NTP Radioisotopes SOC Ltd (Mapula Letsoalo)

NTP Radioisotopes SOC Ltd A subsidiary of Necsa Ltd Pelindaba, South Africa

NTP’S ROLE IN NUCLEAR MEDICINE GLOBALLY AND COOPERATION WITH BELGIUM

Mapula Letsoalo 2013 October 23

www.ntp.co.za

Depleted Uranium Fabrication Facility (Pelindaba) Contents

• Role in global Mo-99 supply • Role in SA nuclear medicine • Continued relations with IRE

Geographical GeographicalLocation LocationofofNTP NTPRadioisotopes Radioisotopes Pretoria

NTP located at the Necsa Pelindaba Site

OR Tambo Soweto

Johannesburg

The Real And Lasting Victories Are Those Of Peace In 1991, the South African government signed the

Non-Proliferation Treaty (NPT) and became the first and only nation to voluntarily declare and

dismantle its nuclear weapons

And they shall beat their swords into ploughshares ... – Isaiah 2:4

Mo-99 Production & Related Facilities

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Radiochemical Production Plant Commercial Office Radiopharmaceutical Production Plant Radioanalytical Labs SAFARI-1

SAFARI-1 Reactor Nuclear Reactor

Mo-99 Production at NTP Enriched Uranium Inventory

Fuel Production Plant

Nuclear Fuel Assemblies

SAFARI-1 Reactor Target Plate Irradiation

Target Plates

Irradiated plates

Depleted Uranium Inventory

Waste

Nuclear Waste Management

Radiochemical Production Plant Chemical Extraction and purification of Mo-99 Waste Disposal & Storage Facilities

Transport Container Design Manufacture, License NTP Generator Manufacture

International Market

Local & International Users

NTP -Product Portfolio IRE Cooperation •

Collaborative partnership since 1997

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Mo-99 Supply crisis

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Increased production output Mo-99 Supply - Crisis Conditions ARI 5%

NTP 40%

IRE 30%

Covidien 25%

Total: 8 000 Ci/week

RadioisotopeSource Source Containers Containers Radioisotope Depleted uranium fabrication facility

Radiochemical Transport Containers (1 500 Ci Mo-99, 125kg)

Subsidiary Subsidiary Companies Company

ďƒź NTP Logistics is a joint venture company between NTP Radioisotopes (51 %) and a BEE partner ďƒź Specialize in managing the logistics of dangerous goods including radioactive materials.

NTP ProductofPortfolio Conversion Mo-99 Production to LEU

2011 •Routine supply of LEU Mo-99 (June)

2010 2009 2008 •Cold and depleted uranium experiments

2007 •Theoretical feasibility studies

•NNR approval received for test stage •Hot runs commence

•Submission to Regulators (June) •Validation runs (July) •NNR approval routiine ops (Sept) •FDA approval for use in US (Nov)

Medicals Facilities Medical Facility 3

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Medicals & Industrials SAFARI-1 Cyclotron facility

Nuclear Medical Isotopes & Related Products Radiopharmaceuticals Radiopharmaceuticals NovaTec-P Tc-99m Generator, Cold kits F-18 FDG I-131 Capsules, Solution and MIBG

New Lu-177 dotatate

F-Choline

Subsidiary Companies Company

ďƒź NTP has a 100% shareholding in AEC-

Amersham SOC Ltd ďƒź Exclusive distributor in Africa of NTP's radiopharmaceutical products as well as

a range of life science research and other products.

Corporate Social Investment  PET/CT Scanner donated to people of Western Cape  Located at Tygerberg PET/CT Centre  Official opening - April 2012

Subsidiary SubsidiaryCompanies Company

 Fully-owned subsidiary company NTP Radioisotopes (Europe) S.A.

 Established on 1 February 2013  Located in Belgium – IRE site  Manufacturer and distributor of gamma-radiography equipment used in the non-

destructive testing (NDT) industry, including sealed radioactive sources containing Ir192, Se-75 and Co-60, as well as the GammaMat range of NDT projectors and accessories

 Also manufactures a range of Ir-192 brachytherapy products

Subsidiary ConclusionCompanies Necsa/ NTP’s nuclear technology is making a major contribution to the economy

and to our country’s global standing.

Subsidiary Companies Thank you very much!