnia. In line with Gieselmann et al. (2019) it is of eminent importance that these studies are carried out in clinical groups.

Jaap Lancee, PhD – University of Amsterdam, Amsterdam

REM SLEEP BEHAVIOUR DISORDER (RBD) Arnaldi D, Meles SK, Giuliani A, Morbelli S, Renken RJ, Janzen A, Mayer G, Jonsson C, Oertel WH, Nobili F, Leenders KL, Pagani M; REMPET Study Group. Brain Glucose Metabolism Heterogeneity in Idiopathic REM Sleep Behavior Disorder and in Parkinson’s Disease. J Parkinsons Dis. 2019.

Dommershuijsen LJ, Darweesh SKL, Luik AI, Kieboom BCT, Koudstaal PJ, Boon AJW, Ikram MA, Ikram MK, Bunnik EM. Ethical Considerations in Screening for Rapid Eye Movement Sleep Behavior Disorder in the General Population. Mov Disord. 2020.

Kamps S, van den Heuvel OA, van der Werf YD, Berendse HW, Weintraub D, Vriend C. Smaller subcortical volume in Parkinson patients with rapid eye movement sleep behavior disorder.

Brain Imaging Behav. 2019.

Kogan RV, Janzen A, Meles SK, Sittig E, Renken RJ, Gurvits V, Mayer G, Leenders KL, Oertel WH; REMPET Working Group. Four-Year Follow-up of 18F-Fluorodeoxyglucose Positron Emission Tomography-Based Parkinson’s Disease-Related Pattern Expression in 20 Patients With Isolated Rapid Eye Movement Sleep Behavior Disorder Shows Prodromal Progression. Mov Disord. 2020.

DREAMING Baird B, Mota-Rolim SA, Dresler M. The cognitive neuroscience of lucid dreaming. Neurosci Biobehav Rev. 2019.

Blake Y, Terburg D, Balchin R, van Honk J, Solms M. The role of the basolateral amygdala in dreaming. Cortex. 2019.

Gott J, Rak M, Bovy L, Peters E, van Hooijdonk CFM, Mangiaruga A, Varatheeswaran R, Chaabou M, Gorman L, Wilson S, Weber F, Talamini L, Steiger A, Dresler M. Sleep fragmentation and lucid dreaming. Conscious Cogn. 2020. van Heugten-van der Kloet D, Lynn SJ. Dreams and Dissociation-Commonalities as a Basis for Future Research and Clinical Innovations.

Front Psychol. 2020.

NIGHTMARE DISORDER Gieselmann A, Ait Aoudia M, Carr M, Germain A, Gorzka R, Holzinger B, Kleim B, Krakow B, Kunze AE, Lancee J, Nadorff MR, Nielsen T, Riemann D, Sandahl H, Schlarb AA, Schmid C, Schredl M, Spoormaker VI, Steil R, van Schagen AM, Wittmann L, Zschoche M, Pietrowsky R. Aetiology and treatment of nightmare disorder: State of the art and future perspectives. J Sleep Res. 2019.

Lancee J, Effting M, Kunze AE. Telephone-guided imagery rehearsal therapy for nightmares: Efficacy and mediator of change. J Sleep Res. 2020.

Lancee J, Yücel DE, Souama C, van Emmerik AAP. Reply to Zhang et al.: Downgrading recommendation level of prazosin for treating trauma-related nightmares: Should decision be based on a single study? Sleep Med Rev. 2020.

Yücel DE, van Emmerik AAP, Souama C, Lancee J. Comparative efficacy of imagery rehearsal therapy and prazosin in the treatment of trauma-related nightmares in adults: A metaanalysis of randomized controlled trials. Sleep Med Rev. 2020.

LIMB MOVEMENT DISORDERS Anguelova GV, Vlak MHM, Kurvers AGY, Rijsman RM. Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome. Sleep Med Clin. 2020.

Hallegraeff J, de Greef M. Pilot testing a stretching regimen for prevention of night time nocturnal leg cramps. Geriatr Nurs. 2020.

Schipper MH, Alvarez-Estevez D, Jellema K, Verbraecken J, Fulda S, Rijsman RM. Sleep-related leg movements in obstructive sleep apnea: definitions, determinants, and clinical consequences. Sleep Med. 2020.

Tobback E, Desmet O, Hanoulle I, Delesie L, Pevernagie D, Vogelaers D, Mariman A. Retrospective Analysis of Risk Factors for Periodic Limb Movements in a Large Cohort of Insomnia and Chronic Fatigue Patients. Pharmacopsychiatry. 2020.

S L E E P & P H YS I C A L H E A LT H

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CARDIOVASCULAR AND METABOLIC DISEASE Bishehsari F, Voigt RM, Keshavarzian A. Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer. Nat Rev Endocrinol. 2020.

Bos MM, van Heemst D, Donga E, de Mutsert R, Rosendaal FR, Blauw GJ, Rensen PCN, Biermasz NR, Noordam R. The association between habitual sleep duration and sleep quality with glycemic traits: assessment by cross-sectional and Mendelian randomization analyses.

J Clin Med. 2019.

Bos MM, Noordam R, van den Berg R, de Mutsert R, Rosendaal FR, Blauw GJ, Rensen PCN, Biermasz NR, van Heemst D. Associations of sleep duration and quality with serum and hepatic lipids: The Netherlands Epidemiology of Obesity Study. J Sleep Res. 2019.

Brouwer A, van Raalte DH, Nguyen HT, Rutters F, van de Ven PM, Elders PJM, Moll AC, Van Someren EJW, Snoek FJ, Beekman ATF, Bremmer MA. Effects of Light Therapy on Mood and Insulin Sensitivity in Patients With Type 2 Diabetes and Depression: Results From a Randomized Placebo-Controlled Trial. Diabetes Care. 2019.

Brouwer A, Asare Bediako I, Paszkiewicz RL, Kolka CM, Bergman RN, Broussard JL. Impact of sleep deprivation and high-fat feeding on insulin sensitivity and beta cell function in dogs. Diabetologia. 2020.

Brouwer A, van Raalte DH, Rutters F, Elders PJM, Snoek FJ, Beekman ATF, Bremmer MA. Sleep and HbA1c in Patients With Type 2 Diabetes: Which Sleep Characteristics Matter Most? Diabetes Care. 2020.

Buurma M, van Diemen JJK, Thijs A, Numans ME, Bonten TN. Circadian Rhythm of Cardiovascular Disease: The Potential of Chronotherapy With Aspirin. Front Cardiovasc Med. 2019.

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Muilwijk M, Stenvers DJ, Nicolaou M, Kalsbeek A, van Valkengoed IGM. Behavioral Circadian Timing System Disruptors and Incident Type 2 Diabetes in a Nonshift Working Multiethnic Population. Obesity (Silver Spring). 2020.

Nefs GM, Bazelmans E, Donga E, Tack CJ, de Galan BE. Sweet dreams or bitter nightmare: a narrative review of 25 years of research on the role of sleep in diabetes and the contributions of behavioural science. Diabet Med. 2020.

Siland JE, Zwartkruis V, Geelhoed B, de Boer RA, van Gelder IC, van der Harst P, Rienstra M. Lifestyle components: Self-reported physical activity, nutritional status, sleep quality and incident atrial fibrillation.

Int J Cardiol Heart Vasc. 2020.

Stenvers DJ, Scheer FAJL, Schrauwen P, la Fleur SE, Kalsbeek A. Circadian clocks and insulin resistance. Nat Rev Endocrinol. 2019. van Dijk D, Balkau B, Segrestin B, Gottsäter M, Gabriel R, Hatunic M, Mari A, Dekker JM, Rutters F; EGIR-RISC Study Group. Associations between sleep duration and sleep debt with insulin sensitivity and insulin secretion in the EGIR-RISC Study. Diabetes Metab. 2019. van Buuren M, Hinnen C. Are Morbid Obesity and Insomnia Related?

Investigating associated factors in a clinical setting. J Clin Psychol Med Settings. 2020. van Kamp I, Simon S, Notley H, Baliatsas C, van Kempen E. Evidence relating to environmental noise exposure and annoyance, sleep disturbance, cardiovascular and metabolic health outcomes in the context of IGCB (N): a scoping review of new evidence. Int J Environ Res Public Health. 2020.

CANCER

Crnko S, Du Pré BC, Sluijter JPG, Van Laake LW. Circadian rhythms and the molecular clock in cardiovascular biology and disease. Nat Rev Cardiol. 2019.

Flanagan EW, Most J, Broskey NT, Altazan AD, Beyl RA, Keadle SK, Drews KL, Singh P, Redman LM. Identification of changes in sleep across pregnancy and the impact on cardiometabolic health and energy intake in women with obesity. Sleep Med. 2020.

Hausler N, Lisan Q, Van Sloten T, Haba-Rubio J, Perier MC, Thomas F, Danchin N, Guibout C, Boutouyrie P, Heinzer R, Jouven X, Marques-Vidal P, Empana JP. Cardiovascular health and sleep disturbances in two population-based cohort studies. Heart. 2019.

Bernard P, Savard J, Steindorf K, Sweegers MG, Courneya KS, Newton RU, Aaronson NK, Jacobsen PB, May AM, Galvao DA, Chinapaw MJ, Stuiver MM, Griffith KA, Mesters I, Knoop H, Goedendorp MM, Bohus M, Thorsen L, Schmidt ME, Ulrich CM, Sonke GS, van Harten W, WintersStone KM, Velthuis MJ, Taaffe DR, van Mechelen W, Kersten MJ, Nollet F, Wenzel J, Wiskemann J, Verdonck-de Leeuw IM, Brug J, Buffart LM. Effects and moderators of exercise on sleep in adults with cancer: Individual patient data and aggregated meta-analyses. J Psychosom Res. 2019.

Hofmeijer J, van Kaam R, Vermeer SE, van Putten MJAM. Severely Disturbed Sleep in Patients With Acute Ischemic Stroke on Stroke Units: A Pilot Study. Front Neurol. 2019.

Daniel LC, van Litsenburg RRL, Rogers VE, Zhou ES, Ellis SJ, Wakefield CE, Stremler R, Walter L, Crabtree VM; International Psycho-Oncology Society Pediatrics Special Interest Group. A call to action for expanded sleep research in pediatric oncology: A position paper on behalf of the International Psycho- Oncology Society Pediatrics Special Interest Group. Psychooncology. 2020.

Koolhaas CM, Kocevska D, Te Lindert BHW, Erler NS, Franco OH, Luik AI, Tiemeier H. Objectively measured sleep and body mass index: a prospective bidirectional study in middle-aged and older adults.

Sleep Med. 2019.

Kilgallen AB, Štibler U, Printezi MI, Putker M, Punt CJA, Sluijter JPG, May AM, van Laake LW. Comparing Conventional Chemotherapy to Chronomodulated Chemotherapy for Cancer Treatment: Protocol for a Systematic Review. JMIR Res Protoc. 2020.

Koopman ADM, Beulens JW, Dijkstra T, Pouwer F, Bremmer MA, van Straten A, Rutters F. Prevalence of Insomnia (Symptoms) in T2D and Association With Metabolic Parameters and Glycemic Control: Meta-Analysis. J Clin Endocrinol Metab. 2020.

Rensen N, Steur LMH, Schepers SA, Merks JHM, Moll AC, Grootenhuis MA, Kaspers GJL, van Litsenburg RRL. Concurrence of sleep problems and distress: prevalence and determinants in parents of children with cancer. Eur J Psychotraumatol. 2019.

NSWO DUTCH YEAR IN REVIEW 2019/2020

Santoso AMM, Jansen F, de Vries R, Leemans CR, van Straten A, Verdonck-de Leeuw IM. Prevalence of sleep disturbances among head and neck cancer patients: A systematic review and meta-analysis.

Sleep Med Rev. 2019.

Steur LMH, Grootenhuis MA, Van Someren EJW, Van Eijkelenburg NKA, Van der Sluis IM, Dors N, Van den Bos C, Tissing WJE, Kaspers GJL, Van Litsenburg RRL. High prevalence of parent-reported sleep problems in pediatric patients with acute lymphoblastic leukemia after induction therapy. Pediatr Blood Cancer. 2020.

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M, Chaudhuri KR. Non-motor correlates of wrist-worn wearable sensor use in Parkinson’s disease: an exploratory analysis. NPJ Parkinsons Dis. 2019.

Verhoeff MC, Koutris M, van Selms MKA, Brandwijk AN, Heres MS, Berendse HW, van Dijk KD, Lobbezoo F. Is dopaminergic medication dose associated with self-reported bruxism in Parkinson’s disease? A cross-sectional, questionnaire-based study. Clin Oral Investig. 2020 Sep 12.

ALZHEIMER & DEMENTIA

Steur LMH, Kaspers GJL, van Someren EJW, van Eijkelenburg NKA, van der Sluis IM, Dors N, van den Bos C, Tissing WJE, Grootenhuis MA, van Litsenburg RRL. The impact of maintenance therapy on sleep-wake rhythms and cancer-related fatigue in pediatric acute lymphoblastic leukemia. Support Care Cancer. 2020.

Steur LMH, Kaspers GJL, Van Someren EJW, Van Eijkelenburg NKA, Van der Sluis IM, Dors N, Van den Bos C, Tissing WJE, Grootenhuis MA, Van Litsenburg RRL. Sleep-wake rhythm disruption is associated with cancer-related fatigue in pediatric acute lymphoblastic leukemia.

Sleep. 2020. van Kooten JAMC, Maurice-Stam H, Schouten AYN, van Vuurden DG, Granzen B, Gidding C, de Ruiter MA, van Litsenburg RRL, Grootenhuis MA. High occurrence of sleep problems in survivors of a childhood brain tumor with neurocognitive complaints: The association with psychosocial and behavioral executive functioning. Pediatr Blood Cancer. 2019. van Schaik J, Pillen S, van Litsenburg RRL, Vandenbussche NLE, de Bont JM, Schouten-van Meeteren AYN, van Santen HM. The importance of specialized sleep investigations in children with a suprasellar tumor. Pituitary. 2020.

Havekes R, Heckman PRA, Wams EJ, Stasiukonyte N, Meerlo P, Eisel ULM. Alzheimer’s disease pathogenesis: The role of disturbed sleep in attenuated brain plasticity and neurodegenerative processes. Cell Signal. 2019.

Lysen TS, Ikram MA, Ghanbari M, Luik AI. Sleep, 24-h activity rhythms, and plasma markers of neurodegenerative disease. Sci Rep. 2020.

Lysen TS, Luik AI, Ikram MK, Tiemeier H, Ikram MA. Actigraphy-estimated sleep and 24-hour activity rhythms and the risk of dementia.

Alzheimers Dement. 2020.

Ngo HV, Claassen J, Dresler M. Sleep: Slow Wave Activity Predicts Amyloid- Accumulation. Curr Biol. 2020.

Prins AJ, Scherder EJA, van Straten A, Zwaagstra Y, Milders MV. Sensory Stimulation for Nursing-Home Residents: Systematic Review and Meta-Analysis of Its Effects on Sleep Quality and Rest-Activity Rhythm in Dementia. Dement Geriatr Cogn Disord. 2020.

Reddy OC, van der Werf YD. The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices. Brain Sci. 2020.

PARKINSON DISEASE Fifel K, Videnovic A. Chronotherapies for Parkinson’s disease. Prog Neurobiol. 2019.

Lysen TS, Darweesh SKL, Ikram MK, Luik AI, Ikram MA. Sleep and risk of parkinsonism and Parkinson’s disease: a population-based study.

Brain. 2019.

Roos DS, Twisk JWR, Raijmakers PGHM, Doty RL, Berendse HW. Hyposmia as a marker of (non-)motor disease severity in Parkinson’s disease. J Neural Transm (Vienna). 2019.

Rutten S, Vriend C, Smit JH, Berendse HW, van Someren EJW, Hoogendoorn AW, Twisk JWR, van der Werf YD, van den Heuvel OA. Bright light therapy for depression in Parkinson disease: A randomized controlled trial. Neurology. 2019.

Thomas J, Ooms SJ, Mentink LJ, Booij J, Olde Rikkert MGM, Overeem S, Kessels RPC, Claassen JAHR. Effects of long-term sleep disruption on cognitive function and brain amyloid- burden: a case-control study.

Alzheimers Res Ther. 2020.

Thomas J, Overeem S, Claassen JAHR. Long-Term Occupational Sleep Loss and Post-Retirement Cognitive Decline or Dementia. Dement Geriatr Cogn Disord. 2019.

Thomas J, Ooms S, Verbeek M, Booij J, Rijpkema M, Kessels RPC, Overeem S, Claassen J. Sleep-Cognition Hypothesis In maritime Pilots, what is the effect of long-term work-related poor sleep on cognition and amyloid accumulation in healthy middle-aged maritime pilots: methodology of a case-control study. BMJ Open. 2019.

Van Erum J, Van Dam D, De Deyn PP. Alzheimer’s disease: Neurotransmitters of the sleep-wake cycle. Neurosci Biobehav Rev. 2019.

Smilowska K, van Wamelen DJ, Schoutens AMC, Meinders MJ, Bloem BR. Blue Light Therapy Glasses in Parkinson’s Disease: Patients’ Experience. Parkinsons Dis. 2019.

EPILEPSY

van Wamelen DJ, Hota S, Podlewska A, Leta V, Trivedi D, Rizos A, Parry

Gutter T, Callenbach PMC, Brouwer OF, de Weerd AW. Prevalence of sleep disturbances in people with epilepsy and the impact on quality of life: a survey in secondary care. Seizure. 2019.

Jansen FE, Nikanorova M, Peltola M. Current treatment options for Encephalopathy related to Status Epilepticus during slow Sleep. Epileptic Disord. 2019.

Moffet EW, Verhagen R, Jones B, Findlay G, Juan E, Bugnon T, Mensen A, Aparicio MK, Maganti R, Struck AF, Tononi G, Boly M. Local Sleep Slow-Wave Activity Colocalizes With the Ictal Symptomatogenic Zone in a Patient With Reflex Epilepsy: A High-Density EEG Study. Front Syst Neurosci. 2020.

Nobili L, de Weerd A, Rubboli G, Beniczky S, Derry C, Eriksson S, Halasz P, Högl B, Santamaria J, Khatami R, Ryvlin P, Rémi J, Tinuper P, Bassetti C, Manni R, Koutroumanidis M, Vignatelli L. Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: A European Academy of Neurology, European Sleep Research Society and International League against Epilepsy-Europe consensus review. J Sleep Res. 2020.

Smyk MK, van Luijtelaar G. Circadian Rhythms and Epilepsy: A Suitable Case for Absence Epilepsy. Front Neurol. 2020.

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Smyk MK, Sysoev IV, Sysoeva MV, van Luijtelaar G, Drinkenburg WH. Can absence seizures be predicted by vigilance states?: Advanced analysis of sleep- wake states and spike-wave discharges’ occurrence in rats. Epilepsy Behav. 2019.

Borren NZ, Tan W, Colizzo FP, Luther J, Garber JJ, Khalili H, van Der Woude CJ, Ananthakrishnan AN. Longitudinal Trajectory of Fatigue With Initiation of Biologic Therapy in Inflammatory Bowel Diseases: A Prospective Cohort Study. J Crohns Colitis. 2020.

van den Munckhof B, Gefferie SR, van Noort SAM, van Teeseling HC, Schijvens MP, Smit W, Teunissen NW, Plate JDJ, Huiskamp GJM, Leijten FSS, Braun KPJ, Jansen FE, Bölsterli BK. Sleep slow-wave homeostasis and cognitive functioning in children with electrical status epilepticus in sleep. Sleep. 2020.

de Goederen R, Cuperus IE, Tasker RC, den Ottelander BK, Dremmen MHG, van Veelen MC, Spoor JKH, Joosten KFM, Mathijssen IMJ. Dural sinus volume in children with syndromic craniosynostosis and intracranial hypertension. J Neurosurg Pediatr. 2020.

BRAIN INJURY Arnts H, van Erp WS, Boon LI, Bosman CA, Admiraal MM, Schrantee A, Pennartz CMA, Schuurman R, Stam CJ, van Rootselaar AF, Hillebrand A, van den Munckhof P. Awakening after a sleeping pill: Restoring functional brain networks after severe brain injury. Cortex. 2020.

Bruijel J, Vermeeren A, van der Sluiszen NNJJM, Jongen S, Stapert SZ, van Heugten CM. Measuring fatigue following acquired brain injury: A validation study of the Psychomotor Vigilance Test. J Rehabil Med. 2020.

Catsman-Berrevoets C. Physical activity after mild traumatic brain injury: What are the relationships with fatigue and sleep quality? Is physical activity a key to prevention of post-concussive symptoms?

Eur J Paediatr Neurol. 2019.

Fleming MK, Smejka T, Henderson Slater D, van Gils V, Garratt E, Yilmaz Kara E, Johansen-Berg H. Sleep Disruption After Brain Injury Is Associated With Worse Motor Outcomes and Slower Functional Recovery.

Neurorehabil Neural Repair. 2020.

de Goederen R, Joosten KFM, den Ottelander BK, van der Oest MJW, Bröker- Schenk EMM, van Veelen MC, Wolvius EB, Versnel SL, Tasker RC, Mathijssen IMJ. Improvement in Sleep Architecture is associated with the Indication of Surgery in Syndromic Craniosynostosis. Plast Reconstr Surg Glob Open. 2019. de Rooij A, van der Leeden M, Roorda LD, Rinkema M, Beuving W, Dekker J. Factors Associated With Sleep Quality in Patients With Chronic Widespread Pain Attending Multidisciplinary Treatment. Pain Pract.

2020.

Estévez-López F, Maestre-Cascales C, Russell D, Álvarez-Gallardo IC, Rodriguez-Ayllon M, Hughes CM, Davison GW, Sañudo B, McVeigh JG. Effectiveness of Exercise on Fatigue and Sleep Quality in Fibromyalgia: A Systematic Review and Meta-analysis of Randomized Trials.

Arch Phys Med Rehabil. 2020.

Hulst RY, Voorman JM, Pillen S, Ketelaar M, Visser-Meily JMA, Verschuren O. Parental perspectives on care for sleep in children with cerebral palsy: a wake- up call. Disabil Rehabil. 2020.

Kamdar BB, Simons KS, Spronk PE. Can ICUs create more sleep by creating less noise? Intensive Care Med. 2020.

Ford ME, Groet E, Daams JG, Geurtsen GJ, Van Bennekom CAM, Van Someren EJW. Non-pharmacological treatment for insomnia following acquired brain injury: A systematic review. Sleep Med Rev. 2020.

Lancel M, Stroebe M, Eisma MC. Sleep disturbances in bereavement: A systematic review. Sleep Med Rev. 2020 Oct;53:101331.

Luik AI, Iyadurai L, Gebhardt I, Holmes EA. Sleep disturbance and intrusive memories after presenting to the emergency department following a traumatic motor vehicle accident: an exploratory analysis.

Eur J Psychotraumatol. 2019.

Lange PW, Clayton-Chubb DI, Watson R, Maier AB. Results from a double blinded, randomized, placebo-controlled, feasibility trial of melatonin for the treatment of delirium in older medical inpatients. Intern Med J. 2020.

Spanò G, Weber FD, Pizzamiglio G, McCormick C, Miller TD, Rosenthal CR, Edgin JO, Maguire EA. Sleeping with Hippocampal Damage. Curr Biol. 2020.

McPhee PG, Verschuren O, Peterson MD, Tang A, Gorter JW. The Formula for Health and Well-Being in Individuals With Cerebral Palsy: Cross-Sectional Data on Physical Activity, Sleep, and Nutrition. Ann Rehabil Med. 2020.

van Markus-Doornbosch F, Peeters E, van der Pas S, Vlieland TV, Meesters J. Physical activity after mild traumatic brain injury: What are the relationships with fatigue and sleep quality? Eur J Paediatr Neurol.

2019. van Markus-Doornbosch F, Peeters E, Volker G, van der Pas S, Vliet Vlieland T, Meesters J. Physical activity, fatigue and sleep quality at least 6 months after mild traumatic brain injury in adolescents and young adults: A comparison with orthopedic injury controls. Eur J Paediatr Neurol. 2019.

COVID-19 Erren TC, Lewis P, Shaw DM. COVID-19 and “natural” experiments arising from physical distancing: a hypothetical case study from chronobiology. Chronobiol Int. 2020.

Kocevska D, Blanken TF, Van Someren EJW, Rösler L. Sleep quality during the COVID-19 pandemic: not one size fits all. Sleep Med. 2020.

Quaedackers L, Overeem S, Pillen S. Two sides of a coin: differential response to COVID-19 distancing measures in children with narcolepsy. J Clin Sleep Med. 2020.

OTHER Balk YA, de Jonge J, Oerlemans WG, Geurts SA. Physical recovery, mental detachment and sleep as predictors of injury and mental energy. J Health Psychol. 2019.

Borges-Cosic M, Aparicio VA, Estévez-López F, Soriano-Maldonado A, Acosta- Manzano P, Gavilán-Carrera B, Delgado-Fernández M, Geenen R, Segura-Jiménez V. Sedentary time, physical activity, and sleep quality in fibromyalgia: The al- Ándalus project. Scand J Med Sci Sports. 2019.

Moyers SA, Tiemensma J. The association between physical activity, sleep, and quality of life in patients in bio-chemical remission from Cushing’s syndrome. Qual Life Res. 2020.

Nauts S, Kamphorst BA, Stut W, De Ridder DTD, Anderson JH. The Explanations People Give for Going to Bed Late: A Qualitative Study of the Varieties of Bedtime Procrastination. Behav Sleep Med. 2019.

Reinke L, Haveman M, Horsten S, Falck T, van der Heide EM, Pastoor S, van der Hoeven JH, Absalom AR, Tulleken JE. The importance of the intensive care unit environment in sleep - A study with healthy participants. J Sleep Res. 2020.

Rood P, Frenzel T, Verhage R, Bonn M, van der Hoeven H, Pickkers P, van den Boogaard M. Development and daily use of a numeric rating score to assess sleep quality in ICU patients. J Crit Care. 2019.

Schieveld JNM, Strik JJMH. Melatonin and Sleep Dysregulation at the PICU. Pediatr Crit Care Med. 2020.

Smit DJM, Zwinkels M, Takken T, Hulst RY, de Groot JF, Lankhorst K, Verschuren O. Sleep quantity and its relation with physical activity in children with cerebral palsy; insights using actigraphy. J Paediatr Child Health. 2020.

Vermeiren MR, Kranenburg LW, van Daele PLA, Gerth van Wijk R, Hermans MAW. Psychological functioning and quality of life in patients with mastocytosis: A cross-sectional study. Ann Allergy Asthma Immunol. 2020.

S L E E P & M E N TA L H E A LT H

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Sleep and mental health: towards an integrative view on etiology and treatment Previously solely regarded as a symptom of psychiatric disorders, sleep disorders have now taken central stage in research on the development, progression and remission of psychiatric disorders. This is reflected by the considerable amount of publications on this subject by NSWO members. Research subjects cover both etiological and treatment perspectives of sleep in relation to a wide range of mental health problems and disorders. Sleep and mental health are repeatedly found to be so closely intertwined that some leading researchers on this topic suggest some psychiatric disorders should actually be regarded as sleep disorders, and vice versa. This view implies an important paradigm shift from predominantly causal inference to shared genetic or developmental confounding effects, and influences both research and clinical practice.

Although much work is still left to be done, the growing body of knowledge on the association between sleep and mental health is being translated to both preventative and clinical care, through close collaborations between neuroscientists, clinical researchers and practitioners. Special attention is still warranted to integrate this knowledge within educational and training programs for researchers as well as primary and mental health care professionals.

Maaike van Veen, psychiatrist / epidemiologist, Center of Expertise on Sleep & Psychiatry GGZ Drenthe, Assen Jeanine Kamphuis, psychiatrist, PhD, University Center of Psychiatry, Groningen

MOOD & ANXIETY Bagherzadeh-Azbari S, Khazaie H, Zarei M, Spiegelhalder K, Walter M, Leerssen J, Van Someren EJW, Sepehry AA, Tahmasian M. Neuroimaging insights into the link between depression and Insomnia: A systematic review. J Affect Disord. 2019.

Bais B, Lindeboom R, van Ravesteyn L, Tulen J, Hoogendijk W, Lambregtse-van den Berg M, Kamperman A. The Impact of Objective and Subjective Sleep Parameters on Depressive Symptoms during Pregnancy in Women with a Mental Disorder: An Explorative Study. Int J Environ Res Public Health. 2019.

Blanken TF, Borsboom D, Penninx BW, Van Someren EJ. Network outcome analysis identifies difficulty initiating sleep as a primary target for prevention of depression: a 6-year prospective study. Sleep.

2020.

Difrancesco S, Lamers F, Riese H, Merikangas KR, Beekman ATF, van Hemert AM, Schoevers RA, Penninx BWJH. Sleep, circadian rhythm, and physical activity patterns in depressive and anxiety disorders: A 2-week ambulatory assessment study. Depress Anxiety. 2019.

Dolsen MR, Prather AA, Lamers F, Penninx BWJH. Suicidal ideation and suicide attempts: associations with sleep duration, insomnia, and inflammation. Psychol Med. 2020.

Druiven SJM, Knapen SE, Penninx BWJH, Antypa N, Schoevers RA, Riese H, Meesters Y. Can chronotype function as predictor of a persistent course of depressive and anxiety disorder? J Affect Disord.

2019.

Druiven SJM, Hovenkamp-Hermelink JHM, Knapen SE, Kamphuis J, Haarman BCM, Penninx BWJH, Antypa N, Meesters Y, Schoevers RA, Riese H. Stability of chronotype over a 7-year follow-up period and its association with severity of depressive and anxiety symptoms. Depress Anxiety. 2020.

Gottlieb JF, Benedetti F, Geoffroy PA, Henriksen TEG, Lam RW, Murray G, Phelps J, Sit D, Swartz HA, Crowe M, Etain B, Frank E, Goel N, Haarman BCM, Inder M, Kallestad H, Jae Kim S, Martiny K, Meesters Y, Porter R, Riemersma-van der Lek RF, Ritter PS, Schulte PFJ, Scott J, Wu JC, Yu X, Chen S. The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology. Bipolar Disord. 2019.

Knapen SE, Li P, Riemersma-van der Lek RF, Verkooijen S, Boks MPM, Schoevers RA, Scheer FAJL, Hu K. Fractal biomarker of activity in patients with bipolar disorder. Psychol Med. 2020.

Leerssen J, Blanken TF, Pozzi E > …….. < Thompson PM, Schmaal L, Van Someren EJW. Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group. Transl Psychiatry. 2020.

Morssinkhof MWL, van Wylick DW, Priester-Vink S, van der Werf YD, den Heijer M, van den Heuvel OA, Broekman BFP. Associations between sex hormones, sleep problems and depression: A systematic review.

Neurosci Biobehav Rev. 2020.

Narmandakh A, Roest AM, Jonge P, Oldehinkel AJ. The bidirectional association between sleep problems and anxiety symptoms in adolescents: a TRAILS report. Sleep Med. 2020.

Recourt K, de Boer P, Zuiker R, Luthringer R, Kent J, van der Ark P, Van Hove I, van Gerven J, Jacobs G, van Nueten L, Drevets W. The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder. Transl Psychiatry. 2019. (Erratum in: Transl Psychiatry. 2019).

Sikkens D, Riemersma-Van der Lek RF, Meesters Y, Schoevers RA, Haarman BCM. Combined sleep deprivation and light therapy: Clinical treatment outcomes in patients with complex unipolar and bipolar depression. J Affect Disord. 2019.

Ten Thij M, Bathina K, Rutter LA, Lorenzo-Luaces L, van de Leemput IA, Scheffer M, Bollen J. Depression alters the circadian pattern of online activity. Sci Rep. 2020. van Dalfsen JH, Markus CR. The involvement of sleep in the relationship between the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and depression: A systematic review. J Affect Disord. 2019.

ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD) & AUTISM SPECTRUM DISORDER (ASD) Arns M, Vollebregt MA. Editorial: Time to Wake Up: Appreciating the Role of Sleep in Attention-Deficit/Hyperactivity Disorder. J Am Acad Child Adolesc Psychiatry. 2019.

Bijlenga D, Vollebregt MA, Kooij JJS, Arns M. The role of the circadian system in the etiology and pathophysiology of ADHD: time to redefine ADHD? Atten Defic Hyperact Disord. 2019.

Deserno MK, Borsboom D, Begeer S, Agelink van Rentergem JA, Mataw K, Geurts HM. Sleep determines quality of life in autistic adults: A longitudinal study. Autism Res. 2019.

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Hohn VD, de Veld DMJ, Mataw KJS, van Someren EJW, Begeer S. Insomnia Severity in Adults with Autism Spectrum Disorder is Associated with sensory Hyper-Reactivity and Social Skill Impairment. J Autism Dev Disord. 2019.

Dimitrova L, Fernando V, Vissia EM, Nijenhuis ERS, Draijer N, Reinders AATS. Sleep, trauma, fantasy and cognition in dissociative identity disorder, post-traumatic stress disorder and healthy controls: a replication and extension study. Eur J Psychotraumatol. 2020.

Korman M, Palm D, Uzoni A, Faltraco F, Tucha O, Thome J, Coogan AN. ADHD 24/7: Circadian clock genes, chronotherapy and sleep/wake cycle insufficiencies in ADHD. World J Biol Psychiatry. 2020.

Krediet E, Janssen DG, Heerdink ER, Egberts TC, Vermetten E. Experiences with medical cannabis in the treatment of veterans with PTSD: Results from a focus group discussion. Eur Neuropsychopharmacol.

2020.

Levelink B, van der Vlegel M, Mommers M, Gubbels J, Dompeling E, Feron FJM, van Zeben-van der Aa DMCB, Hurks P, Thijs C. The Longitudinal Relationship Between Screen Time, Sleep and a Diagnosis of AttentionDeficit/Hyperactivity Disorder in Childhood. J Atten Disord. 2020.

Solleveld MM, Schrantee A, Baek HK, Bottelier MA, Tamminga HGH, Bouziane C, Stoffelsen R, Lucassen PJ, Van Someren EJW, Rijsman RM, Reneman L. Effects of 16 Weeks of Methylphenidate Treatment on Actigraph-Assessed Sleep Measures in Medication-Naive Children With ADHD. Front Psychiatry. 2020. van Andel E, Bijlenga D, Vogel SWN, Beekman ATF, Kooij JJS. Effects of chronotherapy on circadian rhythm and ADHD symptoms in adults with attention- deficit/hyperactivity disorder and delayed sleep phase syndrome: a randomized clinical trial. Chronobiol Int. 2020. van Andel E, Ten Have M, Bijlenga D, Beekman ATF, de Graaf R, Sandra Kooij JJ. Combined impact of ADHD and insomnia symptoms on quality of life, productivity, and health care use in the general population.

Psychol Med. 2020.

Meentken MG, van der Mheen M, van Beynum IM, Aendekerk EWC, Legerstee JS, van der Ende J, Del Canho R, Lindauer RJL, Hillegers MHJ, Moll HA, Helbing WA, Utens EMWJ. EMDR for children with medically related subthreshold PTSD: short- term effects on PTSD, blood-injection-injury phobia, depression and sleep. Eur J Psychotraumatol. 2020.

Repantis D, Wermuth K, Tsamitros N, Danker-Hopfe H, Bublitz JC, Kühn S, Dresler M. REM sleep in acutely traumatized individuals and interventions for the secondary prevention of post-traumatic stress disorder. Eur J Psychotraumatol. 2020.

SUBSTANCE USE Devenney LE, Coyle KB, Roth T, Verster JC. Sleep after Heavy Alcohol Consumption and Physical Activity Levels during Alcohol Hangover. J Clin Med. 2019.

Panagiotou M, Meijer M, Meijer JH, Deboer T. Effects of chronic caffeine consumption on sleep and the sleep electroencephalogram in mice. J Psychopharmacol. 2019.

Vollebregt MA, Kenemans JL, Buitelaar JK, Deboer T, Cain SW, Palmer D, Elliott GR, Gordon E, Fallahpour K, Arns M. Annual variation in attentional response after methylphenidate treatment. Eur Child Adolesc Psychiatry. 2020.

Pasman JA, Smit DJA, Kingma L, Vink JM, Treur JL, Verweij KJH. Causal relationships between substance use and insomnia. Drug Alcohol Depend. 2020. Erratum in: Drug Alcohol Depend. 2020.

Zwennes CTC, Loth CA. “Moments of Failure”: Coping With Attention Deficit Hyperactivity Disorder, Sleep Deprivation, and Being Overweight: A Qualitative Hermeneutic-Phenomenological Investigation Into Participant Perspectives. J Addict Nurs. 2019.

Winiger EA, Ellingson JM, Morrison CL, Corley RP, Pasman JA, Wall TL, Hopfer CJ, Hewitt JK. Sleep Deficits and Cannabis Use Behaviors: An Analysis of Shared Genetics Using Linkage Disequilibrium Score Regression and Polygenic Risk Prediction. Sleep. 2020.

POST TRAUMATIC STRESS DISORDER (PTSD)

OTHER

Agorastos A, Olff M. Traumatic stress and the circadian system: neurobiology, timing and treatment of posttraumatic chronodisruption.

Eur J Psychotraumatol. 2020.

Koopman-Verhoeff ME, Bolhuis K, Cecil CAM, Kocevska D, Hudziak JJ, Hillegers MHJ, Mileva-Seitz VR, Reiss IK, Duijts L, Verhulst F, Luijk MPCM, Tiemeier H. During day and night: Childhood psychotic experiences and objective and subjective sleep problems. Schizophr Res. 2019.

de Boer M, Nijdam MJ, Jongedijk RA, Bangel KA, Olff M, Hofman WF, Talamini LM. The spectral fingerprint of sleep problems in post-traumatic stress disorder. Sleep. 2020.

Milic J, Saavedra Perez H, Zuurbier LA, Boelen PA, Rietjens JA, Hofman A, Tiemeier H. The Longitudinal and Cross-Sectional Associations of Grief and Complicated Grief With Sleep Quality in Older Adults.

Behav Sleep Med. 2019.

Sahbaz C, Özer OF, Kurtulmus A, Kırpınar I, Sahin F, Guloksuz S. Evidence for an association of serum melatonin concentrations with recognition and circadian preferences in patients with schizophrenia. Metab Brain Dis. 2019. ter Heege FM, Mijnster T, van Veen MM, Pijnenborg GHM, de Jong PJ, Boersma GJ, Lancel M. The clinical relevance of early identification and treatment of sleep disorders in mental health care: protocol of a randomized control trial. BMC Psychiatry. 2020.

Van Veen MM, Karsten J, Verkes RJ, Lancel M. Sleep quality is associated with aggression in forensic psychiatric patients, independent of general psychopathology. The Journal of Forensic Psychiatry & Psychology 2020. van Veen MM, Rutters F, Spreen M, Lancel M. Poor sleep quality at baseline is associated with increased aggression over one year in forensic psychiatric patients. Sleep Med. 2020.

NSWO DUTCH YEAR IN REVIEW 2019/2020

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BOOKLIST

Slaapstoornissen in de psychiatrie: diagnose en behandeling Onder redactie van Lancel M, van Veen MM, Kamphuis J. Bohn Stafleu van Loghum.

2020.

Sleep Medicine for Dentists: An Evidence-Based Overview Lavigne GJ, Cistulli PA, Smith MT (eds). 2nd ed. Batavia, IL: Quintessence Publishing Co, Inc, 2020.

Slaaptraining voor jongeren op basis van CGT en motiverende gespreksvoering

Mijn Slaap Plan & Werkboek BoekKuin07-1120199789036823319

Leerboek Neurowetenschappen voor de klinische psychiatrie van den Heuvel O, van der Werf Y, Schmand B, Sabbe B (eds). Boom, deTijdstroom.

2020.

Slapen is niets doen Kruit A. Uitgeverij Lucht. 2019.

Goede nacht Leijten I & Kruit A. Uitgeverij Thema. 2020.

Slaap, het nieuwe medicijn Verbraecken J & Bergen T. Uitgeverij Houtekiet. 2020.

Dear Good morning Lienke de Jong. Uitgever Lev. 2020.

Sleep & Sleep Disorders A Practical Handbook Verbraecken J, Buyse B, Hamburger H, Kasteel V van, Steenwijk R van (eds). Leuven, Den Haag: Acco, 2019

Woezel en Pip – Slaap lekker Guusje Nederhorst Dromenjager Publishing BV. 2020.