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Volume 33

Issue 4, 2013

ISSX President’s Message By Bill J. Smith, ISSX President At the end of December my term comes to a close. It is a good time to reflect on the activities of the Society, challenges we face, and hopefully good decisions made that will have an impact on the future of ISSX. At the 2013 10th International ISSX Meeting, I thanked Officers and Council members who are also completing their terms in 2013. This included Charles Crespi (Treasurer), Brian Houston, and Ikumi Tamai. During my term I served with Officers and Council members who will continue to serve or were reelected and this group included John Miners (President-Elect), Andrew Parkinson (Treasurer-Elect), Thomas Baillie, Ann Daly, Richard Kim, Paul Ortiz de Monellano, and Hiroshi Yamazaki. Another important group to thank is the ISSX Office professionals at SmithBucklin which include Steve Kemp (Executive Director), Zoë Fuller, Kelly Marks, Alex Zapple, and Sarah Langan. This was a fantastic group of Officers, Council members, and ISSX staff to work with and I

offer my deepest gratitude for the opportunity to serve with them to do the Society’s important work. Finally, I want to offer my warm welcome to newly-elected Officers and Council members: Geoff Tucker (PresidentElect), James Halpert (TreasurerElect), Lawrence Marnett, and Maria Almira Correia. ISSX needs your experience, creativity, and passion. With changes in the economy, the pharmaceutical industry, and funding for academia, ISSX had to adapt. It has taken a few years to reach a new steady state. During this time we experienced challenging times with a decline in membership and in the number of attendees at our meetings. However, I am happy to report that all the indicators show that we have stabilized. During this time with the help of Charlie, Andrew, and Steve we have managed the Society’s finances in a way that meets the mission of ISSX and still retains a strong reserve fund for strategic investment in new initiatives and covers ISSX for unanticipated expenses. We used this

time of stability to develop a strategic plan for ISSX that is being implemented over the next 3-5 years. Key themes in the plan include increasing participation and member value, expanding scientific reach, increasing international scope, improving operational excellence, and improving financial sustainability. We have only just started on this plan, but my hope is that John Miners, the incoming President, and the new Council will continue this work. Another job has been to plan new meetings for the future. Over my term, we added the 20th North American Meeting in Orlando, FL, USA (2015), 13th European Meeting in Glasgow, Scotland, UK (2015), and the 21st North American Meeting in Providence, RI, USA (2017) to the meeting calendar. The Orlando meeting will be chaired by Hartmut Derendorf (University of Florida), the Continued on page 10


ISSX President’s Message


Book Review: Organic Chemicals in the Environment

3 5th Asia Pacific ISSX Meeting

8 Welcome New Members


North American ISSX/ 9 19th 29th JSSX Meeting


In Memoriam: Allan H. Conney In Memoriam: Ronald W. Estabrook

Book Review ORGANIC CHEMICALS IN THE ENVIRONMENT Mechanisms of Degradation and Transformation Authors: Alisdair H. Neilson and Ann-Sofie Allar CRC Press, Taylor & Francis Group, Florida, US. 1017pp, ISBN 978-1-4398-2637-9, 2013. 2nd edition.

and Interactions) which provide a broad perspective of chemical and biochemical reactions that a compound may undergo, whether assisted by biological catalysts or not. Perturbations brought about in microbes living in “stressful” situations (physical, chemical) and the potential metabolic consequences of this are also discussed.

As mentioned in the preface, “this volume deals primarily with organic chemicals in the aquatic and terrestrial environments, including products from atmospheric transformations” (page xxv). Now in its second edition, this large work is packed with useful and pertinent information concerning the potential fate of chemicals that have made their way, usually unintentionally, into the surrounding biosphere. Accepting that contamination or pollution frequently involves many different chemical entities, although one type may be present at higher concentration than the background plethora, the effects of this “chemical soup” on microorganisms are discussed.

Section two (Experimental Procedures), containing two chapters (Experimental procedures and Procedures for elucidation of metabolic pathways), describes practical techniques employed to investigate microbial populations, to establish metabolic pathways, and to determine the structure of metabolites produced.


/ISSX Newsletter / Issue 4, 2013

The book is conveniently divided into three sections. Section one (Degradation and Transformation Processes) contains four chapters (Abiotic reactions: An outline, Biotic reactions: An outline of reactions and organisms, Mechanisms,

The final section (Pathways and Mechanisms of Degradation and Transformation) gives details of biochemical reactions involved in the metabolic transformation of a range of substrate classes, with information concerning the enzymology involved. Five chapters make up this larger section (Aliphatic compounds, Carbocyclic aromatic compounds without halogen substitution, Halogenated arenes and carboxylates with chlorine, bromine, or iodine substituents, Heterocyclic aromatic compounds and Miscellaneous compounds).

As is typical with such books, the layout is neat and the print easy to read. Many chemical schemes and copious references after (and within) each chapter add to the work. Good quality paper, firm binding, and an overall solid construction ensure that this book will remain durable for many years. For anyone with an interest in xenobiotics and environmental issues this book certainly is a useful reference source.

Reviewed by

Steve Mitchell Faculty of Medicine Imperial College London London SW7 2AZ, UK

Book ordering information:

CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW Suite 300 Boca Raton Florida 33487-2742 Unites States Taylor & Francis 2 Park Square Milton Park Abingdon Oxford OX14 4RN UK Web:

Upcoming Meetings 5th Asia Pacific ISSX Meeting Nankai University Tianjin, China May 9–12, 2014

19th North American/ 29th JSSX Meeting Hilton San Francisco San Francisco, California, USA October 19–23, 2014

13th European ISSX Meeting University of Strathclyde Glasgow, Scotland, UK June 21–25, 2015

20th North American ISSX Meeting Hilton Orlando Bonnet Creek Orlando, Florida, USA October 17–21, 2015

Issue 3, 2013

/ISSX Newsletter / 3

Save the  Dates   The  5th  Asia  Pacific  ISSX  Meeting  will  be  held  May  9  –  12,  2014  at  Nankai  University  in  Tianjin,  China.    The  Scientific   Program  will  be  released  in  early  2014  and  will  include  keynote  presentations,  workshop  sessions,  and  symposia.     In  addition  to  the  top-­‐notch  program,  attendees  are  invited  to  submit  abstracts  and  to  nominate  colleagues  for     the  regional  awards.    Mark  your  calendar  and  plan  to  join  colleagues  and  researchers  from  around  the  world  for     a  memorable  and  educational  meeting.         Meeting  Organizing  Committee   Zhuohan  Hu,  Meeting  Co-­‐Chair,  Research  Institute  for  Liver  Disease,  Shanghai,  China   John  Miners,  Meeting  Co-­‐Chair,  Flinders  University  School  of  Medicine,  Adelaide  Australia   Changxiao  Liu,  Meeting  Co-­‐Chair,Tianjin  Institute  of  Pharmaceutical  Research,  Tianjin,  China   Phil  Board,  Australian  National  University,  Canberra,  Australia   Min  Huang,  Zhongshan  University,  Sun  Yat-­‐sen  University,  Guangzhou,  China   Jae-­‐Gook  Shin,  Inje  University,  Busan,  Republic  of  Korea   Duanyun  Si,  Tianjin  Institute  of  Pharmaceutical  Sciences,  Tianjin,  China   Bill  Smith,  Pfizer  Inc.,  San  Diego,  California,  USA   Jasminder  Sahi,  Life  Technologies,  Inc.,  Durham,  North  Carolina,  USA   Ikumi  Tamai,  Kanazawa  University,  Kanazawa,  Japan   Wichittra  Tassaneeyakul,  Khon  Kaen  University,  Khon  Kaen,  Thailand   Zhengqing  Zhang,  Chinese  Academy  of  Military  Medical  Sciences,  Beijing,  China   Dafang  Zhong,  Shanghai  Institute  of  Materia  Medica,  Shanghai,  China   Mingshe  Zhu,  Bristol-­‐Myers  Squibb,  Princeton,  New  Jersey,  USA         Abstract  Submissions   This  meeting  will  provide  the  scientific  community  a  wonderful  opportunity  to  showcase  work  being  done  in  a   variety  of  areas  and  to  network  with  other  researchers.    In  addition  to  the  general  call  for  abstracts,  it  is  tradition   at  ISSX  meetings  to  recognize  outstanding  poster  presentations  by  predoctoral  and  postdoctoral  researchers.       Award  winners  receive  a  plaque  and  cash  award.         Visit  to  submit  a  general  or  poster  awards  competition  abstract  for  this  meeting.     The  abstract  submission  deadline  is  Friday,  January  31,  2014  at  11:59  p.m.  Eastern  Time  (U.S.)           Continued on next page

5th Asia Pacific ISSX Meeting Continued


/ISSX Newsletter / Issue 4, 2013

Call for  Nominations   Nominations  are  now  being  accepted  for  the  awards  to  be  presented  at  the  5th  Asia  Pacific  ISSX  Meeting.    Visit  to  submit  a  nomination.    The  two  awards  to  be  presented  at  this  meeting  are:     Asia  Pacific  Scientific  Achievement  Award  -­‐  Presented  to  an  ISSX  member  who  has  made  major  scientific   contributions  to  the  field  in  the  Asia  Pacific  region.    The  purpose  of  this  award  is  to  recognize  meritorious   contributions  by  senior  or  mid-­‐career  scientists  that  have  had  a  major  impact  on  research  in  the  field.  The  award     will  consist  of  a  plaque  or  medal,  an  honorarium,  and  travel  support  to  the  5th  Asia  Pacific  Meeting  in  Tianjin,     China  where  a  lecture  will  be  presented  by  the  awardee.       Regional  New  Investigator  Award  -­‐  Presented  to  an  ISSX  member  who  has  made  significant  contributions  to  the  field   during  their  early  career  years  (normally  within  5-­‐10  years  from  the  time  of  receiving  his/her  highest-­‐earned  degree).   The  purpose  of  this  award  is  to  encourage  and  recognize  developing  scientists  who  are  active  in  the  field  within  the   Asia  Pacific  region.    The  award  will  consist  of  a  plaque  or  medal,  an  honorarium,  and  travel  support  to  the  5th  Asia   Pacific  ISSX  Meeting  in  Tianjin,  China.       Nominations  are  due  by  Friday,  March  14,  2014.           Support  Opportunities   Exhibit  and  sponsorship  opportunities  are  still  available  for  this  meeting.    Visit  to  learn   more!    We  look  forward  to  greeting  you  in  Tianjin  in  May  2014.        

Submit an abstract for the 5th Asia Pacific ISSX Meeting in Tianjin, China May 9–12, 2014 Visit to submit an abstract. Abstract submissions for the general poster presentations and Poster Awards Competition are due by Friday, January 31, 2014.

IN MEMORIAM Allan H. Conney (1930-2013) By Anthony Y.H. Lu (Rutgers University), C.S. Yang (Rutgers University), and F. Peter Guengerich (Vanderbilt University) Dr. Allan H. Conney, of Rutgers University, one of the most-cited scientists in pharmacology, cancer research, and drug metabolism, died on September 10, 2013 at the age of 83. Born in Chicago, Dr. Conney received his B.S. in pharmacy (1952) and his Ph.D. in oncology (1956) from the University of Wisconsin. Subsequently, he joined Dr. B.B. Brodie’s group at NIH to study enzyme induction and drug metabolism. From 1960 to 1987, he was affiliated with Burroughs-Wellcome and Hoffmann-La Roche. In 1987, Dr. Conney joined Rutgers University and established the Department of Chemical Biology at the Ernest Mario School of Pharmacy. He held the title of William and Myrle Garbe Professor of Cancer and Leukemia Research, State of New Jersey Professor of Pharmacology, and the Director of the Susan Lehman Cullman Laboratory for Cancer Research.

Since joining Rutgers University in 1987, Dr. Conney had devoted the last 26 years to cancer prevention research. These studies include in vitro and in vivo experiments as well as clinical trials. In recent years, his laboratory discovered that caffeine and exercise inhibit skin carcinogenesis, and the combination of Lipitor and Celebrex inhibit prostate and pancreatic cancer progression. This body of work contributes greatly to our understanding of how cancer prevention can be achieved by simple steps and more acceptable lifestyle changes. Dr. Conney had a very productive research career. He published more than 500 articles, many of which are very highly-cited. He was elected to the National Academy Sciences in 1982 and served as President of ASPET in 1983-1987. He was honored with many prestigious awards in pharmacology, pharmaceutical sciences, toxicology, and cancer research.

/ISSX Newsletter / 5

The fields of drug metabolism, pharmacology, and cancer research lost a good friend and a pioneering researcher. He was a brilliant scientist and a wonderful person. He always treated his colleagues with respect and helped many individuals in their career development, particularly young researchers. We will always remember him as a warm, gentle, and scholarly friend.

Issue 4, 2013

Dr. Conney’s research work spanned over 50 years. He was still working on the day of his passing. He made major contributions to our basic knowledge of drug metabolism and the building of foundations of this area of research. His illustrious research career began when he was a graduate student with Drs. James and Elizabeth Miller at the McArdle Institute. In studies on the investigation of the metabolism of carcinogenic aminoazo dyes and polycyclic aromatic hydrocarbons, he discovered the induction of xenobiotic-metabolizing enzymes in rats, believed to be the first demonstration of cytochrome P450 induction in mammals. In subsequent years at NIH, BurroughsWellcome, and Hoffmann-La Roche, he continued the work on enzyme induction and the influence of P450 induction and inhibition on the metabolism of therapeutic agents and carcinogens in animals and humans, long before drug-drug interactions were recognized as an important issue in drug discovery and development. His 1967 review article on “Pharmacological implications of microsomal enzyme induction” (Pharmacological Reviews, 19: 317366) was one of his most-cited articles in pharmacology in the 1960s and 1970s. During this period, he and his colleagues studied various factors regulating the metabolism of drugs, endogenous steroids and hormones, carcinogens, environmental chemicals, and the cytochrome P450 system. These studies contributed to the discovery of multiple forms of cytochrome P450 enzymes and eventually the purification and characterization of many P450 enzymes. A more detailed account of this work can

be found in his 2003 review article on “Induction of drugmetabolizing enzymes: a path to the discovery of multiple cytochromes P450” (Annu. Rev. Pharmacol. Toxicol. 43:1-30). Another important milestone in Dr. Conney’s research was the collaborative studies with Dr. Don Jerina of NIH on the metabolism and carcinogenesis of polycyclic aromatic hydrocarbons. The NIH team and the Roche group made the most thorough and systemic studies on the metabolism, mutagenesis, and carcinogenesis of many of the metabolites of a number of polycyclic aromatic hydrocarbons. These studies led to the establishment of the bay region diol epoxide theory to explain the carcinogenesis of this class of compounds.

IN MEMORIAM Ronald W. Estabrook (1926-2013) It is with sadness that ISSX announces the passing of Ronald W. Estabrook, Professor Emeritus, Department of Biochemistry, UT Southwestern Medical Center. A pioneer in the study on the cytochromes of mitochondria, DMPK, Ronald W. Estabrook was a member of the ISSX Council from 1984 to 1987. He was elected as the fourth President of ISSX, serving in that position from 1988 – 1989. He remained involved in ISSX matters long after his term ended and attended many Council meetings as Past-President and advisor to the Society. He was an ardent photographer and was the unofficial historian of ISSX. His online catalog of photographs from ISSX meetings and other events is extensive. Dr. Estabrook received his undergraduate degree from the Rensselaer Polytechnic Institute in 1950. He earned his Ph.D. from the Rochester Institute of Technology in 1954. His first breakthrough was as a professor at the University of Pennsylvania, when he and two colleagues discovered the properties of a hemoprotein molecule known as cytochrome P450, demonstrating that P450 plays a crucial role in how the body metabolizes various substances.


/ISSX Newsletter / Issue 4, 2013

To honor his service to ISSX and his scientific achievements, XenoTech permanently endowed the North American Scientific Achievement Award in Honor of Ronald W. Estabrook. Dr. Estabrook himself was one of the first scientists ever honored by ISSX. In 2001 he was presented with the ISSX Award for Distinguished Service, as it was previously named.

Dr. Ronald W. Estabook was born in Albany, NY on January 3, 1926. When he was 17, he left New York to join the Navy, attending officer’s training school at Princeton, and then serving as navigator on a ship sweeping minefields. The young mine sweeper then returned to school and earned a doctorate in biochemistry from the University of Rochester. He would go on to become an eminent researcher, chairman of biochemistry at UT Southwestern for 14 years, and the first dean of UT Southwestern Graduate School of Biomedical Sciences. He played a major role in turning UT Southwestern into an internationally-respected research center that would attract many of the nation’s brightest and best scientists and students. In 2006, at the age of 80 years, Dr. Estabrook retired and was named the University of Texas System Ashbel Smith Emeritus Professor Biochemistry. He will be fondly remembered by his many colleagues, students, friends, his wife June, and his children and grandchildren.

ISSX 18th North American Meeting Awards Pictured Left to Right: XenoTech Chief Scientific Officer, David Buckley; North American New Investigator Award in Honor of James R. Gillette Winner, Emily Scott; Ronald Estabrook; Scientific Achievement Award in Honor of Ronald Estabrook, Sponsored by XenoTech Winner, R. Scott Obach; and ISSX Awards Committee Chair, John Miners.

ISSX members  have  access  to  a  variety  of  exclusive  benefits  including:   A  Subscription  to  the  ISSX  Newsletter  -­‐  Members  receive  a  quarterly  newsletter  that  highlights  Society  news,   member  spotlights,  upcoming  meetings,  late  breaking  scientific  news,  and  much  more.   Reduced  Registration  Fees  -­‐  Members  receive  significant  discounts  on  registration  fees  for  all  ISSX  meetings   and  workshops.   Recorded  Educational  Content  -­‐  New  in  2014  -­‐  Members  can  access  recorded  content  online  at  a  reduced   members-­‐only  rate.   Abstract  Presentations  -­‐  Members  have  the  opportunity  to  submit  abstracts  to  present  their  work  with  other   leaders  in  the  field  at  ISSX  meetings.   Searchable  Meeting  Abstracts  -­‐  Members  may  perform  searches  for  and  cite  abstracts  from  past  ISSX   meetings.     Networking  Opportunities  -­‐  Meet  with  other  local  and  international  leaders  interested  in  DMPK.   Society  Awards  Program  -­‐  Only  ISSX  members  are  eligible  for  the  prestigious  Scientific  Achievement  Awards   presented  at  our  regional  meetings.   Travel  Grants  -­‐  Eligible  members  may  apply  for  travel  assistance  to  attend  ISSX  regional  and  international   meetings.   Membership  Directory  -­‐  Our  searchable  online  membership  directory  makes  connecting  with  fellow   researchers  convenient.   Special  Journal  Subscription  Discounts  -­‐  Members  receive  special  subscription  discounts  to  multiple  scientific   journals,  including  Drug  Metabolism  Reviews,  Annual  Review  of  Pharmacology  and  Toxicology,  and  many   more.     Hold  Office  and  Serve  on  a  Committee  -­‐  Holding  a  position  of  leadership  in  ISSX  is  a  tremendous  opportunity   to  serve  your  peers  worldwide,  to  develop  important  skills,  help  set  the  work  plan  of  a  prestigious  international   scientific  society,  and  be  recognized  as  a  leader  volunteer  of  an  international  scientific  society.   Vote  in  ISSX  Elections  -­‐  Helping  to  choose  the  future  leaders  of  ISSX  sets  the  path  of  our  organization  and   provides  you  the  opportunity  to  elect  those  who  best  represent  your  interests.         Most   of  all,  your  membership  indicates  your  support  of  our  mission  to  advance  the  understanding  of   the  interactions  of  medicines  and  chemicals  with  living  systems  and  helps  sustain  our  program  of   operations.    Please  support  ISSX  by  renewing  your  membership  today!

ISSX Welcomes New 2013 Members! Adeolu Adedapo, University of Ibadan, Nigeria Daniel Antoine, University of Liverpool, United Kingdom

Jason Neat, XenoTech, LLC, United States

Rieko Arimoto, Vertex Pharmaceuticals, Inc., United States

Shinichi Ninomiya, Sekisui Medical Co., Ltd., Japan

Evan Comeaux, United States

Chiho Ono, Pfizer Japan Inc., Japan

Jason Deloach, HTG Molecular Diagnostics, United States

M.V.S. Rao, Advinus Therapeutics Limited, India

Reema Deol, University of Guelph, Canada

Steven Reid, In Vitro ADMET Laboratories, LLC. (IVAL), United States

/ISSX Newsletter / Issue 4, 2013

Matthew Dufek, Abbvie, United States


Kiyoshi Natsui, Dainippon Sumitomo Pharma Co., Ltd, Japan

Viviana Figueroa, University of Havana, Cuba

Stephan Schmidt, University of Florida - Orlando, United States

Girish Gudi, Glenmark Pharmaceuticals Ltd., India

Aaron Shapiro, University of Toronto, Canada

Hyun Gung Jang, Ariad Pharmaceuticals, United States

Jose Silva, Janssen, United States

Kajaparan Jeyanthan, University of Guelph, Canada

Inese Smukste, Corning Inc., United States

Vinay K, Syngene International Ltd., India

Jonathan Stauber, Imabiotech, France

Won Ho Kang, Daewoong Pharmaceutical company, Korea, South

Ihrene Supapo, Novartis Institutes of BioMedical Research, United States

Tae-Sung Koo, Chungnam National University, Korea

Hui Tang, University of Toronto, Canada

Pamela Loughran, University of Guelph, Canada

Jean-Francois Tetu, Tebu-Bio, France

Jiyuan Ma, PTC Therapeutics, Inc., United States

Sarah Woody, University of Kansas, United States

Carol Marchant, Lhasa Limited, United Kingdom

Jiekun Xuan, National Center For Toxicological Research, USFDA, United States

Submit an abstract for the 5th Asia Pacific Regional ISSX Meeting in Tianjin, China May 9–12, 2014. Visit to submit an abstract. Abstract submissions for the general poster presentations and Poster Awards Competition are due by Friday, January 31, 2014.

ISSX 2014 Membership Support ISSX! Renew with ISSX for the 2014 Membership term!

Join the  Japanese  Society  for  the  Study  of  Xenobiotics  (JSSX)     and  the  International  Society  for  the  Study  of  Xenobiotics  (ISSX)     at  a  joint  scientific  meeting  October  19  –  23,  2014  in     San  Francisco,  California,  USA.      

Meeting Organizing  Committee  

Tetsuya  Terasaki,  PhD  (Meeting  Co-­‐Chair)   Tohoku  University     Eric  Johnson,  PhD  (Meeting  Co-­‐Chair)   The  Scripps  Research  Institute     Toshio  Teramura,  PhD   Astellas  Pharma,  Inc.     Kan  Chiba,  PhD   Chiba  University     Natilie  Hosea,  PhD   Pfizer  Inc.     Takashi  Izumi,  PhD   Daiichi  Sankyo  Co.,  Ltd.     Mikihisa  Takano,  PhD   Hiroshima  University     Ikumi  Tamai,  PhD   Kanazawa  University     Bill  Smith,  PhD   Pfizer  Inc.,  La  Jolla  Labs     Frank  Gonzalez,  PhD   National  Cancer  Institute     R.  Scott  Obach,  PhD   Pfizer  Inc.     Hiroshi  Yamazaki,  PhD   Showa  Pharmaceutical  University     Hiroshi  Suzuki,  PhD   The  University  of  Tokyo  Hospital     Paul  Ortiz  de  Montellano,  PhD   University  of  California,  San  Francisco     Peter  W.  Swaan,  PhD   University  of  Maryland     Xiao-­‐bo  Zhong,  PhD   University  of  Connecticut  School  of  Pharmacy

Features of  this  Meeting    

This meeting  will  feature  short  courses,  keynote  lectures   delivered  by  leading  researchers,  parallel  sessions,   poster  sessions,  awards  presentations,  a  vendor   exhibition,  and  multiple  opportunities  for  attendees     to  enjoy  social  interaction  with  friends,  acquaintances,   and  other  meeting  attendees.    

Meeting Venue    

With its  prime  location  near  Nob  Hill  and  Chinatown,  

the Hilton  San  Francisco  Union  Square  provides   easy  access  to  all  that  San  Francisco  has  to  offer.         San  Francisco  is  renowned  for  its  steep  rolling  hills,   eclectic  architecture,  and  landmarks  including  the   Golden  Gate  Bridge,  cable  cars,  the  famous  Lombard   Street,  Alcatraz  and  much  more.    

Its international  airport  is  a  major  gateway  to  Asia  with   direct  flights  from  more  than  40  countries  daily.        



Save the  Date  and  Make  Plans  to  Join  us  in  San  Francisco  October  19  –  23,  2014  

President’s Message Continued from page 1

Glasgow meeting will be co-chaired by Roland Wolf (University of Dundee) and Ann Daly (Newcastle University), and finally the Providence meeting chair will be Jashvant Unadkat (University of Washington). We have great chairs and meeting organizing committees to develop terrific programs for these upcoming meetings. I look forward to seeing these conferences take shape and attending them myself in a few years. Another passion during my term has been to support the international mission of ISSX. During my terms as Secretary, President-Elect, and President I have been a strong supporter of the growth of ISSX in the AsiaPacific region. A key focus was developing sustained relations with the leaders of our affiliate organization, the Chinese Society for the Study of Xenobiotics (CSSX). I helped organize and participated in workshops and conferences with CSSX in Shanghai, Guangzhou, Xi’an, Tianjin, Nanjing, and Kaifeng from 2010-2013. I am proud that I was able to contribute to the vision of ISSX PastPresident, Yuichi Sugiyama, to grow the activity of ISSX in China and the AP region. Additionally, we recently started work in India on a small scale to build our presence in a country where there are many scientists in universities and companies interested in xenobiotic research. In closing my final ISSX Newsletter contribution, I want to say that it has been a privilege to serve the ISSX membership during my term. I will cherish the memories of all the new friendships formed, exciting events, and even the occasional stressful situations I encountered during my term. I look forward to the future meetings of ISSX and I hope we can meet to discuss interesting scientific developments in the fields of xenobiotic research.


/ISSX Newsletter / Issue 4 2013

All the best, Bill J. Smith ISSX President

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Submit an Abstract for the 19th North American ISSX and 29th JSSX Meeting in San Francisco, California October 19–23, 2014 The Call for Abstracts opens Monday, January 6! Present your work and network with fellow researchers. This meeting also features a predoctoral and postdoctoral poster awards competition as well as opportunities for poster authors to give brief podium presentations.

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Issue 1, 2014

February 14, 2014

March 2014

Issue 2, 2014

May 16, 2014

June 2014

Pre-Meeting Issue

August 15, 2014

September 2014

Issue 4, 2014

November 14, 2014

December 2014


Subject to change

Editor Dr. Allen Cato, III Cato Research, LTD 6480 Weathers Place, Suite 104 San Diego, California 92121 USA Telephone: +1-858-452-7271 Fax: +1-858-452-7784 E-mail:

Advertise with ISSX The quarterly ISSX Newsletter is an online publication featuring Society updates, scientific articles of interest, book reviews, summaries of ISSX meeting proceedings, and more. This publication is designed to update the ISSX membership on the activities and events of the organization and to provide an information forum. Not only is the ISSX Newsletter promoted directly to all ISSX Members, but, as of 2012, it is also available to anyone who visits the ISSX Web site. Visit today!

Issue 4, 2013

/ISSX Newsletter / 11

ISSX Newsletter Issue 4, 2013  

ISSX News, President's Message, Book Review, Meetings Updates, New Members Listing, and more.

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