Aging Matters Issue 4 2014

No 4, 2014

US $8.00/ EU €6.00/ GB £5.00 where sold

The

HYPOTHYROID Epidemic

By Richard Stanley Wilkinson, M.D.

PLUS: Dr. Lippman talks about free radicals and the 4-lines of defense The importance of enzymes Dr Ward Dean answers your questions ia

s

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Welcome

Index

The story of the thyroid is a big one; it’s a gland that has so many functions and it is of paramount importance to our health. Yet, Dr. Broda Barnes estimated that 40% of the adult population are thyroid deficient!

Welcome -Phil says thanks for finding the time 3 The hypothyroid epidemic -Dr Wilkinson describes what to do 4 Free radicals and their scavengers -Dr Lippman elaborates on his research 11 The importance of enzymes -How earthworms are leading the way! 15 Dr Ward Dean Q&A -Dr Dean answers your questions 19 Featured products -Best sellers and new items 23 Testimonials & Explanations -Nice people, nice comments 32 Complete product A-Z list and prices -Find everything in-stock here 32 Condition cross-reference list -Find the right product for you 45 Contact details -Get in touch with IAS today 50

So we are delighted to have Dr. Rick Wilkinson; (a world thyroid expert and pupil of Dr. Barnes) who describes the issues and how to go about correcting them. If you regularly have cold hands and feet, infections and lethargy then your thyroid may be to blame.

Recently, I managed to catch up with Dr. Richard Lippman whilst he was on his way from Sweden to Scotland. We discussed free radicals and their scavengers; you will discover in his interview that he was nominated for the Nobel Prize in Medicine for measuring free radicals in-vivo and discovering the body’s natural four lines of defence.

Furthermore, we have the role of enzymes and how the earthworm enzyme lumbrokinase is leading the way to blood flow health.

Please tell us how we’re doing for you; we welcome your comments and suggestions.

Phil Micans, MS, PharmB Editor, Aging Matters™ Magazine Ward Dean Ward Dean, M.D., Medical Advisor

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Declaration: The IAS Aging Matters™ magazine is intended for IAS private club members and focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental and internal changes consisting of the diseases and disorders such as cancer, arthritis and senile dementias etc. However, the main focus is upon the prevention of such aging diseases and disorders for the ‘healthy-aging’ individual.

Copyright 2014: All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork or advertising materials while in transmission or with the publisher or their agents.

Disclaimer: All educational information is offered under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS or the magazine. All prices shown are in US Dollars and are for reference purposes only and they do not include taxes (where applicable), nor do they include shipping & handling fees. Prices, conditions and terms are subject to change without notice.

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might feel tired and weak. And they might hurt. If your brain is deficient in thyroid hormones, it might seem as though your brain isn’t working. As some of my patients describe it, “My brain feels like it’s in a fog”. It’s hard to think. Your joints might swell and hurt if thyroid hormones are not getting into the cells where the hormones can do their work. Your ovaries may not work properly and you can’t get pregnant (this is a fairly common issue, often undiagnosable using only conventional testing). Your intestines might not have the energy to function and you experience constipation--or paradoxically, you might have diarrhea. It’s well known that low thyroid causes hardening of the arteries (atherosclerosis) which leads to heart attacks and strokes. We’ll explore this further later in the article.

In addition to the above, low thyroid is a common cause of many symptoms including high cholesterol levels, premenstrual syndrome, post-partum (after having a baby) depression, weight gain, depression, cold extremities, chronic fatigue syndrome, fibromyalgia, high levels of homocysteine (a natural material in the blood, but large amounts can be dangerous), high blood pressure, and diabetes.

Do you happen to know anyone with any of those problems?

Of course, we all do. And there is a crowd of people out there with these types of problems.

The epidemic of low thyroid diseases

By Rick Wilkinson, M.D. The function of every cell in the body depends on the presence of an adequate amount of thyroid hormones in order to do the work it is supposed to do. Brain cells need thyroid hormones to think.

Muscle cells need thyroid hormones to move.

Therefore, what happens when a person’s thyroid is not working as well as it should? When inadequate amounts of thyroid hormones are able to enter into each cell to perform its normal work, what does a person experience?

There is this magnificent little molecule called T3 (one of several thyroid hormones), that is absolutely necessary for the cells of the body to produce energy. You eat food and you breathe in oxygen--but if you don’t have adequate T3, the food and the oxygen won’t be able to do much. T3 is involved in the process of mating food and oxygen (what you eat and what you breathe) in order to make energy for muscles, nerves, and other cells so that they are able to do what they are supposed to do.

Imagine that your muscles don’t have enough thyroid hormone. What are you going to experience? The muscles 4

Can you trust the accuracy of the routine thyroid tests?

A low thyroid status can cause the problems listed above. But many people with those problems have been told that their thyroid is normal. Is it always true that their thyroid is, in fact, “normal?”

A question we should ask is this: Might a lot of those symptoms or diseases be caused primarily or in part by low thyroid status but missed due to conventional testing and diagnostic methods? What is particularly interesting is that many of these problems will tend to improve or disappear when there is appropriate thyroid treatment.

Because there are so many people with fatigue, menstrual disorders, high cholesterol, depression, diabetes and such that are able to enjoy a much higher level of function with appropriately prescribed thyroid therapy, many doctors are recognizing that we are facing an epidemic of hypothyroidism (low thyroid status) that is not adequately diagnosed by using only blood tests during a medical workup.

These physicians are beginning to realize that the currently popular method of testing for thyroid status is inadequate, and often falsely leads doctors to believe that their patients have sufficient thyroid hormones when, in fact, they do not.

When we understand 1) what the thyroid hormones do, and 2) what it looks like when the thyroid system is not working properly, we are better able to accurately determine thyroid status than by looking only at a laboratory test or two.

We’ll try to explain this so that it isn’t too confusing. But first let’s consider the potential benefits of having a thyroid status that is slightly on the higher side of normal rather than slightly on the lower side of midrange.

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Was Mona Lisa hyperthyroid?

important lifestyle issues.

Allow me to quote a Nobel Prize winner, Harvard cardiologist Dr. Bernard Lown, addressing this issue in a tangential way.

Dr. Lown deeply admired his chief mentor, Dr. Samuel Levine, and wrote about him in a wonderful book, The Art of Healing.

His affection for this brilliant doctor brightens the paragraphs and pages in which he eulogizes this wise gentleman.

But if you are treating your body well, feeding it well, and you’re still feeling poorly, thyroid legitimately might be an important factor in your getting well.

After Dr. Levine retired, he began seeing Dr. Lown as his personal cardiologist. Through the roles of student and doctor, Dr. Lown learned a great deal about Dr. Levine. Perhaps the most interesting observation regarding Dr. Levine, in the current context, is the following: “Dr. Levine was impressed with the brightness and quickness of hyperthyroid (too much thyroid) patients. He admired them intensely, and believed that the condition protected them against coronary artery disease. I later learned, when he became my patient, that he had taken three grains of thyroid daily (that is, Armour® thyroid or equivalent) for more than thirty years. He maintained that those with increased thyroid function had bright, sparkling eyes and appeared to be interesting people, because personality is conveyed largely through the eyes. Levine suggested that the universal fascination with the Mona Lisa stems from her being hyperthyroid. He insisted that a slight stare makes viewers believe that she is focusing on them and is the basis for the attention this painting has received over the centuries.”

Dr. Levine is here talking about people with a slight excess of thyroid by current standards, not severely hyperthyroid people. Because he would rather be slightly hyperthyroid than slightly hypothyroid (low thyroid), Dr. Levine took a rather generous dose of natural, desiccated thyroid for many years.

Whether the good doctor was correct in his appraisal of Mona Lisa, we’ll never know. But in regard to other issues, Dr. Levine is increasingly being shown to be correct. Namely, the benefit of thyroid for the cardiovascular system, the use of natural, desiccated thyroid, and the value of dosing a patient toward the upper end of the acceptable range rather the low end.

It may help to know what is meant by natural, desiccated thyroid. In the marketplace, it is often known as Armour® thyroid, Nature® throid or ERFA®.

Poor lifestyle and hypothyroid symptoms In light of this information, how do you take action if you think that you might have low thyroid function? A couple of cautions you should consider before concluding that you must have hypothyroidism.

First, diet is terribly important. Putting on weight while drinking Frappuccino’s in the morning and a few pints in the evening is not likely a thyroid problem.

Second, if you’re tired but you’re working three jobs, sleeping 4-5 hours each night, and getting no exercise, I doubt that your fatigue is primarily a thyroid issue.

Lifestyle choices are hugely important for feeling good and having plenty of energy. If you really want to feel good, pay attention to your food choices, sleep habits, exercise and other

The TSH test: measuring the voice of the pituitary This is where some of the challenge for the consumer (you) comes in. If you’re concerned, legitimately, about some of these thyroid related issues, how do you know if you need thyroid?

Without getting very technical, there are a few basic definitions that you need to have a handle on in order to understand what your lab work means and how to discuss your situation with your doctor.

The most frequent way that doctors evaluate thyroid status is to have blood drawn in which the thyroid stimulating hormone (TSH) is checked. You especially need to understand the significance of the TSH. The pituitary is a small gland situated in the forward part of the head a bit behind and between the back ends of the eyes.

It’s the boss of the thyroid. The pituitary tells the thyroid what to do. The pituitary continuously samples the blood for one of the thyroid hormones and if the thyroid is not doing its job, the pituitary says, “Get to work.” At first it suggests the need for improved efficiency on the job with a very soft voice (TSH is not elevated). But if there is an inadequate response on the part of the thyroid, the pituitary raises its voice bit by bit until it can be shouting and even screaming at the thyroid to get off its duff and start producing thyroid hormones, (elevated TSH).

The current definition of low thyroid primarily has to do with how loudly the pituitary is talking to the thyroid. As long as the pituitary’s voice is not too high, it is assumed that the thyroid is doing its job. After all, the pituitary, which monitors and bosses the thyroid, is happy, or so the current medical thinking goes. If the pituitary is raising its voice (elevated TSH), then the thyroid must not be producing adequate thyroid hormones. A person with a pituitary having to shout (elevated TSH) at the thyroid, is by current popular definition hypothyroid.

The TSH is the measure of the how loudly the pituitary is speaking or shouting. The conventional definition for low thyroid function (hypothyroidism) is a TSH over about 5.00.

So if you go to the doctor and your TSH is 5.20 you might be told that your thyroid is a bit low and you need to begin thyroid therapy. On the other hand, your TSH might be 4.80.

In which case your doctor might say your thyroid is normal and you don’t need any thyroid.

Typically unrecognized limitations in using the TSH test There are several problems with this definition. First and foremost has to do with the clinical picture of what is happening with you. Do you have any signs or symptoms of low thyroid? If you do have symptoms/signs that are suspicious for low thyroid, then a TSH of 4.80 or even a lot lower might be consistent with low thyroid.

As one example, suppose that the pituitary is “hoarse” or has “laryngitis”. It can’t raise its voice even if it wants to. It might

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be trying to scream but only getting out a gentle whisper.

In which case, a low thyroid would be consistent with a low TSH (contrary to the usual picture). So we either have to test for “pituitary laryngitis” (which can be done) or pay close attention to the signs and symptoms of the person.

Often a woman will have a damaged pituitary following childbirth in which it becomes unable to raise its voice (Sheehan’s syndrome). These women are often misdiagnosed as depressed or malingerers when, in reality, they are hypothyroid with low TSH. Treat them with thyroid as they should be treated and all becomes well. This is one of the challenges of an overly-simplistic diagnostic approach.

Another reason that total reliance on TSH levels is inappropriate is that TSH levels can vary substantially during the day. There can easily be a 200% or more variance during the day in a given individual. On the desk in front of me are the 24-hour measurements of two patients where the TSH was drawn every few minutes. With one patient the 24-hour low was about 0.30 and the high was about 2.00. The other showed a low of about 1.00 and a high during the 24 hours of approximately 5.00.

A TSH of 1.00 is considered good, but a TSH of 5.00 would often be considered high, indicating low thyroid status. So which is the TSH to use?

Another legitimate and argued question is: At what level is the TSH too high? As mentioned above, most labs use a number in the vicinity of 5.00. The American Society of Clinical Endocrinologists suggests that when treating low thyroid problems the TSH should be kept below 3.00. If a TSH above 3.00 is not best for a patient being treated, it’s reasonable to ask if a TSH of 5.00 might not be too high for an untreated person.

The experts in designing tests to evaluate human health are members of the National Academy of Clinical Biochemistry.

They have recently noted the following: • Over 95% of healthy people with optimal thyroid function have a TSH that is less than 2.50.

• Patients with a TSH above 2.50 may be in the early stages of thyroid failure.

• When treating a patient, the TSH optimally should not be above 2.00.

It is also important to measure the actual amount of thyroid hormones present in the blood. There are two main hormones.

One is called T4, as it is the thyroid hormone with four iodine atoms attached to it. The other is T3, because it has three iodine atoms attached. T3 is some three to ten times as active as T4. If T4 or T3 are low, (or even low end of normal range) the thyroid system may not be functioning optimally.

One other thing; if you have an inflammation of the thyroid gland (thyroiditis or Hashimoto’s thyroiditis) you can have normal levels of TSH, T4 and T3, but the whole thyroid system might not be working right. Often we find that people with thyroiditis feel much better when treated with thyroid hormones.

Thus we see that measuring only TSH levels is inadequate 6

to optimally evaluate the thyroid status. We believe that a thorough initial evaluation should include TSH, thyroid antibodies (to check for thyroiditis), free T3 and free T4 (the active or available forms of T3 and T4) and possibly reverse T3.

A better way to diagnose low thyroid Ultimately, the most important factor in making a diagnosis is the knowledge and awareness of the physician. A physician aware of the importance of optimal thyroid function is going to consider at least the following factors: 1. Your blood work.

2. Your history including important symptoms you are experiencing.

3. An endocrinologically oriented physical examination.

4. Your temperatures (thyroid maintains body heat).

For a variety of reasons that we will not discuss in any detail here, every blood test may be perfectly normal and a person might still need thyroid hormone supplementation. That’s the reason for the four-point approach to evaluation.

If we return to the thinking of the previously-referenced Dr. Samuel Levine, you’ll appreciate what I mean. Dr. Lown says the following about his mentor: “He recognized… that ‘medicine is the science of uncertainty, the art of probability.’ He believed that the bulk of relevant information could be obtained from a properly gathered history and meticulously executed physical examination. He taught that a battery of tests must not replace a mind willing to think… “He hinted that frequent reliance on a so-called workup, engaging the heavy medical artillery of the day, such as X-ray or cardiac fluoroscopy, electrocardiography, phonocardiography, blood work and urine analysis, is testimony to a lack of clinical skill…”

My own mentor on the subject of thyroid evaluation and treatment was Broda Barnes, M.D., Ph.D. Dr. Barnes was direct in his thoughts regarding the evaluation and treatment of patients. He said, with great vigor; “Always treat the patient, not numbers on paper.” By this he meant that many doctors are too busy to listen to the patient and to do the requisite exam, or they were ignorant of what the signs and symptoms of low thyroid truly were. Thus, hypothyroidism was, to them, only what the numbers on paper would report. If a patient’s TSH was 4.80, in these doctors’ minds the patient was normal.

If the TSH was 5.20, the patient was hypothyroid. For Dr. Barnes, that was not being a good physician.

A brief review to clarify 1. TSH is the generally accepted method of diagnosing thyroid status. A high TSH is thought to always indicate low thyroid status. A low TSH is usually interpreted as too much thyroid.

And a normal TSH is considered indicative of normal thyroid function.

2. There is now a large body of data that shows us that this interpretation of TSH is only legitimate in some cases.

People who are depressed may have standard laboratory tests all showing normal. But they are often shown to be

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hypothyroid when more advanced testing is done. People with inflammatory diseases such as some forms of arthritis will often have normal standard lab reports--but when more accurate testing is done they are shown to be low in thyroid. Ditto, when one is dieting (calorie restriction). Ditto with chronic fatigue syndrome. Ditto with diabetes and fibromyalgia and obesity and others.

3. The best way to diagnose thyroid status is to use a combination of: a. A variety of blood tests, not just TSH, or TSH and free T4. b. A thorough history taken by someone who understands nuances of hypothyroid manifestations. c. An endocrinologically oriented physical exam. d. Basal body temperatures or other methods of evaluating metabolic status.

Dr. Ord in London A correct diagnosis of thyroid status may be critically important. Let’s use the example of atherosclerotic heart disease (heart attacks).

In the mid-1870s, virtually nothing was known about the function of the thyroid. One of the classic presentations in the history of thyroid research was given by Dr. William Ord. He described a patient who had been a healthy and industrious woman at the age of 49. She gradually became cold, experiencing shivering spells. Her mental faculties and memory decreased. Her movements became slow and awkward--it required two hours for her to dress herself. She would fall asleep unless she was moving. She died at age 60.

On autopsy it was discovered that her thyroid gland was entirely destroyed by fibrous tissue. The pathologist described the vascular system like this: “…the arteries were everywhere thickened, the larger ones atheromatous.”

In other words, she had extensive atherosclerotic (hardening of the arteries) disease of all larger arteries. Dr. Ord was convinced that there was a connection between the destruction of the thyroid gland and the symptoms she had, including the damage to the arteries. A commission was chartered to explore the function of the thyroid gland. Over the following years, a reasonably clear picture of the role of the thyroid was obtained.

What is clear and generally accepted is that low thyroid function causes or contributes to hardening of the arteries.

Professor Billroth of Vienna This gentleman is one of the most famous surgeons of history. Very large goiters (enlarged thyroid glands) used to be relatively common. Cosmetically, they were disturbing.

The good professor developed a safe and effective method of removing thyroid glands. However, with no thyroid gland remaining, the people became severely hypothyroid and would die of myxedema, a technical term for the swelling associated with very low thyroid function.

An Austrian law mandated that everyone dying in hospital be autopsied. It was discovered that all of these patients dying of low thyroid because their thyroids had been removed had

generalized, severe hardening of the arteries throughout the body.

A student of Billroth, von Eilsberg, did further research demonstrating that the removal of the thyroid gland from sheep and goats led to systemic atherosclerosis.

Professors Pick and Pineless, also of Vienna, removed the thyroid glands of sheep and goats, but provided the animals with thyroid replacement similar to Armour® thyroid. These animals did not develop atherosclerosis.

American Research Dr. Hurxthal of the Lahey Clinic in Boston reported on observations in their clinic. They would remove the thyroid gland of patients who were hyperthyroid (too much thyroid).

Dr. Hurxthal noted that these patients would often have cholesterol levels that were quite low prior to the surgery. But after the surgery, if too much thyroid tissue were removed rendering the patient hypothyroid, they would often develop high levels of cholesterol.

The relationship between thyroid status and high cholesterol levels was so significant that Hurxthal suggested that serum cholesterol might be considered as a diagnostic measure for thyroid function. He even suggested that elevated cholesterol might be an indication for thyroid therapy if another cause for the hypercholesterolemia could not be found.

Professor William Kountz, Washington University of St Louis, published in 1951 Thyroid Function and Its Possible role in Vascular Degeneration. He reports on a study of patients with low body temperatures and many with elevated cholesterol.

The first group was businessmen with an average age of 55.

This group had little evidence of hardening of the arteries and the men were patients in his private practice. A second group were outpatients at the University Clinic. These men averaged age 61. Many already had evidence of some hardening of the arteries.

Each group was divided into two. One of the subgroups received thyroid treatment. The other subgroup did not receive thyroid. All groups were followed for five years and monitored for heart attacks and strokes.

• Group one: There were no deaths in those treated with thyroid. In the untreated group, 15% had a fatal heart attack or stroke.

• Group two: There was 3% mortality in the treated group and 19% mortality in the untreated group. Over six times as many men died in the untreated group.

Dr. Barnes went to Graz, Austria every year for fifteen years and spent at least one month studying the autopsy records accumulated over some 200 years. As mentioned above, every hospital death required autopsy.

The conclusion of a huge amount of work and research is this: Low thyroid people are subject to increased risk of infection and poorer ability to fight the infection. Prior to the advent of antibiotics these people would routinely die of infections prior to dying of heart attacks. The records show that those dying of infections had extensive hardening of the arteries. After 7

antibiotics became available, these people would be treated allowing them to live long enough for heart attacks to kill them.

‘Normal’ vs. optimal Recent research indicates that just having normal thyroid function based on TSH levels is not necessarily optimal. The increased risk of atherosclerosis in borderline hypothyroidism extends into the normal range. In other words, having a high normal TSH (borderline low function) increases your risk of hardening of the arteries. One study suggests that the lowest possible TSH within the normal range (i.e. around 0.4) is the best way to reduce risk of cardiovascular disease. “Normal” is not the same thing as optimal as this study demonstrates.

In the field of antiaging or integrative medicine, our goal is to achieve the optimal range, not just the ‘normal’. Studies like this confirm our setting of higher goals.

Thyroid and cholesterol People with subclinical hypothyroidism, (a technical term for people with no dramatic symptoms of low thyroid function and an elevated TSH) often have elevated cholesterol levels.

When treated with thyroid replacement hormones, there is a significant decrease in both total cholesterol and in LDL (the so-called ‘bad’ cholesterol).

The higher your T3 levels are, the lower your cholesterol levels are likely to be.

Another study looked at 35 male patients with severe atherosclerosis. They monitored these men for two years and again evaluated the amount of hardening of the arteries. In 14 there was no progression of the disease. 21 had significant progression. They then asked what was most significant in apparently preventing progression. One of the two most important factors was the T3 level, (the active form of the thyroid hormone included in Armour® thyroid but not in Synthroid® or its equivalents).

Articles like these begin to delve into the issue of which is the best way of treating low thyroid function. We’ll address this a little later. But with information such as this, many of us who work daily in this field question the notion of treating patients only with T4-containing preparations such as Synthroid® and Levoxyl®. This article shows that higher levels of T3 are at least suggestive evidence that a combination of T4 and T3 might be preferable to T3 only.

There are a large number of articles dealing with the issue of atherosclerosis and thyroid function. The challenge for a writer is choosing from so many that demonstrate the same principle: adequate treatment with thyroid hormones is often protective against hardening of the arteries and thus heart attacks.

Other benefits of appropriate thyroid replacement Homocysteine is a known risk factor for heart attacks, strokes and peripheral artery disease like claudication (pain in legs with walking due to atherosclerosis). It is a toxic metabolite (breakdown product) of the amino acid methionine. Elevated homocysteine levels are also associated with increased risk of bone fracture, dementia and attention deficit.

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People with low thyroid function tend to have high levels of homocysteine. People with high thyroid levels have low homocysteine levels. Therefore, treating people with high homocysteine levels and indications of hypothyroidism with appropriate thyroid therapy might benefit the high levels of homocysteine. This might reduce the risk of heart attacks, strokes and bone fractures.

Fatigue, sadness, irritability, anger, sleepiness, sense of being chilly or hot and a variety of other symptoms are rather common in today’s world. These are all possible signs of hypothyroidism.

A study published in 1999 looked at a group of patients who had previously been diagnosed with hypothyroidism. These patients had all been treated with T4 only (i.e. Synthroid® or an equivalent). However, their symptoms (as listed in the previous paragraph) had not improved.

The study reduced the amount of T4 given to each patient and added in a roughly biological equivalent of T3. These patients were now receiving a combination of T3 and T4 (similar to what one receives by using Armour® thyroid).

The conclusion of the study was that nobody did better on T4 alone. Most of the patients did better on the combination of T4 and T3. “It seems clear that treatment with thyroxine (T4) plus triiodothyronine (T3) improved the quality of life for most patients.”

The best treatment for hypothyroidism The most common therapy for hypothyroidism is T4 only, or a medication like Synthroid®, Levoxyl® or the generic levothyroxine. We have quoted various articles which suggest that the combination of T3 with T4 might be beneficial for a number of reasons. Dr. Levine, mentioned in the first part of this article, routinely took a combination of T3 and T4, the combination included in desiccated thyroid.

Dr. Barnes, my mentor on thyroid treatment, tested a variety of thyroid preparations. His conclusion was that most patients do best using Armour® thyroid.

Most important to me as a treating physician is: How does my patient feel with the treatment I’m providing? Does s/he feel better as a result of taking the thyroid hormone?

In the Bunevicius study reviewed above, patients taking T3 and T4 clearly felt much better than when they took T4 only.

My experience in treating patients like this for some 25 years is that most of them feel better taking the T3 and T4 combination than if they take the T4 alone. I’m not dogmatic about the use of the combination as I’m interested in the well-being of the patient. There are a few (very few) that actually feel better taking the T4 alone. For them I gladly prescribe Synthroid® or an equivalent.

Most patients, however, feel best taking the combination of T3 and T4. I routinely prescribe Armour® thyroid, which is desiccated (dried) thyroid tissue with a carefully regulated amount of T3 and T4 included in it.

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How I transfer my patients from T4 only therapy to desiccated thyroid One must first understand that there is not an exact equivalence between T4 preparations and Armour® thyroid.

When a person takes T4 medications, the amount is given in micrograms. Synthroid® 50 means 50 micrograms of Synthroid®.

Armour® thyroid is given in milligrams and indicates the amount of desiccated (dried) thyroid tissue being used.

The amount of T4 and T3 in the thyroid tissue is carefully regulated. One grain of Armour® thyroid contains 38 micrograms of T4 and 9 micrograms of T3. (Of interest, Armour® thyroid also contains T2 which has an increasing amount of fascinating data showing that it may also be an important factor in overall thyroid health. Synthroid®, of course, contains no T2.)

T3 is typically considered to be 4 times as potent as T4. One grain of Armour® has 38 micrograms of T4 plus 9 micrograms of T3, which is considered to be equal to approximately (4x9=36) 36 micrograms of T4. One grain of Armour® has the equivalence of 74 (38 mcg from T4 + 36 mcg equivalence from T3) micrograms of T4.

for advice on dosing. We then will decrease the prescription appropriately. In practice, this seldom happens.

Conclusion Optimal supplementation with natural forms of thyroid hormones has a strong healing benefit for those whose native thyroid status is less than optimal. When treatment is adequate it can help to lower cholesterol, improve depression and prevent advancement of atherosclerosis. It can also help to lower blood pressure and generally help people to feel better.

There are many other benefits we are unable to discuss in a brief article.

The diagnosis of low thyroid function is based on a combination of the symptoms a person is experiencing, a physical examination, body temperatures and blood work. Most people will feel best if thyroid replacement is done using desiccated thyroid, which includes a combination of T3 and T4.

The information presented in this article should assist you in being able to intelligently discuss thyroid replacement issues with your physician.

References

When I make the switch from Synthroid® to Armour® equivalents, I calculate approximately what the appropriate conversion would be. If a person is taking 75 micrograms of Synthroid®, I would consider changing to Armour® 60 mg based on the above calculations. If a person is taking 150 micrograms of Synthroid®, 120 milligrams of Armour® might be a good dose to change to.

Lown, B, The lost art of healing, Houghton Mifflin Company, Boston, 1996, p 9

I usually do not have them stop Synthroid® one day and start full dose Armour® the next day. I’ve found that I have fewer problems in making the conversion if a person takes half their Synthroid® dose and half their projected Armour® dose for 7-10 days. Then I have them stop the Synthroid® and take the full dose of Armour®.

Lown, p 4

Synthroid® equivalents are usually scored so they are easily broken in half. Armour® is not quite so easily divided, but is not too difficult with the use of a sharp knife. [Ed. – natural thyroids are available in a wide range of doses, so at least initially the patient can use a different dose before reaching their regular plateau].

The transitions are not always so clear cut. What to do when a person is taking 100 micrograms of Synthroid? I will usually transition to Armour® 90 milligrams, especially if I think that the person is running a bit low. Effectively, 90 milligrams of Armour® is a higher dose than 100 micrograms of Synthroid®.

When making the change, I always let my patients know what to expect if it turns out they are getting too much thyroid.

Typical symptoms of too much thyroid will be: 1. Rapid heart rate.

Greenspan Sl et al, Pulsatile secretion of TSH in man. J Clin Endocrinol Metabol 1986;63:664 Baskin HJ, American association of clinical endocrinologists medical guidelines for clinical practice for the evaluation and treatment hyperthyroidism and hypothyroidism, Endocrine Practice Vol 8 No.6 Nov/Dec 2002 NACB, Laboratory Support for the diagnosis and monitoring of thyroid diseases, available at http://www.nacb.org Personal discussion with Dr Barnes See for example Cappola AR & Ladenson PW, Hypothyroidism and Atherosclerosis, J Clin Endocrinol Metab, June 2003, 88(6):2438-2444 or for an older, more reader friendly perspective on the subject see Barnes and Barnes, Solved: The Riddle of Heart Attacks, Robinson Press, Fort Collins, 1976 For more information on this viewpoint, see Mason RL, Hunt HM, and Hurxthal L NEJM 203, 1273-1278, 1930, and see Barnes and Barnes Bakker SJL et al, The relationship between thyrotropin (TSH) and low density lipoprotein cholesterol, J Clin Endocrinol Metab, 86: 1206-1211, 2001 Meier C et al, Lipid-lowering effect of T4 in hypothyroidism, J Clin Endocrinol Metab, 86(10): 4860-4866, 2001 Elder J et al, Ann Clin Biochem, 27:110-113, 1990 Barth JD et al, Progression and regression of human coronary atherosclerosis, Atherosclerosis, 68(1-2): 51-58, Nov 1987 Hussein WI et al, Normalization of hyperhomocysteinemia with L-thyroxine in hypothyroidism, Annals of Internal Medicine, 131(5): 348-351, Sept 1999 Sato Y et al, Effect of folate and mecobalamin on hip fractures in patients with stroke, JAMA, 293:1082-1088, 2005 Diekman MJ et al, Determinants of changes in plasma homocysteine in hyperthyroidism and hypothyroidism, Clin Endocrinol (Oxf), 54(2): 197-204, Feb 2001 There are other papers which also demonstrate improved homocysteine levels with thyroid treatment including Hussein et al above.

Bunevicius R et al, Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism, NEJM, 340:424-429, Feb 1999

2. Palpitations.

3. Feeling hyper, something similar to drinking too much coffee.

If one of my patients begins having these symptoms, I advise them to stop the thyroid for a day or two and call my office www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

9

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Dr Lippman at home in Hawaii

Interview with Richard Lippman PhD about free radicals, aging and ACF228® Phil Micans, the Editor of Aging Matters magazine interviews Dr Richard Lippman on 5/5/2014 - (herein referred to as PM and RL respectively).

PM: “Dr. Lippman it’s a great pleasure to be in your company again and thank you for coming to England.”

RL: “Thank you Phil, I’m glad to be here.”

PM: “My pleasure. Of course you’ve contributed many great articles and indeed videos to the IAS website already, but I was hoping in this interview we’re doing today to ask you firstly- how did you become a world expert in free radicals?”

RL: “During the late 1970s I was connected with a group at the Royal Institute of Technology in Stockholm, Sweden- their leading technical institute. There, I studied physical chemistry and physics. In the physics laboratory we were generating free radicals from a cobalt 60 cannon

and studying the effects and damages of the various free radicals to living tissues, as well as the downstream by-products; as a consequence, I got together with a group in northern Sweden under the direction of UpJohn Pharmacia. The Professor in charge was Professor Karl LAFORGE and we had regular free radical meetings; at the time, people thought free radicals were hippies! (ha ha) But the free radicals we were discussing were reactive oxygen species (ROS) and their effects on medicine and biology.”

PM: “So what did UpJohn Pharmacia do with your research?”

RL: “They would typically study the effects of free radicals and other reactive-oxidant species, especially on the cardiovascular system. They had laboratory animals related to the chipmunk, and they would anesthetise them temporarily so they wouldn’t feel anything (nothing

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11

we did damaged the animals), and we would then stretch the pouch of their skin over a microscope to see the blood flow. We injected a dye, and then we further injected free radicals, and you could see the damage to the walls of the arteries, and then as a third step antioxidants were injected into their bloodstream, like glutathione, and you’d then see the damage repair itself after several minutes; for example, the arteries weren’t leaking anymore.”

PM: “I see.”

RL: “That gave us a clue to the damages going on in our bodies--and we were able to see it all for the first time in real time video.”

PM: “So oxidation is obviously a problem, what kind of problems does it cause in humans?”

RL: “Well, for example, if you are having breathing problems, such as asthma or COPD, then that could be because of a lack of glutathione, a powerful antioxidant that we demonstrated is important for repair in animals. If you don’t have enough glutathione in your lungs then you are likely to develop some kind of pulmonary disorder. With recent research, some of which I have done myself, we learned that the glutathione concentration level in the lung cells, the epithelial cells, is 140 times what it is in the bloodstream. Why is it so much? Because every day we are breathing in pounds of oxygen and we are generating free radicals in those epithelial lung cells--so we need to protect those cells from free radical damage, the same type we saw in the animals. In our lungs we need to maintain that 140 gradient to defend the cells against the intake of oxygen and its subsequent free radical damage.”

PM: “That makes sense. Are there any other conditions in humans that are strongly related to free radicals?”

RL: “Oh yes, many, like hardening of arteries. But there are some which we wouldn’t perhaps normally attribute to free radicals--for example, cataracts that form in the eyes, for which many people have surgery.

That’s an oxidation problem gone awry in the lens of the eye. Another is wrinkles in the skin. Hormones like IGF-1 help the body generate high levels of glutathione.

Glutathione is a key free radical scavenger, without which fine lines form around the eyes. Free radicals also affect the burning of fat. If your mitochondria are not burning fats and sugars properly then you gain weight as you age; this tells you that your energy factors are not working properly and the fat burning process is not what it was when we were younger.”

PM: “It is very well known that it was Professor 12

Denham Harman in 1956 who postulated the free radical theory of aging. I’d like to have your opinion please, Dr Lippman, between aging and free radicals.

What do you think?”

RL: “It is still somewhat unknown as to what it means exactly. But Dr. Harman did experiments which showed that with certain types of mice you get a 50% increase in mean lifespan. That was with a substance called BHT which we use in ACF228®. It works very well in animals, although we aren’t so sure in humans. We don’t really understand why this works still, to this day.”

PM: “I happen to know that you were nominated for the Nobel Prize in Medicine. Could you please elaborate why?”

RL: “Yes. In the early 1980s, I developed a system to directly measure free radicals and lipid peroxides in the bloodstream of humans. At the time and until this day, most people are measuring ORAC values. ORAC values are what one measures in a test tube. So 20,000 ORAC values apply in-vitro. But I developed a system to measure antioxidants in-vivo.”

PM: “That sounds very important indeed. The obvious next question is, armed with this information, what did you do with it?”

RL: “The next step was to do clinical double-blind, crossover studies on this fresh data. Together with a lot of volunteers we measured their normal free radical/ lipid peroxide production to see how different antioxidants would work to quench those radicals, to render inactive those radicals and other reactive oxygen species. For example, effects on the superoxide or singlet oxygen- to name two potent free radicals.”

PM: “So at this point you started to put a formula together to see if these radicals could be effectively neutralised?”

RL: “Yes, I put a protocol together and did extensive measuring that went on for months. I also measured animals, but mostly humans. With those data I was able to register a product with the Swedish FDA that would help to reduce free radicals in humans. Eventually, it was also registered with the Italian FDA and even sold in the Vatican with the blessings of the Pope!”

PM: “Wonderful! So your product exists today as ACF228®- how did that come about?”

RL: “After getting permission to sell it in Europe, I was able to get US and international patents. The attorneys that looked over my US patent said it was impossible to get a longevity patent, as there wasn’t a Ponce de Leon

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fountain of youth. But I achieved a patent based on such studies. For years afterward, people challenged some of the active ingredients and asked if it really worked. But then the NIA--the National Institute on Aging--in 2002 assigned 3 independent government labs to test the active ingredients in ACF228® on mice. All 3 labs confirmed that it extends lifespan in mice by about 8%--and then all the doubting Thomases were silenced! So now we had both European and American evidence that ACF228® was effective in both animals and humans.”

PM: “ACF228® has 15 ingredients. How did you go about determining them?”

RL: “I discovered something that was unique about the hierarchy of free radicals. I could divide them up in the human body into different lines of defense. I invented that terminology. Today you hear people talking about lines of defense in the body. Essentially there are 4 lines of defense; the first one is catalase, an enzyme that’s used in ACF228® that renders hydrogen peroxide into harmless water and oxygen. The second line of defense is superoxide dismutase; SOD converts the hydroxyl radical into ordinary water. ACF228® contains additional ingredients that activate our own SOD to defend against that radical. The third line of defense we have is the membrane bound vitamin E and C – which are not the type we take in ordinary supplements. The body only allows 1 molecule of vitamin E for every 50 lipid molecules in a cell wall, so we strengthen that with the ingredients in ACF228®. The fourth line of defense is the ubiquitous and powerful antioxidant glutathione. We have invented another product called ACF228® Breathe Easy, where you can breathe in the dust of glutathione and other antioxidants into the lung cells, as we discussed previously.”

PM: “So clearly the ACF228 Breathe Easy is going to a boon to anybody with asthma, COPD, or other breathing difficulties.”

RL: “Yes, especially if they are tired of using the antibiotics and steroids, which have serious consequences in long term use; you can’t use them for years at a time without other medical problems arising.”

PM: “Are there other important ingredients in ACF228®?”

RL: “ACF228® has a patented substance called NDGA, or Nordihydroguaiaretic acid. This comes from the Creosote bush that is found in deserts. It was discovered that these bushes can survive very high and dry environments.

For example in Death Valley, California there are temperatures of up to 150° F with intense radiation from the sun, yet these Creosote bushes survive. That led me to

discover this powerful antioxidant in them.”

PM: “Fascinating. I happen to know that Creosote bushes have one of the longest lifespans of flora of up to 13,000 years.”

RL: “Right, thanks to their protection from radiation via NDGA.” PM: “I think you’ve really covered a lot of ground for us in terms of the benefits of ACF228®, but I think we should ask if there are any side effects or contraindications.”

“I developed a system to directly measure free radicals and lipid peroxides in the bloodstream of humans.”

RL: “None whatsoever, since 2 European FDAs have tested it without issues and then the American government also found no side effects. So this is a very safe product.”

PM: “Good news indeed. So for anybody interested, how do they dose ACF228®?”

RL: “I think that many people who are not aging that fast, perhaps those under the age of 50, it’s okay to take 1 capsule per day. But for people who know they are aging rapidly--and they are usually over the age of 50-- then I would recommend 1 capsule per meal. Why? Because it is very easy to remember when you are eating to take 1 capsule with your food. One also might remember to take other supplements, too. Then you don’t have to have a special time in mind. Also, as they are food supplements, why not take them with food!”

PM: “Good advice. We’ve covered a lot of ground.

Is there anything else you would like to say in conclusion?”

RL: “I’d like to summarize by saying that many of the most toxic substances on the planet are generated internally in our cells, or externally by radiation. We naturally defend against these toxins with our cells’ 4 lines of defense. Fortunately, we can further boost these lines of defense with supplements such as ACF228® capsules and Breathe Easy, as well as IGF-1 and growth hormones.”

PM: “Dr. Lippman I would like to thank you for all your wonderful research and also all your valuable time that you have given us today.”

RL: “Thanks Phil, my pleasure.”

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13

Defend Yourself Against Free Radical Damage With

ACF228

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ACF 228® is a formula from Nobel Prize for medicine nominee Richard Lippman, Ph.D. ‘ACF’ stands for ‘Aging Control Formula’ and 228 is the number of versions it took to make this breakthrough. Dr Richard Lippman is a world authority on free radicals and peroxides and their effects upon longevity.

ACF228® has been double-blind clinically tested as described in US Patent Number 4,695,590.

ACF228® Dr Lippman’s 45 Caps $49.99

NEW: ACF228® Breathe Easy All the antioxidant power of ACF228® in a novel inhaler

IAS brings you ACF228® Breathe Easy which is a new type of inhaler that doesn’t contain steroids and can help with lung problems that cause excessive mucus and bronchial contractions.

ACF228® Breathe Easy 1 Tube $139.99

“73% of premature aging is caused by free-radical attack.” Dr Les Packard *Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

have a few drawbacks: short window of opportunity for its application, the risk of intra-cranial bleeding, and the fact that they have to be administered via injection. Anti-platelets and anticoagulants may be used acutely or as a secondary prevention. They work by limiting the spread or worsening of the ischemia but do nothing about the existing thrombus or embolus; it is up to the body’s own fibrinolytic system to resolve the clots. Like thrombolytics, antiplatelets and anticoagulants also carry the risks of causing unforeseen bleeding in spite of due care or testing. Is there not a safer and also effective option for treating or preventing ischemia besides the above categories of pharmaceuticals? The answer is “yes” and the agent that would fulfill those criteria is called lumbrokinase!

What is lumbrokinase?

Lumbrokinase – A circulatory hero with a humble origin

By Martin Kwok, BSc, MSAOM, ND Dr. Martin Kwok holds a naturopathic physician license and a doctor of Traditional Chinese Medicine license in the province of British Columbia in Canada. He has had a general practice in the heart of Richmond for over 17 years. Dr. Kwok also holds positions as the vice-president of Canada RNA Biochemical Inc., the secretary of National Traditional Chinese Medicine Association of Canada and the editor-in-chief of Dragon’s Medical Bulletin.

Heart attack and stroke are the two most devastating and common circulatory issues we face in our time. In majority of cases the cause is a severely reduced or completely blocked blood flow due to thromboembolism. Currently there are three main categories of pharmaceutical agents used to treat or prevent ischemia issues: thrombolytics, anti-platelets, and anticoagulants. Thrombolytics can be a lifesaver in acute situations when used appropriately, but

Lumbrokinase is a complex enzyme preparation extracted from earthworms. Lumbrokinase can also be referred to as earthworm powder enzymes (EPE) or earthworm fibrinolytic enzymes (e-PPA). Earthworms have been used in traditional Easter medicine for thousands of years in countries such as China, Japan and Korea. According to the ancient Chinese medical publication Ben Cao Gang Mu (Compendium of Chinese Botanical and Animal Products), earthworms or “Earth Dragons” possess the properties to “invigorate blood, resolve stasis, and unblock the body’s meridians and channels.” As a result, earthworms are commonly used in traditional herbal formulae that treat ischemic or thromboembolic conditions.

Inspired by the empirical wisdom of traditional Eastern medicine, the Japanese started searching for ingredients that could account for the observed properties of earthworms. Finally, in 1983 Dr. Hisashi Mihara succeeded in extracting powerful fibrin-dissolving enzymes from earthworms and he named this group of enzymes lumbrokinase. Since then Korean and Chinese researchers have compiled extensive in-vitro, animal and clinical data on the properties and applications of lumbrokinase over the past 30 years.

As of today, a simple PubMed keyword search of “lumbrokinase” would generate 46 results, with papers dating as far back as 1991 and as recent as April 2014. However, performing the same keyword search (in Chinese) in the largest Chinese digital periodicals

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15

database (www.cnki.net) would generate over 1400 publications! This paper is in no way an attempt to summarize all of the available clinical research on lumbrokinase, but merely to point out some of the clinically relevant highlights. Still, what is presented here is barely scratching the surface of its potential clinical applications.

“The biggest advantage lumbrokinase has over current thrombolytics, anti-platelets and anticoagulants is its safety record...�

Mechanisms of lumbrokinase

mize angina attack frequency, minimize the need for nitroglycerine and improve ST segment elevation on the EKG9-11,16. Other potential applications of lumbrokinase include deep venous thrombosis12, essential hypertension13, vascular dementia14, etc.

Unknown to most clinicians, lumbrokinase is now been investigated as a potential anti-tumor and anti-metastatic agent. There are various in-vitro and clinical evidence pointing towards the involvement of hyper-coagulation in stimulating tumor growth and metastasis. There are also evidence showing the potential use of anti-coagulants in limiting cancer growth and metastasis. Though still early in the research stage, lumbrokinase has been shown to inhibit stomach cancer cell growth and liver cancer cell metastasis in vitro20-22. Animal models and human studies are surely to follow in the near future.

Lumbrokinase is a multiple enzyme preparation; natClinical safety of lumbrokinase urally it also affects the coagulation system in multiple ways. Since the discovery of lumbrokinase by The biggest advantage lumbrokinase has over current Dr. Mihara in 1983, various researchers have isolated thrombolytics, anti-platelets and anticoagulants is the enzyme by different methods and also studied its safety record, especially with regards to bleeding its physiological properties in animal models. All of risks. Virtually all of the researchers who have ever the results pointed towards the fact that lumbrokistudied or published on lumbrokinase concluded nase possesses both direct and indirect fibrinolytic that it is a well-tolerated and very safe fibrinolytic effects1-2. It can activate the plasminogen system agent. The review paper by Wang et al. estimated and also can achieve direct fibrinolysis independent the overall adverse reaction rate to be about 3% with of the plasminogen system. In 2004, Zhang el al. dis- symptoms like mild headache, dizziness, constipacovered that lumbrokinase also inhibit PAI-1 activity tion, and nausea; all the symptoms resolved spontaand enhances t-PA activity3. In addition to being a neously after stoppage of medicine and required no strong fibrinolytic agent, lumbrokinase may indispecial treatment17. Another review paper by Tang et rectly achieve anticoagulation by inhibiting platelet al. reached an even lower rate of adverse reactions – functions. Jiang et al. were among the first research- 0.7%; though the authors believed this number to be ers to report on such a property4. an under-estimation18. The types of adverse reaction include nausea, vomiting, rash, skin itch, and dizziPotential clinical applications ness; there were no bleeding issues, nor damages to One of the most intensely researched areas is the use liver or kidney. of lumbrokinase in the prevention and treatment of Researchers and clinicians have long been baffled ischemic stroke patients. Lumbrokinase was shown and amazed by the efficacy and safety of lumbrokto be safe and effective for treating acute ischeminase as a fibrinolytic agent. Now it appears that ic stroke by lowering blood viscosity, preventing re-perfusion damage, and reducing neural deficits5-7. lumbrokinase, as a multi-enzyme preparation, not only has fibrinolytic effect but also prothrombin actiIt was also shown to improve the efficacy of aspirin vating effects. It is a coagulation modulator helping as a secondary prevention of stroke8,15. to maintain the balance of the coagulation system19.

Lumbrokinase is equally impressive in the treatment This research by Zhao et al. supports the notion that of coronary arterial diseases, including patients with lumbrokinase is a bi-directional agent, and is thereunstable angina. Besides lowering whole blood visfore much safer than any of the currently known cosity, plasma viscosity, fibrinogen, and ESR, research agents that affects the coagulation system. data indicated that lumbrokinase was able to mini16

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Advantages of lumbrokinase (Boluoke®) Not all lumbrokinase products are made the same.

Lumbrokinase is a mixture of enzymes from earthworms, thus different lumbrokinase manufactured by different companies will have slightly different properties due to the differences in the extraction and purification processes. There are also products that use ground-up earthworms or crudely extracted proteins, yet claim to contain pure lumbrokinase.

Boluoke® (lumbrokinase) is the proprietary lumbrokinase product that went through Phase I to Phase III clinical studies in China, the one first approved by the Chinese SFDA, and also the one with the longest history of safe clinical usage. For most clinicians Boluoke® stands for consistency in safety, quality, and efficacy. Below is a simple comparison table between Boluoke® and other lumbrokinase products: Parameter

Boluoke® Other Lumbrokinase

Phase I to Phase III trials done

YES

NO

Pharmacodynamics studies done

YES

NO

in traditional medicine has come a long way. First there was dried earthworms used in traditional oriental herbal decoctions, and then there were ground-up earthworm powders. Later came the granular crude extract of earthworms and now there is lumbrokinase, a purified multiple-enzyme preparation extracted from earthworms. Just like omega-3 molecules from fish oil, polyphenols from green tea and curcumin from turmeric root, in time lumbrokinase shall be known as the most valuable ingredients from the humble earthworms.

References 1. Ma EL, et al. Effects of Rongshuan No 1 (F-1) on the antithrombotic and antiplatelet aggregation. Journal of Shenyang Pharmaceutical University 2001;18(5):370-372.

2. He ZZ, et al. Separation and purification of earthworm fibrinolytic enzyme and the study of anti-thrombosis activity. Chinese Journal of Biochemical Pharmaceutics 2001;22(6):284-286.

3. Zhang J, et al. Experimental study on the effect of lumbrokinase on fibrinolysis in rats. Chinese Journal of Pathophysiology 2004;20(5):891-892.

4. Jiang DS, et al. Inhibition of platelet aggregation in hamsters by lumbrokinase extracted from Eisenia fetida. Journal of Capital Medical University 1994;15(4):291-294.

5. Yang M, et al. Eisenia fetida lumbrokinase research VI – thrombolytic effect in rabbits and protective effects in experimental stroke model in hamsters. Biotechnology 1995;5(3):9-11.

6. Li WY, et al. Observation of treating twenty-seven cases of ischemic stroke patients with lumbrokinase. New Chinese Medicine 2003;34(4):63-64.

Pharmacokinetics studies done

YES

NO

Toxicity & teratogenicity studies done

YES

NO

7. Zhang HY. Observation of treating acute ischemic stroke with lumbrokinase. Capital Medicine 2000;7(3):45-46.

SIGNIFICANTLY

8. Zhang DJ, et al. Prevention of ischemic stroke recurrence using lumbrokinase. Capital Medicine 2003;5(10):47-48.

Affects INR or aPTT

INSIGNIFICANTLY

Also standardized against tPA activity

YES

NO

Over 20 years of safe clinical usage

YES

NO

Contains corn ingredient

NO

YES

10. Yi XF, et al. Efficacy of treating unstable angina seniors with lumbrokinase. Capital Medicine 2002;9(9):57-58.

Professional Clinical Support

YES

MAYBE

11. Zhou HS, et al. Clinical observation of treating unstable angina seniors with lumbrokinase capsules. Central Plains Medical Journal 2001;28(9):2-3.

Current challenges of lumbrokinase Even though Lumbrokinase is a well-researched and clinically proven enzyme preparation, outside of Asian counties it is relatively unknown to most conventional practitioners. This is likely due to three main reasons: first, most of the available clinical data on lumbrokinase is in Chinese and not readily accessible to most clinicians or researchers; second, pharmaceutical grade lumbrokinase is expensive and hard to come by (primarily from China), thus only a few companies are selling and promoting its clinical use; third, major pharmaceutical companies have not found a way to profit from this enzyme, since natural proteins are not patentable. However, works have begun in further selecting and isolating lumbrokinase to one single enzyme, paving way for the eventual patenting of that particular enzyme via recombinant DNA technology.

9. Liu HS. Clinical observation of treating 60 angina patients with lumbrokinase. Tianjin Pharmacy 2002;14(2):45-46.

12. Song JS, et al. Clinical analysis of treating 17 cases of deep venous thrombosis with lumbrokinase. Occupation and Health 2001;17(4):111-115.

13. Ye SZ, et al. Observation of treating 51 cases of essential hypertension with lumbrokinase. Clinical Medicine 2007;27(9):59.

14. Gao Y, et al. Efficacy of combining lumbrokinase with nimodipine in the treatment of vascular dementia. Journal of Liaoning University of Traditional Chinese Medicine 2008;10(11):5-7.

15. Cao YJ, et al. Oral fibrinogen-depleting agent lumbrokinase for secondary ischemic stroke prevention: results from a multicenter, randomized, parallel-group and controlled clinical trial. Chin Med J (Engl). 2013 Nov;126(21):4060-5.

16. Kasim M, et al. Improved myocardial perfusion in stable angina pectoris by oral lumbrokinase: a pilot study. J Altern Complement Med. 2009 May;15(5):539-44.

17. Wang CL, et al. Progress in lumbrokinase. Progress in Veterinary Medicine 2009;30(11):86-90.

18. Tang YJ, et al. Lumbrokinase: A review of domestic research literatures. Capital Medicine 2011;18(6):39-42.

19 Zhao J, et al. Eisenia fetida Protease-III-1 Functions in Both Fibrinolysis and Fibrogenesis. J Biomed Biotechnol. 2007;2007(5):97654.

20. Li HY, et al. Antitumor activity of earthworm fibrinolytic enzyme. Chinese Pharmacological Bulletin 2004;20(8):908-910.

21. Chen H, et al. Effect of earthworm fibrinolytic enzyme on the inhibition of invasion and metastasis in hepatocellular carcinoma cell. Jiangsu Medical Journal 2008;34(4):383-385.

22. Chang CX, et al. Anti-metastatic activity of earthworm fibrinolytic enzyme on hepatoma cell in vivo. Traditional Chinese Drug Research & Clinical Pharmacology 2009;20(6):520-524.

The use of earthworms to achieve circulatory health www.antiaging-systems.com // Order hotline: 1-866-800-4677 // e-mail: ias@antiaging-systems.com

17

BLOOD FLOW The Heart of The Matter

Harnessing the power of a far-Eastern traditional medicine, Boluoke® prevents the blockages that cause heart attacks and strokes, the biggest cause of premature death in the world.

Boluoke® safely hinders a protein which is integral to the coagulation process but importantly, it doesn’t affect the blood’s ability to haemorrhage.

Benefit from the combination of ancient wisdom and modern technology, keep your blood

flowing smoothly with Boluoke®, a safe, effective enzymatic supplement with distinct advantages over common products such as Warfarin.

Boluoke® 60 Capsules $94.99

*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

Dr Ward Dean answers your questions

We are delighted that Ward Dean, M.D., one of the world’s foremost antiaging physicians, has agreed to answer our readers’ questions. Full details about Dr. Dean can be seen at his website: www.warddeanmd.com

Dear Dr. Dean “I am a 50 year old man in decent health- certainly with no medical conditions. I have never smoked, I drink alcohol rarely and do my best to eat and live well. Recently I have had some stabbing pains in my toes/ feet and occasionally in my hands. This usually occurs when I lie down to sleep. It is not debilitating, more frustrating.

However if it is a prequel to some problem, I would rather deal with it now and therefore would greatly appreciate your opinion.”

P.M., Ireland

Dear Mr. P.M., Based on the limited information provided, the problem seems to be most likely some kind of neuropathy or ‘mini-seizure.’ How long has this been going on, and is it getting worse over time?

restful sleep) and does not adversely interact with other medications. (2) When properly dosed, patients experience sound, restful sleep, and awaken feeling refreshed. If you are groggy upon awakening; (at any dose) then try reducing the dose, or taking it earlier in the evening. The usual effective dose is 600-800 mg at bedtime, but some very sensitive people need only 300 mg and some require up to 1800 mg.

The dose of 2400 mg per day is the usual maximum dose, although dosages as high as 3200 mg have been reportedly used.

Lithium Orotate acts as a ‘nerve stabilizer,’ and may be helpful in your situation. Lithium Orotate is 20 times more bioavailable than prescription forms of lithium and can therefore be used in fractional doses compared to the prescription forms of lithium. Because of the low doses used, blood ‘lithium levels’ are not necessary, as are required with prescription lithium. Let me know how you do.

Several suggestions would be to try Benfotiamine, about 300 mg twice per day and Gabapentin (Neurontin®) at bedtime, in a dose ranging from 300-1800 mg. A third suggestion is to add Lithium Orotate (2 caps twice daily).

Ward Dean, M.D.

Benfotiamine is a fat-soluble form of vitamin B1, which has been shown to be of benefit in diabetic and peripheral neuropathy.

References:

Neurontin® is an anti-seizure medication that is used for a number of conditions, including peripheral and diabetic neuropathy, restless legs, alleviation of menopausal hot flashes (unrelated to your condition of course), and insomnia. (1) I usually start my insomniac patients on 600 mg at bedtime, and have them titrate the dose up or down to what works for them. Neurontin® is remarkably free from side effects, (other than causing drowsiness and inducing sound,

[Ed. - Benfotiamine, Gabapentin and Lithium orotate are all available from IAS].

1. Lo HS, Yang CM, Lo HG, Lee CY, Ting H, Tzang BS. Treatment effects of gabapentin for primary insomnia. Clin Neuropharmacol. 2010 Mar-Apr;33(2):84-90.

2. Karam-Hage, M., BROWER, KJ. Gabapentin treatment for insomnia associated with alcohol dependence. Am J Psychiatry 2000;157:151-151.

“I am particularly interested in what Dr. Dean might have to say about the recent link claimed between testosterone and heart attack, stroke, etc. I have been on a pro-

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gram using testosterone cypionate for replacement with wonderful results for the last ten years. I would love to hear his comments.”

L.G., USA

Dear Mr. L.G., Thanks for giving me the opportunity to address this important issue. Your question is based on publicity surrounding the study in the November 6th, 2013 issue of the Journal of the American Medical Association (JAMA-1), which frighteningly concluded that “the use of testosterone therapy was associated with increased risk of adverse outcomes.”

This was a shockingly flawed study, with more holes in the data and their interpretation than a block of Swiss cheese. I am amazed that this paper was ever published--especially in such a prestigious journal.

Let me put things in perspective. The paper was a “retrospective cohort study,” conducted by a review of medical records from 76 cardiac catheterization laboratories in the VA system. The study involved the records of 8,709 men who had undergone coronary angiography, between 2005 and 2011 who had testosterone levels less than 300 ng/dl.

Of the 8,709 “participants,” 1,223 were in the “testosterone group.” This testosterone group was a hodge-podge comprised of those who had received one prescription for testosterone (17.6%) or more than one (82.4%). Thirteen of the men (1.1%) were treated with topical gels, 436 (35.7%) with injections, and 774 (63.3%) with patches. Of those who had received “more than one prescription,” the mean number of days from first fill to last fill of testosterone was 376 days. Of the patients in the testosterone group, 734 (60%) had a subsequent testosterone level drawn. The baseline testosterone in the treatment group was 175.5 ng/dl- -and (for the 60% who had follow-up testosterone levels checked) testosterone was increased to only 333.2 ng/dl.

The statisticians who wrote the study used “stabilized inverse probability of treatment weighting” to assess the association between testosterone therapy and the primary outcome of death, heart attack, and stroke, and used a number of variables to create these “weights,” including “comorbidities” (41 diseases) and “procedures” (13 procedures).

The authors reported in the introduction that of the 7,486 patients not receiving testosterone, 681 died, 420 had heart attacks, and 486 had strokes. Of the 1223 patients who had received testosterone, 67 died, 23 had heart attacks, and 33 had strokes.

I am not a statistician. I was never very good at math. But it is pretty easy to calculate that there were 6 times the number of patients in the no-treatment group compared to those who received testosterone. If we multiply the number of adverse outcomes in the testosterone-treated group by 6, we arrive at only 402 (6 x 67) who would have died in the treatment group (versus 681 who died in the no treatment group); 138 (6 x 23) who would have had heart attacks in the 20

treatment group (versus 420 no treatment); and 198 (6 x 33) who would have had strokes (versus 486 no treatment).

Thus, it is a complete mystery to me how the authors, using their advanced statistical manipulations, arrived at their clearly erroneous conclusion that “the use of testosterone was associated with increased risk of mortality, MI, or ischemic stroke,” when the results plainly indicate that testosterone use resulted as in a much lower percentage of adverse events. This confirms the old adage that “figures don’t lie but liars can figure.”

The statistical anomalies are not the only flaw in this study.

Recall that to be enrolled in this study; a subject had to have undergone coronary angiography. Obviously, these men had all already been determined to be at risk for death, heart attack or stroke (the “end points” of the study) due to their having been referred for angiography. Healthy men do not undergo coronary angiography.

The other criterion for inclusion was testosterone levels less than 300 ng/dl. A recent study in the Journal of the American College of Cardiology evaluated the relationship between testosterone levels and risk of cardiovascular (CV) events in 2,416 men aged 69-81 years, over five years.(2) The researchers found that testosterone levels were inversely associated with the risk of CV events (i.e., those with the highest testosterone had the fewest “events”). They reported that men in the highest quartile of testosterone (those with more than 550 ng/dl), had a lower risk of CV events compared to the men in the 3 lower quartiles (recall also that the men in the testosterone-treated group in the JAMA study raised their testosterone to only 332.2 ng/dl). The researchers concluded that “High serum testosterone predicted a reduced 5-year risk of CV events in elderly men.” [Emphasis added] Another recent study of 1031 male veterans over age 40 with low testosterone (less than 250 ng/dl) also contradicts the JAMA study. (3) In this paper, 398 of the patients were treated with testosterone. The mortality over 5 years was 10.3% in the testosterone-treated men versus 20.7% in the untreated men. The authors reported that “testosterone treatment was associated with decreased risk of death.”

More recently, three eminent physicians reviewed the JAMA study. (4) They stated that “We have serious concerns regarding the validity of these results based on author errors, study design, data presentation, methodology, and ultimately common sense.” They examined the JAMA article point-by-point, and concluded that “We believe the evidence to date strongly suggests that testosterone therapy improves CV risk. We reject the assertion by Vigen et al., “that testosterone therapy increases CV risks or mortality.”

If this is not enough to set your mind at ease, consider the other potential benefits of testosterone therapy that were curiously conceded by the authors of the JAMA study--testosterone replacement therapy improves sexual function, (57) bone mineral density, (8, 9) increases free-fat mass (8, 9) and strength, (10) improves lipid profiles (11-13) and insulin

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resistance, (11, 12) and increases the time to ST depression during stress testing. (14, 15) My only caution to those using testosterone supplementation is to monitor the CBC (to insure that the hematocrit does not rise above normal, causing “thicker” blood) and estrogen levels (testosterone aromatizes into estrogen, which can be controlled with low doses of anastrozole) and to maintain the testosterone level in the “safe” range, i.e., above 550 ng/dl.

Ward Dean, M.D. [Ed. - Testosterone itself is a controlled substance and therefore difficult to import and export. However, the testosterone increasing substances IAS offer are AndroPro™ and Testoluten® (a peptide bioregulator). Also, consider that DIM and the aromatase inhibitor anastrozole, (Arimidex®) skew the testosterone/ estrogen balance in favor of testosterone].

References: 1. Vigen R, O’Donnell CI, Barón AE, et al. Association of testosterone therapy with mortality, myocardial infarction, and stroke in men with low testosterone levels. JAMA. 2013;310(17):1829-36.

2. Ohlsson C, Barrett-Connor E, Bhasin S, et al. High serum testosterone is associated with reduced risk of cardiovascular events in elderly men. The MrOS (Osteoporotic Fractures in Men) study in Sweden. J Am Coll Cardiol. 2011 Oct 11;58(16):1674-81.

3. Shores MM, Smith NL, Forsberg CW, Anawalt BD, Matsumoto AM. Testosterone treatment and mortality in men with low testosterone levels. J Clin Endocrinol Metab. 2012 Jun;97(6):2050-8. doi: 10.1210/jc.2011-2591. Epub 2012 Apr 11.

4. Traish, AM, Guay, AT, and Morgenthaler, A. Death by Testosterone? We Think Not! J Sex Med, 2014; 11:624-629.

5. Wang C, Swerdloff RS, Iranmanesh A, Dobs A, Snyder PJ, Cunningham G, Matsumoto AM, Weber T, Berman N; Testosterone Gel Study Group. Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. J Clin Endocrinol Metab. 2000 Aug;85(8):2839-53.

It slows the conversion (digestion) of complex carbohydrates like bread, pasta, rice, beans and starchy vegetables into simple carbohydrates (sugar). I suggest chewing one 100 mg Acarbose tablet with each starchy meal. The most common side effect is intestinal gas—which is not caused

by Acarbose, but by the undigested food fermenting in the intestines. This is a signal that Acarbose is doing its job, and you are eating the wrong foods. But it provides you with a “cushion” for your diet. Incidentally, Acarbose is the most widely used anti-diabetic drug in China. (1) I incorporate Acarbose into the weight-loss programs of many of my patients.

Another class of anti-diabetic drugs to consider is the DPP4 inhibitors, such as Onglyza, Tradjenta, or Januvia. Discuss these with your physician, and see if he will prescribe one for you. DPP-4 inhibitors work well with Metformin, and further help restore insulin receptor sensitivity. These drugs also help regenerate pancreatic beta cells, to help your body produce its own insulin. They are all generally useful adjuncts for weight loss.

Yet another class of medications you might add is Victoza—the glucagon-like peptide-1 (GLP-1) agonist Victoza® (liraglutide). This drug is injected (like insulin), but unlike insulin, will not cause hypoglycemia. Victoza® appears to be even more effective than the DPP-4 inhibitors for helping with weight loss. None of the drugs that I suggested above will cause hypoglycemia. They all act by different and complementary mechanisms to normalize your blood sugar, and will enable your insulin to work more efficiently. Your requirement for insulin will be decreased, and you will most likely need to reduce your dosage. That will be beneficial for weight loss, as insulin is the hormone that drives blood sugar into the cells, where it is stored as fat. Hopefully, you will be able to eliminate the insulin entirely, although this may not be possible if you are truly a Type I Diabetic.

In addition to controlling your diabetes, I think it is very important for you to correct your abysmally low level of Vitamin D. IAS has a convenient, once/week capsule that contains 50,000 IU of Vitamin D-3.

I hope these suggestions will be helpful for you.

“I am a type-I diabetic patient, on an insulin pump. I also take 1,500 mg of Extended Release Metformin each day. I suffer from obesity, and am trying to lower my HbA1c to a 6. I am enclosing my personal report from my physician for the past 5 years. Can you give me any suggestions please?”

D.N.A., Dubai

Sincerely, Ward Dean, M.D. [Ed. – Metformin is available from IAS in 500 mg and 850 mg tablets as well as a slow release form. Acarbose (Glucobay®) is also available. Vitamin D3 is available in either 5000 IU or 50,000 IU capsules].

References:

Dear D.N.A. Thanks for sending your lab work and the note from your physician. First, I think you should increase your dose of Metformin to 1,000 mg twice daily. Next, I recommend you add several other anti-diabetic medications to your regimen. Acarbose (available from IAS) is a “starch blocker.”

1. Standl, E., and Schnell, O. Alpha-glucosidase inhibitors 2012— cardiovascular considerations and trial evaluation. Diabetes & Vascular Disease Research 9(3) 163-169.

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Fight Age Related Decline with

Testosterone Therapy

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Andro Pro™ Andro Pro™ contains the latest cuttingedge nutritional ingredients to naturally boost free testosterone levels. · According to a clinical study on 13 men who were given the equivalent of one capsule of Andro Pro™ daily for 60-days, serum levels of free testosterone increased by 29.5% · Contains the supporting agents of zinc, B6, magnesium and high quality tribulus terrestris

Andro Pro™ 60 Capsules $49.99

Testoluten®

(peptide bioregulator Testes) Testoluten® is a peptide bioregulator specifically harnessed to boost and protect the function of the testes.

• Helps maximise the production of semen and testosterone by the testes • Helps redress issues of low testosterone • Serves the same role as peptide bioregulators developed naturally in the body

Testoluten® 20 Capsules $79.99

*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

glycosylation and mitochondrial decline.

UPDATE: ACF228 is now also available in a specially

Featured products

designed mouth inhaler. The ACF228 Breathe-Easy can help those worried about their lung capacity and function, to help protect against oxygen deprivation and hopefully avoid the need for long term use of corticosteroids. In addition to the original ACF228 formula it also contains glutathione.

For further details about ACF228 and much more besides we recommend Dr. Lippman’s latest book ‘Stay 40.’

1st Line™ (thiocyanate) 1st Line is an exciting new and all natural weapon in the fight against various types of infections including viruses. 1st Line contains a patented formula that when made up with water becomes a drink that contains thiocyanate ions.

Adrafinil (Olmifon®)

Thiocyanate ions (also known as oxythiocyanate) are the same molecules made in body’s airways and passages, for example they can be found in tears, saliva and milk and they literally form the body’s first line of defence against all types of bacteria, yeasts, fungi, flukes, germs and even viruses, helping to destroy them on contact. Consuming 1st Line helps to flood the bloodstream with thiocyanates, but unlike antibiotics 1st Line does not attack self-molecules, in other words beneficial floras are not disturbed.

Clinical trials have exposed that 1st Line can help quickly to combat various infections relating to helicobacter, pneumonia, soft tissue infections, upper respiratory tract infections and bronchial infections. Other doctors have reported to us that their patients with various viral infections are asymptomatic, even months later after using a few doses of 1st Line. “...thiocyanate ions are not toxic to human cells... and have little if any effect on probiotic species, making them a near perfect antibiotic system.”

Professor Paul Clayton

ACF228™ Dr. Lippman was nominated for the Nobel Prize in Medicine for his work to measure free radical production within the body and as everyone knows free radicals are unstable molecules that cause a lot of damage associated with aging and degeneration. The result of Dr. Lippman’s work is unique to IAS - ACF228 (this stands for ‘antiaging complete formula’ version 228). The capsules are designed to neutralise damaging free radical production and help to reduce other age related damaging effects such as

Adrafinil works like modafinil- it resensitizes alpha-1 receptors in the brain to be more sensitive to noradrenaline. This heightens awareness and concentration to prevent narcolepsy (sleeping in the daytime). The results can be quite remarkable, leading to heightened states of awareness and attention, whilst at the same time not affecting sleep patterns nor causing ‘highs and lows’ that were associated with the earlier form of stimulants. Adrafinil is not recommended for continuous use past 3-months unless liver enzymes are being monitored.

Aminoguanidine (pimagedine) Aminoguanidine is internationally recognised as the most potent AGE inhibitor currently available. The abbreviation AGE means ‘advanced glycated end products.’ AGEs are cross linked proteins that do not work efficiently/ correctly and are seen in a number of disorders including diabetes, heart enlargement, skin discoloration and hardening (particularly in smokers), cataracts and even arterial stiffness. (If you want to see glycosylation in action, then cut an apple in half and watch it turn yellow and tough).

Our aminoguanidine tablets also contain vitamin B6 so there is no need for extra supplementation.

Andro-Pro™ Andro-Pro contains the latest cutting-edge nutritional ingredients to naturally boost free testosterone levels. The most unique ingredient added to Andro-Pro is the recently discovered fructoborate. Fructoborate is a boron derivative that according to Romanian

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studies is helping to alleviate bone loss and arthritis; but perhaps the most interesting clinical study was done on 13 men. They were given the equivalent of one capsule of AndroPro daily for 60-days, at the end of the 2 months, on average these men experienced serum level increases of vitamin D by 19.6%, DHEA-S up 56% and free testosterone rose by 29.5%.

In addition, Andro-Pro also contains the supporting agents of zinc, B6, magnesium and high quality tribulus terrestris. All factors in improving free testosterone production.

Adding DIM-Pro 2™ to your regime can help to reduce estrogen levels and therefore improve free testosterone levels even further.

ATP Boost™ ATP-Boost provides 20mg of ATP, the body’s ultimate energy molecule in each capsule. In addition, ATP Boost contains a unique combination of the nutrients acetylL-carnitine and R-lipoic acid that increase mitochondria energy production without the increase in damaging oxidation that usually follows. The result: enhanced energy reserves and reduced aging at the cellular level.

BCI program Dr Garry Gordon is a world expert in detox and chelation (the removal of heavy metals). His oral BCI program is a world leader. Made up of 3 products, it not only provides the right natural materials to help lock-up, remove from tissues, transport through the body and excrete toxins, but also a plethora of protective vitamins, minerals and oils that have been designed to make it as easy as possible to have the most comprehensive all-in-one package.

the gut from the body. Simply add a scoop of the powder into your morning cereals or blend it into your power drink.

UPDATE: For those who want to get metals out of their skin, use Beyond Clean® version 2. This powder is simply added to the bath tub and contains both EDTA and zeolite. Here you simply relax your toxins away!

BEC5 Curaderm® BEC5 Curaderm cream was discovered

by Dr. Bill Cham on the Oceania island of Vanuatu. Dr. Cham noticed that when the local farmers rubbed the plant called the ‘devil’s apple’ (found in that region and which is related to eggplant) onto the backs on animals that were experiencing skin cancers - that they had considerable success in its removal.

It is known that BEC5 Curaderm has now been used by more than 80,000 patients, all with remarkable success. Clinical trials in the UK and Australia have confirmed the ability of BEC5

The eggplant cancer cure by Bill Cham Ph.D. covers all aspects of BEC5 Curaderm treatment.

Curaderm to regress non-melanoma skin cancers within weeks!

For example, one open study with 72 patients had 100% healed skin cancer lesions within just 13-weeks of applying BEC5 Curaderm cream twice daily.

Each sachet in the Beyond Chelation Improved® contains 3 vitamin/ mineral pills, 3 chelation/ detox capsules, 1 omega 3 fish oil capsule, 1 omega 6 & 9 evening primrose capsule and 1 brain capsule containing gingko biloba and phosphatidylserine.

This is a superb daily nutritional supplement just by itself, but to avail yourself of the full program you should add two more agents; Bio-En’R-Gy C® a unique high-strength and stabilised vitamin C powder that can be added to water or juice. It also contains ribose for your heart health along with MSM, betaine and bioperine to lower inflammation and problematic lipids.

Fundamentally, it is this product that transports the toxins from the tissues sites that Beyond Chelation Improved® has released, ready for them to be excreted.

Then it is over to Dr Gordon’s Beyond Fiber®. It contains the best forms of fiber, specifically extracted from brown rice husks and Jerusalem artichoke, in addition with EDTA. This product enables the body to defecate the toxins collected into 24

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“BEC5 Curaderm is a topical preparation which is safe and effective, an ideal therapy for outpatient treatment... It is a cost effective treatment for both primary and secondary skin cancer care.” Dermatologists at the Royal London Hospital Examples on opposite page showing examples of patients before, during and after treatment with BEC5 Curaderm.

A typical treatment period from start to finish is 8 weeks.

Furthermore, BEC5 Curaderm is known not to harm healthy cells, therefore only destroying cancer cells on and under the skin’s surface.

The most commonly expressed initial reports are that glare is significantly improved, (for example night driving is much safer) and color perception is enhanced.

What’s more evidence is mounting that Can-C is efficacious for all of the following disorders: cataracts, glaucoma, presbyopia, corneal disorders, eye strain, ocular inflammation, blurred vision, dry eye syndrome, vitreous opacities and lesions, diabeteS mellitus complications, contact lens wearers, (regarding the last point in the list above, Can-C inhibits the accumulation of lactic acid which has greatly benefited those who wear contact lenses, because it enables them to be worn for longer without pain).

“What’s near perfection? BEC5 Curadermit’s a treatment that works nearly every time.

It’s incredibly simple to use, has no adverse side effects and is inexpensive compared with other treatments.” Jonathan Wright, M.D. BEC5 Curaderm is known to be effective for all the following conditions:

• • • • • •

Basal cell carcinomas (BCC) Squamous cell carcinomas (SCC) Keratoses Keratoacanthomas Age spots Sun spots

Dr. Kyriazis book, ‘the cataract cure’, details the usefulness and evidence of Can-C eye-drops.

Now available from IAS as a FREE e-book: http://www.antiaging-systems.com/can-c-ebook

UPDATE: To achieve the best possible results in the quickest possible time, use HemaGel® and tamanu oil following the BEC5 treatment.

Can-C™ eye-drops Can-C eye-drops are the original formula for use in cataract and contains a purified and racemized form of n-acetylcarnosine, a natural di-peptide with potent antiglycating and anti-oxidant properties that prevent lipid peroxidation.

Patients in trials placed 2-drops of Can-C into their eyes twice daily. After 6-months of use, 88.9% of patients showed improvement in the clarity of their lens and 90% saw an improvement in their visual acuity.

There have been numerous reports of cataract shrinkage and even disappearance with documented evidence that Can-C eyedrops remain effective (and safe) more than 24-months later.

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Left: A woman’s eye shows the cataract before treatment.

Right: 5-months later after use of Can-C eye-drops (two drops twice daily), there is no longer a visible cataract and eyesight has improved.

“I am so grateful for the development of Can-C eye-drops, not only have they significantly improved my own eyesight, but many of my patients report most favorably about them too.

Now we have a real alternative to eye surgery so Can-C can be considered to be a genuine breakthrough.”

Richard Lippman, Ph.D.

Can-C Plus™ Can-C Plus capsules are specially designed to be used alongside the Can-C™ eye-drops to aid and even boost their effectiveness. As there are a few supplements that can block the action of Can-C eye-drops, Can-C Plus capsules have been carefully designed to avoid them. Three Can-C Plus capsules a day can be taken with food, with or without Can-C eye-drops, although for maximum benefit it is recommended that they are used together.

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Centrophenoxine (Centro-Pro™) Like all good antiaging supplements, centrophenoxine has many useful features with few side effects. From a memory and cognition viewpoint, centrophenoxine has demonstrated significant improvements, most notably its ability to speed up the process of memory recall.

One of centrophenoxine’s most noted benefits is its ability to effectively and quickly remove a cell toxin that accumulates with age (and Alzheimer’s disease) called lipofuscin. Lipofuscin can make up parts of the socalled Alzheimer brain plaques, but it can even be found in the brains of ‘normal’ aging people as well as other organs such as the heart, the lungs and even the skin- where it forms part of the so-called age or liver-spots, the brown flecks found in ‘aged’ person’s skin. Indeed several weeks of centrophenoxine supplementation has seen removal and lightening of such spots.

“Centrophenoxine has shown many facets to improve conditions related to my membrane hypothesis of aging, for example its ability to improve brain-performance, survival time in animal experiments, and to remove the cell aging-pigment called lipofuscin. It has been my antiaging supplement for more than 30-years.” Professor Imre Zs.-Nagy

CoQ10 (coenzyme Q10) CoQ10 is a universal energy agent that has significant protective qualities for the heart and the cardiovascular system. An important point- anyone taking a statin drug to lower cholesterol must also be taking CoQ10 since statins lower CoQ10 levels.

UPDATE: Our CoQ10SR™ is a slow release version

combined with cyclodextrin, a new technology that enables greater bioavailability by improving the passage through the stomach into the blood. It has been clinically shown that CoQ10SR™ has up to twice the bioavailability of ‘regular’ CoQ10. Thus depending on how you look at it, CoQ10SR is either double the effectiveness of CoQ10’s of the same dose, or half the price of CoQ10’s of twice the dose!

Curcumin™ By harnessing the power of the natural healer, curcumin, (found in turmeric) we have access to a wide-ranging set of positives. From bolstering the immune system, to moderating inflammatory responses, it can also act as an anti-viral and an anti-fungal agent. It’s even been found to have the ability to 26

counter many conditions including a very recent study as an antidepressive.

UPDATE: Our CurcuminSR™ is a

unique slow release version that is much more bioavailable than regular versions.

Deprenyl (selegiline) Parkinson’s disease is characterised by the loss of the brain neurotransmitter dopamine.

Deprenyl helps to prevent this loss by acting on the specific enzyme MAO-b. Professor Knoll also believes that deprenyl very significantly increases PEA (phenylethylamine) and that this may have an even more significant function than the MAO-b inhibition, (for more details on this please read Professor Knoll’s excellent book on the subject- ‘the brain and its self’).

Professor Jozeph Knoll of Debrechen University in Hungary- the inventor of deprenyl

In addition to improving dopamine levels, deprenyl has also been shown to help rebalance serotonin, noradrenaline and acetylcholine levels and whilst the uses remain ‘off-label’ deprenyl has been used for Alzheimer’s and even cancer treatments.

Our focus here is upon deprenyl’s enhancement of dopamine, which is a key brain chemical responsible for drive, focus and well being and even libido (especially for men).

The experiments of Professor Jozeph Knoll dramatically extended the lifespan of rats who were given deprenyl.

Even the first rat to die that was treated with deprenyl died after the last rat not treated with deprenyl died.

This graph highlights the loss of dopamine with age, on average 13% per decade past the age of 40 for the average person, but far greater for those suffering from Parkinson’s disease

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The idea behind the antiaging use of deprenyl is to use very small doses regularly in order to help maintain healthy dopamine levels and thus improve cognitive function and help to maintain function at a better level for much longer.

UPDATE: The Dep-Pro™ liquid can dispense selegiline HCL in small quantities as 1 drop = 1 mg.

Esnatri™ cream (bio-identical estrogens) Esnatri cream is the world’s only bioidentical estrogen cream to replicate the work of Dr. Jonathan Wright. Dr. Wright has highlighted that the ‘average’ woman produces estrogens in the ratios of estriol 90%, estradiol 7% and estrone 3% and these are the exact same ratios found inside Esnatri. Each 1ml of Esnatri cream provides 2mg in total of the triple estrogens and it enables a precise, natural and indeed bioidentical hormone replacement therapy for women concerned about the menopause. IAS provides dose and timing advice from Dr. Wright for both estrogens and progesterone with every purchase. The additional use of bioidentical progesterone should be used along with an estrogen replacement program.

For further information on estrogens we recommend one of Dr. Thierry Hertoghe’s Hormone handbooks.

Hair-Pro™ Hair-Pro is the very latest development to help induce hair growth. It contains the absolute latest cutting-edge growth factor technologies.

Hair Pro is a unique proprietary topical liquid blend that includes finasteride, (the DHT blocking drug used orally for years as a hair loss treatment).

It also contains a plethora of amino acids that act as hair growth factors including bFGF, TRX, VEGF and IGF-1. In addition there is aminosyn to promote protein synthesis (hair strength), hyaluronic acid to aid hair hydration (thickness) and dexpanthenol to cleanse the pores of the blocking fat- sebum which can block nutrition from the hair root. It’s a unique and potent formula to battle alopecia.

UPDATE: Use it in combination with the Scalproller to improve uptake into the scalp.

HemaGel®

GABOB (Gamibetal®) Technically it is the closest legal molecule to GHB. Its approved use in Europe is to help with epilepsy, but like GHB, GABOB has been shown to improve growth hormone release significantly when taken before bedtime. GABOB does not have the ‘sleep inducing’ effects of GHB, but it can cause some sedation if taken in high doses.

GHRP2 GHRP2 is growth hormone releasing peptide number 2. It is a potent releaser of HGH for fat loss and is particularly synergistic with sermorelin. It is best taken in the morning, by swallowing 4ml of the liquid. Up to 10ml may be used for shorter periods of time.

UPDATE: The work of Dr Richard Walker highlights that

GHRP2 is particularly effective/ synergistic when combined with sermorelin.

Glutathione (also see ACF228™ Breathe-Easy)

Glutathione is a potent antioxidant that helps to prevent damage to important cellular components that can be caused by reactive oxygen species such as free radicals and peroxides.

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Glutathione is principally synthesized inside the body and is relatively poorly obtained via the diet. The Advanced Cellular Glutathione supplement is a spray providing nano sized particles for sub mucosal absorption to create instant bioavailability.

HemaGel was created in the Czech Republic and specially designed to help improve the treatment times of wounds, scratches and cuts, reducing the start-tofinish treatment time by as much as 50%.

It does this (1) by absorbing harmful and damaging free radicals and (2) by helping to absorb blood and puss extrudes, thus also keeping the wound cleaner. HemaGel is recommended for use after BEC5 Curaderm applications to speed up the skin’s healing. It is also as an excellent product to have in the First Aid cabinet- just in case! Simply apply the HemaGel daily onto a cleaned (and disinfected) wound, and then apply a bandage over it.

Hydergine (ergoloid mesylate) Hydergine is an extract of a fungus that grows on rye called ergoloid mesylate.

Its approved uses have been to aid persons with memory disturbances, Alzheimer’s disease and even for persons who have suffered from electric shock, drowning or suffocation. This is because hydergine stabilises the levels of oxygen in the brain. It has been shown to improve oxygen levels when they are too low and decreases levels when they are too high. The result of this optimised oxygen availability in the brain is an ability to do more mental work without becoming tired. Accordingly, hydergine can be a good

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tool to battle through boring paperwork or a long drive home in the dark. A fascinating animal experiment showed a special ability for hydergine to improve mitochondrial condition.

The mitochondria are vital organelles found in every cell of our body responsible for the generation of ATP, the universal energy molecule. Unfortunately mitochondrial efficiency declines as we age. However, an Italian study highlighted that old animal mitochondria can be improved with hydergine supplementation.

The Bertonin-Freddari et al, 1994 study highlights that hydergine can improve the size, volume and number of mitochondria in old animals- towards the youthful example; as is shown here the difference between young, old (without hydergine) and old (with hydergine) is significant.

Hydergine also stimulates the growth of dendrite nerve fibers.

These connective strands are known to decline in aging. This is another antiaging feature of hydergine. Some have even linked the density and numbers of dendrite fibers to the level of I.Q. In summary, hydergine helps to protect against conditions of hypoxia and peroxidation, important factors to guard against a stroke and generalised brain injuries. Hydergine can extend the boundaries of mental workload and energy, fighting against boredom and may even provide some groundwork for raising the levels of intelligence.

Melatonin (MZS™) Melatonin is one of nature’s remarkable substances. It is made in response to darkness by the pineal gland. Melatonin’s benefits to help overcome jet lag and shift work have become quite well known and indeed it is useful for this purpose since adequate melatonin availability enables our bodies to be correctly in tune with our circadian rhythms.

These circadian rhythms dictate our hormonal cyclicity and this cyclicity ultimately determines our aging and our level of immunity. Unfortunately melatonin secretions decline with aging. Professor Pierpaoli has published widely on melatonin, principally through the New York Academy of Science and at the meetings of the Stromboli conferences on aging and cancer- which IAS is delighted to support. What is important to know about melatonin is that Professor Pierpaoli advocates a 3mg dose to (his words) “put the pineal to sleep.” In addition, it is also vital to use a melatonin that produces a night peak of melatonin that is the same as the peak produced by the pineal itself. Thus he has achieved using specific excipients in his own formula ‘MZS™’ (which also contains the additional synergistic ingredients of zinc and selenium).

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This graph highlights that Professor Pierpaoli’s Melatonin Zn Se formula mimics the night peak of melatonin. Note that sublingual melatonin tested peaks too soon and that time released formulas peak too late.

Here are some before and after Fundus photos showing the benefit of Melatonin Zn Se. They highlight dramatic improvements to both wet and dry forms of macular degeneration. In a trial published in the New York Academy of Science, 110 eyes, (100 patients) with both wet and dry forms of ARMD were treated only with 1 tablet of Melatonin Zn Se nightly. After 6-months 90% of the treated patients’ eyes had significant improvements to their condition. This is simply remarkable compared to the current approved therapy for ARMD which involves injecting the eye quarterly, (costs $1000+) with 50% improvement at 24-months!

For further detailed information about melatonin and Professor Pierpaoli’s work we recommend his book ‘the key of life,’ it is now available as a FREE e-book from the IAS website.

Minsaw™ MinSaw has been updated numerous times, but now it’s in its best formula ever. MinSaw provides all of these proven hair growth and protectors in its latest formula: • Minoxidil: Perhaps the best known agent to help stimulate hair growth, which it does by increasing nitric oxide promotion in the root of the hair. In doing so it delivers more nutrition for the hair to grow faster. MinSaw has the most potent amount of minoxidil at 8%.

• Vitamin C: Helps stimulate hair growth and ‘clean’ the root bulb. MinSaw contains the active form of L-ascorbic acid.

• Saw Palmetto: This herb helps to block the damaging effects of DHT, a known hair growth restrictor.

• Resveratrol: The remarkable protective agent found in red grape skins has recently been noted to help induce hair thickness.

• Melatonin: This has been documented and patented to help prevent hair loss.

• Retinolic acid (also known as tretinoin). This super high strength vitamin A improves skin condition by enhancing blood flow to the skin. In the same way, this ingredient

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improves the blood supply around the hair root, helping it to be stronger and healthier.

Just apply a small amount of MinSaw daily to the scalp and see the results for yourself in a few weeks time. Use it in combination with the Scalproller to improve uptake into the scalp.

MSH2-Pro™ MSH2 is the abbreviation for melanocyte stimulating hormone (type II). This hormone has a direct effect on tanning the skin and if used regularly will darken skin- even without exposure to the sun. In addition, MSH has been noted to enhance libido and suppress the desire to eat.

NOTE: MSH use should not exceed 2-sprays per day and must not be used by persons with hypertension, (high blood pressure).

Naltrexone The results of low dose naltrexone, (widely known as LDN) therapy have been remarkable. Originally, the use of naltrexone was in the management of dependence on opioid and alcohol. But it was Dr. Bernard Bihari in the 1980’s who first used low dose naltrexone for the treatment of HIV and then for a number of other autoimmune diseases such as multiple sclerosis, Crohn’s disease and many immunological related diseases. Many MS patients have reported an improved quality of life. A leading study has established that by maintaining regular nightly LDN, less than 1% of the MS sufferers experience fresh MS attacks. IAS supplies the LDN dose of 4.5 mg.

UPDATE: Oxy-Pro™ is a new nasal spray version of oxytocin (delivering 10 IU per spray) in addition to our 20 IU sublingual trouches (Oxy-Sub™).

Peptide Bioregulators These are the very latest technology from Professor Khavinson in Russia. They utilise highly specific peptides extracted from Danish bovine sources.

These peptides have been shown to be a short-cut to protein synthesis by activating directly with their receptive genes.

Therefore their action is to ‘reinvigorate’ their respective gland/ organ, to induce their biological reserve and essentially rejuvenate their processes.

1.Bobothyrk® is the peptide for the parathyroid.

2.Bonomarlot® is the peptide for the bone marrow.

3.Cerluten® is the peptide for the central nervous system (brain).

4.Chelohart® is the peptide for the heart.

5.Chitomur® is the peptide for the bladder.

6.Endoluten® is the peptide for the pineal.

7.Glandokort® is the peptide for the adrenal glands.

8.Gotratix® is the peptide for the muscles.

9.Libidon® is the peptide for the prostate gland.

10.Pielotax® is the peptide for the kidneys.

11.Sigumir® is the peptide for the cartilage.

12.Stamakort® is the peptide for the stomach.

13.Suprefort® is the peptide for the pancreas.

14.Svetinorm® is the peptide for the liver.

15.Taxorest® is the peptide for the lungs.

Oxytocin (Oxy-Pro™)

16.Testoluten® is the peptide for the testes.

17.Thyreogen® is the peptide for the thyroid.

18.Ventfort® is the peptide for the blood vessels.

Oxytocin is a hormone produced in the hypothalamus and secreted into the blood by the pituitary gland.

19.Visoluten® is the peptide for the eye retina.

20.Vladonix® is the peptide for the thymus.

21.Zhenoluten® is the peptide for the ovaries.

Oxytocin has been described in detail in Dr. Thierry Hertoghe’s latest book- Passion, Sex and Adventure, the oxytocin story.

Oxytocin has pain curbing abilities and could be efficacious in fibromyalgia. Other studies are highlighting that oxytocin 28

could be efficacious in the treatment of autism and even schizophrenias. But it is perhaps its ability to enhance bonding between partners that is likely to attract most attention. Oxytocin increases ejaculate in the male and has significant libido enhancement effects in females, including the inducement of multiple orgasms. We have worked alongside Dr. Hertoghe to create a practical and efficacious sublingual trouche (a gel like tablet). Typical doses are 5 to 20 IU. (The square troches can be cut in half from corner to corner easily).

UPDATE: The recommended course is to start at 2 capsules

a day for 30-days (total 60 capsules). Afterward the course can be repeated at 2 capsules a day for 10-days (total 20 capsules) each quarter. Thus, after the initial intensive course all that is required are 4 boxes a year.

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Piracetam (Nootropil®; also see Anacervix®) Piracetam was the very first nootropic, (commonly called smart drugs) to be developed. Despite being one of the very first products that IAS offered when we went online in 1991, it remains one of our best selling products today! Why? Because it is a very beneficial memory agent that has a great safety record, with very few side effects. Plus, it is cost effective. Piracetam has been shown to be safer than salt. This may be because it has a very small impact upon brain chemical levels and helps to improve electrical communication across the brain’s corpus callosum.

The corpus callosum is the bundle of nerves that separates the two hemispheres of the brain.

In medical terms piracetam is used to improve short term memory and to treat a wide variety of senile dementias as well as autism and Down’s syndrome and can also assist with travel and altitude sickness. Note: IAS offers the original UCB brand called Nootropil which is available in tablet and liquid form.

The liquid form was specifically designed for children (it is sweetened with saccharin), but its advantages include being able to titrate low doses (if required) and also aid any person who has difficulty swallowing tablets.

NEW: A great value generic piracetam is now available under the name of Pira-Pro™.

PQQ (pyroloquinoline quinone) PQQ is the most newly discovered vitamin. In more than 200 studies it has been shown to improve overall energy levels, cognitive function and memory, reduce mitochondrial degradation and increase skin elasticity. Furthermore, it acts as a neuro and cardio protectant and helps to enhance nerve growth.

Progesterone Progesterone is often the ‘missing’ hormone in the treatment of female menopause. What we mean by this is that whilst estrogen treatments, (see Esnatri™ for details) are often considered as a primary replacement hormone for women, progesterone is often forgotten about.

The best known action of progesterone is its ability to help build bone mass. Progesterone levels fall rapidly in menopause and contribute to osteoporosis. Progesterone is strongly advocated to be taken in combination with any estrogen replacement program.

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UPDATE: Our progesterone strength is Pharma grade. At 5% it is twice the dose that is found in US health food stores.

Progesterone levels decline in women with age; in some cases progesterone levels are undetectable!

We recommend one of Dr. Hertoghe’s hormone handbooks for further information about progesterone.

Releasing-Pro® Releasing-Pro is a unique nasal spray that is designed to carry GHRP-6 into the bloodstream. GHRP-6 is an analogue of Ghrelin that has been shown to have significant enhancement effects on IGF-1 levels.

Retin-A®

(Retirides®)

Retin-A contains retinolic acid, a pure form of vitamin A that enhances blood supply to the skin’s surface and transforms the thicker, tougher skin into more youthful looking, elastic and fresher skin. Retin-A is the cream of choice for cosmetic surgeons to speed up the wound healing of cosmetic surgery and scarring etc.

UPDATE: We now also supply the new Retin-A® micro-gel

which is designed to sit on the skin surface and release slowly.

Sermorelin

(Serm-Pro™)

Sermorelin is a breakthrough development in the field of growth hormone (GH) replacement. Sermorelin is the bioidentical molecule used by the pituitary gland to stimulate the production and release of GH into the bloodstream. Sermorelin is not GH; GH is a complicated molecule consisting of 191 amino acids. Sermorelin is a chain of 29 amino acids. Importantly it is the first 29 amino acids of GH, the part responsible for activation. This is what makes sermorelin stand head and shoulders over all previous agonists of GH. Sermorelin is GH site-specific and therefore very effective. What is more, sermorelin has a negative feedback loop (unlike GH itself), so the issues of overdosing and safety associated with injections of GH are minimized/ completely avoided. Sermorelin is stable at room temperature and efficacious when used sublingually.

These are additional factors that favor sermorelin as the next generation of GH activators. We are excited to introduce this sublingual liquid version of sermorelin which has been created

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with the close cooperation of Dr. Richard Walker of SARA (Scientific Applied Research into Aging), a world renowned antiaging expert.

UPDATE: Sermorelin is synergistic with GHRP2 or GHRP6.

TA65® TA65 contains a highly purified specialized extract of the Chinese herb astragalus. What makes this supplement totally unique is that it is the first natural substance that has been proven to act as a telomerase activator and to extend telomeres in humans (in-vivo).

Telomeres are the strands on the ends of chromosomes that shorten each time the cell divides. This is a significant part of the destructive process of aging. Animals with longer telomeres enjoy a more productive and healthier older age and appear to live longer.

TA65 production is carefully controlled by TA Sciences, who purchased the technology from the Geron Corporation.

Whilst other substances have claimed to delay the shortening of telomeres, only TA65 has been clinically proven (and published) to actually lengthen short telomeres in humans. If you want the cutting-edge of antiaging supplementation and the best possible chances for longer telomeres, then TA65 is currently your best (and indeed only) clinically proven choice.

Thyroid (Armour®; Synthroid®) A decline in the secretion of hormones from the thyroid gland (hypothyroidism) can result in poor concentration, confusion, memory problems, cold hands and feet, weight gain, menstrual problems, sleep disorders, dry skin, thinning hair and low energy levels. An underactive thyroid is also a major cause of a common painful musculoskeletal condition known as fibromyalgia. Aging often leads to hypothyroidism. One of the most famous thyroid experts, Dr. Broda Barnes, stated that as many as 40% of the adult population could be hypothyroid. Thyroid supplements come in two forms; natural supplements and synthetic supplements.

It is almost always better to use a whole-natural thyroid extract because the synthetic versions usually only comprise one of the thyroid hormones, (such as, T3 or T4), whereas, wholenatural thyroids cover a fuller spectrum of thyroid hormones (including T1, T2, T3 and T4).

For further details about thyroid we recommended one of Dr. Hertoghe’s hormone handbooks.

UPDATE: ERFA now available in value 500 tablet packs.

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TRH (Abaris™) TRH is a hypothalamic hormone (technically a tri-peptide) whose real uses and benefits are just coming to the fore, primarily after research conducted

by Dr. Walter Pierpaoli, the physician and scientist who exposed the benefits of melatonin to the world. Dr. Pierpaoli’s research suggests that TRH is a ‘master’ hormone responsible not just for helping to adjust thyroid hormones (its principle recognised role), but in helping to recorrect many imbalances throughout the body.

For example in his animal experiments TRH supplements have encouraged old animals to: •

Re-establish spermogenesis, (reversing the age-related dysfunction of their testes).

•

Correct kidney dysfunction, (a significant finding for renal issues).

•

Correct pancreatic dysfunction, (a significant finding for diabetic issues).

•

Improves many lipid profiles and aids weight loss when used over a few months.

IAS is delighted to be the first organisation in the world to offer a sublingual TRH tablet.

Vasopressin Vasopressin is a porcine extracted source for this pituitary hormone which has a number of interesting roles.

Its approved medical use is to prevent frequent urination in conditions such as diabetes insipidus. For example, men with prostate conditions can benefit by less trips in the night to urinate.

But vasopressin is also responsible for the laying down of memories in the hippocampus and it has been used to treat amnesia. In particular, it is cited by many for memory imprinting, this is the learning of new material before it is experienced. Therefore taking 1 or 2 sprays into each nostril 15-minutes before an exam, meeting or lecture etc., can induce a better detailed recall of events later.

ZeoGold Enhanced® ZeoGold Enhanced is the latest zeolite formula from world chelation and detox expert, Dr. Garry Gordon. In this new ‘enhanced’ formula Dr. Gordon has included the highest grade of zeolite for detox purposes along with the methylation agents and now added hydrogen for enhancement of energy.

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Product A-Z listing Here is an alphabetical listing of IAS stocked products. See our cross-reference list of disorders that relate to these individual products. Much more information is available from our website including full ingredient/ excipient listings, doses and side effects etc. If you need any further information or can’t find what you require, please don’t hesitate to contact us. The inside back cover has all our details.

Testimonials “IAS has shown great vision and leadership, as an organisation focused mainly on the provision of contemporary medical interventions against aging, and in also supporting the SENS Foundation’s efforts to hasten the development of much more powerful future interventions.”

Dr. Aubrey De Grey “IAS is an outstanding resource for the finest, most up-to-date news and information on healthy aging. They also offer products of the highest integrity and efficacy. In fact, IAS is the world’s greatest source (often the only source) for the most cutting edge and advanced nutrients to ensure optimum health span and maximum life span.”

Nicholas Perricone, M.D.

The following index underneath certain products means that known restrictions apply. For example: Not shipped to UK Not shipped to EU Not shipped to Japan Not shipped to Australia (or New Zealand) Not shipped to Canada Note: For use strictly by IAS private club members - IAS terms and conditions apply. All information is educational and does not replace the advice of your physician. Prescriptions are necessary where required by law; other restrictions may apply in some countries.

“IAS has a history of making throughout the world crucial, but difficultly accessible medications available to patients. IAS is one of the pioneering societies in antiaging medicine that has helped this new medical specialty move forward.”

Thierry Hertoghe, M.D. “I am a 77 year old Physician who has practiced medicine for nearly half a century.

My antiaging research has permitted me to overcome serious health problems. Everyone can do this, but it requires specialized knowledge and the highest quality products.

IAS is a vital link in my antiaging program because they continually provide both accurate information AND the high quality products we all require, if we are to achieve our maximum intended useful lifespan.”

Garry Gordon, MD, DO, MD (H) “Every adult has the right to take care of his or her own personal health as he or she chooses.

In the 20th and 21st centuries, this universal human right has been nearly obliterated by an ocean of nanny-state regulation and deliberate suppression of information by bureaucracies, with hidden and not-so-hidden agendas.

International Antiaging Systems is a beacon of useful health care information and a literal island of freedom of health care product choice in our otherwise un-free health care world.”

Jonathan Wright, M.D. See all professional and public testimonials at: www.antiaging-systems.com/content/11-testimonials

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1st Line™ (OSCN, thiocyanate)

Anacervix®

5HTP (5-hydroxy-tryptophan)

Anastrozole (Arimidex®)

1 complete kit retail $90 IAS price $79.99 Item Code: 675

5HTP-Pro™ 60x 50mg capsules retail $20 IAS price $17.99 - Item Code: 327

Acarbose

Glucobay® 30x 100mg tablets retail $30 IAS price $27.49 - Item Code: 373

Acetyl-L-Carnitine (see ATP-Boost™)

ACF228™

ACF228™ 45 capsules retail $60 IAS price $49.99 - Item Code: 621 NEW: ACF228™ Breathe-Easy 1 inhaler retail $150 IAS price $139.99 - Item Code: 810

Anacervix® 30x 420mg capsules retail $29 IAS price $24.99 - Item Code: 163

Anastrozole 28x 1mg tablets retail $149 IAS price $139.99 - Item Code: 849 Anastro-Pro™ 28x 100mcg capsules retail $39.99 IAS price $34.99 - Item Code: 779

Andro-Pro™

Andro-Pro™ 60 capsules retail $55 IAS price $49.99 - Item Code: 758

Aniracetam

Ani-Pro™ 20x 750mg capsules retail $35 IAS price $29.99 - Item Code: 777

Adenosine Triphosphate (see ATP)

Arginine (see Beyond GHS®; Nitric-Pro™), Argireline (see Crème-Pro™ Smoother), Arterial wave velocity (see Bio-Clip & Bio-Cuff)

Adrafinil

Artemisinin

Adra-Pro™ 40x 300mg capsules retail $60 IAS price $49.99 - Item Code: 775

Artem-Pro™ 90x 100mg capsules retail $25 IAS price $22.99 - Item Code: 642

Ascorbyl palmitate (see Crème-Pro™ Protector, Crème-Pro™ Smoother), Astaxanthin (see CrèmePro™ Protector), Astragalus extract (see TA65®)

Aglomelatine (see Valdoxan)

Aldosterone

Aldosterone 15x 125mcg capsules retail $105 IAS price $99.49 - Item Code: 687

Alfalfa (see Dr Gordon’s Organic Greens®), Allicin (see garlic), Alpha lipoic acid (see lipoic acid)

Aminoguanidine (pimagedine) Amino-Pro 90 x 75mg tablets retail $35 IAS price $29.99 - Item Code: 977

Aminohydroxybutyric acid (see GABOB), Aminophylline (see Crème-Pro™ Cellulite), Aminosyn (see Hair-Pro™), Amphoteric surfactants (see Nanogen® shampoo, Nanogen® conditioner)

ATP (Adenosine Triphosphate)

ATP-Boost™ 60x 20mg tablets retail $35 IAS price $29.99 - Item Code: 821 ATP-Boost™ (see ATP), Azilect® (see rasagiline)

B12 (vitamin B12) Beyond B12® 40x 2mg sublingual tablets retail $30 IAS price $29.99 - Item Code: 477 NEW: Cromatonbic® 8x1mg i.m.ampoules retail price $20 IAS price $17.49 - Item Code: 951 Barley grass (see Dr Gordon’s Organic Greens®), BCI (see Beyond Chelation Improved®)

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B-Cure® laser 1 Unit

Bio-CUFF™

BEC5 Curaderm®

Bio-En’R-Gy C®

Beetroot (see Neo40®)

Bioflavonoids (see Wobenzym®), Biological age measurement (see Bio-CLIP™, PulmoLife®), Bioperine (see Bio-En’R-Gy®), Biotin (see Beyond B12®; Beyond Chelation Improved®, HRT Plus®; BCI; Nitric-Pro™), Blood oxygenation measurement (see Bio-CLIP™), Blood pressure measurement (see Bio-CUFF™), Blueberry extracts (see Andro-Pro™)

B-Cure® laser 1 Unit retail $795 IAS price $749.99 - Item Code: 850

BEC5 Curaderm® 20ml tube cream retail $140 IAS price $129.99 - Item Code: 403

Benfotiamine

Milgamma Mono® 30x 50mg tablets retail $25 IAS price $21.49 - Item Code: 273

Benzoic acid (see Gerovital®), Beta alistine (see L-carnosine), Beta glucan (see Beyond Chelation Improved®, Nanogen® serum), Betaine (see TMG), Beta sitosterol (see Beyond Chelation Improved®), Beyond Any Multiple® (see Beyond Chelation Improved®)

Beyond Chelation Improved® (BCI) Beyond Chelation Improved® 30 sachets retail $80 IAS price $79.99 - Item Code: 351

Beyond Clean® v2 (Calcium EDTA & Zeolite)

NEW: Beyond Clean® v2 32 oz. bath salts retail $70 IAS price $69.99 - Item Code: 881

Beyond Fiber®

Beyond Fiber® 504 grams powder retail $50 IAS price $49.99 - Item Code: 436

bFGF (see Hair-Pro™), BHT (butylhydroxytoluene, see ACF228™)

Bio-CLIP™

complete kit retail $1300 IAS price $1299.99 - Item Code: 653

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Bio-CUFF® one complete kit retail $150 IAS price $124.99 - Item Code: 715

Bio En’R-Gy C® 200 grams powder retail $60 IAS price $59.99 - Item Code: 591

Boluoke® (Lumbrokinase)

NEW: Boluoke® 60 capsules retail price $108 IAS price $94.99 - Item Code: 839

Bone-Pro2™

NEW: Bone-Pro2™ 60 capsules retail $39 IAS price $32.99 - Item Code: 870

Borate (see Andro-Pro™, Can-C™), Boron (see Andro-Pro™, Beyond Chelation Improved®, BCI)

Bromocriptine

Parlodel® 30x 2.5mg tablets retail $29 IAS price $24.99 - Item Code: 58

Bromelain (see Digestif®, Wobenzym®), Buxamin (see GABOB), Calcium (see Bone-Pro™, BCI, Nitric-Pro™)

Cabergoline (Dostinex®)

Dostinex® 8x 0.5mg tablets retail $99 IAS price $92.49 - Item Code: 612

Caffeine (see Crème-Pro™ Cellulite), Calcium (see Bone-Pro™, Beyond Chelation Improved®, Nitric-Pro™)

Can-C™ eye-drops

Can-C™ 2x 5ml vials retail $45 IAS price $39.99 - Item Code: 456

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Can-C™ Plus

Can-C Plus™ 90 capsules retail $40 IAS price $34.99 - Item Code: 629

ubiquinol, biquinone)

NEW: CoQ10SRTM 30 x 100mg slow release capsules retail $30 IAS price $25.99 - Item Code: 824

Carboxymethylcellulose (see Can-C™) , Carbidopa (see Sinemet®), Carnosine (L-carnosine, see ACF228™, Can-C™, Can-C Plus™, L-carnosine), Catalase (see ACF228™)

Copper (see Beyond Chelation Improved®), Cortisol (cortisone, see Fludrocortisone, hydrocortisone), Cranberry extracts (see Andro-Pro™)

Centrophenoxine (meclofenoxane)

Crème-Pro™ Cellulite

Cerebrolysin®

Crème-Pro™ Moisturizer

Chlorella (see Dr Gordon’s Organic Greens®), Choline (see Beyond Chelation Improved®, centrophenoxine, krill), Chromium (see Beyond Chelation Improved®), Chromium polynicotinate (see ACF228™)

Crème-Pro™ Protector

Cialis® (tadalafil)

Crème-Pro™ Smoother

Cialis® 4x 20mg tablets retail $90 IAS price $84.99 - Item Code: 296

Crème-Pro™ Smoother 30ml pump cream retail $69 IAS price $59.99 - Item Code: 831

Ciproxin® (ciprofloxacin)

Cresote bush (see ACF228®, Digestif®)

Centro-Pro™ 60x 250mg tablets retail $29.99 IAS price $24.99 - Item Code: 243

Cerebrolysin® 5x 5ml i.m. ampoules retail $99 IAS price $89.99 - Item Code: 595

Ciproxin® 14x 500mg tablets retail $35 IAS price $32.49 - Item Code: 948

Citrus bioflavonoids (see Beyond Chelation Improved®), Cocos nucifera oil (see Nanogen® conditioner)

Crème-Pro™ Cellulite 30ml pump cream retail $34 IAS price $29.99 - Item Code: 828

Crème-Pro™ Moisturizer 30ml pump cream retail $44 IAS price $39.99 - Item Code: 829

Crème-Pro™ Protector 30ml pump cream retail $59 IAS price $49.99 - Item Code: 830

CurcuminSR™ (turmeric extract)

NEW: CurcuminSR™ (slow release) 30x 125mg capsules retail $25 IAS price $21.49 - Item Code: 841

Cycloastragenol (see TA65®), Cyclodextrin (see CoQ10SR™), Cyprenil® (see deprenyl)

Cobalt chloride

Cobalt 100x 200mcg tablets retail $55 IAS price $49.99 - Item Code: 646

D3 (vitamin D)

Coenzyme Q10 (see CoQ10)

D3-5000™ 100x 5000 IU capsules retail $20 IAS price $14.99 - Item Code: 843

Colchicine (Colcrys®)

NEW: D3-Pro2™ 12x 50,000 IU capsules retail $30 IAS price $24.99 - Item Code: 842

NEW: Colchicine 40x 1mg tablets retail $24 IAS price $19.99 - Item Code: 835

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CoQ10SRTM (Coenzyme Q10,

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Deprenyl (selegiline)

Jumex® 50x 5mg tablets retail $65 IAS price $54.99 - Item Code: 35

Dr. Gordon’s Organic Greens Organic best of greens® 10 oz. bottle powder retail $35 IAS price $34.99 - Item Code: 688

Dep-Pro™ 20ml/ 300mg liquid (HCL) bottle retail $90 IAS price $84.99 Item Code: 746

Dutasteride

Dercos® (aminexil)

Avodart® 30x 0.5mg tablets retail $89 IAS price $82.49 - Item Code: 276

Dercos® 200ml bottle shampoo retail $29 IAS price $24.99 - Item Code: 17

Desmopressin (also see vasopressin)

Minurin® 2.5ml nasal spray retail $39 IAS price $34.99 - Item Code: 229

DHA (docosahexaenoic acid, see krill), Diapid® (see vasopressin)

Digestif™

Digestif® 60 capsules retail $20 IAS price $16.99 Item Code: 626

Di-IndolylMethane (DIM, see ACF228™, DIM-Pro™), DIM (see ACF228™, DIM-Pro™), Dimethicone (see Nanogen®)

DIM-Pro2™

Ebixa (see Memantine) EDTA (ethylene diamine tetraacetic acid, see Beyond Chelation Improved®, Beyond Clean®, Beyond Fiber®), Eldepryl® (see deprenyl), EPA (eicosapentaenoic acid, see krill), Ergoloid mesylate (see hydergine, nicergoline)

Esnatri™ cream (bio-identical triple estrogen cream)

Esnatri™ 50ml 100mg cream retail $55 IAS price $49.99 - Item Code: 25 Essential Daily Defence® (see Beyond Chelation Improved®), Estradiol (see Esnatri™), Estriol (see Esnatri™), Estrone (see Esnatri™)

Finesteride (also see Hair-Pro™) Finesteride generic 28x 5mg tablets retail $40 IAS price $37.49 - Item Code: 749

NEW: DIM-Pro2 ™ 100 capsules retail $50 IAS price $44.99 - Item Code: 844

Proscar® 15x 5mg tablets retail $45 IAS price $39.99 - Item Code: 67

DMAE (dimethylaminoethanol, see centrophenoxine, Crème-Pro™ Smoother), DMSA (dimercaptosuccinic acid, see ACF228™), DMSO (Dimethyl sulfoxide, see laetrile), Docosahexaenoic acid (see DHA), Dostinex® (see cabergoline)

Florinef® (see Fludrocortisone)

Doxycycline

Doxycycline 8x 100mg capsules retail $29 IAS price $24.99 - Item Code: 164

D-pantethine (see Can-C Plus™), D-panthenol (see Nanogen® conditioner)

Fluconazole (Diflucan)

Loitin® 7x 50mg capsules retail $39 IAS price $34.99 - Item Code: 307

Folic acid (folate, see ACF228™, Beyond Chelation Improved®, Beyond B12®; Dim-Pro2™, HRT Plus®, Lithium-Pro™, Nitric-Pro™), Forced Expiry Volume- Lungs (see PulmoLife®)

Fludrocortisone

Fludro-Pro™ 100x 20mcg tablets retail $24 IAS price $19.99 - Item Code: 759

36

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36

Fructoborate (see Andro-Pro™), GABA (gamma-aminohydroxybutyric acid, see Gamalate B6®, picamilone)

Glutathione (also see ACF228™

Gabapentin

Advanced Cellular Glutathione® 2 oz. spray retail $45 IAS price $42.49 - Item Code: 832

GABOB (also see Gamalate®)

Gamibetal® 20x 500mg tablets retail $39 IAS price $34.99 - Item Code: 402

Glycerine (glycerin, see Can-C™), Glycosides (see BEC5 Curaderm®), Grape seed extracts (see Beyond Chelation Improved®, Resveratrol-Pro™), Green tea extracts (see Resveratrol-Pro™), Growth hormone (see HGH)

Galantamine (Reminyl®)

Hair-Pro™

Gamalate®

Hawthorne Berry (crataegus, see Beyond Chelation Improved®, Neo40®), Heart rate measurement (see Bio-CLIP™, Bio-CUFF™)

NEW: Neurontin® 100x 300mg capsules retail $49 IAS price $44.99 - Item Code: 875

Galantamine Pro 30x 8mg tablets retail $79 IAS price $69.99 - Item Code: 825

Gamalate B6® 60x 250mg tablets retail $24 IAS price $19.99 - Item Code: 27

Garlic (see see Beyond Chelation Improved®)

Gengigel® mouthwash

Gengigel® 150ml bottle liquid retail $24 IAS price $19.99 - Item Code: 550

Breathe Easy)

NEW: Hair-Pro™ 2 oz. spray bottle retail $180 IAS price $169.99 - Item Code: 765

HemaGel®

NEW: HemaGel® 5 gram tube cream retail $20 IAS price $17.99 - Item Code: 820

Genotropin® (see HGH)

HGH (human growth hormone, somatropin, see IGF-1, Sermorelin, Beyond GHS®, GABOB, GHRP2, GHRP6), Humatrope® (see HGH), Hyaluronic acid (see Hyaluronan, Crème-Pro™ Protector, Gengigel®, Hair-Pro™, Novisyn®)

Gerovital-H3®

HRT Plus®(pueraria mirifica)

Gerovital-H3® 25x 100mg tablets retail $35 IAS price $29.99 - Item Code: 29

HyderPro™ (ergoloid mesylate)

Gerovital-H3® 5x 5ml ampoules retail $59 IAS price $49.99 - Item Code: 258

HRT Plus® 60 tablets retail $50 IAS price $49.99 - Item Code: 496

GH3-Pro™ 60x 100mg tablets retail $25 IAS price $17.49 - Item Code: 360

Hydergine® 30x 4.5mg capsules retail $35 IAS price $39.99 - Item Code: 952

GH (growth hormone, see HGH), Ginkgo biloba (see Beyond Chelation Improved®), Glucophage (see metformin)

Hydrocortisone

GHRP2

NEW: GHRP2-Pro™ 120ml 120mg liquid bottle retail $175 IAS price $159.99 - Item Code: 872

Hydro-Pro® 100x 5mg capsules retail $35 IAS price $29.99 - Item Code: 760

Hydrogen (see Zeogold Enhanced®)

GHRP6 (see Releasing-Pro™) 36

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37

Idebenone (also see Crème-Pro™ Protector)

NEW: Ideb-Pro™ 60x 30mg tablets retail $29 IAS price $24.99 - Item Code: 492

Lithium (orotate)

NEW: Lith-Pro™ 100x5mg capsules retail $30 IAS price $24.99 - Item Code: 906

IGF-1 (insulin like growth factor, see Hair-Pro™ also see Releasing-Pro™), Indol-3-Carbinol (I3C, see DIM)

L-methione (see ACF228™; Can-C Plus™), L-proline (see Nitric-Pro™), Lucidril® (see centrophenoxine), Lumbrokinase (see Boluoke®), Lupine extract (see Nanogen® serum)

Injection packs

L-tryptophan

Intramuscular kit 30x pack retail $30 IAS price $27.49 - Item Code: 439

L-Tryp-Pro™ 50x 500mg capsules retail $20 IAS price $17.49 - Item Code: 666

Subcutaneous kit 30x pack retail $30 IAS price $27.49 - Item Code: 438

Lysine (see Nitric-Pro™)

Inosine (see Beyond GHS®), Inositol (see Beyond Chelation Improved®), Iodide (see ACF228™), Iodine (see ACF228™, Beyond Chelation Improved®), Isoflavonoids (see HRT Plus®), Ixel® (see milnacipran), Jerusalem artichoke (see Beyond Fiber®), Joint-Pro™ (see Hyaluronan), Jumex® (see deprenyl), Ketoconazole (see Nizoral®)

Longevity Maca 175 grams powder retail $40 IAS price $39.99 - Item Code: 851

Krill

Krill 60x 500mg gel capsules retail $45 IAS price $39.99 - Item Code: 584

Laetrile (amygdalin; VitaB17®)

Maca (lepidium meyenii walp) Magnesium (see Andro-Pro™, Beyond Chelation Improved®, Bone-Pro2™, Digestif®, Gamalate B6®, Nitric-Pro™), Malic acid (see Beyond Chelation Improved®), Manganese (see Beyond Chelation Improved®), Mastic (see Digestif®), Meclofenoxane (see centrophenoxine)

Melatonin (Melatonin Zn Se®) MZS™ 60x 3mg tablets retail $30 IAS price $19.99 - Item Code: 701

Vita-B17 cream 50ml 1% retail $99 IAS price $89.99 - Item Code: 763

Note: The UK can order in Pounds Sterling at: www.melatoninznse.com

L-arginine (see arginine), Lasers (see B-Cure®, Vie-Light®)

Memantine (Namenda®; Ebixa®)

L-carnosine (also see ACF228™; Can-C™; Can-C Plus™)

Carnosine 60x 250mg capsules retail $30 IAS price $24.49 - Item Code: 784 L-citrulline (see Neo40®), L-cysteine (see Nanogen® conditioner), L-dopa (see Sinemet®), Lecithin (see Crème-Pro™ Cellulite), Levodopa (see Sinemet™), L-histidine (see Can-C Plus™), Lemon grass (see Dr Gordon’s Organic Greens®), Licorice (see Beyond GHS®, Digestif®), Lipoic acid (alpha version see Beyond Chelation Improved®; R-version see ATP-Boost™)

Memantine-Pro™ 42x 10mg capsules retail $105 IAS price $89.99 - Item Code: 826

Melanocyte stimulating hormone (see MSH)

Metformin (Glucophage®) Dianben® 50x 850mg tablets retail $29 IAS price $24.99 - Item Code: 382 Metforal® 50x 500mg tablets retail $25 IAS price $22.99 - Item Code: 42 NEW: Metformin SR® 56x 500mg tablets retail $30 IAS price $27.99 - Item Code: 874 Methione (see Beyond Chelation Improved®), Milk Protein (see Bone-Pro2™)

38

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38

Nanogen® serum

Milnacipran (Savella®)

Ixel® 56x 50mg tablets retail $80 IAS price $74.99 - Item Code: 400

Minerals (general, see Quinton®), Minoxidil (see MinSaw™)

Nanogen® 30ml serum dropper MEN retail $55 IAS price $54.99 - Item Code: 890 Nanogen® 30ml serum dropper WOMEN retail $55 IAS price $54.99 - Item Code: 891

Nanogen® shampoo

MinSaw™

MinSaw™ 30ml bottle topical liquid retail $45 IAS price $39.99 - Item Code: 728

Miroestrol (see HRT Plus®), Mito-Pro™ (see ATP-Boost™)

Moclobemide (Manerix®) Moclamine® 30x 150mg tablets retail $35 IAS price $29.99 - Item Code: 39

Modafinil (also see adrafinil)

Nanogen® 240ml tube shampoo MEN retail $18 IAS price $17.99 - Item Code: 888 Nanogen® 240ml tube shampoo WOMEN retail $18 IAS price $17.99 - Item Code: 889

Needles (see injection packs), Neurontin® (see Gabapentin), Nettle root extract (see Prostate-Pro™)

Neo40®

Neo40 Daily® 30x lozenges retail $60 IAS price $59.99 - Item Code: 790

Alertec® 30x 100mg tablets retail $180 IAS price $169.99

Nettle root extract (see Prostate-Pro™)

Modiodal® 30x 100mg tablets retail $170 IAS price $159.99

Neydent toothpaste

Provigil® 30x 100mg tablets retail $200 IAS price $189.99

Neydent toothpaste 50ml tube retail $18 IAS price $15.99 - Item Code: 118

Niacin (nicotinate, niacinamide, see vitamin B3) Note: This product can be ordered via:

www.modafinil-store.com

Nicergoline

Molybdenum (see Beyond Chelation Improved®), MSM (methylsulfonomethane, see Beyond Chelation Improved®, Bio-En’R-Gy®, Nitric-Pro™), N-acetylcarnosine (see Can-C™), N-acetylcysteine (see ACF228™, Can-C™ Plus), NADH (Nicotinamide adenine dinucleotide, see Crème-Pro™ Moisturizer, PQQ)

Nitric Oxide Saliva Test Strips

MSH (melanocyte stimulating hormone) NEW: MSH2-Pro™ 5ml 500IU nasal spray retail $79 IAS price $69.99 - Item Code: 905

Naltrexone (Navcol®)

Naltrex-Pro™ 30x 4.5mg capsules retail $70 IAS price $59.99 - Item Code: 637

Namenda® (see Memantine)

Nanogen® conditioner

Nanogen® 240ml tube conditioner MEN retail $20 IAS price $19.99 - Item Code: 886 Nanogen® 240ml tube conditioner WOMEN retail $20 IAS price $19.99 - Item Code: 887

38

Sermion® 50x 10mg tablets retail $50 IAS price $47.49 - Item Code: 489

Neo40® 10 saliva strips $25 IAS price $24.99 Item Code: 866

Nitric-Pro™

Nitric-Pro™ 225 grams powder retail $45 IAS price $39.49 - Item Code: 792

Nizoral® shampoo (2% ketoconazole) Nizoral® 60ml bottle shampoo retail $19 IAS price $14.99 - Item Code: 437

Novisyn® Hyaluronic Acid Novisyn® Hyaluronic Acid 30 x 5ml liquid sachets retail $30 IAS price $29.49 - Item Code: 900

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39

Nordihydroguaiaretic acid (NDGA, see ACF228™, Digestif®), Norditropin® (see HGH), Oat grass (see Dr Gordon’s Organic Greens®), Omega 3 (see Beyond Chelation Improved®, krill), Omega 6 (linoleic acid, GLA, see Beyond Chelation Improved®, krill), Omega 9 (oleic acid, see Beyond Chelation Improved®, krill), Oxythiocynate (OCSN, thiocynates, see 1st Line™)

Oxytocin

Oxy-Sub™ 24x 20 IU sublingual troches retail $85 IAS price $79.99 - Item Code: 660 Oxy-Pro® 5ml 500 IU nasal spray retail $65 IAS price $59.99 - Item Code: 823

PABA (para-aminobenzoic acid, see Beyond Chelation Improved®, Gerovital®), Palmitate (see Beyond Chelation Improved®), Pancreatin (see Wobenzym®), Panthenol (pantothenic acid, see vitamin B5), Papain (see Beyond Chelation Improved®, Wobenzym®)

PEMF (Pulsed electronic magnetic field) Please contact us for the range of professional equipment currently available. Further details are available at www.pemf-therapy.eu

Penicillin (Penilevel®)

NEW: Kidneys (Pielotak®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 869 NEW: Liver (Svetinorm®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 894 NEW: Lungs (Taxorest®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 959 NEW: Muscle (Gotratix®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 978 NEW: Parathyroid (Bobothyrk®) 20x 200mg capsules retail $90 IAS price $79.99 NEW: Pancreas (Suprefort®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 892 NEW: Pineal (Endoluten®) 20x 200mg capsules retail $110 IAS price $99.99 - Item Code: 884 NEW: Prostate (Libidon®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 854

Penilevel® 20x 250mg sachets powder retail $34 IAS price $29.99 - Item Code: 952

NEW: Testes (Testoluten®) 20 x 200mg capsules retail $90 IAS price $79.99 - Item Code: 855

Pentavita (see Nanogen®)

NEW: Thyroid (Thyreogen®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 883

Peptide Bioregulators NEW: Adrenals (Glandokort®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 853 NEW: Blood vessels (Ventfort®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 868

NEW: Stomach (Stamacort®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 896 NEW: Heart (Cheloheart®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 898

NEW: Bone Marrow (Bonomarlot®) 20x 200mg capsules retail $90 IAS price $79.99

NEW: Bladder (Chitomur®) 20 x 200mg capsules retail $90 IAS price $79.99 - Item Code: 897

NEW: Brain (Cerluten®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 867

NEW: Ovaries (Zhenoluten®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 899

NEW: Cartilage (Sigumir®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 893

NEW: Thymus (Vladonix®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 882

NEW: Eyesight (Visoluten®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 856 40

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40

Phenytoin (Dilantin®, Epanutin®) Phen-Pro™ 28x 25mg capsules retail $25 IAS price $19.99 - Item Code: 786

Phosphatidylcholine (see Beyond Chelation Improved®, Crème-Pro™ Cellulite), Phosphatidylserine (see Beyond Chelation Improved®), Phospholipids (see krill), Phosphorous (see Nitric-Pro™)

PregPro™ 50x 100mg capsules retail $25 IAS price $21.49 - Item Code: 335

Procaine (Novocain®, see Gerovital®, Crème-Pro™ Moisturizer)

Progesterone

Progesterone 50ml 2.5 grams (5%) cream retail $35 IAS price $29.99 - Item Code: 789

Picamilone

Pic-Pro™ 60x 50mg tablets retail $25 IAS price $19.99 - Item Code: 184

Propranolol (Inderal®)

Inderal® 30x 40mg tablets retail $25 IAS price $19.99 - Item Code: 34

Pimagidine (see aminoguanidine)

Piracetam (also see Anacervix®) Nootropil® 20 grams 100ml liquid retail $25 IAS price $21.49 - Item Code: 50 Nootropil® 60x 800mg tablets retail $30 IAS price $27.99 - Item Code: 205 Pira-Pro™ 100x 800mg tablets retail $24 IAS price $17.99 - Item Code: 873 Polyphenols (see grape seed extract), Pomegranate extracts (see Andro-Pro™), Potassium (see Beyond Chelation Improved®, Gerovital®), Potassium iodide (see ACF228™), Potassium iodine (see ACF228™)

PQQ (pyroloquinoline quinone)

NEW: PQQ-Pro™ 30x 20mg capsules retail $40 IAS price $35.99 - Item Code: 837

Prostate-Pro2™

NEW: Prostate-Pro2™ 60 capsules retail $35 IAS price $29.99 - Item Code: 871

Pueraria mirifica (see HRT Plus®), Pulsed electronic magnetic field (see PEMF) Pulsed magnetic therapy (PMT, see PEMF), Pygeum africanum (see Nanogen®, Prostate-Pro2™)

Pyridoxamine

Pyridox-Pro™ 60x 50mg tablets retail $39 IAS price $32.49 - Item Code: 449

Pyritinol

Cerbon 6® 60x 100mg tablets retail $29 IAS price $24.99 - Item Code: 167

Pyroloquinoline quinone (see PQQ), Quercetin (see Digestif®, Resveratrol-Pro™)

Pueraria mirifica (see HRT Plus®)

PulmoLife® (FVC biological age)

PulmoLife®1 Spirometer + 4 tubes retail $160 IAS price $139.99 - Item Code: 781

Quinton®

PulmoLife®25 additional tubes retail $25 IAS price $19.99 - Item Code: 782

Isotonic® 24 oral ampoules retail $40 IAS price $34.99 - Item Code: 681 Hypertonic® 24 oral ampoules retail $40 IAS price $34.99 - Item Code: 682

Pramiracetam

Rasagiline

PramPro™ 40x 300mg tablets retail $60 IAS price $49.99 - Item Code: 451

40

Pregnenolone

NEW: Rasagiline-Pro™ 30x 1mg capsules retail $95 IAS price $89.99 - Item Code: 827

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41

Reboxetine (Davedax®)

Scalproller®

Red algae (carrageenan, see Beyond Chelation Improved®), Red clover herb extract (see Prostate-Pro2™), Red yeast (see Beyond Chelation Improved®)

Selepryl® (see deprenyl), Selegiline (see deprenyl), Selenium (see ACF228™, Beyond Chelation Improved®, Dim-Pro2™, MZS™, Prostate-Pro2™, thymus)

Edronax® 60x 4mg tablets retail $70 IAS price $64.99 - Item Code: 22

Releasing-Pro™ (GHRP6)

Sermorelin

NEW: Releasing-Pro™ 5ml 500IU nasal spray retail $89 IAS price $79.99 - Item Code: 904

Sermo-Pro® 30ml/ 30mg liquid bottle retail $215 IAS price $199.99 Item Code: 714

Reminyl® (see Galantamine), Resveratrol (see ACF228™, Beyond Chelation Improved®, Crème-Pro™ Protector, MinSaw™, Resveratrol-Pro™)

Shave grass (see Dr Gordon’s Organic Greens®), Silicon/ Silica (see Beyond Chelation Improved®; Nanogen™, Wobenzym®)

Resveratrol-Pro™

Silver protein (ACS®)

Resveratrol-Pro™ 60 capsules retail $30 IAS price $24.99 - Item Code: 647

Retin-A®

Retirides® 30ml 0.025% cream retail $39 IAS price $29.99 - Item Code: 254 Retirides® 30ml 0.050% cream retail $49 IAS price $39.99 - Item Code: 764 Retirides® 30ml 0.100% cream retail $59 IAS price $49.99 - Item Code: 74 Retin-A® 20ml 0.100% micro-gel retail $80 IAS price $74.99 - Item Code: 744

Retinolic acid (tretinoin, see MinSaw™, Retin-A®), Ribonucleic acids (RNA, see Cerebrolysin®, NeyDent®), Ribose (see Bio-En’R-Gy®), Rice bran husks (see Beyond Fiber®), R-lipoic acid (see ATP-Boost™)

Roxithromycin

Rulid® 10x 150mg tablets retail $35 IAS price $29.49 - Item Code: 635

Rutin (see Wobenzym®), Saizen® (see HGH), Salicylic acid (see BEC5 Curaderm®, Nanogen® shampoo)

SAMe (S-Adenosyl-L-Methionine) SAMYR® 20x 400mg enteric-coated tablets retail $69 IAS price $64.99 - Item Code: 231 Saw palmetto (Serena repens, see MinSaw™; Nanogen®, Prostate-Pro2™)

42

Scalproller® 0.3mm roller kit retail $75 IAS price $69.99 - Item Code: 762

Advanced Cellular Silver 200® 2 oz. spray retail $39 IAS price $34.99 - Item Code: 596

Sinemet® (l-dopa & carbidopa)

Sinemet® 50x 100mg tablets retail $59 IAS price $54.99 - Item Code: 81

Solasodine glycosides (see BEC5 Curaderm®), Somatomedin C (see IGF-1), Somatropin (see HGH), Spirulina (see Dr Gordon’s Organic Greens®)

Stablon® (tianeptine)

Stablon® 60x 12.5mg tablets retail $69 IAS price $62.49 - Item Code: 748

Stevia (see Dr Gordon’s Organic Greens®), Superoxide dismutase (SOD, see Nanogen® serum), Syringes (see injection packs)

TA65®

TA65® 30 capsules IAS price $218.99 - Item Code: 755 TA65® 90 capsules IAS price $599.99 - Item Code: 754

Tamanu Tamanu 50ml bottle oil retail $29 IAS price $24.99 - Item Code: 724

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42

Telomeres/ telomerase (see TA65®), Temple viper venom (synthetic, see Crème-Pro™ Smoother)

Tetracycline

Ambramicina® 16x 250mg tablets retail $25 IAS price $22.49 - Item Code: 143

Thymus (also see peptide bioregulator)

Thym-Uvocal® 90x 200mg capsules retail $115 IAS price $99.99 - Item Code: 691

Thyroid (also see peptide bioregulator)

NEW: Nature® 1½ grain 100x 90mg tablets retail $75 IAS price $69.99 - Item Code: 901 Nature® 2 grain 100x 120mg tablets retail $85 IAS price $79.99 - Item Code: 460

Our synthetic thyroids include: Eutirox® (T4) 84x 100mcg tablets retail $34 IAS price $27.49 - Item Code: 662 NEW: T3Pro™ (T3) 100x 20mcg tablets retail $tbc IAS price $29.99 - Item Code: 960

Our natural thyroids include: Armour® 100x 15mg tablets retail $75 IAS price $69.99 - Item Code: 411 Armour® 100x 30mg tablets retail $85 IAS price $79.99 - Item Code: 468 Armour® 100x 60mg tablets retail $95 IAS price $89.99 - Item Code: 7 Armour® 100x 90mg tablets retail $135 IAS price $129.99 - Item Code: 594 Armour® 100x 120mg tablets retail $155 IAS price $149.99 - Item Code: 410 ERFA 100x 30mg tablets retail $55 IAS price $49.99 - Item Code: 736 ERFA 100x 60mg tablets retail $70 IAS price $64.99 - Item Code: 737 ERFA 100x 125mg tablets retail $95 IAS price $89.99 - Item Code: 738 Nature® 100x 15mg tablets retail $45 IAS price $39.99 - Item Code: 613 Nature® 100x 30mg tablets retail $50 IAS price $44.99 - Item Code: 324 Nature® 100x 60mg tablets retail $65 IAS price $59.99 - Item Code: 323 42

Thyrotropin releasing hormone (see TRH), TMG (trimethylglycine, betaine, see Beyond Chelation Improved®, Bio-En’R-Gy®), Tocotrienols (see Beyond Chelation Improved®), Tribulus terrestris (see Andro-Pro™, Beyond GHS®)

TRH (thyrotropin releasing hormone)

NEW: Abaris™ 20 x 5mg sublingual tablets retail $240 IAS price $199.99 - Item Code: 793

Trypsin (see Wobenzym®), TRX (see Hair-Pro™), Turmeric (see curcumin), Ubiquinol (see CoQ10), Ubiquinone (see CoQ10), Urea (see BEC5 Curaderm®), Urtica dioica (see Nanogen®)

Valdoxan® (agomelatine)

Valdoxan® 28x 25mg tablets retail $150 IAS price $144.99 - Item Code: 690

Vasopressin (also see desmopressin)

NEW: Vaso-Pro® 5 ml 500 IU nasal-spray retail $75 IAS price $69.99 - Item Code: 838

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43

VEGF (see Hair-Pro™, Nanogen® conditioner, Nanogen® serum, Nanogen® shampoo)

Venlafaxine (Efexor®)

Venlafaxine 60x 37.5mg tablets retail $49 IAS price $42.49 - Item Code: 488

Viagra® (sildenafil)

Viagra® 4x 100mg tablets retail $85 IAS price $79.99 - Item Code: 90

Vielight® laser

NEW: Vielight® 633 inter-nasal laser retail $300 IAS price $299.99 - Item Code: 958

Vincamine (see Anacervix®)

Vinpocetine

Intelectol® 50x 5mg tablets retail $19 IAS price $15.99 - Item Code: 91

Vitamin A (beta carotene, palmitate, see Beyond Chelation Improved®), Vitamin B1 (thiamine, see Beyond Chelation Improved®, Nitric-Pro™), Vitamin B1 (see benfotiamine), Vitamin B2 (riboflavin, see Beyond Chelation Improved®, Nitric-Pro™), Vitamin B3 (niacin, niacinamide, see Beyond Chelation Improved®, CrèmePro™ Cellulite, Nanogen® serum, Nitric-Pro™, picamilone; Xan-Pro™), Vitamin B5 (panthenol, pantothenic acid, see Beyond Chelation Improved®, Nitric-Pro™), Vitamin B6 (pyridoxine, see ACF228™, Andro-Pro™, Beyond B12®, Beyond Chelation Improved®, DIM-Pro2™, Gamalate B6®; HRT Plus®, Nanogen®; Nitric-Pro™), Vitamin B6 (see pyridoxamine), Vitamin B12 (cobalamin, see B12®, Beyond Chelation Improved®, CrèmePro™ Moisturizer, Cromatonbic®, DIM-Pro2™), Lithium, Neo40®), Vitamin D3 (cholecalciferol, see D3, Beyond Chelation Improved®, Bone-Pro2™, Prostate-Pro2™), Vitamin C (ascorbic acid, see Beyond Chelation Improved®, Bio-En’R-Gy C®, Digestif®; MinSaw™, Neo40®, Nitric-Pro™)

Vitamin E (tocopherols, see Beyond Chelation Improved®, Can-C Plus™, DIM-Pro2™, Nitric-Pro™, Prostate-Pro2™, Resveratrol-Pro™), Vitamin K2 (menatretrenone, see Beyond Chelation Improved®, Bone-Pro2™), Wheat grass (see Dr Gordon’s Organic Greens®)

Wobenzym-N®

Wobenzym® 200 tablets retail $75 IAS price $74.99 - Item Code: 381

Wormwood (see artemisinin)

Xan-Pro® (xanthinol nicotinate) Xan-Pro® 50x 150mg tablets retail $24 IAS price $19.99 - Item Code: 552

Yohimbine (also see Crème-Pro™ Cellulite)

Plain Prowess® 100x 5mg tablets retail $59 IAS price $49.99 - Item Code: 94

Zeolite

NEW: ZeoGold Enhanced® (zeolite and hydrogen) 50g powder retail $65 IAS price $64.99 - Item Code: 950 Advanced Cellular Zeolite®2 oz. spray retail $45 IAS price $42.49 - Item Code: 833

Zinc (see Andro-Pro™, Beyond Chelation Improved®, Can-C Plus™, MZS™, Nanogen® shampoo, Thym-Uvocal®) DIDN’T FIND WHAT YOU WERE LOOKING FOR? PLEASE CONTACT US WITH YOUR REQUIREMENTS.

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Condition cross reference list This cross-reference list highlights individual products that have been used to treat & prevent various aging disorders. Note: It does not mean that all these products are synergistic together.

Free radical: ACF228™ Glycation: Aminoguanidine Hayflick: L-carnosine, TA65® Membrane: Centrophenoxine Mitochondrial: Hydergine, PQQ Neuroendocrine: Metformin, TRH Rotational: Melatonin Telomeres: TA65®

Antibiotics (also see influenzas & infections) Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline

Anti-depressants (also see depression & wellbeing)

Lithium-Pro™, milnacipran (Ixel®), moclobemide (Manerix®), reboxetine (Edronax®), Stablon®, Valdoxan®, venlafaxine (Efexor®)

Anti-glycation (see AGE)

Adaptogens

HRT Plus®, maca, Quinton®

Anti-inflammatory (see inflammation)

Addison’s disease

Anti-oxidants (free radical scavengers)

ADHD (ADD, attention deficit disorder, see mental stimulants)

Anxiety (see stress)

Adrenal fatigue

ARMD (see eyesight)

Aldosterone, Peptide Bioregulator- Glandokort®

Aldosterone, hydrocortisone, Peptide Bioregulator Glandokort®

AGE (Advanced Glycated End Products, cross linking of proteins)

ACF228™, aminoguanidine, Can-C Plus™, L-carnosine, metformin, pyridoxamine

Age Related Macular Degeneration (see eyesight)

ACF228™, Active H-minus®, ATP-Boost™, Bio-En’RGy®, glutathione, idebenone, melatonin, pyritinol

Aromatase inhibitors

Anastrozole (Arimidex®), Beyond HRT®, DIM-Pro2™, progesterone

Arterial (See heart, arterial & blood) Arthritis (rheumatoid & osteo)

Gerovital-H3®, krill, Novisyn®, pregnenolone, pyritinol, SAMe, thymus, Wobenzym®

Age Related Mental Decline (see cognitive)

Asthma (see Allergies)

Aids (see HIV)

Autism (also see chelation agents)

Alcoholism (also see compulsive disorders) 5HTP, L-tryptophan, memantine

Oxytocin, piracetam

At-home therapeutic kits

B-Cure® laser, Vielight® laser

Allergies

Bio-En’R-Gy C®, pregnenolone, Thymus, Wobenzym®

Back Problems (see spine)

ALS (amyotrophic lateral sclerosis, see Lou Gehrig’s disease)

Bell’s palsy

Alzheimer’s (see senile dementia)

Beta blockers

Amino acids (including di-peptides)

5HTP, ACF228™, ATP-Boost™, Beyond GHS®, L-carnosine, L-tryptophan, Nitric-Pro

Beyond B12® Propranolol

Biological age measurement Bio-CLIP™, PulmoLife®

Anabolic (see growth hormone & testosterone)

Blood disorders (see heart, arterial & blood)

Anginas (see heart, arterial & blood)

Blood pressure

Animal use

Can-C™ eye-drops, deprenyl, L-tryptophan, peptide bioregulators

Antiaging (as impacting on a particular theory of aging) Calorie Restriction: L-carnosine, metformin, resveratrol

Neo40®, Nitric-Pro™, oxytocin, propranolol, vinpocetine

Bone problems (also see joints & arthritis)

Andro-Pro™, Bone-Pro2™, Esnatri™, Peptide Bioregulator - Bonomarlot®, progesterone, SAMe, thyroid

Breathing (see Lungs)

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Cancer (also see anti-oxidants & radiation)

1st Line™, anastrozole (Arimidex®), artemisinin, BEC5® Curaderm, Bio-En’R-Gy C®, bromocriptine, CurcuminSR™, D3, DIM-Pro2™, HRT Plus®, laetrile, melatonin, metformin, naltrexone, progesterone, Resveratrol-Pro™, thymus, TRH, Wobenzym®

Cardiovascular (see heart & arterial disorders) Cataplexy (sudden fatigue)

Adrafinil, modafinil, picamilone

Cataract (also see eyesight) Can-C™, Can-C Plus™

Central Nervous System (CNS) Peptide Bioregulator - Cerluten®

Chelation agents (removing heavy metals, also see detox)

Beyond Chelation Improved®, Beyond Fiber®, Bio-En’RGy C®, centrophenoxine, Dr. Gordon’s organic greens®, L-carnosine, zeolite

Cholesterol (see blood disorders) Crohn’s disease Naltrexone

Acarbose, aminoguanidine, ATP-Boost™, benfotiamine, krill, L-carnosine, metformin, Nitric-Pro™, Peptide Bioregulator- Suprefort®, pyridoxamine, TRH, thyroid

Diabetes insipidus (see urination) Diagnostic products (see at-home diagnostics and at-home test kits) Dieting (See weight loss) Digestive issues

Beyond Fiber®, Digestif®, Dr. Gordon’s organic greens®, Peptide Bioregulator - Stamakort®

DNA support (also see telomeres)

CoQ10, D3, krill, L-carnosine, Peptide Bioregulators, PQQ, Resveratrol-Pro, TA65®

Down’s syndrome

Melatonin, piracetam

Dr. Gordon’s recommended products

Beyond B12®, Beyond Chelation Improved®, Beyond Clean2®, Beyond Fiber®, Beyond GHS®, Bio En’R-Gy C®, Dr Gordon’s Organic Greens®, HRT Plus®, maca, silver protein, zeolite

Chronic fatigue syndrome (see mental stimulants & physical energy improvement)

Dr. Pierpaoli’s recommended products

Cognitive (also see memory & senile dementias)

Dr. Wright’s recommended products

Alertness: Adrafinil, modafinil Creativity: Aniracetam, piracetam, pramiracetam Focus/ concentration: Deprenyl, desmopressin, phosphatidylserine, vasopressin Energy: ATP-Boost™, centrophenoxine, picamilone General support: Gerovital-H3®, vinpocetine Intelligence: Hydergine Work load: Hydergine, thyroid

Compulsive disorder treatment (also see alcoholism)

5HTP, Gamalate®, L-tryptophan, picamilone

Cortisol alteration (also see stress)

Aldosterone, fludrocortisone, GABOB, Gamalate®, hydrocortisone, Peptide Bioregulator - Glandokort®, Gerovital-H3®, phenytoin

Cross linking (see AGE) Deep vein thrombosis (see frequent fliers) Dental (see teeth & gums) Depression (also see well-being & anti-depressants) 5HTP, aniracetam, ATP-Boost™, CurcuminSR™, D3, deprenyl, Gerovital-H3®, Lithium, L-tryptophan, milnacipran, picamilone, piracetam, pramiracetam, pregnenolone, SAMe, thymus, thyroid

Detox (also see chelation agents)

Artemisinin, Bio-En-R-Gy C®, Beyond Clean®, Beyond Fiber®, DIM-Pro2™, Dr. Gordon’s organic greens®, zeolite

DHT alteration (dihydrotestosterone)

Dutasteride, finasteride, Hair-Pro™, MinSaw™, Nanogen’s®, Peptide Bioregulator - Libidon®, progesterone

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Diabetes

Melatonin, TRH

Esnatri, cobalt chloride, progesterone

Energy improvement (see physical energy & mental stimulants)

Enzymes

Boluoke®, Wobenzym®

Epilepsy

GABOB, Gamalate®, phenytoin

Erectile dysfunction (also see sex-libido & premature ejaculation)

Andro-Pro™, cabergoline, Cialis®, Neo40®, Nitric-Pro™, oxytocin, Viagra®, yohimbine

Estrogen alteration (both increases & decreases)

Anastrozole (Arimidex®), cobalt chloride, DIM-Pro2™, Esnatri™, HRT Plus®, progesterone

Excitotoxins (reduction)

Deprenyl, idebenone, L-carnosine, Lithium, memantine

Eyesight (also see cataract, ARMD & glaucoma)

ARMD: MZS™ Cataracts: Can-C™, Can-C™ Plus Contact lenses: Can-C™ Dry eyes: Can-C™ General support: Aminoguanidine, Peptide Bioregulator - Visoluten®, vinpocetine Glaucoma: Can-C™ Retinal: MZS™, nicergoline, picamilone

Fertility

Melatonin, metformin, Peptide Bioregulator - Zhenoluten®, TRH

Fibromyalgia (also see physical energy & mental

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stimulants & pain relief)

1st Line, milnacipran, naltrexone, oxytocin

First Aid cabinet

Free radical scavengers (see anti-oxidants) Frequent fliers

1st Line, artemisinin, GABOB, Gamalate®, L-tryptophan, melatonin, Neo40®, Nitric-Pro™, picamilone, piracetam, pregnenolone, Resveratrol-Pro™, silver protein

Gastrointestinal (see digestive) Glaucoma (see eyesight)

Hormones (includes hormonal support supplements) Bio-identical: Aldosterone, Esnatri™, melatonin, MSH, oxytocin, pregnenolone, progesterone, TRH Natural (animal): Armour® thyroid, ERFA® thyroid, Nature® thyroid, thymus, vasopressin Synthetic: Desmopressin, Eutirox® thyroid, fludrocortisone, hydrocortisone, T3Pro™ Supporting agents: Peptide Bioregulators, Cobalt chloride, DIM-Pro2™, GHRP2, GHRP6, sermorelin

HRT (hormone replacement therapy for women)

Glucose control (see diabetes)

Cobalt chloride, Esnatri™, HRT Plus®, melatonin, progesterone

Glycation prevention (see AGE)

Human growth hormone (see growth hormone)

Gout

Hydrogen

Colchicine

Active H-minus®, ZeoGold Enhanced®

Growth hormone (improvement)

Beyond GHS®, bromocriptine, deprenyl, GABOB, Gamalate®, GHRP2, GHRP6, hydergine, Neo40®, NitricPro™, sermorelin, thymus, thyroid

Hair improvement

Dercos®, dutasteride, finasteride, Gerovital-H3®, HairPro™, krill, MinSaw™, Nanogen’s, Nitric-Pro™, Nizoral®

Headaches (see migraines) Health diagnostics (see at home test kits) Hearing disorders

Aldosterone, Anacervix®, fludrocortisone, nicergoline, picamilone, vinpocetine

Heart, arterial & blood (includes blood markers)

Arteries (hard): Aminoguanidine, Bio-CLIP™, BioCUFF™, L-carnosine, Resveratrol-Pro™ Blood pressure (high): Neo40®, Nitric-Pro™, Propranolol, vinpocetine Calcium: Peptide Bioregulator - Bobothyrk® Cholesterol (high): Beyond B12®, Beyond Fiber™, CoQ10, Gerovital-H3®, TRH, Xan-Pro™ Dilation (nitric-oxide): Neo40®, Nitric-Pro™, Vielight® Fibrinogen: CurcuminSR™, TRH, Wobenzym® General support: CoQ10, krill, Peptide Bioregulators Chelohart® & Ventfort®, PQQ, vinpocetine, Wobenzym® Glucose (high): Acarbose, metformin, TRH Glycated end-products: Aminoguanidine, metformin Heart pulse (irregular): ATP-Boost™, Bio En’R-Gy C®, thyroid Heavy metals (chelate): Beyond Chelation Improved®, Beyond Fiber®, Bio En’R-Gy C® Hemorrhoids: Nitric-Pro™ Homocysteine: Beyond B12®, Beyond Chelation Improved®, Bio En’R-Gy C®, TRH Lipofuscin: Centrophenoxine Plaques (clots): Boluoke® Triglycerides: Bio En’R-Gy C®, CurcuminSR™, krill, TRH

Hepatitis (see liver and infections) 1st Line™, ACF228™, silver protein, Wobenzym®

HGH (see growth hormone)

1st Line™, melatonin, naltrexone, Thymus

Homocysteine (see blood disorders)

1st Line™, HemaGel®, silver protein

Herpes (also see anti-biotics)

HIV (also see immune system improvement)

Hypertension (see blood pressure) Immune system improvement (also see infections) 1st Line™, ATP-Boost™, Beyond B12®, L-carnosine, maca, melatonin, Peptide Bioregulator- thymus (Vladonix®), Peptide Bioregulator- thyroid (Thyreogen®), pyritinol, Resveratrol-Pro™, thymus, thyroid

Infections (also see immune system improvement, anti-biotics & influenzas)

1st Line™, artemisinin, fluconazole, silver protein, Wobenzym®

Inflammation (reduction)

Beyond Chelation Improved®, Bio-En’R-Gy®, Boluoke®, CurcuminSR™, Digestif®, Dr. Gordon’s organic greens®, krill, maca, pregnenolone, thymus, Wobenzym®

Influenzas (also see anti-biotics, infections & immune system improvement) 1st Line™

Injectable products

Cerebrolysin®, Cromatonbic® (B12), Gerovital-H3®

Insulin & glucose control (see diabetes) Intestinal flora (see probiotics) Inter-nasal products

Desmopressin (Minirin®), MSH (MSH2-Pro™), oxytocin (Oxy-Pro™), GHRP6 (Releasing-Pro™), vasopressin (Vaso-Pro™), Vielight® laser

Joints (also see bones & arthritis)

Boluoke®, krill, Peptide Bioregulator- Sigumir®, Novisyn®, pregnenolone, SAMe, thymus, Wobenzym®

Kidney disorders (also see infections)

Aminoguanidine, Peptide Bioregulator - Pielotak® SAMe, TRH

Learning (also see memory & mental stimulants) Aniracetam, desmopressin, hydergine, piracetam, pramiracetam, vasopressin

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Libido (see sex) Lipids (see blood disorders) Liver disorders (also see infections)

CoQ10, Idebenone, Peptide Bioregulator- Svetinorm®, pregnenolone, SAMe, silver protein

Longevity enhancement (significant lifespan increases seen in animal studies)

Centrophenoxine, deprenyl, Desmopressin, melatonin

Lou Gehrig (ALS) Naltrexone, TRH

Lungs

ACF228™ Breathe-Easy, Centrophenoxine, Nitric-Pro™, Peptide Bioregulator - Taxorest®, PulmoLife®

Lupus

Milnacipran, naltrexone

Lyme’s

1st Line™, silver protein

Macular degeneration (see ARMD & eyesight) Malaria (also see anti-biotics) Artemisinin

Memory (also see cognitive & senile dementia)

General support: Krill, picamilone, vinpocetine Imprinting (for later recall): Desmopressin, vasopressin Medium-long term: Hydergine, phosphatidylserine Short term: Aniracetam, piracetam, pramiracetam Speed of recall: Centrophenoxine, pyritinol

Menopause (see HRT) Mental stimulants (also see physical stimulants) Adrafinil, aniracetam, centrophenoxine, deprenyl, desmopressin, modafinil, nicergoline, picamilone, piracetam, pramiracetam, vasopressin, Xan-Pro™

Methylation (conversion of one chemical into another inside the body)

ATP-Boost™, Beyond B12® Bio-En’R-Gy®, Boluoke®, SAMe, Wobenzym®, Xan-Pro™

Migraines (also see pain relief)

Beyond B12®, nicergoline, memantine, picamilone, Quinton®

Minerals (including trace- also see vitamins)

Beyond Chelation Improved®, Bone-Pro2™, Gamalate®, Quinton®

Mitochondrial support

ATP-Boost™, CoQ10, deprenyl, glutathione, hydergine, idebenone, PQQ, pregnenolone, SAMe

Multiple Sclerosis (also see mitochondrial support) Melatonin, naltrexone, TRH

Nitric-Pro™, Neo40®, Nitric Oxide saliva test strips

Oral health care (see teeth & gums) Osteoporosis (see bone problems) Pain relief

ATP-Boost™, Gerovital-H3®, memantine, milnacipran, nicergoline, oxytocin, Wobenzym®

Parasites (see infections) Parkinson’s disease (see senile dementia) Peptides

-short chain peptide bioregulators Adrenals = Glandokort®, Bladder = Chitomur® Blood vessels = Ventfort®, Bone marrow = Bonomarlot® Brain (CNS) = Cerluten®, Cartilage = Sigumir® Heart = Chelohart®, Kidney = Pielotak®, Liver = Svetinorm®, Lungs = Taxorest® Muscle = Gotratix®, Ovaries = Zhenoluten® Pancreas = Suprefort®, Parathyroid = Bobothyrk® Pineal = Endoluten®, Prostate = Libidon® Retina = Visoluten®, Stomach = Stamakort® Testes = Testoluten®, Thymus = Vladonix® Thyroid = Thyreogen® -other peptides Cerebrolysin®, GHRP2 (GHRP2-Pro™), GHRP6 (Releasing-Pro™) Sermorelin (Serm-Pro™), TRH (Abaris™)

Pets (see Animal use) Photoaging (see radiation & skin problems) Ph balance (rebalancing)

Active H-minus®, Dr. Gordon’s organic greens®, Quinton®

Physical energy improvement (also see mental stimulants)

Active H-minus®, ATP-Boost™, Beyond B12®, CoQ10, idebenone, L-carnosine, maca, PQQ, pregnenolone, SAMe, yohimbine

PMS (pre-menstrual syndrome)

Beyond B12®, krill, HRT Plus®, maca, Peptide Bioregulator - Zhenoluten®, vinpocetine

Premature ejaculation/ ejaculate (also see erectile dysfunction & sex-libido) Oxytocin

Probiotics

Beyond Fiber®, Digestif®, Dr. Gordon’s organic greens®, Quinton®

Prostate (also see cancer)

Beyond B12™, D3, DIM-Pro2™, dutasteride, finasteride, HRT Plus®, melatonin, Peptide Bioregulators - Chitomur® & Libidon®, Prostate-Pro2™

Nail condition

Prolactin alteration

Narcolepsy (sleeping in the daytime)

PSA (prostate specific antigen- see prostate)

Gerovital-H3®, krill Adrafinil, melatonin, modafinil, picamilone

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Nitric Oxide release

Bromocriptine, cabergoline, GABOB, Gamalate®

Urination (frequent)

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Peptide Bioregulator -Chitomur®, vasopressin

Radiation (see skin problems)

Sunburn (see radiation) Syndrome X (metabolic syndrome)

Aminoguanidine, ATP-Boost™, krill, melatonin, metformin

RNA (see DNA support) Senile dementia (also see cognitive & memory)

Alzheimer’s: Centrophenoxine, CurcuminSR™, galantamine, hydergine, memantine, nicergoline General support: Anacervix®, aniracetam, piracetam, pramiracetam, vinpocetine, Wobenzym® Parkinson’s: Bromocriptine, cabergoline, deprenyl, rasagiline

Senility

Tanning (darkening the coloration of skin) MSH

Teeth & gum disorders

Doxycycline, Gengigel®, NeyDent®, silver protein, Quinton®, zeolite

Telomeres (also see DNA support) Krill, L-carnosine, TA65®

Gerovital-H3®

Sex (libido, also see erectile dysfunction & premature ejaculation)

Andro-Pro™, deprenyl, maca, MSH, oxytocin, yohimbine

Skin problems (also see tanning)

Acne: Nexiclear® Age: (liver) spots: Centrophenoxine Anti-glycation: Aminoguanidine, L-carnosine Anti-oxidant: Crème-Pro™ Protector Cancer (non-melanoma): BEC5® Curaderm Cellulite: Crème-Pro™ Celluless Collagen: Hy-Col™ Environmental: Crème-Pro™ Protector Fine lines: Crème-Pro™ Smoother General support: Gerovital-H3®, Quinton®, thyroid Hyaluronic acid: Hy-Col™ Infections: Silver protein, Thym-Uvocal® Moisturizer: Crème-Pro™ Moisturizer Psoriasis: Nexiclear® Radiation: Crème-Pro™ Protector, melatonin Scars/ stretch marks: Tamanu oil Sun spots: BEC5® Curaderm Wounds: HemaGel® Wrinkles: Retin-A®

Sleep disorders

For less sleep: adrafinil, ATP-Boost™, modafinil For more sleep: 5HTP, gabapentin, L-tryptophan, melatonin

Smoking cessation 5HTP

Testosterone & testes (also see fertility and prostate) Andro-Pro™, Anastrozole (Arimidex®), Beyond B12®, Beyond GHS®, DIM-Pro2™, melatonin, oxytocin, Peptide Bioregulator - Testoluten®, TRH

Therapeutic equipment (see at-home therapeutics) Thyroids

Natural brands: Armour®, ERFA®, West® (Nature®) Synthetic brands: IBSA® (T3+T4), Eutirox® (T4), Tiromel® (T3) Supporting agents: Peptide Bioregulator - Thyreogen®

Travel (see frequent fliers) Triglycerides (see blood disorders) Veterinarian (see animal use) Vitamins (also see minerals)

Benfotiamine, Beyond B12®, Beyond Chelation Improved®, Bio- En’R-Gy C®, CoQ10, D3, GABOB, Gamalate®, Nitric Pro™, PQQ, pyridoxamine, Xan-Pro™

Water

Active H-minus®, Quinton®

Weight gain (muscle mass)

Andro-Pro™, Beyond GHS®, GABOB, GHRP6, sermorelin

Weight loss (Appetite suppressants and diet aids)

Spine Issues

Peptide Bioregulator- cartilage (Sigumir®), Novisyn®

Sports (see growth hormone, estrogen alteration, physical energy & testosterone)

Stress (also see cortisol)

5HTP, GABOB, Gamalate® , Gerovital-H3®, maca, L-tryptophan, melatonin, oxytocin, picamilone, phenytoin, propranolol, pregnenolone

5HTP, acarbose, aminoguanidine, ATP-Boost™, benfotiamine, Beyond Fiber®, DIM-Pro2™, Dr. Gordon’s organic greens®, galantamine, GHRP2, L-tryptophan, metformin, MSH2, thyroid, TRH, Xan-Pro™

Well-being (also see depression)

5HTP, Active H-minus®, aniracetam, ATP-Boost™, Beyond B12®, deprenyl, Gamalate®, Gerovital-H3®, krill, L-tryptophan, melatonin, picamilone, piracetam, pramiracetam, SAMe, thymus, thyroid, Wobenzym®, ZeoGold Enhanced®

Stroke

Anacervix®, aniracetam, Boluoke®, hydergine, idebenone, nicergoline, Nitric-Pro™, picamilone, piracetam, PQQ, pramiracetam, pregnenolone, vinpocetine

Stomach (see digestive) Sublingual products

Beyond B12™, Oxytocin (Oxy-Sub™), Sermorelin (SermPro™)

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