Cleaning-In-Place (CIP) and Sterilization-In-Place (SIP)

These cip and sip system pharma machinery supplier benefited greatly from the arrival of CIP processes Cleaning-In-Place (CIP) and Sterilization-In-Place (SIP) are systems designed for automatic cleaning and disinfecting without major disassembly and assembly work. We design, develop, manufacture, supply and install Mobile and Fixed CIP & SIP Units for sanitization and sterilization. The units are custom made, modular, skidded in automated or semi-automated Models as per the required time cycle for cleaning and sterilization as a part of cGMP requirements from portable to large fixed Multi-Tank system.

Up until the fifties, sealed systems such as pipes or process equipment in technical process plants had to be dismantled and cleaned by hand. This was invariably a time-consuming process. Especially in industrial sectors such as pharmaceuticals, food and beverage, where frequent and regular cleaning was required, manual cleaning of a system consumed an enormous amount of time.

CIP – Clean-In-Place These cip and sip system pharma machinery supplier benefited greatly from the arrival of CIP processes. This is because a cleaning method had been created that is still in use today, one which enables the internal surfaces of sealed systems to be cleaned without the need for disassembly (or only to a limited extent). For the most part, the CIP process is an entirely automatic one, to comply with defined process times and parameters. The cleaning operation is performed in a series of defined steps, as this flow diagram illustrates. Depending on the application, cleaning temperatures are up to 100 °C. A turbulent flow is also required, with flow rates usually between 1.5 and 3 m/s, to remove all impurities.

SIP – Sterilization-In-Place The SIP process, also referred to as ‘Steam-In-Place’, is an extension of the CIP process by an additional sterilisation, without any necessity for disassembling the plant and the measuring equipment1. The sterilisation of hygiene-critical processes takes place at the end of the actual CIP process. This ensures that any microorganisms still active in the system are killed off with hot water or with saturated pure steam at high temperatures (> 121 °C), without using an autoclave2. Of course, Percikot offers appropriate measurement technology for CIP and SIP for a comprehensive range of measurement parameters in sanitary applications.

SCOPE OF CIP UNIT: 1) CIP Tank/Tanks, Jacketed/Non-Jacketed

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Supply Pump/Return Pump Heater as required Dosing Tanks/Pumps Inter-connected Pipings / Valves / Instrumentation Automation System/Control Panel SS Skid/SS Platform

SCOPE OF SIP UNIT: 1) Pure Steam Header with PI, TI & Safety Valve 2) Condensate Header with sterile steam trap unit and Temp. Sensor 3) PLC Control Panel with Time / Temperature control program, printer, alarm etc. as required 4) SS Mobile Stand with PU Castors Benefits CIP/SIP System:

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Based on Time Action Flow Chemical Temperature cleaning cycle principles Defined module and automation Compliance to ISPE, ASME-BPE, cGMP guidelines Easy to integrate with existing process system with all the essential analytical instruments Custom designed as per process requirements Cost and reliability gains from reduced manual work and reduced risk of accidental recontamination Consistent cleaning efficiency with minimum CIP fluid requirements Ensures efficient, automatic cleaning of process lines and vessels