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Your optimal partner for Particle Therapy

01 Highlights and Key Features

CNAO has been working in the Particle Therapy (PT) field for more than 13 years and is now ready to put its expertise at your disposal, according to your several needs.

CNAO Foundation is a state-of-the-art clinical and research center and aims to be the most advanced facility in the world using the latest technologies. The attraction of the collaboration with CNAO is our unique experience over the course of more than 13 years of treating patients with hadrontherapy, both protons and carbon ions; moreover, CNAO has gained unique experience in the construction of a clinical facility that houses a synchrotron, and in the near future, is ready to host a new protontherapy with gantry and a new machine to deliver Boron Neutron Capture Therapy (BNCT), a challenging and unique approach for the treatment for metastatic tumors.

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Since the beginning, CNAO has leveraged on its strong network, CERN, GSI, INFN, Etoile, LPSC, mentioning the most important ones. CNAO’s experience in clinical activity began in 2005, during the construction phase, when the first clinicians were directed to Japan to observe and learn from the already existing Hadrontherapy Centers. The study, design and organization of 18 experimental protocols for hadrontherapy followed the initial phase.

Since 2011, CNAO has treated more than 5000 patients, within an effective average of 600 patients per year. Our Center is now considered a point of reference in hadrontherapy for the training of the clinical staff becoming also a very demanding partner for participation in funded projects. CNAO regularly shares its experience and results of its clinical activity through seminars and conferences, both nationally and internationally.

In addition, CNAO is officially identified as a certified manufacturer of its own medical devices, consisting of a complete particle accelerator, extraction beam lines and some human-oriented systems, customized to the specific needs of hadrontherapy treatment rooms.

The medical devices produced by CNAO are CE certified and approved by the ISS (Istituto Superiore di Sanità),

The continuous updating of any existing plants is periodically submitted to the recognized authorities by submitting a revision of the technical documentation.

Today we take a further step: the foundation of our new company, subsidiary to Fondazione CNAO, entirely participated by CNAO and called CNAO next, whose statutory goals are developing and transferring knowledge and skills coming from CNAO’s experience.

CNAO next can help you in realizing new centers, putting at your disposal the best of expertise and our most skilled personnel in the different topics related the start- up of an hadrontherapy Centre.

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What is

The National Center for Oncological Hadrontherapy (CNAO) in Pavia (Italy) is a multi-ionic facility at the forefront of technology. CNAO’s accelerator technology was the first realization of the concept behind the Proton Ion Medical Machine Study (PIMMS), held at CERN in the late 1990s. The construction of the accelerator was carried out from 2004 to 2010, starting from the project of the Tera Foundation, with the strong contribution of INFN (National Institute of Nuclear Physics), CERN, GSI and many other national and international institutions.

CNAO is a manufacturer of Medical Devices (Directive 93/42 EEC) certified for the production of a CE marked hadrontherapy implant with protons and carbon ions. This qualification was obtained not only on a documentary basis, but also after a long series of successfully completed physical, radiobiological and clinical studies in 2013.

During the years of construction, commissioning and operation of CNAO, its staff has acquired many skills in the key area of the PT.

We could mention:

RADIOTHERAPY

ACCELERATOR PHYSICS AND CONTROL SYSTEMS

MEDICAL PHYSICS

CIVIL AND PLANT ENGINEERING MANAGEMENT AND PLANNING

BIOENGINEERING

RADIATION SAFETY

MEDICAL RADIOLOGY

REGULATORY AFFAIRS AND RISK MANAGEMENT

COMMUNICATION AND DISSEMINATION

ECONOMICS AND FINANCE

LEGAL EXPERIENCE IN THE ADMINISTRATIVE AND HEALTH FIELDS

COMPUTER SCIENCE

RADIOBIOLOGY

RESEARCH IN HADRONTHERAPY

DEVELOPMENT OF MEDICAL DEVICES

AI

CNAO in the next year will represent a unique Centre in the world, providing treatments with carbon ions, protons (with a dedicated synchrotron and a rotating gantry with a large irradiation field), Boron Neutron Capture Therapy (BNCT) and new ion species (Oxygen, Helium, Lithium) in order to guarantee personalized treatments, according to the tumor histology.

A hadrontherapy center is a complex system equipped not only with accelerator technology, but also with medical technology, which includes beam delivery, patient positioning and verification devices, treatment planning and Monte Carlo software, bioengineering devicesand medical services.

03

The born of a particle therapycenter: the MedAustron case

The Austrian center of MedAustron is an example of how we can support you in the design and development of a proton therapy and/or a carbon ion centre and accelerator

Together, these systems contribute to the optimization of clinical delivery. At CNAO plant, medical technology has been customized according to clinical specifications, assembling and integrating hardware and software components that are sometimes available on the market, but often made for it. CNAO has guidelines to identify the best solutions for the design of new CNAOMed proposal for your country.

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The design of the center in Wiener Neustadt was improved and customized to MedAutron’s needs by further collaboration between MedAustron and CERN. In just a few months, MedAustron has become operational in the treatment of patients and represents version 2.0 of the PIMMS concept design.

At CNAO, a driving design criterion was to compact the space needed for high technology in order to cope with the size of the site.

The layout of MedAustron is wider, and fewer constraints have been adopted. The ion sources and the injector linac are located on the outside of the synchrotron ring and therefore accessible independently of the main accelerator. The design of the high-energy light lines adopts the PIMMS approach, and several modules are inserted for beam manipulation. This solution, at the price of larger size and cost, is preferred to facilitate operation, commissioning and to increase the robustness of the design.

The two solutions highlight the flexibility of the design of the CNAOMed, a project within which the MedAustron center was born, which can be adapted to very different layouts and driving design criteria.

As demonstrated by the success of the Austrian Center, the final choice for your facility can be optimally adapted to the needs and requirements of your project. This flexibility also allows new components to be incorporated into the project such as a “Lego model”. This is evaluated by other structures with an interesting perspective (e.g. new ionic species).

Conclusions

The model we propose and for which we will provide support for the implementation has already demonstrated the ability to produce high-quality results at competitive costs in Italy and Austria. We are confident that from a cost point of view our offer is very competitive and will guarantee a unique flexibility in design and updating because the team involved in the implementation brings together first-rate skills available in the world today.

Nowadays, the construction of a carbon ion hadrontherapy center is still far from being a simple commercial activity. The number of carbon ion centers is very limited; Technical choices are still evolving and do not lend themselves to being crystallized in contractual choices made at least five years before their use.

Very few experts in the world have the clinical experience with carbon ions and, as a result, the ability to team up and collaborate with existing institutions in this field is of paramount importance. All these considerations lead us to consider our proposal as the best approach to ensure the present and future success of your new hadrontherapy center.

How we can help you: CNAO consulting services

CNAO’s experience can thus represent your best choice both in terms of consulting for a new PT facility and for designing, producing and installing high technology components. We may provide you with specific advice and supervision in the following non-exhaustive lists of services.

TRAINING OF TECHNICAL STAFF

Support in the development of the accelerator maintenance activity plan, training of technical staff for all high-tech items.

TRAINING OF CLINICAL STAFF FOR THE CENTERS UNDER DEVELOPMENT

CNAO is well connected to the international Particle Therapy community and has already organized and provided trainings for several topics dealing with PT and related topics. The training of your staff is provided both in the pre-clinical phase and in the start of clinical activity at your Facility.

THROTTLE DESIGN

CNAO’s design will be customized according to your needs in terms of accelerator extraction beam lines and treatment rooms.

RADIATION SAFETY SERVICES

(Monte Carlo simulations, support in the preparation of documents for authorizations, survey) Shield sizing, radiation monitoring and operational safety, support in the preparation of documents to be submitted to the competent Authority.

SUPPORT TO THE DESIGN AND DEVELOPMENT OF PROTON THERAPY

AND/OR

A CARBON ION CENTER

We can provide a complete solution, designing, building and supporting the operation and maintenance of the PT facility.

PROJECT MANAGEMENT, CONSTRUCTION

MANAGEMENT AND RELATED SERVICES

The support to the management of the project is intended both in the coordination of the construction of the plant and in the installation of the accelerato and in the commissioning, supporting you until the start-up of the new structure.

ANCILLARY SERVICES

Support for the development of the business plan and the strategic marketing and communication plan.

ALLOCATION

BUDGET AND RESOURCE

MEASUREMENT AND EVALUATION

STRATEGIES FOR PATIENTS

ADVOCACY

CONTENT STRATEGY

BRAND POSITIONING MARKETING GOALS COMMUNICATION CHANNELS

TARGET AUDIENCE SEGMENTATION

MARKET ANALYSIS

A strategic marketing and communications plan in the healthcare sector requires a comprehensive approach that considers the unique challenges and objectives of the center/institution, considering the following key elements:

MARKETING & COMMUNICATION

STRATEGIC

Starting from our experience, we are able to support in the drafting of technical data sheets, technical requirements and contracts related to the procurement of accelerators, medical device components and designed architectural infrastructures.

DATA SHEETS FOR TENDERS RELATED TO HIGH-TECH COMPONENTS (HT), CONSTRUCTION AND CONVENTIONAL SYSTEMS

SUPPORT IN THE DRAFTING OF TECHNICAL DOCUMENTS AND TECHNICAL

Support in the design of clinical protocols, patient selection and treatment criteria, optimization of patient workflow, reporting and data management.

(including proton therapy for pediatrics).

SUPPORT IN THE DESIGN OF CLINICAL PROTOCOLS AND CLINICAL PROCEDURES

CNAO provides you with the clinical facility for the treatment of Romanian patients selected by your clinicians, before the start of your facility and your clinical staff will work alongside the CNAO clinical team.

OF YOUR PATIENTS WITH YOUR STAFF AT THE CNAO BEFORE STARTING THE NEW FACILITY

POSSIBILITY TO START THE TREATMENTS

The design of the structure and the consequent construction activities will comply with national requirements and regulations, in terms of regulatory affairs. Our support includes ISO9001, 13485 and Joint Commission International for clinical procedures.

SUPPORT FOR REGULATORY AFFAIRS AND OBTAINING CERTIFICATIONS

CNAO’s experience can thus represent your best choice both in terms of consulting for a new PT facility and for designing, producing and installing high technology components. We may provide you with specific advice and supervision in the following non-exhaustive lists of services.

How we can help you: CNAO NEXT consulting services

06 Radiation Safety Services

CNAO next supports in the management of radiation safety services

CNAO has been drawing on its state-of-the-art experience in shield sizing and radiation protection authorizations since the beginning of the design and construction of the CNAO synchrotron. In addition, in the last 4 years the Department of Radiation Protection, led by the Radioactive Safety Expert Eng. Michele Ferrarini has been involved in the design of the shielding, the safety of people and the environment for the new high-level technologies that will be installed: a proton accelerator with gantry and a Facility for Boron Neutron Capture Therapy.

Thanks to our know-how in having designed the CNAO shielding layout and supported a new Italian structure in the sizing of its shielding and in the request for the related authorization, CNAO next will provide its consulting support in the following thematic areas:

• Shield Verification Calculations with Monte Carlo Methods

Each facility is unique in terms of technology, local regulations, treatment delivery modalities, clinical workload, and other parameters. Particular attention to country-specific dose rate requirements, which can lead to different radiation shielding designs for specific sites.

• Emissions and environmental aspects

Activation by timely radiation of air, water, and soil is a typical concern. An assessment of the impact of the release of any activated material is important to convince the regulatory body. Activation calculations are based on a combination of Monte Carlo simulations, information from regulatory bodies and other standards, and customer information about local site conditions.

• Air Activation, Groundwater Activation and Soil Activation Study

Velocity-based drains require information from the customer about the ventilation design. Local limits and regulations for radioactive discharge must be provided by the Customer.

07

Conclusions

CNAO next: the best choice for your patients and your research programs.

Nowadays, the construction of a multi particle therapy center is still far from being a simple commercial activity. The number of such centers is very limited; The technical choices are still evolving and do not lend themselves to being crystallized in contractual choices made at least five years before their use.

Very few experts in the world have the clinical experience with carbon ions and, as a result, the ability to team up and collaborate with existing institution in this field is of paramount importance.

All these considerations lead us to consider our proposal as the best approach to ensure the present and future success of your new hadrontherapy center.

The model we propose, illustrated in the rest of the document, is also competitive in terms of costs and flexibility of choice.

Furthermore, the implementation of the accelerator for Boron Neutron Capture Therapy represents an innovation from a technical and scientific point of view that will allow us to open up national and international research avenues and collaborations to new partners.

The expertise deriving from the realization and use of this accelerator will also be put to use by new centers interested in this innovative experimental technique.

We are confident that from a cost point of view our offer, both from a technical-scientific point of view and from a training and management point of view, is very competitive and will guarantee a unique flexibility in design and updating because the team involved in the implementation brings together first-rate skills available today in the world.

The elements offered by CNAO next at a glance:

Elevating Particle Therapy Excellence - Unmatched expertise, from state-of-the-art facility design to comprehensive staff training, all within the framework of the latest and most advanced technologies. Unparalleled innovation and expertise within the BNCT, used experimentally for the first time in Italy at CNAO.

In conclusion, we believe that CNAO next’s proposal can be very convenient for your facility in terms of cost, timing and adaptability to present and future needs. It allows for the inclusion of local expertise that will be needed in future clinical and research developments.

CNAO next guarantees the best model to deal with a non-standard undertaking to build a structure that has the “duty” to be at the forefront of technology, clinic and research for the coming decades.

The main advantage of on-the-job trainin is to participate in the complete development of the patient’s clinical path, from recruitment to the follow-up phase, obviously passing through the complete hadrontherapy treatment, session after session, day by day.

After the preliminary evaluation of the clinical documentation, the trainee will attend the first clinical visit, and together with the Medical Physicists, will design the best individual care plan based on the CT/MRI imaging acquired by the Radiologists and Radiotechnicians. The treatment is divided into a variable number of sessions, during which Nurses and Radiation Therapists are involved in patient care and Bioengineers, Medical Physicists and Radiotherapists are always ready to intervene in case of need. The anesthesiologist intervenes in imaging procedures when contrast medium is used or in the case of pain therapy to be dispensed. They are also crucial for the treatment of pediatric patients under anesthesia.

Psychologists and health care assistants are other clinical support figures who assist the patient at different levels of need during the treatment.

6.3 Clinical Training (CAT) start-up phase

After the preclinical activity, there is a two-year period of on-site staff assistance with the direct presence of CNAO staff in your Facility, to assist and help in the operations for the start-up phase.

The total commitment that CNAO can make available to you for training is represented by 48 man-months, mainly related to medical activities, medical physics, radiotherapy technicians and nurses, but also including hours of other specific professional figures.

All activities will be regulated according to the laws on the protection of personal data.

On request, the training of the support team will be customized according to specific needs and can be extended to other professional profiles of the staff:

• administrative staff, who take care of registration, appointment booking, reimbursement procedure;

• Health Director and Regulatory Office, who is in charge of relations with national and local institutions;

• operational technicians, in charge of managing the plants associated with the production of beams;

• radiation protection personnel and risk managers;

• Marketing and Communication Office.

At the end of the overall training period, each participant will be awarded a certificate of graduation attendance at the Clinical Internship.

The CNAO team plans to work alongside you to put in place an effective patient recruitment network, thanks to the experience gained over several years of national and international collaborations with the main national and international hospitals and health institutes.

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05 Training: a detailed Proposal

In the following section there is a brief and specific description of the clinical internship, from the pre-clinical training activity to the full running phase of Particle Therapy, including BNCT.

6.1 An overview of CNAO’s educational offer

Considering your request regarding the launch of your new particle therapy center in your country, we offer you below a brief presentation of the skills that we will be able to make available to you for a period of training in CNAO and, at your request also on site.

1. CONSULTING FOR THE SIZING OF PERSONNEL NEEDS

Proper staffing is necessary or your business and operational plan. Thanks to CNAO’s experience and in order to start the clinical activity, we are able to help you in the allocation of staff from the initial phase to the full operation, based on your objectives in terms of patient treatment and research activities. We can assist in scheduling the recruitment and plan their training period before they become fully operational.

2. CUSTOMIZED TRAINING

In addition, we can customize a training course for each professional profile, organized with a period of preclinical experience at CNAO (in the subsequent PCAT, acronym for Pre-Clinical Activity Training) and a period of on-site training (in the subsequent CAT, acronym for Clinical Activity Training). The training is aimed at the following professional profiles, which are the categories most involved in the patient clinical path:

Medical Director

Radiation Oncologist

Bioengineers

Medical Physics Coordinator

Medical Physicists

Technical Engineer

Radiation

Technician Coordinator

Radiation Technicians

Radiologist

Psychologist

Anaesthetist

Nursing and staff support

The structure of the training proposal will be subjected to further discussion and adaptation to your needs. Below is a rough proposal based on our experience to optimize the quick and smooth start-up of the structure. The full duration of the proposed training is spread over an average period of 4 years: initially 2 years to get to the first treatment of the patient which represents the preclinical phase (PCAT), followed by 2 years of on-site assistance (i.e. in one’s own country) and collaboration/optimization of clinical activity (CT).

involved. The total period for each professional is estimated at 6 months (negotiable). The first professional profiles to be trained will be the coordinators of the department, representing the key functions of the new Structure: Medical Director and Medical Physics Coordinator. This will occur at least two years prior to the patient’s first treatment. For these categories there is a total training period of 6 months, consecutive or organized in two/three separate sessions of stay at CNAO during the two years. During the first period of PCAT training, CNAO will provide each professional category of trainee with a QUALIFIED TUTOR, who will organize both specific and dedicated theoretical training and training-on-the-job, After this phase, all the other members of the start-up team will be hosted in CNAO for an average period of 6 months to assist in carrying out the clinical activity.

Effective training can be organised by providing one tutor for every two trainees. For each professional category, one day per week of the tutor will be reserved exclusively for classroom training and specific activities and needs. During their staying at CNAO, trainees will have access to all clinic-related meetings, such as clinical case discussions or multidisciplinary consultations. This type of training will ensure that they gain skills in: • clinical assessment of eligibility conditions for each protocol;

• additional procedures to be carried out for the best assessment of eligibility;

• different phases of the Therapeutic Care Protocol for different protocols; • needs for specific protocols;

• collection and management of clinical data.

6.2 Preclinical Activity Training (PCAT)

Pre-clinical training will be held at CNAO. All categories will be

Each training program can be customized to your specific needs.

BELOW IS THE LIST OF SENIOR CNAO STAFF WHO WILL COORDINATE THE TRAINING.

FOTO MEDICI

04 From training to regulatory aspects

CNAO next will also cover the training of your clinical staff for your Center already during the creation phase and give you the possibility of starting the treatments of your patients with your Staff at the CNAO before opening the new facility, supporting you also for regulatory affairs and the possibility of obtaining certifications

The possibility of treating your patients, selected by your clinicians, at CNAO, during the construction of your center, and the possibility for your clinicians to follow their patients, would represent a unique opportunity for your clinical staff to be involved in training programs based on systems very close to the final operating conditions. This opportunity represents an opportunity to reduce the learning phase of the staff subsequently involved in the management of the hadrontherapy center in your new facility.

TRAINING OF TECHNICAL STAFF

During the life cycle of particle therapy centers, the necessary further hardware and software developments are usually time-consuming and costly. Close cooperation between all partners will allow for optimal use of resources for the benefit of all parties. The team and organization put in place to assist you during the building of your new facility are exceptionally experienced. The involvement of a local laboratory, expert in accelerator technology and applications will allow to count on a local pillar. This local laboratory can contribute with the valuable knowledge of local producers, contacts with local companies and recruitment of qualified people useful for the project. It can also provide the new centre with long-term support, collaboration and research.

The management model that will be applied in this project is very similar to the one successfully tested at CNAO: the creation of a nucleus of young and enthusiastic people who will grow up in the shadow of the experts and then take care of the management, maintenance and modernization of the new structure. With this approach, it is also possible to make the decision on the maintenance model at a later stage; whereas, in the case of a purely commercial solution, this decision will have an impact on the entire life of the centre.

SUPPORT FOR REGULATORY AFFAIRS AND OBTAINING CERTIFICATIONS

Coordination with the Regulatory Agency and support in the structuring of the necessary documentation: A well-prepared permit application can save the client time and money.

Preparation of the application file for authorisation

The file typically contains organizational details about the owner/operator, environmental aspects of the site where the particle therapy center will be built, and safety-relevant information. The amount of documents that need to be submitted during the permit application can range from a few letters and reports, to different folders of safety assessments, depending on the local regulatory requirements.

03 Project

management, construction management and related services

How CNAO next will support you in realizing the project and the services management

CNAO next will be responsible for the final design, assembly, commissioning, and performance of the beam to meet your needs. We will also liaise with the authorities to obtain the necessary authorisations for the management of the new facility. In this regard, the record of obtaining the CE certification which enables the use of CNAO medical device for any pathology that has an indication for hadrontherapy, already obtained by the Foundation.

The entire project will be completely customized according to your needs, starting from CNAO’s experience and therefore relying as much as possible on the technology already in use, obviously with due attention to technological evolution and future developments.

The implementation of the various systems will be carried out through a careful selection of specialized suppliers, favoring local companies also to facilitate future maintenance subcontracts.

The construction of conventional buildings and facilities will most likely be subcontracted to a local company sufficiently qualified to deal with the construction of high-tech plants and large infrastructures.

During the construction of the centre, a parallel group will be created, which will associate young engineers, physicists and technicians with the core of experts. Priority will be given to hiring local and regional experts, as these people will be the staff responsible for the maintenance and operation of the new facility.

Specialists will gain experience with internships at CNAO and during all phases of the center’s implementation. When the center is up and running, they will be the first experts to intervene to ensure preventive and extraordinary maintenance.

The source of the young people will be “primarily” and essential to ensure continuity on the overall life

of the structure. During the maintenance activities, the group will be supplemented by a suitable set of subcontractors, not necessarily chosen from among the companies participating in the construction, necessary to complete the coverage of all the interventions. The future group in charge of managing technology and maintenance will be organized into a team that could be integrated into the structure of the hadrontherapy center, or it can remain separate in full responsibility for providing high-quality bundles to clinical and research customers.

The chronological plan for the construction of the center will see a first phase of executive design of the center according to the requirements established by your team. The design will reuse as much as possible the systems and solutions adopted for CNAO and the centre of MedAustron and this will speed up the design phase and start the procurement of long flagship products (magnets, power supplies, linacs).

The final design will define the layout of the buildings and the specifications of the conventional plants and this will kick off the procurement of civil engineering.

The experience gained in the implementation of CNAO and MedAustron will be useful to reduce planning time and focus attention on the critical elements to ensure the performance of the plants. Commissioning will be facilitated as the third infrastructure is built on the same original design.

02

The new facilities: new Protontherapy

Boron Neutro Capture Therapy (BNCT)

Among the new facilities, CNAO foresees the development of new instrumentation with particular equipment for protontherapy and for Boron Neutron Capture Therapy (BNCT).

BNCT is a promising experimental radiotherapy technique, already used in research in some European and around the world countries, which will be introduced in Italy for research in the treatment of invasive, untreatable and metastatic tumors right at CNAO.

A new a proton accelerator will be installed at CNAO with the setting up of a treatment room with a gantry. The further clinical option, made possible by the gantry, allows the tumor to be hit from different directions, reducing the treatment times.

Furthermore, a small particle accelerator for the production of neutron beams will also be installed, used for the development of BNCT. BNCT is an advanced form of radiotherapy that combines the biological

targeting precision of a benign boron-10 (10B) target drug with a neutron source to deliver a therapeutic treatment dose only in the cells that contain 10B. The neutrons captured by 10B then generate shortrange alpha and lithium particles in the cancer cells that directly create a double DNA strand break in the cancer cells, outperforming other conventional cancer treatments.

The implementation of these new facilities will make it possible to provide these services externally as well, supporting the entire process of design, construction, maintenance and staff training within the new centres. This will allow us to export expertise to these other centers, which could become research centers in these frontier areas of hadrontherapy.

This will allow the hadrontherapy network to be expanded and consolidated, generating networking and opportunities for exchange and possible interactions in the field of international research, including the study and application of BNCT.

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From CNAO to CNAO next, how the existing expertise in CNAO has enabled the creation of CNAO next: your optimal partner for Particle Therapy –from the design to the training of personnel within the most sophisticated technologies

CNAO next:

Elevating Particle Therapy Excellence - Unmatched expertise, from state-of-the-art facility design to comprehensive staff training, all within the framework of the latest and most advanced technologies. A team of experts plans to work alongside you to build your new particle therapy facility.

CNAO next is an independent company, born in 2024 from the expertise and wide range of action of CNAO Foundation, which operates in the field of precision therapies and hadrontherapy. Its goal is to promote innovative and technological therapies through research and the weaving of solid networks with diversified partners, pertaining to the world of technology, medicine, care and industry.

All this by providing technical consultancy services and promoting the development and transfer of technology such as, the design and construction of accelerator machines and their components, the design and implementation of control, safety, positioning,

verification, monitoring, management and treatment systems of the patient, the definition of clinical and pre-clinical protocols, radiation protection systems, the development and delivery of new therapies

The creation of a multidisciplinary scientific and cultural network will allow a virtuous exchange for all parties to support the creation of new research and operational realities in the field of precision medicine and hadrontherapy, included the application of a new experimental technique:

Boron Neutron Capture Therapy (BNCT).

Very few experts in the world have the clinical experience with carbon ions and, as a result, the ability to team up and collaborate with existing institutions in this field is of paramount importance. Here we present the best approach to ensure the present and future success of your new hadrontherapy center.

From facility design to personnel training inside the most sophisticated technologies