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Poster Abstract 1 2 Title: PATTERN OF HAEMOGLOBINOPATHIES WITH CAPILLARY ELECTROPHORESIS - A SINGLE CENTRE STUDY AT ICDDR, B Abstract Category: Epidemiology and Prevention Authors: Hafizur Rahman, Raisa Akther, Zahidul Islam, Mazed Ali, Bikash Chandra Chanda Corresponding/Presenting Author: Hafizur Rahman Affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) Email: hafizur@icddrb.org Address: 68, Shahid Tajuddin Ahmed Sharani Mohakhali Dhaka-1212 Bangladesh ABSTRACT: Background Haemoglobinopathies represent significant frequencies across almost all ethnic groups in Southeast Asia including Bangladesh posing a major genetic and public health problem. In Bangladesh; we have very limited data about the pattern and carrier frequency of haemoglobinopathies. Thus, the present study was thus undertaken to find out the pattern and spectrum of haemoglobinopathies in Dhaka city, the capital of Bangladesh. Method Retrospective analysis of 978 samples were carried out for haemoglobinopathies screening from January 2007 to May 2015 which has been submitted at diagnostic labs of icddr,b. Capillary electrophoresis (CE) was used as a first line of investigation for all patients who had a clinical or familial suspicion of haemoglobinopathies. Results and conclusion There were 978 abnormal chromatograms detected of 3640 population being studied. Of these, males were 457 (46.7%) and females were 521 (53.3%). Among these, 430 (43.96%) were HbE trait, 364 (37.21%) β-thalassemia trait, 91 (9.3%) HbE/β-thalassaemia, 68 (6.95%) HbE disease, 8 (0.81%) HbS trait, 6 (0.61%) Hemoglobin D Punjab and 3 (0.31%) cases were homozygous β-thalassaemia. Single case of heterozugous state with Hb Hope, Hb J-Kaohsiung, Hb Lepore and Hb C were also found. Overall, heterozygous (or carrier) states were 816 (83.4%), and homozygous or double heterozygous (or disease) state were 162 (16.6%) respectively. Since the study populations were mostly referred cases, where the diagnostic facility is not much available, this may not be true prevalence of haemoglobinopathies; further work is needed to find out the pattern of haemoglobinopathies, in particular high-frequency populations and to provide solid evidence of health burden posed by the haemoglobin disorders in Bangladesh and other developing countries in Southeast Asia.
2ND PAN-ASIAN CONFERENCE ON HAEMOGLOBINOPATHIES