20+20 Vision

Page 60

Meet the Neuronauts After publication of the 1991 Science paper introducing functional MRI and the worldwide embrace of the new imaging technology, the ever-restless Jack Belliveau continued to break new ground. Armed with the understanding that “no single technique would be able to capture the symphony of the human brain,” as Randy Buckner said during the 2014 memorial symposium honoring Belliveau’s life and work, he started down the path of what we know now as “multimodal” functional imaging. At the time, the Martinos Center was still primarily an MRI-based facility, so in order to explore the integration of functional MRI and other imaging modalities—EEG, MEG and PET—he traveled across the US and indeed around the world establishing collaborations with leading experts who were pioneering multimodal imaging with those modalities. This multi-institutional team came to include Belliveau’s group at the Martinos Center; the Dynamic Neuroimaging Laboratory at Einstein College of Medicine in New York with Gregory V. Simpson and colleagues; the Low Temperature Laboratory/BioMag Laboratory at Helsinki University of Technology/Helsinki University Hospital with Risto Ilmoniemi, Hannu Aronen and colleagues; and the Los Alamos National Laboratory/University of New Mexico group with Chris Wood and John George and their colleagues. The ensuing years were heady times for the team, who were leading the charge in a new era of exploring the human brain directly, sparking advances in understandings of the workings of the brain and the mind for decades to come—and still today. And amidst the constant flurry of activity and the seemingly endless stream of technological breakthroughs, they forged a bond so strong they eventually came up with a slightly tongue-in-cheek name for the small band of intrepid explorers: the Neuronauts. Such is the sense of camaraderie among the members of this group that, decades later, when they learned of the compiling of this book in the summer of 2020, they asked if they could contribute a collective remembrance of those early days of multimodal functional imaging. Following is what they wrote about the Neuronauts and the trailblazing work they did. 56

The concept of the Neuronauts captured the larger picture of what all four lab groups, and others, were doing together. The name was born of a large number of trips to Helsinki from Greg’s and Jack’s groups (and many trips to MGH). During these trips we worked for days on end, and enjoyed late evenings together, sharing our dreams and visions. The camaraderie was tremendous—we were so excited to see the results of the first-time integration of our methods. Now we knew what was possible and could imagine what would unfold in the future. The promise of what lay ahead was truly inspirational. We worked hard together, sharing the frequent frustrations, trying to get things to work, and celebrated the functional imaging results that had never been seen before. We thought big and speculated wildly. The thrill of pushing into new frontiers of science got us thinking about having a name for all of us. Like astronauts exploring space we were making it possible to explore the human brain directly in new ways—Neuronauts! The name came to us one night over dinner and salmiakki in Helsinki when Jack, Greg and his student John Foxe, and Risto and his student Seppo Ahlfors were “brainstorming.” We played around with a logo (Greg drew it up on some lab graph paper) to capture the modalities in a whimsical way. The idea of the Neuronauts represents the camaraderie that comes from our years of hard work and success together and the joy of speculating about what it means in the future. We lost our colleague Jack in 2014. Jack’s enthusiasm is still alive in all of us.


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Articles inside

Detecting Consciousness in Unresponsive Patients with COVID-19

3min
pages 212-213

Will Social Distancing Have a Lasting Impact on ‘Personal Space’?

4min
pages 208-209

AI Measures COVID-19 Lung Disease Severity on Chest X-Rays

3min
pages 204-207

The Martinos Center Responds

3min
pages 194-197

2020 (Introduction)

1min
pages 192-193

The Center’s Bruce Jenkins: Born to Be Wild

2min
page 191

The Secret Lives of Martinos Folk: Carol Barnstead & the Center’s cast of colorful characters

5min
pages 188-190

The State of the Center Today

1min
page 184

The Spark (Introduction)

1min
pages 182-183

Learning to See: AI Technique Dramatically Improves the Quality of Medical Imaging

3min
pages 180-181

Artificial Intelligence Improves Treatment Monitoring in Patients with Glioma

4min
pages 178-179

Artificial Intelligence (Introduction)

1min
pages 176-177

Structural Connectivity and Alzheimer’s Disease

1min
page 172

Buckle Up: With New Techniques, MRI is Faster than Ever Before

2min
pages 170-171

Studying Anxiety and Depression with Diffusion MRI

4min
pages 166-169

The Roots of Diffusion Imaging

3min
pages 164-165

Diffusion Imaging (Introduction)

1min
pages 162-163

The Secret Lives of Martinos Folk: Zeynab Alshelh fights stereotypes of women in Islam, one karate kick at a time

4min
pages 160-161

The Possible Role of Glow Sticks—Yes, Glow Sticks—in Treating Alzheimer’s

1min
pages 158-159

Imaging Interactions between Genes and the Environment

2min
pages 156-157

Moving Beyond Biopsy for Liver Fibrosis

3min
pages 152-154

Advancing PET Imaging with Quantitative Methods

1min
page 149

Imaging at the Molecular Level

4min
pages 146-148

Molecular Imaging (Introduction)

1min
pages 144-145

3 Things You Didn’t Know About David Cohen and MEG

3min
pages 142-143

MEG Method May Hold the Secret to Baldness

1min
page 140

Diagnosing and Treating Epilepsy, Other Disorders

2min
pages 138-139

Improving Communication Skills in Autism

3min
pages 136-137

The Music of MEG

4min
pages 128-131

MEG (Introduction)

1min
pages 126-127

The (Nearly) Lost Art of Scientific Glassblowing

3min
pages 124-125

The Road to MPI

3min
pages 122-123

Extremity Scanners and ‘Moving’ MRI

3min
pages 120-121

MRI at Bedside

3min
pages 118-119

New, Portable Scanner to Bring MRI to the Patient

3min
pages 116-117

Low-Field & Novel Imaging (Introduction)

1min
pages 114-115

The (Totally True) Legend of Thomas Witzel and the Ultrahigh-Field MRI Quench

3min
pages 112-113

Ultrahigh-field MRI and Multiple Sclerosis

2min
pages 108-109

7T MRI Memories

1min
pages 102-103

7T at the Martinos Center: An Origin Story

3min
pages 100-101

Larry Wald and the Three Traumas

4min
pages 98-99

Ultrahigh-Field Imaging (Introduction)

1min
pages 96-97

The Secret Lives of Martinos Folk: The Masked Scientist

3min
pages 94-95

Nutrition and Brain Growth in the Developing World

5min
pages 90-93

Estimating Tumor Boundaries with Fluorescence Lifetime Imaging

2min
pages 88-89

Maintaining Cerebral Blood Flow During Cardiac Surgery

3min
pages 86-87

Seeing the Light with Optical Imaging Technologies

6min
pages 80-85

Optics (Introduction)

1min
pages 78-79

The Secret Lives of Scientists: Anastasia Yendiki

2min
pages 76-77

'Women in Science' Group Tackles Sexism, Other Issues

4min
pages 74-75

Predicting Cognitive Decline in Alzheimer's Disease

2min
pages 70-71

The First 20 (Plus) Years of FreeSurfer

9min
pages 64-69

FreeSurfer (Introduction)

1min
pages 62-63

Meet the Neuronauts

3min
pages 60-61

Understanding the Patient-Clinician Relationship

2min
pages 58-59

What Is ‘Covert Consciousness’ and Why Is It So Important?

2min
pages 56-57

Eye-Contact Avoidance in Autism

3min
pages 54-55

The Neuroscience of Personal Space

5min
pages 52-53

Is Functional MRI the New X-Ray Vision?

3min
pages 50-51

Building 75 Opens Its Doors

1min
pages 46-47

Martinos Staff

1min
pages 44-45

In Memory of Athinoula

4min
pages 38-39

The Martinos Gift (Introduction)

1min
pages 36-37

Behind the Cover: The Story of the Original fMRI Image

3min
pages 34-35

Captivating Tales from the Pioneer Trail

1min
page 33

The ‘Unassuming’ Ken Kwong and a Pivotal fMRI Breakthrough

8min
pages 28-32

The Life and Science of Jack Belliveau

8min
pages 22, 24-27

The Foundations of Functional MRI

2min
pages 20-21

Functional MRI: Origins (Introduction)

1min
pages 18-19

A Brief History of the Charlestown Navy Yard

4min
pages 16-17

The Birth of a Center

7min
pages 10-13

The Early Years (Introduction)

1min
pages 8-9

Functional MRI: Applications (Introduction)

1min
pages 48-61

Message from the Director

2min
pages 6-7
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