Evaluation of spherical agglomerated crystals of Lomefloxacin by IR and optical microscopy

Page 1

Journal of Research in Biology

ISSN No: Print: 2231 –6280; Online: 2231- 6299

An International Scientific Research Journal

Original Research

Journal of Research in Biology

Evaluation of spherical agglomerated crystals of Lomefloxacin by IR and optical microscopy Authors:

ABSTRACT:

Institution: 1. Associate Professor, Department of Pharmaceutical Biotechnology, Chilkur Balaji College of Pharmacy, Hyderabad.

The spherical crystallization technique was studied to improve the dissolution rate and bioavailability of lomefloxacin which is used as an antibacterial agent for Typhoid, Vaginal, GIT and ENT infection. In solvent change method, irregular shaped agglomeration was observed. Neutralization method was performed to maintain the form of spherical crystals. In ammonia diffusion method, best form of spherical agglomerates with crystal form was obtained. Spherical agglomerated crystals of lomefloxacin were evaluated by IR and optical microscopy. The results suggested that the spherical crystal form of lomefloxacin shows greater dissolution rates and bio availability.

Muthukumar N1 and Harry Thomas Rodriguez A2

2. Antarcticaa College of Pharmacy, Tamil Nadu India. Corresponding author:

Keywords: Spherical crystallization, Lomefloxacin, IR and Optical microscopy

Muthukumar N

Web Address: http://jresearchbiology.com/ documents/RA0463.pdf

Article Citation: Muthukumar N and Harry Thomas Rodriguez A Evaluation of spherical agglomerated crystals of Lomefloaxacin by IR and optical microscopy. Journal of Research in Biology (2014) 4(8):1405-1416 Dates: Received: 12 Jul 2014

Accepted: 27 Jul 2014

Published: 13 Aug 2014

This article is governed by the Creative Commons Attribution License (http://creativecommons.org/ licenses/by/4.0), which gives permission for unrestricted use, non-commercial, distribution and reproduction in all medium, provided the original work is properly cited. Journal of Research in Biology An International Scientific Research Journal

1405-1416| JRB | 2014 | Vol 4 | No 5

www.jresearchbiology.com


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