LAXOGENIN

LAXOGENIN

WHAT IS LAXOGENIN? It is different from 5-alpha-hydroxy-laxogenin, which is the derivative of laxogenin. When users search for it, they are simply looking for the muscle supplement compound "5-alpha-hydroxylaxogenin".

It has multiple synonyms, they are: 

Spirostan-6-one Biobras-16 Brassinosteroid BB-16 Brassinosteroid DI-31

  

The molecular formula is: CHO 27

42

5

Formula weight Is: 446.6 g/mol Purity (in Laxogin): ≥98.5% Phase formulation in Laxogin: Liquid Storage:

Room temperature Description: It is a diosgenin derivative and brassinosterod analog. It has the ability to inhibit sodium chloride for preventing the salt stress from ethylene production and polyamide synthesis in the plant lettuce.

Usage in agriculture: It has been shown to have several bioregulating functions and to promote various growth and development process in the living cells. For example:    

Simulating cell elongation and division in plant growth promotion Increasing biomass productivity and crop yield Compensating the stress effect induced by salt stress and winter Ethylene biosynthesis enhancement

Origin: Steroid From Plants

A compound marketed in different forms as a muscle developing supplement is Laxogenin (3beta-hydroxy-25D,5alpha-spirostan-6-one). It belongs to a class of high quality plant hormones known as brassinosteroids with a structure similar to the animal steroids. They help increase growth in plants.

The Smilax seboldii underground stem contains about 0.06% laxogenine and is its primary natural source. Laxogenin is also derived from Chinese plant.

The more popular plant steroid, diosgenin, is used to manufacture laxogenin in supplements. In reality, more than 50 percent synthetic steroids such as progesterone, cortisone and testosterone have diosgenin in their raw material.

While often reported to be "natural," most muscle building supplements do not contain the synthetic derivative laxogenin but 5a-hydroxy laxogenin (laxosterone).

An study of 12 different supplements revealed that 5a-hydroxy laxogenin mostly comes from synthetic laxogenin. Relevantly, 5 additional substances had no 5a-hydroxy laxogenin and 8 were infected with diosgenin that was untested.

It is a natural steroid found in various plants, but its synthetic analog, 5a-hydroxy laxogenin and untested contaminations are included in most supplements.

Our Laxogin features more than 98.5% 5a-hydroxy-laxogenin content in high absorption liquid formulation without any unnecessary side substances. The content is certified by our engineer and multiple lab equipment (Nuclear Magnetic Resonance Spectrometer and High-Performance Liquid Chromatography Systems).

USAGE IN CREATURES - LOW BIOAVAILABILITY OF LAXOGENIN (UPDATED ON 04/05/20 21 )

Since it belongs to herbal resourced compounds, it has poor solubility and permeability to the bloodstream. To enhance the bioavailability of such excellent bodybuilding supplement, pills or capsule formulation is not enough. Once pills or capsules pass through the digestive system, the concentration of the supplement will be reduced due to food blockage in the digestive system, the first-pass effect of gastrointestinal tract and liver [2].

To preserve the concentration of 5a-hydroxy laxogenin, sublingual route is always a preferable route over traditional delivery methods [1] because it can bypasses the first-pass effect and therefore facilitates fastest absorption and more dosage of the compounds into the bloodstream.

However, these are disadvantages of sublingual route:

 

Most laxogenin supplement (more than 99%) are not available as sublingual formulation Most users cannot accept the taste of the sublingual dosage

LAXO G IN - A FLAVO RED LIQ UI FI E D CLEANES T 5A H YDRO XY LAXO G ENIN DES IG N ED AND M ANUFAC TURED B Y M EG A M US CLES Laxogin features the excellently flavored and self-emulsifying drug delivery system that contains micronized particles of the compound, which is the only laxogenin liquid supplement on the bodybuilding market that can be taken sublingually with delightful flavor. The micronization of particles in the liquid carrier allows instant diffusion of the compound orally and zero reduction of loss of the dose into the bloodstream. More detail is available below:

Snapshot

Supporters:       

User reviews are mostly positive Users show less side effects than steroids and prohormones Typically stacked with additional supplements Study for cancer, tissue damage and diabetes Increase strength Improve recovery An excellent alternative to testosterone booster

Skeptics:     

No clinical testing and just a few tests of animals and cells Unfinished safety profile & possible unknown side effects Synthetically produced Insufficient proof for medical use Non-test supplements and low quality

PUTATIVE EFFECTS (BE NEFITS OF LAXOGENIN AND HONEST REVIEW) The general advertisement for 5a-hydroxy laxogenin (aka 5-alpha hydroxy laxogenin) is:     

Lean muscle mass building Increase protein synthesis Burn fat stored Improve physical fitness and restoration Improve cortisol

It is not a steroid or prohormone, as opposed to conventional muscle building steroids. The supporter takes this as meaning that the sex hormones (testosterone and dihydrotestosterone) are neither transformed to more effective male nor risk increasing oestrogen.

However, we can't know this because it was never properly tested. Moreover, according to the sport nutrition authorities, the evidence for laxogenin's efficacy is not adequate.

This leaves laxogenin dangling in the grey area: not entirely natural or synthetic, without proof of risk or safety.

It supposedly improves muscle development and fat consumption while not inducing usual steroid side-effects. However, the assertions are not supported by any proof.

Genetics The activation of AKT1 could potentially increase the muscle building. Individuals with mutations in this messenger protein may have a changed laxogenin response.

Help protect yourself and your health from disease and viruses!

Increase your immune system with a genetic approach to your wellbeing, improving your entire body.

Is Laxogenin legal or illegal?

Yes, it is legal and it is the latest dietary supplement.. However, no medical use or health claims of any kind are allowed at the moment. Most users use it for the purpose of bodybuilding and enhancing their workout effectiveness.

Is laxogenin banned?

Obviously not, it is helping bodybuilders/muscle builders grow muscle naturally.

HOW DOES LAXOGENIN WORK It provides many natural anabolic benefits for human cellular tissues and joints due to its similar chemical structure to animal growth hormones. Because of the chemical structure difference between human growth hormone and the compound, it is no longer a prohormone.

Not a Prohormone Laxogenin is sometimes misrepresented as a prohormone.

A prohormone is a material for hormone development, and hence Prohormone, is used as the building block. Androgenic prohormones, which the body transforms into testosterone, are the most common.

However, laxogenin is a plant steroid that is very similar to human sex hormones derived from cholesterol. However, since laxogenin is a special herbal compound, it affects various ways throughout the body.

Human steroid hormones such as testosterone work via nuclear receptors. Plant steroids such as laxosteroids obviously improve plant growth, but their effects are more elusive on humans and animals.

Laxogenin is not a prohormone, despite the widespread misunderstanding. It's like sex hormones, but it works differently.

Mechanism Plant steroids operate in an entirely different way than human steroid hormones. They only bind to the cell surface that sends a signal to create muscles within the cell.

More specifically, they improve muscle building and avoid the disintegration of the muscle proteins by activating a protein kinase B called AKT1 or protein kinase.

In addition, natural derivatives of laxogenin block cAMP breaking up enzymes (phosphodiesterase). This improves cAMP levels, improves fat breakdown and activates the (funny) response to combat or flight.

Laxogenin supports the construction of muscle and the breakdown of fats by activating anabolic protein and the flight response.

Anabolic Effects Laxogenin is sold for athletes and bodybuilders as a muscle toning supplement. Protein production in muscles is said to increase by 200 percent.

In an ancient Russian study in rats, brassinoid derivatives with a similar structure to laxogenin increased the total liver, heart, kidney and leg muscles in weight and proteins without raising or imitating the levels of sex hormones.

Another plant brassinosteroid has been shown to improve the intake of food, weight gain, lean body mass, leg weight and physical health of rats. rats. Both the molecule and its synthetic derivatives in muscle cells facilitated the production of protein and decreased the breakup of protein.

The class of plant chemicals that have similar brassinosteroid structures (phytoecdysteroids) has increased animal muscle growth and muscle cell protein production.

Although they are all the same, they are not the same. Laxogenin (and its derivatives in additives) may have anabolic effects of similar kind. As they have not yet been studied, however, when we talk about the muscles of laxogenin, we are still in the dark.

Overall, there is insufficient evidence for the supposed muscle building properties of laxogenin.

Laxogenin-like compounds encourage animals to produce protein, grow muscles and fitness.

Laxogenin has anabolic effects of this kind, but studies have yet to prove that.