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No 4, 2015

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PLUS: Updating the calorie restriction mimetics Aging, muscles and exercise Dr Ward Dean answers your questions The in-house magazine for International Antiaging Society Group Private Club Members


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WELCOME It doesn’t happen very often - that is a food supplement being examined under double-blind, placebo controlled clinical standards. But that is exactly what has occurred with a British probiotic called Symprove®. Two London Universities have independently scored it as excellent and one has highlighted how successful it is in the treatment of severe IBS, (irritable bowel syndrome) - a condition that can be very painful and debilitating. Meanwhile, calorie restriction remains currently the only ‘proven’ life extension method for mammals, (and therefore presumably humans too); but no one can deny that a near starvation diet is one that most people would not care to endure. So maybe the answer lies in Dr. Marios Kyriazis article about ‘calorie restriction mimetics?’ CRMs are substances that can ‘trick’ the body into believing it is consuming less. Plus, Dr. Richard Lippman looks at what can happen to our fitness as we age, noting that older individuals need to be careful in the type and vigor of the exercise they choose. He shows us that hormones, free radical scavengers and peptides can help to overcome damage- to prevent sarcopenia, (the loss of muscle strength and mass). Okay, I’m off to the gym!

CONTENTS WELCOME Phil says thanks for finding the time


FOREFRONT This month’s news


A PROBIOTIC THAT CAN BEAT IBS Discover the clinical facts about Symprove®


UPDATING THE CALORIE RESTRICTION MIMETICS How to trick our body to consume less


AGING, FITNESS AND MUSCLES Battling the physical changes with age


DR . WARD DEAN ANSWERS YOUR QUESTIONS One of our most popular features


FEATURED PRODUCTS Best sellers and new items

Phil Micans, MS, PharmB Editor, Aging Matters™ Magazine

Ward Dean M.D., Medical Director


A-Z PRODUCT LISTING AND PRICES Find everything in-stock here


CROSS -REFERENCE LISTS Find what you need here




IAS is dedicated to helping you access the world’s latest commercially available supplements- to give you and your family real choices in health and wellness. IAS promises you:

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• Quality: We stock the best quality products because the right materials and formulas give you the best possible results. • Brands: We carry original brands - i.e. the same ones used by top health professionals. • Choice: We have the largest range of medicines, hormones and supplements. If you are looking for things that use words like bioidentical, efficacy and synergy then you’ve come to the right place. • Pricing: Our prices are competitive and we regularly have special offers to help you save money on the things that are important to you and your family. • Support: Our friendly and professional customer care team are on-hand to help you. We can be bothered! • Professional: We work alongside the leaders in the field and we review the latest research to ensure that everything is up-to-date. After all, if we are informed then so are you. • Sponsorship: All over the world you will find IAS supporting, sponsoring, exhibiting and lecturing at key venues. You can meet us in person and see what we believe in.

Declaration: The IAS Aging Matters™ magazine is intended for IAS private club members (and therefore is not intended for the public). It focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental and internal changes consisting of the diseases and disorders such as cancer, arthritis and senile dementias etc. However, the main focus is upon the prevention of such aging diseases and disorders for the ‘healthy-aging’ individual. Copyright 2015: All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork or advertising materials while in transmission or with the publisher or their agents. Disclaimer: All educational information is offered under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS or the magazine. All prices shown are in US Dollars and are for reference purposes only and they do not include taxes (where applicable), nor do they include shipping & handling fees. Prices, conditions and terms are subject to change without notice.



Inflammation and Lifespan A new study from researchers at the University of California’s San Diego School of Medicine has revealed that mammal species with higher numbers of siglec receptor genes, that protect us from inflammatory collateral damage have longer

maximum lifespans of 14 mammalian species, including those of elephants, dogs, monkeys and humans. They also demonstrated that mice who were missing one the CD33rSiglec family of proteins showed signs of accelerated aging (grey hair

to siglec receptors, they transmit the message to the cell to cease immune cell activation, which dampens chronic inflammation and reactive oxygen species in the body. “Though not quite definitive, this finding is

“As far as we know, it’s the first time lifespan has been correlated with simple gene copy number.” maximum lifespans. As we age inflammation and chemically active molecules called reactive oxygen species, that help fight infection, also cause damage that over time contributes to increased frailty, disability and disease. To arrive at the finding the team mapped CD33rSIGLEC gene copy numbers and correlated them with the


and thin skin), had higher levels of reactive oxygen species didn’t live as long as normal mice. The CD33rSIGLEC genes instruct the siglec receptors that bind sialic acids, the sugar molecules found on many cells. When sialic acids bind

provocative. As far as we know, it’s the first time lifespan has been correlated with simple gene copy number,” said Ajit Varki, MD, Professor of Medicine and Cellular and • Order hotline: 1-866-800-4677 • e-mail:

Molecular Medicine. “Since people also vary in number of CD33rSIGLEC gene copies, it will be interesting to see if these genes influence variations in human lifespan as they do in mice.” Another researcher from the team Pascal Gagneux, PhD, associate professor of pathology added “The higher CD33rSIGLEC gene number can be thought of as an improved maintenance system that coevolved in mammals to buffer against the effects of many infectious episodes fought off by the immune system of long-lived mammals,”.

FOREFRONT Viva Vitamin D Not a week seems to go by without more research being published extolling the benefits of vitamin D, this time new research from Cambridge University in the UK revealed the positive effects of maintaining high concentrations in the blood. The study was designed to discover the optimal blood levels of the vitamin and followed 641 adults aged between 42 and 82 for 13 years. Data revealed that for every 2- nmol/L increase in serum 25-hydroxyvitamin

D, the risks of cardiovascular disease decreased by 4%, respiratory disease by 11%, and fractures by 11%. The lowest mortality rates were observed in individuals with serum 25-hydroxyvitamin D concentrations above 90 nmol/L. Vitamin D is cheaply and widely available but the evidence is mounting that it is a vital vitamin and people of all ages should seek to maintain an optimal level year round.

Magnesium Improves Metabolic Markers Researchers from France collected data from the US National Health and Nutrition Examination Survey (NHANES), 20012010 and determined the magnesium intake from food alone and also from food plus dietary supplements. Adults with an adequate intake of magnesium from their diet had significantly different HOMA-IR – a measure of insulin resistance,

systolic blood pressure, and HDL-cholesterol, compared to subjects with inadequate intake of magnesium from food. Adults with an adequate intake of magnesium from food that also took a dietary supplement had significant differences in waist circumference, systolic blood pressure, and HDL (high-density lipoprotein) cholesterol. The team observed that a higher dietary intake of magnesium from all sources

was associated with “significantly reduced odds ratios for elevated glycohemoglobin, metabolic syndrome, obesity, overweight or obesity, elevated waist circumference, elevated systolic blood pressure, reduced HDL and elevated C-reactive protein.” The study authors concluded that: “there is a beneficial relationship between dietary magnesium intake and diabetes-related physiological outcomes.”

“...there is a beneficial relationship between dietary magnesium intake and diabetes-related physiological outcomes.” • Order hotline: 1-866-800-4677 • e-mail:



THAT BEATS IBS Symprove® is scientifically proven to outperform other leading probiotic brands... By Leslie J. Farer

6 • Order hotline: 1-866-800-4677 • e-mail:

Over the past few years, probiotics have become increasingly popular among health-conscious consumers for their wide range of preventive and therapeutic benefits, and are now a major sector of the nutritional supplements industry. Considering that probiotics, or beneficial bacteria, support the immune and gastrointestinal (GI) systems, inhibit harmful pathogens, reduce the occurrence of allergies, and protect against a variety of chronic diseases, their popularity is not surprising. But with this rise of interest comes an ever increasing number of products on the market which range in quality from those that have been scientifically validated and tested in clinical studies, to those with unsubstantiated claims of potency and efficacy.

How do you know what you’re getting when you purchase?

In choosing a product, make sure it meets these criteria or quality standards: (1) It must be demonstrated to contain sufficiently large numbers of live, viable bacteria which are resilient enough to survive transit through the hostile environment of the GI tract and form healthy colonies; (2) It must be proven effective in providing a health benefit as demonstrated in a controlled clinical study; (3) It must be manufactured according to strict quality control and purity standards, with each batch tested for identity and potency. Of the hundreds of products on the market to choose from, one stands above the competition and meets each of these criteria: Symprove®, a high-quality, high-potency liquid product containing live active cultures of four probi-

otic strains. Let’s examine the wide-ranging benefits of probiotic supplementation and the importance of choosing a scientifically verified and clinically proven product.

Probiotics Defined

The term “probiotics” literally means “for life.” The United Nations Food and Agricultural Organization and the World Health Organization define probiotics as “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host.” (1,2) Note that the organisms must be delivered live and in sufficient numbers to the gut, and that they must produce some beneficial effect(s) on the host animal or human. As we’ll see below, Symprove® was confirmed to meet both parts of the technical definition of probiotics; not all products that are labeled “probiotic” meet these standards. Probiotic bacteria are classified according to their particular genus, species, and strain. Within each genus are multiple species (for example, the genus Lactobacillus currently consists of over 125 species, such as L. acidophilus and L. rhamnosus), and within each species, different strains. Each species and strain has specific actions and uses.

ing qualities have been widely touted for centuries, as in the case of the villagers of the Caucasus Mountains whose frequent consumption of yogurt has long been associated with good health and longevity. Since the first clinical trials in the 1930’s, researchers have demonstrated the broad array of health benefits provided by probiotic supplementation. Beneficial bacteria may best be known for their role in contributing to GI health. They improve intestinal microbial balance, and enable the digestive system to function optimally. In fact, the intestinal tract is a mini-ecosystem (part of the human microbiome) - home to over a hundred trillion bacteria, from four to five hundred different species, in addition to a host of other microorganisms such as yeasts, fungi and protozoa. The key to good health is a positive balance of all of these “residents,” with sufficient numbers of beneficial bacteria performing all of

their vital roles while keeping the less desirable pathogenic microbes in check. Probiotics have been shown to be especially useful in the treatment of diarrhea resulting from antibiotic use (which can decimate intestinal bacteria, both the good and the bad), rotaviruses (in young children) and traveling. Certain probiotics, including some Lactobacilli, may relieve constipation as well as alleviate symptoms of lactose intolerance and malabsorption by producing lactase in the intestine and stomach. Probiotic bacteria have also had success in treating irritable bowel syndrome (IBS) and inflammatory bowel diseases such as colitis and Crohn’s disease. We’ll examine in detail below a clinical study in which Symprove significantly improved IBS-related symptoms. Since the GI tract is intimately connected with the immune system, probiotics also play a role in the immune response. They inhibit

Health Benefits of Probiotics

Probiotic cultures have been used for thousands of years, originally as a means of food preservation, in cultured milk products and fermented foods. Their health-promot-

Figure 1: Probiotic bacteria • Order hotline: 1-866-800-4677 • e-mail:


the growth of a variety of dangerous microbes (including common bacterial pathogens such as Salmonella and Shigella) and enhance immune factors. Without a healthy microbial balance in the gut, the immune system can’t function properly to ward off infection. Probiotics have been shown effective in such diverse conditions as colon cancer, where they may reduce the incidence and number of tumors, autism, urinary tract and respiratory infections, bacterial vaginosis, allergies, high cholesterol, high blood pressure, and diabetes. And, among other numerous roles of probiotics is the synthesis of vital nutrients such as B vitamins and Vitamin K.

Sources of Probiotics: Food vs. Supplements

So, where can you obtain these beneficial bacteria? Good sources of probiotics include cultured milk products such as yogurt and kefir and fermented foods popular in Europe and Asia, such as pickled vegetables, sauerkraut, kimchi (a traditional Korean pickled dish) and miso. But as healthy as these foods may be, it’s impossible to know just how many live, viable organisms are in the portion you’re consuming. Clinical studies indicate that an effective dose of probiotics is in the range of one to 10 billion CFU’s per day. (A CFU, or colony forming unit, is a measure of viable, live bacteria which divide to form colonies.) Daily consumption is essential - most probiotics do not permanently inhabit the intestines. Commercial yogurt manufacturers generally list on the product’s label the species of probiotic bacteria used and the “Live Active Culture” seal, but not 8

the actual number of cultures. Due to the inherent variability in manufacturing processes, it’s impossible to know exactly how many live bacteria reside in a container of yogurt (unless analyzed by a commercial lab), especially when you factor in storage and transit conditions, and shelf life. Yogurt and other cultured foods are a valuable addition to the diet, but in order to obtain the higher end of the recommended probiotic dose (10 billion CFU’s per day) to maximize health benefits, supplementation with a probiotic product is essential. But which one?

How to Choose a Product

As mentioned, there’s a plethora of probiotics on the market, in the form of liquids, tablets, powders, and capsules, and choosing one can be a daunting task, unless you can be sure it conforms to the three fundamental criteria outlined earlier. First, for a product to be effective, the bacteria it contains must be live and active, and in sufficient numbers when consumed. And the formulation must ensure that the bacteria will survive the various trips involved from the point of manufacture to your home, and then the more challenging voyage through your stomach to your colon, where they must multiply and form colonies. (We’ll refer to adequate potency and viability of the bacteria in a probiotic product as Criterion 1.) Second, the product should be evaluated for efficacy in a clinical study; i.e., it must provide a measurable health benefit(s) (Criterion 2). And third, the product must be manufactured with high quality control and purity standards (Criterion 3). You really can’t be sure what you’re getting unless the product conforms to these

quality standards.

Most Probiotics Don’t Deliver, but One Does

To provide much needed independent and comparative scientific data on the potency and quality of commercially available probiotic supplements (in other words, to address Criterion 1 on our list), scientists from the University College London School of Pharmacy conducted a study on eight commercial brands. Using test conditions that simulate the human GI tract, the researchers conducted three “challenge tests” to investigate whether the bacteria in each product (1) were present in the amounts stated on the label; (2) survived transit through the stomach; and (3) had the potential to form healthy colonies after exposure to gastric fluid. The eight probiotic brands were Actimel®, Align®, Symprove®, Biobalance®, Probio7®, Yakult®, VSL#3®, and Bio-kult®. In the first test on label claim, only liquid products (dairy-based Actimel® and Yakult® and water-based Symprove®) contained 100 percent or more of the labeled content of live bacteria. Freeze-dried, or lyophilized, products scored lower recoveries of live organisms; in these formulations, bacteria must rehydrate to return to a metabolically

active state, which often results in the loss of numbers of organisms. Liquid products, on the other hand, contain bacteria that are already in an active state and scored higher recoveries. In the second challenge test, the eight probiotic brands were submitted to simulated and porcine gastric fluids to mimic the acidic conditions of the human stomach. Most products showed a sharp decline in the number of bacteria after only five minutes in an acidic environment. Only two products contained bacteria that survived a full two hours (equivalent to stomach transit time) in gastric fluid, one (Symprove®) more robustly than the other (VSL#3®). The third challenge test evaluated whether the bacteria in each of the products could grow and multiply within 10 hours after exposure to gastric fluid, a measure of their potential to colonize in the human GI tract. Only three of the eight products showed signs of strong growth within 10 hours (Actimel®, Symprove®, VSL3®). Again, in order to be effective, a probiotic product must pass all three challenge tests: it must arrive alive (i.e. in sufficient numbers when

ARRIVE 100% of Symprove live bacteria are delivered live and active.

SURVIVE 100% of Symprove live bacteria survive stomach acid.

THRIVE 100% of Symprove live bacteria reach the gut, where they can thrive.

Figure 2: Symprove® passed all three challenge tests • Order hotline: 1-866-800-4677 • e-mail:

Figure 3: Improvement in IBS symptom severity with Symprove®



Reduction in Symptom Severity

300 290

Symprove Placebo


280 270 260 250 240 230 BASELINE


consumed), survive stomach acid, and then thrive, or colonize in the intestines. If a product fails just one of these tests, it will be worthless (and four products failed all three!). Symprove was the only product that passed all three challenge tests, the equivalent of Criterion 1 on our list. Symprove’s unsurpassed performance in these in vitro experiments underlies its efficacy in vivo: in a controlled clinical study, it significantly alleviated troublesome symptoms associated with IBS, satisfying Criterion 2.

Symprove Effective in Treating IBS

IBS is a GI disorder characterized by abdominal pain, bloating, and bouts of diarrhea and/or constipation (not to be confused with inflammatory bowel disease). The condition is estimated to affect up to 15 percent of the population worldwide, and due to its problematic symptoms, results in reduced quality of life. Multiple factors may contribute to IBS, such as stress, depression, food sensitivities, hormonal changes, and imbalanced gut flora. Conventional treatments include drugs that are often ineffective in the long-term and laden with side effects. Because probiotics



improve intestinal microbial balance, they are a promising alternative treatment, free of side effects. In a 12-week placebo-controlled double-blind study at King’s College Hospital London, 186 patients with moderate to severe IBS received either Symprove® or a placebo, 1 ml/kg (which corresponds to approximately 68 ml for a 150-lb person or 55 ml for a 120-lb person) daily. The degree of symptoms, such as pain, constipation, diarrhea, and bloating, was measured at the beginning and end of the trial using a clinical tool known as the IBS symptoms severity score. By week 12, researchers noted a statistically significant improvement in overall symptom severity in patients who received Symprove® versus placebo. In most treated patients, pain, the predominant IBS symptom, as well as constipation and diarrhea, were reduced; by the end of the study, a quarter of these patients experienced minimal or no symptoms, an impressive outcome, especially as the patients were suffering from moderate to severe IBS. In addition, the product was well tolerated, even in these patients with pre-existing GI disturbances. (3) Bear in mind that probi-

otics are classified as foods, and so are not subject to the rigorous testing required for drugs. However, what’s noteworthy about this study, besides demonstrating Symprove’s efficacy in the human gut, is that it followed the standards equivalent of a drug trial, (i.e., the study design was randomized, double-blind, placebo-controlled). Future research is underway to evaluate the efficacy of Symprove® in treating inflammatory bowel disease and diverticular disease.

What exactly is Symprove®

Symprove® is an aqueous extract of germinated barley containing live active cultures of four probiotic species: L. rhamnosus, E. faecium, L. plantarum, and L. acidophilus. Germinated barley extract acts as a substrate or prebiotic, helping the bacteria grow. Symprove’s formulation, or “Unique Delivery System,” protects and transports live probiotic bacteria safely through the stomach to the target area of the colon. Again, the bacteria in the product are live, which means actively metabolizing and dividing. The product is manufactured in a next-generation facility in the UK, in a clean-room environment to ensure high purity bacterial cultures. Each batch of Symprove® is analyzed by an independent lab to verify the identity of the bacterial formula and potency of 10 billion CFU’s per 50 ml serving (the upper recommended daily dose). These high standards for purity, identity, and potency satisfy Criterion 3.

serving can be measured in the cup provided and should be taken every morning on an empty stomach, 10 minutes before eating or drinking. Those experiencing GI symptoms are likely to see relief within four weeks, but it is recommended to use for a full 12 weeks to gain maximum benefits and rebalance gut bacteria. After 12 weeks, Symprove® may continue to be taken as part of a maintenance program.


We’ve seen that Symprove® meets the three required criteria for a superior probiotic supplement; it is a scientifically validated, clinically-proven, and quality-tested product that supports a balanced and robust population of gut flora to ensure the health of your GI system and your overall health. Clearly anyone with IBS will, after seeing the results of the British clinical study, want to try a 12-week course of Symprove for themselves. But also, for those with general GI issues and even for those without- who wish to promote optimal health, or counteract a course of antibiotics, Symprove® is the probiotic of choice.


1. Sanders ME. Probiotics: definition, sources, selection, and uses. Clin Infect Dis. 2008 Feb 1;46 Suppl 2:S58-61; discussion S144-51. 2. Fredua-Agyeman M, Gaisford S. Benef Microbes. Comparative survival of commercial probiotic formulations: tests in biorelevant gastric fluids and real-time measurements using microcalorimetry. 2015 Mar;6(1):141-51. 3. Sisson G, Ayis S, Sherwood RA, Bjarnason I. Randomised clinical trial: A liquid multi-strain probiotic vs. placebo in the irritable bowel syndrome--a 12 week double-blind study. Aliment Pharmacol Ther. 2014 Jul;40(1):51-62.

How to Use Symprove®

Symprove® is available in a four-week pack containing four bottles. Each 50-ml • Order hotline: 1-866-800-4677 • e-mail:



Proven Relief for IBS

ARRIVE 100% of Symprove live bacteria are delivered live and active.

SURVIVE 100% of Symprove live bacteria survive stomach acid.

THRIVE 100% of Symprove live bacteria reach the gut, where they can thrive.

SPECIAL OFFER for a limited time we are waiving the $10 surcharge to ship this product.*

1 month supply 4 x 500ml $124.99 *Offer valid until August 31st 2015

*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

Research by University College London shows Symprove Arrives, Survives and Thrives in targeted areas of your gut quickly and effectively.

UPDATING THE CALORIE RESTRICTION MIMETICS BY MARIOS KYRIAZIS M.D. When I first started writing about Calorie Restriction Mimetics (CRMs) 10 years ago, research in this area was at its infancy. Now however, several CRMs are well-known and relatively well-accepted agents which imitate the effects of calorie restriction itself. I highlight the fact that these compounds are not merely pills for those who are too lazy to diet, but may be used (under medical

supervision) in association with a healthy lifestyle to experience certain benefits which are generally associated with calorie restriction. It is, of course, well-known that calorie restriction can have a host of benefits and has been shown to extend lifespans in several laboratory animals. The effects of calorie restriction can be divided into: • Genetic (it regulates genes OH












Figure 1. Rapamycin and resveratrol: Putative dietary restriction mimetics. Resveratrol is a compound found in red wine that has been suggested to recapitulate some aspects of dietary restriction (DR), perhaps by activating sirtuin-family enzymes. Rapamycin is a specific inhibitor of the target of rapamycin (TOR) kinase. TOR activity is reduced by DR and inhibition of TOR is sufficient to increase life span in invertebrate organisms.

such as Sir-2, Daf-16 and p53, all of which have direct impact on age-related mechanisms). • Biochemical (positively affecting DHEA, inflammation response, nerve growth factors, and mitochondrial function, among others). • Physical (reduction of cholesterol, lipids, improvement of memory, and body weight, etc). There are many other effects of calorie restriction. If any compounds are able to mimic some of these effects, then these can be considered as CRMs. In a paper I wrote back in 2009, I suggested that if a compound can mimic at least two biochemical plus one genetic, or five biochemical/physical effects of calorie restriction, then this compound is classified as a CRM (1). There are many available CRMs used in research and the clinic. Here I will mention the latest research supporting some principal CRMs: Resveratrol The action of resveratrol in activating the SIRT family of genes is well-documented. As

a result of this action, there is an overall reduction of the risk of age-related degeneration. Calorie restriction, too, affects this family of genes, as mentioned above. In a representative experiment, scientists compared the effects of calorie restriction to the effects of resveratrol in lemurs. Both interventions reduced oxidative damage in the long term. Interestingly, both interventions increased oxidative stress in the very short term, which is an indication that both act through a hormetic effect, which means that the interventions stimulate the organism to begin the repair process by being slightly stressful. This is a typical example of how CRM and other agents can act in order to initiate the beneficial process: by causing mild damage, just enough to awaken the repair process (2). Resveratrol is an inhibitor of mTOR, and it has been used in association with rapamycin (see figure 1) where it was found to have anti-cancer effects (3). Oxaloacetate I have discussed this compound in other articles about exercise mimetics (see IAS website) and mTOR inhib- • Order hotline: 1-866-800-4677 • e-mail:


“(Our) results demonstrate... a tractable means of introducing the health-related benefits of dietary restriction.” itors (see Aging Matters™ Magazine, issue 3 2015). However, it is worth noting that oxaloacetate increases energy production by the mitochondria, regulates fat tissue production and improves endurance. In a study in mice, administration of oxaloacetate for two weeks had an effect on mTOR, (which is implicated in aging), reduced inflammatory markers and improved brain metabolism. It also activated the insulin signalling pathway and improved formation of new neurons. Many of these characteristics are also shared by calorie restriction itself, indicating that oxaloacetate can be considered as a typical CRM (4). Oxaloacetate works by mod-

ulating several age-related genes and factors, which are also modulated by calorie restriction (5). The most important of these are the FOXO/ DAF-16 factors, and AMPA protein kinase, which is involved in energy production (see figure 2). The authors of this study concluded: “(Our) results demonstrate that supplementation of the citric acid cycle metabolite, oxaloacetate, influences a longevity pathway, and suggest a tractable means of introducing the health-related benefits of dietary restriction.” Finally, although not strictly a CRM action, it is worth mentioning the relationship between oxaloacetate and glioblastoma therapy. Calorie restriction can help in reducing the general risk of cancer,

and it seems that oxaloacetate may have this general property. It was shown that oxaloacetate may boost the effects of chemotherapy in cases of glioblastoma (a type of brain cancer). But it appears that the benefits of oxaloacetate may also be applicable in other tumours. The enzyme ATP citrate lyase helps convert citrate into oxaloacetic acid, and, through various mechanisms, reduces inflammation and lipid metabolism in cases of cancer (6). Metformin Metformin is a drug used in diabetes, but it has several other benefits. It is a receptor sensitizer (i.e. it improves the sensitivity of insulin receptors on the surface of muscle and fat cells). Importantly, metformin regulates the


Reduced levels of Insulin and IGF-1



Absence of Glucose



Enhanced NAD+ concentration

Deoxyglucose This is one of the first CRMs described over 16 years ago. It inhibits glycolysis and mimics some of the effects of CR, particularly increased insulin sensitivity, reduced glucose levels, and other biochemical changes. Although using high doses of deoxyglucose can be toxic, research shows that low doses are effective, and it is still used in experiments (8). Other calorie restriction mimetics include the anti-obesity drugs Olbetam and Rimonabant, the anti-diabetes drug exenatide, the natural plant extracts called gugulipids, the compound Naloxone, and the anti-glycating compounds aminoguanidine and carnosine.




expression of genes which are involved in free radical damage to the liver. Studies show that metformin regulates the insulin/IGF-1 signalling pathway which is one of the most important during aging (7). Calorie restriction itself is a modulator of this pathway. • Order hotline: 1-866-800-4677 • e-mail:

Figure 2: Different biochemical pathways involving steps where CRM may act upon. In this article, I discuss agents which act on SIRT1, AMPK and mTOR elements.



Percentage of animals without age-related disease



Control CR

Cardiovascular Disease

Control CR







Glucoregulatory impairment 5




Age (years)


Control CR 5







Age (years) 30



Figure 3: A comparison of control animals (in blue) and calorie restricted animals (in red), shows a general increase in lifespan during calorie restriction. Image credit:

Just to show that there is a huge number of possible CRM under investigation; see this list of some of the most representative examples: • Iodoacetate • 4-phenylbutyrate (PBA) • DPP-4 inhibitors • Peptide PYY3-36 • Modulators of Neuropeptide Y • Adiponectin • Hydroxycitrate • Gymnemoside • The mTOR inhibitor Rapamycin, and related agents • Galanin antagonists • Aldifen (2,4-Dinitrophenol) • Acarbose

Conclusions It is quite clear that calorie restriction can extend health span (see figure 3). However, when it comes to pharmacological interventions, it is quite impossible for any single CRM to imitate every single benefit of calorie restriction. This means that CRMs need to be used in combination for maximum effectiveness in a wider sense. While many CRMs remain experimental, some are available for everyday clinical use, under medical supervision. Examples include; metformin, oxaloacetate, resveratrol, carnosine, aminoguanidine, Acarbose, and some of the mTOR modulators. These agents modify biochemical and physical parameters which are beneficial, overall, in reducing the impact of certain age-related conditions. However, the importance of pleasant exercise, a healthy

lifestyle and an adequate nutritional programme remain essential. This is because benefits from all these domains are integrated and become much more effective in the long term. References 1. Kyriazis M. Calorie Restriction Mimetics: examples and mode of

Pathway, Reduces Inflammation, and Stimulates Neurogenesis. Human Molecular Genetics. 07/2014; DOI: 10.1093/hmg/ddu371 5. Williams DS, Cash A, Hamadani L, Diemer T. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging cell. 2009;8(6):765-768

action. Open Longevity Science

6. Khwairakpam AD, et al. ATP

2009, 3;17-21

Citrate Lyase (ACLY): A Promising

2. Marchal J et al. Calorie restriction and resveratrol supplementation prevent age-related DNA

Target for Cancer Prevention and Treatment. Curr Drug Targets. 2015;16(2):156-63

and RNA oxidative damage in a

7. Anisimov VN et al. Gender

non-human primate. Exp Gerontol.

differences in metformin effect on

2013 Sep;48(9):992-1000

aging, life span and spontaneous

3. Alayev A, Berger SM, Kramer MY, Schwartz NS, Holz MK.The combi-

tumorigenesis in 129/Sv mice. Aging (Albany NY). 2010 Dec;2(12):945-58

nation of rapamycin and resveratrol

8. Ingram DK, Roth GS. Calorie

blocks autophagy and induces

restriction mimetics: Can you have

apoptosis in breast cancer cells.J Cell

your cake and eat it, too? Ageing Res

Biochem. 2015 Mar;116(3):450-7

Rev. 2015 Mar;20C:46-62

4. Wilkins HM et al. Oxaloacetate Activates Brain Mitochondrial Biogenesis, Enhances the Insulin • Order hotline: 1-866-800-4677 • e-mail:



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Aging, Muscles & Exercise By Dr. Richard Lippman

died much more readily than did couch potato Dear antiaging fans, here is something for you to consider the next time you pound your Nikes on the Danes! On the other hand, moderate joggers did better than couch potatoes. High-mileage runners pavement. A Copenhagen Health Study followed 5,000 Danes for approximately twelve years (1). Their were defined as those who ran faster than seven mph for more than 2.5 hours a week. results showed that Danish high-mileage runners • Order hotline: 1-866-800-4677 • e-mail:


“This comprehensive Danish study poses a critical question: Why is heavy or extensive running bad for our health?” Lead Danish researcher, Professor Peter Schnohr of the Frederiksberg Hospital in Copenhagen, wrote; “Longterm excessive exercise may be associated with coronary artery calcification, diastolic dysfunction, and large artery wall stiffening.” (Figure one). I have measured these adverse effects with International Antiaging Systems’ (IAS) new BioCuff™, which was unfortunately not available to Prof. Schnohrol. Moreover, ‘diastolic dysfunction’ can often be corrected by balancing your hormones with Armour™ thyroid, vasopressin (Vaso-Pro™), oxytocin (Oxy-Pro™), and IAS’s newest development, aldosterone (Aldo-Spray™).

A Critical Question This comprehensive Danish study poses a critical question: Why is heavy or extensive running bad for our health? Medical research has no definitive answers to this basic question. However, I have a theory, first revealed in my 2009 book Stay 40 (2). In my book, I stated emphatically that very heavy exercise causes a cascade of free radicals eight times the norm and this cascade overwhelms all our defense systems. What I mean is that during couch-potato resting, oxygen entering our lungs is easily handled by our bodies’ lines of defense, especially our antioxidant enzymes, catalase and SOD (superoxide dis-

mutase). These two enzymes easily eliminate oxygen-generated free radicals. Indeed, our free-radical lines of defense can dismutate (render harmless) double the amount of free radicals that are generated at rest. However, when we exercise excessively--as in the case of high-mileage running--our oxygen-generated free radicals are approximately eight times those produced by couch-potato respiration. Thus, our defenses are overwhelmed and damage occurs to our cells and DNA.

sex hormones (testosterone and estradiol), as well as key upstream repair hormones such as growth hormone and IGF-1. However, in people over the age of forty, peptides and hormone deficiencies and imbalances do not promote cell and DNA repair by free radicals. This is my key thesis explained in detail in Stay 40 (2). I also propose that rapid aging is caused by the use of excessive quantities of alcohol and drugs, both legal and illegal.

In truth, for people in their teens or twenties, this radical damage is often quickly repaired by a robust hormone system containing high and balanced amounts of

If you doubt these statements, consider the enclosed before-and-after photos of older people who exercised heavily for a period of eleven months without consuming free-radi-

Figure 1: Danish research highlights that overly intensive exercise is detrimental to health and may accelerate aging.





413 576 262 40

128 7 8 2


394 570 252 36

120 7 8 2



Adjusted for age and sex Sedentary nonjogger (reference) Light jogger Moderate jogger Strenuous jogger Adjusted for age, sex, smoking, alcohol intake, edcuation and diabetes. Sedentary nonjogger (reference) Light jogger Moderate jogger Strenuous jogger Schnohr, P. et al. J Am Coli Cardiol. 2015; 65(S):411-9.





Hazard Ratio 16 • Order hotline: 1-866-800-4677 • e-mail:



Figure 2: Before-and-after photos of older people who exercised heavily for a period of eleven months. Whilst their bodies look fitter, examine their faces/heads closely.

cal scavengers (see figure two). Notice that although these older people have apparently benefitted from heavy exercise, as demonstrated by their improved muscle mass and definition and simultaneous loss of body fat, these benefits appear to have been achieved at the expense of rapid aging of their faces and graying of their hair! If they had taken optimum amounts of free-radical scavengers as contained in ACF228™, the effects of heavy exercise would less likely have caused age-related damage to their faces and hair. Alternatively, these people should have balanced their hormone output to reflect that of young people in their twenties and thirties. Balanced hormone output

usually means consuming daily the above-mentioned sex hormones and key upstream hormones, as well as corrective amounts of thyroid and adrenal hormones (Armour™ thyroid and hydrocortisone).

Aging and Speed I believe that heavy exercise in older people merely speeds up the process of aging. The same effect is experienced in people young-or-old who use methamphetamine. This illicit drug (‘speed’) will indeed hasten aging and physical deterioration. I have measured free radicals in intravenous speed users, using near-infrared spectroscopy, and determined that the highest levels of free-radical metabolites, namely lipid peroxides, occur when speed is injected

into the arm (2). In addition, I recommend avoiding most synthetic pharmaceutical stimulants, which, like speed, may encourage rapid aging. I believe these legal drugs should only be used in cases of emergency or dire need, because they are the fourth leading case of death in the USA. (3)

False Impressions about Diet, Exercise and Aging On February 12, 2015, the Diabetes and Endocrinology section of the Lancet published a study about a widespread misconception concerning diet, exercise and aging in the United States. Professor Christopher N. Ochner and his colleagues from Mt. Sinai Hospital, Colorado, stated that Americans wrongly believe that weight

loss can be achieved merely from diet and exercise. On the contrary, he stated, “Once obesity is established, however, body weight seems to become biologically ‘stamped in’ and defended.” He further said, “The average adult with sustained obesity has less than a 1 percent chance of re-attaining and maintaining a healthy body weight without surgery.” This ‘stamped in’ effect is largely caused by free radicals that slow our metabolism, and decreasing amounts of hormones that prevent us from efficiently burning the calories we consume.

Other Types of Stiffening As stated previously by Prof. Schnohr, excessive exercise can cause arterial stiffening. • Order hotline: 1-866-800-4677 • e-mail:


“I found that the Russian ‘muscle’ peptide bioregulator ‘Gotratix®’ helped significantly with my muscle pain and flexibility after exercising.” During aging, another type of stiffening is the stiffening of our muscles. You may ask, “What exactly do you mean by ‘muscle stiffening’?” Allow me to pose some questions: Have you ever seen the backs of two men, aged twenty and eighty, walking away from you at a great distance— say fifty yards or more? If so, which one of them is twenty and which is eighty? Of course, the answer is that the eighty-year-old walks with a stiff gait not seen in the twenty-year-old. This difference in gait becomes increasingly apparent as a person grows older. Indeed, according to the Los Angeles Gerontology Research Group, eventually no one can walk who is over the age of 110 years (4).

Thus, avoiding walking with an increasingly stiff gait is important to everyone interested in aging and in doing something about one’s aging. I have often pondered how I could improve my gait during aging. I am faced with the hard reality of an increasingly rickety gait in my senior years until, if I live to be 110 years old, I will eventually end up in a wheelchair. Then I discovered some special peptides developed for elite Russian troops during the Cold War. I read that these special peptides are made today in Denmark by a patented extraction method. After three days of oral application, these special proteins added spring to my gait and flexibility to my ag-

ing muscles and body. I have mentioned several of these peptides previously in this article and in other articles I have written (4). Interestingly, I found that the Russian ‘muscle’ peptide bioregulator ‘Gotratix®’ helped significantly with my muscle pain and flexibility after exercising. Indeed, pain and stiffness were nearly eliminated after only three days of use. In fact, I found myself refreshed with new vigor and agility. On the negative side, I needed greater focus on the motion and coordination of my legs because I was not used to such newly realized muscle speed, balance and poise.

total of twenty days. I also took the same amount of the brain peptide ‘Cerluten®’ (5), which I believe complements Gotratix® by better coordinating the brain with the actions of the muscles. With these extensively tested Russian peptide bioregulators, I hope to avoid the rickety walk of other eighty-yearolds and perhaps avoid ending my days in a wheelchair.

I began by taking two capsules the first day and then one capsule thereafter for a

References (1) Schnohr, P. et al. 2015. “Dose of Jogging and Long-Term Mortality. The Copenhagen City Heart Study,” J. Am. Coll. Cardiol. 65(5), 411–419. (2) Lippman, R. 2009, Stay 40, Outskirts Press Inc., Boulder, Colorado. (3) (4) Personal email communication (5) English language translation of Russian clinical trials with peptide bioregulators can be read here: a. b. c. d. e. f. g. h.

18 • Order hotline: 1-866-800-4677 • e-mail:

Peptide Bioregulator Testimonials “I have multiple health problems and thanks to the use

“I can tell you that Visoluten® for the eyes was like a mir-

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the rest of her life. It gave her back her sight.” MM

greatly alleviate them. I have atrial fibrillation, ankylosing spondylitis (arthritic disease), chronic pain syndrome (degenerating discs), kidney stones, chronic diarrhea from a (discontinued) heart medication, burned-out adrenals from prostate cancer treatments, depression (surprise!). Using the peptides, I started with a single packet of each. After a concussion I used a second package for the brain. With the circulation peptide, I noticed in a few days that I had warmer hands and feet, and no more angina when doing heavy activities! My intestinal problems stopped. My cardiac rhythm is much less affected by palpitations and (no more) tachycardia. My eyesight has definitely improved, considering I’ve had multiple retinal detachments in both eyes, my retinal

“I’ve found them to be highly effective. I have had bronchiectasis since I was 2 years old. I also have lone permanent atrial fibrillation. I took three together, pineal, heart and circulation. By the third day I had feeling returning to my feet, which are always swollen with edema. I have also noticed that I am breathing much easier with much less fluid collecting in my lungs. As well my muscle responses to moving are much sharper as well as an improvement in my sight. My eyes also improved, surprisingly, probably from the circulation. These are amazing new options for people to maintain their health. Thank you.” GK

surgeon finds it ‘miraculous’ that I can see at all with all the scars and tears from surgery. Now I’ll have to change

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years and now they are gone. The only thing I can think

I am now about to embark on intensive therapy (3 boxes/

of is that the peptide cleared them up. Great.” LM

month) to really improve some of the functions that were the most damaged/limited. What a wonderful feeling to be able to take back your health! Thanks so much to IAS for bringing these products to us. VERY GRATEFULLY YOURS.” WK

“I purchased the Testoluten• peptide complex. I started taking it right after a blood draw for getting my testosterone level checked. That test gave me a reading of 586ng/dl. After taking the product 2 per day for 10 days, I waited a week and had another blood draw to

“We have waited 11 years to hear our [autistic] son speak, and after the one month use of Cerluten•, he is

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showing great promise.” DJ • Order hotline: 1-866-800-4677 • e-mail:


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Offer: ONLY $60 per pack when you buy 3 or more See for much more information *Offers valid until August 31st 2015 *Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

Dr Ward Dean Answers your questions We are delighted that Ward Dean M.D., one of the world’s foremost antiaging physicians, has agreed to answer our readers’ questions. Full details about Dr. Dean can be seen at his website:

Dear Dr. Dean, Q. I recently heard a wellknown antiaging physician say that he often sees rises in cortisol levels when a man consumes pregnenolone; as I use 100mg of pregnenolone regularly I find that rather disconcerting. May I ask you what has been your experience?

Figure 1: The hormone cascade starts with cholesterol and then pregnenolone.

Steroidal Hormone Principal Pathways Illustrating the chronic stress response/pregnenolone steal Vitamin B5 (Pantothenic Acid)

Acetyl CoA Cholesterol



17α- Hydroxylation

17 - Hydropregnenolone

17 - Hydroxyprogesterone

As you can see from the accompanying figure 1, pregnenolone holds a premier position in the hormone cascade, and can be converted into virtually all of the steroid hormones, depending on the body’s needs (Fig. 1). The pathway has a “right side” and a “left side”. The right side includes pregnenolone > DHEA > Testosterone and the estrogens. The left side involves pregnenolone > progesterone > cortisol and progesterone >

Cholestryl Sulfate

Circulating LDLs

J.W., Washington A. Dear JW,

Dietary FATS


21 - Hydroxylation 11 - Deoxycorticosterone

11 - Deoxycortisol


11β - Hydroxylation CORTISOL


5α - Dihydrotestosterone

19 - Hydroxytestosterone


16α - Hydroxy DHEA Androstenedione 19 - Hydroxyandrostenedione




Copyright (C)2008 Functional Diagnostic Nutrition

Pregnenolone Steal =

aldosterone. During times of severe or prolonged stress, pregnenolone may be diverted from the right side of the pathway in order to feed the left side

Estradiol - 17α

of the pathway, resulting in elevated cortisol in response to the stress. This is known as the “pregnenolone steal” syndrome, as shown at the bottom of figure 1. Conse-

DHEA Sulfate

Estradiol - 17β

16α - Hydroxyandrostenedione 16α 19 - Dihydroxyandrostenedione 16α - Hydrosyestrone


quently, DHEA production suffers because less pregnenolone is available for the right side of the pathway, throwing the cortisol/DHEA ratio out of balance. • Order hotline: 1-866-800-4677 • e-mail:


Women aged 10–70 years Men aged 4–79 years

400 350 250 200 150 100 50














Age Group [years] The problem is not due to pregnenolone supplementation, but to the stress. If one’s cortisol is rising (due to stress), then I recommend continuing to take pregnenolone and balancing it with additional DHEA. This can restore a normal cortisol/ DHEA balance, which will help the body to deal with the stress. Thus, it’s not the pregnenolone that’s driving the cortisol—it’s the stress. For example, in a recent study of the effect of pregnenolone on schizophrenia, doses of pregnenolone were titrated up to 500 mg/day for four weeks in 18 schizophrenics. Although treatment with pregnenolone resulted in fourfold elevation in serum levels of pregnenolone, tripled serum pregnenolone sulfate levels and increased the GABAergic neurosteroid allopregnanolone fivefold, plus DHEA-S levels by approximately 16%, treatment with pregnenolone did not increase serum testosterone, free testosterone, cortisol, DHEA, estradiol, or androstenedione levels. (1) Pregnenolone, like DHEA, 22

Figure 2: Age and sex differences of pregnenolone sulfate in the serum of 230 women aged 10–70 years (empty circles) and 179 men aged 4–79 years (solid circles). (2)



Pregnenolone sulfate [nmol/L]


drops precipitously with increasing age (Fig. 2), and should be routinely supplemented. The usual dose in aging men and women is 2550 mg per day, although more or less is commonly taken, based on individual need. I hope this answers your question and relieves your stress. Ward Dean, M.D. References: Marx CE, Richard Keefe RSE, Robert W Buchanan RW, et al. Proof-ofConcept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia. Neuropsychopharmacology. 2009; 34(8): 1885–1903. doi: 10.1038/npp.2009.26 Havlíková H, Hill M, Hampl R, and Stárka L. Sex- and Age-Related Changes in Epitestosterone in Relation to Pregnenolone Sulfate and Testosterone in Normal Subjects. The Journal of Clinical Endocrinology & Metabolism. 2002;87(5): 1925–2413. DOI: http://dx.doi. org/10.1210/jcem.87.5.8499

Dear Dr. Dean, I went and saw a sleep doctor and he prescribed trazodone 50 mg. It did nothing at 50 mg but at 75 mg it seemed to give me about 3 hours of sleep, in

fact it felt a lot like Benadryl®. However, I am having great difficulty in sleeping and this minimal amount is making me feel like a basket case! Can you please make a suggestion that can improve my situation? M.W., California Dear M.W., First, although I know that trazadone is commonly recommended by many physicians, I believe it is ineffective as a sleep inducer (a somnificant). I preferentially use Gabapentin (Neurontin) for insomnia. Gabapentin is an analog of GHB (gamma-hydroxy-butyrate) and shares many of GHB’s sleep-inducing benefits. For example, it enhances sleep quality, increases slow wave sleep and decreases spontaneous arousal.(1) I suspect it enhances all four phases of sleep, as does GHB. Interestingly, there has been a review of gabapentin as a sleep-inducer, compared to trazadone.(2) Patients who received gabapentin • Order hotline: 1-866-800-4677 • e-mail:

improved significantly more than did patients who received trazodone, and gabapentin-treated patients were less likely than trazodone-treated patients to have initial insomnia and to awaken in the morning feeling tired and worn out. In my experience, gabapentin is effective for most people at a dose of 600-800 mg at bedtime. Some people are very sensitive and do well on even less; others are resistant and need higher doses (I have a few patients on 1800-2400 mg). Fortunately, gabapentin does not interact adversely with other drugs, has few adverse side effects (sleepiness is the most common) and wears off rapidly (just like GHB), usually snapping people awake in the morning, without any hangover. Another advantage is that gabapentin is not a controlled drug like GHB. Ward Dean, MD References: Lo HS, Yang CM, Lo HG, Lee CY, Ting H, Tzang BS. Treatment effects of gabapentin for primary insomnia. Clin Neuropharmacol. 2010 MarApr; 33(2):84-90. Karam-Hage M, and Kirk J. Brower KJ. Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients. Psychiatry and Clinical Neurosciences. 2003 October;57(5): 542–544. October 2003 DOI: 10.1046/j.14401819.2003.01161.

[Ed. – the brand name of gabapentin is Neurontin®]

12th Annual Anti Ageing Conference London, England October 15-17, 2015

Contact Information: Anti Ageing Conference London 38 Regent Street on the River William Morris Way London SW6 2UT, United Kingdom Tel: +44 (0)79 7317 3478 Fax: +44 (0)20 7491 0410 Email:


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PEO-Pro 120 Capsules $39.99 Special introductory offer save $5.00 per pack (Until August 31st 2015) *Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.


A B R E AK THROUG H FOR C ATAR AC T Can-C™ eye-drops are the original™ brand- developed by Innovative Vision Products (IVP). This group were the first to research, publish and prove how eye-drops can reduce and even eradicate cataract. Accordingly there are active US and EU patents (and others pending) on this unique and special product. Unique formula:

Clinical trial:

Improving eye-sight:

Can-C™ eye-drops are the formula from the original published human trials. They contain a purified and racemized form of n-acetylcarnosine (made in Japan); this natural di-peptide has potent anti-glycating and antioxidant properties that prevents lipid peroxidation. Note that the formula is important- it’s not all about the n-acetylcarnosine; the specific carrier agents and their purity are also important. If you look at the Can-C™ formula you will see differences to the copycats, (remember it is only Can-C™ that is patented in recognition of the original work). If you want the best possible results in the fastest possible time, then choose Can-C™ to deliver them according to the clinical trials.

Patients placed two-drops of Can-C™ into their eyes twice daily for a 6-month period, the outcome was:

More evidence is mounting that Can-C™ is efficacious for many conditions including:

• 90% saw an improvement

in their visual acuity. • 88.9% of patients showed improvement in the clarity of their lens. There have been numerous reports of cataract shrinkage and even disappearance with documented evidence that Can-C™ eye-drops remain effective (and safe) more than 24-months later. The most commonly expressed initial reports are that glare is significantly improved, (for example night driving is much safer) and color perception is enhanced.

• Cataracts (particularly the senile version) • Glaucoma • Presbyopia • Corneal disorders • Eye strain • Ocular inflammation • Blurred vision • Vitreous opacities and lesions • Diabetes mellitus complications • Contact lens users • Dry eye syndrome Of special interest may be to persons who wear contact lenses. This is because Can-C™ inhibits the accumulation of lactic acid and therefore contacts can be worn for longer periods without pain.


We have also received reports that Can-C™ not only aids dry-eye syndrome with its lubricants, but that Can-C™ helps to unclog proteins from the lacrimal ducts, thus releasing more natural tears onto the eye. In a similar way, it is also believed that the unclogging of proteins in the eye’s drain, (the Schlemm valve), helps to reduce intraocular pressure and thus aids glaucoma.

Above: Can-C Plus capsules


Right: A woman’s eye shows the cataract before treatment. Far Right: 5-months later after use of Can-C eye-drops (two drops twice daily), there is no longer a visible cataract and eyesight has improved.

Dr. Kyriazis book, ‘The Cataract Cure’, details the usefulness and evidence of Can-C™ eye-drops. It is now available as a FREE e-book at: • Order hotline: 1-866-800-4677 • e-mail:


SPOTLIGHT: GHRPS A R E AL ‘OR AL’ ALTER NATIVE TO G H INJEC TION S Ever since Dr. Rudman’s work in the 1980s and then the release of Dr. Klatz’s book ‘grow young with HGH’ in the 1990s, there has been a strong interest in the use of growth hormone (GH) in antiaging medicine. Dr. Rudman’s research concluded that after injecting his elderly patients with GH, many of them had reversals of their biological age markers by as much as 20-years; specifically having noted improved skin, hair, muscle mass, decreased fat levels and enhanced levels of stamina, strength and well-being. It’s not entirely surprising given the multi-faceted role of growth hormone, plus as its name suggests it is involved in the growth and repair of tissues, but unfortunately blood levels of it decline dramatically past the age of 35 (see figure 1), despite the fact that there is evidence that the pituitary gland continues making significant amounts of it.

GH injections

The issue with injecting GH, (brand names include Genotropin®, Saizen® and Zomacton®), other than its expense, is that it does have to be injected to be effective, this is because as a 191 chain amino-acid it simply can’t be absorbed via any other route, thus daily injections can become a chore. Furthermore, many countries have decided that GH injections be classified as a controlled substance, partly because of its anabolic actions. Controlled substances often require special import and export licenses; this is overand-above the requirement for a prescription. Furthermore, the research of Dr. Richard Walker has highlighted that bolus injections of GH are not


bioidentical and that as they induce spikes of GH into the blood they could end up damaging the pituitary gland, leading to a down-regulation of its own production of GH, or even to stop GH production altogether.


But meanwhile, Dr. Walker’s research has shown that the use of GHRPs, (growth hormone releasing peptides) have a much safer profi le whilst enjoying the same benefitseven if they provide them a little more slowly. We would recommend that you read his extensive article in the Aging Matters™ magazine, No3, 2014 to understand fully how they operate. What we can say is that GHRPs, (GHRP2, GHRP6 and sermorelin) have the following benefits: • They can be sublingually, intra-nasally and even orally, passing into blood and thus avoiding the need for needles. • Their feedback loop means that they cannot cause the pituitary to down-regulate. • GHRPs are not controlled substances. • Rather than inducing a spike of GH in the blood, GHRPs augment (improve) each release of GH naturally into the blood, for which there are several peaks daily, (although the rising from bed peak is the highest one) - see figure 2.


Sermorelin is actually the precursor to GH, being the first 29 amino acids and is

applied via the sublingual route. Sermorelin’s function may be to release existing stores of GH from the pituitary- rather than encourage more production as a pure agonist would. Dr. Walker has highlighted that combining sermorelin with GHRP2 or GHRP6 has a highly synergistic effect, in some cases eliciting up to a 5x greater quantity of GH into blood, an action that can be equivocated to using injectable GH itself. Note: You can also hear Dr. Walker discuss this with us on the IAS video page.


There is no definitive answer yet as to the specific differences between GHRP2 and GHRP6; our own experiences, including information received from physicians and patients who use these products suggests the following: • GHRP6 may induce more hunger feelings than GHRP2 and could improve levels of IGF-1 more. Therefore this option may be better recommend for those Figure 1 (top): The typical GH levels in blood with age, note that ‘geriatric’ levels are reached as early as during the 30’s. Figure 2 (middle) shows the 24 hour profile of subcutaneous (and also intravenous) GH. Compare that to figure 3 (bottom), the natural peaks of GH in both young and elderly patients. Only GHRPs naturally amplify these bioidentical patterns. • Order hotline: 1-866-800-4677 • e-mail:

who want to put on muscle mass. • GHRP2 may create less hunger feelings and therefore could be preferable to those who want to stimulate GH for fat loss. Also as the GHRP6 (Releasing-Pro™) is a nasal spray, those who don’t like that feeling may prefer GHRP2-Pro™ since it is an oral liquid simply swallowed.


GHRPs have created a genuine efficacious alternative; they are simpler/ easier to use and at the same time they have a better/ safer profi le than injectable GH.

SPOTLIGHT: THYROID SUPPORT FOR THE HYPOTHYROID EPIDEMIC Dr. Broda Barnes in the 1970s estimated that 40% of the adult population was deficient in thyroid hormones; he published this statement in his excellent book‘hypothyroidism, the unsuspected epidemic.’ Since then, pupils of Dr. Barnes, such as Dr. Richard Wilkinson, have suggested that this figure could be even greater now! This is important because the thyroid gland is of pivotal importance to our overall health, but like the majority of hormones as we age the production of thyroid hormones decline. This lack of thyroid function is the root cause of a wide variety of agerelated health disorders. Ergo, supplementation with a synthetic or a natural thyroid can have a significant positive effect on a wide range of age-related problems.

The importance of the thyroid gland The hormones produced by the thyroid control the body’s metabolism- the rate at which it burns calories for energy. It also controls the body’s utilization of fat, so a decline in the secretion of hormones from the thyroid gland, (known as hypothyroidism) can result in wide range of symptoms such as poor concentration, confusion, memory problems, cold hands and feet and weight gain. Another serious condition which can be caused by and result from an underactive thyroid are painful musculoskeletal issues that affect tendons, muscles and ligaments.

How can I be sure if I need a thyroid supplement? Above: The position of the thyroid gland

thyroid checked, but another, simpler method is to take your body temperature when you wake in the morning. It should be in the range of 97.8 to 98.2 degrees Fahrenheit, if it is regularly lower you could be hypothyroid and if higher then hyper-thyroid.

Choosing between synthetic and natural thyroid supplements IAS stocks a comprehensive range of both synthetic and natural thyroids, although we advocate the use of a natural supplement over a synthetic, this is because products such as Armour® are of a porcine origin, so they naturally contain the full spectrum of T1, T2, T3 and T4 thyroid hormones, (note the bottles only list the amounts of T3 and T4 because very few physicians are familiar with T1 and T2).

Thyroid doses Natural desiccated thyroids are measured in grains; with one grain being equivalent to approximately 60 mg. IAS carries doses from ¼ grain to 2 grains, with brands including Armour®, ERFA® and Nature®. IAS also provides synthetic T3 in 20 mcg and T4 in 100 mcg tablets.

Thyroid supplements provide potent antiaging protection Many aging individual can benefit from taking a thyroid supplement because this remarkable hormone has such a profound affect across so many different conditions. Many antiaging physicians consider thyroid support an essential part of any serious attempt to improve a person’s healthspan and longevity.

Apart from recognising the types of effects listed above, your doctor can of course get your blood levels of

Conversion between synthetic and natural thyroid products The table provided is a helpful guide to what the suggested conversion rates are for those wishing to make the switch between synthetic thyroids and natural versions. As always we recommend consulting with a physician before making changes to your program.

Dose of Desiccated thyroid (grains)

Equivalents (mg)

Dose of T3 (lithyronine) (mcg)

Dose of T4 (levothyroxine) (mcg)
























500 • Order hotline: 1-866-800-4677 • e-mail:




S U PPLYING AND BAL ANCING OMEGA S NATU R ALLY Most people are familiar with the benefits of omega oils for their health and in particular to reduce inflammation. Indeed cod-liver oil supplements are the world’s most popular supplement, but recently Professor Brian Peskin’s research which is all contained in his new book – the PEO solution - is causing quite a stir and may make many folks to rethink and change their stance. We fully appreciate that a change in direction/ thinking often takes time to get used to.

Professor Brian Peskin and the cover of his latest book - the PEO solution

What are we talking about? We are referring to his discovery that the body naturally uses plant oils to make its own omega 3 and 6, thereby satisfying a precise balance according to needproviding the ‘raw materials’ are available. Professor Peskin has termed the phrase PEO as the acronym for ‘parent essential oils.’ Professor Peskin states openly that he has found this information hidden in the scientific literature and never once found it referred to in the medical literature. Why does it matter? Because as he says, it means that physicians are unaware of these facts and therefore they continue to advocate super-physiological doses of omegas from fish oil, which may be actually doing

more harm than good! It’s a lot to swallow, (no pun intended) and we can’t do his research justice on a single page, which is why we recommend his book, or take a look at the Aging Matters™ magazine No1, 2015 in which Professor Peskin’s article is the lead story. But right now, let’s highlight some of the advantages of the PEO source for omega 3 and 6: • The plant oils live in our environment, (typically around 50-60°F); hence they do not go rancid at room temperature. Cold water fish live in a cold environment (typically around 30-40°F), therefore PEOs represent a much more stable product being unlikely to ‘go off ’ and become rancid and hence pro-inflammatory. • The PEOs are obviously a nonanimal source and therefore can be considered more suitable for those wanting to avoid animal sourced/ based products. • The PEOs represent a sustainable source, since there is already too much ‘pressure’ on the seas to provide both fish and even krill stocks.

How is fish oil made? It often does not start as the healthiest possible source!


• The PEOs enable the body to produce its own internal essential fatty acids (EFAs) and correct its own balance. This has not been shown to be the case with fish oil supplements.

Why not fish oil?





EFAs work like tiny “magnets” drawing oxygen into all cells, tissues and vital organs.

O But could there be Reduce oxygen by only 1/3 and a cell O turns cancerous, forever! harm in using fish HEART LUNGS oils? Professor Peskin maintains that the super-high doses they provide are extreme when compared to those manufactured within the body. Essential fatty acids provided via PEOs work like magnets, drawing oxygen into Furthermore, even the omega 3 cells and tissues. Reduce oxygen content to omega 6 balance they provide in cells by one third and they can become could be wrong and that the cancerous. body may actually require more cold-pressed seed oils, these omega 6 than is currently being include high linoleic safflower advocated today. Did you know oil, sunflower oil, evening that when a bear eats a fish he primrose oil and flax oil, all in throws away the body? Could it the proportions derived from be that the bear wants the omega Professor Peskin’s research- to 6 provided by the fish brain and supply the body with the ‘raw not the omega 3 that is within materials’ to produce essential its body? (The fish uses omega 3 fatty acids. as an anti-freeze due to its cold Maintenance doses are 1 or 2 water environment). capsules daily; for those with PEO-Pro™ greater need, 1 capsule per 40 lbs IAS is an organisation that has (18 Kg) bodyweight per day may always been committed to being be more suitable. ‘on the cutting-edge.’ It may Figure: This diagram highlights the benefits remain controversial, however of EFAs (essential fatty acids) that PEOs we have taken the decision to can deliver. remove fish and Beauty Heart Health Appetite krill based oils • Healthier Skin • Flexible Arteries • Less Cravings • Less Dandruff • Clean Arteries • Less Hunger from our range • Less Cellulite • Fast Blood Flow • Better Appetite • Healthier Hair • Lower Blood Pressure Fulfilment and replace • Eczema Improved • Improves Lipids them with PEOs that are Diabetes contained in Anti-inflammation • Less Sweet Cravings • Less Arthritis • Lower Blood Sugar PEO-Pro™. • Less Joint Pain/Swelling • Less Neuropathy/ SUPPORT • Faster Healing Retinopathy The PEO-Pro™ supplement contains Hormones/ Endurance Brain Health Endocrine • More Energy • Better Clarity organically • Better Sexual Function • Less Fatigue • Better Focus • Smoother Pregnancies • Greater Intensity • Improved Memory produced, • Less PMS • Order hotline: 1-866-800-4677 • e-mail:



Oxygen Magnets


• Fewer Headaches

• Helps Improve ADD & ADHD

• Faster Recuperation

SPOTLIGHT: CENTROPHENOXINE S MART DRUGS AND N UTRIENTS Centrophenoxine improves ‘recall speed’ Centrophenoxine, (pronounced, cent-rowfen-ox-in) is a classic ‘smart drug’ and features prominently in Dr. Ward Dean’s series of books on the subject. The term ‘smart drugs’ has become synonymous with substances that aid memory and cognition, although the correct medical terminology is ‘nootropics’ (which when translated from the Greek is‘towards the mind’).

for all senile dementia medications, since trying to revert the damage of a mid-late stage dementia is very difficult. The target therefore is at the earliest stage of dementia, or even before then, at the antiaging stage, wherein smartdrugs like centrophenoxine can improve/ enhance and protect the performance of an aging, but otherwise recognised as a healthy, individual.

Lipofuscin Professor Imre Zs.-Nagy says; “Centrophenoxine has shown many facets to improve conditions related to my membrane hypothesis of aging. For example, its ability to improve brain performance, survival time in animal experiments and to remove the cell-aging pigment called lipofuscin. It has been my antiaging supplement for more than 30-years.”

Background As shown in the insert, centrophenoxine is an ester of PCPA (a plant compound) and DMAE which is a natural cholinebased substance found in the diet, particularly in some kinds of fishwhich may be the reason why some believe that eating fish is “good for the brain.” Centrophenoxine has been studied extensively over many decades, principally in Europe and one of its leading proponents is the Gerontology expert, Professor Imre Zs.-Nagy, whom utilises it for his own antiaging purposes, keeping his mind sharp. One of the actions of centrophenoxine is to improve acetylcholine levels in the brain and it is this neurotransmitter that declines in Alzheimer’s diseaseleading to its devastating effects. Yet, centrophenoxine doesn’t make significant improvements for Alzheimer patients in this way, (note, there is another important action mentioned later on), although the same could be said

Lipofuscin is a waste material that accumulates in aging cells, especially those in the brain, heart, lungs and skin; indeed, in skin cells, lipofuscin can form part of the pigmented spots that are often referred to as ‘age’ or ‘liver’ spots. Lipofuscin accumulation can be very troublesome for the cell because it inhibits proper functioning from taking place, reducing the transference of chemicals through the cell wall, thus damaging both messaging and detoxification abilities. Indeed this inhibition and the inherent loss of lipidity that accompanies it, forms a significant part of Professor Zs.-Nagy’s ‘membrane hypothesis of aging.’ What we do know, is that when significant amounts of lipofuscin are present in the brain, they are then referred to as ‘plagues’ and then become recognised trait of Alzheimer’s. Perhaps it is therefore centrophenoxine’s primary mode of action to help remove lipofuscin deposits. It does it so well, that it is currently believed to be the best tool commercially available to do so and so well, that in patients with visible ‘age’ or ‘liver’ spots in the skin; it is possible over several weeks of centrophenoxine supplementation to see them fade or even disappear. Such patients can also benefit from the knowledge, that at the same, lipofuscin deposits are being reduced in their heart, lungs and brain etc.

General cognitive benefits Classifying the precise benefits of the various smart-drugs can be tricky. Most individuals often simply refer to their ailing cognitive facilities as “memory loss.” However, a quick breakdown of that statement requires further evaluation in order to determine the precise nature of the problem: • When you say “memory loss,” which of the following is it mainly related to? o Short term memory, (minutes or hours passing), example; “where are my car keys again?” o Medium term memory, (days or weeks), example; “what’s the name of our favorite Sunday lunch restaurant?” o Long term memory (months or years), example; “where did we holiday last year?” • Do you get bored easily and does your mind wander aimlessly? • Do you lack focus and attention? • Does your mind ‘fade’ quickly with any workload and you quickly become tired? • Is it actually remembering already learned experiences/ memories, (which is memory per-se), or is the problem in remembering not-yet learned experiences to recall well later on? (Referred to as memoryimprinting). • Is the problem not in the detail of recalling the memory, but in the time it takes to recall it? So over the years, we’ve come to classify the different smart-drugs and nutrients that we have, to establish which of the above the supplement in question is best suited to. Thus, in the case of centrophenoxine it is the last one. If your speech appears to be





full of “ums” and “ers” - whilst your brain tries to catch up with your mouth, then it is likely that centrophenoxine will be an aid for you. In our experience, centrophenoxine should not only be considered for those concerned with the development of Alzheimer’s, but when utilized correctly it can help many people, especially those aged over 40, to hasten their recall speed, bringing clarity and order to both speech and thought.


It is of course impossible to list all details of centrophenoxine use onto one page, but interested parties should ask for further details and read the articles with references that are available on the IAS website. A typical dose for the ‘average’ person is 250 mg once or twice daily; higher doses are necessary according to the varying degrees of Alzheimer’s. Note: Centrophenoxine is synergistic with other smart-drugs, in particular choline based forms such as piracetam (Nootropil®); these additional benefits can be experienced by using them concurrently, although naturally both doses need to be adjusted downward to suit.

Centro-Pro™, the leading brand of centrophenoxine used by its expert, Professor Imre Zs.-Nagy and his patients.

Showing the typical size and placement of lipofuscin in tissues.







The molecular structure of centrophenoxine, showing its combination of PCPA and DMAE. • Order hotline: 1-866-800-4677 • e-mail:



50mcg 8.7mg


90 58

3mg Amount Per Serving

* % Daily Value

Servings per container: 60 Serving Size: 1 tablet

Supplement facts:

Description: MZS is Dr. Walter Pierpaoli’s original melatonin formula containing the additional and supportive agents zinc and selenium. MZS is produced to pharmaceutical standards in Italy and unlike other melatonin preparations MZS has been designed to produce a night peak of melatonin between 1AM and 3AM to mimic the natural behavior of the pineal gland. Dr. Pierpaoli’s extensive animal and human research has shown that this is important because this action helps to stabilize circadian rhythms, improve hormonal cyclicity and boost immunity.


Dr. Pierpaoli’s original formula+

Formulated and distributed by Profound Products, PO Box 19, Sark GY9 0SB, Great Britain

MZS Dr. Pierpaoli’s original formula ™

Dr. Pierpaoli

MZS Dr. Pierpaoli’s original formula



Dr. Pierpaoli MZS Dr. Pierpaoli’s original formula

Directions: Take 1 tablet before bedtime, ideally between 10PM and 11PM.

% Daily Value * not established Other ingredients: Avicel, mannitol, povidonum and magnesium sterate Selenium Zinc

Dr. Pierpaoli MZS Dr. Pierpaoli’s original formula

Disclaimer: This product and its statements have not been evaluated by the FDA. This product is not intended to treat, cure or prevent any disease.


Note: Keep in cool dark conditions, out of the reach of children and consume before end of expiry date. Not for use by pregnant or lactating women.


Our melatonin has been formulated by the world’s foremost melatonin expert Dr. Walter Pierpaoli, his Melatonin Zn Se, or MZS™, is totally unique since it is designed to mimic the natural night peak of melatonin- to leave you feeling refreshed and alert the following day.

What does Melatonin do? Melatonin is vital to protect our hormonal system, regulate immunity and repair our body’s cells. It is commonly used by shift workers and also to treat jet lag and age related sleep disorders, but its abilities go far beyond simply its sleep inducing properties.

The antioxidant effects of melatonin Melatonin is an extremely effective antioxidant; in fact on a molecule to molecule basis; melatonin has proved to be significantly more efficient in neutralizing toxic

hydroxyl-radicals than the two well-known free radical scavengers, glutathione and mannitol.

many showed reversal of their ARMD. Remarkably this was true for both the wet and dry forms!

Melatonin’s effects on longevity

Why is Dr. Pierpaoli’s MZS™ more effective than other melatonin supplements?

Melatonin’s effect on longevity is well documented; in fact laboratory tests on rats and mice have demonstrated that melatonin increased their lifespans by 20%. Experts believe melatonin is a vital antiaging product because of its positive effect on aging. MZS™ and age-related macular degeneration Age related macular degeneration (ARMD) comes in two forms, wet and dry and is a notoriously difficult disorder to treat and is linked to blindness. A 24-month study, (published in NY Academy of Science, 2005, 1057:384-392) on 100 patients showed that after 3 months, the majority of patients taking 3 mg of Melatonin Zn Se nightly had halted the progression of their age related macular degeneration and at 6 months

There are three principal reasons, firstly it is of pharmaceutical quality at a dose of 3 mg, secondly it contains the synergistic ingredients of selenium and zinc, but thirdly and most importantly- it is designed to release at a very specific time. Dr. Pierpaoli’s research led him to perfect a formula that exactly mimics the pineal gland’s release of melatonin. Thus means that MZS™ is the only melatonin supplement to follow nature’s own night peak.


60 tablets Dietary Supplement

Melatonin is produced by the pineal gland at night to regulate our circadian rhythm, (sometimes called the sleep wake cycle). As we age the amount of melatonin we produce reduces resulting in many older people sleeping less and having a lower quality of sleep.

Dr. Pierpaoli


MZS Dr. Pierpaoli’s original formula ™

Dr. Pierpaoli


MZS™ is so much more than a sleep aid

Melatonin has had so many published benefits it is impossible to list them all here. From jet lag and shift work to well-being and antiaging, no other melatonin supplement offers the endorsement of Dr. Pierpaoli, or the exact formula used in all of his renowned clinical trials. If you’ve tried other melatonin and didn’t notice any significant effect, then we highly recommend you try Dr Pierpaoli’s MZS™ for a superior experience. Dr. Pierpaoli’s free ebook ‘The key of Life’ can be read here:

How much should I take?

Take half to one 3 mg tablet at bedtime only; do not take more than two tablets. By taking MZS™ between 9pm and 11pm you will create a night peak between 1am and 3am, this is the most natural and normal time to have the highest melatonin levels.

Left: Melatonin age decline graph

This graph compares Dr Pierpaoli’s melatonin formula (red line) to the natural release of melatonin (dark blue). Two other common types of melatonin supplements (light blue and green lines) demonstrate that sublingual melatonin peaks too soon and that time released formulas peak too late.

30 • Order hotline: 1-866-800-4677 • e-mail:

Above: Here are some before and after Fundus photos showing the benefit of Melatonin Zn Se. (Top before, below: after treatment).



ENHANCING AND IMPROVING STEM - CELL AC TIVIT Y Stem Cell Worx® is an intraoral spray that contains a very high-grade bovine colostrum, (with over 30% of the antibody IgG and over 54% protein) along with a 98% pure trans-resveratrol and 95% fucoidan (a seaweed extract). stem cells that come from an embryo. The Stem Cell Worx® supplement is designed specifically to enhance one’s own adult stem cells naturally. Stem Cell Worx® is an intraoral spray providing an absorption rate of up to 95% of its nutrients. This is important because in order for adult stem cells to be stimulated, it is the blood that is the principal carrier of nutrients and oxygen to our cells. In order to enhance cell activation you need three key factors, which are: • Growth factors • Immune factors and • Cytokines Stem Cell Worx® has all three of these factors in abundance and it is scientifically proven they are most effective when administered by intraoral spray delivery. Time takes its toll on adult stem cells. At 65 years of age, the release rate of adult stem cells entering the bloodstream has dropped by 80% compared to youth. It is important to keep them activated. The good news is it is now possible to reverse


Mesenchymal Stem Cells

Mesenchymal stem cells shown as a proportion of total cells in bone marrow. Lots of MSCs in our younger years. MSCs repair muscle, bone cartilage and tendons. MSCs rapidly decline with age. Longer repair and recovery times. More prone to aging and disease.

1/100,000 1/250,000



Age 30


Age 50

1/2,000,000 Age 80


% of Bone Marrow Cells Proliferated

It is a natural health supplement designed to activate the body’s own adult stem-cells in order to provide a robust immunity. With 50 to 70 trillion cells in the body, cellular health is clearly crucial to overall well-being and good health. Hence, adult stem cells working at optimal levels provide the platform for many cumulative health benefits. Unfortunately, as we age, our own adult stem cells decline rapidly, along with their release rates from the bone marrow, and our immune system weakens. Whilst stem cell clinics are at the forefront of antiaging medicine today, the process of full adult stem cell therapy is very expensive and due to regulatory restrictions results in long distance travel for many. Adult stem cells are the master cells of the body that have the ability to maintain, selfrenew and repair cells, tissue and muscle throughout an entire life-time. These cells are referred to as autologous, haematopoietic (blood), mesenchymal or stromal stem cells. Adult stem cells must not be confused with embryonic

80 70 60 50 40 30 20 10 0





Stem Cell Worx Concentration (mg/ml)

This study used blood samples from healthy humans. The adult stem cell proliferation percentages were determined by flow cytometry, measured in mgs of the Stem Cell Worx formulation. As this graph demonstrates the Stem Cell Worx formulation produces steady percentages of bone marrow stem cell proliferation being dose dependant, but still active at a relatively low dosage of mgs.

this statistic. Adult stem cells are the master cells of the body that have the ability to maintain, selfrenew and repair cells, tissue and muscle throughout an entire life-time. These cells are referred to as autologous, haematopoietic (blood), mesenchymal or stromal stem cells.

Stem Cell Worx® benefits

Stem Cell Worx® contains the greatest number of natural growth and immune factors compared to any other health supplement currently on the market. This enables natural stem cell activation to be as much as 75% per 36mg of formulation at any one time. This provides: • Support to naturally increase adult stem cells, providing the platform for many cumulative health benefits including: • Increased energy and endurance.

• Boosting the immune system. • Improved alertness and mental clarity. • Faster recovery after your exercise regime and faster repair and recovery after surgery, injury or illness. • Helping to build muscle, burn fat and maintain natural weight loss in conjunction with a healthy diet and exercise regime. IAS choose Stem Cell Worx® over other purported stemcell activators on the basis of evidence. The following graph demonstrates the benefits of supplementing daily with Stem Cell Worx.


6 sprays into the mouth provide 36mgs of formulation. This can be performed once or twice daily as required. Spray under the tongue, hold for 10 seconds, then swallow the remainder. Best taken on an empty stomach, at least 30-minutes before or after eating any food.

This figure shows the decline in stem cells with advancing age. • Order hotline: 1-866-800-4677 • e-mail:




THE PEP TIDE B IOR EG U L ATOR S FOR S KIN Those who are already familiar with the work of Professor Vladimir Khavinson from the St. Petersburg Biogerontology Institute in Russia, will know how remarkable his work has been in the discovery of short-chain peptide bioregulators- that act as highly specific gene switches. Now, four of these peptide bioregulators have been combined into topical skin preparations so that their performance can be bought to the field of aesthetic medicine; specifically the peptides in use are those from: • Cartilage • Blood vessels • Thymus gland • Pineal gland

What does each peptide provide for? The beauty product line Youth Gems® contains the listed peptides and a ginseng extract called Neovitin®. They represent the very latest developed program of complex skin care designed for the face, neck, hands and the body. The line includes four unique active ingredients of short-chain peptides that have a directed tissue-specific action to improve all basic skin structures: • The thymus gland peptide stimulates tissue regeneration and the synthesis of tissuespecific proteins. Thus, cells proliferative and metabolic activity is enhancedaccelerating the renewal of various cell tissues. It also has an anti-inflammatory action, improving the healing time of wounds, as well as antioxidant, immune stimulating and antistress actions. • The pineal gland peptide regulates metabolic processes and increases protein synthesis in skin cells. It also possesses potent antioxidant activity, normalizes the lipid peroxidation processes in skin cells that in turn promotes the elimination of negative


influences on the skin from external factors. • The cartilaginous tissue peptide stimulates regeneration of fibroblasts and keratinocytes and interferes with the destructive changes in collagen skin structure; it also strengthens collagen structure of elastic skin fibers and increases elasticity. • The vessel peptide regulates metabolic processes in the vascular wall, normalizes vascular tone and restores disturbed skin microcirculation. It strengthens and regulates the permeability of the vascular walls of skin vessels and improves skin turgor.

What else is included in Youth Gems® in addition to the four peptides? In addition to the four peptides, the Youth Gems® also contain an incredible array of beneficial natural agents- which just by themselves would make other antiaging creams jealous! The range includes: Neovitin® (a complex isolated from ginseng), olive oil, raisin-seed oil, Argon oil, Soya oil, Jojoba oil, Bisabolol (extract from chamomile), Peony extract,

sodium hyaluronate (a derivative of hyaluronic acid), green tea extract, cocoa oil, carrageenan (from seaweed), winter bloom, almond extract and vitamin E.

What results have been seen? Clinical trials and examinations have been conducted at the St. Petersburg Biogerontology Institute and they have concluded that these short chain peptides, when applied to skin cells, have many beneficial activities, shown below are some of those results. These include improved metabolism in vascular wall cells, the growth of new skin cells, enhanced antioxidant activity; increased blood flow circulation and greater moisturization. The skin’s appearance becomes smoother, with fewer wrinkles and with more elasticity, all of which helps to lift the face contours producing a more radiant, youthful appearance. These beneficial effects were noted in 100% of women who took part in the voluntary clinical trial.

What’s available? • Body milk: The body milk is a very light cream that can be applied to most areas of the body. • Day cream: The day cream is the core product designed to be applied to the face and hands. • Serum: The serum is designed to be used sparingly against the most noticeable skin aging effects on the face and neck. • Tonic: This cleanser can be used to help any area become more firm and taught and may be splashed on as required. All of the Youth Gems® should be applied onto clean, dry skinavoiding the eyes; makeup can be applied after absorption - if required.

Right: A 68 year old female before (left) and after (right) application of Youth Gems® • Order hotline: 1-866-800-4677 • e-mail:

SPOTLIGHT: PEPTIDE BIOREGULATORS THE DI SCOVERY OF G ENE SWITCHES IN FOOD Today Professor Vladimir Khavinson is the President of the European Academy of Gerontology and Geriatrics, but in the 1980’s he was a Colonel in the Soviet Union military medical corps. At the time, he and his team were approached by Kremlin officials, they wanted them to find a way to protect their troops from a myriad of problems; issues such as radiation for submariners in nuclear submarines to troops that may be blinded from known, (but thankfully unused) new weapons such as battlefield lasers.

A former Soviet military secret! What their research uncovered - that was used for two decades on many thousands of men and women - was a remarkable link between short chain peptides and DNA. This former military secret is now available to the public as peptide bioregulators. Their published research has identified that each organ / gland / tissue uses a highly specific short chain peptide, obtained from food, to act as a ‘short-cut’ to initiate protein synthesis. These peptides, unlike proteins, can enter the blood through the stomach. Through a comprehensive list of patents and even copyrighted PowerPoint slides, the Russian research group have shown that each of the concentrated

Above: A short-chain peptide bioregulator interacting with DNA

peptide bioregulators so far examined, interact with particular strands of DNA - effectively and very specifically activating repair and regenerative processes. This is a remarkable story since what we are describing here are peptides that act as individualised gene switches. To date, they have been tested for many years on thousands of individuals, without report of any serious side effects or contraindications. We believe that they could be set to ‘out do’ stem cells. Why? Because this peptide therapy is relatively cheap, highly specific, can be taken orally and doesn’t require any suppression of the immune system to operate fully (as stem cells do).

Original material from the trials The peptide bioregulators available via IAS are the bovine originals; sourced from carefully chosen Danish calves and processed through pharmaceutical processes and filters. They are not the synthetic versions which have not been studied/ proven. Peptide bioregulators act as they sound- to regulate; for example, Thyreogen®

the thyroid peptide would increase thyroid activity if it were too low, but decrease it if it were too high!

Dosing Doses are very dependent upon the need and unlike hormones these peptides do not have to be taken every day, hence making them a cost effective regime. A typical/ average use could be considered as follows:

• Start with an intensive course: 2 capsules once a day for 30-days. • Thereafter use 2 capsules once a day for 10-days, repeat every 2, 3, 4 or even as little as 6-months. The story of the peptide bioregulators is a remarkable one and we recommend that you to read the articles and interviews and see the video on the IAS website.

PEPTIDES CURRENTLY AVAIL ABLE: Cerluten® is the... Chelohart® is the... Chitomur® is the... Endoluten® is the... Glandokort® is the... Gotratix® is the... Libidon® is the... Pielotax® is the... Sigumir® is the... Suprefort® is the... Stamakort® is the... Svetinorm® is the... Taxorest® is the... Testoluten® is the... Thyreogen® is the... Ventfort® is the... Visoluten® is the... Vladonix® is the... Zhenoluten® is the...

brain peptide bioregulator. heart peptide bioregulator. bladder peptide bioregulator. pineal peptide bioregulator. adrenal peptide bioregulator. muscle peptide bioregulator. prostate gland peptide bioregulator. kidney peptide bioregulator. cartilage peptide bioregulator. pancreas peptide bioregulator. stomach mucus peptide bioregulator. liver peptide bioregulator. lung peptide bioregulator. testes peptide bioregulator thyroid peptide bioregulator. blood vessel peptide bioregulator. retina peptide bioregulator. thymus peptide bioregulator. ovary peptide bioregulator. • Order hotline: 1-866-800-4677 • e-mail:


SPOTLIGHT: BIOIDENTICAL HORMONES OX Y TOCIN FOR PA SS ION AND S E X IAS carries a wide range of bioidentical hormones - a term that means ‘natural to and in the body’. In this featured section we are focusing on oxytocin. What is oxytocin? Oxytocin is a hormone produced by the hypothalamus, but excreted via the pituitary gland. Its orthodox medicine role is to help women give birth, since the large dose that’s injected helps relaxes the uterus and alleviates the passage of the child into the world for the mother.

Above: Dr. Thierry Hertoghe

However, as we will discover and as been highlighted by Dr. Thierry Hertoghe’s book; ‘passion, sex and longevity, the oxytocin adventure’ -it has many other roles to play too.

The love hormone Oxytocin has been dubbed ‘the love hormone’, why would this be? Principally because oxytocin can induce feelings of bonding and care and not just between

individuals, but even with animals too! Oxytocin measurements have been taken between lovers, friends, relatives, parents and their children etc. From those results, it has been noted that oxytocin levels are higher when they are in their presence. Mothers naturally bond with their children, but even men, (especially those who experience the live birth), express their emotions as wanting to care and protect their offspring, these effects may be attributable to the release of oxytocin hence triggering the bond. On the other side of the coin, psychopaths are notoriously low in their oxytocin levels, which may be a cause of their uncaring feelings towards other humans.

The pain and orgasm connection Fibromyalgia can be a very debilitating disorder with a lot of pain, sometimes constant for those who suffer with it. In women it was noted that when they were experiencing an orgasm they felt no pain at all. Later, it transpired that women

undergo a burst of oxytocin during orgasm. Trials were undertaken to see if oxytocin supplementation could alleviate the pain of fibromyalgia, there was some success, but the side-effect noted was that those women now enjoyed multiple orgasms! This was a fact picked up on by the popular press and is probably singularly the action most responsible for bringing oxytocin into the public gaze.

Synergy Dr. Hertoghe has explained that some folks will not feel the effects of oxytocin. This is principally because of two reasons, (if we consider that the dose is correct for that individual). Firstly, that some people are ‘low’ in their own principal sex-hormone, so if a man is low testosterone, or if a woman is low estrogen, it is possible that oxytocin will not elicit its full potential in those persons. The other issue could be low vasopressin; vasopressin

Dosing As might be expected doses are very dependent upon its use. However for social or sexual enhancement, one can consider 5 IU to 10 IU a ‘typical’ dose. In fact, Dr. Hertoghe has somewhat reduced the doses that he recommends in his book, (transmitted via personal conversation to me). Currently IAS is providing Oxy-Sub™ in 20 IU trouches (a soft sublingual tablet), these can therefore be cut into half or quarter for a dose of 5 or 10 IU and should be placed under the tongue and allowed to melt. The other option is Oxy-Pro™ which is applied intranasally delivering 10 IU per spray.

Dr. Thierry Hertoghe’s book, “Passion, sex and longevity - the oxytocin adventure”, details its roles and uses in a ‘how to’ guide form.

“...oxytocin can induce feelings of bonding and care and not just between individuals, but even with animals too!” 34

is a counterpart to oxytocin, produced and released via the same glands. In cases of vasopressin deficiency, the patient may enhance the oxytocin experience by adding one or two sprays (10 IU each) of vasopressin via the Vaso-Pro™ nasal spray. • Order hotline: 1-866-800-4677 • e-mail:


EUROPE CONGRESS 2015 The event of the year in medical therapies that reduce, slow down or even reverse aging

November 19-22, 2015, Brussels

Contact: Email: • Tel: 00352 - 621 20 42 89 / 011 - 352 621 20 42 89 (USA & Canada) For more details:

A-Z PRODUCT LIST OTHER INFO KEY: Not shipped to UK Not shipped to EU


Not shipped to Japan Not shipped to Australia (or New Zealand)




Not shipped to Canada



1 complete kit




90x 100mg capsules




30x 100mg tablets




50 capsules




1 inhaler




40x 300mg capsules




5ml 10mg ear spray




15x 125 mcg capsules




90x 75mg tablets




30x 420mg capsules




28x 1mg tablets




28x 100mcg capsules




60 capsules




20x 750mg capsules




60x 20mg tablets




8x 1mg i.m. ampoules




20ml tube cream




30x 50mg tablets




120x 10mg capsules




one complete kit



BIO-CLIP ™ V2.00

one complete kit




60 capsules




60 capsules




30x 2.5mg tablets




8x 0.5mg tablets




2x 5ml vials




90 capsules




60x 250mg




5x 5ml i.m. ampoules




4x 20mg tablets


$79.99 • Order hotline: 1-866-800-4677 • e-mail:







10x 500mg tablets




40x 1mg tablets




30x 100mg capsules




30x 125mg capsules



D3 (VITAMIN D) D3-5000™

100x 5000 IU capsules




12x 50,000 IU capsules




50x 5mg tablets




20ml/ 300mg bottle




200ml bottle




2.5ml nasal spray




60 capsules




100 capsules




8x 100mg capsules




30x 0.5mg tablets




120x 10mg capsules




50ml 100mg cream




28x 5mg tablets




15x 5mg tablets




7x 50mg capsules




100x 20mcg tablets




Food allergy blood





test-kit for 95 foods


100x 300mg capsules




20x 500mg tablets




30x 8mg capsules




60x 250mg tablets




5x 5ml ampoules




25x 100mg tablets




60x 100mg tablets




120ml 120mg liquid




2 oz. spray




2 oz. spray bottle




30x 5ml liquid sachets




30x 4.5mg capsules



® • Order hotline: 1-866-800-4677 • e-mail:






100x 5mg capsules




60x 30mg tablets




30x pack




30x pack




50ml 1% cream




60x 250mg capsules




100x 5mg capsules




50x 500mg capsules




2 oz. liquid 400mg




60x 3mg tablets




2 oz. liquid 90mg





NOTE: The UK can order melatonin in Pounds Sterling at: MEMANTINE (NAMENDA® ; EBIXA®) MEMANTINE-PRO™

42x 10mg capsules




50x 500mg tablets




56x 500mg tablets




56x 50mg tablets




16 oz. liquid bottle




30ml bottle topical liquid




75g powder




30x 150mg tablets



MODAFINIL - Please see for availability and pricing MSH (MELANOCYTE STIMULATING HORMONE) NEW: MSH2-PRO™

5ml 500IU nasal spray




30x 4.5mg capsules




30 lozenges




50ml tube toothpaste




50x 10mg tablets




10 saliva strips




60ml bottle shampoo




30x 100mg capsules




30x 5 IU sublingual troches






(2% KETOCONAZOLE) • Order hotline: 1-866-800-4677 • e-mail:







5ml 500 IU nasal spray




30x 250mg sachets




120 capsules



20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules 20x 200mg capsules

$79 $79 $79 $79 $79 $79 $79 $79 $79 $79 $79 $79 $79 $95 $79 $79 $79 $79 $79

$69.99 $69.99 $69.99 $69.99 $69.99 $69.99 $69.99 $69.99 $69.99 $69.99 $69.99 $69.99 $69.99 $89.99 $69.99 $69.99 $69.99 $69.99 $69.99


30x 25mg capsules




60x 50mg tablets




20 grams 100ml liquid




60x 800mg tablets




100x 800mg tablets




2 oz. liquid 99mg bottle




30x 20mg capsules




Spirometer + 4 tubes




25 additional tubes




40x 300mg tablets




50x 100mg capsules




50ml 2.5 grams (5%) cream




30x 50mg tablets




60 capsules




60x 50mg tablets




60x 100mg tablets











30x 1mg capsules




60x 4mg tablets




5ml 500 IU nasal spray




30x 150mg capsules




30ml cream




30ml cream



RETIN-A® 0.100%

20ml micro-gel




10x 50mg tablets




20x 400mg




2 oz. liquid 300mcg




30ml 30mg liquid




2 oz. spray




60x 12.5mg tablets




3.5ml liquid spray




4x 500ml liquid bottles



TA65 ®

90 capsules




16x 250mg tablets




90x 200mg capsules




* Please note other than UK; this product has a shipping surcharge of $10 because of its weight.


100x 15mg tablets 100x 30mg tablets 100x 60mg tablets 100x 90mg tablets 100x 120mg tablets

$79 $89 $99 $149 $169

$69.99 $79.99 $89.99 $139.99 $159.99


100x 30mg tablets 100x 60mg tablets 100x 125mg tablets

$59 $79 $99

$49.99 $69.99 $89.99


100x 15mg tablets 100x 30mg tablets 100x 60mg tablets 100x 90mg tablets 100x 120mg tablets

$49 $55 $69 $79 $89

$39.99 $44.99 $59.99 $69.99 $79.99


100x 100mcg tablets




50x 20mcg tablets




20x 5mg sublingual tablets




28x 25mg tablets




40 • Order hotline: 1-866-800-4677 • e-mail:







5 ml 500 IU nasalspray




28x 37.5mg tablets




4x 100mg tablets




633 inter-nasal laser




120x 10mg capsules



8 oz. liquid bottle




50x 150mg tablets




100x 5mg tablets




200ml bottle




50ml pump




30ml dropper




200ml bottle




2 oz. spray




2 oz. liquid 50mg bottle











169 pages



159 pages



833 pages



327 pages





BY DR THIERRY HERTOGHE • Order hotline: 1-866-800-4677 • e-mail:


CONDITION CROSS-REFERENCE LIST This cross-reference list highlights individual products that have been used for these disorders. Note: It does not mean that all these products are synergistic together.

Addison’s disease Aldosterone, peptide bioregulator (Glandokort®) ADHD (ADD, attention deficit disorder, see mental stimulants) Adrenal fatigue Aldosterone, Digestif®, hydrocortisone, peptide bioregulator (Glandokort®) AGE (advanced glycated end-product inhibitors) ACF228™, aminoguanidine, Can-C™ Plus, carnosine, metformin, pyridoxamine Age Related Macular Degeneration (see eyesight) Age Related Mental Decline (see cognitive) AIDS (see HIV)

Arterial (See heart, arterial & blood) Arthritis (rheumatoid & osteo) Andro-Pro™, Gerovital-H3®, Novisyn®, PEO pregnenolone, pyritinol, SAMe, thymus Asthma (see Allergies) Autism (also see chelation agents) Oxytocin, piracetam Back problems (see spine) Bells’ palsy Vitamin B12 Blood disorders (see heart, arterial & blood) Blood pressure Neo40®, magnesium, oxytocin, potassium, propranolol, vinpocetine

Alcoholism (also see compulsive disorders) 5HTP, L-tryptophan, memantine

Bone problems (also see joints & arthritis) Andro-Pro™, Bone-Pro2™, Esnatri™, Peptide Bioregulator (Bonomarlot®), progesterone, SAMe, thyroid

Allergies pregnenolone, thymus

Breathing (see lungs)

ALS (amyotrophic lateral sclerosis, see Lou Gehrig’s disease)

Anabolic (see growth hormone & testosterone)

Cancer (also see anti-oxidants & radiation) 1st Line™, anastrozole, artemisinin, BEC5® Curaderm, bromocriptine, CurcuminSR™, D3, DIM-Pro2™, laetrile, melatonin, metformin, naltrexone, oxaloacetate, progesterone, Resveratrol-Pro™, thymus, TRH

Anginas (see heart, arterial & blood)

Cardiovascular (see heart & arterial disorders)

Animal use Can-C™ eye-drops, deprenyl, L-tryptophan, peptide bioregulators

Cataplexy (sudden fatigue) Adrafinil, modafinil, picamilone

Antiaging (as impacting on a particular theory of aging) Calorie Restriction Carnosine, metformin, resveratrol Free radical ACF228™ Glycation Aminoguanidine Hayflick Carnosine, TA65® Membrane Centrophenoxine Mitochondrial Hydergine®, PQQ Neuroendocrine Metformin, TRH Rotational Melatonin Telomeres Endoluten®, TA65®

Cataract (also see eyesight) Can-C™, Can-C Plus™

Alzheimer’s disease (see senile dementia)

Anti-biotics Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline Anti-depressants Lithium, milnacipran, moclobemide, reboxetine, Stablon®, Valdoxan®, venlafaxine Anti-oxidants (see free radical scavengers) Anxiety (see stress)

Central Nervous System (CNS) Peptide bioregulator (Cerluten®) Cholesterol (see blood disorders) Crohn’s disease Naltrexone Chronic fatigue syndrome (see mental stimulants & physical energy improvement) Cognitive (also see memory & senile dementias) Alertness Adrafinil, modafinil Creativity Aniracetam, piracetam, pramiracetam Focus/concentration Deprenyl, desmopressin, vasopressin Energy ATP-Boost™, centrophenoxine, picamilone General support Gerovital-H3®, vinpocetine Intelligence Hydergine® Work load Hydergine®, thyroid

ARMD (see eyesight)

42 • Order hotline: 1-866-800-4677 • e-mail:

Compulsive disorder treatment (also see alcoholism) 5HTP, Gamalate®, L-tryptophan, picamilone

Fertility Melatonin, metformin, peptide bioregulator (Zhenoluten®), TRH

Cortisol alteration (also see stress) Aldosterone, DHEA, fludrocortisone, GABOB, Gamalate®, Gerovital-H3®, hydrocortisone, peptide bioregulator (Glandokort®), phenytoin

Fibromyalgia (also see physical energy & mental stimulants & pain relief) 1st Line, milnacipran, naltrexone, oxytocin

Cross linking (see AGE)

Free radical scavengers ACF228™, ATP-Boost™, glutathione, idebenone, melatonin, Mito-Pro2™, pyritinol

Deep vein thrombosis (see frequent fliers)

Gastrointestinal (see digestive)

Dental (see teeth & gums)

Glaucoma (see eyesight)

Depression (also see well-being & anti-depressants) 5HTP, aniracetam, ATP-Boost™, CurcuminSR™, D3, deprenyl, Gerovital-H3®, lithium, L-tryptophan, milnacipran, picamilone, piracetam, pramiracetam, pregnenolone, SAMe, thymus, thyroid

Glucose control (see diabetes)

DHT alternation (dihydrotestosterone) Dutasteride, finasteride, Hair-Pro™, MinSaw™, Nanogens®, peptide bioregulator (Libidon®), progesterone Diabetes Acarbose, aminoguanidine, ATP-Boost™, benfotiamine, L-carnosine, metformin, PEO, peptide bioregulator-(Suprefort®), pyridoxamine, TRH, thyroid

Glycation prevention (see AGE) Gout Colchicine Growth hormone (improvement) Beyond GHS®, bromocriptine, deprenyl, GABOB, Gamalate®, GHRP2, GHRP6, hydergine, Neo40®, sermorelin, thymus, thyroid Hair improvement Dercos®, dutasteride, finasteride, Gerovital-H3®, Hair-Pro™, MinSaw™, Nizoral®, PEO Headaches (see migraines)

Diabetes insipidus (see urination)

Heath diagnostics (see at home test kits)

Dieting (see weight loss)

Hearing disorders Aldosterone, Anacervix®, fludrocortisone, nicergoline, picamilone, vinpocetine

Digestive issues Digestif®, peptide bioregulator (Stamakort®), Symprove® DNA support (also see telomeres) Carnosine, CoQ10, D3, PEO, peptide bioregulators, PQQ, resveratrol, TA65® Down’s syndrome Melatonin, piracetam Energy improvement (see physical energy & mental stimulants) Enzymes Boluoke® Epilepsy GABOB, Gamalate®, phenytoin Erectile dysfunction (also see sex-libido & premature ejaculation) Andro-Pro™, cabergoline, Cialis®, Neo40®, oxytocin, Viagra®, Vigor-Pro2™, yohimbine Eyesight ARMD MZS™ Cataracts Can-C™, Can-C™ Plus Contact lenses Can-C™ Dry eyes Can-C™ General support Aminoguanidine, peptide bioregulator (Visoluten®), vinpocetine Glaucoma Can-C™ Retinal MZS™, nicergoline, picamilone Retinal pigmentosa Picamilone, peptide bioregulator (Visoluten®) Excitotoxins (reduction) Carnosine, deprenyl, idebenone, lithium, memantine

Heart, arterial & blood (includes blood markers) Arteries (hard) Aminoguanidine, Bio-CLIP™, BioCUFF™, carnosine, resveratrol Blood pressure (high) Magnesium, Neo40®, potassium, Propranolol, vinpocetine Calcium Peptide bioregulator (Bobothyrk®) Cholesterol (high) CoQ10, Gerovital-H3®, TRH, XanPro™ Dilation (nitric-oxide) Neo40®, Vielight® Fibrinogen CurcuminSR™, TRH General support CoQ10, PEO, peptide bioregulators (Chelohart® & Ventfort®), PQQ, vinpocetine Glucose (high) Acarbose, metformin, TRH Glycated end-products Aminoguanidine, metformin Heart pulse (irregular) ATP-Boost™, thyroid Heavy metals (chelate) BCI®, Homocysteine: BCI®, TRH Lipofuscin Centrophenoxine Plaques (clots) Boluoke® Triglycerides CurcuminSR™, PEO, TRH Hepatitis (see liver and infections) Herpes (also see anti-biotics) 1st Line™, ACF228™, BHT, silver protein HIV (also see immune system improvement) 1st Line™, melatonin, naltrexone, thymus HGH (see growth hormone) Homocysteine (see blood disorders) • Order hotline: 1-866-800-4677 • e-mail:


HRT (hormone replacement therapy for women) Esnatri™, melatonin, progesterone Human growth hormone (see growth hormone) Hypertension (see blood pressure) Hypothyroidism Iodine, peptide bioregulator- thyroid (Thyreogen®), thyroids IBS (irritable bowel syndrome) Symprove® Immune system improvement (also see infections) 1st Line™, ATP-Boost™, carnosine, melatonin, peptide bioregulator- thymus (Vladonix®), peptide bioregulator- thyroid (Thyreogen®), pyritinol, resveratrol, thymus, thyroid Infections (also see immune system improvement, anti-biotics & influenzas) 1st Line™, artemisinin, fluconazole, silver protein Inflammation (reduction) BCI®, Boluoke®, CurcuminSR™, Digestif®, PEO, pregnenolone, thymus Influenzas (also see anti-biotics, infections & immune system improvement) 1st Line™, D3 Insulin & glucose control (see diabetes) Intestinal flora (see probiotics)

Memory (also see cognitive & senile dementia) General support PEO, picamilone, vinpocetine Imprinting (for later recall) Desmopressin, vasopressin Medium-long term Hydergine® Short term Aniracetam, piracetam, pramiracetam Speed of recall Centrophenoxine, pyritinol Methylation (conversion of one chemical into another inside the body) ATP-Boost™, Boluoke®, SAMe, Xan-Pro™ Migraines (also see pain relief) nicergoline, memantine, picamilone, vitamin B12 Mitochondrial support ATP-Boost™, CoQ10, deprenyl, glutathione, Hydergine®, idebenone, Mito-Pro2™, NADH, oxaloacetate, PQQ, pregnenolone, SAMe Mtor inhibitors Oxaloacetate Multiple Sclerosis (also see mitochondrial support) Melatonin, naltrexone, TRH Muscles (see sarcopenia) Nail condition Gerovital-H3®, PEO

Joints (also see bones & arthritis) Boluoke®, PEO, peptide bioregulator (Sigumir®), Novisyn®, pregnenolone, SAMe, thymus

Narcolepsy (sleeping in the daytime) Adrafinil, melatonin, modafinil, picamilone

Kidney disorders (also see infections) Aminoguanidine, peptide bioregulator (Pielotak®) SAMe, TRH

Nitric Oxide release Neo40®, Nitric Oxide saliva test strips, Vielight® laser

Learning (also see memory & mental stimulants) Aniracetam, desmopressin, Hydergine®, piracetam, pramiracetam, vasopressin

Oral health care (see teeth & gums) Osteoporosis (see bone problems)

Libido (see sex)

Pain relief ATP-Boost™, Gerovital-H3®, memantine, milnacipran, nicergoline, oxytocin

Lipids (see blood disorders)

Parasites (see infections)

Liver disorders (also see infections) CoQ10, Idebenone, peptide bioregulator (Svetinorm®), pregnenolone, SAMe, silver protein

Parkinson’s disease (see senile dementia)

Longevity enhancement (significant lifespan increases seen in animal studies) Centrophenoxine, deprenyl, melatonin, vasopressin

Photoaging (see skin problems)

Lou Gehrig’s disease (ALS) Naltrexone, TRH Lungs ACF228™ Breathe-Easy, centrophenoxine, glutathione, peptide bioregulator (Taxorest®) Lupus Milnacipran, naltrexone Lyme’s 1st Line™, silver protein Macular degeneration (see ARMD & eyesight) Malaria (also see antibiotics) Artemisinin Menopause (see HRT)


Mental stimulants (also see physical stimulants) Adrafinil, aniracetam, centrophenoxine, deprenyl, desmopressin, modafinil, nicergoline, picamilone, piracetam, pramiracetam, vasopressin, Xan-Pro™

Pets (see animal use)

Physical energy improvement (also see mental stimulants) ATP-Boost™, carnosine, CoQ10, idebenone, Mito-Pro2™, NADH, oxaloacetate, PQQ, pregnenolone, SAMe, yohimbine PMS (pre-menstrual syndrome) PEO, peptide bioregulator (Zhenoluten®), vinpocetine Premature ejaculation/ ejaculate (also see erectile dysfunction & sex-libido) Oxytocin Prostate (also see cancer) D3, DIM-Pro2™, dutasteride, finasteride, melatonin, peptide bioregulators – (Chitomur® & Libidon®), Prostate-Pro2™ Prolactin alteration Bromocriptine, cabergoline, GABOB, Gamalate® • Order hotline: 1-866-800-4677 • e-mail:

PSA (prostate specific antigen) (see prostate)

Stomach (see digestive)

Urination (frequent) Peptide bioregulator (Chitomur®), vasopressin

Sunburn (see skin problems)

RNA (see DNA support) Sarcopenia (muscle atrophy/wastage) GHRP2, GHRP6, peptide bioregulator (Gotratix®), sermorelin Senile dementia (also see cognitive & memory) Alzheimer’s Centrophenoxine, CurcuminSR™, galantamine, Hydergine®, memantine, nicergoline General support Anacervix®, aniracetam, PEO, piracetam, pramiracetam, vinpocetine Parkinson’s Bromocriptine, cabergoline, NADH, deprenyl, rasagiline Senility Gerovital-H3® Sex (libido, also see erectile dysfunction & premature ejaculation) Andro-Pro™, deprenyl, MSH, oxytocin, yohimbine Skin problems (also see tanning) Acne: BG-Pro™ cream Age (liver) spots Centrophenoxine Anti-glycation Aminoguanidine, carnosine, Youth Gems® serum Anti-oxidant Youth Gems® day cream Cancer (non-melanoma) BEC5® Curaderm Cellulite Youth Gems® body milk Collagen Novisyn® Environmental Youth Gems® serum General support Gerovital-H3®, melatonin, PEO, thyroid Hyaluronic acid Novisyn® Infections Silver protein, thymus Moisturizer Youth Gems® day cream Sun spots BEC5® Curaderm Wounds HemaGel® Wrinkles Retin-A®

Syndrome X (metabolic syndrome) Aminoguanidine, ATP-Boost™, melatonin, metformin, PEO Tanning (darkening the coloration of skin) MSH Teeth & gum disorders Doxycycline, mineral mouthwash, NeyDent® toothpaste, silver protein, zeolite Telomeres (also see DNA support) Carnosine, PEO, peptide bioregulator- pineal (Endoluten®), TA65® Testosterone & testes (also see fertility and prostate) Andro-Pro™, anastrozole, Beyond GHS®, DIM-Pro2™, melatonin, oxytocin, peptide bioregulator (Testoluten®), TRH, zinc Triglycerides (see blood disorders) Veterinarian (see animal use) Weight gain (muscle mass) Andro-Pro™, Beyond GHS®, GABOB, GHRP6, sermorelin Weight loss (appetite suppressants and diet aids) 5HTP, acarbose, aminoguanidine, ATP-Boost™, benfotiamine, DIM-Pro2™, galantamine, GHRP2, L-tryptophan, metformin, Mito-Pro2™, MSH2, thyroid, TRH, Xan-Pro™ Well-being (also see depression) 5HTP, aniracetam, ATPBoost™, deprenyl, Gamalate®, Gerovital-H3®, L-tryptophan, melatonin, Mito-Pro2™, PEO, picamilone, piracetam, pramiracetam, SAMe, thymus, thyroid, zeolite

Sleep disorders For less sleep adrafinil, ATP-Boost™, modafinil For more sleep 5HTP, gabapentin, L-tryptophan, melatonin Smoking cessation 5HTP Spine issues Peptide bioregulator (Sigumir®), Novisyn® Sports (see growth hormone, estrogen alteration, physical energy & testosterone) Stress (also see cortisol) 5HTP, GABOB, Gamalate®, Gerovital-H3®, L-tryptophan, melatonin, oxytocin, picamilone, phenytoin, propranolol, pregnenolone Stroke Anacervix®, aniracetam, Boluoke®, Hydergine®, idebenone, nicergoline, picamilone, piracetam, PQQ, pramiracetam, pregnenolone, vinpocetine • Order hotline: 1-866-800-4677 • e-mail:


*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.

*Offers valid until August 31st 2015


Adrafinil is a unique stimulant that stimulates only when stimulation is required, which means it doesn’t affect normal sleep patterns.

Adra Pro (Adrafinil) 40 x 300mg Caps $49.99 AGING MATTERS SPECIAL: $5 off per pack NOW ONLY $44.99*

A-Z INGREDIENT LIST The following list is intended to highlight the key ingredients in some products and cross reference them to the most relevant product brand names. Note: Those products with the same name as the ingredients are not shown here as they are within the A-Z product list.

If you want this-

look for:



Blueberry extracts


Acetyl-L-Carnitine (ALC)

ATP-Boost™, Vigor-Pro2™


Andro-Pro™, Can-C™

Adenosine triphosphate (ATP)




AGE (advanced glycated end-product inhibitors)

ACF228™, aminoguanidine, Can-C™ Plus, carnosine, metformin, pyridoxamine



Buxamin (GABOB)

Gamalate®, Gamibetal®







Allicin (garlic)




Alpha lipoic acid (includes R-lipoic acid)

ATP-Boost™, Mito-Pro2™

Chelation agents

Carnosine, centrophenoxine, EDTA, zeolite





Amino acids (includes di-peptides)

5HTP, ACF228™, ATPBoost™, carnosine,

Chromium polynicotinate




Co-dergocrine mesilate


Coenzyme Q10

CoQ10, Mito-Pro2™

Cortisol (cortisone)

Fludrocortisone, hydrocortisone

Cranberry extracts




Cresote bush

ACF228®, Digestif®




CoQ10-SR™, Curcumin-SR™, resveratrol

L-tryptophan, Mito-Pro2™ Aminohydroxybutyric acid (GABOB)

Gamalate®, Gamibetal®






Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline


Lithium, milnacipran, moclobemide, reboxetine, Stablon®, Valdoxan®, venlafaxine


See free radical scavengers






DIM-Pro2™, EDTA, zeolite

Astragalus extracts





DHA (docosahexaenoic acid)

Benzoic acid




Beta blocker


Di-IndolylMethane (DIM)

ACF228™, DIM-Pro2™

Beta alistine

Carnosine, ACF228®, Can-C™, Can-C Plus™

DMAE (dimethylaminoeth- Centrophenoxine anol)

Beta glucan


DMSA (dimercaptosuccinic ACF228™, DMSA-Pro™ acid)



BHT (butylhydroxytoluene)

ACF228™, BHT-Pro™

DMSO (Dimethyl sulfoxide) Laetrile D-pantethine

Can-C Plus™ • Order hotline: 1-866-800-4677 • e-mail:


Dr. Dean’s recommended products

Acarbose, centrophenoxine, CurcuminSR™, Hydergine®, metformin, piracetam, Xan-Pro™

Natural (animal): Armour® thyroid, ERFA® thyroid, Nature® thyroid, thymus, vasopressin

Dr. Pierpaoli’s recommended products

Melatonin, TRH

Dr. Wright’s recommended products

DHEA, Esnatri™, progesterone

Synthetic: Desmopressin, Eutirox® thyroid, fludrocortisone, hydrocortisone, T3-Pro™



EDTA (ethylene diamine tetraacetic acid)








EPA (eicosapentaenoic acid) Ergoloid mesylate

HRT (hormone replacement therapy for women)

DHEA, Esnatri™, melatonin, progesterone

Hyaluronic acid (hyaluronan)

Hair-Pro™, Novisyn®


IGF-1 (insulin like growth factor one)


Hydergine®, nicergoline

Indol-3-Carbinol (I3C)


Estrogens (estradiol, estriol, Esnatri™ estrone)

Injectable products

Cerebrolysin®, Cromatonbic® (B12), Gerovital®



Inter-ear products


Folic acid (folate)

ACF228™, DIM-Pro2™§

Inter-nasal products

Free radical scavengers

ACF228™, ATP-Boost™, BioEn’R-Gy C®, glutathione, idebenone, melatonin, Mito-Pro2™, pyritinol

Desmopressin, MSH, oxytocin, GHRP6 (Releasing-Pro™), vasopressin, Vielight® laser

Iodide/ Iodine

ACF228™, BCI, Iodine-Pro™







GABA (gamma-aminohydroxybutyric acid)

Gamalate®, picamilone




Gamalate®, Gamibetal®




Youth Gems®





Glycerine (glycerin)



BEC5 Curaderm®

Hawthorne Berry (crataegus)


HGH (human growth hormone/ somatropin)

GABOB, GHRP2, GHRP6, sermorelin

Hormones (includes Bio-identical: Aldosterone, hormonal support supple- Esnatri™, melatonin, MSH, ments) oxytocin, pregnenolone, progesterone, TRH


Supporting agents: DIMPro2™, GHRP2, GHRP6, peptide bioregulators, SAMe, sermorelin




Carnosine, ACF228®, Can-C™, Can-C Plus™




Can-C Plus™



Lipoic acid (includes R-lipoic acid)

ATP-Boost™, Mito-Pro2™


ACF228™, Can-C Plus™






Andro-Pro™, Bone-Pro2™, Digestif®, Gamalate®, Magnesium-Pro™, Mito-Pro2™







Melanocyte stimulating hormone


Milk protein

Bone-Pro2™ • Order hotline: 1-866-800-4677 • e-mail:

Minerals (general)

Min-Mouth™ (mouthwash), Volt-Pro™


ACF228™, DIM-Pro2™, MZS™, Prostate-Pro2™, Selenium-Pro™, Thym-Uvocal®








ACF228™, Can-C™ Plus

Solasodine glycosides

BEC5 Curaderm®



Sublingual products

Oxytocin, sermorelin




1st Line™

Nettle root extract



Niacin (nicotinate, niacinamide, vitamin B3)

Picamilone, Xan-Pro™

Natural brands: Armour®, ERFA®, West® (Nature®)

Nicotinamide adenine dinucleotide


Nootropil®/ Nootropyl®


Nordihydroguaiaretic acid (NDGA)

ACF228™, Digestif®

Thyrotropin releasing hormone


Omega 3 (DHA)


Tribulus terrestris


Omega 6 (linoleic acid, GLA)




Omega 9 (oleic acid)




Oxythiocynate (OCSN)

1st Line™

Parent Essential Oils (PEO)


PABA (para-aminobenzoic acid)


Panthenol (pantothenic acid)



Cerebrolysin®, GHRP2, GHRP6, peptide bioregulators, sermorelin, TRH, Youth Gems®

Synthetic brands: Eutirox® (T4), T3-Pro® (T3) Supporting agents: Peptide bioregulator (Thyreogen®)





Vitamin A (beta carotene, palmitate)




Vitamin B1 (thiamine)


Vitamin B2 (riboflavin)


Vitamin B3 (niacin, niacinamide)


Vitamin B6 (pyridoxal, pyridoxine)

ACF228™, Andro-Pro™, DIM-Pro2™, Gamalate®, pyridoxamine



Pomegranate extracts



Gerovital®, Potassium-Pro™

Vitamin B12 (cobalamin)

DIM-Pro2™, Neo40®



Vitamin B17




Vitamin D3 (cholecalciferol)

Bone-Pro2™, D3, Prostate-Pro2™

Vitamin C (ascorbic acid)

Digestif®, MinSaw™, Neo40®

Vitamin E (tocopherols)

Can-C Plus™, DIM-Pro2™, Prostate-Pro2™

Vitamin K2 (menatretrenone)



Digestif®, Symprove®

Procaine (Novocain®)


Pygeum africanum


Pyroloquinoline quinone






Water based






Red clover herb extracts





Andro-Pro™, Can-C Plus™, Mito-Pro2™, MZS™, Thym-Uvocal®, Zinc-Pro™

Retinolic acid (tretinoin)


Ribonucleic acids (RNA)

Cerebrolysin®, NeyDent® toothpaste

Salicylic acid

BEC5 Curaderm®



Saw palmetto (Serena Repens)

MinSaw™, Prostate-Pro2™ • Order hotline: 1-866-800-4677 • e-mail:



Dr. Aubrey De Grey “IAS has shown great vision and

Garry Gordon, MD, DO, MD (H)

Jonathan Wright, M.D.

“I am a 77 year old Physician

“Every adult has the right to take

Nicholas Perricone, M.D. “IAS is an outstanding resource

leadership, as an organisation

who has practiced medicine

care of his or her own personal

focused mainly on the

for nearly half a century.

health as he or she chooses.

date news and information

provision of contemporary

My antiaging research has

In the 20th and 21st centuries,

on healthy aging. They also

medical interventions against

permitted me to overcome

this universal human right

offer products of the highest

aging, and in also supporting

serious health problems.

has been nearly obliterated

integrity and efficacy. In fact,

the SENS Foundation’s efforts

Everyone can do this, but it

by an ocean of nanny-state

IAS is the world’s greatest

to hasten the development of

requires specialized knowledge

regulation and deliberate

source (often the only source)

much more powerful future

and the highest quality

suppression of information by

for the most cutting edge and


products. IAS is a vital link in

bureaucracies, with hidden

advanced nutrients to ensure

my antiaging program because

and not-so-hidden agendas.

optimum health span and

they continually provide both

International Antiaging

maximum life span.”

accurate information AND the

Systems is a beacon of useful

high quality products we all

health care information and

require, if we are to achieve

a literal island of freedom of

our maximum intended

health care product choice in

useful lifespan.”

our otherwise un-free health

for the finest, most up-to-

care world.”

Thierry Hertoghe, M.D.

“IAS is one of the pioneering societies in antiaging medicine...” Thierry Hertoghe, M.D.

“IAS has a history of making throughout the world crucial, but difficultly accessible medications available to patients. IAS is one of the pioneering societies in antiaging medicine that has

See all professional and public testimonials at:

50 // Order hotline: 1-866-800-4677 // e-mail:

helped this new medical specialty move forward.”


PAYMENT OPTIONS AND CONTACT DETAILS The IAS Group offers a wide range of payment options to make the completion of your order as easy as possible.

Payment options for

Other sites in the IAS Group,, and accept the following method of payments:

Pay by VISA credit card

Pay by PayPal

Use an electronic check via CHECK2PAY

Pay by VISA

(US banks only) BANK WIRE


Pay via Bank Wire

Pay by American EXPRESS

Pay by Debit Way


(EU banks only)

Pay by Debit Cards

WEBSITES (all of our products in one place; English language) (our nutritional products; English language) (our smart drugs and nutrients; English language) (our peptide bioregulators; English language) (our nutritional products; Japanese language)

EMAIL (English language) (Japanese language)

PHONE USA: 1-866-800-4677 (orders only) Japan: 050-553-29606 UK: 0208-123-2106 ROW: +44-208-123-2106

1-415-992-5563 (enquiries)

Please note: Our customer care team is available from 9am till 6pm GMT Monday-Friday. Outside of these times your call will be handled by our out-of-hours answering service or go to voicemail.

MAIL Unfortunately personal checks and money orders cannot be accepted at this time. Please contact our customer service team if you need any assistance in placing your order. • Order hotline: 1-866-800-4677 • e-mail:


Peptide Power Use Endoluten® to extend telomeres, harness your biological reserves and rejuvenate your pineal gland. Endoluten® has been shown to regulate pineal gland function: · Increase melatonin production · Improve immunological parameters · Stimulate antioxidant and anti-cancer defences · Restore reproductive function · Increase lifespan in animals · Provide geroprotective effects in humans

Endoluten® 20 Capsules $89.99 ONLY $80 per pack when you buy 3 or more *Offer valid until August 31st 2015

*Restrictions may apply in some countries. All information is educational and does not replace your physician’s advice and is subject to IAS terms and conditions which may change without notice.


Aging Matters Issue 4, 2015  

Take a look at the probiotic Symprove, and learn more about calorie restriction mimetics from Marios Kyriazis. Dr Richard Lippman also tells...

Aging Matters Issue 4, 2015  

Take a look at the probiotic Symprove, and learn more about calorie restriction mimetics from Marios Kyriazis. Dr Richard Lippman also tells...