This is a startup research project supported by the Stimuleringsfonds. The starting motive behind this work is spotting a light on the hazard effect of chronic stress endured by alienated figures in society. The alienated figures here are referred to by individuals with a refugee experience for example, or other forms of alienation that cast heavy experiences (that many people suffer from during crisis). Here chronic stress is investigated biologically; how it affects the nature of the body, the cells, DNA and genes. In another part of the research, spatial and innovative understandings/examples are gathered to pinpoint how space can be used as a tool to hack human perception and cognition, affecting human bodily health and stress emotions. The surrounding environment is tackled as an ‘extended mind’ of the body. And spatial design is presented with a nature of ‘wider inclusions’, where biological and technological understandings are included in the fabrication of future spatial contexts.