ISSX Newsletter Issue 4, 2013

Volume 33

Issue 4, 2013

ISSX President’s Message

By Bill J. Smith, ISSX President At the end of December my term comes to a close. It is a good time to reflect on the activities of the Society, challenges we face, and hopefully good decisions made that will have an impact on the future of ISSX. At the 2013 10th International ISSX Meeting, I thanked Officers and Council members who are also completing their terms in 2013. This included Charles Crespi (Treasurer), Brian Houston, and Ikumi Tamai.

During my term I served with Officers and Council members who will continue to serve or were reelected and this group included John Miners (President-Elect), Andrew Parkinson (Treasurer-Elect), Thomas Baillie, Ann Daly, Richard Kim, Paul Ortiz de Monellano, and Hiroshi Yamazaki.

Another important group to thank is the ISSX Office professionals at SmithBucklin which include Steve Kemp (Executive Director), Zoë Fuller, Kelly Marks, Alex Zapple, and Sarah Langan. This was a fantastic group of Officers, Council members, and ISSX staff to work with and I

offer my deepest gratitude for the opportunity to serve with them to do the Society’s important work. Finally, I want to offer my warm welcome to newly-elected Officers and Council members: Geoff Tucker (PresidentElect), James Halpert (TreasurerElect), Lawrence Marnett, and Maria Almira Correia. ISSX needs your experience, creativity, and passion.

With changes in the economy, the pharmaceutical industry, and funding for academia, ISSX had to adapt. It has taken a few years to reach a new steady state. During this time we experienced challenging times with a decline in membership and in the number of attendees at our meetings.

However, I am happy to report that all the indicators show that we have stabilized. During this time with the help of Charlie, Andrew, and Steve we have managed the Society’s finances in a way that meets the mission of ISSX and still retains a strong reserve fund for strategic investment in new initiatives and covers ISSX for unanticipated expenses. We used this

time of stability to develop a strategic plan for ISSX that is being implemented over the next 3-5 years. Key themes in the plan include increasing participation and member value, expanding scientific reach, increasing international scope, improving operational excellence, and improving financial sustainability. We have only just started on this plan, but my hope is that John Miners, the incoming President, and the new Council will continue this work.

Another job has been to plan new meetings for the future. Over my term, we added the 20th North American Meeting in Orlando, FL, USA (2015), 13th European Meeting in Glasgow, Scotland, UK (2015), and the 21st North American Meeting in Providence, RI, USA (2017) to the meeting calendar. The Orlando meeting will be chaired by Hartmut Derendorf (University of Florida), the Continued on page 10

IN THIS ISSUE 1

ISSX President’s Message

2

Book Review: Organic Chemicals in the Environment

3 5th Asia Pacific ISSX Meeting

8 Welcome New Members

5

North American ISSX/ 9 19th 29th JSSX Meeting

6

In Memoriam: Allan H. Conney In Memoriam: Ronald W. Estabrook

Book Review ORGANIC CHEMICALS IN THE ENVIRONMENT Mechanisms of Degradation and Transformation Authors: Alisdair H. Neilson and Ann-Sofie Allar CRC Press, Taylor & Francis Group, Florida, US. 1017pp, ISBN 978-1-4398-2637-9, 2013. 2nd edition.

and Interactions) which provide a broad perspective of chemical and biochemical reactions that a compound may undergo, whether assisted by biological catalysts or not. Perturbations brought about in microbes living in “stressful” situations (physical, chemical) and the potential metabolic consequences of this are also discussed.

As mentioned in the preface, “this volume deals primarily with organic chemicals in the aquatic and terrestrial environments, including products from atmospheric transformations” (page xxv). Now in its second edition, this large work is packed with useful and pertinent information concerning the potential fate of chemicals that have made their way, usually unintentionally, into the surrounding biosphere. Accepting that contamination or pollution frequently involves many different chemical entities, although one type may be present at higher concentration than the background plethora, the effects of this “chemical soup” on microorganisms are discussed.

Section two (Experimental Procedures), containing two chapters (Experimental procedures and Procedures for elucidation of metabolic pathways), describes practical techniques employed to investigate microbial populations, to establish metabolic pathways, and to determine the structure of metabolites produced.

2

/ISSX Newsletter / Issue 4, 2013

The book is conveniently divided into three sections. Section one (Degradation and Transformation Processes) contains four chapters (Abiotic reactions: An outline, Biotic reactions: An outline of reactions and organisms, Mechanisms,

The final section (Pathways and Mechanisms of Degradation and Transformation) gives details of biochemical reactions involved in the metabolic transformation of a range of substrate classes, with information concerning the enzymology involved.

Five chapters make up this larger section (Aliphatic compounds, Carbocyclic aromatic compounds without halogen substitution, Halogenated arenes and carboxylates with chlorine, bromine, or iodine substituents, Heterocyclic aromatic compounds and Miscellaneous compounds).

As is typical with such books, the layout is neat and the print easy to read. Many chemical schemes and copious references after (and within) each chapter add to the work. Good quality paper, firm binding, and an overall solid construction ensure that this book will remain durable for many years. For anyone with an interest in xenobiotics and environmental issues this book certainly is a useful reference source.

Reviewed by

Steve Mitchell Faculty of Medicine Imperial College London London SW7 2AZ, UK

Book ordering information:

CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW Suite 300 Boca Raton Florida 33487-2742 Unites States Taylor & Francis 2 Park Square Milton Park Abingdon Oxford OX14 4RN UK Web: http://www.taylorandfrancis.com http://www.crcpress.com

Upcoming Meetings 5th Asia Pacific ISSX Meeting Nankai University Tianjin, China May 9–12, 2014

19th North American/ 29th JSSX Meeting Hilton San Francisco San Francisco, California, USA October 19–23, 2014

13th European ISSX Meeting University of Strathclyde Glasgow, Scotland, UK June 21–25, 2015

20th North American ISSX Meeting Hilton Orlando Bonnet Creek Orlando, Florida, USA October 17–21, 2015

Issue 3, 2013

/ISSX Newsletter / 3

Save the Dates The 5th Asia Pacific ISSX Meeting will be held May 9 – 12, 2014 at Nankai University in Tianjin, China. The Scientific Program will be released in early 2014 and will include keynote presentations, workshop sessions, and symposia.

In addition to the top-­‐notch program, attendees are invited to submit abstracts and to nominate colleagues for the regional awards. Mark your calendar and plan to join colleagues and researchers from around the world for a memorable and educational meeting.

Meeting Organizing Committee Zhuohan Hu, Meeting Co-­‐Chair, Research Institute for Liver Disease, Shanghai, China John Miners, Meeting Co-­‐Chair, Flinders University School of Medicine, Adelaide Australia Changxiao Liu, Meeting Co-­‐Chair,Tianjin Institute of Pharmaceutical Research, Tianjin, China Phil Board, Australian National University, Canberra, Australia Min Huang, Zhongshan University, Sun Yat-­‐sen University, Guangzhou, China Jae-­‐Gook Shin, Inje University, Busan, Republic of Korea Duanyun Si, Tianjin Institute of Pharmaceutical Sciences, Tianjin, China Bill Smith, Pfizer Inc., San Diego, California, USA Jasminder Sahi, Life Technologies, Inc., Durham, North Carolina, USA Ikumi Tamai, Kanazawa University, Kanazawa, Japan Wichittra Tassaneeyakul, Khon Kaen University, Khon Kaen, Thailand Zhengqing Zhang, Chinese Academy of Military Medical Sciences, Beijing, China Dafang Zhong, Shanghai Institute of Materia Medica, Shanghai, China Mingshe Zhu, Bristol-­‐Myers Squibb, Princeton, New Jersey, USA

Abstract Submissions This meeting will provide the scientific community a wonderful opportunity to showcase work being done in a variety of areas and to network with other researchers. In addition to the general call for abstracts, it is tradition at ISSX meetings to recognize outstanding poster presentations by predoctoral and postdoctoral researchers.

Award winners receive a plaque and cash award.

Visit www.issx.org/5AP/Abstracts to submit a general or poster awards competition abstract for this meeting.

The abstract submission deadline is Friday, January 31, 2014 at 11:59 p.m. Eastern Time (U.S.)

Continued on next page

5th Asia Pacific ISSX Meeting Continued

4

/ISSX Newsletter / Issue 4, 2013

Call for Nominations Nominations are now being accepted for the awards to be presented at the 5th Asia Pacific ISSX Meeting. Visit www.issx.org/Awards/Nominations to submit a nomination. The two awards to be presented at this meeting are:

Asia Pacific Scientific Achievement Award -­‐ Presented to an ISSX member who has made major scientific contributions to the field in the Asia Pacific region. The purpose of this award is to recognize meritorious contributions by senior or mid-­‐career scientists that have had a major impact on research in the field. The award will consist of a plaque or medal, an honorarium, and travel support to the 5th Asia Pacific Meeting in Tianjin, China where a lecture will be presented by the awardee.

Regional New Investigator Award -­‐ Presented to an ISSX member who has made significant contributions to the field during their early career years (normally within 5-­‐10 years from the time of receiving his/her highest-­‐earned degree).

The purpose of this award is to encourage and recognize developing scientists who are active in the field within the Asia Pacific region. The award will consist of a plaque or medal, an honorarium, and travel support to the 5th Asia Pacific ISSX Meeting in Tianjin, China.

Nominations are due by Friday, March 14, 2014.

Support Opportunities Exhibit and sponsorship opportunities are still available for this meeting. Visit www.issx.org/5AP/Exhibits to learn more! www.issx.org/5AP We look forward to greeting you in Tianjin in May 2014.

Submit an abstract for the 5th Asia Pacific ISSX Meeting in Tianjin, China May 9–12, 2014 Visit www.issx.org/5AP/abstracts to submit an abstract. Abstract submissions for the general poster presentations and Poster Awards Competition are due by Friday, January 31, 2014.

IN MEMORIAM Allan H. Conney (1930-2013)

By Anthony Y.H. Lu (Rutgers University), C.S. Yang (Rutgers University), and F. Peter Guengerich (Vanderbilt University) Dr. Allan H. Conney, of Rutgers University, one of the most-cited scientists in pharmacology, cancer research, and drug metabolism, died on September 10, 2013 at the age of 83. Born in Chicago, Dr. Conney received his B.S. in pharmacy (1952) and his Ph.D. in oncology (1956) from the University of Wisconsin. Subsequently, he joined Dr. B.B. Brodie’s group at NIH to study enzyme induction and drug metabolism. From 1960 to 1987, he was affiliated with Burroughs-Wellcome and Hoffmann-La Roche. In 1987, Dr. Conney joined Rutgers University and established the Department of Chemical Biology at the Ernest Mario School of Pharmacy. He held the title of William and Myrle Garbe Professor of Cancer and Leukemia Research, State of New Jersey Professor of Pharmacology, and the Director of the Susan Lehman Cullman Laboratory for Cancer Research.

Since joining Rutgers University in 1987, Dr. Conney had devoted the last 26 years to cancer prevention research.

These studies include in vitro and in vivo experiments as well as clinical trials. In recent years, his laboratory discovered that caffeine and exercise inhibit skin carcinogenesis, and the combination of Lipitor and Celebrex inhibit prostate and pancreatic cancer progression. This body of work contributes greatly to our understanding of how cancer prevention can be achieved by simple steps and more acceptable lifestyle changes.

Dr. Conney had a very productive research career. He published more than 500 articles, many of which are very highly-cited. He was elected to the National Academy Sciences in 1982 and served as President of ASPET in 1983-1987. He was honored with many prestigious awards in pharmacology, pharmaceutical sciences, toxicology, and cancer research.

/ISSX Newsletter / 5

The fields of drug metabolism, pharmacology, and cancer research lost a good friend and a pioneering researcher.

He was a brilliant scientist and a wonderful person. He always treated his colleagues with respect and helped many individuals in their career development, particularly young researchers. We will always remember him as a warm, gentle, and scholarly friend.

Issue 4, 2013

Dr. Conney’s research work spanned over 50 years. He was still working on the day of his passing. He made major contributions to our basic knowledge of drug metabolism and the building of foundations of this area of research.

His illustrious research career began when he was a graduate student with Drs. James and Elizabeth Miller at the McArdle Institute. In studies on the investigation of the metabolism of carcinogenic aminoazo dyes and polycyclic aromatic hydrocarbons, he discovered the induction of xenobiotic-metabolizing enzymes in rats, believed to be the first demonstration of cytochrome P450 induction in mammals. In subsequent years at NIH, BurroughsWellcome, and Hoffmann-La Roche, he continued the work on enzyme induction and the influence of P450 induction and inhibition on the metabolism of therapeutic agents and carcinogens in animals and humans, long before drug-drug interactions were recognized as an important issue in drug discovery and development. His 1967 review article on “Pharmacological implications of microsomal enzyme induction” (Pharmacological Reviews, 19: 317366) was one of his most-cited articles in pharmacology in the 1960s and 1970s. During this period, he and his colleagues studied various factors regulating the metabolism of drugs, endogenous steroids and hormones, carcinogens, environmental chemicals, and the cytochrome P450 system. These studies contributed to the discovery of multiple forms of cytochrome P450 enzymes and eventually the purification and characterization of many P450 enzymes. A more detailed account of this work can

be found in his 2003 review article on “Induction of drugmetabolizing enzymes: a path to the discovery of multiple cytochromes P450” (Annu. Rev. Pharmacol. Toxicol.

43:1-30). Another important milestone in Dr. Conney’s research was the collaborative studies with Dr. Don Jerina of NIH on the metabolism and carcinogenesis of polycyclic aromatic hydrocarbons. The NIH team and the Roche group made the most thorough and systemic studies on the metabolism, mutagenesis, and carcinogenesis of many of the metabolites of a number of polycyclic aromatic hydrocarbons. These studies led to the establishment of the bay region diol epoxide theory to explain the carcinogenesis of this class of compounds.

IN MEMORIAM Ronald W. Estabrook (1926-2013) It is with sadness that ISSX announces the passing of Ronald W. Estabrook, Professor Emeritus, Department of Biochemistry, UT Southwestern Medical Center.

A pioneer in the study on the cytochromes of mitochondria, DMPK, Ronald W. Estabrook was a member of the ISSX Council from 1984 to 1987. He was elected as the fourth President of ISSX, serving in that position from 1988 – 1989. He remained involved in ISSX matters long after his term ended and attended many Council meetings as Past-President and advisor to the Society. He was an ardent photographer and was the unofficial historian of ISSX. His online catalog of photographs from ISSX meetings and other events is extensive.

Dr. Estabrook received his undergraduate degree from the Rensselaer Polytechnic Institute in 1950. He earned his Ph.D. from the Rochester Institute of Technology in 1954.

His first breakthrough was as a professor at the University of Pennsylvania, when he and two colleagues discovered the properties of a hemoprotein molecule known as cytochrome P450, demonstrating that P450 plays a crucial role in how the body metabolizes various substances.

6

/ISSX Newsletter / Issue 4, 2013

To honor his service to ISSX and his scientific achievements, XenoTech permanently endowed the North American Scientific Achievement Award in Honor of Ronald W. Estabrook. Dr. Estabrook himself was one of the first scientists ever honored by ISSX. In 2001 he was presented with the ISSX Award for Distinguished Service, as it was previously named.

Dr. Ronald W. Estabook was born in Albany, NY on January 3, 1926. When he was 17, he left New York to join the Navy, attending officer’s training school at Princeton, and then serving as navigator on a ship sweeping minefields.

The young mine sweeper then returned to school and earned a doctorate in biochemistry from the University of Rochester.

He would go on to become an eminent researcher, chairman of biochemistry at UT Southwestern for 14 years, and the first dean of UT Southwestern Graduate School of Biomedical Sciences. He played a major role in turning UT Southwestern into an internationally-respected research center that would attract many of the nation’s brightest and best scientists and students.

In 2006, at the age of 80 years, Dr. Estabrook retired and was named the University of Texas System Ashbel Smith Emeritus Professor Biochemistry. He will be fondly remembered by his many colleagues, students, friends, his wife June, and his children and grandchildren.

ISSX 18th North American Meeting Awards Pictured Left to Right: XenoTech Chief Scientific Officer, David Buckley; North American New Investigator Award in Honor of James R. Gillette Winner, Emily Scott; Ronald Estabrook; Scientific Achievement Award in Honor of Ronald Estabrook, Sponsored by XenoTech Winner, R. Scott Obach; and ISSX Awards Committee Chair, John Miners.

ISSX members have access to a variety of exclusive benefits including: A Subscription to the ISSX Newsletter -­‐ Members receive a quarterly newsletter that highlights Society news, member spotlights, upcoming meetings, late breaking scientific news, and much more.

Reduced Registration Fees -­‐ Members receive significant discounts on registration fees for all ISSX meetings and workshops.

Recorded Educational Content -­‐ New in 2014 -­‐ Members can access recorded content online at a reduced members-­‐only rate.

Abstract Presentations -­‐ Members have the opportunity to submit abstracts to present their work with other leaders in the field at ISSX meetings.

Searchable Meeting Abstracts -­‐ Members may perform searches for and cite abstracts from past ISSX meetings.

Networking Opportunities -­‐ Meet with other local and international leaders interested in DMPK. Society Awards Program -­‐ Only ISSX members are eligible for the prestigious Scientific Achievement Awards presented at our regional meetings.

Travel Grants -­‐ Eligible members may apply for travel assistance to attend ISSX regional and international meetings.

Membership Directory -­‐ Our searchable online membership directory makes connecting with fellow researchers convenient.

Special Journal Subscription Discounts -­‐ Members receive special subscription discounts to multiple scientific journals, including Drug Metabolism Reviews, Annual Review of Pharmacology and Toxicology, and many more.

Hold Office and Serve on a Committee -­‐ Holding a position of leadership in ISSX is a tremendous opportunity to serve your peers worldwide, to develop important skills, help set the work plan of a prestigious international scientific society, and be recognized as a leader volunteer of an international scientific society.

Vote in ISSX Elections -­‐ Helping to choose the future leaders of ISSX sets the path of our organization and provides you the opportunity to elect those who best represent your interests.

Most of all, your membership indicates your support of our mission to advance the understanding of the interactions of medicines and chemicals with living systems and helps sustain our program of operations. Please support ISSX by renewing your membership today!

www.issx.org/membership/renew

ISSX Welcomes New 2013 Members!

Adeolu Adedapo, University of Ibadan, Nigeria Daniel Antoine, University of Liverpool, United Kingdom

Jason Neat, XenoTech, LLC, United States

Rieko Arimoto, Vertex Pharmaceuticals, Inc., United States

Shinichi Ninomiya, Sekisui Medical Co., Ltd., Japan

Evan Comeaux, United States

Chiho Ono, Pfizer Japan Inc., Japan

Jason Deloach, HTG Molecular Diagnostics, United States

M.V.S. Rao, Advinus Therapeutics Limited, India

Reema Deol, University of Guelph, Canada

Steven Reid, In Vitro ADMET Laboratories, LLC. (IVAL), United States

/ISSX Newsletter / Issue 4, 2013

Matthew Dufek, Abbvie, United States

8

Kiyoshi Natsui, Dainippon Sumitomo Pharma Co., Ltd, Japan

Viviana Figueroa, University of Havana, Cuba

Stephan Schmidt, University of Florida - Orlando, United States

Girish Gudi, Glenmark Pharmaceuticals Ltd., India

Aaron Shapiro, University of Toronto, Canada

Hyun Gung Jang, Ariad Pharmaceuticals, United States

Jose Silva, Janssen, United States

Kajaparan Jeyanthan, University of Guelph, Canada

Inese Smukste, Corning Inc., United States

Vinay K, Syngene International Ltd., India

Jonathan Stauber, Imabiotech, France

Won Ho Kang, Daewoong Pharmaceutical company, Korea, South

Ihrene Supapo, Novartis Institutes of BioMedical Research, United States

Tae-Sung Koo, Chungnam National University, Korea

Hui Tang, University of Toronto, Canada

Pamela Loughran, University of Guelph, Canada

Jean-Francois Tetu, Tebu-Bio, France

Jiyuan Ma, PTC Therapeutics, Inc., United States

Sarah Woody, University of Kansas, United States

Carol Marchant, Lhasa Limited, United Kingdom

Jiekun Xuan, National Center For Toxicological Research, USFDA, United States

Submit an abstract for the 5th Asia Pacific Regional ISSX Meeting in Tianjin, China May 9–12, 2014.

Visit www.issx.org/5AP/abstracts to submit an abstract. Abstract submissions for the general poster presentations and Poster Awards Competition are due by Friday, January 31, 2014.

ISSX 2014 Membership Support ISSX! Renew with ISSX for the 2014 Membership term! www.issx.org/renew.

Join the Japanese Society for the Study of Xenobiotics (JSSX) and the International Society for the Study of Xenobiotics (ISSX) at a joint scientific meeting October 19 – 23, 2014 in San Francisco, California, USA.

Meeting Organizing Committee

Tetsuya Terasaki, PhD (Meeting Co-­‐Chair) Tohoku University

Eric Johnson, PhD (Meeting Co-­‐Chair) The Scripps Research Institute

Toshio Teramura, PhD Astellas Pharma, Inc.

Kan Chiba, PhD Chiba University

Natilie Hosea, PhD Pfizer Inc.

Takashi Izumi, PhD Daiichi Sankyo Co., Ltd.

Mikihisa Takano, PhD Hiroshima University

Ikumi Tamai, PhD Kanazawa University

Bill Smith, PhD Pfizer Inc., La Jolla Labs

Frank Gonzalez, PhD National Cancer Institute

R. Scott Obach, PhD Pfizer Inc.

Hiroshi Yamazaki, PhD Showa Pharmaceutical University

Hiroshi Suzuki, PhD The University of Tokyo Hospital

Paul Ortiz de Montellano, PhD University of California, San Francisco

Peter W. Swaan, PhD University of Maryland

Xiao-­‐bo Zhong, PhD University of Connecticut School of Pharmacy

Features of this Meeting

This meeting will feature short courses, keynote lectures delivered by leading researchers, parallel sessions, poster sessions, awards presentations, a vendor exhibition, and multiple opportunities for attendees to enjoy social interaction with friends, acquaintances, and other meeting attendees.

Meeting Venue

With its prime location near Nob Hill and Chinatown,

the Hilton San Francisco Union Square provides easy access to all that San Francisco has to offer.

San Francisco is renowned for its steep rolling hills, eclectic architecture, and landmarks including the Golden Gate Bridge, cable cars, the famous Lombard Street, Alcatraz and much more.

Its international airport is a major gateway to Asia with direct flights from more than 40 countries daily.

Save the Date and Make Plans to Join us in San Francisco October 19 – 23, 2014

President’s Message Continued from page 1

Glasgow meeting will be co-chaired by Roland Wolf (University of Dundee) and Ann Daly (Newcastle University), and finally the Providence meeting chair will be Jashvant Unadkat (University of Washington). We have great chairs and meeting organizing committees to develop terrific programs for these upcoming meetings. I look forward to seeing these conferences take shape and attending them myself in a few years.

Another passion during my term has been to support the international mission of ISSX. During my terms as Secretary, President-Elect, and President I have been a strong supporter of the growth of ISSX in the AsiaPacific region. A key focus was developing sustained relations with the leaders of our affiliate organization, the Chinese Society for the Study of Xenobiotics (CSSX).

I helped organize and participated in workshops and conferences with CSSX in Shanghai, Guangzhou, Xi’an, Tianjin, Nanjing, and Kaifeng from 2010-2013. I am proud that I was able to contribute to the vision of ISSX PastPresident, Yuichi Sugiyama, to grow the activity of ISSX in China and the AP region. Additionally, we recently started work in India on a small scale to build our presence in a country where there are many scientists in universities and companies interested in xenobiotic research.

In closing my final ISSX Newsletter contribution, I want to say that it has been a privilege to serve the ISSX membership during my term. I will cherish the memories of all the new friendships formed, exciting events, and even the occasional stressful situations I encountered during my term. I look forward to the future meetings of ISSX and I hope we can meet to discuss interesting scientific developments in the fields of xenobiotic research.

10

/ISSX Newsletter / Issue 4 2013

All the best, Bill J. Smith ISSX President

ISSX 2014 Membership Support ISSX! Renew with ISSX for the 2014 Membership term! www.issx.org/renew.

Do you know about the ISSX Career Center?

Searching for experts in the field of drug metabolism, pharmacokinetics, pharmacodynamics, and other related areas? The ISSX Career Center job board is your premier resource to find skilled applicants.

•C reate your company profile free of charge and explain the organization and work environment in detail.

•W hen your positions are advertised on the ISSX Career Center, an e-mail advertising the position is sent automatically to job seekers who have requested notifications about opportunities matching their search criteria.

•B rowse résumés for free and pay only for the résumés that you select.

Post your jobs online today! When you use the ISSX Career Center, you ensure that your open positions are advertised in the right place. Visit www.issx.org/careercenter.

Submit an Abstract for the 19th North American ISSX and 29th JSSX Meeting in San Francisco, California October 19–23, 2014 The Call for Abstracts opens Monday, January 6! Present your work and network with fellow researchers. This meeting also features a predoctoral and postdoctoral poster awards competition as well as opportunities for poster authors to give brief podium presentations.

Change of Address

ISSX Newsletter is published quarterly in the spring, summer, autumn, and winter. For information concerning advertising in this publication, including rates and specifications, please visit www.issx.org or contact information@issx.org.

If your mailing address, telephone, fax number, or e-mail has changed or will change, please let us know as soon as possible. You may update your contact information at any time using the online membership directory, which you can access in the Member Only section of the Web site. If you have forgotten your username and/or password, please contact information@issx.org.

Advertise with ISSX in the quarterly ISSX Newsletter.

Rates and additional advertising opportunities are available at www.issx.org/advertising2014.

Deadline for the submission* of material to the ISSX Office: ISSUE

MATERIALS DEADLINE

RELEASE DATE

Issue 1, 2014

February 14, 2014

March 2014

Issue 2, 2014

May 16, 2014

June 2014

Pre-Meeting Issue

August 15, 2014

September 2014

Issue 4, 2014

November 14, 2014

December 2014

*

Subject to change

Editor Dr. Allen Cato, III Cato Research, LTD 6480 Weathers Place, Suite 104 San Diego, California 92121 USA Telephone: +1-858-452-7271 Fax: +1-858-452-7784 E-mail: jcato@cato.com

Advertise with ISSX The quarterly ISSX Newsletter is an online publication featuring Society updates, scientific articles of interest, book reviews, summaries of ISSX meeting proceedings, and more. This publication is designed to update the ISSX membership on the activities and events of the organization and to provide an information forum.

Not only is the ISSX Newsletter promoted directly to all ISSX Members, but, as of 2012, it is also available to anyone who visits the ISSX Web site.

Visit www.issx.org/advertising2014 today!

Issue 4, 2013

/ISSX Newsletter / 11