Journal of Research in Unani Medicine, Vol 4, Issue 1
Standard manufacturing procedure of Qurse Tabasheer - A herbo mineral Unani anti diabetic formulation Waris Ali, *Hamiduddin,AkhtarAli
Dept. of Ilmul Saidla (Unani pharmacy), National Institute of Unani Medicine (NIUM), Bangalore-91, Karnataka, India
*CorrespondingAuthor Email: drhamid2003@rediffmail.com Abstract
Background and Objectives: Qurs (Tablet) is one of the most suitable dosage forms due to its easy portability,
stability and accuracy of dose etc. Unani tablets contain diverse crude drugs which require specific manufacturing procedures for good quality of finished products to be maintained. In this work Qurse Tabasheer containing six ingredients, Tabasheer (Siliceous concretions) , Gule Surkh (Rosa damascena Mill. flower), Gulnar (Punica granatum Linn. flower), Tukhme kahu (Lactuca sativa Linn. seeds), Tukhme khurfa (Portulaca oleraceae Linn.
seeds ) and Gile Armani was taken up for study due to its important indication in diabetes, hummae hadda and diarrhea . Objective of this study was to develop standard operating procedure (SOP) for its manufacturing stages.
Materials and Methods: Total 18 batches were generated for the optimum working process related to the powder size, quantity of binder, granulation, temperature and duration for drying and compression on the basis of trial and error. All the batches were assessed for friability, hardness and disintegration time and final ideal batch was selected
on the basis of normal set parameters. Ideal working condition was documented as SOP for manufacturing procedure
and final ideal batch was again repeated to check the reproducibility. Result was analyzed by calculating mean ± SEM
(Standard error of mean).
Results: Friability (%), hardness (kg/cm) and disintegration time (Minutes) of selected final ideal batch and repeated final ideal batch was (0.0730±.01764, 0.09±0.0057), (4.10±.050, 4.03±0.087) and (26.16±0.5376, 25.57±0.4860) respectively and it was found within the set limit. Pre-compression parameters were fine, weight of tablet was 793.7 ± 4.755 mg and weight variation was <5%.
Conclusions: This work may be of utility in improving the quality when comparing parameters as it shows reproducible results. This SOP may be used for future reference for production of ideal Qurse Tabasheer quality wise. Key-words: Standard manufacturing procedure, Qurse Tabasheer, Unani, Tablets Introduction
compiled1. There has been an exponential growth in
in many countries of the world such as Chinese
origin and lesser adverse effects 2. Majority of the
The traditional system of medicine is being practiced
medicine (TCM), Indian system of medicine (ISM) (Ayurvedia, Unani and Sidha), African folklore etc.,
where the remedies are thoroughly documented and
herbal medicine in last few decades, due to natural
remedies of Indian system of medicine are based on plants / plant products and few on animal and mineral
products. In manufacturing process, a lot of variation
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