DRIfocus Newsletter Summer 2014

Diabetes Research Institute Foundation Summer 2014/ Volume 41 / Issue 2

DRIfocus Join us on social media!

PILOT CLINICAL TRIAL WILL TEST A NEW SITE IN THE BODY FOR A DRI BIOHUB PLATFORM In 2013, the Diabetes Research Institute and Foundation announced the next step in our approach to discover a biological cure by developing a DRI BioHub – a bioengineered “mini organ” that mimics the native pancreas, containing real insulin-producing cells that sense blood sugar and release the precise amount of insulin needed, in real time, together with critical components that keep the cells safe, healthy and functioning long term.

The BioHub is a platform approach that builds upon decades of progress in clinical islet transplantation and holds the promise of achieving a practical cure by restoring natural insulin production in millions of children and adults living with diabetes.

Over the last year, DRI Director Dr. Camillo Ricordi and his team have been investigating an optimal location within the body to house a BioHub. Currently, islets are transplanted into the liver, but that site is not an ideal home for the cells. One area of focus is the omentum, an apron-like lining inside the abdomen. DRI researchers believe that the omentum may be an ideal location for a BioHub. “The omentum is a very vascularized tissue that is easily accessed surgically, and most importantly, has the same blood supply and drainage characteristics of the pancreas,” said Dr. Ricordi.

Encouraging preliminary data in experimental and preclinical models has shown that islets in the omentum can engraft and improve blood glucose control.

“We have observed long term survival and function of the islets in this site,” said Dr. Dora B e r m a n - We i n berg, a member of the DRI’s Cell Transplant Center, who conducted these experiments with Dr. Antonello Pileggi, director of Preclinical Cell Processing and Translational Models, and their respective teams.

"We were able to establish and optimize a protocol for implanting islets onto the surface of the omentum. Preliminary islet transplantation studies in experimental models of diabetes confirmed the feasibility of the approach," said Dr. Pileggi.

This exciting research is now moving to patient trials. The DRI has received approval from the Food and Drug Administration to proceed with a Phase I/II clinical trial that will test the omentum as a possible transplant site for a DRI BioHub. In this pilot trial, researchers will transplant insulinproducing islet cells within a “biodegradable scaffold,” one of the approaches considered for a BioHub platform.

Continued on Page 9

The Biggest Loser

Ray of Hope

Kickin’ It at Kids’ Carnival

Celebrating 40 years

30 Years of Support

Lesley Carey, president of The Biggest Loser Resorts, and Bobby Saleem, finalist from NBC’s The Biggest Loser, at the DRI Walk presented by Walgreens.

Shannon and Ray Allen of the Miami HEAT, with Dr. Camillo Ricordi, before their events, co-chaired by Andria and Javier Holtz and presented by Hublot.

Disney star Dylan Riley Snyder of the TV show Kickin’ It with Willa Besner at the Northeast Region’s Kids’ Carnival for a Cure.

Music legend Barry Gibb performed an exclusive concert for a sold-out crowd at the 40th Anniversary Love and Hope Ball.

Sports commentator Boomer Esiason with WCBS2 News anchor Chris Wragge at the 30th incarnation of the Real Estate industry’s Empire Ball in NYC.

> Articles on pages 14 & 15

> Article on page 16

> Article on page 17

> Article on page 18

> Article on page 19

A Message

from the Chairman Dear Friends, As we close this fiscal year and head into summer, we do so poised to begin a pilot clinical trial that will test a new transplant site in the body to house a DRI BioHub. We have been eagerly anticipating this trial and are pleased to share this news with you.

DRI researchers will transplant islets within a biodegradable scaffold, one of the approaches considered for a BioHub platform. This promising research is being translated to patients with T1D after demonstrating encouraging results in experimental models. In addition to the information contained in the cover story, more details about the biodegradable scaffold can be viewed in our BioHub video, DiabetesResearch.org/BioHub. While this clinical trial is certainly a highlight of what has been a very busy year, there is other good news to share.

In our last issue, we introduced the DRI Foundation’s new president and CEO Joshua Rednik. Josh, whose message appears below, has spent the last six months familiarizing himself with our organization, donors, and volunteers, as well as countless D-families. He has taken the helm of the DRIF at a most exciting time and I, together with my board colleagues, have the highest confidence in his ability to lead with distinction and integrity.

Speaking of leadership, in this issue we acknowledge a number of individuals who exhibit that trait through their service to the DRI. No one has exemplified that role more than Sonja Zuckerman, who served as Life Chairman of Love and Hope for 40 years. Sonja, who was also a member of our National Board of Directors, has spent her life helping the DRI fulfill its mission to cure diabetes and we are exceedingly grateful for everything she has done for us.

A history of commitment also defines our relationship with North America’s Building Trades Unions, which have demonstrated that strong

leadership can organize a force of millions to rally for our cause. Their dedication to the DRI remains strong, as so many union members are personally affected by diabetes.

New York Times best-selling author Brenda Novak celebrated the 10th year of her Online Auction for Diabetes Research, which resulted in a record-level of funds raised.

In our Florida Region, board members like Crystal Blaylock Sanchez and Rick Tonkinson are leading by example. So is Greg Besner, who we recently welcomed to our Northeast Board.

Earlier this year, the Allen and Holtz families joined forces to lead two successful events, the Ray Allen Golf Classic and Ray of Hope Luncheon, both held the same day.

And while he is only 13, Jonathan Berman is already undertaking his second fundraising initiative for the DRI with his Power of One program.

Around the country, our Diabetes Diplomats are leading projects that are personally meaningful to them as they raise critical funds for research.

These individuals, together with the donors, committee members, and other volunteers featured in this issue, are taking the concept of leadership to new heights. Suffice it to say that we will all benefit from their – and all of our – collective efforts to provide the DRI with the resources needed to cure this disease. Thank you again for your support and continued generosity. Best wishes for an enjoyable summer!

Sincerely,

Harold G. Doran, Jr., Chairman of the Board

PRESIDENT’S MESSAGE Dear Friends, As I sat down to draft this letter, I marked the six month anniversary of joining the DRI Foundation as president and CEO. Needless to say, that period of time has passed quickly. Such is life when you are learning so much that is new and exciting.

Of the many things that I have witnessed in my tenure thus far, two stand out.

First, as someone who did not have a close personal connection to diabetes prior to joining the DRIF, I have quickly come to understand how the disease impacts everyone who lives with it daily, as well as the people who love and support them. It is an insidious and immensely challenging illness to live with, and while we celebrate advances in management when they come, such improvements are not a cure.

Second, the DRI is unique. I have no doubt that we are the most comprehensive diabetes research center in the world, uniting a team of researchers with an array of expertise so that they together then can focus solely on discovering a biological cure. The fact that we collaborate with other leading research centers around the world only cements our distinct place in the diabetes community.

I am keenly aware of the challenges that lie ahead in continuing to pursue that biological cure. Of course, chief among them is the need to ensure that our researchers at the DRI have the resources they need to pursue their work in earnest, with dedication and focus. This is work we cannot do alone. Your assistance – your donations in support of our research, your sponsorship of our events, your serving as ambassadors to those you know within and outside of the diabetes community, and more – is nothing short of critical.

To say that I have been touched and inspired by what I have experienced during my tenure thus far would be an understatement. I am convinced that our work has the capacity to change the world, for people with diabetes and beyond. I am grateful for the warm welcome I have received and I look forward to your feedback, questions, and support. Thank you.

Sincerely,

Joshua Rednik, President and CEO

GREG BESNER JOINS THE NORTHEAST BOARD OF DIRECTORS The Diabetes Research Institute Foundation is pleased to announce the appointment of Greg Besner of Short Hills, NJ, to its Northeast Board of Directors.

Greg has been the founder and CEO of several successful technology and consumer product companies. He most recently launched a new software company called CultureIQ, Inc., to help companies use data to manage, measure and improve their corporate culture. He is also an adjunct professor of entrepreneurship at New York University, teaching a class called, “Ready, Fire, Aim.” Prior to becoming an entrepreneur, Greg served in the capacity of president, COO and CFO for several other successful companies and had a prosperous career on Wall Street working at Goldman Sachs and then Merrill Lynch. Prior to launching CultureIQ, Greg was the CFO of New York-based SecondMarket Holdings, Inc. Before SecondMarket, Greg led a group of private investors in the Series B funding of House Party, Inc., a growth stage digital media company, where he served as COO from 2009-2010. Prior to joining House Party, Greg was the founder and CEO of Computershare Executive Services, a SaaS fin-tech company formally known as Restricted Stock Systems, Inc. (“RSS”), from 2000 until 2009. In 2007, Greg sold RSS to Computershare Limited, a public company based in Australia, and he remained as president until January of 2009. During his tenure as CEO of RSS, Greg was named the Ernst & Young 2003 Entrepreneur of the Year in New Jersey.

Greg is also an active investor and consultant for numerous successful companies and start-ups. Of note, he was an investor and consultant for Zappos.com starting in 2005 until Zappos was sold to Amazon in 2009. Greg currently serves on the Board of Directors or the Board of Advisors for 10 privately-held companies and also serves on the Board of Directors of the Young Presidents’ Organization (“YPO”) NJ Chapter. He is the founder and CEO of Leslie Hsu LLC, a fashion accessories company that he and his wife, Leslie Hsu Besner, founded in 2000.

It’s fair to say that Greg is fueled by ambition and the drive to succeed. But to those who know him personally, it’s clear that his true motivation stems from a desire to fulfill the one wish of his eldest daughter, Willa – finding a cure for her type 1 diabetes. Through their family foundation, Willa’s Wish Foundation, Inc., they have made multiple major gifts to advance research being conducted at the Diabetes Research Institute. They host an annual event in NYC, Cocktails for a Cure, to be held September 13, and have sponsored several of the DRI Foundation’s Northeast events.

Willa (see photo on cover) appeared in the DRIF’s Future Free from T1D campaign video last year, and her little sister, Lana, has also been involved with their fundraising efforts.

BOARD SPOTLIGHT: CRYSTAL BLAYLOCK SANCHEZ Florida Region Board member Crystal Blaylock Sanchez wears many hats — head of a family-owned business and a major, annual fundraising event, plus mother to two boys, Cameron and Matthew. Possibly the most important and challenging job she handles is “backup pancreas” for Matthew, who was diagnosed with type 1 diabetes in 2005 at age 5.

As president of Blaylock Oil and executive director of the Shell Key West Challenge, which has raised more than $500,000 for the Diabetes Research Institute (see page 19), Crystal could easily rest on her laurels and avoid adding anything else to her very full plate. Her drive, however, to find a cure for her son and millions more is always at the core of every step taken and each decision made.

Crystal Blaylock Sanchez with her boys, Cameron and Matthew.

“Bottom line is I want a cure for Matthew and everyone else who suffers with diabetes, and we believe in the DRI,” she said with conviction, which is exactly what motivates those around her to support her cause.

Surrounding her personal efforts is an impressive grassroots fundraising circle of friends, colleagues, vendors and other wholesalers who have contributed additional dollars to the DRI. From programs like Pump for a Cure, Dollars for Dolphins, and Pucker for a Cure to church and restaurant fundraisers, “Cure” ring sales and a Fish Skinz tournament, Crystal has inspired so many others to commit to fundraising projects for the DRI. Furthermore, she always steps to the plate when asked to participate in the DRI Foundation’s campaigns, photo shoots, videos, and special events.

“The support I’ve received from family and friends is very humbling. But it’s because we know that whether its $5 or $500, it goes to research for a cure. No fundraiser is too small or insignificant. Every amount helps, and we can all contribute to the end result that I’m very much looking forward to — a cure.”

3 |

CERTIFIED FINANCIAL PLANNER™ RICK TONKINSON MAKES A BEQUEST OF HIS OWN With over 25 years of experience in wealth management, Rick Tonkinson understands planned giving. He is the president of Tonkinson Financial, a family business that provides a common-sense, realistic and encouraging approach to the financial issues of his clients, who come from middle class families with less than $1 million in assets. Rick has continued to demonstrate his business savvy, kindness and passion for the Diabetes Research Institute. Recently, he established a $1 million bequest to benefit the DRI. But as Rick says, “You don’t need 25 years of experience to make a planned gift.

Virtually anyone can make one.”

Rick learned the value of a dollar delivering newspapers for Newsday in Long Island at the age of 12. He credits his spirit of community and giving back to his New York upbringing and his mother as a role model. Rick says his mother was the biggest influence in his life and, although she passed away in 1974, people still remember her kindness.

Determined to live up to the virtues of his mother, Rick joined the Peace Corps after graduating from Pennsylvania State University.

While volunteering with the Peace Corps in Colombia he met his wife, Margarita, who was a high-level executive in Colombia’s port author-

ity. In 1981, Rick and Margarita moved to Miami with their son, Steven.

Since then, Rick has made a huge impact on the South Florida community.

In addition to being a member of the DRI Foundation’s Florida Region Board, Rick is a major donor to 30 charities in the local community. He serves as chairman of the FIU College of Architecture and the Arts Advisory Board as well as a board member at the Arsht Performing Arts Center and trustee to the Cleveland Orchestra. Rick is committed to tithing 10 percent of his gross income to the community.

Although Rick is passionate about all the organizations he supports, the DRI in particular is a top priority for him. “I am convinced that researchers at the DRI will find a cure for diabetes,” he said. “And once they get a grip on the source, other related illnesses can also be cured.” Rick says the DRI’s transparency and collaborative relationships with researchers around the world allow him to sleep well at night, knowing his funds are going to the right place. Recognizing the DRI’s need for immediate funding, Rick and Margarita also have recently made a $150,000 contribution that will elevate them to the DRIF’s Distinguished Humanitarians giving society, which honors those whose cumulative contributions range from $250,000 to $499,999.

Rick discovered he had diabetes at 51, just six months after climbing Mt. Kilimanjaro with his son, Steven. He thanks Dean Pascal Goldschmidt for referring him to the DRI when he was tired of the status quo and searching for an organization with a comprehensive approach to combatting diabetes. Rick’s diabetes was out of control when he first began treatment at the DRI. He credits Dr. Alessia Fornoni for finding a life-saving link between his kidney disease and diabetes, the team of Dr. Bresta Miranda-Palma and Allison Wick for communicating with him regularly to help him successfully manage his blood glucose levels, and Dr. Juan Dominguez-Bendala for being his health conscience. Rick says, “We talk a lot about the DRI family, and I truly believe in it. I am willing to give not only for analytical reasons but for the emotional connection I have with everyone involved, including the magnificent staff.”

Motivated by his fellow board members and their long-time commitments, Rick pledges to be even more generous as he becomes more prosperous. He invites everyone to join him in supporting the DRI as we advance toward a cure. For tips from Rick about making planned gifts, please see our Q&A with him on page 8.

Margarita and Rick Tonkinson receiving a Cycle of Discovery award; see page 6 to learn more about this award series.

BE THE HERO… JOIN THE DIABETES DIPLOMATS Diabetes Diplomats are a league of students, teachers, parents, grandparents, and other family members and friends who are taking the search for a cure into their own hands. They come from all over the world and serve as advocates, educators, and event fundraisers in their schools, neighborhoods, and online. Some have diabetes. Some don’t. But they have all decided to “Be the Hero” by supporting the Diabetes Research Institute in its mission to cure this disease that affects 29 million children and adults in the U.S. alone. Learn more at DiabetesResearch.org/DiabetesDiplomats.

1

2

The fight for a cure took center stage at the Miami Children’s Theater in Miami, FL, on February 21 in a special fundraising night during the production of How to Succeed in Business Without Really Trying. This was not “children’s theater” as you might imagine it, and the lead actor, Sammy Schechter, was no ordinary talent. He has type 1 diabetes. He and his parents, Rosa and Benno Schechter, were responsible for this evening benefit, where 25 percent of ticket sales plus generous donations from the audience were donated to the DRI. After playing the role of “Finch,” Sammy addressed the crowd directly, talking about how diabetes has affected his life and how important a cure is to the millions living with this relentless disease.

The Rosenberg family of New Jersey – Greg, Denise, Ally, and twins Jake and Jesse – continues to think of new ways to support the DRI Foundation. Jesse and his friend Matthew Weksler are forming a club at their high school to raise awareness about type 1 diabetes. They’ve already held two fundraisers – a school bake sale and the 3rd annual Spin for a Cure (originated by the Rosenberg children) at The Gym in Englewood, NJ. Jesse’s brother Jake and his friends participated, as did the entire Rosenberg family. Jesse and Matt are planning a number of events and speakers for the next school year. And a big shout-out goes to dad Greg for nominating the DRI Foundation as a beneficiary of financial services firm BTIG, LLC’s annual Commissions for Charity Day. These various events and activities raised more than $8,000 for the DRI Foundation, for which we say, thanks so much, Rosenberg family and friends!

It was a picture perfect birthday celebration for professional photographer Gabriela Bianchini – who put on a special 30th birthday auction of her work in Delray Beach, FL, to benefit the DRI, on January 24.

More than 120 people helped bring in more than $8,000 that evening – which Gabriela held in honor of her youngest brother, Gianni, who has been living with type 1 diabetes since he was 17 years old.

Guests enjoyed fine art, appetizers and cocktails, all while supporting a cause near and dear to Gabriela’s heart. All 31 of her fine art pieces were snatched up – including a big ticket “I Love New York” piece that auctioned for $800. This helped make it her “best birthday ever.”

4

3

It was a record year for the annual Blair County Diabetes Walk/Fun Day in Duncansville, PA, on May 17 with nearly 500 people stepping up for a cure and helping to raise more than $20,000 for the DRI. The event was created and is organized yearly by Lisa Treese, whose 10-year-old son, Zach, was diagnosed with type 1 diabetes at age 3. Participants, which included many family teams honoring a loved one with type 1, enjoyed a fun family day of walking, Zumba warm ups, free medical exams, a kids’ tent with fun baseball-themed activities and more.

For Debra Roberts, life isn’t a race, it’s a marathon. And each year, she makes it a point to run miles for causes she strongly believes in. This year, Debra decided to honor her father-in-law, Ted, who has lived with diabetes for more than 30 years, by running California’s San Luis Obispo Marathon in April – and raising funds for the Diabetes Research Institute in the process. Debra not only raised $500 during the marathon with the support of loved ones, but she also reached out via Facebook, letters, and her SLO Marathon Babes team to contribute an additional $2,500-plus. She utilized the Diabetes Diplomats website to collect funds for her efforts. But Debra isn’t slowing her pace any time soon! She will continue raising funds for the DRI through the end of the year.

5

1) DRIF's Jill Shapiro Miller, Rosa and Sammy Schechter, Theater Operations Director Tim Fath, Director Ron Headerick of How to Succeed In Business Without Really Trying, 2) Jake Rosenberg, Jesse Rosenberg, and Matthew Weksler, 3) Gabriella Bianchini, 4) Team Yay, 5) SLO Marathon Babes

5 |

FOUNDATION DONORS RECOGNIZED Awards from the DRI Foundation’s Cycle of Discovery series were presented to donors who recently made major gifts. The award program corresponds with the Foundation’s cumulative giving designations. Awards were presented individually and at Foundation events.

1

2

3

8

9

10

RECOGNIZING DONORS THROUGH THE CYCLE OF DISCOVERY As seen in every issue of the DRIFocus newsletter, the Diabetes Research Institute Foundation recognizes donors who have reached various levels of giving with an elegant series of eight crystal sculptures. Each award was selected for its visual portrayal of the scientific journey through the evolution of an idea, aptly named The Cycle of Discovery.

Although no two pieces are exactly the same, each sculpture is an artistic representation of the endless questioning, the complex investigation, the perpetuation of thought, and the significant accomplishments made by DRI scientists who are committed to finding a cure as quickly as possible.

“What I really like about this award series is that it sparks a conversation,” stated Josh Rednik, president and CEO of the DRI Foundation.

“If someone sees this beautiful, crystal award displayed at your office or in your home, it’s an opportunity for you to tell that person why you received it and what the Diabetes Research Institute means to you.”

Donors who make a new gift of $25,000 or more, or whose additional contributions elevate them to a new giving level, are acknowledged with their respective award. Those who have created a legacy by providing for the DRI through their estate plans become members of the DRI Heritage Society and receive a plaque. All individuals, organizations, corporations, and foundations that have reached one of these levels are permanently recognized on one of the DRI’s distinctive walls of honor. DRI Foundation donors at the Founders level and above are also recognized by the University of Miami.

DONOR LEVEL

AWARD

Visionaries Chairman’s Council Leadership Council Governors’ Society Distinguished Humanitarians Grand Founders Founders Benefactors 4

5

11

12

$10,000,000+ $5,000,000+ $1,000,000+ $500,000+

Innovation Validation Perpetuation Translation

$250,000+ $100,000+ $50,000+ $25,000+

Realization Exploration Hypothesis Query

6

7

PERPETUATION AWARD: Joan and William Fishlinger (1) REALIZATION AWARD: Charlie Guigno for Sportsmen for Charity (2) EXPLORATION AWARD: Janie and Ron Kupferman (3), Maria and Eric Reeps (4), Wendy Waller (5) HYPOTHESIS AWARD: Al Amore of Trinity Real Estate (6), Mercedes and David Carlson (7), Jeanne Fibus and Randi Fibus Caster with DRIF's Josh Rednik (not pictured Ken Fibus) (8), Barbara and Norman Shapiro (9), Richard Veltri of United Air Conditioning (10), Rina and Jerrold Weinbrom (not pictured Jerrold) (11) QUERY AWARD: Fran and Howard Helfant (12)

1

2

3

4

5

6

6

8

1) Query, 2) Hypothesis, 3) Exploration, 4) Realization, 5) Translation, 6) Perpetuation, 7) Validation, 8) Innovation

7 |

RICK TONKINSON ANSWERS

YOUR PLANNED GIVING QUESTIONS Certified financial planner™ Rick Tonkinson, president of Tonkinson Financial and member of the Diabetes Research Institute Foundation’s Florida Region Board, provides answers to these frequently asked questions about planned giving.

1. What is a planned gift?

4. What is the most popular planned gift?

A planned gift is a gift to be made in the future that immediately satisfies your philanthropic goals and might improve your financial situation. It can be a bequest in a will or trust, a beneficiary designation of an insurance policy or retirement plan, a transfer on death designation of a bank or securities account, a charitable trust, or a charitable gift annuity.

By far, the most popular planned gift to the Diabetes Research Institute Foundation (DRIF) is a bequest made through your will. When making a bequest, you can designate a specific dollar amount, a percent of your estate, or what is left in your estate after other bequests are fulfilled. It is simple to establish and, because it is revocable, you can make changes at any time.

2. Who can make a planned gift?

Virtually anyone can make a planned gift at any level. I believe there is a perception problem among people that they can’t make planned gifts, but these gifts offer tax advantages for all, regardless of age or financial means.

3. Why should I make a planned gift?

The DRI relies on planned gifts to continue its critical work toward a cure. When you establish a planned gift, you leave a lasting legacy that will extend the benefits of your generosity far into the future and on a much broader scale.

5. How do I make a planned gift?

The DRIF can provide detailed information, including draft language, for your attorney or other advisor regarding any planned gift you are considering. Please contact Jill Shapiro Miller at (800) 321-3437 to arrange for a confidential conversation.

6. If I make a planned gift to the DRIF, must I inform anyone?

It is not necessary for you to inform the DRIF of your plans. However, they are always delighted to welcome a donor to the Heritage Society, which honors those who have demonstrated their commitment to the DRIF with a planned gift (see page 6). As a member of the DRI Heritage Society, you are setting an example for others to follow. Plus, you will receive a plaque that demonstrates your commitment to the DRI, and your name will be inscribed on a wall of honor at the Institute.

Most people can afford to make a planned gift in support of a cause that’s close to their heart even if they plan to provide for family members.

SUPPORT OUR WORK WHILE DOING YOURS Many employers encourage employees to support charitable organizations through workplace giving campaigns. These gifts are tax deductible and can be made through a payroll deduction program. Simply select the DRI Foundation from your company’s charitable choices and encourage your co-workers to do the same. If the Foundation is not already an option, you can further assist by working with us to determine how to go about being included.

For participants in the Combined Federal Campaign (CFC), our number is #11149. We are also listed under the Health 1st America’s Charities Federation. The easiest way to find us is in the alphabetical index at the back of your campaign guide. If your company holds a United Way campaign, you have the opportunity to contribute to the DRI Foundation by utilizing the write-in feature. Please call 1-800-321-3437 or email info@drif.org if you have any questions.

HONORING SONJA ZUCKERMAN

FOR 40 YEARS OF PASSIONATE LEADERSHIP AND LOYAL FRIENDSHIP Who could have imagined that in 1974 when Sonja Zuckerman suggested having a ball to benefit the Diabetes Research Institute, the event would still be going strong 40 years later?

Every charity has its champions, but there is no one more synonymous with the Love and Hope group than Sonja. Serving at the helm of this unparalleled fundraising effort as Life Chairman for the past 40 years, she has helped to raise millions of dollars for the DRI. This year, at the annual Thank You Luncheon for the Love and Hope committee, Sonja announced that she was stepping down from her position.

Though she has no direct connection to diabetes, Sonja has taken on the search for a cure as a personal mission, inspiring countless others to join in her crusade. She served on the DRI Foundation’s National Board of Directors for years and is now an Honorary Board member and a Distinguished Humanitarian of the organization. Her role as Life Chairman of the Love and Hope Committee utilized her fiery spirit, boundless creativity, and impeccable eye for detail.

Born in Cairo, Egypt, Sonja moved to Israel early on and was educated in French schools. By the time she came to the United States, more than 50 years ago, she had mastered seven languages, all with the self-assured authority for which she is known. Versatile and determined, she firmly believed that it was her obligation to get involved in her community.

Before making Miami her home, Sonja was an active participant in important causes in New York, Chicago, and Detroit, where she became the impetus that launched the longstanding Angel Ball, benefiting the National Council for Jewish Women.

In a moving and heartfelt speech at the Thank You Luncheon, Sonja stressed that although she is stepping down from her active role; she is not going anywhere and is always available when needed.

While she will be deeply missed in the leadership position, she has left behind an incredible legacy of wonderful and generous donors and an active and involved committee.

Sonja’s greatest wish is that she will be able to celebrate a cure for diabetes – and to help plan the victory party! To those that have had the privilege of working with her, Sonja Zuckerman has been and will continue to be an inspiration.

PILOT CLINICAL TRIAL

(continued from cover)

The biodegradable scaffold is a combination of a patient's own plasma and thrombin, a commonly used, clinical-grade enzyme. When combined, these substances create a gel-like material that sticks to the omentum and holds the islets in place. This section of the omentum will be folded over and stitched, creating a pouch around the biodegradable scaffold mixture. Over time, the body will absorb the gel, leaving the islets intact, while new blood vessels are formed to support their survival and function. This pilot trial will include the immunosuppressive regimen currently used for clinical islet transplantation studies.

“This is a very important first step in the overall development of the BioHub because this will set the site of implantation and the platform technology. We have to show initially that this transplant can function and be equivalent to the liver as a site of implantation,” explains Dr. Ricordi. “We will then add all the other components that will favor new blood vessel development, oxygen generation, cell protection and other agents that will allow us to reduce and eventually eliminate systemic immunosuppression, which is our goal for a biological cure.”

scaffold,” a sponge-like disc made of clinical-grade silicone – also utilizing the omentum as a transplant site. Researchers are in discussions with the FDA about additional preclinical testing that the regulatory agency has required before approval of that pilot clinical trial in the U.S. can be granted.

“We will test both the biodegradable scaffold and the bioengineered scaffold to see which approach is better and demonstrates greater benefits for patients with diabetes. Both approaches will allow us to add all the components necessary for developing a BioHub mini organ,” adds Dr. Ricordi.

For more information on the pilot trial and to download the Islet Transplantation Application form, please visit DiabetesResearch.org/PilotTrial.

The DRI has also made progress in the other strategic areas comprising the BioHub, which include methods to protect the insulin-producing cells from the immune system, as well as a means of developing an unlimited supply of cells. You can read more about the DRI’s research progress at DiabetesResearch.org/AnnualReport.

The DRI also plans to test another BioHub platform – a “bioengineered 9 |

UNDER THE MICROSCOPE WITH DR. GIACOMO LANZONI The DRI has shown that islet cell transplantation can restore natural insulin production in those with type 1 diabetes. Almost all patients have been able to discontinue their use of insulin and maintain normal blood sugar levels, some for more than 10 years.

However, over time, most of these patients have had to resume insulin therapy. Researchers believe that many of the transplanted islet cells are lost at the time of infusion and in the days following the procedure due to several reasons, among them is a temporary lack of adequate oxygen immediately post-transplant within the infusion site; the harmful inflammation that occurs at the implant site; and the use of harsh anti-rejection drugs, among other reasons.

Currently, researchers do not have a means of locating and measuring how many insulin-producing cells remain alive and functioning in patients who have received islet transplants, or how many cells remain upon clinical diagnosis of type 1 diabetes.

Thanks to new advances in imaging and nanotechnology, DRI researchers are developing and testing a special class of manufactured molecules that can “hone in” on specific cell markers, including those that are unique to insulin-producing beta cells. This new “tool” presents a novel way to transport protective agents only to the desired target. These molecules, known as aptamers, are generated in our labs and designed to bind to the beta cells. Incorporating fluorescent “flags” to beta cell-specific aptamers could allow researchers to detect their location and acquire an accurate measurement of the number of functioning cells in vivo (within a living organism).

Researchers Luca Inverardi, M.D., Paolo Serafini, Ph.D., and Giacomo Lanzoni, Ph.D., are leading the effort. We spoke with Dr. Lanzoni about aptamers’ potential to target beta cells – not only for their imaging potential, but also for their ability to deliver anti-rejection drugs (immunosuppressants) locally, where the islets are placed, like within a DRI BioHub.

munogenic – which means they will not cause an immune reaction.

That’s very important. We do not want an immune reaction against the beta cells.

Q. Why do you consider aptamers to be revolutionary?

A. In addition to the characteristics mentioned above, aptamers can also be developed with amazing speed. Doing the same thing with antibodies would take several years. For example, we developed aptamers for mouse islets in just a few months, and we are now seeing the binding of these aptamers in vivo in just one year within these experimental models. It’s truly remarkable.

Q. How can aptamers be used?

A. We believe we can use them to see beta cells in vivo. As of today, there is no way to visualize insulin-producing cells, nor to know their numbers and location, for example, when transplanted into a recipient.

If we could see them, we could understand a lot more about what is going on during disease progression and after a treatment. We could also follow them at various time points after islet transplantation and treatment.

Currently, the way researchers estimate cell function is to measure the levels of C-peptide, a by-product of natural insulin release. However, these levels do not indicate the number of cells doing the job.

In order to see them, to measure the beta cell mass in vivo, we are tagging the aptamers so they emit light. If they bind to beta cells, we’ll be able to scan the body and see how many and where they are.

Q. How safe are they?

A. Aptamers are already used in the clinical setting for other diseases, so, they have been shown to be safe. But since every single aptamer is different, further research will be needed in order to obtain regulatory approval for this purpose.

Q. What are aptamers?

A. Aptamers are very small molecules that can penetrate deeply into tissues. Think of them as very small programmable drones for delivery: they are revolutionary. We build them in the lab and they’re designed to target something of interest, such as a specific component of a living cell – and they will bind to that. This unique characteristic makes them very useful for beta cell imaging and targeting. We are testing aptamers designed to visualize functioning beta cells within the body in order to quantify their numbers and location. In the future, we would like to use these aptamers for the delivery of protective agents directly to the beta cells themselves.

Aptamers are easy and relatively cheap to produce. Plus, the way we modify them makes them very robust. Moreover, they are non-im-

Q. How do we know they will bind to the correct cells – the ones we’re targeting?

A. We select beta cell-specific aptamers out of literally millions of “random” aptamers. We identify those aptamers that bind with a very high affinity to beta cells, the cell type we actually want to target. During that same selection process, aptamers that bind to other cells and tissues are eliminated.

Q. What’s the current state of this research?

A. We have developed aptamers that bind to these cells in mice. In preliminary studies, we saw the specific binding in the pancreas in vivo. We have sequenced these aptamers, which means we know how

AROUND

THE DRI

to build them. Now we can build up large quantities of them, and for a relatively low price because of the technique we use.

We know that rodent islets are different from human islets, so we have to design different aptamers for humans. We are developing them right now, and we have already been successful in developing aptamers that bind to human islets in laboratory experiments.

Q. What are the next steps?

A. We have selected aptamers that bind to islets. But islets are clusters of several types of cells. So, now we need to identify which aptamers bind specifically to beta cells (the cells that produce insulin), which aptamers bind specifically to alpha cells (the cells that produce glucagon), and so on.

Q. How could this help patients who receive islet cell transplants?

A. We would be able to see and track the transplanted cells. Today, we know how many cells we infuse into a patient, but it’s not possible to see them and follow what happens to them – where they end up and how many survive. Currently, we assess only the function of islet cell transplants by measuring C-peptide levels in blood samples, but we really do not know if that level is being produced by just a few, over-worked cells trying to keep up with the glucose demands, or if that measurement reflects many cells working efficiently.

Recent studies by groups here at the DRI reported that, despite the use of chronic antirejection drugs, autoimmunity can again be triggered, resulting in the return of type 1 diabetes. So, we believe that this technology will allow us to assess the number of viable beta cells in patients, and evaluate changes over time in the same individual. Also, it could help assess the effectiveness of immunosuppressive drugs or other methods to protect these cells.

THE IACOCCA FOUNDATION AWARDS GRANTS TO DRI SCIENTISTS FOR INNOVATIVE RESEARCH The ability to stop the immune system from attacking pancreatic islet cells is critical for restoring natural insulin production and reaching a biological cure for diabetes. Thanks to recent grants awarded by The Iacocca Foundation, two of the DRI’s scientists who are making important inroads in this critical area will be able to continue their innovative research toward this goal.

Dr. Alice Tomei, research assistant professor of surgery and member of the DRI’s bioengineering team, is investigating ways that cancerous tumors evade destruction by the immune system with the goal of using that “escape mechanism” to protect insulin-producing cells. Dr. Tomei and her team have published key findings in the journal Science demonstrating that tumors secrete the molecule CCL21, which is naturally found in lymph nodes as a mechanism of self protection. Armed with this important information, the team has performed additional studies and has found that CCL21 expression in beta cells (the insulin-producing cell component within islets) completely prevents type 1 diabetes in experimental models. The funding award from The Iacocca Foundation will allow Dr. Tomei and her team to build upon this groundbreaking research.

Dr. Peter Buchwald, director of drug discovery, is targeting a recently identified signaling pathway that leads to autoimmune destruction of insulin-producing cells. He and his team have had promising results in experimental models demonstrating that new-onset diabetes can be reversed by blocking this pathway with a protein known as Smad-7. There is also scientific evidence supporting his theory that the use of Smad-7 not only controls the autoimmune destruction of the islet cells, but can also lead to islet regeneration. With the funding from The Iacocca Foundation, Dr. Buchwald and his team will focus on investigating the possible beta cell-enhancing effects of this treatment with the goal of quickly translating this research to clinical therapies.

DRI’S DR. SKYLER PRESENTED DISTINCTION IN ENDOCRINOLOGY AWARD Jay S. Skyler, M.D., M.A.C.P., received the Distinction in Endocrinology Award at the American Association of Clinical Endocrinologists (AACE) 23rd Annual Scientific & Clinical Congress in Las Vegas on May 15, 2014. The award is given to an AACE member in recognition of advancing the understanding of endocrinology through research and education.

Dr. Skyler has focused his research on immune intervention and beta cell expansion or replacement. He is the chairman of the NIH-sponsored network that conducts clinical trials internationally in efforts to prevent type 1 diabetes.

"I am deeply honored to receive this award,” said Dr. Skyler, who is the deputy director for Clinical Research and Academic Programs at the Diabetes Research Institute. “It is particularly gratifying to join the list of distinguished previous recipients."

11 |

BUILDING TRADES’ SUPPORT CONTINUES “MOVING TOWARDS A CURE” 2

1

The historical and unparalleled partnership between North America’s Building Trades Unions and the Diabetes Research Institute and Foundation continues to reach new heights. Earlier this year, the Building Trades held their 2014 Legislative Conference at the Washington Hilton & Towers Hotel in Washington, DC. President Sean McGarvey invited DRIF’s Joshua Rednik and Tom Karlya to attend, and they were humbled by the outpouring of support from the more than 3,000 representatives there.

vision for the Institute – a state-of-the-art center where scientists would have every tool necessary to conduct their research. Without delay or debate, Blueprint for Cure was born.

The relationship reached a major milestone when the men and women of the Building Trades funded – and built – the DRI facility in Miami, which continues to be the most comprehensive diabetes research center of its kind in the world.

“The presentation about the Diabetes Research Institute came right after former President Bill Clinton addressed the crowd. You can imagine what it’s like to follow him! But when our DRI video played, featuring several kids with diabetes talking about their fears, their concerns and their hope for a cure, you could have heard a pin drop,” said Karlya. “The support of the Building Trades is immeasurable, and I was struck by the emotion in the room and the pride each member so obviously felt. They won’t stop until the DRI finds a cure for diabetes.”

Today, the vision for Blueprint for Cure (comprised of DADs Day events occurring around the country and the national organization’s Labor of Love weekend) is a diabetes-free tomorrow. Its mission is to unify the fundraising efforts of local labor councils and their communities around the country through increased communication and event support. Next up? Look for coverage of the Labor of Love & Softball Slam, which took place June 20-23 in Atlantic City, NJ, in the next issue of the DRIfocus newsletter as North America’s Building Trades Unions continue “Moving Towards a Cure.”

Each year, two unions are recognized for their fundraising efforts, as part of the DAD’s Day campaign (Dollars Against Diabetes). Members of IBEW Local 26 and the Minneapolis Building and Construction Trades Council were recognized for their highly successful golf tournaments and for their dedication to the cause.

1) Brent Booker, secretary-treasurer, North America’s Building Trades Unions, Tom Karlya, vice president, DRIF, Josh Rednik, president and CEO, DRIF, Dan McConnell, business manager, Minneapolis BCTD, Paul Klesmit, chairman of the Minneapolis event, Sean McGarvey, president, North America’s Building Trades Unions, Butch Ramos, president, IBEW Local 26, Chuck Graham, business manager, IBEW Local 26

The Building Trades' support stems back to 30 years ago when union representatives met with a handful of parents from the DRI Foundation, all of whom had children living with diabetes. They explained the grand

2) This is a scene from the DRI video that played at the 2014 Legislative Conference featuring 5-year-old Olivia who has type 1 diabetes. Wearing a hard hat, she adoringly blows a kiss and thanks the Building Trades for their support.

GATHERING IN DELRAY BEACH Approximately 60 people gathered at the Delaire Country Club in Delray Beach, FL, to learn more about the cure-focused work of the Diabetes Research Institute and the development of a DRI BioHub. In a presentation titled, “Reaching the Biological Cure: Resolving the Remaining Challenges,” the DRI’s Dr. Antonello Pileggi reported on protection of cells from harmful immune system attack, how to increase the supply of cells for transplant, and stopping the autoimmune process that caused the onset of diabetes. He spoke about how the DRI BioHub, an integrated mini organ that mimics the native pancreas, addresses critical research challenges and holds the promise of restoring natural insulin production in millions of children and adults. Upon conclusion, guests asked questions and spoke directly with Dr. Pileggi, who is the director of Preclinical Cell Processing and Translational Models at the Cell Transplant Center of the DRI.

PARENTING ROLES AFTER DIAGNOSIS By: Dr. Gary Levenston of the PEP Squad It really is true that it takes a team to care for and support a kid (and a family) with type 1 diabetes. The responsibilities for some team members are relatively limited and are clearly attached to their titles, such as "endocrinologist,” “diabetes educator,” “dietician,” “school nurse,” “clergy member,” “therapist,” or even “pet.” This just does not apply to “moms” and “dads.” There is nothing limited or clearly assigned about the avalanche of new responsibilities and obligations that become obvious in the days, weeks, and months after receiving the diagnosis. There is nothing inherent to “mom” or “dad” that gives much direction, so parents must be proactive in defining their roles and working together on the team.

> emotionally “wise” and nurturing, set the tone for helping your children cope with the many feelings they may experience about the changes that diabetes brings.

How is it for you? In many families, one parent (usually mom) is in the “driver’s seat,” assuming the role of primary caretaker, while the other parent (usually dad) rides “shotgun.” In other families, some moms and dads both want to “drive.” While more challenging, this too can work well. In either case, what happens when the parenting partners want to move at different “speeds” and in different “directions?” What I’m talking about, of course, is when parents have very different styles of solving diabetes-related challenges, parenting their children, and coping with the realities of diabetes.

> business-minded, get involved in fundraising and networking.

How can parents come together as a team when these differences threaten the harmony, stability, and happiness that helps families reach their potential? Here are a few ideas: • Often, there is a very close agreement between parents on the overall goals you both have, but there may be differences about how to achieve them. Find that common ground and come together around that shared purpose.

> verbal and good at communicating, be the one to train school staff on care tasks. > analytical, take the lead on problem solving blood sugar control difficulties. > athletic, put together exercise guidelines for school, camp, and sports teams.

> creative, help your children and family express themselves freely. > funny, find ways to bring lightness and levity to the serious issues your family is facing.

• Recognize that different styles and approaches don’t have to conflict with each other. Explore ways that they can complement each other and benefit your family. Be sure to acknowledge each other for your unique contributions.

However you decide to structure your parenting roles after diagnosis, be proactive and look for the strengths you each bring. This will go a long way in helping your family move beyond the diagnosis and get back to the challenges of raising well-adjusted children, cultivating your relationships, flourishing as families, and leading safe, healthy, and fulfilled lives.

• Play to your individual strengths. For example, if you are more...

Dr. Gary Levenston is a clinical psychologist living in South Florida whose family has been impacted by type 1 diabetes.

> detail-oriented and organized, order the diabetes care supplies, write up the treatment guidelines for school staff, or track health care expenses. > assertive and diplomatic, be an advocate for your child’s needs at school and elsewhere.

“PARENTS EMPOWERING PARENTS” WITH NEWS YOU CAN USE TODAY In May, the Journal of the American Medical Association (JAMA) released the results of a study conducted from 2001-2009, confirming that the incidence of type 1 and type 2 diabetes has drastically increased among children and adolescents. The study found that the prevalence of type 1 diabetes increased an alarming 21 percent in youth under the age of 20.

This sizeable upsurge adds to the urgency of finding a cure now. While scientists at the Diabetes Research Institute work fervently toward that end, we also know how essential emotional support is now for the families living with diabetes.

Whether you’re a newly diagnosed or an experienced “diabetes family,” the PEP Talk eNewsletter can offer up just the right advice or can be a

needed refresher on something you learned long ago. The PEP Talk distributes biweekly and features news and tips on positive language, effective communication, dealing with feelings and other psycho/ social issues. Become a DRInsider and subscribe to PEP Talk: DiabetesResearch.org/Register Looking for personal connection? There’s always someone to talk to on the Diabetes Research Institute Foundation’s PEP Squad closed group page on Facebook. Whether you have a question after a 3 a.m. BG check or you need advice on a school issue, you can usually find another parent who can instantly chime in with an anecdote, encouragement, or guidance. Join the group: Facebook.com/groups/PEPsquadDRI

13 |

WALGREENS, BIGGEST LOSER RESORTS AND THE SOUTH FLORIDA COMMUNITY STEP UP FOR A DIABETES CURE 1

Raising more than $1.5 million toward finding a cure for diabetes has been a work of love, dedication and the fruit of a growing four-year partnership between Walgreens of South Florida and the Diabetes Research Institute Foundation. This year, an additional $500,000 was raised through the sale of “scannables” in Walgreens stores across South Florida, family teams, raffles, generous contributions from individuals, and corporate sponsors such as Neutrogena, the Miami Dolphins, Sun Life Stadium, PepsiCo, Frito-Lay, NIPRO, Alpina Foods, Red Bull, CocaCola, and Florida Ice, to name a few.

March 8th marked the fourth year of the DRI Walk for Diabetes & Family Fun Day presented by Walgreens, which took place at Sun Life Stadium in Miami Gardens and Tradition Square in Port St. Lucie. It attracted more than 8,600 enthusiastic supporters from all over South Florida and St. Lucie County.

“Walgreens is honored to support the work of the Diabetes Research Institute. We are very grateful to our customers and associates who have been exceptional in supporting our commitment by participating in the DRI Walk for Diabetes & Family Fun Day, as well as supporting our in-store fundraising program,” said Roy Ripak, Walgreens market vice president.

In stores, scannable sales added to the overall efforts by allowing customers at all Walgreens stores from Port St. Lucie down through the Florida Keys to support the cause throughout the month by purchasing DRI-branded "scannables" at checkout. Proceeds from those sales added $272,000 to the funds raised for the walk – and all directly benefited the DRI. “Over the many years, Walgreens has been our partner in promoting, supporting and organizing this event. Thank you to Roy Ripak and the entire team of employees at Walgreens, who have dedicated countless hours to making this event a success,” said DRI Foundation President and CEO Joshua Rednik, during a speech after the walk.

Josh also acknowledged the hard work of family teams who raise thousands of dollars, and assemble their loved ones each year in custom inspirational T-shirts to walk for a cure. This includes this year’s top fundraising families, the Perez and Tacher families.

“Seeing all those individuals, families and communities that rallied around them was truly inspiring, and we’re very grateful for all the families who have pulled together to help us raise funds and bring so many people to support such a special event. You helped us make this the biggest year of this event yet,” stated Josh.

2

This year’s event also included participation of the Biggest Loser Resorts – which sponsored The Biggest Loser 5K RunWalk chip-timed 5K and a grand raffle that gave four lucky winners a weeklong stay for two at Biggest Loser Resorts located across the country. Bobby Saleem, this past season’s finalist from NBC's The Biggest Loser also attended alongside Biggest Loser Resort trainers and staff – who led the warm-up, cheered on participants as they ran and walked toward the finish line, and gave South Florida a taste of what The Biggest Loser Resorts are all about.

“It was a fantastic experience for all of us to be part of this event and support our friends at the Diabetes Research Institute and their remarkable work to find a cure for type 1 diabetes,” said Lesley Carey, president of The Biggest Loser Resorts. “We were also thrilled that it took place in such a vibrant and energetic place like South Florida – which has definitely become one of the potential locations we’re looking into for our next Biggest Loser Resort.”

Along with the walk and Biggest Loser experience, families enjoyed an array of activities; from a Miami Dolphins Football Fun Skills Course, bounce houses, zip lining, rock climbing, a Walgreens health fair where pharmacists answered questions and provided health tips about diabetes care, give-a-ways, and vendors, to carnival rides, and live music. Participants also got to meet and greet celebrities including Miami Dolphins players Olivier Vernon and Marcus Thigpen, plus alumnus John Offerdahl, Miami Dolphin Cheerleaders, Footy from the Footy and Mike Show on 560 WQAM, Froggy from the Y-100 Morning Show, and Nathalie Rodriguez from MIA 93.9 and WIOD Newsradio 610.

1) Left to right: Market Vice President of Walgreens Roy Ripak and President and CEO of the DRI Foundation Joshua Rednik receive a proclamation from Miami District 12 Commissioner Jose “Pepe” Diaz.

2) Walgreens Store Manager and DRI Walgreens Walk Coordinator Clint Smethurst strikes a pose with Miami Dolphins Cheerleaders.

3) A strong show of support for diabetes research from Biggest Loser Resorts Fitness Director and Coach Betty Herberger.

4) Kade Baily (left) supports his friend and classmate, Jace Tacher, who was diagnosed with type 1 diabetes just after his 2nd birthday, as part of Team Jace — the family team with the second highest amount of funds raised.

5) Tyler Perez (right) from Team Tyler, the top fundraising family team of the 2014 walk, poses with his friend and Miami Dolphins Running Back Marcus Thigpen.

3

4

5

LET ME COUNT THE WAYS TO GIVE

1

2

1) The Berman family: Jonathan, Mark, Morgan, Lauren, and Michelle, 2) Jonathan with friend and fellow fundraiser, Tristan Wakefield, at the DRI's Matering Your Diabetes program.

15 |

AGAINST DIABETES 1

the awards dinner. “Everything that you guys have done here today helps this man [DRI’s Dr. Camillo Ricordi] find a cure for us. And one of the great things I learned about him in the lab is that he has people all over the world that are collaborating to eradicate this terrible disease.”

When NBA All-Star Ray Allen isn’t scoring big on the court for his championship Miami HEAT team, he’s doing so off the court for his 7-year-old son, Walker, and millions like him. Ray and his wife, Shannon, have been big advocates for type 1 diabetes ever since Walker’s diagnosis at just 17 months old. From testifying about the importance of research to holding events that raise funds for research, the Allens have been taking shots at diabetes with full force – and they’re not slowing down.

Recently, they joined forces with their friends, longtime Diabetes Research Institute supporters and South Florida philanthropists Andria and Javier Holtz to host and chair the 2014 Ray Allen Golf Classic and Ray of Hope Luncheon presented by Hublot at the exclusive La Gorce Country Club on Miami Beach to benefit the Diabetes Research Institute Foundation and JDRF. More than 700 family, friends and philanthropists came out to support the Allens and Holtzes, including Ray’s fellow HEAT teammates Chris "Birdman" Andersen, Shane Battier, Chris Bosh; LeBron James; and Rashard Lewis; former Heat star Alonzo Mourning, and actress Gabrielle Union, who is also engaged to Miami HEAT's Dwyane Wade.

Guests bid on exclusive silent and live auction items throughout the events. During the luncheon's silent auction, more than 100 vintage designer handbags went up for grabs, along with other fashionable items. Later in the day, there was another silent auction for the golfers, which featured an autographed, blown-up photograph of “The Shot” Ray made that helped the Miami HEAT win its third NBA Championship, along with other priceless signed sports memorabilia.

Three one-piece, limited-edition Hublot watches, the sneakers Ray wore during the 2013 NBA Finals, and other Ray Allen-signed memorabilia were among the highly-coveted items claimed at top dollar during the live auction, for which Ray served as auctioneer with comedian and writer Chris Spencer, while Ray’s mother, Flora, modeled and displayed the items.

“We had the opportunity to tour the Diabetes Research Institute last week, and we saw what they do first hand. They are the ones that we really rely on. When we talk about finding a cure, they are the ones who are in the lab every single day really making it happen,” said Ray during 2

The Allen family, including sons Wystan, Wynn, and Rayray and daughter Tierra, is committed to helping support critical research to find a cure for Walker. Likewise, the Holtz family has raised nearly $2 million for the cure-focused work of the Diabetes Research Institute with their previously held events. Their son, Andrew, now 19, was diagnosed with type 1 diabetes just after his 7th birthday. His older siblings, Matthew and Nicole, have always been involved in the family's fundraising efforts, and the events are extremely well-supported by their family, friends, and colleagues.

During the program, Andrew addressed the audience with a heartfelt speech. “The fact that you are all here for me and Walker is really just amazing. And I feel so lucky to have you all in my life,” he said. “I was 7 years old when I was diagnosed with diabetes and I had no idea what it all meant. And Walker is 7 years old, but he's been living with this since he was a baby and look at him, he's the happiest kid in the room.

He reminds me a lot of myself when I was that age. He really is such an inspiration to me, and to all of us.”

Special thanks are extended to everyone who helped make this event possible, including event sponsors: Presenting Sponsor Hublot; Gold Sponsor The Holtz Family; Dinner Sponsor Maria & Sheldon Lowe and Family; Sterling Sponsors Balogh Family Foundation, Wayne and Arlene Chaplin, Michel & Lauren Deller, Marquis Bank, Miami HEAT, Dr. Brigitt Rok and Mr. Alan Potamkin, Ray of Hope Foundation, Wells Fargo Advisors, LLC; Bronze Sponsors Brodson Construction, Hilary and Richard Cooper, Inserra Shop-Rite Supermarkets, Morrison Brown Argiz & Farra LLC; FJ Pollak, Tracfone; Stearns Weaver Miller Weissler Alhadeff & Sitterson, P.A.; Diamond Sponsors Micky and Madeleine Arison Family Foundation, Lisa and David Desmond, Janie Kupferman; Beverage Sponsor Southern Wine & Spirits; Goody Bag Sponsor Air Jordan; and Golf Shirt Sponsor Perry Ellis.

1) From left to right, Back row: Matthew Holtz, Nicole Holtz, Andrew Holtz, Javier Holtz, Andria Holtz, Shannon Allen, Ray Allen, Wystan Allen; Front Row: Wynn, Walker, and Rayray Allen.

2) Miami HEAT’s Chris “Birdman” Andersen and DRI COO Mitra Zehtab.

3) Diabetes Research Institute (DRI) supporters and colleagues: Manager of Donor Relations Aimee Siegel-Harris, NE Region Board member Lindsey Inserra, National Board member Bonnie Inserra, DRI Foundation CEO Joshua Rednik, Sr. Development Director Gary A. Kleiman, DRI Director Dr. Camillo Ricordi, National Board member Sheldon L. Singer.

4) Walker Allen poses with Maria Fernanda Alvarez and Tatiana Botero, who all have type 1 diabetes.

5) LeBron James and Local 10 Anchor Laurie Jennings.

3

4

5

EVENTS Empire Ball More than 900 guests gathered for the 30th annual Empire Ball, the signature event of the DRI Foundation’s Real Estate Division, on December 11 at New York's Grand Hyatt Hotel.

Guests enjoyed a lavish cocktail reception, followed by a bountiful dinner and an informative, humorous, and poignant program kicked off by Ball Chairman Peter L. DiCapua, chairman of CodeGreen Solutions. During its 30-year span, more than $32 million has been raised for diabetes research – with this year’s gala bringing in more than $1.3 million, including an overwhelmingly generous anonymous gift of $100,000. Pictured with special guest sports commentator Boomer Esiason (second from left) and DRI Scientific Director Dr. Camillo Ricordi (center) are Honorees Andrew Cooke, Jay Badame, and Joe Dussich.

Long Island Holiday Reception Holiday cheer was in abundance at the Long Island Holiday Reception, hosted by Roberta (left) and Bruce Waller at Muttontown Club on December 12. Among the 70 special guests in attendance were Fran and Howard Helfant, Rina and Jerry Weinbrom, Eric and Maria Reeps, Joan and Bill Fishlinger, and Wendy Waller, who were all presented with Cycle of Discovery Awards for their generous contributions and support of the DRI. Also honored was Allan L. Pashcow, who has been involved with the DRI for more than 20 years and recently ended his term of office as chairman of the regional board. Pictured are Roberta, Dara Melnick, and Wendy.

A Gift of Love…A Gift of Hope Luncheon The ladies at the Palm Beach Auxiliary raised more than $112,000 for the DRI at their 15th Annual A Gift of Love…A Gift of Hope Luncheon, which was held at the Polo Club of Boca Raton February 10. Event Chairwomen (l-r) Gloria Katz, Renee Aronin, and Natalie Olstein welcomed 270 ladies to the sold-out luncheon, where they treated them to an afternoon of private boutique shopping, card games, and raffles.

They also heard from 15-year-old speaker Brooke Miller, who has type 1 diabetes, and DRIF COO Deborah Chodrow – who made a special announcement that a portion of the proceeds of the event would go toward a critical piece of research equipment to be used at the DRI, in memory of Seth Aronin, the late son of event co-founder and chairwoman Renee and her husband, Arven Aronin. Seth had type 1 diabetes. A plaque was placed on the Equipment Wall at the DRI to pay tribute to his memory. To date, the Palm Beach County Auxiliary has raised nearly $600,000 for the DRI since its founding in 1998.

40th Anniversary Love and Hope Ball Hot off the heels of his “Saturday Night Live” cameo and U.S. media tour, music legend Barry Gibb performed an exclusive concert for a sold-out crowd of nearly 800 people at the 40th Anniversary Love and Hope Ball, held at the Westin Diplomat Resort & Spa in Hollywood on February 15. The black-tie gala – combined with November’s Preview Party – helped raise nearly $1 million this year, and was held in honor of Life Chairman Sonja Zuckerman, who has been at the helm of Love and Hope for all 40 years.

Executive Chairman Sandra Levy (standing) and DRI Director Dr. Camillo Ricordi were also recognized for their unwavering commitment to the DRI. Mistress of Ceremonies Belkys Nerey, Emmy Awardwinning journalist and anchor of WSVN News, thanked event honorees: Honorary Chairman Shirley Harris (seated), Anniversary Honorees Janie and Ronald Kupferman, Love Honorees Barbara and Norman Shapiro, Hope Honorees Mercedes and David Carlson, Ruby Star Honorees Sandy and Senator Paul Steinberg and Gold Star Honoree Sheila Wohl, as well as National Chairman Kathy Simkins. Event sponsors The GEO Group, Global Trend Alert, Landmark Trust, Neiman Marcus, Perfect Vodka, Margarita and Rick Tonkinson, and Saks Fifth Avenue were also recognized.

17 |

EVENTS Out of the Kitchen A crowd of 240 tapped into their inner foodies at Out of the Kitchen at the St. Regis Bal Harbour Resort on March 13 – and helped raise more than $155,000. At this unique affair, 20 chefs performed their craft tableside for tables of 12 diners – which included Miami HEAT’s Ray Allen and his wife, Shannon, CBS Miami Entertainment Reporter Lisa Petrillo, WPLG Local 10 News Anchor Laurie Jennings, and Comedian Chris Spencer, who acted as event MC. The event was co-chaired by (l-r) Steve and Tammy Klein, Amy and Scott Greenwald, St. Regis Executive Chef Tom Parlo, Executive Pastry Chef Antonio Bachour, and Chef de Cuisine for J & G Grill Brad Kilgore. The list of hot chefs included: Top Chef Finalist Nina Compton, Timon Ballo, Gabriela Machado, Conor Hanlon, Cesar Zapata, Marc Vidal, Michael Corvino, Giorgio Grapicavoli, Makoto, Dena Marino, Sean Brasel, Andrea Curto-Randazzo, Aaron Brooks, Todd Erickson, Carlos Brescia, Jeremiah Bullfrog, and Dave Hackett.

Cooking for a Cure It was a sizzling 11th Annual Cooking for a Cure – with more than $9,000 raised. Nassau County Legislator and DRIF Board Member Delia DeRiggi-Whitton (right) led the committee to create another fabulous evening at Page One Restaurant, Glen Cove, on Monday, April 7. This year, the event honored Dr. Francesco J. Caputo (second from left) of Caputo Chiropractic. He is a personal trainer/ fitness, nutritional counselor and motivational speaker who has authored and published the children’s book Diana the Organic Banana. Also pictured are DRIF’s Northeast Region Director Tony Childs (left) and Chef Jeanine DiMenna.

Kids’ Carnival for a Cure Families from all over the tri-state area came together for the annual Kids' Carnival for a Cure, which took place at Dave and Buster’s at the Mall at The Source in Westbury, March 16. Leading the event were Kids’ Carnival Co-chairs Sheri Donaldson, Lauren and Steven Field, Frankie Lam and Susan Rubinstein – who welcomed the attendees, including special guest, Disney star Dylan Riley Snyder (center), who plays the role of “Milton” on the hit series, Kickin' It. Kids and parents enjoyed a day of food and drinks, goody bags, playing video and arcade games, jumping on inflatables, bowling, playing pool and more. There were also raffles and a silent auction, which helped raise more than $128,000. (Pictured l-r: DRIF’s Josh Rednik, Aaron Field, Matthew Donaldson and DRIF’s Tony Childs.

The Crystal Ball More than 300 guests, including daytime television royalty Susan Lucci and world renowned author Nelson DeMille, helped raise more than $728,000 at the 15th annual Crystal Ball, held May 3 at The Garden City Hotel in Long Island. DRI Foundation NE Region Co-chairman Bruce Siegel served as Master of Ceremonies, Allan L. Pashcow received the Gillin Family Humanitarian Award, and Frank Pusinell, RA, EVP of operations, property management and construction, RXR Realty, was honored with the Distinguished Service Award. Formerly referred to as the Crystal Ball Honoree, this year’s award was renamed the Rowland and Sylvia Schaefer Award, in memory of a couple who helped advance the DRI’s research. The award was presented by the Schaefers' daughter and son-in-law Roberta and Bruce Waller to Dr. Camillo Ricordi via video. Bruce co-chaired the event along with his sister, Wendy Waller. (Pictured l-r: Allan and Louise Pashcow, Susan Lucci, Helmut Huber, Sandy and Nelson DeMille).

D.R.E.a.M.S. in the city The Ninth Annual D.R.E.a.M.S. in the city took place on Tuesday, May 6th, at The Pierre in NYC. Nearly 300 people feted the evening’s honorees, Irene and Sy Cohen and Diane and Robert Cohen, who received the “Dare to Dream” award; and Dr. Jason C. Baker, who received the Humanitarian award. The festivities raised more than $550,000. Longtime co-chairs and sponsors were Samantha Shanken Baker, Bonnie Inserra, and Meryl Lieberman. The 50-Carat Presenting Sponsor was The Inserra Family. Platinum Sponsors were the Cohen Family Foundation, Shanken Family Foundation, and Stacy Joy Goodman Memorial Foundation. Alan Kalter of Late Show with David Letterman served as MC, while the Jay Prince Band played an amazing musical set.

Vince Wilfork Draft Fundraiser Vince Wilfork (right), defensive tackle for the New England Patriots, held his 11th annual draft night fundraiser at Pinz Entertainment in Milford, MA, this past May. The event that he and his wife, Bianca (center), organize each year was well attended and raised funds for the DRI and Joslin Diabetes Center in Boston. His efforts are in memory of his father who passed away from diabetes-related complications.

Pictured with the Wilforks is DRIF VP Tom Karlya.

Don Strock Diabetes Golf Classic The 31st Annual Don Strock Diabetes Golf Classic presented by the Miami Seaquarium drove in nearly $125,000 on May 14 – crossing the $2.5 million mark in overall funds raised to date.

Tournament Host Don Strock (far right) and Chairman Bruce Fishbein (second from left) of The Produce Connection, saw another strong show of support from more than 140 celebrity and amateur golfers, which included alumni, NFL pros, and radio personalities, such as John “Footy” Kross, Scott “Froggy” Langley, Charles Bennett, Eddie Hill, Kerry Glenn, Stephen Potter, Roy Barker, Pat Dennis, John Harris, and Quadtrine Hill. They played an 18-hole tournament, followed by a cocktail hour and an awards dinner, live and silent auctions and a moving speech by Arianna Lamosa, who was joined onstage by her 6-year-old daughter, Olivia, who has type 1 diabetes. Also pictured with Strock and Fishbein are Fishbein’s grandson Isaiah (right) and Arthur Hertz (center) of Miami Seaquarium with characters from the family attraction.

Brenda Novak’s Online Auction for Diabetes Research It was a record year for the Brenda Novak Online Auction for Diabetes Research, with more than $370,000 in funds raised through auction items and a special edition A Sweet Life Boxed Set sales. Created by New York Times and USA Today Bestselling Author Brenda Novak 10 years ago in honor of her 17-year-old son, Thad, who has type 1 diabetes, the auction has raised a whopping $2 million plus for diabetes research. This year, exclusive items included Celine Dion “meet and greet” and concert tickets, signed books by fellow bestselling authors, and hundreds more. But the hot item of the auction was the A Sweet Life anthology – which Novak created with the help of 13 fellow authors and sold exclusively to benefit the auction.

Shell Key West Challenge Nearly $500,000 was raised at the 25th Annual Shell Key West Fishing Challenge this year thanks to the participation of hundreds of fishermen, Shell employees, wholesalers and corporate sponsors. DRI COO Dr. Mitra Zehtab was one of the guest speakers at the three-day, deep-sea fishing competition – which took place April 24-27 on the beautiful waters surrounding Key West. The event, started by Jo and Hayden Blaylock, founder and CEO of Blaylock Oil Company, and continued today by daughter Crystal Blaylock Sanchez, began benefiting the DRI after Crystal’s son, Matthew Sanchez (center), was diagnosed with T1D. Also pictured with the Blaylocks are event sponsor (l-r) Paul Stanifer, Motiva Enterprises general manager of fuel sales and marketing; Dan Romasko, Motiva Enterprises.

Sportsmen for Charity Sportsmen for Charity saw yet another successful sold-out year at the picturesque Pawling Mountain Club in Pawling, NY, on April 25. Participants enjoyed delectable food, practice rounds, a friendly sportsmen competition and cocktail hour with the stunning Appalachian Trail National Park as the backdrop. Pictured are DRI Foundation Northeast Region Director Tony Childs (l) presenting Event Chair Charles Guigno (r) with a Realization Award for his dedication to the DRI every year.

19 |

DRIfocus

Non-Profit Org. US Postage PAID Diabetes Research Institute Foundation

Diabetes Research Institute Foundation National Office 200 South Park Road Suite 100 Hollywood, FL 33021 address service requested

For information on the events or to make reservations, visit DiabetesResearch.org or call one of the DRI Foundation offices listed below.

CALENDAR Fishing for a Cure August 2014 / MICHIGAN This local fishing tournament, held on Kent Lake in Kensington Metropark of Livingston County, MI, raises diabetes awareness and funds for the DRI. The Rod Gilbert DRI Golf Classic August 11, 2014 / LONG ISLAND To be held at the beautiful Pine Hollow Country Club, this event will feature a fun day of golf, followed by an awards dinner and silent auction.

Haute Tea September 12, 2014 / FLORIDA The Young Society of Love and Hope will host the third annual event, featuring lunch, champagne, silent auction and prizes for the finest hats.

Cocktails for a Cure September 13, 2014 / NEW YORK

The Besner family and Willa's Wish Foundation host an evening of cocktails, hors d'oeuvres and dancing at the Hudson Terrace Salon.

Gold Coast Concours/Bimmerstock September 14, 2014 / LONG ISLAND Hundreds of exotic cars and BMWs will be showcased throughout the day at this magnificent exhibit, to be held at the City of Glen Cove’s downtown.

Phil Peterson’s Key West Poker Run September 19 - 22, 2014 / FLORIDA Phil Peterson will host his annual motorcycle run, which starts in Miami and finishes in Key West for South Florida’s biggest biker party weekend of the year.

a golf outing at Winged Foot Golf Course in Mamaroneck, NY. Enjoy a full day of golf, plus a hearty breakfast and lunch, followed by a cocktail reception and dinner.

All In for a Cure November 4, 2014 / NEW YORK To be held at the Grand Havana Room, the seventh annual Texas Hold’em tournament will feature a silent auction, fine wines and spirits, exclusive cigars, hors d’oeuvres and a dinner buffet.

Fall Into Fashion November 6, 2014 / LONG ISLAND To be held at the Garden City Hotel, this event will highlight the upcoming season’s best fashions during a splendid lunch with a “chance” auction and more.

The Donaldson Organization Golf Outing Love and Hope Preview Party October 6, 2014 / NEW YORK November 7, 2014 / FLORIDA The Donaldson Organization will host Kick off the celebration with us at the

DRIfocus

is a publication of the Diabetes Research Institute Foundation.

Summer 2014/ Volume 41 / Issue 2

Marketing & Communications Dept.

Lori Weintraub, APR Lauren Schreier Joelle Parra Laurie Cummings

Contributors Gary Kleiman Glenn Kleiman Melissa Pena Jill Salter Aimee Siegel-Harris Mitra Zehtab, M.D.

Photography DRI / DRIF staff and volunteers Gabriela Bianchini Marc S. Levine Photography Joe Marzo Photography Andrew Milne Photography Donna Victor Design Franz Franc Design Group Inc.

event long-ago dubbed the "heart of Love and Hope." To be held at the St. Regis Bal Harbour Resort, the evening will begin with a fabulous cocktail reception and continue in the ballroom with dinner and dancing.

Empire Ball December 10 2014 / NEW YORK A veritable Who’s Who of New York’s real estate giants, this annual black-tie dinner dance is the industry’s social event of the season, to be held at the Grand Hyatt Hotel.

Champions for Charity December 2014 / LONG ISLAND This annual holiday shopping benefit is designed to raise funds for not-for-profit organizations. Twenty five percent of sales will be donated to the DRI when supporters use a Champions for Charity Card. Shop, shop, shop!

The Diabetes Research Institute Foundation supports the Diabetes Research Institute at the University of Miami Leonard M. Miller School of Medicine, whose mission is to develop and rapidly apply the most promising research to treat and cure those now living with diabetes. To obtain additional information or request copies of DRIfocus, please call (800) 321-3437 or e-mail lweintraub@drif.org, or visit DiabetesResearch.org.

DIABETES RESEARCH INSTITUTE FOUNDATION National Office / Florida Region 200 South Park Road, Suite 100 Hollywood, FL 33021 Phone: (954) 964-4040 Fax: (954) 964-7036 info@drif.org

Northeast Region / Manhattan Office 381 Park Avenue South, Suite 1118 New York, NY 10016 Phone: (212) 888-2217 Fax: (212) 888-2219 neregion@drif.org

Northeast Region / Jericho Office 410 Jericho Turnpike, Suite 201 Jericho, NY 11753 Phone: (516) 822-1700 Fax: (516) 822-3570 neregion@drif.org