Frost & Sullivan Technology Innovation Award Precision Medicine

Technology Innovation Award Precision Medicine Platform Solutions GLOBAL

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Contents Background and Company Performance

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Kanteron Systems' Technology Attributes and Future Business Value

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Conclusion

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Industry Challenges

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Significance of Technology Innovation

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Understanding Technology Innovation

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Best Practices Recognition: 10 Steps to Researching, Identifying, and Recognizing Best Practices

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The Intersection between 360-Degree Research and Best Practices Awards

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Research Methodology

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About Frost & Sullivan

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Copyright

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Background and Company Performance Industry Challenges Precision medicine can drive positive outcomes for all stakeholders—patients, providers, payers, and pharmaceutical companies—through ensuring timely intervention with

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evidence-based patient services. In the United States (US) alone, agencies such as the National Institute of Health and National Cancer Institute were allocated $320 million under the Precision Medicine Initiative to consider precision medicine as a stand-alone patient care approach. However, healthcare information technology (IT) ecosystems around the world are not adequately equipped to facilitate seamless data interoperability across the care continuum—fundamental for enabling precision medicine. The consequences are often dire, particularly in the case of high-risk and costly disease sectors where timely access to relevant information is a critical prerequisite of improved patient outcomes.

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A lack of integrated services, e.g., shared electronic patient information across organizations, further leads to disparate data and subsequent variations in treatment access and quality.1 At the same time, personalized therapies that employ genomic research and next-generation sequencing technology spur vast amounts of data that are increasingly challenging to collate, store, access, analyze, and exchange.

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Frost & Sullivan notes that the ability to share data, images, and test results efficiently is crucial to speeding up diagnosis and streamlining physicians’ workflows. However, many clinicians employ both legacy and state-of-the-art computer systems to perform digital pathology scans, PET, CT, X-rays, and MRIs, resulting in systems that often do not work with another. Consequently, tests can take weeks to process or have to be repeated.

Additionally, a majority of complex clinical medications continue to be prescribed on a trial and error basis, contributing to higher costs and diminished patient outcomes.

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Solution providers who can leverage advanced informatics tools that integrate research and clinical data while digitizing and automating patient data capture, analysis, and reporting will enjoy rapid adoption. A large-scale, standardized, interoperable open source platform with professional annotation, analytics, and curation can advance biomedical informatics and reduce overall costs further.2 Frost & Sullivan notes that advanced data mining and filtering capabilities, interoperability, and ease-of-use are key competitive factors, as clinicians require intuitive platforms that can effectively sort through massive data sets while fitting into existing workflows seamlessly. Frost & Sullivan research further reveals that an efficiently deployed and managed robust patient data repository that remains electronic health record (EHR) and health information exchange platform-agnostic will provide a competitive advantage.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413698/ https://www.ncbi.nlm.nih.gov/books/NBK207309/

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Kanteron Systems’ Technology Attributes and Future Business Value Founded in 2005 and headquartered in Valencia, Spain, Kanteron Systems (Kanteron) is a pioneer in precision medicine clinical data integration and management platform solutions that advance clinical translational research processes.

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With the ability to efficiently combine medical imaging, genomics, digital pathology, and bio-sensor data, Frost & Sullivan research reveals that Kanteron’s innovative platform provides industry-leading data accuracy that enables precision medicine applications at the point of care (POC). Specifically, Kanteron’s globally recognized Translational Medical Information Server (TMIS) addresses disparate cancer-care processes—e.g., data and medical imaging sharing—by standardizing formats. As a result, pathologists and radiologists can view scans irrespective of what system they use. Furthermore, Kanteron’s robust database allows clinicians to tailor medications based on a patient’s genomic profile within seconds. As TMIS is open source, Kanteron’s platform assures interoperability and, therefore, rapid adoption. The company’s automated platform is available in multiple clouds or on premises and can interoperate with clinical enterprise systems including radiology information systems, lab information systems, and EHRs. Unlike competitors who struggle to apply algorithms on disparate patient data that are not formatted in predetermined standards, thereby restricting the ability to predict patient risk and disease outbreaks atscale, Kanteron leverages industry-leading partnerships with firms such as Google and Microsoft to provide advanced predictive analytics as well as quickly and accurately curate, integrate, and report diverse data streams.

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Kanteron leverages its prior focus on managing and distributing medical images, such as scans, to create a more comprehensive offering that incorporates components that were formerly missing, e.g., digital pathology, genomics, and bio-sensors. Kanteron’s CEO, Jorge Cortell, initiated the shift in response to the cancer diagnosis of his future wife, after witnessing firsthand the efficiencies within oncology healthcare delivery. Cortell’s expert team represents diverse disciplines including satellite and medical imaging, video game design, and robotics—spurring innovation by allowing the company to address challenges in a creative and unorthodox manner. Kanteron is deploying its advanced solution globally, and clients include the United Kingdom’s National Health Service, the American College of Radiology, Spain’s Seguridad Social, and EsSalud in Peru.

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How It Works

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Frost & Sullivan appreciates that Kanteron’s clinically-led platform links to over 160 databases that display data such as biopsies and PET scans and can synthesize data to offer superior clinical decision support. The company’s platform runs on Azure, Microsoft’s cloud-computing service, Google Cloud Platform or on premises which allows for easy collaboration between clinicians—for example, doctors can collaborate on a patient remotely—as well as enhanced security. The company also offers an optional patient portal, which hospitals’ administrators can activate at will. Finally, Kanteron can track biosensor data from devices and wearables, such as Microsoft Band, Apple Watch Series 4, or medical devices on a single screen. Frost & Sullivan firmly believes that Kanteron’s responsive, ultra-practical, and user-friendly interface alongside the platform’s ability to operate as a single solution integrated with the workflow at the POC provides a uniquely powerful value proposition.

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Future Focus

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Currently, Kanteron is partnering with Google and the University of Cambridge to develop its artificial intelligence, algorithms, and overall efficacy further. As a result, the company’s advanced filtering identifies genomics in a greatly reduced timeframe—from the industry standard of 48 to 72 hours to deliver results within minutes. Frost & Sullivan notes that Kanteron provides robust training and technology support alongside industry-leading scalability, the consequence of having re-engineered its platform twice in recent years to ensure flexibility to support upgrades. Due to its customer-centric focus, proven product, and ever-widening reference base, Frost & Sullivan independent analysis confirms that Kanteron is experiencing phenomenal growth—nearly tripling its revenues this year alone.

At present, the company has clients on four continents and an order pipeline that stands at hundreds of millions of dollars.

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Conclusion

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Despite the lifesaving potential of precision medicine, inefficient data share processes compromise cancer care globally. Kanteron Systems (Kanteron) leverages cutting-edge technology to connect and automate the integration of genomic, molecular, and clinical data efficiently—leading to enhanced care coordination and patient outcomes. The company’s comprehensive platform further standardizes scanning and diagnostic devices across disparate systems—thereby spurring industry-leading efficiencies and accuracy that can save lives. For its disruptive potential, technical excellence, and thought leadership, Kanteron earns Frost & Sullivan’s 2018 Technology Innovation Award in the global precision medicine platform solutions market.

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Significance of Technology Innovation Ultimately, growth in any organization depends upon finding new ways to excite the market and upon maintaining a long-term commitment to innovation. At its core, technology innovation, or any other type of innovation, can only be sustained with

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leadership in three key areas: understanding demand, nurturing the brand, and differentiating from the competition.

Understanding Technology Innovation Technology innovation begins with a spark of creativity that is systematically pursued, developed, and commercialized. That spark can result from a successful partnership, a productive in-house innovation group, or a bright-minded individual. Regardless of the source, the success of any new technology is ultimately determined by its innovativeness and its impact on the business as a whole. © Frost & Sullivan 2018

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Best Practices Recognition: 10 Steps to Researching, Identifying, and Recognizing Best Practices

OBJECTIVE

KEY ACTIVITIES

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Frost & Sullivan analyst follow a 10-step process to evaluate Award candidates and assess their fit with select best practice criteria. The reputation and integrity of the Awards are based on close adherence to this process.

 Conduct in-depth industry research  Identify emerging sectors  Scan multiple geographies

Pipeline of candidates who potentially meet all bestpractice criteria

Perform comprehensive, 360-degree research on all candidates in the pipeline

 Interview thought leaders and industry practitioners  Assess candidates’ fit with best-practice criteria  Rank all candidates

Matrix positioning of all candidates’ performance relative to one another

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Invite thought leadership in best practices

Perform in-depth examination of all candidates

 Confirm best-practice criteria  Examine eligibility of all candidates  Identify any information gaps

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Initiate research director review

Conduct an unbiased evaluation of all candidate profiles

 Brainstorm ranking options  Invite multiple perspectives on candidates’ performance  Update candidate profiles

Final prioritization of all eligible candidates and companion best-practice positioning paper

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Assemble panel of industry experts

Present findings to an expert panel of industry thought leaders

 Share findings  Strengthen cases for candidate eligibility  Prioritize candidates

Refined list of prioritized Award candidates

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Conduct global industry review

Build consensus on Award candidates’ eligibility

 Hold global team meeting to review all candidates  Pressure-test fit with criteria  Confirm inclusion of all eligible candidates

Final list of eligible Award candidates, representing success stories worldwide

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Perform quality check

Develop official Award consideration materials

 Perform final performance benchmarking activities  Write nominations  Perform quality review

High-quality, accurate, and creative presentation of nominees’ successes

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Reconnect with panel of industry experts

Finalize the selection of the best-practice Award recipient

 Review analysis with panel  Build consensus  Select recipient

Decision on which company performs best against all best-practice criteria

Inform Award recipient of Award recognition

 Announce Award to the CEO  Inspire the organization for continued success  Celebrate the recipient’s performance

Announcement of Award and plan for how recipient can use the Award to enhance the brand

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Perform 360-degree research

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Detailed profiles of all ranked candidates

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Monitor, target, and screen

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Identify Award recipient candidates from around the globe

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Communicate recognition

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Upon licensing, company is able to share Award news with stakeholders and customers

Take strategic action

 Coordinate media outreach  Design a marketing plan  Assess Award’s role in future strategic planning

Widespread awareness of recipient’s Award status among investors, media personnel, and employees

The Intersection between 360-Degree Research and Best Practices Awards

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Research Methodology

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Frost & Sullivan’s 360-degree research 360-DEGREE RESEARCH: SEEING ORDER IN methodology represents the analytical THE CHAOS rigor of our research process. It offers a 360-degree-view of industry challenges, trends, and issues by integrating all 7 of Frost & Sullivan's research methodologies.

Too often companies make important growth decisions based on a narrow understanding of their environment, leading to errors of both omission and commission. Successful growth strategies are founded on a thorough understanding of market, technical, economic, financial, customer, best practices, and demographic analyses. The integration of these research disciplines into the 360-degree research methodology provides an evaluation platform for benchmarking industry participants and for identifying those performing at best-in-class levels.

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About Frost & Sullivan

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Frost & Sullivan, the Growth Partnership Company, enables clients to accelerate growth and achieve best-in-class positions in growth, innovation and leadership. The company's Growth Partnership Service provides the CEO and the CEO's Growth Team with disciplined research and best practice models to drive the generation, evaluation and implementation of powerful growth strategies. Frost & Sullivan leverages more than 50 years of experience in partnering with Global 1000 companies, emerging businesses, and the investment community from 45 offices on six continents. To join our Growth Partnership, please visit http://www.frost.com.

Copyright This research is owned by Frost & Sullivan. No part of this research may be disclosed to external parties without formal written permission from Frost & Sullivan. Furthermore, no © Frost & Sullivan 2018

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part may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the written permission of Frost & Sullivan.

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