Comprehensive Drug Metabolism and Pharmacokinetics (DMPK)
Services by Jubilant
In the modern pharmaceutical industry, understanding how a drug behaves inside the body is crucial for its success. Drug Metabolism and Pharmacokinetics (DMPK) plays a vital role in determining the safety, efficacy, and dosing of a potential therapeutic candidate. At Jubilant Biosys, we offer integrated DMPK services to support pharmaceutical, biotechnology, and academic clients in optimizing drug candidates and accelerating their path to clinical trials.
With cutting-edge infrastructure, highly skilled scientists, and regulatory-compliant practices, Jubilant Biosys provides end-to-end ADME (Absorption, Distribution, Metabolism, and Excretion) and pharmacokinetic solutions to ensure informed decision-making at every stage of the drug discovery and development process.
Understanding DMPK in Drug Development
DMPK studies are designed to evaluate:
• Absorption – How a drug enters the bloodstream after administration.
• Distribution – How the drug spreads through body tissues and fluids.
• Metabolism – How the body breaks down the drug into active or inactive metabolites.
• Excretion – How the drug and its metabolites are eliminated.
By analyzing these processes, researchers can determine the optimal dose, formulation, and route of administration. This helps in predicting drug efficacy, safety, and potential side effects.
Jubilant Biosys – Your Trusted Partner for DMPK Services
At Jubilant Biosys, our DMPK department works closely with medicinal chemists, biologists, and toxicologists to provide integrated solutions that accelerate the drug discovery pipeline. We offer both in vitro and in vivo DMPK studies tailored to client-specific requirements.
1. In Vitro ADME Services
Our in vitro studies provide critical data on drug behavior at an early stage, helping to predict in vivo performance and avoid costly late-stage failures. Our capabilities include:
• Metabolic stability assays (liver microsomes, hepatocytes)
• Cytochrome P450 inhibition and induction studies
• Plasma protein binding
• Permeability assays (Caco-2, MDCK)
• Solubility studies
• Transporter studies (uptake and efflux)
2. In Vivo Pharmacokinetics
We conduct preclinical pharmacokinetic studies in various animal models to determine drug exposure, half-life, clearance, and bioavailability. Our expertise includes:
• Single and multiple dose PK studies
• Bioavailability and bioequivalence studies
• Dose proportionality
• Tissue distribution studies
• Metabolite profiling
3. Bioanalytical Services
Our GLP-compliantbioanalytical laboratories support DMPK studies with precise and accurate quantification of drugs and metabolites using:
• LC-MS/MS
• HPLC
• GC-MS
• Validated analytical methods
4. Metabolite Identification and Profiling
We identify and characterize primary and secondary metabolites to assess their pharmacological or toxicological relevance. Our metabolite profiling helps in regulatory submissions and safety evaluations.
5. Drug-Drug Interaction (DDI) Studies
Understanding the potential for drug-drug interactions is critical for clinical safety. We evaluate enzyme inhibition, induction, and transporter-mediated interactions to minimize risks.
Therapeutic Areas Served
Jubilant Biosys has extensive experience providing DMPK support for drug discovery programs in:
• Oncology – Novel cancer therapies targeting tumor growth and metastasis.
• Central Nervous System (CNS) Disorders – Treatments for Alzheimer’s, Parkinson’s, depression, and epilepsy.
• Pain and Inflammation – Innovative solutions for pain and inflammatory diseases.
• Metabolic Disorders – Drugs for diabetes, obesity, and cardiovascular health.
Why Choose Jubilant Biosys for DMPK Services?
1. End-to-End Integration – Our DMPK team collaborates seamlessly with chemistry, biology, and toxicology groups.
2. Cutting-Edge Technology – Advanced LC-MS/MS platforms, automated sample preparation, and high-throughput screening capabilities.
3. Regulatory Compliance – GLP-compliant labs adhering to FDA, EMA, and ICH guidelines.
4. Customized Solutions – Flexible study designs to meet specific project needs.
5. Global Client Base – Trusted by pharmaceutical and biotech companies worldwide.
Accelerating Decision-Making in Drug Discovery
Early and accurate DMPK profiling enables better compound selection, reduces attrition rates, and shortens development timelines. By partnering with Jubilant Biosys, clients gain access to:
• Rapid turnaround times
• Expert scientific interpretation
• Cost-effective and scalable services
• Data packages suitable for regulatory submissions