Medtronic_2011

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www.medicalfutures.com

6th June 2011



Anything that makes the quality of a patient’s life better should be pursued. Our problem is that we get obsessed with making money. You have to start somewhere and make something. If you make something which works, it’ll make money. Sir James Black OM (1924-2010) Nobel Laureate Medical Futures Lifetime Achievement Award Winner

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Innovation is the life blood for any organisation and over the coming years of economic uncertainty, there has never been a more pressing demand for healthcare innovation, especially for technologies or therapies that seamlessly integrate into front line service delivery, leading to efficiency gains and enhanced outcomes for patients. The Medical Futures Innovation Awards and its peer review process is one of the world’s leading fora for catalysing medical innovation. We continuously engage with the medical funding bodies, venture capital

organisations and industry to create and mobilise new routes to funding and work with investors and industry to facilitate the progression of ideas to improve patient care.

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The best ideas are now being pitched to our experts. Be one of the first to see the showcase at Europe’s largest exhibition of early staged healthcare innovation on the 6th June in Central London, followed by the Gala Awards ceremony, referred to in the press as the “Oscars of Healthcare”.

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A Medical Futures Innovation Award is the UK’s most sought after healthcare accolade, rewarding ground breaking innovation from frontline clinicians and scientists. Winning an Award significantly enhances one’s chance of clinical and commercial success.

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Each year, thousands of ideas are seen at all stages of development and many, whilst academically sound, lack a market facing or commercial dimension. Indeed many of the more advanced, venture capital backed businesses we see, lack medical insight and the clinical evidence necessary for market penetration.

their aspiration to drive forwards their ideas. A series of workshops called i2 Events, help provide service transformation; legal; and market oriented commercial advice to healthcare innovators. So far, thousands of clinicians, scientists, and entrepreneurs have attended Medical Futures’ events - connections are made, and ideas are brought to life.

Anyone involved in the healthcare sector can enter with ideas at any stage, from concepts through to trading businesses. Throughout the year, a series of activities take place in the background that encourage, support and reward innovators in

The best ideas are then assessed by peer review panels of leading experts. Winning ideas gain critical endorsement and recognition; access a valuable support network; and increase their chances of investment.

Past winners have secured over £80m of funding, and most importantly many have gone onto become successful services or products that are now changing peoples’ lives (see case studies). Winners are invited to showcase their innovation at the Medical Futures Innovator’s Gallery, Europe’s largest showcase of early staged healthcare innovation. They also receive their Award at a very high profile ceremony in the presence of 800 senior and key influencers in healthcare and business. The event is a celebration of the synergy of clinical and commercial success, and is not to be missed.

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One of the unique features of the Medical Futures process is its world class panel of clinical and commercial experts, each keen on lending their support to the innovators of tomorrow. Over 100 clinical experts come together in specialist panels

to judge ideas in numerous medical areas reflecting key areas of health priority. Shortlisted nominees are invited to pitch to the judges in a “Dragon’s Den” style, offering a refreshing and transparent peer review process.

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Dr Jane Barrett

Professor Keith Fox

Professor Sir Bruce Keogh KBE

President, Royal College Radiologists

President, British Cardiovascular Society

NHS Medical Director & Surgeon

Mrs Brenda Billington

Dr Armajit Gill

Baron Lyell of Markyate PC QC

President, Royal College of Ophthalmologists

President, British Dental Association

Former Attorney General

Sir Victor Blank

Professor Ian Gilmore

Professor Adrian Newland CBE

Former Chairman, Lloyds TSB

Past President, Royal College Physicians

President, Royal College Pathologists

Tony Bourne

Baroness Susan Greenfield

Professor Mike Richards CBE

Chief Executive, British Medical Association

Professor of Pharmacology, Oxford

Cancer Lead, Department of Health

Dr Archie Brain

Nicolaus Henke

Michael Sherwood

Inventor of the LMA Airway

Head of Global Health Systems, McKinsey & Company

Chief Executive, Goldman Sachs International

Professor Sally Davies

Professor Sheila Hollins

Sir Peter Simpson

Director R&D, Department of Health

Past President, Royal College of Psychiatrists

Past President, Royal College Anaesthetists

The Rt Hon Lord Darzi of Denham

Professor Dame Janet Husband DBE

Sir Richard Sykes

Chairman of the Institute for Global Health Innovation

Past President, Royal College Radiologists

Former Rector of Imperial College London and Chairman, GlaxoSmithKline.

Professor the Baroness Finlay

Sir Christopher Kelly KCB

Sir Magdi Yacoub

Past President, Royal Society of Medicine

Chairman of Financial Ombudsman Service

Professor of Cardiothoracic Surgery, Imperial College, London.

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The peer review committee consisted of the Medical Director of the NHS, the head of the British Cardiovascular Society, and other distinguished experts in the field. The peer review doesn’t get much better than that. Professor Michael Schneider Head of the National Heart & Lung Institute, Medical Futures Innovation Award Winner

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Sponsors can build on their relationships with clinicians and policy makers, help realise potential, invest in the future and take a share in the delivery of life-changing ideas.

Networking & Reputation Building Developing and building relationships with policy makers, leading innovators and opinion formers in healthcare takes time, is expensive and complex. The Awards offer a unique and neutral environment to build relationships, encourage cross-fertilization of knowledge across industry and geographical boundaries, and offer unparalleled opportunities to network. Corporate Responsibility Association with the Medical Futures Awards profiles your company's corporate responsibility agenda of helping improve healthcare and patients lives. Innovation is about realising potential. With over 1m physicians across Europe, there is a wealth of healthcare intellectual capital looking for a vent and your support will help unlock that potential from the future leaders of healthcare. Sponsoring a process that unlocks talent and creativity - that moves ideas from concept to market - can only cement your position at the forefront of innovation.

Horizon Tracking There is a growing realisation that companies need to do more than invest in their own internal R&D to bring forward the important healthcare innovations of tomorrow. From Penicillin to MRI Scanners and Hip Replacements to Coronary Stents many of the best innovations have come from practitioners, but finding opportunities is difficult and time consuming. The Innovation Awards will expose you to a wealth of novel technologies; years before they might otherwise appear on your radar, many of which can go on to become companies with substantial growth potential. This is also an ideal opportunity for your company to find hidden treasures of best practice and the up and coming innovators and leaders of tomorrow. Broader Visibility Referred to by the press as the “Oscars of Healthcare�, the Medical Futures Awards and the Innovation Gallery attracts over 1,000 senior guests in a neutral forum. They consistently deliver hundreds of positive stories with high visibility across all forms of media, including television, radio and the broadsheets.

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Rewarding and supporting innovation is the only way you are going to progress. The reason that medical treatments have progressed so much in the last century is because of innovation. John Procter Head of Pfizer Healthcare Solutions

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The Cardiovascular section of the Medical Futures Innovation Awards is sponsored by Medtronic and run in association with the British Cardiovascular Society. A call for ideas was sent out to all clinicians and academics across the UK for treatments for unmet needs, or novel diagnostic methods in coronary disease, hypertension, heart failure, peripheral vascular disease and prevention of stroke.

An esteemed Judging panel has been selected and shall meet in March 2011 to select the winners who will then have the opportunity to raise their profile at the Awards ceremony in June. Aside from having a prominent role at the Awards ceremony, Medtronic shall also be hosting an engagement event with physician innovators in the Galway offices in June 2011.

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Case Study (1924-2010) Nobel Laureate Winner of a Medical Futures Lifetime Achievement Award “In developing beta blockers and peptic ulcer drugs, Sir James Black relieved more human suffering than thousands of doctors have done in a lifetime at the bedside.” James Whyte Black was the son of a mining engineer from Cowdenbeath, a small mining village in Fife, Scotland. After reading Medicine at St Andrews he embarked on a career as a physiologist. Black thought out of the box, and had a wealth of ideas of new ways of discovering drugs. In 1964 his ideas yielded a new class of drugs the

“beta-blockers” that have been used to treat high blood pressure, migranes and heart attacks and quickly became the world’s best-selling drug. For most the invention of one blockbuster would be a lifetime’s work. But Sir James then went onto discover the anti-ulcer treatment cimetidine which in the 1970ís also became the biggest selling prescription drug of any kind in the world. Sir James was awarded a Nobel Prize for Medicine in 1988 and was Knighted for services to medical research in 1981, followed by the Order of Merit in 2000. In 2008, in the presence of his wife Professor Rona MacKie and hundreds of colleagues and peers, Sir James was recognised with a Medical Futures Lifetime Achievement Award for changing people’s lives. Sir James sadly passed away on 22 March 2010, aged 85.

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Case Study Diagnostics for the Real World Ltd Winner of a Medical Futures Innovation Award

In the mid 90’s, Dr Helen Lee and colleagues had a collective vision. Their vision was to deliver a new generation of simple and inexpensive, but robust and technically superior diagnostics for infectious diseases, to the places within the world that need them most. At the time they were working in industry but quickly realised that to achieve their vision they had to take a huge risk, by leaving secure jobs and move to the University of Cambridge to establish an academic unit and subsequently a start-Up to carry out technology development.

Fast forward a decade and they are well on their way to achieving their vision. They run a spinout company, Diagnostics for the Real World (DRW) based in the Bay Area on the West Coast of the USA. They employ 30 staff and most importantly have launched real products that are changing peoples’ lives. Amazingly, and without relinquishing control, the founders have raised $50m from organisations such as NIH, WHO, CDC and the Technology Transfer Division of the Wellcome Trust. They have 4 approved products on the market for diseases such as

Chlamydia and Hepatitis B and their business model is shrewd with a two tier pricing system to offer the developing, and middle-low income countries the benefit of their tests essentially at cost and sometimes free, subsidised by a commercial pricing structure in western markets. They won a Medical Futures Award in 2003, when their ideas were at an early stage. “Winning a Medical Futures Award was a tremendous morale boost for us which also gave us the validation we needed that what we were doing was right” said CEO, Dr Lee, whose ten year plan includes growing the business year on year whilst continuing to provide equity to the developing world.

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Case Study Surgeon & Inventor Winner of a Medical Futures Innovation Award Brian Thornes, a surgeon from Ireland developed a novel medical device used in Orthopaedic surgery to address a common problem in the operative treatment of broken ankles. He designed a suture that holds two ends of a bone together replacing a metal screw which normally had to be removed in a second operation or, if left in, frequently would break when the patient started walking again.

The device was licensed to a large medical device company and the first TightRope® device was implanted in Ireland in 2004. Over 100,000 units have been sold and used in more than 60,000 patients to date, grossing multiple millions of revenue and sprouting numerous line extensions of the technology.

The TightRope® has been used on several celebrity athletes including the likes of Welsh International, Gavin Hensen, and Chicago Bears quarterback, Rex Grossman. “I cannot understate the significance Medical Futures has had on my career path.” Said Brian Thornes, “I am grateful to have been one of the earlier recipients of the Awards. The Judges recognising the potential for my Tightrope device, several years before its market success.”

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Case Study Positive Mental Attitude Sports Foundation Winner of a Medical Futures Innovation Award The Positive Mental Attitude (PMA) Football League is an engaging social venture for sufferers of mental illness. Created by former professional footballer and coach, Janette Hynes in 2005, the PMA aims to help its players achieve better physical and mental health, thus enabling recovery and reintegration into the community. Since winning her Award, Janette’s London based pilot has been professionalised and a review of activities demonstrated that of the 350 participants in its first two years, a staggering 75% returned to meaningful education or employment as a result.

The PMA League has now partnered with the Football Association, the Football Foundation and the NHS to ensure secure funding and a joined-up approach to the use of football as a tool to help sufferers of mental illness. As part of her Award, Medical Futures has mentored Janette and her team and assisted the restructuring of the PMA from a London based activity into a scalable national activity with a growing waiting list of teams eager to join. A fly on the wall documentary is being filmed and is soon to be televised. This includes footage

of the day Janette received a letter from the Queen, honouring her with an MBE for services to disability, as well as a friendly match between the PMA’s Hackney Football Club and the UK Parliamentary Football team. The PMA has widened its remit to include other sports and is providing skills programmes with employment opportunities. Over 1,000 individuals with a mental health diagnosis have benefited from the PMA sports programme to date, with an outstanding success rate in helping players succeed in engaging in further education, training, voluntary and paid work.

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