Aromasin vs Arimidex

AROMASIN VS ARIMIDEX

WHAT EXACTLY IS AROMASIN? Aromasin is the brand name/trade name of a pharmaceutical product manufactured by Pfizer.

Aromasin's main active ingredient is exemestane, also known as EXE, which is a new generation of FDA-approved legal steroidal selective irreversible aromatase inhibitor.

WHAT EXACTLY IS ARIMIDEX? Arimidex is the brand name/trade name of an AstraZeneca pharmaceutical product. The main active ingredient in Arimidex is anastrozole, which is a new generation of FDA-approved nonsteroidal selective reversible aromatase inhibitor.

MAIN DIFFERENCES: AROMASIN VS ARIMIDEX (I). Class: Type I inhibitors - Steroidal (Aromasin) vs Type II inhibitors NonSteroidal (Arimidex) Aromatase inhibitors are classified based on their relative potency. In vivo studies define potency as the ability to suppress both circulating estrogen levels and aromatase activity. They both interact differently with the aromatase inhibition process.

(II). Aromatase interactions Type II AIs (Arimidex) form a noncovalent bond with estrogen in order to bind its site and prevent/minimize binding activity with androgens. Because of its noncovalent interactions, the weak bond formed does not share electrons. As a result, this aromatase process is thought to be reversible and thus easily displaced by another substrate during the equilibrium reaction.

On the other hand, Type I AIs (Aromasin) is structurally related to androstenedione compounds, which are the natural aromatase substrate to the active site of the enzyme interaction and halt activities. Exemestane is converted during the process to an intermediate that forms covalent bonds with the estrogen corresponding site. This covalent reaction is irreversible, and the bonding is much stronger than a non-covalent bond.

As a result of its ability to have a powerfully irreversible reaction during the equilibrium aromatase reaction, Aromasin is also known as a suicide inhibitor.

You can learn more about the strength of different chemical molecular bonding types by clicking here.

(III). Side effect: Aromasin vs Arimidex The most common and serious side effect of any type of aromatase inhibitor is bone mineral density (BMD) loss, also known as poor bone strength (osteoporosis) in more severe cases.

When estrogen levels are too low, bone mineral density suffers, and fractures may occur if aromatase inhibitors are taken on a long-term basis.

According to a study published in The Lancet Oncology [3], aromasin (25 mg daily) has a less negative effect on bone mineral density loss than arimidex (1 mg daily) after comparing changes in BMD in the lumbar spine and total hip areas among treated women.

How to avoid

Aromagin, a PCT product designed and manufactured by Mega Muscles, is complexed by a powerful antioxidant compound called "L-cysteine derivative." According to one study [4,] it has a suppressive effect on overall bone mineral loss caused by a decrease in endogenous estrogen levels.

As a result, using Aromagin as estrogen blocker/anti estrogen/aromatase inhibitor supplements can provide the aforementioned benefits over other products. In our bodybuilding progress, it can reduce the risk of BMD loss while providing organ support and stronger aromatase inhibiting effects than arimidex.

DOSAGE ON CYCLE OR DURING PCT OR FOR GYNO The dosage of both AIs on cycle and during pct is discussed in the following sections and supported by clinical studies.

Aromasin At 25 mg daily, the results of a clinical study were promising. The graph below depicts different averaged hormone concentrations after 25 mg and 50 mg daily on 12 young males on day 10. In the separate table at the site of reference source, the percentage change of free testosterone was also greater than 100 percent.