2021 Year in Review | Department of Anesthesiology and Perioperative Medicine

Drake Wakefield, D.O., and Paige Schroder, M.D.

HOW WE OUR DEPARTMENT

As we emerge from the aftermath of the global pandemic, we have taken the opportunity to reshape and futureproof our department. This will allow us to sustain our mission to deliver excellent patient care, discover new knowledge through research, and educate the next generation of outstanding anesthesiologists.

Health care is currently challenged in a way that it has never been before. “The Great Resignation” has decimated the workforce, and priorities in relation to work-life balance have been irrevocably altered as a consequence of the pandemic. For this reason, our leadership has taken a long, hard look at how we might pivot and reframe our development priorities. We concluded that, in addition to the care of our patients, care of our faculty and staff is essential if we were to sustain and grow an outstanding academic department.

It is clear that the department’s culture is paramount to this goal. To better understand the current state and in efforts to build a strong departmental culture, we have embarked on the creation of the Culture Collaborative – the humanistic arm of our departmental mission. This is critical to the care and well-being of our enterprise. This collaborative is supported by five distinct, yet overlapping, initiatives: recruitment; retention; faculty development; wellness; and diversity, equity, and inclusion (DEI).

With regard to recruitment, we reasoned that unless we could attract the best talent to our department and expand our workforce, we would remain stagnant. This could reduce the ability for our faculty to have the necessary time and energy to pursue their academic goals and express their talents beyond the operating room (OR). In a market that is more competitive than it has been in decades, it was critical that we “up our game.” Together, with our energetic new director of faculty recruitment and the deployment of resources, we have enhanced our outreach and provided early recruitment opportunity contracts. Moreover, we have recruited more diverse and international candidates through the new J-1 visa waiver program. The proof of this intervention’s success is clear: We are the second most successful recruiter of anesthesiologists by academic medical centers in the country, onboarding 17 new faculty in 2021.

We have also turned our attention to retaining talented faculty, appointing a new director of retention. We are revitalizing our onboarding process using a more personalized and mentored approach to form early connections and collaboration. Additionally, we are

Dan Berkowitz, MB BCh Alfred Habeeb Professor and Chair UAB Heersink School of Medicine Department of Anesthesiology and Perioperative Medicine

— Harvard Business Review, “Future-Proofing Your Organization”

building a culture of social support; promoting efforts to develop informal peer mentoring and assistance, hosting social events to build peer networks, recognizing personal celebrations, and hosting open forum discussions for faculty to suggest new ideas, express concerns, and contribute to their work environment. We are empowering our physicians to become the architects of their workplace.

We recruited a faculty anesthesiologist in 2020, who is also an executive coach and organizational psychologist, to serve as director of professional development and faculty engagement. This has allowed us to offer career coaching to junior faculty growing academic careers, emerging leaders, and those looking to pivot their careers into new realms or roles. We have formally defined academic career pathways and competencies to ensure equity and transparency in our growth processes, align individuals with the right opportunities, and ultimately build strong promotion packets for interested faculty. We have also created formal coursework and workshops to promote teamwork, provide clinical research skills, cultivate emotional intelligence, and improve provider engagement.

Wellness has been labeled medicine’s “wicked problem,” congruent with the term coined in the 1970s and reflective of an issue that is poorly defined and, therefore, inherently difficult to solve. To overcome the ambiguity, we have analyzed internal data to better understand, define, and determine our path forward. The department recognizes the fundamental role we play in fostering an environment in which our clinicians thrive. This includes systemic considerations to remove work barriers while simultaneously augmenting resources to support professional success.

Our DEI Council has created a mandate for change, and many items within this mandate have been prioritized and instituted. The creation of an inaugural diversity leadership position will give significantly greater weight to the council’s initiatives, a most important element of

our innovation agenda. Our residency program has also thrived with its incremental success in recruiting a more diverse class, and we have joined a national consortium that will give select residents an international experience in Zambia beginning August 2023.

In addition to the component of humanism, science and technology are critical elements of future-proofing our department. Analytics and artificial intelligence have driven new departmental initiatives in predictive and precision medicine. Not only has our growing data science core developed and published new algorithms for determining individual patient intraoperative optimal blood pressure, but they have also collaborated with our clinicians to develop new predictive scores for identifying escalation of care in the post-anesthesia care and intensive care units. Our enhanced IT team is driving OR operations and data processing for analytics. Our research enterprise is thriving and expanding, placing us in the top 15 departments for funding from the National Institutes of Health (NIH). The recent acquisition of NIH grants by our young investigators, in addition to the recruitment of a new pain researcher, promises even greater synergy and productivity.

Looking forward, optimizing our work environment and clinical operations promises to deliver on the elements of work that allow faculty to thrive; including alignment of expertise with assignment, predictability, autonomy, and a sense of teamwork and greater purpose. To this end, our Anesthesia Care Team Optimization Committee has allowed us to envision, and now create with our CRNA colleagues, a new model of how anesthesia care can be delivered both now and in the future.

As a department of dedicated faculty and staff, we are optimistic that while we emerge into a post-pandemic world and may face uncertainty, we have implemented changes that not only define our value, but also charter a course that will allow us to grow and thrive.

As businesses rebuild in the aftermath of the pandemic, those that take the opportunity to remake and future-proof their workforce will pull far ahead of rivals.

LEADERSHIP

Dan Berkowitz, MB BCh Alfred Habeeb Professor and Chair

Jack Crawford, M.D., Ph.D. Vice Chair and Director, Division of Congenital Cardiac Anesthesiology

Sadis Matalon, Ph.D. Vice Chair of Research and Director, Division of Molecular and Translational Biomedicine

Juhan Paiste, M.D., MBA, FASA, CPE Executive Vice Chair for Operations and Integration

Vice Chair and Director, Division of Critical Care Medicine

Division of Pain Medicine

Benjamin Tuck, M.D. Vice Chair and Director, Division of Cardiothoracic Anesthesia

Thomas Lynch Executive Administrator

David Miller, M.D.

Susan Black, M.D. Vice Chair for Education

Philip McArdle, M.D. Vice Chair of Quality and Patient Safety

MISSION & VISION

The UAB Department of Anesthesiology and Perioperative Medicine strives to transform the fields of anesthesiology, and perioperative and acute care medicine, by generating and translating knowledge into superior clinical practice and education. We will provide the highest quality, compassionate care to our patients through the use of innovative practice models and an interdisciplinary approach to medical care; discover new knowledge through cutting-edge research; educate the next generation of leaders in medicine through our nationally recognized training program; and be effective leaders within our community and our profession.

Left to right: Alana Venter, M.D., Annalese Neuenschwander, M.D., Susan Black, M.D., Tekuila Carter, M.D., and Andrew Braun, M.D.

OUR VISION IS TO BECOME A DESTINATION DEPARTMENT THAT INSPIRES AND CHALLENGES US TO PURSUE OUR PASSIONS TO EDUCATE THE NEXT GENERATION OF LEADERS IN MEDICINE, DISCOVER NEW KNOWLEDGE THAT TRANSFORMS OUR SPECIALTY WHILE ADVANCING HEALTH, AND PROVIDE THE HIGHEST QUALITY, PATIENTCENTERED CARE THROUGH THE PRACTICE OF INTERDISCIPLINARY, EVIDENCE-

NEW FACULTY & STAFF

Dylan Addis, M.D.

Assistant Professor

Jonathan Blocker

Manager of Clinical Business Affairs

Christopher Carmouche, M.D.

Assistant Professor

Holly Chandash Office Associate II

Tanima Chatterjee Postdoctoral Fellow

Zachary Colbaugh, M.D. Assistant Professor

Jason Gerlak, M.D. Assistant Professor

CLINICAL PRACTICE

Our faculty work in state-of-the-art operating rooms to provide the best care during approximately 130,000 patient encounters per year.

Ryan Godwin, Ph.D. Instructor

Moheb Gohar, M.D.

Assistant Professor

Andre Gosling, M.D.

Assistant Professor

Maymunah Hicks Researcher I

Carol Anne Hopper, MPA Program Manager I

Hanna Hussey, M.D.

Assistant Professor

Patrick Hussey, M.D. Assistant Professor

Raneisha Lee Clinical Resarcher Coordinator II Terry Lewis, Ph.D. Researcher V Qiang Li Researcher II

Julie McCary

Director of Anesthesia Business Services

Joseph Norman, M.D. Assistant Professor

Christopher Paul, M.D. Assistant Professor Christopher Racine, M.D. Assistant Professor

Dawn Williams, M.A. Director of Communications

PROMOTIONS

Aftab Ahmad, Ph.D. Professor

Pulin Che, Ph.D. Assistant Professor

Brad Meers, M.D., FASE

Associate Professor Program Director, Division of Cardiothoracic Anesthesiology

James Mobley, Ph.D. Professor Jessica Schultz Administrative Associate

Sandra Sipe, M.D. Director of Clinical Faculty Assignments

RETIREMENT

Teresa Mahaffey Business Manager, Clinical Affairs

Left to right: Andrew Braun, M.D., Paige Schroder, M.D., and Brad Meers, M.D., FASE

CHALLENGE ACCEPTED:

ACTOC STRIVES TO BETTER OUR ANESTHESIA CARE TEAMS

Communication is key to excellent patient care. If lines of communication break down, it takes hard work and determination to rectify the issues and mend professional relationships. Such was the case among our anesthesia care teams; and when the issues were identified, members of our department and a devoted group of CRNAs sprang into action creating the Anesthesia Care Team Optimization Committee (ACTOC) in 2019.

“The relationship between our anesthesiologists and CRNAs was really bad. It was a really cold relationship,” says Matt Sherrer, M.D., MBA, FASA, FAACD. “But because we were honest enough to admit there was a problem, and because we cared enough to fix it, we were able to come together through ACTOC and make real improvements.”

Under the guidance of Martha Anne Rich, Ph.D., a consulting psychologist, ACTOC set out in 2021 with the goal of creating taskforces to focus on areas to address and make changes to that were both attainable and sustainable. From this plan, the teamwork, education, clinical, and scholarship taskforces were formed.

“ACTOC has become a space where we safely explore our anesthesia care teams in a group that has strong trust, professional respect, and friendship,” says Stacy Wade, M.D., ACTOC member. “The taskforces are built to encourage this mindset and provide fulfilling clinical engagement opportunities.”

The teamwork taskforce – led by Sherrer and Andy Morris, BSN, MSN, CRNA – set out to create socialization opportunities between physician and CRNA colleagues. These are playing out in many scenarios, including journal clubs to discuss academic articles and simple Q&A sessions between care team members who don’t know each other. “This doesn’t have to be a tremendously complicated or academic exercise. Let’s sit and talk and get to know each other,” Sherrer says. “It doesn’t take long to find out that we work with some really amazing people.”

Collaboration sets the tone for the education taskforce.

“The ability to partner with anesthesiologists on the front end will lead to lasting changes on the back end,” says Kesha Thurston, DNP, CRNA. “It will improve processes for our patients and create a stronger anesthesia team.”

This group, led by Paul Piennette, M.D., and Thurston, is looking forward to holding joint journal clubs with the teamwork taskforce and integrating CRNAs into the department’s Continuous Quality Improvement (CQI) conferences. They are also working with the UAB Office of Interprofessional Simulation for Innovative Clinical Practice to begin PIV/arterial line simulation.

Perry Smith, M.D., and Gary Boutwell, DNP, CRNA, lead the clinical taskforce. Their team has begun to address communication deficits that affect an anesthesia care team’s performance in patient safety as well as job satisfaction. “We have a great opportunity to optimize how anesthesia care is delivered by UAB Medicine,” Boutwell says. “We have an even greater opportunity to be the national standard for collegiality and professionalism by sharing our work through the physicians and healthcare providers who will eventually move on to other healthcare centers and communities.”

In addition, the taskforce is creating a standardized checklist for the operating room, identifying what must be discussed preoperatively, intraoperatively, and early postoperatively by members of the care team.

Our anesthesiologists work hand-in-hand with CRNAs to ensure the best possible care for patients across UAB Medicine. Pictured here are Drake Wakefield, D.O. (left) and Joel Conway, M.D. (right).

The scholarship taskforce rounds out the teams and is led by Dan Berkowitz, MB BCh, and Melissa Ramsey, CRNA. Early on, this taskforce spent time researching and discussing what value it could bring to ACTOC. They determined it would be most beneficial to document the ACTOC process “in hopes of publishing the accomplishments of all of the ACTOC taskforces to improve relations amongst other anesthesia care teams throughout the country,” Ramsey says.

In a short amount of time, ACTOC has begun positioning the department and our care teams to be among the best in the nation – setting high standards for other academic medical centers to learn from and replicate. “Realizing that we all have the same goals and motivations – a fulfilling work environment where we take great care of our patients and maximize each team member’s potential – really reframed my perspective,” Sherrer says. “I would hope that we all learn to focus far less on ‘me’ and far more on ‘we’.”

I am incredibly proud of what this group has accomplished, and we really ought to be encouraging others around the country to follow our lead. — Matt Sherrer, M.D., MBA, FASA, FAACD

DIVISIONS

PAIN MEDICINE

Peter Nagi, M.D. Interim Vice Chair, Division of Pain Medicine

Faculty within the Division of Pain Medicine foster a culture of excellence and integrity in clinical pain management, education, and clinical research in order to provide safe and effective pain management for all patients and reduce pain-related healthcare disparities.

In 2021, Prentiss Lawson, M.D., was named the new director for the Pain Medicine Fellowship. He also completed his medical acupuncture training and began offering the treatment as a complementary option for patients at the UAB Pain Treatment Clinic at UAB HospitalHighlands. Additionally, Chris

Paul, M.D., joined the faculty this year and brings his substantial knowledge in spinal cord neuromodulation to the division’s clinical practice.

“Thanks to the hard work and dedication of our division faculty, fellows, nurse practitioners, rotating residents, nurses, and staff, we are able to deliver the high-volume, outstanding quality of care that our patients expect from UAB,” Nagi says.

CONGENITAL CARDIAC

ANESTHESIOLOGY

The Division of Congenital Cardiac Anesthesiology provides exceptional anesthetic care for all of our patients within the Joseph S. Bruno Pediatric Heart Center and is composed of colleagues from the specialties of Surgery, Cardiology, and ICU Medicine. This year, the pediatric heart center was ranked No. 28 in the nation for Pediatric Cardiology & Heart Surgery by U.S. News & World Report.

Jack Crawford, M.D., Ph.D., credits the faculty’s strong integration with cardiology and surgery within the center for the outstanding care delivered to some of the most

Jack Crawford, M.D., Ph.D. Vice Chair and Director, Division of Congenital Anesthesiology

delicate patients. Patrick Hussey, M.D., has been recognized for beginning his additional training in Pediatric Cardiac Anesthesiology and bringing new insight and enthusiasm to the division.

“Thanks to the individual sacrifice and professionalism of each member of the division, our department continues to produce outcomes equivalent or better than any other high-volume pediatric heart center in the country,” says Crawford.

CARDIOTHORACIC ANESTHESIA

Despite the enormous obstacles COVID brought to health care, the Division of Cardiothoracic Anesthesia thrived in the midst of crisis. “Our team refused to let these challenges derail our mission to provide high-quality clinical care, train residents and fellows, and commit ourselves to service and research which will benefit others beyond the walls of UAB,” says Benjamin Tuck, M.D., vice chair and director of the division.

Dom Mladinov, M.D., Ph.D., successfully implemented autologous normovolemic hemodilution. And in collaboration with our cardiac surgeons, Sonia John, M.D., and Nishank Nooli, M.D., implemented a protocol for pectointercostal fascial plane blocks on patients undergoing sternotomy for cardiac surgery.

Benjamin Tuck, M.D.

Vice Chair and Director, Division of Cardiothoracic Anesthesia

MULTISPECIALTY ANESTHESIA

Tuck recognizes multiple faculty members as standouts in 2021. Brad Meers, M.D., FASE, is the director of the Adult Cardiothoracic Anesthesia Fellowship and expanded the program from three to five fellows.

“It is important for faculty to be supported in order to achieve their personal and academic goals,” Tuck says. “Striking the balance between work and life is a key component to maintaining engaged faculty, and we are currently analyzing key aspects of our practice to ensure that our faculty remain both highly challenged and highly supported.”

Bert Pierce, M.D.

Vice Chair and Director, Division of Multispecialty Anesthesia

In 2021, the Division of Multispecialty Anesthesia (MSA) provided 76,082 anesthetics in six UAB coverage sites (UAB Hospital, UAB Hospital-Highlands, The Kirklin Clinic of UAB Hospital, UAB Callahan Eye Hospital, UAB Medical West, and the UAB Proton Center) and 5,814 regional blocks that provided great success in the minimization of opioid pain medication utilization perioperatively. Within these numbers, the division managed 392 procedures for COVIDpositive patients, 292 kidney transplant-related cases, 70 liver transplantations, 1,040 Level 1 emergency procedures, and many other highly specialized, complex procedures.

“I am incredibly proud of the commitment that our faculty has shown to each other, our department, the institution, and most importantly the patients we serve,” says Bert Pierce, M.D., vice chair and director of the division. “While I am very proud of our department for its many accomplishments in its tripartite mission, I am most proud to be a member of the best group of anesthesiologists in the country.”

In the future, Pierce looks forward to strong faculty recruitment to continue building a successful division. “Looking forward, we are working diligently toward faculty recruitment with an emphasis on wellness and development of an increasingly rewarding career here at UAB,” he says.

CRITICAL CARE MEDICINE

The Division of Critical Care Medicine continues to deliver exceptional services to multiple intensive care units (ICUs) across UAB Medicine, including the Cardiac ICU, Cardiopulmonary Critical Care ICU, Surgical ICU (SICU), and Neurosciences ICU. Additionally, division faculty are in the second year of providing comprehensive coverage to two units (Cardiothoracic ICU and SICU) at Ascension St. Vincent’s Birmingham. Collectively, the division manages more than 115 ICUs beds daily.

David W. Miller, M.D. Vice Chair and Director, Division of Critical Care Medicine

David W. Miller, M.D., vice chair and director of the division, says he is especially proud of the Surgical ICU/PACU redesign project, a joint partnership with the UAB Division of Trauma & Acute Care Surgery under the guidance of Rick van Pelt, M.D., MBA, and his Clinical Practice Transformation team. This project is led by department faculty Andrew Barker, M.D., and Philip McArdle, M.D.

It expands the SICU footprint from 20 to 28 beds by using PACU as ICU overflow space and expands workforce by adding a swing shift Tuesday-Thursday and funding the continuation of nightly in-house faculty presence.

“I would also like to thank Dr. Barker for his time as Program Director for the Critical Care Medicine Fellowship and welcome Moheb Gohar, M.D., as the new fellowship director,” Miller says. “Additionally, Brant Wagener, M.D., Ph.D., should be recognized for being voted Non-Surgical Faculty of the Year by the UAB Department of Surgery.”

Miller is looking forward to exploring new modalities of care, including tele-ICU, and building a defined, unified staffing model that will maximize intensivist presence for patients. “The great outcomes and successes we enjoy as a division are directly related to the dedication and hard work every member of the division gives toward patient care,” Miller says.

OBSTETRIC ANESTHESIOLOGY

The long-standing commitment to the three missions of the department led to the recent creation of the Division of Obstetric Anesthesiology. The new division is proud to have had success with both faculty and fellow recruitment this year, with Teshi Kaushik, M.D., (Emory) and Annalese Neuenschwander, M.D., (UAB) joining the team in their respective roles.

Michelle Tubinis, M.D.

Interim Vice Chair and Director, Division of Obstetric Anesthesiology

Michelle Tubinis, M.D., interim vice chair and director of the division, recognizes colleagues Hanna Hussey, M.D., for her successful recruitment for the Obstetric Anesthesia Fellowship, and Stacy Wade, M.D., for her continued efforts into obstetric anesthesiology quality improvement.

“Our group is excited to establish ourselves within the department as a division with goals to continue to recruit strong obstetric anesthesiology faculty, increase our presence in labor and delivery, and build upon our strong reputation of excellent clinical care, collaborative research, and outstanding resident education,” Tubinis says. “Thank you to our faculty members and residents for their continued commitment to clinical excellence in labor and delivery. Because of their hard work, we continue to meet the standards as a Society of Anesthesia and Perinatology (SOAP) Center of Excellence, which is no small task.”

Scott E. Harper, M.D. Director, Division of Community Anesthesia

Expansion sets the tone for the fastpaced operations of the Division of Community Anesthesia. In December 2021, the division was tasked with taking over anesthesia services at Ascension St. Vincent’s East (see page 14 for more details). “Within a short timeframe, we were able to assemble a remarkable team of anesthesiologists and CRNAs,” says Scott E. Harper, M.D., division director. “The group has been able to improve patient care and OR efficiency, growing surgical volume by almost 20% in less than a year.”

Harper credits leaders within the division for the success of expanding services. These include

Mark Fannin, M.D., who stepped in and volunteered to lead the new team at St. Vincent’s East; and Ben Sutlive, M.D., who became the new chief of anesthesiology at St. Vincent’s Birmingham and is helping to guide this very large group in successful operations and recruitment.

“Looking ahead, we are focusing on building out the manpower in our division and preparing for future ventures as part of the UAB Medicine and St. Vincent’s alliance,” Harper says. “We are also excited to begin hosting a resident each month to enhance the department’s educational goals and introduce them to a rapidly paced private practice-type setting.”

NEW SCRUB CAPS

If you see a member of our anesthesia care team (ACT) wearing these UAB Medicine scrub caps, you may wonder what the patch means. Our new scrub cap is not just a head covering; it’s a symbol of our providers’ outstanding patient care and dedication to the team.

RED STAR OF LIFE:

Traditionally used in the emergency medical field, this star represents the emergent and everready stance of our ACT.

MOTTO “EVER VIGILANT”:

Vigilance is the key trait that defines our excellent anesthesia providers. It also defines the caretaker, the shepherd, the steward of patient safety, and advocacy.

GOAL “ONE TEAM, ONE MISSION”:

Our ACT operates under the umbrella of one mission as one team with unity of purpose. It is made up of faculty physicians, certified registered nurse anesthetists, fellows, residents, and interns. We also have diverse specialties, including multispecialty anesthesia, intensive care, cardiac, pediatrics, regional/pain, perioperative medicine, obstetrics, transplant, trauma, and research.

THREE STARS:

The stars represent our tripartite mission of superior and compassionate clinical care, training and education, and translational research.

ROD OF ASCLEPIUS:

This symbol denotes the healing and medicinal arts.

BACKGROUND:

The white background behind the Red Star of Life is purposely the same color scheme as the Alabama state flag.

EXPANSION

CLINICAL CARE EXPANDS TO BETTER SERVE PATIENTS

In late 2021, our department expanded our Division of Community Anesthesia’s reach to include Ascension St. Vincent’s East. The expansion allows this busy community hospital to use the cutting-edge, evidence-based approach to medicine found within an academic environment.

“The strategic alliance between St. Vincent’s and UAB Medicine has given our anesthesia providers at the St. Vincent’s facilities the opportunity to work under the umbrella of UAB anesthesia,” says Scott E. Harper, M.D., division director. “The support and resources of the department have been a great benefit. We are pleased we were instrumental in introducing the concept of these institutions working together.”

The division’s services are provided at the Ascension St. Vincent’s East campus, located northeast of Birmingham near the Trussville community. Ascension St. Vincent’s East is an acute care hospital that offers many surgical specialties, providing more than 10,000 procedures annually within 12 operating rooms. The division employs 6 anesthesiologists and more than 19 CRNAs who participate in a team-based approach to provide the best possible care for Alabamians.

WOMEN OF ANESTHESIOLOGY:

LEADING THE RESIDENCY PROGRAM AND ITS SUCCESS

Each fall, hundreds of applicants from across the country go through the rigorous interview process to become a resident in the UAB Heersink School of Medicine Department of Anesthesiology and Perioperative Medicine Residency Program. The competition is fierce, and for good reason. Our anesthesiology residency program is ranked among the top programs in the nation by U.S. News & World Report, and it boasts 21 residents each year who are given the opportunity to advance in their endeavors through research, education, and clinical practice.

To see why this program is so successful and continues to grow and flourish, it’s important to recognize the leaders responsible for the intricate details of the program and the changes they have implemented to make the program stand out among its competitors.

IGNITING THE FLAME

Vice Chair for Education Susan Black, M.D., is a professor and served as program director for the anesthesiology residency program for 15 years. After completing an extensive educational background – attending the Heersink School of Medicine, serving her residency and fellowship at the Mayo Clinic, and holding faculty roles at the Mayo Clinic, Loyola University, and the University of Florida – she returned to her alma mater to lead the next generation of anesthesiologists.

During her time at UAB and as residency program director, Black has worked tirelessly to create an educational environment that is well-rounded and seeks to develop all aspects of the residents’ career goals. Success cannot happen without change, and

it’s under her leadership that many adjustments have been made to mold the program into what it is today. Some areas to credit to her leadership include:

National Recognition: Under Black’s leadership, the program has gained national attention, with residents matching from across the United States and residents finding fellowships and practice opportunities nationwide.

Program Expansion: Not only has the residency program grown to an impressive 21 residents per class, but the fellowship programs have expanded to five accredited fellowships (18 positions per year) and two unaccredited fellowships. The new clinical base year (PGY-1) has also been created, and the education leadership has expanded to include a full-time Ph.D. medical educator.

Research and Education Growth: As program director, Black developed two research tracks: Resident Mentored Research Experience Track (RMRET) and the Systematic Training in Anesthesia Research (STAR) Program. In terms of education, all trainees focus on quality improvement and patient safety, with the option to participate in a certification program leading to Certification in Medical Quality (CMQ).

Leadership Development: Black implemented the Leadership Education and Development (LEAD) Program, a unique opportunity for residents to pursue master’s degrees in Health Administration, Healthcare Quality and Safety, Public Health, and/or obtain certification in Medical Quality and Transesophageal Echocardiography during their residency. (Since its inception, 50 residents have successfully completed the LEAD Program.) She has also mentored junior faculty in leadership roles specific to education and advocated to increase recruitment for URiM (Underrepresented in Medicine) and female candidates.

Find your niche, that aspect of your profession that you enjoy, and excel at it.

— Susan Black, M.D.

— Tekuila Carter, M.D.

PASSING THE TORCH

As Black recently stepped down from her role as residency program director, she passed the torch to more-than-capable hands. Tekuila Carter, M.D., assumed the role on Sept. 1, 2021, and is looking forward to mentoring and training the next generation of anesthesiologists.

“The success of our anesthesiology residency belongs to our people,” Carter says. “Our residents and fellows are an enthusiastic, dedicated, and exceptional group.”

Carter began her career path in medical school at Meharry Medical College in Nashville, followed by her residency at the University of Virginia and Vanderbilt University, and obstetric anesthesia fellowship at Vanderbilt – where she was also a faculty member before coming to UAB in 2015. She has truly led by example during her time at UAB in many capacities, including, but not limited to:

Medical Education: Carter has served the department in many leadership capacities; most recently as the associate residency program director and simulation director for anesthesiology simulation.

Mentorship: Since coming to UAB, Carter has served others within the program – 29 medical students, 10 residents, 3 fellows, and 5 junior faculty – as a mentor. She also impacted other medical students as a lead mentor as part of the Heersink School of Medicine’s formalized Learning Community.

Community Involvement: Carter has carried her leadership expertise into the community as well. She served on the Young Professional Board for the UAB Minority Health & Health Disparities Research Center, where she helped to raise funds for the Healthy Happy Kids Childhood Obesity Project. She also served as a member of the Mineral District Medical Society, an affiliate of the National Medical Association.

LIGHTING THE FUTURE OF ANESTHESIOLOGY

Both Black and Carter have shown, through their actions, leadership, and direct involvement with the department as well as the community, how vital collaboration and camaraderie with others are to creating a well-rounded, impactful education experience with the department.

For all anesthesiologists, Carter emphasizes the importance of growth and perseverance. “You never know if you can do it unless you try, and everyone needs help to be successful,” she says. “None of us are perfect, and making mistakes is part of the learning process. However, you must learn from them so that they are not repeated.”

“Learn from the anesthesiologists around you – identify aspects of their clinical practice, communication, and leadership that work well and incorporate them into your practice,” says Black when offering words of wisdom for other anesthesiologists. “Find your niche, that aspect of your profession that you enjoy, and excel at it.”

You never know if you can do it unless you try, and everyone needs help to be successful.

Dr. Tekuila Carter (left) and Dr. Susan Black (right)

RECRUITING IN A VIRTUAL WORLD

Living through the challenges of a global pandemic has affected all facets of department operations, and resident and fellow recruitment is no exception. Each year, hundreds of prospects interview with the department in hopes of securing one of 21 residency positions per class and 16 fellowship positions. But when the world gets put on hold, how do you show the next generation of anesthesiologists what our program, and our city, have to offer?

This is where Residency Program Director Tekuila Carter, M.D., and residing resident recruitment directors step in. Collaboratively, they devise a plan that includes virtual interviews and meet and greets, introductory videos with leaders, online resources, and a booklet containing messages from leadership, details on specialties and opportunities, and highlights about Birmingham and its surrounding communities.

“With virtual recruitment, our goal is to recreate the in-person experience as much as possible and show applicants a glimpse into our program and tight-knit community,” says Resident Recruitment Director Paige Schroder, M.D. “We hope to virtually showcase the many reasons that UAB is an amazing place to train and why we love to call Birmingham our home.”

For more information, visit go.uab.edu/anesresidency or scan the QR code to learn about our residency and fellowship programs.

Drs. Paige Schroder (left) and Tommy Regan (right) currently serve as the department’s resident recruitment directors.

We hope to virtually showcase the many reasons that UAB is an amazing place to train and why we love to call Birmingham our home.

— Paige Schroder, M.D.

WELCOME

RESIDENCY MATCHES

Congratulations to the 21 outstanding physicians (6 females and 15 males) who matched into our Anesthesiology Residency Program and began training June 24, 2021:

Sterling Anderson, D.O. Connor Bartow, D.O. Scott Bisch, M.D. Andre Bourg, M.D. David Christopherson, M.D. Joel Conway, M.D. Harvy Freitag, M.D. Jessica Fults, MPH, M.D. Skyler Graham, M.D. Kyle Grose, M.D.

Zasmine Hymes-Green, M.D. Allison Johnson, M.D. Erin Katz, M.D. Michael Oh, D.O. Alex Olausson, M.D.

Filip Polenakovik, M.D. Rhett Reynolds, M.D. Daniel Sands, M.D. Charlotte Snook, M.D. Charlotte Streetzel, M.D. Blake Wiggins, M.S., M.D.

Auburn Edward Via College of Osteopathic Medicine

Birmingham University of Alabama at Birmingham Little Rock University of Arkansas Macon

Mercer University Gainesville University of Florida Shreveport Louisiana State University

Cincinnati University of Cincinnati Cleveland Case Western University Columbus Ohio State University Dayton Wright State University Erie Lake Erie College of Osteopathic Medicine Charleston Medical University of South Carolina Greenville

University of South Carolina

Harrogate

DeBusk College of Osteopathic Medicine

Memphis University of Tennessee Dallas University of Texas, Southwestern Galveston University of Texas Lubbock Texas Tech

CELEBRATE RESIDENT GRADUATION

The Resident Graduation Banquet brought faculty, residents, and their families together on June 25, 2021, at B&A Warehouse, to recognize their outstanding accomplishments.

Audrey Alexis Avila, M.D. Riley Stephen Camp, M.D. Christopher Nolan Carmouche, M.D. William Jared Daly, M.D. James Kyle Damron, M.D. Paige Cecile Deichmann, M.D. Cater Merrill Elliott, II, M.D.

Jacob Kyle Enslin, M.D. Brendan Patrick Feehan, M.D. John Clayton Foster, M.D. Carter Michael Galbraith, M.D. Ryan Edward Gill, M.D. Sherrie Faith Moore, M.D. Bhavika Patel, M.D.

Caroline Evers Phillips, M.D. Brandon Ryan Seaver, M.D. Martin Jacob Steine, M.D. Kurt Alan Van Wagenen, M.D. Jimmy Ricky Windham, II, M.D. Matthew Gary Witzel, M.D. Karolina Izabela Zaynakov, M.D.

GRADUATION AWARDS

16th Annual J. Antonio Aldrete, M.D., M.S., Award for Excellence in Pain Medicine

In honor of Dr. Aldrete, a worldrenowned expert in pain medicine, a prolific author, an inventor, a respected educator, and a highly skilled clinician Bhavika Patel, M.D.

3rd Annual David H. Chestnut, M.D., Award for Excellence in Obstetric Anesthesia James Damron, M.D.

22nd Annual Ray J. Defalque, M.D., Award for Outstanding Performance in Regional Anesthesia

In honor of the late Dr. Defalque, who before his retirement in 1999, was a steadfast advocate of resident education and widely known for his skill in the administration of regional anesthesia

Jake Enslin, M.D.

Outstanding Pediatric Anesthesiology Graduate Award

Caroline Phillips, M.D.

7th Annual Arthur M. Boudreaux, M.D., Quality and Patient Safety Award

Caroline Phillips, M.D.

Outstanding Graduate Caroline Phillips, M.D.

LEADERSHIP, EDUCATION, AND DEVELOPMENT (LEAD) PROGRAM AWARDS

Master of Science in Healthcare Quality and Safety (MSHQS)

Caroline Phillips, M.D.

Medical Quality and Patient Safety (CMQ)

For completing the Medical Quality and Patient Safety Certification Program

Paige Deichmann, M.D. Jake Enslin, M.D.

National Board of Echocardiography Basic Certificate Program

For completing the Echocardiography Certification Program

Audrey Avila, M.D. Brendan Feehan, M.D. John Foster, M.D. Martin Steine, M.D. Kurt Van Wagenen, M.D.

Teacher of the Year 2020-2021 Recipient: Promil Kukreja, M.D.

First Runner-Up: Ben Tuck, M.D.

Second Runner-Up: Mark Powell, M.D.

Additional Top Teachers: Joseph Babcock, M.D.; Andrew Barker, M.D.; Susan Black, M.D.; Elizabeth Duggan, M.D.; Joel Feinstein, M.D.; John Huidekoper, M.D.; Prentiss Lawson, M.D.;

Domagoj Mladinov, M.D.; Bert Pierce, M.D.; Roland Short, M.D.; Brant Wagener, M.D., Ph.D.

CONGRATS

2021 FELLOWSHIP MATCHES

Adult Cardiothoracic

Joseph Patrick Babcock, M.D. Riley Stephen Camp, M.D. Jacob Kyle Enslin, M.D. Ryan Edward Gill, M.D. Martin Jacob Steine, M.D.

Critical Care Medicine

Alexander Mark Busko, M.D.

Carter Michael Galbraith, M.D. Emily Anne Wasson, M.D. Brett Tyler Wahlgren, M.D.

Pain Medicine

Dustin James Duracher, M.D. Arfan M. Qureshi, D.O. Scott Patrick Rooney, M.D. Jimmy Ricky Windham, II, M.D.

Pediatric Caroline Evers Phillips, M.D.

2021 FELLOW GRADUATES

Adult Cardiothoracic

Zachary Aaron Colbaugh, M.D. Patrick Thomas Hussey, M.D. Brooke Lanier LeBlanc, M.D. Christopher Lee Racine, M.D. Katherine Elizabeth Talbott, M.D.

Critical Care Medicine

Jesse Alex Guerena, M.D. Joseph Blake Norman, M.D. Winfred Scilla Tovar, M.D.

Obstetric

Hanna Hussey, M.D.

Pain Medicine

Christopher Lee Anderson, M.D. Patricia Cowley Doerr, M.D.

Lisa Marie Koplik-Nieves, M.D. Taylor Sanders Scruggs, M.D.

Pediatric

Lauren Rae Myers, M.D.

Regional

Teresa Marie Northern, M.D. Research

Dylan Robert Addis, M.D.

MATALON:

RESEARCH, BUILDING COMMUNITY, AND SHAPING THE FUTURE OF ANESTHESIA

Sadis Matalon, Ph.D., Dr.Sc. (Hon.), FAPS, Distinguished Professor, Alice McNeal Chair in Anesthesiology, Director of the UAB Pulmonary Injury and Repair Center, and Vice Chair for Research, is no stranger to receiving recognition for his outstanding achievements. In 2021, he was elected Corresponding Member to the Academy of Athens (the National Academy of Athens) –a coveted recognition by scientists. He has also been selected for the Lifetime Achievement Award from the Division of Terrorism and Inhalation Disasters for the American Thoracic Society.

“Dr. Matalon is a world-renowned physiologist whose research has touched countless lives,” says MB BCh, Alfred Habeeb Professor and Chair of the UAB Heersink Department of Anesthesiology and Perioperative Medicine. “He continues to be a dedicated and eager leader for our department and the UAB

ADVANCING RESEARCH THROUGH COLLABORATION

As a founder of the UAB Pulmonary Injury and Repair Center, Matalon stresses the importance of centers for academia. Currently, the Matalon lab is focusing on identifying the mechanisms by which halogens (such as chlorine) damage the cardiorespiratory system of animals and developing countermeasures; which, when administered post exposure, decrease the onset of acute and chronic lung injury. He serves as the Principal Investigator of a R21 as well as co-investigator in various grants funded by the National Institutes of Health (NIH) and a subcontract from the University of Pennsylvania funded by the Biomedical Advanced Research and Development Authority.

His reach goes beyond just the UAB community: He currently serves as editor-in-chief for Physiological Reviews – the most cited journal in the field of physiology and among the 50 most cited peer-reviewed journals –where he helps shape the field of science and hopes to continue leading the journal down a path of excellence in physiological and biomedical sciences.

Matalon boasts the department has three editors-inchief (EIC). Jean-Francois Pittet, M.D., serves as EIC of Anesthesia and Analgesia, a highly prestigious clinical journal in the field of anesthesiology. Jianguo Gu, M.B., Ph.D., serves as EIC of Molecular Pain, which publishes authoritative articles on the mechanisms of pain.

In 2021, the department had a total of 90 publications, and Matalon has been a leader and mentor for several of these publications.

Recently, he has worked alongside Aftab Ahmad, Ph.D., Shama Ahmad, Ph.D., Saurabh Aggarwal, M.D., Ph.D., Ahmed Lazrak, Ph.D., Tamas Jilling, M.D., Dylan Addis, M.D., Ammar (Saadoon) Alishlash, M.D., Gu, James Mobley, Ph.D., and other faculty to facilitate the research mission of the department’s Division of Molecular and Translational Biomedicine, which he directs. Thanks to the hard work of the faculty of this division, the department is No. 14 among other anesthesia departments funded by the NIH, and Matalon’s goal is to break into the top 10.

These valuable collaborations allow for the creation of strong, focused research centers giving way for teamwork, innovation, and discovery. Matalon believes that building a stronger infrastructure, encouraging teamwork, and reinforcing the robust UAB community is key to future-proofing the department.

“Being vice chair has taught me to be humble, work effectively with others, learn from the knowledge base of others, and appreciate new technology,” he says.

WHAT’S NEXT?

This year has been quite monumental for Matalon, and we have to wonder what is next. For starters, he is enthusiastic about continuing to pursue his research, mentoring, and leading in the department. Currently, the competitive renewal of his R01, which has been funded for 28 years, was favorably reviewed by the NIH and will be funded for 4-5 years beginning in October 2022. He also is working with a Canadian Biodefense company to develop recombinant proteins for the treatment of chemically induced acute and chronic lung injury. In addition, he is mentoring three young faculty members.

“What we are doing – it’s like the space program. In the process of getting to the moon, we developed technologies that could be used in a lot of other ways. The agents we developed can be used to treat a number of other diseases,” Matalon says. “Science is not a lone wolf telling people what to do; science is a group of people that work effectively together with complimentary expertise, willing to learn from each other. This is what drives me.”

—

Sadis Matalon, Ph.D., Dr.Sc. (Hon.), FAPS

Scientist Shubham Dubey examines the effects of halogens, such as chlorine, on the lungs.

Science is not a lone wolf telling people what to do; science is a group of people that work effectively together with complimentary expertise, willing to learn from each other.

2021 PEERREVIEWED ARTICLES, BOOKS, AND BOOK CHAPTERS

Light-Mediated Inhibition of Colonic Smooth Muscle Constriction and Colonic Motility via Opsin 3. Dan W, Park GH, Vemaraju S, Wu AD, Perez K, Rao M, Berkowitz DE , Lang RA, Yim PD.

Front Physiol. 2021 Dec 16;12:744294. doi: 10.3389/fphys.2021.744294. eCollection 2021. PMID: 34975518

Cerebral Perfusion and Sensory Testing Results Differ in Interstitial Cystitis/Bladder Pain Syndrome Patients with and without Fibromyalgia: A Site-Specific MAPP Network Study.

Deutsch G, Deshpande H, Lai HH, Kutch JJ, Ness TJ J Pain Res. 2021 Dec 23;14:3887-3895. doi: 10.2147/JPR.S343695. eCollection 2021.

PMID: 34992450

Extracellular Vesicles From Women With Severe Preeclampsia Impair Vascular Endothelial Function. Murugesan S, Hussey H, Saravanakumar L , Sinkey RG, Sturdivant AB, Powell MF, Berkowitz DE. Anesth Analg. 2021 Dec 6. doi: 10.1213/ ANE.0000000000005812. Online ahead of print.

PMID: 34871190

Implementation of App-Based Diabetes Medication Management: Outpatient and Perioperative Clinical Decision Support. Jang J, Colletti AA, Ricklefs C, Snyder HJ, Kardonsky K, Duggan EW, Umpierrez GE, O’Reilly-Shah VN. Curr Diab Rep. 2021 Dec 13;21(12):50. doi: 10.1007/s11892-021-01421-4.

PMID: 34902056

Cytotoxic tau released from lung microvascular endothelial cells upon infection with Pseudomonas aeruginosa promotes neuronal tauopathy.

Choi CS, Gwin M, Voth S, Kolb C, Zhou C, Nelson AR, deWeever A, Koloteva A, Annamdevula NS, Murphy JM, Wagener BM, Pittet JF, Lim SS, Balczon R, Stevens T, Lin MT. J Biol Chem. 2021 Dec 8;298(1):101482. doi: 10.1016/j.jbc.2021.101482. Online ahead of print.

PMID: 34896150

The Role of Cetirizine in the Changing Landscape of IV Antihistamines: A Narrative Review.

Blaiss MS, Bernstein JA, Kessler A , Pines JM, Camargo CA Jr, Fulgham P, Haumschild R, Rupp K, Tyler T, Moellman J.

Adv Ther. 2021 Dec 4:1-15. doi: 10.1007/ s12325-021-01999-x. Online ahead of print.

PMID: 34862952

Intraoperative utilisation of high-resolution data for cerebral autoregulation: a feasibility study.

Melvin RL , Abella JR, Patel R, Hagood JM, Berkowitz DE, Mladinov D.

Br J Anaesth. 2021 Dec 3:S00070912(21)00708-X. doi: 10.1016/j. bja.2021.10.035. Online ahead of print.

PMID: 34872719

Spinal neurochemical mechanisms of acute stress-induced visceral hypersensitivity in healthy rats.

Ness TJ, DeWitte C, DeBerry JJ. Neurosci Lett. 2021 Dec 17;770:136401. doi: 10.1016/j.neulet.2021.136401.

Online ahead of print.

PMID: 34929317

Patient survival following third time liver transplant in the United States in the MELD era.

He K, Sheikh SS, Orandi BJ, Smith B, Locke JE, Cannon RM.

Am J Surg. 2021 Nov 14:S00029610(21)00662-0. doi: 10.1016/j. amjsurg.2021.10.043. Online ahead of print.

PMID: 34809906

Massive transfusion and severe blood shortages: establishing and implementing predictors of futility. Mladinov D, Frank SM. Br J Anaesth. 2021 Nov 15:S00070912(21)00660-7. doi: 10.1016/j. bja.2021.10.013. Online ahead of print.

PMID: 34794769

The Role of Pseudomonas aeruginosa Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction.

Wagener BM, Hu R, Wu S, Pittet JF, Ding Q, Che P. Toxins (Basel). 2021 Nov 2;13(11):776. doi: 10.3390/toxins13110776.

PMID: 34822560

Enablers and Barriers to Multicenter Perioperative Handoff Collaboration: Lessons Learned From a Successful Model Outside the Operating Room.

Michael MM, Ambardekar AP, Pukenas E, Karamchandani K, Nguyen H, Potestio CP, Tubinis MD, Huang NR, Riesenberg LA.

Anesth Analg. 2021 Nov 1;133(5):1358-1363. doi: 10.1213/ ANE.0000000000005724.

PMID: 34673728

Hemodynamic Instability Resulting From Pseudomalfunction of a Leadless Pacemaker During Off-Pump Coronary Artery Bypass Grafting.

Brad Meers J, Snyder SW, Hasan R, Zheng Y, Davies J, Zaky A J Cardiothorac Vasc Anesth. 2021 Nov 1:S1053-0770(21)00956-3. doi: 10.1053/j.jvca.2021.10.038. Online ahead of print.

PMID: 34895966

Retrospective Case Series Comparing the Efficacy of Thoracic Epidural With Continuous Paravertebral and Erector Spinae Plane Blocks for Postoperative Analgesia After Thoracic Surgery.

Kukreja P, Herberg TJ, Johnson BM, Kofskey AM, Short RT, MacBeth L, Paul C, Kalagara H. Cureus. 2021 Oct 6;13(10):e18533. doi: 10.7759/cureus.18533. eCollection 2021 Oct.

PMID: 34754683

The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights from 2021.

Martin AK, Feinman JW, Bhatt HV, Subramani S, Malhotra AK, Townsley MM , Fritz AV, Sharma A, Patel SJ, Zhou EY, Owen RM, Ghofaily LA, Read SN, Teixeira MT, Arora L, Jayaraman AL, Weiner MM, Ramakrishna H. J Cardiothorac Vasc Anesth. 2021 Oct 15:S1053-0770(21)00931-9. doi: 10.1053/j.jvca.2021.10.011. Online ahead of print.

PMID: 34801393

Systemic and intrathecal baclofen produce bladder antinociception in rats.

Ness TJ, Randich A, Su X, DeWitte C, Hildebrand K. BMC Urol. 2021 Oct 4;21(1):139. doi: 10.1186/s12894-021-00899-0. PMID: 34607587

Mnemnonic Discrimination Deficits in First Episode Psychosis and a Ketamine Model Suggests Dentate Gyrus Pathology Linked to NMDA-Receptor Hypofunction.

Kraguljac NV, Carle M, Frölich MA , Tran S, Yassa MA, White DM, Reddy A, Lahti AC.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Oct 11:S24519022(21)00261-5. doi: 10.1016/j. bpsc.2021.09.008. Online ahead of print.

PMID: 34649019

Focused Cardiac Ultrasound in the Operating Room-Another Important Tool for the Assessment of the Unstable Patient. Markin NW, Coker BJ, Tuck BC, Chacon MM.

Anesth Analg. 2021 Oct 1;133(4):848-851. doi: 10.1213/ ANE.0000000000005487.

PMID: 34524984

The International Anesthesia Research Society Coronavirus Disease 2019

Pandemic Scientific Advisory Board: Supporting a Pandemic of Positivity. Orser BA, Jones KA

Anesth Analg. 2021 Oct 1;133(4):903-905. doi: 10.1213/

ANE.0000000000005722.

PMID: 34524988

Phosphodiesterase 4 mediates interleukin-8-induced heterologous desensitization of the β2 -adrenergic receptor.

Rich TC, Leavesley SJ, Brandon AP, Evans CA , Raju SV, Wagener BM.

FASEB J. 2021 Oct;35(10):e21946. doi: 10.1096/fj.202002712RR.

PMID: 34555226

Deciphering the Role of microRNAs in Large-Artery Stiffness Associated With Aging: Focus on miR-181b.

Baraban JM, Tuday E, Berkowitz DE Das S.

Front Physiol. 2021 Sep 27;12:747789. doi: 10.3389/fphys.2021.747789. eCollection 2021.

PMID: 34646165

Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells.

Chanda D, Rehan M, Smith SR, Dsouza KG, Wang Y, Bernard K, Kurundkar D, Memula V, Kojima K, Mobley JA Benavides GA, Darley-Usmar V, Kim YI, Zmijewski JW, Deshane JS, De Langhe S, Thannickal VJ. Elife. 2021 Sep 16;10:e68049. doi: 10.7554/eLife.68049. PMID: 34528872

Local SARS-CoV-2 peptide-specific Immune Responses in Convalescent and Uninfected Human Lung Tissue Models.

Goliwas KF, Simmons CS, Khan SA, Wood AM, Wang Y, Berry JL, Athar M, Mobley JA , Kim YI, Thannickal VJ, Harrod KS, Donahue JM, Deshane JS. medRxiv. 2021 Sep 6:2021.09.02.21263042. doi:10.1101/2 021.09.02.21263042. Preprint. PMID: 34518842

Biomarkers for Adverse Lung Injury Following Pediatric Cardiopulmonary Bypass.

Asfari A, Hock KM, Byrnes JW, Borasino S, Halloran BA, Mobley JA , Ambalavanan N. Crit Care Explor. 2021 Sep 7;3(9):e0528. doi: 10.1097/ CCE.0000000000000528. eCollection 2021 Sep. PMID: 34514425

CaMK4 Is a Downstream Effector of the α1G T-type Calcium Channel to Determine the Angiogenic Potential of Pulmonary Microvascular Endothelial Cells.

Zheng Z , Wang X, Wang Y, King JAC, Xie P, Wu S

Am J Physiol Cell Physiol. 2021 Sep 29. doi: 10.1152/ajpcell.00216.2021. Online ahead of print.

PMID: 34586897

Pneumonia initiates a tauopathy. Balczon R, Lin MT, Lee JY, Abbasi A, Renema P, Voth SB, Zhou C, Koloteva A, Michael Francis C, Sodha NR, Pittet JF, Wagener BM , Bell J, Choi CS, Ventetuolo CE, Stevens T. FASEB J. 2021 Sep;35(9):e21807. doi: 10.1096/fj.202100718R.

PMID: 34384141

Halogen-Induced Chemical Injury to the Mammalian Cardiopulmonary Systems.

Addis DR, Aggarwal S, Lazrak A, Jilling T, Matalon S. Physiology (Bethesda). 2021 Sep 1;36(5):272-291. doi: 10.1152/ physiol.00004.2021.

PMID: 34431415

Degradation of Premature-miR-181b by the Translin/Trax RNase Increases Vascular Smooth Muscle Cell Stiffness. Tuday E, Nakano M, Akiyoshi K, Fu X, Shah AP, Yamaguchi A, Steenbergen C, Santhanam L, An SS, Berkowitz D Baraban JM, Das S. Hypertension. 2021 Sep;78(3):831-839. doi: 10.1161/ HYPERTENSIONAHA.120.16690. Epub 2021 Jul 26.

PMID: 34304585

Do oropharyngeal throat packs prevent fluid ingestion during orthognathic surgery?

Powell K, Amin D, Sesanto R, Bryant A, Kukreja P, Waite P. Int J Oral Maxillofac Surg. 2021 Aug 5:S0901-5027(21)00261-7. doi: 10.1016/j.ijom.2021.07.011. Online ahead of print.

PMID: 34366208

Incremental Value of Live/Real-Time Three-Dimensional Transesophageal Echocardiography Over the TwoDimensional Technique in the Identification of Accessory Liver Lobe Presenting as a Right Atrial Mass. Nooli NP, Vardas P, Koguru Y, Nanda NC.

J Cardiothorac Vasc Anesth. 2021 Aug 9:S1053-0770(21)00679-0. doi: 10.1053/j.jvca.2021.08.007. Online ahead of print.

PMID: 34521579

Point-of-Care Ultrasound (POCUS) Training for Anesthesiologists: Is it Time to Embrace and Attain Competency?

Kalagara H, Manson W, Townsley MM

J Cardiothorac Vasc Anesth. 2021 Aug 14:S1053-0770(21)00685-6. doi: 10.1053/j.jvca.2021.08.013. Online ahead of print.

PMID: 34521580

Effects of cooling temperatures via thermal K2P channels on regeneration of high-frequency action potentials at nodes of Ranvier of rat A β-afferent nerves.

Kanda H , Tonomura S, Gu JG eNeuro. 2021 Aug 27:ENEURO.0308-21.2021. doi: 10.1523/ENEURO.0308-21.2021. Online ahead of print.

PMID: 34462308

Single-Dose Intranasal Administration of AdCOVID Elicits Systemic and Mucosal Immunity against SARS-CoV-2 and Fully Protects Mice from Lethal Challenge.

King RG, Silva-Sanchez A, Peel JN, Botta D, Dickson AM, Pinto AK, Meza-Perez S, Allie SR, Schultz MD, Liu M, Bradley JE, Qiu S, Yang G, Zhou F, Zumaquero E, Simpler TS, Mousseau B, Killian JT Jr, Dean B, Shang Q, Tipper JL , Risley CA, Harrod KS, Feng T, Lee Y, Shiberu B, Krishnan V, Peguillet I, Zhang J, Green TJ, Randall TD, Suschak JJ, Georges B, Brien JD, Lund FE, Roberts MS.

Vaccines (Basel). 2021 Aug 9;9(8):881. doi: 10.3390/vaccines9080881.

PMID: 34452006

In celebration of the 100th Anniversary of Physiological Reviews. Matalon S

Physiol Rev. 2021 Aug 30. doi: 10.1152/ physrev.00032.2021. Online ahead of print.

PMID: 34459221

Effects of acute normovolemic hemodilution on post-cardiopulmonary bypass coagulation tests and allogeneic blood transfusion in thoracic aortic repair surgery: An observational cohort study.

Mladinov D, Eudailey KW, Padilla LA, Norman JB, Leahy B, Enslin J, Parker K, Cornelius KF, Davies JE.

J Card Surg. 2021 Aug 24. doi: 10.1111/ jocs.15943. Online ahead of print.

PMID: 34431128

Adaptations in anesthesiology residency programs amid the COVID-19 pandemic: virtual approaches to applicant recruitment. Lee DC, Kofskey AM, Singh NP, King TW, Piennette PD

BMC Med Educ. 2021 Aug 31;21(1):464. doi: 10.1186/s12909-021-02895-2.

LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen species. Cho DY, Zhang S, Lazrak A, Skinner D, Thompson HM, Grayson J, Guroji P, Aggarwal S, Bebok Z, Rowe SM, Matalon S, Sorscher EJ, Woodworth BA. Redox Biol. 2021 Jul;43:101998. doi: 10.1016/j.redox.2021.101998. Epub 2021 Apr 30.

PMID: 33971543

Perioperative Implications of the 2020 American Heart Association/American College of Cardiology Guidelines for the Diagnosis and Treatment of Patients with Hypertrophic Cardiomyopathy: A Focused Review. Addis DR, Townsley MM

J Cardiothorac Vasc Anesth. 2021 Jul 16:S1053-0770(21)00605-4. doi: 10.1053/j.jvca.2021.07.024. Online ahead of print.

PMID: 34373182

Comparison of Genicular Nerve Block in Combination with Adductor Canal Block in Both Primary and Revision Total Knee Arthroplasty: A Retrospective Case Series. Kukreja P, Venter A , Mason L, Kofskey AM, Northern T, Naranje S, Ghanem E, Lawson PA, Kalagara H Cureus. 2021 Jul 29;13(7):e16712. doi: 10.7759/cureus.16712. eCollection 2021 Jul.

PMID: 34471571

Echocardiographic, Biochemical, and Electrocardiographic Correlates Associated With Progressive Pulmonary Arterial Hypertension. Zaky A, Zafar I, Masjoan-Juncos JX, Husain M, Mariappan N, Morgan CJ, Hamid T, Frölich MA, Ahmad S, Ahmad A Front Cardiovasc Med. 2021 Jul 20;8:705666. doi: 10.3389/ fcvm.2021.705666. eCollection 2021. PMID: 34355033

Water-soluble tocopherol derivatives inhibit SARS-CoV-2 RNA-dependent RNA polymerase.

Pacl HT, Tipper JL, Sevalkar RR, Crouse A, Crowder C; UAB Precision Medicine Institute, Ahmad S, Ahmad A , Holder GD, Kuhlman CJ, Chinta KC, Nadeem S, Green TJ, Petit CM, Steyn AJC, Might M, Harrod KS. bioRxiv. 2021 Jul 27:2021.07.13.449251. doi: 10.1101/2021.07.13.449251. Preprint.

PMID: 34282419

A comprehensive study of a 29-capsid AAV library in a non-human primate central nervous system.

Kondratov O, Kondratova L, Mandel RJ, Coleman K, Savage MA, Gray-Edwards HL, Ness TJ, Rodriguez-Lebron E, Bell RD, Rabinowitz J, Gamlin PD, Zolotukhin S.

Mol Ther. 2021 Jul 21:S15250016(21)00364-6. doi: 10.1016/j. ymthe.2021.07.010. Online ahead of print.

PMID: 34298128

Fibrinolytic or anti-plasmin (nafamostat) therapy for COVID-19: A timing challenge for clinicians.

Ji HL, Wagener BM, Ness TJ, Zhao R. Pulm Pharmacol Ther. 2021 Jul 13;70:102055. doi: 10.1016/j. pupt.2021.102055. Online ahead of print.

PMID: 34271164

Carbonic Anhydrase IX and Hypoxia Promote Rat Pulmonary Endothelial Cell Survival During Infection.

Lee JY, Stevens RP, Kash M, Alexeyev MF, Balczon R, Zhou C, Renema P, Koloteva A, Kozhukhar N, Pastukh V, Gwin MS, Voth S, deWeever A, Wagener BM, Pittet JF, Eslaamizaad Y, Siddiqui W, Nawaz T, Clarke C, Fouty BW, Audia JP, Alvarez DF, Stevens T.

Am J Respir Cell Mol Biol. 2021 Jul 12. doi: 10.1165/rcmb.2020-0537OC. Online ahead of print.

PMID: 34251286

LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen species.

Cho DY, Zhang S, Lazrak A , Skinner D, Thompson HM, Grayson J, Guroji P, Aggarwal S, Bebok Z, Rowe SM, Matalon S, Sorscher EJ, Woodworth BA. Redox Biol. 2021 Jul;43:101998. doi: 10.1016/j.redox.2021.101998. Epub 2021 Apr 30.

PMID: 33971543

Does the Retromolar Area Provide Adequate Space for an Oral Endotracheal Tube without Interfering with Intermaxillary Fixation?

Sittitavornwong S, Mostofi P, DiLuzio K, Kukreja P, Deatherage H, Kukreja P. J Oral Maxillofac Surg. 2021 Jun 12:S0278-2391(21)00548-6. doi: 10.1016/j.joms.2021.06.011. Online ahead of print.

PMID: 34256021

Behavioral and Neuronal Effects of Inhaled Bromine Gas: Oxidative Brain Stem Damage.

Shakil S, Masjoan Juncos JX, Mariappan N, Zafar I, Amudhan A, Amudhan S, Aishah D, Siddiqui S, Manzoor S, Santana CM, Rumbeiha WK, Salim S, Ahmad A, Ahmad S. Int J Mol Sci. 2021 Jun 12;22(12):6316. doi: 10.3390/ijms22126316. PMID: 34204780

Development of An Individualized Risk Prediction Model for COVID-19 Using Electronic Health Record Data.

Mamidi TKK, Tran-Nguyen TK, Melvin RL , Worthey EA.

Front Big Data. 2021 Jun 4;4:675882. doi: 10.3389/fdata.2021.675882.

eCollection 2021.

PMID: 34151259

AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1. Ahmad I, Molyvdas A, Jian MY, Zhou T, Traylor AM, Cui H, Liu G, Song W, Agarwal A , Jilling T, Aggarwal S, Matalon S. Eur Respir J. 2021 May 28:2003694. doi: 10.1183/13993003.03694-2020.

Online ahead of print.

PMID: 34049949

Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexin.

Alishlash AS, Sapkota M, Ahmad I, Maclin K, Ahmed NA, Molyvdas A, Doran S, Albert CJ, Aggarwal S, Ford DA, Ambalavanan N, Jilling T, Matalon

S

Redox Biol. 2021 May 17;44:102009. doi: 10.1016/j.redox.2021.102009.

Online ahead of print.

PMID: 34044323

Efficacy and Safety of Drug Combinations for Chronic Pelvic Pain: Protocol for a Systematic Review. Mohiuddin M, Park R, Wesselmann U, Pukall C, Jarvi K, Nickel C, Doiron C, Gilron I.JMIR Res Protoc. 2021 May 17;10(5):e21909. doi: 10.2196/21909.

PMID: 33999006

Benefits of the enhanced recovery after surgery pathway for orthognathic surgery.

Stratton M, Waite PD, Powell KK, Scopel MM, Kukreja P. Int J Oral Maxillofac Surg. 2021 May 6:S09015027(21)00161-2. doi: 10.1016/j. ijom.2021.04.008. Online ahead of print.

PMID: 33966966

NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns.

Surolia R, Li FJ, Wang Z, Kashyap M, Srivastava RK, Traylor AM, Singh P, Dsouza KG, Kim H, Pittet JF, Zmijewski JW, Agarwal A, Athar M, Ahmad A Antony VB. JCI Insight. 2021 May 24;6(10):147564. doi: 10.1172/jci. insight.147564.

PMID: 34027893

Comparing traditional, immersive simulation with Rapid Cycle Deliberate Practice in postgraduate year 2 anesthesiology residents.

Blanchard EE, Riesenberg LA, Bergman LB, Brown MR, O’Hagan EC, Patel SJ, Carter TR. Adv Simul (Lond). 2021 May 26;6(1):20. doi: 10.1186/s41077-02100174-0.

PMID: 34039446

A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure.

Langley RJ, Migaud ME, Flores L, Thompson JW, Kean EA, Mostellar MM, Mowry M, Luckett P, Purcell LD, Lovato J, Gandotra S, Benton R, Files DC, Harrod KS, Gillespie MN, Morris PE. Sci Rep. 2021 May 18;11(1):10515. doi: 10.1038/ s41598-021-89716-0.

PMID: 34006901

Incidence and Predictors of Early and Delayed Renal Function Decline After Aortic Aneurysm Repair in the Vascular Quality Initiative Database.

Novak Z, Zaky A , Spangler EL, McFarland GE, Towani A, Beck AW.J Vasc Surg. 2021 May 18:S07415214(21)00729-1. doi: 10.1016/j. jvs.2021.04.049. Online ahead of print.

PMID: 34019992

Patient monitoring in the nonoperating room anesthesia (NORA) setting: current advances in technology. Routman J, Boggs SD. Curr Opin Anaesthesiol. 2021 May 18. doi: 10.1097/ACO.0000000000001012. Online ahead of print.

PMID: 34010175

Diagnostic Point-of-Care Ultrasound: Recommendations From an Expert Panel.

Bronshteyn YS, Anderson TA, Badakhsh O, Boublik J, Brady MBW, Charnin JE, Coker BJ, Deriy LB, Hardman HD, Haskins SC, Hollon M, Hsia HJ, Neelankavil JP, Panzer OPF, Perlas A, Ramsingh D, Sharma A, Shore-Lesserson LJ, Zimmerman JM; American Society of Anesthesiologists Ad Hoc Committee on PoCUS. J Cardiothorac Vasc Anesth. 2021 Apr 17:S1053-0770(21)00342-6. doi: 10.1053/j.jvca.2021.04.016. Online ahead of print.

PMID: 34059438

Identification of novel bladder sensory GPCRs.

Smith TA, Moore BN, Matoso A, Berkowitz DE, DeBerry JJ, Pluznick JL. Physiol Rep. 2021 Apr;9(8):e14840. doi: 10.14814/phy2.14840.

PMID: 33932109

A Placebo-Controlled, PseudoRandomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum).

Younger J, Donovan EK, Hodgin KS, Ness TJ Int J Environ Res Public Health. 2021 Apr 1;18(7):3671. doi: 10.3390/ ijerph18073671. PMID: 33915962

Visualization and Identification of Bioorthogonally Labeled Exosome Proteins Following Systemic Administration in Mice.

Zhang E, Liu Y, Han C, Fan C, Wang L, Chen W, Du Y, Han D, Arnone B, Xu S, Wei Y, Mobley J, Qin G. Front Cell Dev Biol. 2021 Apr 7;9:657456. doi: 10.3389/ fcell.2021.657456. eCollection 2021. PMID: 33898459

Influenza Antiviral Subversion: Now the Host is in on the Act. Yepsen EN, Harrod KS. Am J Respir Cell Mol Biol. 2021 Apr 13. doi: 10.1165/ rcmb.2021-0094ED. Online ahead of print.

PMID: 33848230

Longitudinal Associations of Fitness and Obesity in Young Adulthood with Right Ventricular Function and Pulmonary Artery Systolic Pressure in Middle Age: The CARDIA Study. Patel KV, Metzinger M, Park B, Allen N, Ayers C, Kawut SM, Sidney S, Goff DC Jr, Jacobs DR Jr, Zaky AF, Carnethon M, Berry JD, Pandey A. J Am Heart Assoc. 2021 Apr 6;10(7):e016968. doi: 10.1161/ JAHA.120.016968. Epub 2021 Mar 28. PMID: 33775106

The Anterior Mediastinal Massthe Challenging Management of Hypoxemia Despite Peripheral Cannulation for ECMO.

Juan IC, Poorsattar SP, Banks DA, O’Brien EO, Fernando RJ, Addis D, Augoustides JG, Shah RM, Thistlethwaite PA. J Cardiothorac Vasc Anesth. 2021 Mar 6:S10530770(21)00198-1. doi: 10.1053/j. jvca.2021.03.003. Online ahead of print.

PMID: 33865684

Vaping and E-Cigarette Use in Children and Adolescents: Implications on Perioperative Care From the American Society of Anesthesiologists Committee on Pediatric Anesthesia, Society for Pediatric Anesthesia, and American Academy of Pediatrics Section on Anesthesiology and Pain Medicine.

Rusy DA, Honkanen A, Landrigan-Ossar MF, Chatterjee D, Schwartz LI, Lalwani K, Dollar JR, Clark R, Diaz CD, Deutsch N, Warner DO, Soriano SG.

Anesth Analg. 2021 Mar 29. doi: 10.1213/ANE.0000000000005519. Online ahead of print.

PMID: 33780391

Improving Adherence to Intraoperative Lung-Protective Ventilation Strategies Using Near Real-Time Feedback and Individualized Electronic Reporting.

Parks DA, Short RT, McArdle PJ, Liwo A, Hagood JM, Crump SJ, Bryant AS Vetter TR, Morgan CJ, Beasley TM, Jones KA

Anesth Analg. 2021 Mar 16. doi: 10.1213/ANE.0000000000005481. Online ahead of print.

PMID: 33724961

Opportunities Beyond the Anesthesiology Department: Broader Impact Through Broader Thinking.

Mathis MR, Schonberger RB, Whitlock EL, Vogt KM, Lagorio JE, Jones KA Conroy JM, Kheterpal S. Anesth Analg. 2021 Mar 8. doi: 10.1213/ ANE.0000000000005428. Online ahead of print.

PMID: 33684091

RAC1 nitration at Y32 IS involved in the endothelial barrier disruption associated with lipopolysaccharidemediated acute lung injury.

Wang T, Yegambaram M, Gross C, Sun X, Lu Q, Wang H, Wu X, Kangath A, Tang H, Aggarwal S, Black SM. Redox Biol. 2021 Jan;38:101794. doi: 10.1016/j. redox.2020.101794. Epub 2020 Nov 13. PMID: 33248422

Management of warfarin-associated intracerebral hemorrhage before and after implementation of an order set and prospective pharmacist order verification.

Varnes BE, Singh V, May CC. J Thromb Thrombolysis. 2021 Mar 4. doi: 10.1007/s11239-021-02404-8. Online ahead of print.

PMID: 33661477

Implications of Carotid Arterial Plaque

Assessment by Ultrasound for the Cardiothoracic Anesthesiologist: An Overview of the 2020 American Society of Echocardiography

Recommendations for the Assessment of Carotid Arterial Plaque by Ultrasound for the Characterization of Atherosclerosis and Evaluation of Cardiovascular Risk.

Addis DR, Townsley MM

J Cardiothorac Vasc Anesth. 2021 Apr;35(4):987-990. doi: 10.1053/j. jvca.2020.12.006. Epub 2020 Dec 16.

PMID: 33431270

A Placebo-Controlled, PseudoRandomized, Crossover Trial of Botanical Agents for Gulf War Illness: Resveratrol (Polygonum cuspidatum), Luteolin, and Fisetin (Rhus succedanea).

Hodgin KS, Donovan EK, Kekes-Szabo S, Lin JC, Feick J, Massey RL, Ness TJ Younger JW.

Int J Environ Res Public Health. 2021 Mar 3;18(5):2483. doi: 10.3390/ ijerph18052483.

PMID: 33802381

A Placebo-Controlled, PseudoRandomized, Crossover Trial of Botanical Agents for Gulf War Illness: Curcumin (Curcuma longa), Boswellia (Boswellia serrata), and French Maritime Pine Bark (Pinus pinaster).

Donovan EK, Kekes-Szabo S, Lin JC, Massey RL, Cobb JD, Hodgin KS, Ness TJ, Hangee-Bauer C, Younger JW. Int J Environ Res Public Health. 2021 Mar 3;18(5):2468. doi: 10.3390/ ijerph18052468.

PMID: 33802272

Utilization of epidural volume extension technique for external cephalic version.

Hussey H, Damron J, Powell MF, Tubinis M . Proc (Bayl Univ Med Cent). 2021 Feb 2;34(3):422-423. doi: 10.1080/08998280.2021.1878870.

PMID: 33953486

Imaging Cardiac Amyloidosis: An Update for the Cardiothoracic Anesthesiologist.

Meers JB, Townsley MM

J Cardiothorac Vasc Anesth. 2021 Feb 19:S1053-0770(21)00174-9. doi: 10.1053/j.jvca.2021.02.040. Online ahead of print.

PMID: 33736913

Noninvasive Assessment of Right Ventricle Function and Pulmonary Artery Pressure Using Transthoracic Echocardiography in Women With PreEclampsia: An Exploratory Study.

Zaky AF, Froelich M, Meers B, Sturdivant AB, Densmore R, Subramaniam A, Carter T, Tita AN, Matalon S, Jilling T. Cureus. 2021 Feb 18;13(2):e13419. doi: 10.7759/cureus.13419.

PMID: 33763315

A 50 kdyne contusion spinal cord injury with or without the drug SS-31 was not associated with major changes in muscle mass or gene expression 14 d after injury in young male mice.

Graham ZA, DeBerry JJ, Cardozo CP, Bamman MM.

Physiol Rep. 2021 Feb;9(4):e14751. doi: 10.14814/phy2.14751.

PMID: 33611851

American Society of Regional Anesthesia and Pain Medicine expert panel recommendations on point-ofcare ultrasound education and training for regional anesthesiologists and pain physicians-part I: clinical indications.

Haskins SC, Bronshteyn Y, Perlas A, El-Boghdadly K, Zimmerman J, Silva M, Boretsky K, Chan V, Kruisselbrink R, Byrne M, Hernandez N, Boublik J, Manson WC, Hogg R, Wilkinson JN, Kalagara H , Nejim J, Ramsingh D, Shankar H, Nader A, Souza D, Narouze S.

Reg Anesth Pain Med. 2021 Feb 24:rapm-2021-102560. doi: 10.1136/ rapm-2021-102560. Online ahead of print.

PMID: 33632778

American Society of Regional Anesthesia and Pain Medicine expert panel recommendations on point-ofcare ultrasound education and training for regional anesthesiologists and pain physicians-part II: recommendations.

Haskins SC, Bronshteyn Y, Perlas A, El-Boghdadly K, Zimmerman J, Silva M, Boretsky K, Chan V, Kruisselbrink R, Byrne M, Hernandez N, Boublik J, Manson WC, Hogg R, Wilkinson JN, Kalagara H , Nejim J, Ramsingh D, Shankar H, Nader A, Souza D, Narouze S.

Reg Anesth Pain Med. 2021 Feb 24:rapm-2021-102561. doi: 10.1136/ rapm-2021-102561. Online ahead of print.

PMID: 33632777

Chitinase 3-like-1 protects airway function despite promoting type 2 inflammation during fungal-associated allergic airway inflammation. Mackel JJ, Garth JM, Jones M, Ellis DA, Blackburn JP, Yu Z, Matalon S, Curtiss M, Lund FE, Hastie AT, Meyers DA, Steele C.

Am J Physiol Lung Cell Mol Physiol. 2021 Feb 3. doi: 10.1152/ ajplung.00528.2020. Online ahead of print.

PMID: 33533316

Electrophysiological properties of maxillary trigeminal A β-afferent neurons of rats.

Okutsu Y, Yamada A, Tonomura S, Vaden RJ, Gu JG. Mol Pain. 2021 Jan-Dec;17:17448069211021271. doi: 10.1177/17448069211021271.

PMID: 34056968

Point-of-Care Ultrasound (POCUS) for the Cardiothoracic Anesthesiologist. Kalagara H, Coker B, Gerstein NS, Kukreja P, Deriy L, Pierce A, Townsley MM . J Cardiothorac Vasc Anesth. 2021 Jan 16:S1053-0770(21)00053-7. doi: 10.1053/j.jvca.2021.01.018. Online ahead of print.

PMID: 33563532

Low-Dose Dextromethorphan for the Treatment of Fibromyalgia Pain: Results from a Longitudinal, SingleBlind, Placebo-Controlled Pilot Trial. Mueller C, Ness TJ, Younger JW. J Pain Res. 2021 Jan 27;14:189-200. doi: 10.2147/JPR.S285609. eCollection 2021.

PMID: 33542651

Corrigendum to “Role of senescence marker p16INK4A measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults” [Exp. Gerontol. 74 (2016) 29-36].

Pustavoitau A, Barodka V, Sharpless NE, Torrice C, Nyhan D, Berkowitz DE , Shah AS, Bandeen Roche KJ, Walston J. Exp Gerontol. 2021 Feb;144:111217. doi: 10.1016/j.exger.2020.111217. Epub 2021 Jan 3.

PMID: 33402297

Acetate, a Short-Chain Fatty Acid, Acutely Lowers Heart Rate and Cardiac Contractility along with Blood Pressure.

Poll BG, Xu J, Jun S, Sanchez J, Zaidman N, He X, Lester L, Berkowitz D, Paolocci N, Gao WD, Pluznick

J.J. Pharmacol Exp Ther. 2021 Jan 7:JPET-AR-2020-000187. doi: 10.1124/ jpet.120.000187. Online ahead of print.

PMID: 33414131

Korean Red Ginseng aqueous extract improves markers of mucociliary clearance by stimulating chloride secretion.

Cho DY, Skinner D, Zhang S, Lazrak A, Lim DJ, Weeks CG, Banks CG, Han CK, Kim SK, Tearney GJ, Matalon S, Rowe SM, Woodworth BA.

J Ginseng Res. 2021 Jan;45(1):66-74. doi: 10.1016/j.jgr.2019.09.001. Epub 2019 Sep 13.

PMID: 33437158

Reply to Goebel and Molloy. Baranowski A, Messelink B, Wesselmann U, Häuser W. Pain. 2021 Jan;162(1):321-322. doi: 10.1097/j. pain.0000000000002132. PMID: 33323846

Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.

Ahmad S, Manzoor S, Siddiqui S, Mariappan N, Zafar I, Ahmad A, Ahmad A.

Semin Cancer Biol. 2021 Jan 20:S1044579X(21)00008-0. doi: 10.1016/j. semcancer.2021.01.003. Online ahead of print.

PMID: 33484868

PRV Editorial - Physiological Reviews: The Past, the Present and the Future. Matalon S

Physiol Rev. 2021 Jan 14. doi: 10.1152/ physrev.00001.2021. Online ahead of print.

PMID: 33444114

Protocol for pressure-clamped patchclamp recording at the node of Ranvier of rat myelinated nerves.

Kanda H, Tonomura S, Dai Y, Gu JG STAR Protoc. 2021 Jan 12;2(1):100266. doi: 10.1016/j.xpro.2020.100266. eCollection 2021 Mar 19.

PMID: 33490982

Kv4.3 channel dysfunction contributes to trigeminal neuropathic pain manifested with orofacial cold hypersensitivity in rats.

Kanda H, Ling J, Chang YT, Erol F, Viatchenko-Karpinski V, Yamada A, Noguchi K, Gu JG

J Neurosci. 2021 Jan 15:JNRM-2036-20. doi: 10.1523/ JNEUROSCI.2036-20.2021. Online ahead of print.

PMID: 33472822

EDITORS-IN-CHIEF

JIANGUO GU, M.B., PH.D. Molecular Pain

SADIS MATALON, PH.D., DR.SC. (HON.), FAPS Physiological Reviews

REINVENT

FUNDING THE FUTURE

The Research Integration Venture (REINVENT) program is a collaborative research seed funding program for faculty projects within the UAB Department of Anesthesiology and Perioperative Medicine.

The goal is to promote innovative research, encourage the integration of our clinical, basic, and translational research faculty, foster mentorship, and allocate resources (both time and money) transparently and competitively, with an eye toward future project sustainability. As a merit seed funding program, it encourages both intra- and inter-departmental collaborations and team building, availability of academic time, and financial support.

JEAN-FRANCOIS PITTET, M.D. Anesthesia and Analgesia

CONGRATULATIONS TO THE 2021 REINVENT AWARDEES!

Riaz Karukappadath, M.D.

Mitochondrial dysfunction con tributes to sepsis induced cardiac dysfunction

Ahmed Lazrak, Dr.Sc.

Epithelial ion channels expression and function regulation in pulmonary aspiration

BLUE RIDGE RANKINGS

In 2021, the Blue Ridge Institute for Medical Research ranked the UAB Heersink Department of Anesthesiology and Perioperative Medicine No. 14 in NIH funding.

SICKBAY

If you’re in the UAB Heersink Department of Anesthesiology and Perioperative Medicine, you’ve probably heard about the platform called Sickbay; a high-resolution device integration used for data capture and analysis.

Indeed, it is unique in its ability to chart and record – in a timely, synchronized fashion – any and all physiologic variables from our operating rooms’ (OR) critical care monitors and machines at high frequency. But what can we do with it?

“Sickbay allows us to not only capture signals that would otherwise be lost after being shown on a monitor, but also create new knowledge from those signals,” says Principal Data Scientist Ryan Melvin, Ph.D. “Our prime examples are calculating optimal blood pressure by estimating a patient’s ability to autoregulation cerebral blood flow, which we published recently, and estimating vascular stiffness via pulse arrival time, on which Ryan Godwin, Ph.D., from the Data Science team is working closely with Andre Gosling, M.D., and Dan Berkowitz, MB BCh.”

Currently, our department uses Sickbay exclusively in the Cardiovascular Operating Room (CVOR) and Neurological Intensive Care Unit (NICU). In the CVOR, it can be used for research purposes. While in the NICU, Sickbay can be used for remote monitoring and research.

As one example of research in the CVOR – championed by Domagoj Mladinov, M.D., Ph.D., and Berkowitz – we’re using the platform to analyze high-resolution nearinfrared spectroscopy (NIRS) and arterial blood pressure (ABP) (at 120Hz) signals to estimate patients’ lower limits of cerebral autoregulation. That is, we want to identify the optimal blood pressure for each individual patient (precision medicine and goal-directed therapy) rather than targeting blood pressure based on commonly accepted population-based standards.

Similarly, for NICU patients with intracranial pressure monitoring (ICP), we can calculate optimal blood pressure from a combination of ABP and ICP signals. Both interventions have a goal of improving brain perfusion by individualizing blood pressure and other therapies.

Find out more from the research behind Sickbay. Intraoperative utilisation of high-resolution data for cerebral autoregulation: a feasibility study. RL Melvin, JR Abella, R Patel, JM Hagood, DE Berkowitz, D Mladinov

British Journal of Anesthesia 128 (3), e217-e219

IMPROVING PATIENT CARE THROUGH CUSTOMIZED DATA

In the NICU, the platform is available for remote monitoring such as gas monitoring (example: respiratory rate), ECG signals, hemodynamics (example: arterial blood pressure), temperature, and CNS monitoring (example: EEG). It can also provide continuous up-to-the-minute information trends from a patient’s entire (monitored) stay.

Sickbay has endless capabilities and allows our physicians to use retrospective data to create risk calculators that can be viewed from anywhere you can access the internet – a highly efficient and futurethinking approach to patient care.

Relationship between CPP and autoregulation index PRx. When in an impaired state, there is a positive relationship between changes in cerebral blood flow (CBF) and mean arterial pressure (MAP). Curves use simulated data. LLA and ULA indicate the lower and upper limits of autoregulation respectively.

For more information about the Data Science team and future projects, visit go.uab.edu/anesdatascience1 or scan the QR code.

Ryan Melvin, Ph.D. Principal Data Scientist

BY THE NUMBERS

BOOK CLUB BOOKS

DIVISIONS

PROMOTIONS

ENDOWED PROFESSORS & CHAIRS

MEMBERS

RAPID REINVENT AWARDS

GRANTS

OUR CULTURE

Although more rules and restrictions were put in place, that didn’t stop our department from gathering (either virtually or safely masked) to collaborate, educate, and celebrate! Here are some of the clubs, committees, and events that we enjoyed throughout the year.

CRNA APPRECIATION WEEK

UAB WINTER COURSE IN VAIL

ANESTHESIOLOGIST

WEEK

RESIDENT APPRECIATION DAY

DAY

DAY

RESIDENT GRADUATION

RESIDENT & FELLOW WELCOME

RESIDENT RETREATS

LUNCHES

CHAT WITH THE CHAIR

CLUB

JOURNAL CLUB

EQUITY, AND INCLUSION COUNCIL

CARE TEAM

COMMITTEE

PARTY

BHAM TOP 5

You may have heard Birmingham referred to as the Magic City, and there are plenty of reasons why! In 2021, both our city and institutions earned accolades in a variety of categories. Here are five reasons that make UAB and our community so special.

BEST PLACE TO WORK

As Alabama’s largest public employer and home of one of the region’s largest academic medical centers, UAB was recognized as America’s No. 1 Best Large Employer by Forbes in 2021.

WORLD-RENOWNED

Cited for its top-notch cuisine, venues, shopping, and more, Conde Nast Traveler named Birmingham one of the best places to visit in the world in 2022.

DIVERSITY

For 2021, Forbes named UAB America’s No. 4 Best Employer for Diversity. In addition, a report from Women’s Power Gap Initiative (in partnership with the American Association of University Women) ranked UAB as a national leader in racial and gender diversity representation in leadership.

NIH FUNDING

The UAB Heersink School of Medicine is one of the top 21 NIHfunded institutions with $272 million in NIH support.

NO. 1 HOSPITAL

U.S. News & World Report placed UAB Hospital as the best hospital in Alabama in its 2021-2022 Best Hospital rankings.