DRIfocus Newsletter June 2013

Diabetes Research Institute Foundation

DRIfocus

June 2013 / Volume 40 / Issue 2

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At the DRI and Foundation, our mission is to discover a biological cure for diabetes – to restore natural insulin production and normalize blood sugar levels without imposing other risks.

DRI scientists have been making steady progress toward this goal and, in early March, unveiled the DRI BioHub, a bioengineered “mini organ” that mimics the native pancreas, containing thousands of insulin-producing cells that can sense blood sugar and release the precise amount of insulin needed - in real time.

the need for anti-rejection drugs that patients must take for life, the eventual need for a plentiful supply of insulin-producing cells The DRI’s research focus has always been on for transplant, and the identification of an curing diabetes by replacing the insulin- optimal site within the body to house the new producing islets cells that have been mistakenly cells. The BioHub is a platform that addresses destroyed by the immune system in those these challenges by drawing on recent with type 1 diabetes. Clinical trials have developments in bioengineering, immunology, already shown that people with long-standing and decades of transplantation expertise. diabetes can achieve insulin independence Prior to their destruction by the immune after receiving infusions of islet cells from a system in type 1 diabetes, healthy islets thrive donor organ. Some study patients continue inside the pancreas, where they have to be insulin free for more than a decade sufficient oxygen, adequate space, and all the post transplant. nutrients needed to perform the demanding However, islet transplantation has been limited job of normalizing blood sugar levels. The to only the most severe cases of diabetes; BioHub attempts to closely replicate the cells’ several challenges still remain before the natural environment and allows scientists to strategy can be offered to all who can benefit. fine tune these cellular needs within the The existing hurdles to be overcome include transplant site as never before.

“The progress in islet transplantation has been incremental and has allowed us to get to this important juncture. The DRI BioHub gives us a tool to combine all we’ve learned through the years of clinical testing and take the next leap forward. I am confident that this approach could move cellular therapies and biological replacement strategies for the cure of diabetes to our final goal,” says Camillo Ricordi, M.D., Stacy Joy Goodman professor of surgery and director of the Diabetes Research Institute (read "Under the Microscope with Dr. Ricordi" on page 10).

Among the platforms being tested for a DRI BioHub is a porous, sponge-like material approximately the size of a quarter that is compatible with the human body. Islet cells are gently seeded on this protective platform, allowing cells to nestle within the individual pores.

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Pearlman Steps Down

In Memoriam

DRI BioHub Gifts

Walk with Walgreens

After 20 years, DRIF President and CEO Robert A. Pearlman stepped down effective June 30.

The DRI family is deeply saddened by the passing of dear friends and longtime supporters Sylvia and Rowland Schaefer.

Several generous donors like Hon. Maryanne Trump Barry (with her grandson, Robert Desmond) have made significant gifts to support the DRI BioHub initiative.

Thousands walked and raised more than $400,000. On site were celebs like Nat Moore, Chris Conlin and Bobby Harden of the Miami Dolphins.

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A Message

from the Chairman Dear Friends, As we reach the end of this fiscal year, we head into the new one with heightened optimism about the possibilities ahead. Just a few months ago we unveiled the DRI BioHub mini organ, one of the most exciting initiatives yet on our path to discovering a biological cure for diabetes. As you read in the cover story, the BioHub builds on decades of progress in islet transplantation and harnesses new advances in science to restore natural insulin production in millions with diabetes.

with us. Sylvia and Rowland Schaefer were among the organization’s most generous contributors and their kindness and friendship will long live in our hearts. It is in the building that bears their name that our DRI investigators conduct their cutting-edge work to find a cure – the Schaefers' ultimate goal for their granddaughter and millions of others.

Though we are moving ahead with great momentum and enthusiasm, we are doing so without the leadership of Bob Pearlman, who stepped down from his position as president and CEO (article follows). Bob has been at the helm of the DRIF for almost 20 years and his expertise, experience and commitment have taken the organization to new heights. We are grateful for his dedication over these last two decades and he will be deeply missed.

DRI researchers are working aggressively to make the BioHub a reality, uniting with collaborators worldwide to overcome barriers to progress. Together, they are simultaneously testing several components of the BioHub in order to eliminate unnecessary delays. In his “Under the Microscope” interview (page 10), DRI Director Dr. Camillo Ricordi provides a status of these technoloWe will continue to count on all of you, together with our board members, gies and how they will all come together in a series of clinical trials.

DRI scientists and Foundation professional staff, to accomplish great things Certain to impact this timeline are the financial resources available to move for those living with diabetes. Thank you again for all that you do this groundbreaking work forward. Our researchers continue to rely on the to support our cure-focused mission. generosity of people like you, who make this progress possible. We are grateSincerely, ful for the extraordinary support we’ve received from many contributors, like those highlighted in this issue, who have made significant gifts, hosted receptions, spearheaded events and conducted other activities to help further our critical research.

Harold G. Doran, Jr. As we celebrate the generosity of these many individuals and families, we Chairman of the Board also pay tribute to two special members of our DRI family who are no longer

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1. Robert A. Pearlman 2. Deborah Chodrow

DRIF PRESIDENT AND CEO ROBERT A. PEARLMAN STEPS DOWN AFTER 20 YEARS After successfully leading the Diabetes Research Institute Foundation for two decades, Robert A. Pearlman stepped down from his position as president and CEO effective June 30, 2013.

Bob was recruited to the DRI Foundation in 1993, after a 25-year career in the fundraising field, to increase funding for the Diabetes Research Institute.

During his tenure, the Foundation and the DRI experienced exponential growth, developing into one of the premier diabetes organizations and a recognized world leader in cure-focused diabetes research.

Under his leadership, the DRIF has raised approximately $300 million and, in the process, became the largest contributor to the University of Miami in its history. Bob presided over three consecutive five-year campaigns, which increased fundraising substantially. When Mr. Pearlman stepped down at the end of this fiscal year, the annual campaign closed 13 percent over this year’s goal and up 34 percent over last year.

“We thank and honor Bob for his tremendous service for the last 20 years. He built the Diabetes Research Institute and Foundation into a world-class institution and has made a tremendous impact on shortening our timeline toward the discovery of a cure for diabetes,” said Harold G. Doran, Jr., chairman of the DRIF’s National Board of Directors.

“Bob is leaving us in a strong and exciting position to move toward our goal of a cure and continue our momentum after unveiling the DRI BioHub earlier this year.”

DRI Foundation Chief Operating Officer Deborah Chodrow became acting president and CEO on July 1, 2013. She will serve in this capacity as the organization conducts a national search for a permanent successor. Bob will remain a consultant to the Foundation for a period of time to ensure a smooth transition for his successor.

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NEW LEADERSHIP TO HEAD FOUNDATION’S

NEW NORTHEAST REGION 1

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With the components that comprise the DRI BioHub in various stages of development and testing, it is more critical than ever for the DRI Foundation to raise the funds necessary to support this platform. Beyond Florida, the offices in New York City and Long Island have always been integral to the Foundation’s success. Moving forward, the two offices will work even more closely together as the two regions have been consolidated into the new Northeast Region, as approved by the DRIF’s Executive Committee.

Critical to the success of this consolidation is the establishment of a new leadership structure for the region. William J. Fishlinger and Marc S. Goodman have been appointed to serve as Northeast Region co-chairmen. Bill and Marc have both been active and solid leaders with the DRI Foundation on the regional and national levels, and their continuing guidance will be pivotal to the region’s future success.

Since 2008, Anthony E. Childs has effectively led the Long Island Region, while attracting new donors and increasing financial support for the Institute. Now, Tony has been appointed to head the Northeast Region, which includes both the Manhattan office and the Jericho office.

“I’ve been building relationships with several of our longstanding supporters and board members in the New York City area and beyond, and I look forward to widening our reach throughout the Northeast,” said Tony, a seasoned fundraising professional who holds a master’s degree in nonprofit management. He has formerly held leadership positions with American Cancer Society, St. Catherine of Siena Medical Center, and the Interfaith Nutrition Network.

1. William J. Fishlinger 2. Marc S. Goodman 3. Anthony E. Childs 4. Allan L. Pashcow

“During my tenure here at the DRI Foundation, I’ve met so many wonderful families who are affected by diabetes. There’s nothing that would make me happier than to know that our combined efforts will help find a cure for these amazing individuals and the millions of people affected by diabetes around the world,” he said.

Special thanks are extended to outgoing Long Island Region Chairman Allan L. Pashcow, who has done a remarkable job in leading the Long Island Region over the past six years.

IN MEMORY OF SYLVIA AND ROWLAND SCHAEFER All of us at the Diabetes Research Institute and Foundation are deeply saddened over the passing of dear friends, Sylvia and Rowland Schaefer, who passed away just days apart from each other. Rowland and Sylvia will forever be remembered as two of the organization’s most longstanding and generous donors.

Over the last 40 years, Sylvia and Rowland have committed more than $11 million to the DRI. In recognition of their generosity and leadership, the building at the University of Miami Miller School of Medicine housing the Diabetes Research Institute bears their name.

The Schaefers became involved with the DRI Foundation after their granddaughter, Dara Kriss-Melnick, was diagnosed with type 1 diabetes in 1989. Dara is the daughter of DRI supporters and Long Island Region Board Members Roberta and Bruce Waller. Bruce also serves on the DRI Foundation's National Board of Directors.

Rowland was a nimble entrepreneurial innovator, who used various businesses he founded as stepping stones to the development of other businesses, most notably Claire’s Stores, Inc., a worldwide fashion accessory powerhouse. Today, there are over 3,000 stores located throughout North America, the UK, Europe, Japan, Russia, Poland, the Middle East and South Africa. Claire’s Stores had been a NYSE listed company traded under the symbol CLE, with sales that exceeded $1 billion a year and a market capitalization of $2.5 billion. The Schaefer family sold the business to a private equity firm in 2007.

May marked Sylvia and Rowland’s 65th wedding anniversary. Sylvia passed away on May 26 at the age of 89. Rowland followed her on May 29 at age 96. They will forever remain in our hearts.

Sylvia, once a fashion model, wrote a column in Good Housekeeping magazine called “Sylvia Says.” She raised three daughters of her own as well as a son and daughter from Rowland’s first marriage. She was a creative force behind the family business and a member of the DRI Foundation’s Love and Hope Committee.

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SIGNIFICANT SUPPORT FOR THE DRI BIOHUB ABOUNDS Now that the Diabetes Research Institute is taking a monumental step forward in the discovery of a biological cure for diabetes, it’s time to take a closer look at what’s going to get us around the final bend.

When the Institute and Foundation unveiled the DRI BioHub, several passionately committed individuals and organizations made substantial gifts toward the effort, and they’re hoping an army of supporters will follow their lead.

One of the critical hurdles to overcome in the development of a DRI BioHub is the limited supply of transplantable islet cells. After learning about the initiative, the trustees of the Fred and Mabel R. Parks Foundation announced a $2 million commitment to establish the Fred and Mabel R. Parks Cell Supply Center at the DRI. The Center is charged with developing an infinite supply of insulin-producing cells to be housed inside the DRI BioHub, a bioengineered mini organ that will normalize blood sugar levels.

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“When the other trustees and I learned about the DRI BioHub, we found it very compelling. To think that the cure for diabetes could be discovered right here at the University of Miami…we felt it was the right time to make a major commitment to advance this research.”

The Honorable Maryanne Trump Barry, a senior judge on the United States Court of Appeals for the Third Circuit, has bolstered the effort with a $1 million contribution. Maryanne is the mother of David Desmond, who along with his wife, Lisa, hosted a lovely reception at their Palm Beach home for an intimate group of supporters and scientists.

After the DRI BioHub was presented to the group, Maryanne stood to make a heartfelt announcement.

“I don’t normally do this kind of thing,” Maryanne said with a smile as she retold the story of the day she got the news that her grandson, Robert Desmond, had been diagnosed with type 1 diabetes. “Robert called me from his hospital room and said, ‘Good things can come from bad situations.’ Not only was I genuinely touched by his strength, his courage, and his selfless attempt to comfort me, but I knew he was right. And that’s why, today, I would like to make a gift in the amount of $1 million to the Diabetes Research Institute toward the cure for diabetes. I believe the DRI BioHub could be the answer we’ve all been waiting for.”

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“We wanted to be a major part of the cure,” stated Jim McClellan, president of the Parks Foundation and one of the organization’s four trustees. “After I took a tour of the Diabetes Research Institute, I was impressed not only by the people working there but also because it is solely focused on a cure. And that’s our motivation – to find the cure.”

“I’ve done a lot of research, and there are many organizations that say they are cure-focused but don’t actually spend their money that way.

For me, a light went off after learning about the DRI BioHub. I have confidence that this research could lead to the cure,” said McClellan.

When talking about medical research in South Florida, one name in particular always comes to mind – George E. Batchelor. He was an aviation entrepreneur and a philanthropist who gave millions of dollars for research on children’s health, as well as a number of other worthy causes. His vision lives on through The Batchelor Foundation, which has recently made a $1 million contribution toward the DRI BioHub. “We like to focus support on organizations within our community,” said Jon Batchelor, vice president of The Batchelor Foundation.

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Similar to the evening at Lisa and David’s home, small, private receptions were hosted in Manhattan, Long Island and Miami so that DRI scientists could personally present the vision and strategy behind the development of the DRI BioHub. National Board member Bonnie Inserra and Larry Inserra generously underwrote an informative evening at the Academy Theater at Lighthouse International in New York City. Veronica and Rodrigo Alvarez and Uchi and Juan Carlos Botero hosted an event at the Grand Bay Club in Key Biscayne, where the reception room overflowed with supporters. The two families hope to see a cure for their young daughters, Maria Fernanda Alvarez and Tatiana Botero.

“I’m not a doctor or a scientist, but I trust those working at the Diabetes Research Institute implicitly,” said Ricardo Puente, who attended the Key Biscayne reception. His mother, Martha Puente, has been working at the DRI since 1972 and is a senior accountant.

“I grew up listening to my mom talk about the commitment and the drive of these researchers. There’s a strong level of trust that has been built. So when I learned about the DRI BioHub and what this could

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THE DRI BIOHUB

Continued from cover.

Researchers are also testing the use of more natural containers, such as a patient’s own vein, that can be tied off to create a “venous sac” complete with its own pre-existing vascular supply. In addition to housing transplanted insulin-producing cells, a DRI BioHub will also allow scientists to enhance the immediate transplant environment with additional oxygen, specific types of “helper” cells or other agents to promote the cells’ long-term survival and function.

Additionally, a BioHub platform can be used to house not just islets, but any future insulinproducing cell type that scientists create.

TUNE IN TO DRI TV If you want to keep up with the latest progress on the DRI BioHub and other promising research breakthroughs as they happen, then tune in to DRI tv right on our website at DiabetesResearch.org /DRItv. Join DRI tv host Benno Schmidt, an award-winning and well-known television journalist and producer who has type 1 diabetes, for a first-hand look at the latest from the labs. The new episode focuses on a key part of the DRI BioHub the scaffold platform - developed by Dr. Cherie Stabler and her team.

“The development of a mini organ would mimic the native pancreas and restore the natural metabolic function of insulin release in immediate response to blood sugar levels-something currently unavailable to patients with diabetes,” said Jay Skyler, M.D., deputy director of clinical research and academic programs at the DRI. “If we can identify an optimal place within the body to place a BioHub, then I believe this disease is totally reversible, which has been the DRI’s ultimate goal since our inception,” adds Luca Inverardi, M.D., deputy director of translational research.

The components that comprise the BioHub are in various stages of development and testing, with pre-clinical trials currently underway. In addition to critical support from philanthropy, research on the DRI BioHub platform is also funded by numerous sources, including but not limited to the Diabetes Research Institute Foundation, JDRF, The Leona M. and Harry B. Helmsley Charitable Trust, National Institutes of Health, NIH Small Business Innovation Research (SBIR), University of Miami, pharmaceutical companies, both foreign and domestic, and additional corporate and philanthropic partners. To learn more about the DRI BioHub and to view the video, visit www.DiabetesResearch.org/BioHub.

The scaffold, which can house thousands of insulin-producing cells and other components, used to be made by hand.

Now, the researchers have a new, one-ofa-kind machine called a “compression molder” that can scale up production of the scaffold and meet the consistent quality standards required by the FDA for use in patients.

Institute scientists are developing a DRI BioHub, a bioengineered “mini organ” that mimics the native pancreas, containing thousands of insulin-producing cells that sense blood sugar levels and release the precise amount of insulin needed in real time. Components of the DRI BioHub are in different stages of testing, with firststage clinical pilot trials planned within the year.

mean to everyone living with diabetes, I wanted to support it,” said Rick, who made a $500,000 gift to the DRI, via the Ricardo Puente Family Foundation.

Following the unveiling, the excitement surrounding the DRI BioHub was palpable. The diabetes community responded with enthusiastic feedback and a host of questions. In order to give people a better view, a webcast was organized, attracting participants from around the world. The one-hour presentation can be viewed on demand, and the follow up Q&A can be accessed on our website at: DiabetesResearch.org/BioHub-Webcast

Learn more about the scaffold platform, one of the first components to be tested in pilot clinical trials, and the man behind the machine in the latest episode of DRI tv.

1. Jim McClellan, president of the Fred and Mabel R. Parks Foundation 2. George E. Batchelor 3. Robert A. Pearlman, DRI’s Drs. Chris Fraker and Camillo Ricordi, Lisa, Robert and David Desmond, Hon. Maryanne Trump Barry, DRIF Chairman Harold Doran and Kellie Doran 4. Ricardo Puente and his mother, Martha Puente 5. Larry Inserra, National Board member Bonnie Inserra and Dr. Camillo Ricordi 6. Allan L. Pashcow, Ann Doscas, John Doscas and Harold Doran 7. Robert A. Pearlman, Juan Carlos and Uchi Botero, Natalia Botero, Dr. Ricordi, Tatiana Botero, Maria Fernanda Alvarez, Veronica and Rodrigo Alvarez, Rodrigo Alvarez, and DRI’s Cherie Stabler, Ph.D.

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The individuals and organizations mentioned in this article and so many others have already made an indelible mark in the world of diabetes. Their generosity, coupled with the acumen of the DRI’s multi-disciplinary team of scientists, has helped us rise to this point.

We hope you will stand with all of us at the Diabetes Research Institute and Foundation as we make that next leap toward reaching the biological cure.

Together, we can end diabetes forever.

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FOUNDATION DONORS RECOGNIZED Awards from the DRI Foundation’s Cycle of Discovery series were presented to donors who recently made major gifts. The award program corresponds with the Foundation’s cumulative giving designations. Awards were presented individually, at Foundation events and at a lovely reception for the Empire Ball contributors held at The Durst Organization in New York City.

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PERPETUATION AWARD: DRI’s Scientific Director Dr. Camillo Ricordi accepts with Robert A. Pearlman (1).

TRANSLATION AWARD: Isabel May (2).

REALIZATION AWARD: Sandra and Sid Levy (3).

EXPLORATION AWARD: Richard Imperatore of Brookbridge Consulting Services, Inc. (4), Steve LaSala, Jr. of Turner Interiors (5), Michele Medaglia of ACC Construction Corporation (6), Lillian Redlich accepts with DRIF’s Pearlman (7), Merryl and Joe Warner of The Simon Foundation (8).

HYPOTHESIS AWARD: DRIF’s Chief Operating Officer Deborah Chodrow accepts with DRIF’s Pearlman (9), Lola and Gus Efthimiou (10), Helene and Marc Kovens (11).

QUERY AWARD: Al Amore of Trinity Real Estate (12), Richard Veltri of United Air Conditioning with Chales Rizzo (13), Betty Madigan Brandt (14), Fred Horwood of Time Warner Inc. (15), Beverlee Shere accepts with DRIF’s Pearlman (16), Charles Balsamo and George DiStefano of Unity Construction Group (17).

DONOR LEVEL

AWARD

Visionaries Chairman’s Council Leadership Council Governors’ Society Distinguished Humanitarians Grand Founders Founders Benefactors

$10,000,000+ $5,000,000+ $1,000,000+ $500,000+

Innovation Validation Perpetuation Translation

$250,000+ $100,000+ $50,000+ $25,000+

Realization Exploration Hypothesis Query

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FOR FRIENDSHIP When he was a little boy, Jason Zuriff of New York was invited to Carnival for a Cure by Tyler Stern, a close friend whose sister has type 1 diabetes. Ever since then, Jason joined Tyler at the DRIF fundraiser annually, and for the past few years the pair even served as volunteers. Then, as his bar mitzvah approached, Jason saw the opportunity to do even more to show his support for his longtime friend’s family and the many others in the world touched by diabetes. In lieu of gifts, he asked loved ones to make a donation to the DRI in his honor. The total surpassed $11,000!

The money will be used to purchase a piece of equipment known as a Biological Safety Cabinet Hood. Dr. Alice Tomei, research assistant professor of surgery and cell transplantation at the DRI, and her staff will use it to maintain sterile conditions during research experiments. We’re touched by the spirit of this young man, whose actions reflect the power of friendship.

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FUNDING A MISSION BY

LEAVING A LEGACY “We’ve got to talk about it!” proclaimed Irene Cohen, her tone impassioned, her excitement infectious. In reference to the DRI BioHub, she explained, “It’s the latest, most promising discovery in science, and this is something that should be at the forefront of our conversations.”

“The DRI BioHub will be able to restore normal blood sugar levels,” she continued. “It’s a giant step forward for the Diabetes Research Institute.

Dr. Camillo Ricordi and the team have given us a tremendous feeling of hope, and that’s exactly why we needed to ensure that this progress continues.”

Irene and her husband, Sy Cohen, decided to provide for the DRI through their will in the form of a bequest, making them members of the DRI Heritage Society. Married 50 years and now retired, the couple spent decades in the outsourcing business, resulting naturally in a goal-oriented mindset. “We know the DRI is dedicated to the cure, and we’re funding a mission,” she said.

The Cohens’ daughter and Jake’s mom, Diane Cohen, is a member of the DRI Foundation’s Northeast Region Board of Directors. She served as cochair of the 2013 D.R.E.a.M.S. in the city and previously as a vice chair. Her husband, Robert Cohen, has participated in multiple bike rides to raise money and awareness for diabetes research. Sy and Irene have supported their personal fundraising endeavors, as well as attended the D.R.E.a.M.S. event for years, and they are Distinguished Humanitarians of the DRI Foundation. The entire family is truly tuned in to the diabetes community.

“We know all too well that insulin is not a cure; it’s simply the only treatment that we have at this time,” said Diane. “That’s simply not good enough. We will do everything that we can as a family to give Jake back a normal life. We absolutely believe that the DRI and the BioHub will provide that for Jake.”

Irene further explained, “We went to Miami for the tour, and it was absolutely mind-boggling! There was so much going on and with the DRI’s collaborations around the world; we knew that every dollar we gave would be multiplied in terms of research.”

Sy added, “I was struck by the dedication of the scientists, but what stuck in my mind was the cost of the equipment, the microscopes and machines. We need to fund this technology in order to make a difference.

It was eye-opening.”

Through the years, they’ve kept abreast of the extraordinary progress being made at the DRI, while continuing to be alarmed at the rising diabetes statistics. According to a recent study released by Diabetes Care, the incidence of type 1 diabetes in very young children under age 5 has increased by 70 percent, and the number of diagnosed cases among all kids up to age 14 rose by 29 percent. The study was conducted in Philadelphia over a span of two decades and similar increases have been seen across the U.S. and Europe.

Robert and Diane Cohen with Irene and Sy Cohen.

But it’s the Cohens’ personal mission that drives their commitment to the cure. Their grandson, Jake Cohen, was diagnosed with type 1 diabetes when he was a sophomore in high school, and although the family was initially devastated, they jumped right into researching the top cure-driven facilities. Once they found the Diabetes Research Institute and Foundation, they turned their focus to fundraising.

“The increasing statistics are staggering,” said Irene. “We simply have to eradicate it.”

Toward that end, the Cohens met with their estate-planning attorney in order to provide for the DRI through a bequest. “We do everything we can now, but we can do so much more in our wills. Jake is the future, and we’re investing in our future – by leaving a legacy,” she said.

To learn how you can invest in the DRI’s efforts to develop a biological cure for diabetes and leave a legacy, contact Jill Shapiro Miller, vice president of gift planning at 1.800.321.3437.

WALGREENS REACHES $1 MILLION MARK More than 6,500 South Floridians converged upon Sun Life Stadium in Miami Gardens, FL, for the Walk with Walgreens Family Fun Day and Health Fair on April 20. A second location, Tradition Square in Port St. Lucie, attracted hundreds more. Thanks to donations collected by teams, plus the generosity of corporate sponsors and the sales of "scannables" at Walgreens stores, this year's fundraising effort surpassed $400,000.

Cheers erupted upon DRIF VP Tom Karlya’s announcement that Walgreens Market 6 of Florida has reached $1 million in fundraising for the DRI in just three years. UM President Donna Shalala, DRI Scientific Director Dr. Camillo Ricordi, and DRIF President and CEO Robert A. Pearlman all shared their personal appreciation with the crowd, giving special mention to Walgreens Market VP Roy Ripak, and some of the hardworking members of his staff, including Clint Smethurst, Dan Espinosa, Georgia Lehoczky and Steve Flynn.

Joe Rose kicked off the MultiRace Keep Believin’ Half Marathon and 5K Run before recognizing top fundraisers, including: Team Jace led by Jennifer Tacher, Super O led by Arianna Lamosa, Team Julia led by Mike Soskin, Team Colby led by Sabrina Ferris and Shannon’s Spirit led by Valerie Ahmuty.

DIABETES DIPLOMATS: HEROES WITH HEART Diabetes Diplomats of all ages are raising funds for the DRI in many parts of the country and even around the world. Their projects are unique, but their goal is shared. How will YOU help the DRI move closer to a cure?

Email TomKarlya@DRIF.org today, and you too can Be the Hero!

Ardsley Middle School Eighth Graders Samantha Chong, Kruti Sutaria, Karen Jiang, Jared Smith and Jack Cassara, shown (l-r) with their teacher, Jeff Allese, won a business challenge in social studies class with their best-selling swag eyeglasses. Under the advice of Smith, whose grandfather passed away from complications of diabetes, they chose to donate the revenue from all of the projects from their New York classroom to the DRI. Siblings Jesse, Jake and Ally Rosenberg organized Spin for a Cure for the second year. This time their methods evolved from collecting donations by hand to creating a page on the DiabetesDiplomats.kintera.org website. Nearly three dozen supporters spun for a cure alongside them, including their proud parents, Greg (far left) and Denise Rosenberg (right.) Also pictured is Tania Marrero (far right), the class instructor.

Benefiting the DRI for the fifth year and appropriately held on Mother’s Day Weekend, the Blair County Diabetes Walk & Family Fun Day was founded by Lisa Treese and continues to be organized by her and other moms of kids with type 1 diabetes. What started with one family and

one school has grown to include the participation of three schools and 23 teams 23 families whose bond won’t be broken 4 and whose efforts raised $17,000! This year the funds coming to the DRI from Blair County, PA, nearly doubled with a consecutive event called Float for Charity. Nearly 650 people paddled ten miles, raising another $15,000!

A group of students at Scotland Elementary in CT decided to show their peers what it feels like to have type 1 diabetes in your life: mixed up! They organized a Crazy Dress Up Day to raise funds for the DRI and educated their schoolmates at an assembly. Pictured (l-r) with DRIF VP Tom Karlya and Principal Mark Solomon (far right): Jeffrey, Max, James, Sarah, Julia and Patrick, students with type 1 diabetes and some of their siblings.

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1. Ardsley Middle School 2. Spin for a Cure 3. Blair County Diabets Walk & Family Fun Day 4. Scotland Elementary School.

Visit Facebook.com/WalgreensWalkDRI to join the conversation and get involved next year!

After the Walk, fun ensued with bounce houses and slides, a video game truck, the Gatorade Junior Training Camp, a vintage car show, a sandcastle exhibition, live music and more. Vendors supplied giveaways, and Walgreens pharmacists offered screenings and health tips.

Other local VIPs in attendance included: Tim Hardaway, John Offerdahl, Dick Anderson, Nat Moore, Bobby Harden, Chris Conlin, Shawn Wooden, Miss Carnaval Lorena Placencia, Miss Cuban American Daniela Garcia, John "Footy" Kross and Scott “Froggy” Langley. Among the top sponsors were: Listerine, Neutrogena Suncare, Zyrtec, OneTouch, Miami Dolphins, Pepsi, Coca-Cola, Frito Lay, Clear Channel, Red Bull, Vita Coco, and Chelly Cosmetics.

Clint Smethurst, Tom Karlya, Georgia Lehoczky, Roy Ripak, Donna Shalala, Robert Pearlman and Deborah Chodrow.

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UNDER THE MICROSCOPE WITH DR. CAMILLO RICORDI

If you traveled to Spain or Japan, Italy or Argentina, Israel or China -or many other countries in between -- you could find top diabetes researchers working on parts of the DRI BioHub. This multinational effort is part of the DRI’s strategy to accelerate research and overcome barriers to making progress toward a cure, be they economic, regulatory, political or otherwise.

While the DRI is based in Miami, FL, it is the hub of the DRI Federation, a worldwide network of 35 research centers.

“We have become a global enterprise that is unprecedented in academic medicine,” said DRI's Scientific Director Camillo Ricordi, M.D. In addition to the Federation, the DRI is part of The Cure Alliance, a group of scientists working to cure different diseases. They share strategies and results, believing that what they learn about one

Q. When will the DRI BioHub be available to patients?

A. We are aggressively moving the BioHub toward clinical trials. We anticipate that the first clinical trials to test components of the BioHub will take place in 2014, and we’ve already started down the regulatory path with the FDA. We will test transplanting islets alone within scaffolds made of clinical grade silicone. This material has been used clinically in many applications and therefore should more easily receive FDA approval. The study will also evaluate the placement of this BioHub platform within the omentum (abdominal lining) and its ability to regulate blood sugar levels.

We also are submitting protocols to the FDA in collaboration with Dr. Suzanne Ildstad at the University of Louisville, and with Northwestern University, to perform the first trials that will specifically target islet transplantation that completely eliminate the need for antirejection drugs. So it’s very exciting.

Q. How can people enroll in the clinical trials?

A. The best way to remain informed as to when clinical trials will begin is by becoming a DRInsider on our website, at Diabetes Research.org. For sure, we will announce it and it will be known when enrollment will begin.

We expect to be enrolling patients possibly before the end of this year and for sure next year.

Q. What progress have we seen leading up to these clinical trials?

A. We have tested several components of the BioHub in sub-human primates, including co-transplanting islets with “helper” cells (mesenchymal stem cells) within the scaffold platform, and testing this within an omental pouch (an abdominal lining).

disease could help cure another.

Such collaboration is a core value of the DRI. It’s never been more important than now – as we push to accelerate the development of the DRI BioHub. Since the BioHub was announced in March, it has received a tremendous amount of attention.

People with diabetes and their families are excited about the potential, and have been asking many important questions.

To get answers, DRIFocus went “Under the Microscope” with DRI Scientific Director Camillo Ricordi, M.D.

We have also tested our conformal coating cell encapsulation strategy in which we “shrink wrap” the islet cells with a protective barrier. After several modifications, the coatings were able to protect transplanted islets from rejection while maintaining normal blood sugar levels in the experimental models.

In these studies, diabetes was reversed in less than one week and the islets continued to function long term without the use of any anti-rejection drugs.

We also are conducting clinical trials at collaborating DRI Federation centers, showing that it is possible to substantially decrease immunosuppression after infusion of mesenchymal stem cells.

Q. The BioHub is a combination of several interrelated strategies. How do you envision these emerging?

A. I see us restoring self-tolerance and eliminating autoimmunity by inducing chimerism (ongoing collaboration with Cure Alliance's Dr. Suzanne Ildstad from University of Louisville and collaborators).

The same technology already has been successful in eliminating immunosuppression -- anti-rejection drugs -- in organ transplantation. That’s been working for more than three years and counting. We believe we can use this when transplanting insulin-producing cells within the BioHub.

Clinical trials at collaborating Cure Alliance centers are indicating that it is possible to discontinue anti-rejection drugs after tolerance-inducing protocols.

The additional technologies incorporated in the BioHub could represent alternative or complementary ways to avoid treating the recipients with anti-rejection drugs. That remains the central objective of the entire project.

There is now critically important data on the venous sac as a viable possible alternative to bio-artificial approaches.

The BioHub will eventually be applicable to any source of insulin-producing cells. Using islets is just the first, not the final, step.

We have new immunomodulatory molecules that were not available a few years ago.

These already have been shown to be effective in reversing type 1 diabetes in experimental model systems.

Q. What source of islets do you believe holds the most promise for widespread use?

A. The DRI is pursuing a number of cell sources. These include porcine (pig) islets since pig insulin is almost identical to human insulin with the exception of one amino acid; regenerating islet cells from a patient’s precursor cells; reprogramming (transdifferentiating) other cell types in the body to become insulin-producing cells; and different sources of stem cells.

We also have oxygen-generating technology and drug delivery systems to optimize the local micro-environment of the BioHub, which were not available a few years ago.

All of these advances make us increasingly optimistic about our ability to successfully transfer these components to the BioHub platform -- and that biologic replacement of insulin-producing cells without systemic immunosuppression is within our reach.

Read the continuing UTM interview at DiabetesResearch.org/UTM-Ricordi.

AROUND

THE DRI DRI RESEARCHERS AWARDED DISTINGUISHED MARC S. GOODMAN PRIZE Two of the DRI’s promising investigators, Chris Fraker, Ph.D. and Giacomo Lanzoni, Ph.D., have been selected to receive the first annual Marc S. Goodman Outstanding Young Scientist Prize at the Diabetes Research Institute.

This prestigious honor carries an award of $10,000, which the scientists will use to advance their research toward a biological cure for type 1 diabetes. Dr. Fraker, who has type 1 diabetes, will continue his work in optimizing islet encapsulation. Dr. Lanzoni will advance his work in identifying stem cell sources that could serve as a plentiful supply of beta cells. Both research areas are an integral part of the DRI’s scientific program and build upon decades of research in this area.

Candidates for this prize were presented to Marc S. Goodman by DRI Director Dr. Camillo Ricordi, whose recommendation was based upon the merits of their research as well as their commitment to our mission to cure diabetes.

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1. Dr. Giacomo Lanzoni (standing) with Dr. Luca Inverardi (in the foreground) 2. Dr. Chris Fraker

The fund was established to recognize Marc's leadership as national chairman of the DRI Foundation at the end of his tenure in 2007. It also honors his extraordinary dedication to finding a cure for diabetes, which became his passion after losing his daughter, Stacy Joy, to the disease at age 17.

PRESTIGIOUS ACCREDITATIONS REFLECT DRI’S COMMITMENT TO QUALITY AND ADVANCEMENTS FOR PATIENTS At the DRI, our research strategy focuses on bringing promising findings from the lab to patients in the fastest, safest and most efficient way possible. Our ability to translate new therapies to clinical application is significantly enhanced by having our own human cell and tissue processing facility, called a cGMP facility, right within the DRI building. cGMP refers to the Current Good Manufacturing Practice regulations and standard operating procedures (SOPs) enforced by the Food and Drug Administration (FDA) for proper design, monitoring and control of manufacturing processes. In addition to being FDA compliant, the DRI’s cGMP has also earned accreditation by both FACT (Foundation for the Accreditation of Cellular Therapies) and AABB, two of the most prestigious accreditation organizations in the world. The DRI was one of the first cGMP-compliant facilities in an academic setting and is currently one of only four such facilities that have been AABB and FACT accredited.

The cGMP provides DRI researchers with the highest level of control over the quality and safety of all cell products to be used in research, and most importantly for clinical use, like for the DRI BioHub and other patient studies. It also eliminates the need to wait for cells and tissues to arrive from other sources, minimizing any delays.

In addition to using these biological products for its own research, the DRI processes a wide variety of cell and bone marrow-based products for other investigators and companies in South Florida and throughout the country. According to Elina Linetsky, Ph.D., DRI’s director of quality assurance and regulatory affairs, the accreditation distinguishes the Institute from other cell processing centers.

“In order to be accredited by both FACT and AABB, we need to meet their standards, which are stricter than the FDA's. The accreditation improves the way we function and produce our products, which also gives us credibility with other researchers with whom we work. More and more often I get asked by investigators about our accreditation when they prepare their regulatory submissions. I think it is very beneficial to us,” said Dr. Linetsky, who was recently asked by FACT to serve as one of their inspectors and interviewed for an article in the April 2013 issue of their newsletter, Telegraft.

“The accreditations by both FACT and AABB demonstrate DRI’s committed to the highest standards of quality and excellence for patients as we move cellular therapies and biological replacement strategies for the cure of diabetes to our final goal,” said DRI Director Camillo Ricordi, M.D.

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UNIONS HISTORY IN THE MAKING An annual effort dubbed D.A.D.’s (Dollars Against Diabetes) Day began with collecting donations on street corners every Father’s Day. It grew and eventually morphed into what it is today – the conglomeration of more than 70 fundraising events held around the United States, including golf tournaments, poker runs, bowling tournaments, softball tournaments and even some of the same bucket collections that started it all.

Presented by Sean McGarvey (r), president of the Building and Construction Trade Department of the AFL-CIO, to Tom Karlya, vice president of the Diabetes Research Institute Foundation, this check represents one of several that will combine to total $1 million in funds raised for the DRI this year.

Led by President Sean McGarvey and Secretary-Treasurer Brent Booker, the men and women of the Building and Construction Trade Department (BCTD) of the AFL-CIO have shown their determination to rid the world of diabetes time after time. Long ago, when asked if they could help in the cause of the Diabetes Research Institute, the group’s response went above and beyond the request with a promise to not only build the world-class facility, but also to raise money for the work that would take place inside it. The 87,000 square foot beacon of hope for a diabetes cure standing in Miami today exists because of this group, and their dedication has only multiplied.

The largest of these events, the 29th Annual Labor of Love, was held this year in Baltimore, MD, May 17-20. Hundreds participated in The Annual Bricklayers and Allied Craftworkers’ Softball Slam, which was played in Oriole Park at Camden Yards, thanks to the generosity of Event Host Peter Angelos. Guests were invited to be spectators of the running of the Preakness Stakes at Pimlico Race Track. And the much-anticipated Labor of Love golf tournament took place at Baltimore Country Club. Angelos also welcomed all to join him at Camden Yards for Labor Night, as the Orioles took on the Yankees. In this one weekend, $600,000 was raised for the DRI. Combined with the D.A.D.’s Day events occurring in June, the BCTD’s annual donation is expected to once again top $1 million. Over the years, these men and women have so generously given of their time and efforts that total contributions to the DRI have surpassed $45 million, historically making the BCTD the largest single contributor to our mission.

SUPPORT OUR WORK WHILE DOING YOURS Many companies encourage employees to support charitable organizations through workplace giving campaigns. These gifts are tax deductible and can be made through a payroll deduction program. Simply select the DRI Foundation from your company’s charitable choices and encourage your co-workers to do the same. If the Foundation is not already an option, you can further assist by working with us to determine how to go about being included.

For participants in the Combined Federal Campaign (CFC), our number is #11149. We are also listed under the Health 1st America’s Charities Federation. The easiest way to find us is in the alphabetical index at the back of your campaign guide. If your company holds a United Way campaign, you have the opportunity to contribute to the DRI Foundation by utilizing the write-in feature. Please call 1.800.321.3437 or email info@drif.org if you have any questions.

PARENTS EMPOWERING PARENTS

A PEP TALK ON KIDS HEADING TO COLLEGE Every parent worries when their children leave the nest for college. With diabetes, there are even more challenges and concerns. Everything can affect blood sugars – from walking across campus and erratic schedules to stress, parties and alcohol. A little preparation and effective communication can make the experience the exciting rite of passage that it should be.

“The most important thing is to treat your child as a kid going off to college, not the diabetic that you need to have control over,” said Dr. Carol Nudelman Blumberg, a clinical psychologist and a PEP Squad leader, whose daughter, Ashley, was nearly 11 when she was diagnosed in 2000.

Now a graduate of Washington University in St. Louis, Ashley admitted that she was a little nervous at the time, but none of her fears were diabetes-related.

“My parents made sure I was in charge of my own care before I headed to college. We also had a big health center on campus, which made it easy.”

Carol continued, “We tested the waters in high school, and she Ashley Blumberg and Carol had proven to be reliable. We Nudelman Blumberg had some slip-ups along the way, but we were in a good place.” Ashley had been on a several trips away from home during her teen years that helped strengthen her parents’ confidence in her ability to communicate with them and care for herself. “Whatever level of communication currently exists with your child is what you should expect when they leave for college. It’s important to establish a level of trust beforehand.”

Prior to the big move, the Blumberg family sat down together to discuss expectations. “My husband, Morty, and I told her that she wasn’t going to college without taking the Mastering Your Diabetes course at the DRI. That was a requirement for us paying tuition.” She continued, “I think the best advice is to let them know how you feel and what you hope they will accomplish.”

DRI’s Director of Education Services Kellie Rodriguez, MSN, CDE, CPT, agreed that it’s best to empower budding young adults. “When a child is diagnosed with diabetes at a young age, the parents are very involved with management. They have to be, and sometimes they stay in that role through the teen years,” said Kellie. “That’s why the transition to

college can be a daunting experience for the teenager who wants that independence and the mom or dad who is having a hard time letting go of the reins.”

Similarly, PEP member Stacey Nagel said that given her son, Jesse, was very independent prior to going to college and had already done some traveling on his own, she felt prepared for the transition.

Still, it didn’t stop the overwhelming feelings of worry during those first few weeks.

Stacey and Jesse Nagel

“I was insane! My biggest fear was he would go low and die,” Stacey stated candidly. “But, I’ve taught him well.

He’s living a full life. He’s a lifeguard, the president of Hillel; he’s active and outgoing. I trust him.” Jesse is a junior and recently transferred to D’Youville College in Buffalo, where he is studying to be a nurse. He was diagnosed with type 1 diabetes 11 years ago.

A few tips from Stacey include making “a box with all of the diabetes supplies and taping all of our emergency phone numbers on the top.

We added a sick day box with cold medicine and other necessities. We also made sure the resident advisor knew what to do in case of a low, and we taught his close friends how to give glucagon,” she said.

“Some parents want their kids to go to a local college, but eventually you have to let go…that’s the hard part. Even now that he’s an adult, I still worry.” Stacey then confessed, “When he’s home on breaks, I check his blood sugar in the morning while he sleeps in. It gives me peace of mind.” Whatever works!

OTHER TIPS TO SMOOTH THE TRANSITION: • Know your rights, as a student, in the admissions process, disability services and academic modifications: Diabetes.org/living-with-diabetes/know-your-rights • Visit CollegeDiabetesNetwork.org for great tips and resources.

• Check out DrinkingwithDiabetes.com for a host of fact sheets, an alcohol IQ quiz and ways to start an open and honest dialogue with your college student.

• Enroll in Mastering Your Diabetes, a five-day, intensive diabetes selfmanagement program that puts YOU at the center of your diabetes management: DiabetesResearch.org/Mastering-Your-Diabetes • Join the PEP Squad on Facebook for support: Facebook.com/groups/PEPsquadDRI

40 YEARS OF LOVE AND HOPE After four decades of hands-on work, the Love and Hope Committee has raised nearly $50 million cumulatively for the DRI. Led by Life Chairman Sonja Zuckerman, Executive Chairman Sandra Levy, International Chairmen Linda and Barry Gibb, and National Chairman Kathy Simkins, the group is now gearing up for the 40th season of Love and Hope. Save

the date of November 23, 2013, to attend the underwriting Preview Party at a new location, The St. Regis Bal Harbour Resort. And plan to take your Valentine to the 40th Anniversary Love and Hope Ball to be held February 15, 2014 at the Westin Diplomat Resort & Spa!

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EVENTS PREVAIL AFTER EPIC SUPERSTORM Making landfall in New Jersey on October 29, Sandy was the deadliest hurricane to hit the U.S. East Coast in 40 years. Spanning some 1,000 miles in width, it pounded several states with hurricane-force winds, rain and even snow, causing severe damage and flooding.

The storm was blamed for more than 2.8 million power outages across the Northeast. Hundreds of thousands of families lost their homes. Many members of the DRI Foundation family were affected.

Despite personal loss, their dedication to the Diabetes Research Institute did not waver.

Scheduled to occur just three days later on November 1, the 14th Annual Fall Into Fashion luncheon was postponed until November 30, and the fashion show element of the affair had to be cancelled.

Regardless of the changes, a crowd of more than 250 guests, including television icon Susan Lucci, gathered at the Fresh Meadow Country Club in Great Neck, NY, to show their support. Thanks to the hardworking committee, led by Chairperson Barbara Hatz as well as the generosity of presenting sponsors Roberta and Larry Helfant & Family and Roberta and Bruce Waller & Family, the event raised more than $232,000.

Taking place two weeks after the storm on November 13 was the Fifth Annual All in for a Cure, which according to some was the best one yet, raising in excess of $300,000! Affording breathtaking views of Manhattan, The Grand Havana Room played host to this texas hold’em poker tournament. Co-chairs Samantha Shanken Baker, Jordan Dickstein, Troy Gregory, Isaac Khafif, Greg Rosenberg and Ricardo Salmon filled the room with more than 200 colleagues, friends, and business associates. Among the evening’s guests was World Series of Poker player Beth Shak, famed not only for her poker-playing prowess but also for her impressive (1,200-pair-and-

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counting) shoe collection. Special thanks were given to the lead sponsor, Affinity Marketing Partners.

Also happening in Manhattan, the always-elegant Empire Ball succeeded in raising more than $1.2 million at the Grand Hyatt Hotel on December 12. Three distinguished real estate industry notables were feted that evening. The recipient of the Empire Ball’s 2012 Leadership Award was Jason D. Pizer, president and CEO of Trinity Real Estate. Richard Wood, president of Plaza Construction, was presented with the Camillo Ricordi Humanitarian Award. And Frank A. Freda, executive managing director, Cushman & Wakefield, Inc., was bestowed the Distinguished Service Award. The event was chaired by Peter L. DiCapua, formerly of Atco Properties & Management, Inc., and now chairman at CodeGreen Solutions. Nearly 1,000 attendees listened as he summed up the sentiments of everyone at the DRI and Foundation.

“I am so proud of the real estate community here in New York, who helped make this event one of the most successful to date. Everyone really stepped up to the plate this year. With so many families and companies affected by Hurricane Sandy and so many fundraising efforts focused on helping rebuild the TriState area in its aftermath, I am just overwhelmed at the huge show of support for our cause and even greatly surpassing last year’s efforts. Let’s continue to raise more awareness and more money for this deadly disease.”

In the wake of this epic superstorm, as citizens of the Northeast rallied to support their communities, it was truly touching to see so many members of the DRI family upholding their dedication to our shared mission to find a cure. We laud our Supersupporters!

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1. All in for a Cure Co-chairs Jordan Dickstein, Isaac Khafif, Samantha Shanken Baker, Troy Gregory, Greg Rosenberg and Ricardo Salmon 2. Sue Gillin, Susan Lucci and Barbara Hatz 3. DRI Scientific Director Dr. Camillo Ricordi with Honorees Richard Wood, Jason D. Pizer, Frank A. Freda, Empire Ball Chairman Peter L. DiCapua and Special Guest Emcee David Ushery.

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EVENTS

Chatham Turkey Trot

The Fourth Annual Chatham Turkey Trot took 435 participants on a scenic adventure through the Highlands section of Chatham Township, NJ, on Thanksgiving Day. Led as always by Curt Ritter, the event raised $14,300 for the Chatham Township Volunteer Fire Department and the Diabetes Research Institute. Winners of the One Mile Family Fun Run and 5K Race were (l-r): Mollie Ritter, Owen Reddington, Angelica Burns, John Hendy, Kayleigh Wolff and Tommy Hyland.

Pleasures of the Palate Returning to the event he helped create more than 14 years ago, Chef Norman Van Aken (2nd from right) effectively fulfilled the culinary wishes of more than 150 bon vivants at Pleasures of the Palate on January 13 at La Gorce Country Club in Miami, FL. Thanks to his involvement, as well as the dedication of Event Chairs Tammy and Steven Klein (left), Wine Chairman Sue Gallagher, and other generous supporters, the evening produced in excess of $100,000. The recipes Chef Norman used while preparing the delightful meal in cooperation with La Gorce Country Club’s Executive Chef Tim Nickey, came straight from his new book, My Key West Kitchen, which he co-wrote with his son, Justin Van Aken.

Each course was perfectly paired with wines from Republic National Distributing Company. Among the featured speakers were DRI Foundation President and CEO Robert A. Pearlman (center), DRI Scientific Director Dr. Camillo Ricordi (right), and Carly Klein, a University of Miami student who was diagnosed with type 1 at age 5.

It’s a Charity Thing Each month comedian and actress Alyse Kenny (AlyseKenny.com) creates, produces, and performs in a special show called “It’s a Charity Thing” at Gotham Comedy Club in NYC, and each month she chooses a new cause to support. Marking the event’s one year anniversary, the show held on January 30 benefited the DRI and featured an impressive lineup of national headliners and TV comedians, including Sherri Shepherd of The View. Other professional stand-up comedians supplying laughs that evening were: Harrison Greenbaum, Eddie Brill, Carmen Lynch and Jimmy Failla. An extra element of fun was added with prize drawings, courtesy of Inserra Shop-Rite Supermarkets, B.R. Guest Restaurants, and Riedel.

IMAGE Casino Night Represented by Bruce Jacobson, publisher, and Donna Halperin, editor-in-chief (both pictured left,) Image Magazine hosted a Night at the Casino dubbed “Bet Against Diabetes” at Carlyle on the Green in Farmingdale, NY, on January 30. Guests danced to the music of a deejay, shopped with boutique vendors, and enjoyed food, cocktails, goody bags and fabulous auction prizes. Donna was inspired to create the fundraiser for her close friends, Korey and Sam Liebman, whose daughter has type 1 diabetes and who matched the amount raised that evening with a gift for the DRI of their own. Pictured (right) are DRI Foundation Northeast Director Tony Childs and Long Island Director of Special Events Lily Scarlett.

A Gift of Love…A Gift of Hope The Polo Club of Boca Raton, FL, once again played host to the A Gift of Love…A Gift of Hope luncheon, organized for the 14th year by the Palm Beach Auxiliary. Chaired by longtime committee leader Renee Aronin, the event featured a shopping boutique, plus lunch and a card party. This year’s featured speaker was DRI Patient Ambassador Michelle McGann (pictured), an LPGA golfer with type 1 diabetes.

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EVENTS Love and Hope Preview Party and Ball Led by Life Chairman Sonja Zuckerman (far left) and Executive Chairman Sandra Levy (center right), the dedicated ladies of Love and Hope succeeded once again in impressing 400+ guests with stunning décor and surprises at the 39th Annual Love and Hope Ball. Held February 2 at the Westin Diplomat Resort and Spa in Hollywood, FL, this extraordinary black-tie gala, combined with November’s Preview Party, which was once again hosted by Isabel May, raised more than $1 million. Mistress of Ceremonies Lisa Petrillo recognized the evening’s honorees, including Honorary Chairman Shirley Harris (far right); Love Honoree Betty Madigan Brandt, Hope Honorees Robin and Jordan Weitz, Gold Stars Beatrice and Dr. Sanford Ziff, and Silver Stars Sandy and Senator Paul Steinberg, as well as the sponsors, Donna and George Zoley of The GEO Group, Joseph Lubeck and Sid Levy of Landmark Residential, Neiman Marcus Bal Harbour, Saks Fifth Avenue Bal Harbour and Miami Magazine.

three D: Dine, Drink, Discover Led by Jill Hirsch, Amy Greenwald and Jillian Posner, (shown l-r with Robert A. Pearlman) the three D committee delivered on its promise to give guests an evening to Dine, Drink and Discover something new at the Rubell Family Collection in Miami, FL, on Friday, March 1. Special guest Ron Darling, former MLB pitcher, current color commentator and DRI Foundation national board member, addressed more than 300 attendees, giving special thanks to top sponsors, including: Jonathan and Lexi Greenwald, Jill Viner, The Greenwald Family & Michele Hill, Rand Eye Institute, The Madan Family, and The Weinstein Family. Proceeds of the event, which featured intriguing works of art and astounding entertainment, reached nearly $150,000.

PEP Talk Mini Conferences Hosted by the PEP Squad (Parents Empowering Parents) of the DRI Foundation, this ongoing series of half-day sessions for families living with type 1 diabetes focuses on the psycho-social issues of the disease. On March 9, a PEP Talk mini conference was held at Joe DiMaggio Children’s Hospital in Hollywood, FL, and on April 13, another was held at the DRI. Featured presenters included: Wendy Satin Rapaport, PsyD, LCSW; Ilene Vinikoor, LCSW; Kellie Rodriguez, MSN, CDE, CPT; Janine Sanchez, MD; Robin Nemery, MD; and other diabetes experts. Parents and kids alike learned from the program faculty, as well as each other, discussing topics such as problem solving, empowerment, meeting new challenges, communication and managing relationships.

Carnival for a Cure The Eighth Annual Carnival for a Cure took place at the Metropolitan Pavilion in NYC, on Sunday, March 10. More than 400 fun-seekers of all ages attended, enjoying arts and crafts, bounce houses, gladiator jousting, balloon art, arcade games, a racetrack, a mechanical bull, pop-up basketball, Ultimate Gaga, and more! Co-chairs included: Ronnie and Harry Agress, Meredith and Scott Buchwald, Jena Kingsley, and Brett and Daniel Sundheim. The event emcee was once again CBS 2 News Anchor Chris Wragge. Pictured: Carnival for a Cure committee.

Kids Party for a Cure Celebrating its 10th Anniversary, Kids Party for a Cure was held on Sunday, March 10, at Dave and Buster’s at the Mall at The Source in Westbury, NY. Leading the event were Co-chairs Frankie Lam and Sheri Donaldson and Honorary Chairperson RenÊ Checchia.

Top sponsors included: Drs. Mitchell and Walter Rubinstein and Family, Astoria Federal Savings Bank, Debra and John Carrion, and Rene and Larry Mandel. Highlighting the fun for all was special guest Carly Rose Sonenclar, pictured second from left with (l-r) Jared Lam, Matthew Donaldson and Grace Checchia.

An International Affair Held in honor of Randi Fibus Caster (center), An International Affair occurred at the home of Sherry and Steve Einhorn (right) in The Polo Club of Boca Raton, FL, on March 16. Guests of this intimate fundraiser described it as their own private Cirque du Soleil show! Entertainers from cultures around the world performed, and delicacies were served up from the internationallyacclaimed restaurant impresario Barton G. Also pictured (left) are Jeanne Fibus and Ron Caster.

Shopping for a Cure at Fixx In their fabulous shop called Fixx, DRI Foundation board member Miriam Shiff and her partner, Diana Mollica, along with Ellen Lux, hosted a fundraiser on March 19 in Great Neck, NY. Attendees enjoyed lunch and chased away some of the winter doldrums by shopping the colorful fashions of spring. FIXX and Ellen Lux Jewelry donated 15 percent of all purchases to the DRI. Pictured (l-r) are: Eileen Zinn, DRIF board member Barbara Hatz, DRIF NE Region Director Tony Childs, Mollica, Shiff, Roberta Helfant, Daria Forrest and DRIF board member Louise Pashcow.

Fashion and Beauty Week Now in its second year, Fashion and Beauty Week raised $52,000 for the DRI beginning with its Runway Gala held at The Venetian in Garfield, NJ, on March 19.

The kickoff event featured designer shows, a full cocktail dinner, a Lord & Taylor beauty bar, luxury lounge brand experiences and more! Attendees were invited to mingle with celebrities, stylists, fashion and beauty editors, industry icons and designers such as Monique Lhuillier, Kelsy Zimba, THEIA, Jay Godfrey, Melissa Odabash, Naven, Sue Wong, Adrian Alicea, Robert Graham and JS Collections.

A newly added extension to the gala, Fashion and Beauty Week Nights Out, were held from March 20-24 at department stores, boutiques, salons, spas and restaurants. The special in-store events included shopping, dining, services and more. Pictured at the Runway Gala are (l-r): Dr. Camillo Ricordi, John Hughes, Lindsey Inserra, Bonnie Inserra, FBW Founder Jack Panico, Gary Kleiman and Aimee Siegel-Harris.

American Fine Wine Competition Celebrating the finest wines made in the United States, the Sixth Annual American Fine Wine Competition Gala began on April 4 at Boca Raton Resort & Club in Boca Raton, FL, with a Sparkling Reception among winery tasting rooms and an extensive silent auction. It continued with a gourmet feast prepared live by renowned Chefs Norman Van Aken, Angelo Elia, Dean Max and Christina Machamer. Ms. Hilary Kole entertained, and wine angels poured more than 600 varieties of wines. Pictured with DRI Foundation COO Deborah Chodrow (right) are Steven Mariano of Patriot National Insurance Group, presenting sponsor, and Shari Gherman, who co-founded the event with Monty and Sara Preiser.

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EVENTS Cooking for a Cure Once again Nassau County Legislator and DRI Foundation board member Delia DeRiggi-Whitton led her committee to create a fabulous evening of gourmet delights at Page One Restaurant in Glen Cove, NY. The 10th Anniversary Cooking for a Cure honored Dr. Barbara Keber, associate director of the Family Medicine Residency program at Glen Cove Hospital, who was recognized for her expertise, professionalism and creativity in helping individuals with diabetes learn how to effectively manage their disease.

The event was sponsored in part by Page One Restaurant, which is co-owned and co-operated by Peter Antonopoulos and Chef Jeanine DiMenna, who is also a member of the committee. Pictured with DeRiggi-Whitton (3rd from right) and Keber (center) are (l-r): Councilman Reginald Spinello and Judge Richard McCord, plus Nassau County Legislators Wayne H. Wink, Jr., Francis X. Becker, Jr., and Carrie Solages.

Vince Wilfork’s Draft Day Fundraiser Now entering his tenth season with the New England Patriots, Vince Wilfork, along with his wife, Bianca, (pictured with Tom Karlya) celebrated a decade of something else – hosting an annual draft day fundraiser for diabetes. Two dozen Patriots players, more than ever before, along with a sold out crowd of fans, were at Pinz in Milford, MA, on April 25 to show their support for Vince and the charitable work he does in honor of his father, who passed away from complications of diabetes. Approximately $300,000 was raised this year, and the Wilforks designated a portion of it to the victims of the Boston Marathon Bombing.

Shell Key West Fishing Challenge Pictured prior to the 8:30 a.m. “lines-in-the-water” call are three generations of the Blaylock family, who gathered to celebrate the 25th Anniversary of the Shell Key West Fishing Challenge: Hayden Blaylock; his daughter, Crystal Blaylock Sanchez; and her sons, Matthew Sanchez (back) and Cameron Sanchez. Thanks to Shell Oil and Motiva Enterprises, their affiliates and friends, and Blaylock Oil Company, this event has surpassed the half million dollar fundraising mark for the DRI in just six years. At the Cocktail Party and Awards Banquet held at Ocean Key Resort and Spa in Key West, FL, the crowd mingled with Dr. Camillo Ricordi, Luca Inverardi, and Mitra Zehtab, learning more about the work they so generously support.

The Crystal Ball Presented by Bruce and Roberta Waller and Family, The Crystal Ball raised $555,000 for the DRI on May 4 at The Garden City Hotel in Garden City, NY. The black-tie affair, which annually attracts some of Long Island’s most prominent business leaders and philanthropists, featured spectacular décor, music, dancing, fabulous food and an exclusive live and silent auction of one-of-a-kind items. The event, chaired by Michael Genatt and Bruce Waller, gave tribute to Howard Rowland, president of E.W. Howell Corporation, who served as honoree, and Peter J. Klein, CFA, president of The Claire Friedlander Family Foundation and senior vice president of investments at UBS, who received The Gillin Family Humanitarian Award. Pictured are DRIF board members Charles Rizzo (far left) and Doug Donaldson (far right) with Rowland and DRIF LI Regional Chairman Allan L. Pashcow (2nd from right).

D.R.E.a.M.S. in the city Reflecting Diabetes Research, Elegance and Modern Sophistication as always, D.R.E.a.M.S. in the city was held at the iconic Pierre Hotel in Manhattan on May 7 and honored Kim Dickstein with the Dare to Dream Award (pictured with DRIF Chairman Harold Doran) and the Stacy Joy Goodman Memorial Foundation as the Humanitarian (pictured Ken Shewer, Susan Winberg, Marc and Esther Goodman).

More than 400 guests attended the eighth annual event, which raised in excess of $900,000. Lindsey Inserra served as Young Professionals Chair, while longtime event leaders Bonnie Inserra, Samantha Shanken Baker, Meryl Lieberman and Diane Cohen co-chaired. Alan Kalter, famed voice of Late Show with David Letterman, brilliantly emceed D.R.E.a.M.S. for the fourth year in a row. The Jay Prince Band once again provided music that set the joint jumping.

Warmest thanks are extended to top sponsors The Inserra Family and Jane Parker and Francis Cosentino.

Don Strock Diabetes Golf Classic Presented once again by Miami Seaquarium, the 30th Anniversary of the Don Strock Diabetes Golf Classic attracted more than 150 golfers to Miccosukee Golf and Country Club in Miami, FL, on May 8. Tournament Host Don Strock and Chairman Bruce Fishbein, who founded the event three decades ago, gave special recognition to sponsors – mostly from the produce industry – who have signed on year after year. Thanks were also extended to Strock’s former Dolphins teammates and other local notables who have helped make it one of South Florida’s longest running celebrity/amateur charity golf tournaments. DRI Foundation national board member Arthur Hertz, chairman and CEO of Wometco Enterprises, Inc., which owns Miami Seaquarium, is pictured (center) with Fishbein (left), Strock (right) and Miami Seaquarium characters just before tee off. The event raised nearly $140,000, which pushed cumulative proceeds close to $3 million!

Haute Tea Presented by the Young Society of Love and Hope and the St. Regis Bal Harbour Resort, the second annual Haute Tea luncheon was the place to be on May 21 for South Floridians with a penchant for high fashion and philanthropy. According to Co-chairs Jillian Posner (center) and Dana Rosenhaus Swickle (left), the soiree produced nearly $60,000 for the DRI and attracted nearly twice the attendees as the premier event. Transformed into a “vintage garden,” the ballroom at the St. Regis Bal Harbour Resort in Bal Harbour, FL, held an extensive silent auction arranged around topiaries and a grass runway. As they watched a fashion show by Neiman Marcus Bal Harbour, guests dined around gorgeous centerpieces, which were delicately adorned with flowers and butterflies, as well as a variety of dangling teacups. A formal tea service was offered with silver provided by Christofle Paris, represented by Justin Trabert (right). Watch the recap video at DiabetesResearch.org/Haute-Tea-2013-photos.

Brenda Novak Online Auction for Diabetes Research Brenda Novak, a USA Today and New York Times bestselling author, has reached $2 million in fundraising with her annual Online Auction for Diabetes Research in honor of her son, Thad, 16, who has lived with type 1 diabetes for over a decade.

Raising more than $360,000 in its ninth year, the 2013 auction, which took place at BrendaNovak.com throughout the month of May, was dedicated to another little boy, Ben, 2, who was diagnosed with type 1 just months ago. Ben is the son of fellow author, Lauren Hawkeye Jameson (of Alberta, Canada), who has been supporting the auction for years. More than 5,000 supporters throughout the country and beyond bid on an array of one-of-a-kind items due to Novak’s close connections in the literary world, such as private meetings with prominent authors, including a NYC lunch date with Lee Child, whose macho “Jack Reacher” character was played by Tom Cruise on the big screen late last year. Other hot items included a pair of concert tickets and Meet & Greet with Bret Michaels, who has type 1 diabetes, a signed leotard by Olympic Gold Medalist Aly Raisman, a finalist on Dancing with the Stars, and so much more.

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DRIfocus

Non-Profit Org. US Postage PAID Diabetes Research Institute Foundation

Diabetes Research Institute Foundation National Office 200 South Park Road Suite 100 Hollywood, FL 33021 address service requested

For information on the events or to make reservations, visit DiabetesResearch.org or call one of the DRI Foundation offices listed below.

CALENDAR Fishing for a Cure August 3, 2013 / MICHIGAN This local fishing tournament, held on Kent Lake in Kensington Metropark of Livingston County, MI, raises diabetes awareness and funds to support the DRI’s cure-focused research.

The Rod Gilbert DRI Golf Classic August 12, 2013 / LONG ISLAND To be held at the beautiful Pine Hollow Country Club, this event will honor Michael Weissman and feature a fun day of golf, followed by an awards dinner and silent auction. It is co-chaired by Eric Reeps and Bob Zuckerman.

Gold Coast Concours/Bimmerstock September 8, 2013 / LONG ISLAND Hundreds of exotic cars and BMWs will be showcased throughout the day at this magnificent exhibit, to be held at the City of Glen Cove’s downtown

DRIfocus Marketing & Communications Dept.

Lori Weintraub, APR Lauren Schreier Natasha Norris Laurie Cummings

business district and presented by Martino Auto Concepts/MAC Auto Couture and Exotics4Life. Join us from 11 a.m. to 4 p.m., rain or shine.

Key West Poker Run September 19-22, 2013 / FLORIDA Phil Peterson will host the 41st annual motorcycle run, which starts in Miami and finishes in Key West for South Florida's biggest biker party weekend of the year.

The Donaldson Organization Golf Outing September 30, 2013 / NEW YORK The Donaldson Organization will host a golf outing at a prestigious, private golf club in Westchester County, NY. Enjoy a full day of golf, plus a hearty breakfast and lunch, followed by a cocktail reception and dinner – a golf enthusiast’s perfect day!

All In for a Cure November 5, 2013 / NEW YORK To be held at the Grand Havana Room, the sixth annual Texas Hold’em tournament will feature a silent auction, fine wines and spirits, exclusive cigars, hors d’oeuvres and a dinner buffet – all set in front of a backdrop of panoramic views of New York City.

Fall Into Fashion November 7, 2013 / LONG ISLAND To be held at the Fresh Meadow Country Club in Great Neck, this event will highlight the upcoming season’s best fashions during a splendid lunch with a prize auction and more.

Love and Hope Preview Party November 23, 2013 / FLORIDA It’s the 40th anniversary! Kick off the celebration with us at the event longago dubbed the "heart of Love and

Hope." Enjoy friends, cocktails, dinner and dancing at a fabulous new location, the St. Regis Bal Harbour Resort!

Champions for Charity December 5-7, 2013 / LONG ISLAND An annual holiday shopping benefit designed to raise funds for more than 80 not-for-profit organizations, a percentage of sales will be donated to the DRI when using a Champions for Charity Card throughout the month. Shop, shop!

Empire Ball December 11, 2013 / NEW YORK A veritable Who’s Who of New York’s real estate giants, this annual black-tie dinner dance is the industry’s social event of the season, led by Chairman Peter L. DiCapua.

is a publication of the Diabetes Research Institute Foundation.

June 2013 / Volume 40 / Issue 2 Contributors Gary Kleiman Glenn Kleiman Jill Salter Aimee Siegel-Harris Mitra Zehtab, M.D.

Photography DRI / DRIF staff and volunteers Gabriel Bancora Carl Cox Photography Marc Levine Photography Magique Studios Joe Marzo Sarah Merians Photography and Video Andrew Milne Photography James Paige Richard Yun Design Franz Franc Design Group Inc.

The Diabetes Research Institute Foundation supports the Diabetes Research Institute at the University of Miami Leonard M. Miller School of Medicine, whose mission is to develop and rapidly apply the most promising research to treat and cure those now living with diabetes. To obtain additional information or request copies of DRIfocus, please call (800) 321-3437 or e-mail lweintraub@drif.org, or visit DiabetesResearch.org.

DIABETES RESEARCH INSTITUTE FOUNDATION National Office / Florida Region 200 South Park Road, Suite 100 Hollywood, FL 33021 Phone: (954) 964-4040 Fax: (954) 964-7036 info@drif.org

Northeast Region / Manhattan Office 381 Park Avenue South, Suite 1118 New York, NY 10016 Phone: (212) 888-2217 Fax: (212) 888-2219 neregion@drif.org

Northeast Region / Jericho Office 410 Jericho Turnpike, Suite 201 Jericho, NY 11753 Phone: (516) 822-1700 Fax: (516) 822-3570 liregion@drif.org