Comment 173 - March 2007

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| 2 Profile 2007 | 3 Wolfson Foundation gives £4m | 5 King’s forges new links with India | 7 Defence Minister | 8 First Honorary Degree

Comment Issue no 173 | March 2007

The College newsletter

Fifth MRC Centre at King’s Greg Funnell

King’s has been awarded a new

MRC Centre for Transplantation to address some of the ongoing problems associated with transplantation. The Centre will be directed by Professor Steven Sacks and brings the total to five prestigious Medical Research Council (MRC) Centres at King’s, more than at any other institution.

More MRC Centres than at any other institution The Centre will bring together experts in basic biology and transplant medicine to focus research on delivering more rapid and effective methods of diagnosis and treatment. The programme of research will apply an extensive knowledge of human immunology, stem cell biology, genomics and imaging to develop new areas that will benefit human health. The Centre will also play a pivotal role in training and education and will work closely with the Centre for Medical Law and Ethics at King’s on the regulation and ethics of transplantation research. Replacement of diseased organs and cells by healthy tissue has partly been realised through progress in transplantation over the last 50 years. But several outstanding issues are hindering medical progress in this area. These include a shortage of donor organs, high rates of mid-term graft loss and cumulative drug toxicity.

Some of the key investigators collaborating in the new Centre. From left: Professors Robert Lechler, Ellen Solomon, Steven Sacks, Adrian Hayday and Frank Nestle.

‘For transplantation therapy to achieve greater success, advance is needed in several directions,’ says the Centre’s Director, Professor Sacks. ‘We need to find alternative sources of donor tissues and cells that lend themselves to therapy for a larger number of conditions, such as kidney and liver failure, arthritis, diabetes and tooth decay. Also, we need to find a way of ensuring that the replacement tissue is accepted without requiring lifelong drugs to block the immune system.’ Other key investigators collaborating in the new Centre include Professors Robert Lechler, Adrian Hayday, Reza Razavi, Ellen Solomon, Paul Sharpe, Frank Nestle, Genevra Richardson and Dr Cosimo De Bari. The translational nature of the Centre’s research will further enhance the close clinical alliance with King’s partner NHS Trusts

– King’s College Hospital NHS Foundation Trust and Guy’s and St Thomas’ NHS Foundation Trust. These Trusts run one of the largest clinical transplant programmes in Europe and the largest living kidney and liver practice in the UK.

‘Facilitate more rapid and effective solutions’ ‘By bringing together at a single Centre a wide range of expertise in basic and clinical research, we hope to facilitate more rapid and effective solutions to some of the problems associated with transplantation,’ Professor Sacks adds. ‘The Centre is the first of its kind in the UK and possibly Europe, and emphasises the continued vision of the MRC for the advancement of medical science

into clinical practice.’ The Principal, Professor Rick Trainor, comments: ‘Transplantation is an important area of biomedical research at King’s and we have a number of world-class research programmes in this field. I would like to congratulate Steven and his colleagues on their tremendous achievement in securing a new Medical Research Council Centre. We are delighted to be collaborating with the MRC on this initiative. It enhances our ongoing partnership with them and means that King’s now has five prestigious MRC Centres, all focussed on groundbreaking research aimed at improving human health.’ Professor Colin Blakemore, Chief Executive of the MRC, says: ‘With more than 6,000 patients waiting for organs in the UK and with the supply of organs dwindling, it is crucial that we strive to overcome the hurdles we face. The MRC Centre for Transplantation at King’s will use a number of different interventions in both the recipient and the donated tissue to enhance the quality of transplants and make more organs suitable for donation. The MRC is keen to support research that aims to bring together experts in different disciplines and encourages scientists in hospitals and laboratories to work together to improve healthcare as quickly as possible.’ continued on page 2


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