Menzies Summer Bulletin 2018

Bulletin #0095

SUMMER 2018

Ready to launch: innovative multiple sclerosis online course

For further information or to register your interest in participating in the pilot, please visit https://ms.mooc. utas.edu.au/

It’s vital to ensure that the knowledge being shared is evidence-based and has a positive impact

Peter Mathew

In our increasingly online world, the internet is an important tool to help people tackle health problems, spread information, and create communities.

However, it’s vital to ensure that the knowledge being shared is evidence-based and has a positive impact.

The Menzies Multiple Sclerosis (MS) Flagship Program has joined forces with the Wicking Dementia Research and Education Centre and MS Limited to create a world-first MOOC (Massive Open Online Course) to help educate the community about MS. Wicking has an awardwinning Understanding Dementia MOOC, which has seen 155,000 people from more than 180 countries enrol since 2013. The Centre is now working closely with

Global leader: Multiple sclerosis PhD student Renee Pepper with an important MS message.

Menzies to help establish our Understanding MS course. The MOOC has been designed for people living with MS, their carers, support networks and health care providers to inform people with accurate and up to date information about the disease. Information on risks, symptom management,

interventions and lived experience are given through a series of video interviews which include people living with MS, academics, nurses, and allied health professionals.

A short assessment at the end of each chapter allows participants to track what they have learned along the way.

You can help make a difference in prostate cancer This year our Summer Appeal focuses on raising funds for research into better screening and treatment for prostate cancer.

In Australia, prostate cancer is the most commonly diagnosed cancer in men.

In 2018, it is estimated that more than 17,500 new cases of prostate cancer will have been diagnosed. In Tasmania,

around 500 men are diagnosed with prostate cancer and about 100 men will die per year from prostate cancer related complications. The detection and treatment of prostate cancer can be complex in

terms of identifying men at risk, deciding who needs to be treated and determining which treatment will work best for individuals. Current methods are problematic as HOW TO DONATE

The MOOC project team has been working extensively with people living with MS and experts in their field around the country who have generously given their time. The pilot course will begin in January and the first public course is expected to begin in the first half of 2019.

they are based on a “one size fits all” approach. We have the opportunity to make a significant impact on the lives of people living with and at risk of developing prostate cancer.

Please consider making a gift to support this vital research.

Go to the Donate tab at menzies.utas.edu.au, or return the donation slip attached to this Bulletin.

You can also call 1800 638 124 or 03 6226 7700.

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Director’s message Welcome to the Summer Bulletin for 2018 Another year is almost over, prompting me to reflect on our achievements and challenges at Menzies in 2018.

The growth, with collaborators, of our Multiple Sclerosis Flagship Program of research has been inspiring

The growth, with collaborators, of our Multiple Sclerosis Flagship Program of research has been inspiring. In another area, the culmination of many years of research into the effects of daily aspirin for the elderly was a milestone for all involved – research participants, researchers, GPs and medical staff – including our own Professor Mark Nelson (see page 6). Once again this year we have taken our research into the community, invited the community into our building to take part in and learn about our research, and pushed ahead with a multitude of research projects covering cardiovascular disease,

cancer, multiple sclerosis, neurodegenerative diseases, osteoarthritis and eye disease.

In November, I attended the annual Association of Australian Medical Research Institutes convention and dinner and reflected on many discussions relevant to our future at Menzies – what can we achieve in the next 25 years? What are the sustainable funding models for medical research into the future? How do we best use medical research to change health policy and practice? Big and important questions. While there at Parliament House I was delighted to see the awarding of the 2018 CSL Florey Next Generation Award, Australia’s

premier prize for a PhD student in the health/medical sciences.

From close to 90 applicants, Dean Picone from Menzies was placed in the top three for this award (see page 3). This gave me great pride in Dean’s achievements but also in the value that Menzies places on training the medical researchers of tomorrow, who will inherit the challenges outlined above.

On that forward-thinking note, from all at Menzies I wish you a happy and restful holiday season with your loved ones and look forward to another great year in 2019.

Regards,

Professor Alison Venn Director

30-YEAR DECLINE IN CHILDREN’S MUSCULAR FITNESS New research has found a dramatic decline over the past 30 years in the muscular fitness of Australian 11- and 12-year-olds.

Researchers from Menzies, the Murdoch Children’s Research Institute in Melbourne and the University of South Australia looked at the distance 11- and12-year-old children could long jump from a standing start.

They compared data from 1,765 children in 2015 with data from 1,967 children in 1985 and found that the children

These findings add another element to the knowledge we are building 2

Menzies Bulletin Summer 2018

surveyed in 1985 could, on average, jump 11.1cm further, even allowing for the fact that children were smaller then.

The lead author of the study, PhD student Brooklyn Fraser, said the findings showed that despite the health benefits of muscular fitness becoming increasingly recognised, childhood muscular fitness levels were declining.

These findings highlight the importance of efforts to promote childhood muscular fitness and encourage children to meet physical activity guidelines.

She said the findings were reinforced by recent updates to physical activity guidelines, which now incorporate muscle strengthening activities for children.

The report’s co-senior author, Dr Costan Magnussen, said that the role of muscular fitness

as a cardiovascular risk factor was an important emerging area of research.

“These findings add another element to the knowledge we are building on how childhood health impacts on cardiovascular health in adulthood,” he said.

Menzies 5km Walk

We will be off and walking again on Sunday, February 17 for the Menzies 5km Walk, which is part of the 2019 Bank of us Run The Bridge Hobart.

There are two great reasons to get behind the Menzies 5km Walk – you will be doing your physical and mental health a favour and the Bank of us Run The Bridge organisers will donate part of your entry fee to medical research right here.

See you on the Bridge! Enter now at www.hobartrunthebridge.com.au

AWARDS

Young scientist award for arthritis researcher Menzies arthritis researcher Dr Dawn Aitken has topped off a hugely successful year by being named the Tasmanian Young STEM Researcher of the Year.

Dr Aitken applied for and was offered three competitive mid-career fellowships in the 2017-18 financial year, including a four-year NHMRC/Medical Research Future Fund Career Development Fellowship.

She was also awarded her first NHMRC Project Grant as Chief Investigator. Through this $1,309,503 grant Dr Aitken is leading a multi-centre randomised controlled trial evaluating an anti-inflammatory drug (that is not currently approved in Australia) to treat knee osteoarthritis.

Dr Aitken had 13 papers accepted or published in the 2017-18 financial year, including

a lead-author paper that was the first study to trial a particular rheumatoid arthritis drug for hand osteoarthritis.

She was awarded the 2018 American Society for Bone and Mineral Research Rising Star Award, and the 2018 Australian and New Zealand Bone and Mineral Society Award for the five best papers published in the past five years in the field of

What I’m really looking forward to now is consolidating the work I have under way

Vice-Chancellor Awards – 2018 Winners Menzies is proud to have two staff honoured this year in the University of Tasmania ViceChancellor’s Awards.

Dr Carlie Cullen, who is researching the use of noninvasive magnetic stimulation to promote brain repair in multiple sclerosis, received the award for Outstanding Research Performance by an Early Career Researcher. Dr Cullen is pictured with the Vice-Chancellor of the University of Tasmania,

Professor Rufus Black. The Award for Outstanding Community Engagement went to the Science in the Pub team, which includes Dr Andy Flies and Dr Emily Flies (pictured). Andy is a researcher in the Tasmanian Devil Facial Tumour Disease vaccine research team at Menzies. Professor Black said it was important to recognise, deeply value and acknowledge the achievements and outstanding contributions of the recipients of the awards.

Honoured: Menzies arthritis researcher Dr Dawn Aitken.

bone and mineral research.

Dr Aitken also led the development of new collaborations between Menzies, the Tasmanian Health Service and the Royal Hobart Hospital to improve the way osteoarthritis and other musculoskeletal conditions are managed in Tasmania.

“This is very generous recognition and I feel really fortunate to be given this honour on top of what has

Blood pressure research Shortlisted for prestigious prize Menzies blood pressure researcher Dean Picone was one of three finalists in the 2018 CSL Florey Next Generation Award.

The award, bestowed biennially, is for Australia’s most promising up-and-coming medical researcher. It is offered to PhD candidates who have demonstrated outstanding capability, creativity and potential in the biomedical sciences and/or health and medical research.

already been a wonderful year for me,” Dr Aitken said. “What I’m really looking forward to now is consolidating the work I have under way, in collaboration with others, in seeking better treatments and prevention for osteoarthritis.

“It’s really important that we stay focused on achieving a better quality of life for people with osteoarthritis, and where possible, on preventing the onset of the disease.”

Dean, who works with Professor James Sharman’s Blood Pressure Research Group at Menzies, is developing a new approach to measuring blood pressure with much higher accuracy and sensitivity than current methods. The ultimate goal of the work is smarter diagnosis and management of high blood pressure that will lead to fewer heart attacks and strokes.

The award was won by Hamish Graham, of the Murdoch Children’s Research Institute.

Hamish’s research focuses on making supplementary oxygen available to every child in Nigeria who needs it, ending unnecessary deaths from treatable conditions such as pneumonia.

Would you prefer to receive our publications and invitations by email? If so, simply let us know by sending an email to enquiries@menzies.utas.edu.au. Alternatively, to update postal details please tick the box on the tear-off slip attached to the Bulletin and return it to us. If you use the Reply Paid address at the bottom of the tear-off slip you won’t need a stamp.

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RESEARCH THANKS TO YOU

Making a difference to mental health

Our chance to say Thank You

In a fantastic boost for mental health research at Menzies, this year’s Tasplan & Emergency Services Charity Ball raised $42,000.

Our annual Menzies Thank You Day on 30th October celebrated all those who have made a contribution this year through gifts, partnerships, participation in studies and volunteering.

Without the generous support of our community we would not be able to achieve our mission of performing internationally significant medical research leading to healthier, longer and better lives for Tasmanians. Every week volunteers contribute to the Institute’s work in

In a beautifully decorated venue (right), Menzies mental health researcher Dr Fiona Cocker (featured on page 5 in our Researcher Profile) spoke to the 475 guests about her research, focusing on workplace mental health, preventing mental illness, and quantifying and reducing the cost of mental illness in health and economic terms.

Forty-five per cent of Australians have experienced a mental disorder in their lifetime, with an estimated 20 per cent of the population experiencing a common mental disorder in the past 12 months.

In Tasmania, approximately 15,000 Tasmanians are living with severe mental illness, almost 30,000 people have reported a moderate mental illness and almost 60,000 a mild mental illness.

…15,000 Tasmanians are living with severe mental illness…

The funds raised by the ball will contribute to research into better understanding the mental health of Tasmanians, particularly in relation to post traumatic stress disorder.

many different ways.

Every donation and bequest received by Menzies, irrespective of its size, goes towards directly to medical research in Tasmania.

This year we anticipate that philanthropic support will have grown to around $3.5 million.

In 2018 we have offered 32 PhD and Honours scholarships and six research fellowships enabled by the generosity of individuals and organisations.

To all those who contribute to Menzies, we thank you.

THANK YOU TO ALL OF OUR DONORS FOR YOUR ONGOING FINANCIAL SUPPORT AND COMMITMENT TO MENZIES Listed below are our Everyday Angels – our supporters who make regular gifts to Menzies.

Mr Timothy Albion Ms Juliet Allen Ms Anita Allie Ms Kylie Anderson Mrs Teisha & Mr Aaron Archer Mrs Jennifer & Mr Lionel Banks Ms Jess Bannister Mrs Jan Barren Mrs Larissa & Mr David Bartlett Ms Janet Beadle Mrs Kathleen Bevis Mrs Pamela Blunt Ms Jess Bradley Ms Kathleen Brient Ms Beverley Brown Mrs Jane Burrell & Mr Lloyd Sokvitne Ms Jill M Cassidy Dr Susan R Cherry Mrs Emma & Mr Timothy Claridge Mrs Anita & Mr Michael Clarkson Mr Peter Cochrane & Ms Miranda Harman

Mr A M Cornish AO Mr Robert & Mrs Gloria Cotgrove Mrs Diane & Mr Jonothan Davis Ms Moya T Deigan Ms Carolyn Dunnewijk Mrs Patricia & Mr Donald Edwards Mr Josh & Mrs Felicity Ey Mrs Elaine & Mr Dennis Fairfield Dr Derek & Mrs Elizabeth Findlay Mr Peter Fountain Mrs Beverley Geard Mr Don W Goff Mrs Judy & Mr Trevor Grant Mr Garth & Mrs Brenda Haas Mrs Susan Haigh Mr Philip Hand Ms Judith Hastie Mrs Shirley & Mr Frederick Heath

Ms Judy Hebblethwaite Ms Alison Hennessy Mrs Susan L Hinds Ms Di Hodel Mr B & Mrs J Hortle Mr Andrew C Hudson Mr John W Hudson Ms Shelley Hunter Ms Carol Hurst Mr Darrin Irvine Mr Gary & Mrs Susan Jacobson Mrs Wendy Jefferies Mr Raymond & Ms Dianne Jones Ms Dianne & Mr Raymond Jones Mrs Margaret & Mr Alan Keogh Ms Margaret Knight Ms Sabina Lane Mrs Terry & Mr Ian Law Ms Anne & Mr Anthony Le Clerc Ms Rebecca Lipscombe

The following individual and community supporters donated for the first time between early August and early November.

ADG Laboratories Mr Ashley How Tasmania Mrs Veryan Bradshaw Ms Tamryn Long Thursday Tai Chi Mr K & Mrs J Chipman Mr Michael Mitchell Group Mrs Lou-anne P Folder Dr H & Dr R Nogajski Miss Frances R L Mr Ross D Gilligan Property Inspections Xiberras

Mrs Jane & Mr Nicholas Lovibond Mr David T MacLeod Mrs Marie Magill Mrs Betty M Marshall Mr Dugald McDougall Mr Marcus McEwan Mrs Helen McKibben Mrs Frances Joan McKinlay Ms Kate McQuaid Mrs Philippa Micklem Mr Sam Mollard Mr Peter Morgan Ms Wendy Noye Mrs Anita Nutting Mrs Astrid A O’Toole Mrs Sally Oakley Mrs Jennifer A Parsons

Miss Alison Parsons Kim Paterson Mrs Glenda Paton Mr Andrew J Pitt Mr Nathan & Mrs Christabel Porter Mrs Pamela Rabbidge Ms Jillian Reade Mr Alan & Mrs Jancis Rees Mrs Margaret & Mr Brian Richardson Mrs Jill & Mr Eric Robinson Mrs Frances M Russon Mrs June Scott Mrs Susan Sluce Mr Richard Sperring Mr Alex Stanelos Miss Amber C Sturges

Ms Carmel Taylor Mrs Cynthia Tennant Mrs Brenda Triffitt Ms Karen Twynam-Perkins Mrs Rosemary Van den Berk Mr Walter & Mrs Robin Verth Mrs Anne Warren Mr Peter Weldon Ms Caroline Wells Mr John & Mrs Kathlyn Wheatley Mrs Kathryn Whitchurch Ms Barbara White Ms Mandy J Williams Ms Janice Wilson Mrs Elizabeth Woolley

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RESEARCH HIGHLIGHTS

RESEARCHER PROFILE

Dr Fiona Cocker

Post-doctoral Research Fellow You have rejoined the Menzies staff relatively recently ... What were you doing before this?

I completed my PhD at Menzies in 2013 and then spent nearly four years in Melbourne working at the University of Melbourne’s School of Population and Global Health and then Monash University’s Centre for Occupational and Environmental Health. I returned “home” to Hobart, and Menzies, last year.

What is the focus of your research?

My research focuses on the role employment plays in mental and physical health and wellbeing, and how employers and workplaces can improve the health of the working population. I have a

We need action to push for reform, fight stigma and campaign for change

particular interest in the mental health of the medical and first responder workforces and the people who support them.

What are some of the recent findings from your work?

My study comparing the costs and health outcomes of taking sick leave versus working when experiencing depression found that continuing to work can be beneficial for employees with mildmoderate depression due to maintaining routine, sense of purpose and social connectivity and support. Another study I completed found that among employed Australians, 5.8 per cent ($890 million) of the annual societal

Health impacts of air pollution go well beyond our airways The association between poor air quality and heart and lung diseases is well known, but a recent study led by Menzies has also shown links with diabetes.

The research looked at the medical reasons behind almost 400,000 ambulance call-outs in Tasmania, Victoria and NSW and their links to air quality.

The study found that increases in air pollution particles of less than 2.5 micrometres in size (a micrometre is one-thousandth of a millimetre) were associated with an increased risk of ambulance call-outs for low blood glucose levels, irregular heartbeats, heart failure, fainting, asthma, chronic obstructive pulmonary disease and croup. The association with call-outs for low blood glucose in people with diabetes was a consistent finding across all states.

“Air quality is commonly, but

erroneously, thought of as a respiratory issue. That is, affecting mainly our airways,” said the lead researcher, Associate Professor Fay Johnston. “But the findings in this study support the strong evidence that worsening air quality can lead to cardiovascular conditions, and the emerging evidence of its links with diabetes.

“Air pollution is known to promote inflammation and be linked with higher blood glucose, but this is the first report of a possible association with low blood glucose” Associate Professor Johnston said the way in which air pollution and diabetes were linked was still unknown and researchers were keen to explore this association further.

The study was also novel in that, by using ambulance rather than hospital data, it opened up ways of unlocking answers on how air pollution negatively affects health.

cost of depression was attributable to job strain through a combination of high job demands and low control. Employers bear these costs through productivity loss and increased risk of job turnover among employees experiencing depression. These findings demonstrate likely financial benefits to employers who implement workplace programs to reduce risk factors that contribute to poor mental health, such as job strain.

What is the biggest challenge in your area of research?

In recent years, awareness of mental illness has advanced significantly. But we also need action to

push for reform, fight stigma and campaign for change. So, the next steps for mental health research need to be about improving access to good quality programs and services, ending stigma and discrimination, and increasing support for carers and families of people experiencing mental illness.

What do you do in your spare time?

I’m enjoying being back in Hobart and experiencing all the great new eateries and watering holes that have opened in the years I was away.

I love to bake and the more challenging and complicated the recipe the better. It’s a stressrelieving activity with a delicious by-product.

A VERY MENZIES CHRISTMAS In need of last-minute Christmas cards?

$10

PACKS OF 12 CARDS

Don’t forget that you can get beautiful Menzies Christmas and greeting cards by Tasmanian artists now and throughout the year.

All proceeds go directly to medical research at Menzies.

How to order: Online: www.menzies.utas.edu.au/cards

In person: visit the reception desk at the University of Tasmanian Medical Science Precinct, 17 Liverpool St, Hobart, during office hours. Our Christmas cards are also on sale at the Charity Christmas Card Shop at St David’s Cathedral, 23 Murray St, Hobart.

Over the phone: 03 6226 7700 Thanks to our generous artists and our print and design partners – Winc, Mercury Walch and The20 – all proceeds from the sale of these Tasmanian art cards go directly to support research at Menzies.

Key appointment for Director The Menzies Director, Professor Alison Venn, has been appointed to the advisory council for the nation’s top medical research funding organisation. Professor Venn is an internationally renowned population health expert with broad experience in chronic disease. She said she considered it a “great privilege’’ to be appointed to the 15-member advisory council of the National Health and Medical Research Council.

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RESEARCH THANKS TO YOU

Research answers aspirin question It’s been the subject of debate in medical circles for many years – could a daily dose of aspirin prolong good health in the elderly? Until now there has been speculation but no thorough peer-reviewed research results on whether aspirin plays a role in longevity and good health in old age. The international ASPREE (ASPirin in Reducing Events in the Elderly) study set out to find the answers, and this research will now guide GPs in how they prescribe aspirin to the elderly.

Professor Mark Nelson is a Hobart GP and one of the Chief Investigators on the ASPREE study: It has been a great pleasure to work on the ASPREE study, which started for me as a National Health and Medical Research Council (NHMRC) post doctoral clinical fellowship awarded in 2002. Since then it has grown to involve more than 19,000 participants and 2,000 Australian general practitioners. Tasmania was a significant contributor to this research, with more than 2,000 participants from the community, hundreds of GPs from Smithton

to Cockle Creek and a dedicated group of staff working out of Burnie, Launceston and Hobart.

Such public-good research relies on the generosity of our participants, GPs and general practice staff as well as the funders, in this case the National Institute of Aging, the NHMRC and industry (Bayer supplied us with aspirin and placebo but was not involved with running the study).

The drug we studied, aspirin, has been around for over 100 years and is known to protect people who have had a heart attack or stroke. However, it is

Healthy older people who have been regularly using aspirin should consult their doctor, who can provide individualised advice based on risks for cardiovascular and other diseases, as well as other factors.

also known to cause bleeding.

It may also work to prevent cancer and other diseases prevalent in the aged. We wanted to know if it worked in older persons (who are often neglected in clinical trials but end up on the drugs!) and was safe.

So, what did we find? Well, to best answer the question we looked at whether aspirin extended healthy active life.

It did not. We did find an expected excess of bleeding in those taking aspirin. Surprisingly, it also showed that those taking aspirin were more likely to die and that this was mainly of cancer. All of these findings mean that we would not recommend aspirin to be taken routinely in those over 70 years who have not had a heart attack or stroke. Indeed, it may be causing harm.

participants aged 40 years or more who have significant knee pain and swelling on most days, are able to have a knee MRI, and have access to email and web browsing.

Contact: Gudrun.Wells@utas. edu.au or (03) 6226 4369.

Alice Saul (03) 6226-4269 or ppms.study@utas.edu.au or www.menzies.utas.edu.au/ PPMS

STUDIES RECRUITING PARTICIPANTS

Standing Tall – Cognition and Gait: Randomised control trial involving six-month home exercise program seeking people 60 years and over who have noticed decline in memory or thinking or have been diagnosed by a health professional with mild cognitive impairment. Must live within 50km of Hobart and not have Parkinson’s disease, multiple sclerosis or dementia. Contact: Standing.Tall@menzies.utas. edu.au or phone (03) 6226 7766 and please leave contact details.

The WALK study is seeking people aged 45 and over who are currently suffering from knee pain. We are looking for people who are not currently very active, but

interested in taking part in a free supervised walking program (twice per week for six months).

Contact: Kate Probert on (03) 6226 7746 or katherine. probert@utas.edu.au.

METHODS: This randomised controlled trial of methotrexate is seeking participants aged 40-70 years with moderate to severe hand joint pain.

The study aims to reduce pain and swelling and slow joint damage in people with symptomatic hand osteoarthritis and synovitis. Contact: Kathy Buttigieg on (03) 6226 6909 or Kathy.Buttigieg@utas.edu.au.

CurKOA trial: A randomised trial of turmeric (Curcuma Longa) for treating symptoms and effusion-synovitis of knee osteoarthritis is seeking

QUARTET: An investigator initiated and conducted, multicentre, randomised double blind controlled trial to assess the effectiveness and tolerability of ultra-low-dose quadruple combination therapy (‘LDQT’) in patients with hypertension.

Contact: helen.steane@utas. edu.au or (03) 6226-4803.

PPMS: Primary Progressive MS Study into risk factors for the onset and rate of progression of Primary Progressive MS. Contact:

AMSLS: The Australian MS Longitudinal Study to provide data of practical use for improving the lives of Australians living with MS. Contact: Kirsty Hawkes (03) 6226 4739 or AMSLS.Info@utas.edu.au, www.msra.org.au/AMSLS STAREE: STAtins in Reducing Events in the Elderly investigating whether a statin can prolong good health and maintain independence among people aged 70 years and older. Contact: staree@ monash.edu or 1800 770 664

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Please post to Menzies Institute for Medical Research University of Tasmania Reply Paid 77465 Hobart TAS 7000

More than flowers In Memoriam

One sentence in your Will can fund life-saving medical research.

If you would like more information, please contact the Institute Advancement Manager on 03 6226 4236.

Bequests save lives by funding research.

Thank you.

We gratefully acknowledge gifts made from the following estates: Estate of the late Marlene Fielding Estate of the late Beryl Kitty Bates We gratefully acknowledge gifts made in honour of: Dr Freda Cook Mr Neil (Mick) A Cupit Mrs Merlene F Fielding Mrs Susan M Gilligan Mr Geoffrey C Glanville Mrs Coralie Glover Mr Leigh T Holdsworth Mr Thomas M Magill Mr James H Martin Mrs Pat McCarthy Mr Robert Bruce Miller Mrs Kitty V O’Boyle Dr Antonia A Ross Mrs Gwynneth Sperring Mr Ted Swinton Mr Dudley J Webberley Mrs Marjorie J Wilson