Comment 159 - March 2005

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COMMENT THE COLLEGE NEWSLETTER

ISSUE NO

159 |

MARCH

2005

Stem cell hope for Motor Neurone Disease

The researchers plan to generate stem cells that carry MND-causing gene defects. By turning these stem cells into motor neurones they will have a unique opportunity to discover the processes that lead to the cells’ degeneration.

ING’S RESEARCHER Professor Christopher Shaw and Dolly-the-sheep creator Professor Ian Wilmut and Dr Paul de Sousa (who are both from the Roslin Institute) announced last month that they have been granted a licence by the Human Fertilisation and Embryology Authority (HFEA)

Only the second licence ever granted by the HFEA

K

to generate stem cell lines using Cell Nuclear Replacement. The cells will be used to study Motor Neurone Disease (MND). ‘This is potentially a big step forward for MND research,’ explains Christopher Shaw, Professor of Neurology and Neurogenetics at the Institute of Psychiatry. ‘We have spent

20 years looking for genes that cause the disease and to date we have come up with just one gene. We believe that using Cell Nuclear Replacement will greatly advance our understanding of why motor neurones degenerate in this disease, without having to first hunt down the gene defect.’

GREG FUNNELL

The cultured neurones will also be used to discover drugs that can stop or reverse the disease process. Hundreds of thousands of drugs can be quickly screened in cultured cells within a year for around £100,000, whereas, it takes nearly two years and £20 million to screen just one drug in patients. This technique could dramatically accelerate the discovery of new drugs that can effectively block the disease process. ‘This is only the second licence ever granted by the HFEA to use this technique, often referred to as therapeutic cloning. Our aim will be to generate stem cells purely for research purposes,’ says Professor Wilmut. ‘We are delighted with the HFEA decision. Now that the licence has been granted the next task is to raise enough money to carry out this research, which is easier said than done,’ continues Professor Shaw. Continued on page 2

Tsunami event: Rameet Singh Uberio and Arjun Singh Kaint from the Sikh Society perform a dhol and tabla duo at the fundrasing event for the Tusanmi disaster in Tutu’s. The proceedings were opened with an extract from Meditations XV by John Donne read by Professor Phil Whitfield, Vice-Principal (Students), who was standing in for the Principal. This was followed by three student eye witness accounts of the tragic events in South East Asia. They were given by Bala Karunakaran, third year medic, Naresh Verlander, first year computer science student and an anoymous one read by Michael Champion, KCLSU president. The event was rounded off by Jazz4Peace. The amount raised by the College was more than £2,000.

2 Commemoration Oration | 3 Ministerial event Hefce grant | 4 Graduation ceremonies | 6 New Masters | 7 Volunteering award | 8 Profile: Alison Wolf | 9 Departmental focus | 10 King’s people | 12 Burdett Institute | 14 In the news | 15 Flashback | 16 Books


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