Intervenciones para la prevenci贸n de ca铆das en personas de edad avanz...
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Outcomes
1. Rate of falls. 2. Number of people falling.
Notes
Flowchart in Figure 1 shows N = 139 randomised with 70 in intervention group, but Table 1 (baseline characteristics) shows N = 138 randomised with 69 in intervention group.
Risk of bias Item
Authors' judgement Description
Adequate sequence Yes generation?
Randomised in blocks of 20, by computer programme.
Allocation concealment?
Yes
Randomised independently of the investigators.
Blinding? Falls
Yes
Falls reported by participants who were blind to their group allocation (placebo-controlled trial).
Low risk of bias in recall of falls?
Yes
Falls recorded in falls diary which was reviewed at follow-up assessment.
Dukas 2004 Methods
RCT. Losses: 57 of 378 (15%).
Participants
Setting: community, Basel, Switzerland N = 378. Sample: volunteers recruited from long term cohort study, and newspaper advertisements (52% women). Age: mean 75 (SD 4.2). Inclusion criteria: aged over 70; mobile; independent lifestyle. Exclusion criteria: primary hyperparathyroidism; polyarthritis or inability to walk; calcium supplementation > 500 mg/d; vitamin D intake > 200 IU/day, active kidney stone disease; history of hypercalcuria, cancer or other incurable diseases; dementia, elective surgery planned within next 3 months; severe renal insufficiency; fracture or stroke within last 3 months.
Interventions
1. Alfacalcidol (Alpha D3 TEVA) 1 mcg per day for 36 weeks. 2. Placebo daily for 36 weeks.
Outcomes
1. Rate of falls. 2. Number of people falling. 3. Number of people with adverse effects. Other outcomes reported but not included in this review.
Notes Risk of bias Item
Authors' judgement
Description
Adequate sequence generation?
Yes
Randomised using "numbered containers"; numbered and blinded by independent statistical group.
Allocation concealment?
Yes
Numbered and blinded by independent statistical group.
Blinding? Falls
Yes
Falls reported by participants who were blind to their group allocation (placebocontrolled trial).
Low risk of bias in Unclear recall of falls?
Questionnaire about incidence of falls at clinic visits (4 weeks, 12 weeks, and every 12 weeks subsequently to 36 weeks). Subjects asked to record falls in a diary and to telephone within 48 hours of a fall.
Elley 2008
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