SARMsPharm Therapy Shows Large Muscle Gains The way to big, strong muscles is long and requires hard work in a gym. But researchers may have found a shortcut where in actuality the muscles grow by themselves. Scientists have actually succeeded, by way of gene therapy, to boost the lean body mass and the effectiveness of macaque monkeys. The experiment was simple enough, the researchers just injected the gene follistatin (FS344) directly into the monkeys right thigh muscles. It has been shown that follistatin can block myostatin, a molecule that down-regulates musclegrowth, but strengthens tendons. Eight weeks after the injection the circumference of the monkeys right thigh muscles, had on average risen 15 percent in contrast to the left thigh. A study done on two of the monkeys showed that musclestrength in the right leg was increased by respectively 12 and 36 per cent compared to the untreated leg! The Follistatin is injected by way of a viral vector, that is a Adeno Associated Virus used as a transport for the drug that's injected. It is really a common method called Gene Therapy, and has been utilized in humans with other drugs. The analysis on the monkeys showed no negative side effects. This therapy has been developed for used in patients with severe muscle dystrophy and other muscle wasting disorders. Clinical trials on humans are due to begin in 2011 and Nationwide Childrens Hospital in Ohio has recently gained funding for the study. You will find several studies and clinical trials either underway or planned for treatment of muscle wasting disorders, among some of the more interesting substances are Follistatin as an antagonist to Myostatin, Ostarine which is really a SARM(Selective Androgen Receptor Modulator) and is currently in Human clinical trials by GTx Inc. and also another SARM under the codename BMS-564,929 which will be being manufactured by Bristol-Myers Squibb. The prospect of these substances to be abused by athletes has prompted the World Anti-Doping Agency to really have a ban on SARMs since 2008. Sofar only the substance known as "SARMs S4" (Andarine) has caused it to be to the market, and has been used by a small amount of pro and amateur bodybuilders, it's anabolic effects are said to be moderate and it has been reported to possess some temporary negative effects, among which decreased night vision may be the more prominent. The future of drugs developed for muscle wasting diseases are sure to be of interest for athletes and others wanting to get the excess advantage. The next 5-10 years might find various substances turn LGD-4033 buy out and some might be good replacements for Anabolic steroids. These drugs will soon be available through the black market for pro and amateur athletes alike, with
unprecedented anabolic effects and near to no negative side effects.