Menzies Summer Bulletin 2017

#91 summer 2017

Three reasons to celebrate $2.4 million boost for arthritis, stroke and MS research at Menzies

The Menzies Director, Professor Alison Venn, said the grants reflected the breadth of research taking place at Menzies.

“We focus on research that will have a significant benefit for the Tasmanian community, and beyond. These projects have the potential to make a difference in the lives of thousands of people. They reflect our drive for innovative research that is focused on impact in the community,” Prof Venn said.

The three projects to receive

the highly competitive funding are: $1.3 million for a trial of the anti-inflammatory drug diacerein to treat knee osteoarthritis. Almost 60 per cent of people with knee osteoarthritis have joint inflammation and are likely to experience pain and rapid destruction in the joint. This clinical trial, led by Dr Dawn Aitken, will test whether diacerein reduces pain and joint damage in patients with inflammatory knee osteoarthritis. $665,000 for investigation of non-invasive magnetic stimulation to promote re-insulation in the brain.

This project, led by Dr Kaylene Young, will determine whether non-invasive magnetic stimulation can promote

The starting line from this year’s Menzies 5km Walk.

Walk the Bridge for research at Menzies We will be off and walking again on Sunday February 18 for the Menzies 5km Walk, which is part of the 2018 Bank of us Run The Bridge event.

Peter Mathew

Menzies research into knee osteoarthritis, stroke and multiple sclerosis has received a major boost with the announcement of more than $2.4 million in funds from the National Health and Medical Research Council.

Exciting times are ahead for Dr Seana Gall, Dr Dawn Aitken and Dr Kaylene Young.

insulation repair in a pre-clinical model of a diseased brain. This funding will further strengthen the large and integrated program of research that continues 20 years of expertise in multiple sclerosis at Menzies.

We focus on research that will have a significant benefit for the Tasmanian community

There are two great reasons to get behind the Menzies 5km Walk – you will be doing your physical and mental health a favour and the Bank of us Run The Bridge organisers will donate part of your entry fee to medical research right here.

The inaugural Menzies 5km Walk in 2017 attracted 539 entrants and this year we’re aiming for an even bigger group of walkers.

Just imagine crossing the iconic Tasman Bridge

$436,000 for reducing delays in treatment of aneurysmal subarachnoid haemorrhage, a rare but devastating form of stroke that kills at least 30 per cent of sufferers within one month.

This project, led by Dr Seana Gall, will determine the optimal times for treatment to increase discharge home, reduce complications and improve survival for people who have suffered this type of stroke.

Work on the projects will begin in early 2018.

on a Sunday morning – taking in the view of our beautiful city and mountain while exercising at your own pace with family and friends!

Former Menzies research student in cardiovascular disease, and recently announced Rhodes Scholar, Henry West is an ambassador for the 2018 Bank of us Run The Bridge.

“It’s no secret that a risk factor for cardiovascular disease is being sedentary.

Events such as this provide

people an opportunity not to just complete one event, but to establish regular lifestyle choices to be active,” he said. “With the weather warming up, there’s never been a better time to put one foot in front of the other.”

Entries are now open at hobartrunthebridge.com.au

Menzies Bulletin Summer 2017 1

Welcome to the Summer Bulletin for 2017 This is the end of my second year as Director of Menzies and it gives me great pleasure to look back over this period and reflect on what we have achieved and the groundwork we have set down for the future.

We are focusing more than ever before on research that has a clear path to impact in the community

Our contribution to the medical research literature is higher than ever before, our track record for competitive grant income remains strong and the number of young scientists we are training as PhD students is at an all-time high. We are focusing more than ever on research that has a clear path to impact in the community, and doing this by regular and meaningful engagement with government, the health sector and nongovernment organisations.

One of our achievements this year has been to bring our many streams of multiple sclerosis research into one

cohesive program focused on the translation of research into practice – in other words, focused on material outcomes as soon as possible for people living with this disease. We are prioritising a cross-disciplinary approach that will bring together ideas and different streams of research, and I am confident that as a result we will see many good news stories from our MS work in the next few years.

From the beginning of 2018 some administrative changes will bring us closer to our colleagues in the university’s School of Medicine, the School of Health Sciences and the

Summer Appeal

Help ease the pain of osteoarthritis Our Summer Appeal for donations towards osteoarthritis research is now under way.

Osteoarthritis is the most common form of arthritis and joint disease worldwide and is a leading cause of pain and impaired function among working age and older adults. Over 1.9 million Australians suffer from osteoarthritis and the cost to the economy is approximately $3.75 billion per year.

There is currently no cure or therapeutic intervention that simultaneously improves the structure of a joint and the debilitating

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How to donatE

Wicking Dementia Research and Education Centre. Each entity will remain distinct but we will be collaborating more closely and sharing some resources where this makes sense, all under the umbrella of a new College of Health and Medicine. I look forward to the benefits that these closer ties will bring to Menzies and the university as a whole.

I would like to extend my thanks to all who have contributed to Menzies this year – the staff, students, volunteers, members of the community and our colleagues within the health, medicine, non-government and research sectors. I hope that you will all spend the festive season and summer break safely and happily with those closest to you.

Regards, Professor Alison Venn Director

A very Menzies Christmas In need of last-minute Christmas cards?

Design: Cathy McAuliffe

• Go to the Donate tab at menzies.utas.edu.au, or • Return the donation slip attached to this Bulletin, or • Call 1800 638 124 or 03 6226 7700

pain and symptoms of osteoarthritis. Our current osteoarthritis research at Menzies includes a project led by Professor Graeme Jones (pictured) and Dr Feng Pan, who are looking at the drug venlafaxine.

One trial so far has found a promising effect from venlafaxine on

Menzies Bulletin Summer 2017

osteoarthritic pain and function. This trial is an important proof of principle study. However more thorough trials are required to assess its effectiveness. You can help us continue vital research into venlafaxine and osteoarthritis by making a gift to our Summer Appeal today.

Purchase a pack of beautiful Menzies Christmas and greeting cards. All proceeds go directly to medical research at Menzies.

Packs of 12 cards are just $10.

How to order

Online at www.menzies.utas.edu.au/cards Call 03 6226 7700

Visit the reception desk at the University of Tasmanian Medical Science Precinct, 17 Liverpool St, Hobart, during office hours Visit Fullers Bookshop at 131 Collins St, Hobart or the Charity Christmas Card Shop at St David’s Cathedral, 23 Murray St, Hobart Card range includes original artworks donated by Tasmanian artists Bert Aperloo, Lorraine Biggs, Barbara Cauvin, Sara Ferrington & Dan Kershaw, Brenda Haas, Richard Klekociuk, John Ingleton, Carol Maney, Kate Pietkowski, Jane Richards, Michael Weitnauer, Stewart Wells and Katy Woodroffe. Thanks to our print and design partners - Winc, Mercury Walch and The20

University celebrates Menzies’ contribution in MS research A team of six Menzies researchers working on multiple sclerosis has received this year’s University of Tasmania Vice-Chancellor’s Award for an Outstanding Research Program.

Community engagement work supporting Menzies cardiovascular disease research was also recognised at the awards.

Menzies researchers and their collaborators have made significant contributions to understanding the genetic, environmental and lifestyle risk factors for both the development and progression of MS in a program of work that began in 1998.

Menzies MS research includes clinical work looking at the cause, disease progression and management of MS. Our

cell-based laboratory research is helping to lay a foundation for translation into drug therapies.

In the population health area, we manage Australia’s largest cohort study of people with MS (the Australian MS Longitudinal Study). This study provides other researchers, advocacy groups and government agencies with practical

Ms Kristyn Whitmore with the acting Vice-Chancellor, Professor Mike Calford.

information on how MS is impacting on people’s lives.

Menzies study coordinator, Ms Kristyn Whitmore, received the Vice-Chancellor’s Award for Outstanding Community Engagement. Ms Whitmore coordinates two cardiovascular studies – one which looks at the familial risk factors for heart disease and another that follows

the progress of patients leaving hospital after treatment for heart failure (TAS HELP). The award noted Ms Whitmore’s “sustained contribution to developing new and innovative tools and programs to engage patients in improved understanding of selfcare following heart failure”.

The University of Tasmania acting ViceChancellor, Professor Mike Calford (third from left), with the successful MS research team – from left, Professor Bruce Taylor, Professor Andrew Palmer, Associate Professor Ingrid van der Mei, Dr Jac Charlesworth, Dr Kaylene Young and Professor Leigh Blizzard.

AWARDS AND RECOGNItION

Award-winning student bound for Oxford Henry West, who completed his Honours year at Menzies while studying in the School of Medicine, has been named the 2018 Rhodes Scholar for Tasmania.

While at Menzies, Henry received the Institute’s Best of the Best Award recognising a journal publication. Working with his supervisor, Dr Costan Magnussen, Henry’s article looked at the impacts passive smoke exposure on children. As a Rhodes Scholar, Henry will undertake a PhD at Oxford University. His research will focus on

developing new imaging tools for examining blood vessels, enabling early detection of cardiovascular disease.

The Rhodes Scholarship recognises leadership, community service and extra-curricular activities as well as academic attainment.

Henry’s commitment to helping others goes beyond his academic research: he has spent more than six months in Uganda providing public health education and intervention, and volunteers locally with the Heart Foundation and a number of other organisations.

Dr Kaylene Young has received an Australian Research Council (ARC) Discovery Project Grant of $490,000 to investigate how myelinating cells alter brain circuits to facilitate learning.

This project, which is part of Menzies’ integrated research program on multiple sclerosis, aims to identify the brain circuits that receive new insulation and characterise the molecular mediators of this process.

Dr Andy Flies has received an ARC Discovery Early Career Researcher Award providing $365,000 in funding for a project that aims to develop a single-shot vaccine for the Tasmanian devil facial tumour disease. This project will focus on immune molecules that are revolutionising human oncology, and will develop techniques to understand and systematically test the function of these key molecules in Tasmanian

devils. Dr Flies is also part of a team with Dr Bruce Lyons and Emeritus Professor Greg Woods which has received an ARC Discovery Project Grant of $300,000 aiming to identify the escape mechanisms that Devil Facial Tumour Disease uses to avoid being killed by the immune system.

Dr Kimberley Pitman and Dr Lei Si have received NHMRC Fellowships. Dr Pitman will be investigating genetic mutation and multiple sclerosis and Dr Si will be researching the economic value of osteoporosis interventions.

Menzies motor neurone disease neuroscientist Dr Catherine Blizzard is the Tasmanian STEM Young Researcher of the Year.

This award recognises the achievements of the state’s leading young researchers working in the fields of science, technology, engineering and mathematics

(STEM). “This was a great honour as it demonstrates that my achievements are not only recognised in the STEM field but my contribution to the Tasmanian community is also valued,” Dr Blizzard said. “Tasmania has a small, invested community and a commitment to supporting up and coming STEM researchers is vital for our success.”

Professor Tania Winzenberg has received a national research award for GPs. Professor Winzenberg won the Peter Mudge Medal for Best Research in General Practice Presentation on October 29 at Gp17, the Royal Australian College of GPs’ annual conference in Sydney.

The medal is awarded for advancing the discipline of general practice and the goals of the RACGP. It recognises original research with potential to significantly influence daily general practice.

Menzies Bulletin Summer 2017 3

Researcher profile

Dr Rick Liu Senior Research Fellow in Eye Genetics

You have arrived at Menzies relatively recently...

gene therapy research program to prevent vision loss.

What were you doing before this?

I received a PhD in molecular biology from Taiwan and completed postdoctoral training at the University of Melbourne. I have a special interest in understanding how blood vessels grow under both physiological and pathological conditions. In 2012, I moved to the Centre for Eye Research Australia, where I established a

What is the current focus of your research?

My main research interest is genetics surgery, commonly known as gene therapy, which uses genetic materials such as DNA to treat and prevent diseases. My work also involves developing effective genetic vectors derived from viruses or nanomaterials, which can be used for gene delivery in the eye or other organs.

What are some of the recent findings from your work?

Recently, my research has expanded from traditional gene therapy to emerging genome editing approaches.

Our research team has successfully published a first clinically applicable genome modification method using a new genome editing tool, named CRISPR/Cas9, on the mouse retina, delivered by a viral vector. This work marks a significant step towards the translation of genome editing technology to future anticipatory or pre-emptive treatments for devastating genetic eye diseases.

What is the biggest challenge in your area of research?

Just as in life, the experimental results

don’t always follow the original plan, requiring us to invest more resources and time to keep the research going.

So how to get funding and recruit research

My work involves developing effective genetic vectors... which can be used for gene delivery in the eye or other organs. students is my biggest challenge at the moment. Another challenge is that our area of research is rapidly moving, so I need to keep catching up with new knowledge to keep my work updated.

What is the most interesting aspect of your work?

As a laboratory-based scientist, I can have any crazy idea as long as it helps us to better understand the disease or develop an effective treatment. For example, until 1972, no one really believed a virus could be used to carry genetic material into the human body, becoming a viable treatment for genetic diseases. I really enjoy the moment when the experiment comes out, as you never know what you’re going to find out – it may be an exciting finding that changes the way people manage their disease. It is also exciting that my job can take me to many countries, I meet great scientists, learn new knowledge and enjoy different cultures at conferences or meetings.

Thank you to all of our donors for your ongoing financial support and commitment to Menzies The following individual and community supporters donated for the first time between late September and mid-November 2017

Mrs Diane Bender Mrs Elizabeth Butler Ms Jacinta Hill Ms Judith Johnson

Mr Steve Lee Ms Anna Majdanska Ms Rachel Marchant Ms Rosalie Mitchell

Mrs Maria Phillips Ms Helen Plaister Mr Chris Rambert Ms Philippa Salmon

Mrs Catherine Sargeant Ms Karen Wilson

Listed below are our Everyday Angels – our supporters who make regular gifts to Menzies.

Mr Don & Mrs Margaret Goff Mr Geoffrey & Mrs Julia Goss Mrs Judy & Mr Trevor Grant Mr Garth & Mrs Brenda Haas Mrs Susan Haigh Mr Philip Hand Ms Tess Harvey-Mount Ms Judith Hastie Mrs Shirley & Mr Frederick Heath Ms Alison Hennessy Mrs Susan L Hinds Ms Di Hodel Mr John W Hudson Ms Shelley Hunter Ms Carol Hurst Mr Gary & Mrs Susan Jacobson Mrs Wendy Jefferies

Ms Dianne & Mr Raymond Jones Mr Raymond & Ms Dianne Jones Mrs Margaret & Mr Alan Keogh Ms Margaret Knight Ms Sabina Lane Mrs Terry & Mr Ian Law Ms Anne & Mr Anthony Le Clerc Ms R Lipscombe Mrs Jane & Mr Nicholas Lovibond Mr David T MacLeod Mrs Marie Magill Mrs Betty M Marshall Mr Dugald McDougall Mr Marcus McEwan Mrs Helen McKibben Mrs Frances Joan McKinlay Ms Kate McQuaid

Mrs Philippa Micklem Mr Sam Mollard Mr Peter Morgan Ms Wendy Noye Mrs Astrid A O’Toole Mrs Sally Oakley Miss Alison Parsons Mrs Jennifer A Parsons Kim Paterson Mrs Glenda Paton Mr Andrew J Pitt Mr Nathan & Mrs Christabel Porter Mrs Cleone M Probert Mrs Pamela Rabbidge Mr Alan & Mrs Jancis Rees Mrs Margaret & Mr Brian Richardson Mrs Jill & Mr Eric Robinson Mrs Frances M Russon

Mrs June Scott Mrs Susan Sluce Mr Richard & Mrs Gwynneth Sperring Mr Alex Stanelos Miss Amber C Sturges Ms Carmel Taylor Mrs Cynthia Tennant Mrs Brenda Triffitt Mrs Rosemary Van den Berk Mr Walter & Mrs Robin Verth Mrs Anne Warren Mr Peter Weldon Mr John & Mrs Kathlyn Wheatley Mrs Kathryn Whitchurch Ms Barbara White Ms Janice Wilson Mrs Elizabeth Woolley Hypertronics Tasmania

Mr Timothy Albion Mrs Teisha & Mr Aaron Archer Mrs Jennifer & Mr Lionel Banks Mrs Jan Barren Mrs Larissa & Mr David Bartlett Ms Janet Beadle Mrs Kathleen Bevis Mrs Pamela Blunt Ms Kathleen Brient Mrs Jane Burrell & Mr Lloyd Sokvitne Ms Jill M Cassidy Dr Susan R Cherry Mrs Emma & Mr Timothy Claridge Mrs Anita & Mr Michael

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Clarkson Mr Peter Cochrane & Ms Miranda Harman Mr A M Cornish AO Mr Robert & Mrs Gloria Cotgrove Mrs Diane & Mr Jonothan Davis Ms Moya Deigan & Mr John Borojevic Ms Carolyn Dunnewijk Mrs Patricia & Mr Donald Edwards Mr Josh & Mrs Felicity Ey Dr Derek & Mrs Elizabeth Findlay Mr Peter Fountain Mrs Beverley Geard

Menzies Bulletin Summer 2017

Driving donations for Menzies With the lure of scenic drives on warm spring days, two organisations recently held car shows to raise money for Menzies.

A range of classic and exotic cars, coaches and fire trucks, and even a 1910 wicker sidecar were among 150 vehicles on show at the Rotary Club of Moonah’s Festival of Wheels, which was held on Sunday 5th November

at the Derwent Entertainment Centre.

Apart from a great day out, there was another good reason to be there – the proceeds of $5000 were donated to men’s health research at Menzies.

On the same weekend in Ulverstone, the Forth Valley Lions Club held the Errol Nothrop Memorial Car Show, with all proceeds from that event also going to Menzies.

Almost 250 cars were on

show, including vintage, hot rods and racing cars, bringing 1100 people through the gates and raising around $6500 for Menzies.

A big thank you to the Rotary Club of Moonah, the Forth Valley Lions, to all those who volunteered at the events and all who attended.

Thank You Day During September and October Menzies held Thank You Day events to so we could meet and acknowledge our wonderful supporters from throughout Tasmania. We hosted more than 220 guests across the three events – in Hobart, Launceston and Burnie. Our supporters contribute in a variety of ways –

Menzies researchers invited adults from rural areas across three Australian States to speak up about whether the design of their local area helps to get them moving. In response, 447 people from Tasmania, Victoria and South Australia completed the survey.

Keep up with our news

Among the findings, about half of participants (51%) did not have a bus or train stop within walking distance, and 56% indicated that walkways were not well maintained. Pubs and supermarkets were more likely to be within easy walking distance than schools or workplaces.

Dr Verity Cleland, a physical activity researcher from

Below: The Ulverstone Showground was a sea of cars for the Errol Nothrop Memorial Car Show

funding research projects, providing student scholarships, donating to researcher salaries and equipment and volunteering on administrative and research work at the Institute.

We couldn’t do it without you!

Menzies Director, Professor Alison Venn, left, with her Excellency the Honourable Professor Kate Warner, Governor of Tasmania, and Menzies Deputy Director, Associate Professor Tracey Dickson, at the event in Hobart

Clues to what gets us outside and active You might recall our Snakes, Streetlights and Swimming Pools survey from one year ago. The aim of this project was to gather data on whether this kind of infrastructure has an influence on healthy lifestyles in rural areas.

Above: Professor Mark Nelson, from Menzies, accepting a cheque from the organisers of the Festival of Wheels.

Menzies who led the study, said further work will aim to understand which features of this environment hinder or support physical activity, and what we can do to create environments that support active living.

The study team included researchers from the Institute for Physical Activity and Nutrition at Deakin University in Victoria and

Snakes, streetlights & swimming pools survey summary: menzies.utas.edu.au/snakes_streetlights_swimmingpools Parkrun survey summary: menzies.utas.edu.au/parkrun For more information on participating in parkrun: parkrun.com.au

the University of South Australia.

Dr Cleland has also been investigating the popularity of the parkrun movement, which provides free weekly 5km walk/run events in 14 countries around the world.

“Parkrun shows great promise as a setting for physical activity promotion,” Dr Cleland said. “It engages people who are less likely to participate in physical activity and it can make a significant contribution to the weekly recommended physical activity target.”

In Tasmania, parkrun events are held in Hobart, Devonport, Railton, George Town and at two locations in Launceston.

Would you like to keep up to date with the latest Menzies news? Find us on Facebook and ‘Like’ our page. You can read all of our Bulletins and reports electronically at issuu.com.

Menzies Bulletin Summer 2017 5

out and about

Conference a huge success Menzies computational genomics researcher Dr Jac Charlesworth, who is an Executive Member of the Australasian Genomic Technologies Association, convened the organisation’s national conference in Hobart from October 29 to Nov 1.

The program was packed, with 174 registrants, four international speakers, 12 sponsors, 27 exhibitors, two pre-conference workshops and 45 oral presentations. The conference was supported

by Menzies and a number of

Menzies staff and students attended and presented.

Menzies Deputy Director Associate Professor Tracey Dickson and her lab group joined about 200 others in the Walk to D’feet MND at the end of October at the Domain Athletics Centre. Associate Professor Dickson gave a short talk about Menzies and our MND research at the event.

Tasmanian Devil researcher Dr Andy Flies and his wife Emily are the masterminds behind

Dr Jac Charlesworth (second from left) with fellow executive members Ruby Lin, Nicole Cloonan and Alicia Oshlack at the conference in Hobart.

Hobart’s highly successful Science in the Pub. These themed events, held regularly at the Republic Bar and Café in North Hobart, are an informative and engaging way to interact with science. We encourage you

to take a peek at their Facebook page (Facebook.com/ scienceinthepubtasmania/) and then spread the word.

Their next event, Earth’s everchanging climate, will be held on February 1.

KAROAKE: A randomised trial of krill oil for osteoarthritis of the knee to examine use of krill oil to improve knee pain and slow down progression of knee osteoarthritis. Participants must be aged 40 years or more; have significant knee pain and swelling most days for at least six months; able to have a knee MRI. Contact: Carole.Goff@utas. edu.au or (03) 6226-7648

severe vision loss treated by an ophthalmologist). Contact: maria.cooper@dhhs.tas.gov.au or (03) 62264731

STUDIES RECRUITING PARTICIPANTS The Tasmanian Chronic Kidney Disease Study is seeking people over 18 years of age who have severe chronic kidney disease (eGFR less than 30mls/min/1.73m2) AND who are not receiving dialysis or a kidney transplant.

Participation requires an appointment for one to two hours. Contact: Hannah.

RobertTissot@utas.edu.au or (03) 6226 7700.

QUARTET: A trial to assess the effectiveness and tolerability of ultra-low-dose quadruple combination therapy (‘LDQT’) in patients with hypertension. Contact: Kirby.

Donaldson@utas.edu.au or (03) 6226-4767.

The Menzies Blood Pressure Clinic is a community service offered to help improve the care of people with problems related to high blood pressure. The clinic uses the latest methods dedicated to the investigation and management of high blood pressure. People referred to the clinic undergo various blood pressure tests, as well as comprehensive risk assessments. A report is then

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Menzies Bulletin Summer 2017

sent to the referring GP detailing blood pressure measures together with a suggested treatment regimen. All services are bulk-billed. Contact: (03) 6226-4710 or menzies.

BPClinic@utas.edu.au PPMS: Primary Progressive MS Study into risk factors for the onset and rate of progression of Primary Progressive MS. Contact: Susan Dobson (03) 6226-4269 or ppms.study@utas.edu.au, or menzies.utas.edu.au/PPMS AMSLS: The Australian MS Longitudinal Study to provide data of practical use for improving the lives of Australians living with MS. Contact: Kirsty Hawkes (03) 6226-4739 or AMSLS.Info@utas.edu.au, or msra.org.au/AMSLS The OMM Study: developing a questionnaire for mindfulness research.

Participants will have either already done, or be signed up to do a mindfulness course.

More information: menzies. utas.edu.au/omm. Contact: mindfulness.study@utas.edu.au or (03) 6226 4723

AirRater is recruiting people in Tasmania and the Australian Capital Territory with asthma, hay fever or other lung conditions, or carers of those with these conditions.

Contact: 1800 322 102 or air.rater@utas.edu.au

INVEST: INvestigating obEsity Surgery in Tasmania.

Participants need to have been referred to a surgeon for weight loss surgery.

Contact: Dr Michelle Kilpatrick, obesitysurgery.study@utas.edu. au or 03 6226-4630.

STAREE: STAtins in Reducing Events in the Elderly investigating whether a statin can prolong good health and maintain independence among people aged 70 years and older.

Contact: staree@monash.edu or 1800 770 664

Genetics of Eye Diseases for genetic studies in diabetic retinopathy (Participants should have Type 2 Diabetes treated with medication for at least 5 years, or Type 1 Diabetes); keratconus (participants should have keratoconus diagnosed by an optometrist or ophthalmologist); and advanced glaucoma (participants should have any type of glaucoma with

Caught-CAD: Reducing Risk of Coronary Artery Disease in Families is looking for people who are between 40-70 years of age; have a close family member (parent, brother or sister) who has had a heart attack, stent or surgery under the age of 60, and are not currently taking a statin.

Contact: Kristyn Whitmore (03) 6226-4235 or Menzies.

CAUGHT@utas.edu.au

I would like to make a one-off donation of $ I would like to have monthly donations of $ deducted from my credit card I would like to donate to the most recent appeal I would like to update my contact details Note: All donations over $2 are tax-deductible Please accept my donation/s in the form of Cash Cheque/Money Order (Payable to the Menzies Institute for Medical Research) Or, please debit my

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Name on card Signature I /We wish that my/our donation be used for research purposes at the discretion of the Menzies Institute for Medical Research, unless a particular research purpose is stated as follows:

lease do not publish my name in the ‘Valued P Supporters’ section of Menzies’ next Bulletin lease send me information on remembering P Menzies in my Will lease add me to the Menzies mailing list using the P contact details below.

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Please post to Menzies Institute for Medical Research University of Tasmania Reply Paid 77465 Hobart TAS 7000

In Memoriam late-September to mid-November

One sentence in your Will can fund life-saving medical research.

If you would like more information, please contact the Institute Advancement Manager on 03 6226 4236.

Bequests save lives by funding research.

Thank you.

We gratefully acknowledge gifts made from the following estates: Estate of the late Nathalie Phoebe Little We gratefully acknowledge gifts made in honour of: Mr David Barker Mr Benjamin Clark Dr Paul A Cossum Mr Vivian Crocker Mr Bruce Davies Mrs Andree ‘Onny’ Greenwood Mr Peter G Hall Mr Jans Howe Mrs Kathleen O’Dea Mrs Vaninka R Riseley Mrs Mary Venn Mrs Dianne Wyatt