Volume 32
Issue 2, 2013
ISSX President’s Message: Fulfilling the ISSX International Mission Today and in the Future By Bill J. Smith, ISSX President One aspect that sets ISSX apart from other similar organizations appears pronouncedly in our mission statement: “ISSX is an international association of scientists that promotes the understanding of the interactions of medicines and chemicals with living systems.” As an international association, we strive to meet the needs of many regions and countries interested in advancing the broad sciences under the umbrella of ISSX. North America and Europe have historically been core to ISSX and even today make up the majority of our membership base. However, to continue to serve the needs of our members, we need to sustain and grow membership and especially increases attendance at our meetings. One strategy to achieve this is to expand into regions of the world where the science is growing so that we may attract new members and meeting attendees in order to advance our mission. Two
examples that describe activities that support this strategy follow. India is a nation where the science of drug metabolism and pharmacokinetics is growing within universities, pharma/biotech, instrument vendors, and contract research organizations. ISSX has a few members in India but to date has not organized a meeting or workshop in this country. I attended meetings in Hyderabad and Chandigarh in March in part to gain knowledge regarding how ISSX could help. I was truly struck by the energy and enthusiasm of the students, faculty, and industry scientists. In return, they were excited by the interest shown by ISSX. I attended a conference organized by Applied Pharmaceutical Analysis which has organized conferences in India for about five years. This group has strengths that are complementary to ISSX and represents a potential future collaborator. The ISSX Council
is currently considering what we learned and is discussing how we may increase our activity in India. My next example comes from Kaifeng, Henan, China where ISSX speakers supported a student workshop organized jointly by the Chinese Society for the Study of Xenobiotics (CSSX) and ISSX. This was the fifth CSSX/ISSX collaboration in China. Approximately 80 students gave oral presentations in English with about 250 attendees. ISSX bestowed Professors Honghao Zhou (Central South University, Changsha, Henan, China) and Changxiao Liu (Tianjin Institute for Pharmaceutical Research, Tianjin, China), with awards to recognize and celebrate their commitment to the educational development Continued on page 10
IN THIS ISSUE 1
ISSX President’s Message
2 Upcoming Meetings
4 New Members
2
Book Review: Flavonoids and Related Compounds
3
10th International ISSX 5 Special Meeting Announcement
ISSX/NEDMDG Workshop on The Role of Drug Metabolism in Immune-Mediated Drug Toxicity
Book Review FLAVONOIDS AND RELATED COMPOUNDS
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Bioavailability and Function Editors: Jeremy PE Spencer and Alan Crozier CRC Press, Taylor and Francis Group, Florida, US. 451pp, ISBN 978-1-43984826-5, 2012 Apparently, around one-fiftieth of all of the carbon fixed by photosynthesisassociated reactions within the plant kingdom (roughly 1x109 tonnes/year) is utilized for the production of flavonoids or closely related substances and they are, therefore, one of the largest groups of naturally occurring plant phenols. The flavonoids are associated commonly with sugar residues as this combination tends to render the flavonoid less reactive and more resistant to enzymatic degradation, makes it less susceptible to photodecomposition and enhances its water (sap) solubility. Many thousands of naturally occurring flavonoids now have been characterized fully and this information has enabled the different types of flavonoids to be grouped according to similarities and subtleties in their detailed chemical structure. One such classification comprises the following groups (chalcones, flavan-3-ols [catechins], flavanones, flavanols, flavones, anthocyanins, isoflavonoids, neoflavonoids), but where the precise boundaries for flavonoid inclusion (e.g. proanthocyanidins?) exists is a continuing matter of academic debate.
It is against this background that the two editors have sought to compile a compendium that brings to the fore up-to-date information concerning these dietary components. Forty seven contributors have constructed 19 chapters, the titles of which are as follows: “Bioavailability of flavanones,” “Bioavailability of dietary monomeric and polymeric flavan3-ols,” “Anthocyanins: Understanding their absorption and metabolism,” “Bioavailability of flavonols and flavones,” “Bioavailability of isoflavones in humans,” “Dietary hydroxycinnamates and their bioavailability,” “Bioavailability of dihydrochalcones,” “Occurrence, bioavailability, and metabolism of resveratrol,” “Bioavailability and metabolism of ellagic acid and ellagitannins,” “Colon-derived microbial metabolites of dietary phenolic compounds,” “Synthesis of dietary phenolic metabolites and isotopically labeled dietary phenolics,” “Interactions of flavan3-ols within cellular signaling pathways,” “Flavonoids and vascular function,” “Effects of flavonoids on the vascular endothelium: What is known and what is next?,” “Green tea flavan-3-ols and their role in protecting against Alzheimer’s and Parkinson’s disease pathophysiology,” “Flavonoids and neuroinflammation,” “Effects of flavonoids on cognitive performance,” “Flavonoids and oral cancer,” and “Flavonoids and cancer – effects on DNA damage.” The preface informs us that the bioactivity of these compounds was
thought to be, “attributed to their ability to exert antioxidant actions” but now evidence has suggested that it is, “highly unlikely that this classical hydrogen-donating antioxidant activity accounts for the bioactivity of these compounds,” and that, “cellular effects are mediated by interactions with specific proteins central to intracellular signaling cascades” (page xiii). Roughly half of the chapters focus on the bioavailability of these compounds and their metabolic conversions within the gut lumen before absorption. The latter chapters draw attention to their beneficial effects against various human pathological conditions and offer insights into potential mechanisms of action. As stated by the editors, the aim of the book is to provide, “an overview for anyone interested in the bioavailability and biological function of a range of flavonoids relevant to a wide array of plant-based foods” (page xiii) and I, for one, would agree that the book has achieved this aim.
Reviewed by
Steve Mitchell Faculty of Medicine Imperial College London London SW7 2AZ, UK
Book ordering information:
CRC Press Taylor and Francis Group 6000 Broken Sound Parkway NW, Suite 300, Boca Raton, Florida FL 33487-2742 http://www.taylorandfrancis.com http://www.crcpress.com
UPCOMING MEETINGS 10th International ISSX Meeting
5th Asia Pacific Regional ISSX Meeting
29th JSSX and 19th North American Regional ISSX Meeting
20th North American Regional ISSX Meeting
The Westin Harbour Castle Hotel Toronto, Ontario, Canada September 29–October 3, 2013
Crowne Plaza Tianjin Binhai Hotel Tianjin, China May 9–12, 2014
Hilton San Francisco San Francisco, California, USA October 19–23, 2014
Hilton Orlando Bonnet Creek Orlando, Florida, USA October 17–21, 2015
ISSX/NEDMDG Workshop on The Role of Drug Metabolism in Immune-Mediated Drug Toxicity The joint Workshop organized by ISSX and the New England Drug Metabolism Discussion Group (NEDMDG) entitled The Role of Drug Metabolism in Immune-Mediated Drug Toxicity was held at the Boston Marriott Cambridge hotel in Cambridge, Massachusetts April 17–19, 2013. This workshop, chaired by Charles Crespi from Corning Life Sciences, brought together over 190 participants, exhibitors, and speakers. Over half of the total registrants attended the PreWorkshop Session which provided an overview of reactive metabolite formation and introductions to adaptive and innate immunity. The Workshop was organized around four putative mechanisms in immune-mediated drug toxicity: bioactivation, adaptive immunity, cell signaling / cell responses and innate immunity. 18 abstracts were accepted and their posters were available for view for the entirety of the workshop. The organizers needed to make some quick decisions due to the Boston Marathon bombing, which occurred on Monday, April 15, and the subsequent quarantine of a portion of the City of Boston as a crime scene. As travel to Cambridge was unaffected, the workshop proceeded. The last day of the workshop, Friday, April 19, was impacted by police activities. The residence of the accused perpetrators, the Thursday night killing of the MIT policeman, and subsequent carjacking were near the workshop venue. The City of Cambridge was in lock down for most of Friday. As over 80 of the participants and nearly all of the Friday speakers were staying in the hotel, the Workshop Organizing Committee determined it would be best to proceed with the Friday program. Many locally based attendees were also able to drive into Cambridge for the last day of the program and all transportation restrictions were lifted by the end of the day. Provisions have been made to provide the presentation materials to those attendees who were unable to attend on Friday.
Workshop Organizing Committee Charles Crespi, Corning Life Sciences, Tewksbury, MA, USA Thomas Baillie, University of Washington, Seattle, WA, USA Radford Decker, Sunovion Pharmaceuticals, Marlborough, MA, USA Robert Roth, Michigan State University, East Lansing, MI, USA Steve R. Tannenbaum, Massachusetts Institute of Technology, Cambridge, MA, USA Jack Uetrecht, University of Toronto, Toronto, Ontario, Canada Nancy Wong, Eisai Incorporated, Andover, MA, USA Zhiyang Zhao, Amgen, Cambridge, MA, USA
ISSX CAREER CENTER • www.issx.org/careercenter Submit a job posting to the ISSX Career Center before August 31 and receive a free job posting to be featured on our website and in-person at the 10th International ISSX Meeting. Please email information@issx.org for more information.
/ISSX Newsletter / 3
Workshop Speaker and Poster Presentation Abstracts are available at www.issx.org/abstractdatabase.
Issue 2, 2013
ISSX appreciates the commitment and efforts of the Workshop Organizing Committee, NEDMDG, ISSX staff, speakers, and attendees which made this endeavor a success. The quality of the science and the extraordinary local events made this a workshop which will be long remembered.
Attendees and exhibitors review posters and enjoy a refreshment break at the ISSX/NEDMDG Workshop in Cambridge, MA.
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ISSX Welcomes New 2013 Members! Sanna-Mari Aatsinki, University of Oulu, Finland Aina Adeogun, University of Ibadan, Nigeria Ingolfur Agustsson, Empiriko Corporation, United States Li Young Ahn Akinleye Akinrinde, University of Ibadan, Nigeria Yun Alelyunas, Waters, United States Kathryn Ang, Acorda Therapeutics, Inc., United States Aneesh Argikar, Temple University, United States Ann Aurell Holmberg, Astrazeneca, Sweden Lindsay Avery, Johns Hopkins University School of Medicine, United States Ramesh Bambal, Daiichi San, India Kurt Benkestock, Medivir Ab, Sweden Sukanta Bhattacharya, United States Christoffer Bundgaard, H. Lundbeck A/S, Denmark Chun Yip Chan, Department of Pharmacy Faculty of Science National University of Singapore, Singapore Nuy Chau, Flinders University School of Medicine, Australia Sylvia Chen, Laval University, Canada Jong Min Choi, Kist, Korea Daniela Cihalova, Charles University In Prague, Faculty of Pharmacy, Czech Republic Kristin Connors Philip Cox Stefano Crosignani, Iteos Therapeutics Sa, Belgium Stacey Cross, Pharma Iq, United Kingdom Cathy Cummings-Lorbetskie, Health Canada, Canada María del Carmen Martinez Guzmán, Mexico Yuzhong Deng, Genentech, United States Ryan A. Dick, Myokardia, United States Quentin Dutertre, Philip Morris International R&D, Switzerland Joan Eilstein Lisa Elkin, Bristol-Myers Squibb, United States Osama Elshenawy, UOFA Ahmed El-Sherbeni, University of Alberta, Canada Nigel Ewing, Vertex Pharamaceuticals Inc, United States Guorong Fan Huirong Fan, Tianjin Institute of Pharmaceutical Research, China Alegre Flores, Cinvestav, Mexico Kelly Frazier, Agel.Com, United States Adarsh Gandhi, United States Vaishnavi Ganti, Temple University, United States Chunying Gao Alejandro Garcia, Cinvestav, Mexico Sabine Gerbal-Chaloin, Inserm Brad Gien, Basi, United States Ravi Gilibili, University of British Columbia, Canada Raul Gonzalez, Universidad Autónoma de San Luis Potosí, Mexico Emmanuel González Leanne Grafmuller, Forest Laboratories, United States Mark Grillo, Amgen, United States Hilary Groom, University of Guelph, Canada Jingkai Gu, Jilin University, China Franãçois Guillou, Astrazeneca, Sweden
Mia Halme, Verifin / University of Helsinki, Finland Mari Hashimoto, Chiba University, Japan Pavlina Haskova Hisamitsu Hayashi, Univ. of Tokyo, Japan Bent Hellum, Ntnu, Norway Jennifer Hennen, University of Trier, Germany Brenda Hernandez, Idenix Pharmaceuticals, United States Elisabeth Hersman, Johns Hopkins, United States Stewart Hunt, Insphero, Ag, United States Oju Ibor, University of Ibadan, Nigeria Nobutomo Ikarashi, Hoshi University, Japan Peter Illes Katsuaki Ito, Teijin Pharma Limited, Japan Chatsiri Jesadakultavee, Faculty of Pharmacy, Mahidol University, Thailand, Thailand Unho Jin, Texas A&M Hsc, United States Philip Josephy, University of Guelph, Canada John Kalvass, Abbvie, Inc., United States Tatsuyuki Kanamori, National Research Institute of Police Science, Japan Yoshihiro Kawabata, Zeria Pharmaceutical Co., Ltd., Japan Hyun-Uk Kim, Mfds, Korea Jae-Eun Kim Klaus Klarskov Arno Knorr, Philip Morris International R&D, Switzerland Shinji Kobuchi, Kyoto Pharmaceutical University, Japan Anil Kolur, Eli Lilly & Company, United States Porntipa Korprasertthaworn, Flinders University School of Medicine, Australia Ayokulehin Kosoko, University of Ibadan, Nigeria Stan Kubow, McGill University, Canada Ashutosh Kulkarni, Celgene Corporation, United States Sanjeev Kumar, Vertex Pharmaceuticals, United States Julie Lade, Johns Hopkins University School of Medicine, United States Julie Laterreur, Vertex Canada, Canada Yau Yi Lau, Abbvie, Inc., United States Jean-Francois Levesque, Vertex Pharmaceuticals, Canada Yibai Li, Australia Na Li Sha Liao, Beijing Institute of Pharmacology and Toxicology, China Jinrong Liu, Abbvie, Inc., United States Jia Liu, Shanghai Institute of Materia Medica, China Alexandra Lobach, University of Toronto, Canada Van Ly, Bristol-Myers Squibb Co., United States Vanessa Martins, Astex Pharmaceuticals, United Kingdom Abdullah Al Maruf, University of Toronto, Canada Satomi Matsui, Dainippon Sumitomo Pharma Co., Ltd., Japan Jun Matsumoto, Japan Dermot Mcginnity, Astrazeneca R&D, Sweden Dawn Merritt, Zoetis, United States Kathleen Mosure, Bristol-Myers Squibb, United States Yukiko Murata, Kanazawa University, Japan
Continued on page 10
International
September 29 - October 3, 2013 Toronto, Ontario, Canada
INVITATION TO ATTEND Dear Colleagues, On behalf of the Meeting Organizing Committee, it is my great pleasure to invite you to the premier international meeting on xenobiotics: the 10th International ISSX Meeting, to convene September 29 – October 3, 2013 in Toronto, Ontario, Canada. This meeting provides a wonderful opportunity for members of the international scientific community to exchange ideas and expertise, to develop a common vision, and to create and nurture fruitful collaborations in fields related to the study of chemicals that are foreign to the body. Enjoy state-of-the-art scientific sessions, poster presentations, and commercial exhibits in a relaxed and friendly environment. Proposed topics for a combination of a keynote lecture, plenary sessions, parallel sessions and short course workshops in Toronto include: systems pharmacology and xenobiotic-host interactions; drug-metabolizing enzymes as potential therapeutic targets; metabolism and pharmacokinetics of traditional medicines; regulatory challenges in drug development and approval; toxicogenomic profiling; in vitro and cell-based systems for predicting human drug metabolism; cell type specific mechanisms of toxicity and adverse drug reactions; nuclear receptors as regulators of drug metabolism and therapeutic targets; novel biomarkers for xenobiotic-induced toxicity; utility of structural biology in predicting drug response, metabolism and ADRs; and many more. Please take this unique opportunity to expand and share your knowledge on the interaction of foreign chemicals with living systems, renew or develop friendships with your colleagues from around the world, and enjoy everything the wonderful city of Toronto has to offer. I look forward to seeing you in Toronto! Sincerely,
Denis M. Grant University of Toronto Chair, Meeting Organizing Committee
International
PROGRAM AT
SUNDAY
Promega Corporation Industry-Supported Symposium
Morning Course Attendee Continental Breakfast SHORT COURSE II
Metabolomic Profiling as a Tool for Identifying Novel Drug-Target Reactions
Model Systems and Methods for Assessing Uptake and Efflux of Small Molecules
Afternoon Course Attendee Lunch SHORT COURSE III
SHORT COURSE IV
Strategies and Techniques for Predicting Human Drug Metabolism and Drug-Drug Interactions
Application of Novel Mass Spectrometric Methods to Drug Metabolism and Pharmacokinetics Studies
OPENING WELCOME RECEPTION WITH EXHIBITORS
Thermo Scientific Industry-Supported Symposium
Bruker Dalto Industry-Supp Symposium
PLE
PLENARY SESSION 1 Drug-Metabolizing Enzymes as Potential Therapeutic Targets
Utility of Genetic Developmen
Refreshment Break, Visit Exhibitors, View Posters
Refreshment Br
ISSX AWARDS SESSION
PARALLEL SES
R.T. Williams Distinguished Scientific Achievement Award and the Frederick J. Di Carlo Distinguished Service Award
Lunch (on own), Visit Exhibitors, View Posters PARALLEL SESSION 1 PARALLEL SESSION 2 Nuclear Receptors as Regulators of Drug Metabolism and as Therapeutic Targets
Pharmacogenomics and Personalized Medicine: Progress in Clinical Implementation
Refreshment Break, Visit Exhibitors, View Posters
PARALLEL SESSION 3 PARALLEL SESSION 4 Regulation of Drug Transporter Expression and Function
Opening Welcome Address KEYNOTE LECTURE: Systems Pharmacology and Drug-Host Interactions
TU
Application of Structural Biology to the Prediction of Drug Response, Metabolism and Toxicity
YOUNG INVESTIGATORS RECEPTION
REGISTRATION OPEN
SHORT COURSE I
REGISTRATION OPEN
REGISTRATION OPEN
7:30 7:45 8:00 8:15 8:30 8:45 9:00 9:15 9:30 9:45 10:00 10:15 10:30 10:45 11:00 11:15 11:30 11:45 12:00 12:15 12:30 12:45 13:00 13:15 13:30 13:45 14:00 14:15 14:30 14:45 15:00 15:15 15:30 15:45 16:00 16:15 16:30 16:45 17:00 17:15 17:30 17:45 18:00 18:15 18:30 18:45 19:00 19:15 19:30 19:45 20:00 20:15 20:30 20:45 21:00 21:15 21:30 21:45 22:00
MONDAY
Metabolism, Pharma and Interactio Traditional Medic Natural Prod
Lunch (o
FREE AF
A GLANCE
onics ported m
WEDNESDAY
Corning Incorporated Industry-Supported Symposium
Hepregen Corporation Industry-Supported Symposium
ENARY SESSION 2
Celsis In Vitro Technologies IndustrySupported Symposium
PLENARY SESSION 3 Identification and Use of Novel Biomarkers for Xenobiotic-Induced Toxicity
reak, Visit Exhibitors, View Posters
Refreshment Break, Visit Exhibitors, View Posters
SSION 5 PARALLEL SESSION 6
PARALLEL SESSION 7 PARALLEL SESSION 8
Cell Type Specific Mechanisms of Adverse Drug Reactions
on own), Visit Exhibitors, View Posters
FTERNOON IN TORONTO
REGISTRATION OPEN
c and Epigenetic Technologies in Drug nt and Safety Assessment Targets
macokinetics ons of cines and ducts
Targeted Drug Delivery for Enhanced Therapy
THURSDAY
Use of PB-PK Modeling in Pharmaceutical Safety Assessment
REGISTRATION OPEN
UESDAY
September 29 - October 3, 2013 Toronto, Ontario, Canada
PLENARY SESSION 4 Genetically Modified Animal Models for Predicting Human Drug Disposition and Response Poster Awards Presentation Refreshment Break
PARALLEL SESSION 11 PARALLEL SESSION 12 Tissue Imaging and Distribution Studies in Drug Development
Development and Uses of Hepatocyte-Derived and Hepatocyte-Like Cells for Predicting Human Drug Metabolism
Meeting Closing Remarks
Lunch (on own), Visit Exhibitors, View Posters PARALLEL SESSION 9
PARALLEL SESSION 10
Regulatory Perspectives Toxicogenomic and Metabolomic in Drug-Drug Interactions Profiling: Current Status and Future Utility in Assessing Drug and Metabolites in Efficacy and Safety Assessment Safety Testing Refreshment Break, Visit Exhibitors, View Posters
ISSX PARTY AT THE HOCKEY HALL OF FAME (TICKETED EVENT) Program subject to change.
International
GENERAL INFORMATION
IMPORTANT DATES
Exhibitors:
Attendees:
• Exhibit Space Cancellation Deadline: Friday, June 28, 2013 Email: meetings@issx.org
• Early Registration Deadline: Friday, June 28, 2013 www.issx.org/international2013/registration • ISSX Awards Nomination Deadline: Sunday, June 30, 2013 www.issx.org/awards/nominations • Second Call for Abstracts Deadline: Friday, July 5, 2013 www.issx.org/international2013/abstracts • Hotel Reservation Deadline: Friday, August 30, 2013 www.issx.org/international2013/accommodations • Attendee Registration Cancellation Deadline: Friday, August 30, 2013 Email: information@issx.org • Last Day to Pre-Register: Friday, September 27, 2013 www.issx.org/international2013/registration
• Exhibitor Descriptions and Logos Due: Wednesday, July 31, 2013 Email: meetings@issx.org • Exhibitor Sponsorships and Advertising Placement Deadline: Wednesday, July 31, 2013 www.issx.org/international2013/exhibits • Industry Sponsored Symposia Application Deadline: Tuesday, August 13, 2013 www.issx.org/international2013/iss • Exhibit Staff Registration Deadline: Friday, September 13, 2013 Email: information@issx.org
To review the full exhibit and sponsorship opportunities, please visit
www.issx.org/international2013/exhibits.
SPECIAL EVENT ISSX Party at The Hockey Hall Of Fame Enjoy a delicious buffet, catch up with friends, and meet new acquaintances at the Hockey Hall of Fame! Located in an architecturally ornate former bank building in downtown Toronto, the Hockey Hall of Fame is only four blocks from the Westin Harbour Castle. This spectacular museum is a highly unique venue that presents Canada’s national sport through the world’s largest collection of hockey artifacts and the fun of interactive games. Attendees can take shots at real-time goalies, stop the shots of Gretzky and Messier, call the play-by-play of some of hockey’s greatest goals, get up close and personal with the Stanley Cup in the museum’s vault, and explore the largest collection of hockey memorabilia in the world. Please note: this event requires the purchase of an event ticket for $100 USD. Be sure to select this registration option and plan to attend the premier social event of the 10th International ISSX Meeting.
President’s Message
New Members
Continued from page 1
Continued from page 4
of scholars. As past leaders of CSSX, Professor Zhou and Professor Liu were catalysts to the establishment and maintenance of a longstanding commitment to the collaboration between our two societies. Our continued support for China and the Asia Pacific region will continue next year at the Fifth Asia Pacific Regional ISSX Meeting to convene in Tianjin, China at the Crowne Plaza Tianjin Binhai Hotel May 9–12, 2014.
Lesley Murray, Genentech, United States Tomohisa Nakada, Mitsubishi Tanabe Pharma Corporation, Japan Zuzana Neumanova, Charles University In Prague, Faculty of Pharmacy, Czech Republic Winnie Ng, University of Toronto, Canada Nicholas Njuguna, University of Cape Town, South Africa Adenike Ogunshe, University of Ibadan, Nigeria Jiro Ogura, Hokkaido University, Japan Soo Jin Oh, Korea Research Institute of Bioscience and Biotechnology, Korea Maho Okubo, Showa Pharmaceutical University, Japan Olufunke Ola-Davies, University of Ibadan, Nigeria Jacob Olsen, Sanofi, Germany Chin Eng Ong, Monash University Malaysia, Malaysia Stefan Oswald, University of Greifswald Hyunseo Park, Lg Life Sciences, Ltd., Korea Kyung-Jin Park, Dong-A St Research Institute, Korea Alison Rodrigues, United Kingdom Fernando Rodrigues-Lima Ujjal Sarkar, Mit, United States Iain Shaw, Quotient Clinical, United Kingdom Eon-Jeong Shim, Inje University, Korea Hyunjoo Shim, Donga-St, Korea Kwang-Hee Shin, Seoul National University, Korea Lisl Shoda, Shoda Consulting, United States Amy Siu, Eisai, United States Lekha Sleno, Université du Québec à Montréal, Canada Sherri Smith, Infinity Pharmaceuticals, Inc., United States Masanori Tachikawa, Tohoku University, Japan Guoying Tai, GlaxoSmithKline, United States Masataka Tajima, International University of Health And Welfare, Japan Hidenori Takada, Kyowa Hakko Kirin Co., Ltd., Japan Susumu Takakuwa, Eisai Co., Ltd., Japan Nilay Thakkar, University of Kentucky, College of Pharmacy, United States Yaping Tu, GSK, United States Meera Tugnait, Ariad Pharmaceuticals, Inc., United States Jennifer Vanausdall, United States M Wahajuddin, Csir-Central Drug Research Institute, India Joe Walsh, Empiriko, United States Jing Wang, Labcyte, United States Ikumi Washio, Nippon Boehringer Ingelheim Co., Ltd., Japan Kensuke Watanabe, Hokkaido University Anneke Nina Werk, Institute For Experimental And Clinical Pharmacology at University Hospital Schleswig-Holstein, Germany Caroline Woodward, Ariad Pharmaceuticals, Inc., United States Wenjin Xiao, The University of Tokyo, Japan Yoshiyuki Yamaura Cuiping Yang, Beijing Institute of Pharmacology And Toxicology, China Tomoya Yasujima Yihua Ye, Ariad Pharmaceuticals, Inc., United States Kazuyoshi Yoshii, Zeria Pharmaceutical Co., Ltd., Japan Jiang Yue, Wuhan University, China Fagen Zhang, Toxicology And Environmental Research & Consulting, The Dow Chemical Company, United States Chunqi Zhu, Novartis, United States
ISSX and CSSX leaders recognize Chinese students for first awards for English presentations at the ISSX/CSSX Student Workshop held May 17–20, 2013 at Henan University in Kaifeng, Henan, PRC.
This closes the Spring/Summer President’s message. I would be negligent in my duties if I didn’t remind you to please take the time to renew your ISSX membership. I would really appreciate it! Finally, I hope to see you in Toronto, Canada for the 10th International ISSX Meeting September 29–October 3, 2013. Even though the first call for abstracts is closed, a second call for submissions is now open. It is certain to be an outstanding scientific meeting. Bill J. Smith ISSX President
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/ISSX Newsletter / Issue 2 2013
ISSX Member Spotlight What do you think the future of xenobiotic research will look like? What excites you about your research? What advice can you offer to students and young investigators? Answer these questions and you could be featured in our next newsletter. Complete the form online: www.issx.org/Membership/Spotlight
Change of Address
ISSX Newsletter is published quarterly in the spring, summer, autumn, and winter. For information concerning advertising in this publication, including rates and specifications, please visit www.issx.org or contact information@issx.org.
If your mailing address, telephone, fax number, or e-mail has changed or will change, please let us know as soon as possible. You may update your contact information at any time using the online membership directory, which you can access in the Member Only section of the Web site. If you have forgotten your username and/or password, please contact information@issx.org.
Advertise with ISSX in the quarterly ISSX Newsletter. Rates and additional advertising opportunities are available at www.issx.org/advertising.
Deadline for the submission* of material to the ISSX Office: ISSUE
MATERIALS DEADLINE
RELEASE DATE
Issue 3, 2013
July 12, 2013
August 2013
Issue 4, 2013
October 11, 2013
November 2013
*
Subject to change
Editor Dr. Allen Cato, III Cato Research, LTD 6480 Weathers Place, Suite 104 San Diego, California 92121 USA Telephone: +1-858-452-7271 Fax: +1-858-452-7784 E-mail: jcato@cato.com
Advertise with ISSX The quarterly ISSX Newsletter is an online publication featuring Society updates, scientific articles of interest, book reviews, summaries of ISSX meeting proceedings, and more. This publication is designed to update the ISSX membership on the activities and events of the organization and to provide an information forum. The ISSX Newsletter reaches every ISSX.org site visitor as well as the ISSX membership. Visit www.issx.org/advertising2013 today!
Issue 2, 2013
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