Top 4 Anti Fungal Medicines For Candidness In The Vagina & Throat
The top 4 antifungal medicines for candidiasis or fungal infections in the throat and vagina are Fluconazole, Clotrimazole, Miconazole, and Nystatin. Do you know 75% of all women in the world suffer from vulvovaginal candidiasis? It may get fatal as a bloodstream infection if left untreated. These medicines manage and treat the overgrowth of candida species of fungus in patients. Furthermore, Fluconazole API or Active Pharmaceutical Ingredients along with other antifungals of the azole family are used to make both oral and suspension doses. Let’s know more about candidiasis, the mechanism of action of the antifungal medicines, dosage, side effects, availability and other details.
Mechanism of action of anti-fungal medicines on Candidiasis The main mechanism of action of antifungal medicines is to cease the growth of yeast or fungus by inhibiting their further cell synthesis. These medicines inhibit the enzyme lanosterol 14α demethylase, which is dependent on cytochrome P450. The main function of this enzyme is to support fungal cell synthesis by conversion of lanosterol to ergosterol. Fluconazole has a free nitrogen atom that attaches with a single iron atom on the heme group of lanosterol 14α demethylase. This process inhibits ergosterol biosynthesis, arrests further fungal growth, and destroys the plasma cell membrane of fungi.