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Duchenne Muscular Dystrophy Case Study
Duchenne Muscular Dystrophy (DMD) is a lethal genetic X linked disease results from the mutation in the reading frame of the dystrophin protein, and it affects mostly boys in their muscle and cardiopulmonary function. Although there are no effective treatments to cure DMD patients right now, scientists consistently explore more methods to come up with the practical treatments. One of the most popular and valid approaches is a geneediting therapeutic method CRISPR/Cas9 Genome Editing. It adapts from the natural systems in bacteria, and it can generate targeted gene modifications to target specific DNAsequence. Then it introduces shifts within exons to restore the reading frame, so it can express a partial functional dystrophin protein.... Show more content on Helpwriting.net ... Secondly, although both studies use CRISPR Cas9 as an agent to treat the DMD genetic disease, the principle of the mechanism is different. Young et al. used the normal bacterial protein Cas9 as a source to modify DMD; however, Lee et al. developed non viral Cas9 to induce HDR. The two methods obviously would have two different outcomes. Hence, the third difference between them was the phenotype expressed after the treatment. Yong et al. can restore a functional dystrophin protein by reframing the gene, but the method could only reduce a phenotype similar to Becker Muscular Dystrophy (BMD) phenotype. Lee et al. corrected the dystrophin mutation, including point mutation and small deletions, too their wild type sequence, which could regenerate fully functional wild type dystrophin. The advantage of both studies is that both method have tested on in vivo and in vitro, which allows the future studies to work on the development of ex vivo gene correction so that a better treatment for DMD could be generated. However, both studies still have some defects relatively. For example, the protocol of the Yong et al. study was unclear, which is significant for DMD patient as the misleading protocol could be fetal to the patients. Although Lee et al. mentioned that CRISPR Gold did not cause any inflammation or weight loss after multiple injection, it was not sufficient to suggest that the
Essay On Physics After The Discovery Of The Atom
PARTICLE PHYSICS AFTER THE DISCOVERY OF THE HIGGS
The world of physics had been developed a well established model of the atom. The standard model had been pretty well tied up , with its group of 16 elementary particles and their nice set of rules describing how they should interact. Physicists had observed until the Higgs discovery, 16 of these particles. The crowd was already beginning to desperate for a 17th particle that would send the model in new and wild directions (supposedly). But the Higgs particle ruined the hopes and expectations of everybody: it turned out to be very ordinary: its behavior was just like the model said it would act, obeying every theorized rule [2]. Therefore, the Standard Model is vindicated. And this was a... Show more content on Helpwriting.net ...
The weak force, on the other hand, is associated with particles called W and Z bosons, very massive comparing to the other particles.
The Higgs mechanism is thought to be responsible for this, now that the existence of the particle is a fact: if we recognize the existence of the Higgs field, the W and Z bosons mix with this field, acquiring mass, explaining the reason of why the W and Z bosons have mass. This unifies as well the electromagnetic and weak forces into the electroweak force. [4]
An interesting side effect, much less important than the discoveries, indeed, but with enough importance for itself, is the validation of the large amounts of effort and money invested in the equipment like the LHC. This flattens the road for the investment in the next generation of scientific machinery to keep researching. After analyzing the facts, this money is going to be very needed in the near future. It has been theorized that dark energy is the bulk of the energy of the universe, and the dark matter and energy existence is neither explained by the Standard Model. This model can´t explain gravity or the neutrino mass. Nowadays, scientific community knows that the Standard Model is an approximation of another theory, more comprehensive and able to explain the Higgs mass with a most natural approach. The reason is that the measured mass of the Higgs is about 100 million billion times smaller than the value suggested by
The Psychological Effects Of Colorblind Racism In Schools
Throughout American history, racism has been a prominent problem. From the time of the country s founding, the people of the United States have dealt with religious persecution, race based slavery, Jim Crow laws, border wars, and many more forms of discrimination. The minority population, or the non white population, have been treated unfairly from the time our country was founded until current times. All of these misjudgments of minorities have left an impact on our history, but most importantly, on the people that played a role in the different situations. When thinking of racist actions, the majority of citizens would agree that it is unfair, but not many would stop to consider the psychological effects racism could have on someone s mind. Particularly, the psychological effects of racism on young people. Racism occurs in everyday places, everywhere around the United States, including primary schools, secondary schools, and in higher education. The education system in America has been changed by several people in power in order to reduce the amount of prejudice in classrooms, but that does not mean it does not still exist in today s schools.
There are several types of racism that happen particularly inside schools. One example is colorblind racism. As written on by Dipti Desai, colorblind racism is the theory that racism no longer exists, and that all citizens are presented with equal opportunities. Many scholars believe that the theory of colorblind racism only adds
Volunteering and Attitudes Toward Social Welfare Spending...
Volunteering and Attitudes Toward Social Welfare Spending
Despite extensive research having been done on explaining why some individuals are more likely to support spending on social welfare than others, to this date, no one has examined the effect that a person s level of volunteerism has on support for spending. However, the level of community involvement is worthy of consideration as an explanation for support for social welfare spending because, as has been reported by previous research, volunteers often find that structural problems exist that can only be remedied by government intervention. Using data from the 1996 General Social Survey, this research tests the hypothesis that the more areas in which a person volunteers, the ... Show more content on Helpwriting.net ...
Furthermore, a large portion of the federal government s budget is reserved for spending that seeks to improve the general welfare of citizens, such as money spent on fighting drug addiction and solving urban problems.
Despite the assistance that welfare provides, many people are opposed to its expansion. In 1996, the welfare system underwent significant changes that reduced benefits and reformed the nature of several programs (Welfare Reform). Debate on this topic continues to the present day. Claiming that the country needs to remedy the ever growing gap between rich and poor, some activists (as well as the poor themselves) clamor for financial support from the government in order to level the playing field. Another way to increase the quality of life for the poor, however, is through volunteering, a method often supported by those who disagree with an expansive government or do not trust the sometimes ineffective federal bureaucracy. Although seemingly contradictory, it is completely plausible that volunteering would cause an individual to support an increase in social welfare spending because he or she may come to realize through volunteering that some problems are too vast to be cured by the work of a few individuals.
By examining the relationship between an individual s level of volunteerism and his or her support of social welfare spending, this research
Women s Rights By Doris Humphrey And Ruth St. Denis
As ballets were about telling stories or formulating movements, modern dance broke the rules and started to focus more on individual expressions. Loie Fuller (1862 1928), Doris Humphrey (1895 1958), and Ruth St. Denis (1877 1968) were pioneering women who took a stand and used their dance performance to speak up for women s rights. Using dance, they significantly contributed to the Feminist movement in which they embraced self expression and creativity so that women could be acknowledged in the dance field and in the society as a whole. During the late nineteenth and early twentieth century, they found for women s rights by taking dance to a new form, and creating dances to speak directly and intimately to the viewer (Au 89). Loie Fuller, Doris Humphrey, and Ruth St. Denis demonstrated the transformation of dance with their innovation of costumes and stage lighting, incorporation of foreign cultures into performance, and creation of natural movements and individual expression that rejected the formal structures of ballet to deform a woman s body, allowing women to be free from stereotype of a traditional woman.
In the 19th century, women were seen as a fragile, weak figure who always depended on men. Rules for dressing were very strict as women had to wear a tight corset with their hair tied up at all times; the only time a woman was allowed to wear her hair down was at home for her husband. They did not have a voice in the society and they were especially on the
What Were The Impact Of The Columbian Exchange
Impact of the Columbian Exchange
The flow from east to west Disease
The biggest impact of the Columbian Exchange after the introduction of new diseases into the North and South America. When the first Native Americans arrived across the Bering land bridge (North South America) between 20,000 and 12,000 years ago, they brought few diseases along with them.
Soon after 1492, some of the disease were introduced including smallpox, measles, mumps, whooping cough, influenza, chicken pox, and typhus to the Americas. Adults and children were affected by wave after wave of epidemic, in the larger centres of highland Mexico and Peru, many millions of people died. The Native American population died out completely, between 1492 and 1650, but 90 percent of the native Americans had died due to various diseases.
This loss is considered among the largest disasters in human history. By killing the Americas of much of the human population, the Columbian Exchange disturbed the region s ecological and economic balance. The decline in population by Columbian Exchange directly caused a major labour shortage throughout the America, which also increased the demand of African slaveryon a big scale in the America. From 1650 the slave trade had brought new diseases in America... Show more content on Helpwriting.net ... Recently zebra mussels from Black Sea, stowed away in ballast water ships, invaded North American waters, they blocked the water lines of factories, nuclear power plants in the regions of Great Lakes. Just after the arrival of Christopher Columbus s ships in America in 15th century resulted in worldwide exchange of disease, crops and animals in the 20th century practice of ships using water as ballast helped to unite the formerly diverse world s harbours. Similarly, air transport allows the spread of insects and diseases that would not easily survive
Hawaii Coral Reef
The purpose of this research is to apply the knowledge learned about the ecology of the Hawaiian Coral Reef to a real life situation. The coral reef stretches over 1,000 miles in the Pacific Ocean. In the Pacific Ocean, near the 124 islands of Hawaii, is the Hawaiian Coral Reef, which covers nearly 1,200 miles. Out of all the coral reefs in the world, the Hawaiian reef consists of 85% of all reefs. Coral Reefs are made of organisms, coral, and limestone skeletons. 25% of organisms are not existent anywhere else in the world. Abiotic factors are nonliving things, and abiotic factors of a coral reef are depth, light, wave motion, salinity, and temperature of the ocean. Biotic factors, living factors, is the whole coral reef, Show more content on Helpwriting.net ...
Primary producers produce their own nutrients, and make their own food through photosynthesis. Those organisms are plankton and sea weeds. The second on trophic levels are the secondary consumers such as smaller fish and sea urchins. Third on the trophic levels are decomposers. Decomposers are lobsters and sea turtles. Tertiary consumers are the top of the food chain, they are sharks and bigger fish. Predation is major in a coral reef because there is so much food supply. Mimicry is used to keep the predators away but wearing bright
The Effect Of Nutrition On Early Children s Development...
The influence of nutrition on early child s development and health
Danuta Brodzinska
ECE1700 Advanced Curricula
Professor: Eva May
Tuesday, July 21, 2015
Research Essay Outline
Introduction
A) The importance of nutrition on child s development and health .........................3 B) Malnutrition .................................................................................... 3
Body paragraphs
1.Physical development ........................................................................ 3 A) Important nutrients, vitamins and minerals for physical growth ............... 4 B) Needed calories ........................................................................5 C) Effects of inappropriate nutrition on the physical development ................ 6
2. Cognitive development ......................................................................... 6 A) Process of brain development in early years .......................................6 B) The role of iron and iodine on the cognitive development ....................... 7 C) Effects of inappropriate nutrition on the brain development .....................7
3. Social developmental development ............................................................8 A) The role of friendship in childhood .................................................. 8 B) Effects of inappropriate nutrition on the emotional and social development ...8 C) Effects of breastfeeding on child s development and health ......................8
Conclusion
A) Effects of poor nutrition on the child s development and health ..........................9
B) Benefits from early nutrition interventions .................................................. 9
Children s development is influenced by the genes they inherit and psychosocial and
The Role Of Socialization, Gender, And Education As A...
Socialization, Gender, and Education as a social institution have all been topics that have been heavily discussed in the classroom. Each of these sociological aspects of society help create ideologies and norms in particular as to the role gender plays in the household and in the workplace. From the extended interview on Adam Belaid, it has become evident that the educationplays the largest role in socialization. In particular, the public educational institutions that have been founded on the principals of the state. Particularly, educational institutions and their effect on its students views on gender. Through an analysis of the interviewee, Martin s Becoming a Gendered Body: Practices of Preschools , and Bowles Education and Inequality it is evident that the educational institution plays the greatest role in the socialization of an individual. Adam Belaid is currently a software engineer at Riot Games, whose job is primarily in back end development and program execution. He was educated in several countries where each country has a slightly different sociological norm. His adolescent education was in France, Saudi Arabia, and Jordan; his high school education took place in what he defined as a small school that taught an Advanced Placement (AP) and International Baccalaureate (IB) curriculum in Arizona. His undergraduate education took place at Virginia Tech with a major in Computer Science. Adam identifies himself as a practicing Muslim with his parents
Violence in Todays Society
Lisa M. Allen
Enc 1101
September 14, 2008
Today s Violence and Its Many Causes
Violence in today s society is at an all time high. There are many causes for the increase in violence in our society. Violence is defined by (1) criminal law, the illegal use of unjustified force, or the intimidating effect created by the threat of this (2) the use of physical force to injure somebody or damage something (Encarta Dictionary: English North American Version). Rape, homicide, assault and burglary with a weapon are all forms of malicious legal violence that plague our communities in irrevocable ways. In fact violence in the form of homicide is the second leading cause in youth ages fifteen to twenty four, third leading cause in ages ... Show more content on Helpwriting.net ... , PhD, MS, CAP, CAPP, Director of Operations Sutton Place Behavioral Health. Powerpoint Presentation. Florida Statewide Prevention Conference 2007). Since the 1950s, thousands of studies have been done on the effects of violence in television and movies. The majority of these studies conclude that: children who watch significant amounts of television and movie violence are more likely to exhibit aggressive behavior, attitudes and values (Illinois Center for Violence Prevention. Media and The Changing World Report. May 2005. Page 12). Per the Congressional Public Health Summit, 2000, young children 1.) are more easily impressionable 2.) have a harder time distinguishing between fantasy and reality 3.) cannot easily discern motives for violence and 4.) learn by observing and imitating. Finally there are plenty of studies going on right now researching how violent video games can cause people to have more aggressive thoughts, feelings, and behaviors; and decrease empathetic, helpful behaviors with peers. With the over stimulation of the brain, it requires children to go above and beyond the last experience in order to feel the same endorphins. With the need to out do the next guy and with the motto if it bleeds, it leads , then what do we expect for the next generation of youth to be faced with?
In generation Y we are seeing a major increase in
Xenophobia In District 9 Essay
Exploring Xenophobia in District 9
Thirty years ago, aliens arrive on Earth, not to conquer or give aid, but to find refuge from their dying planet. Separated from humans in a South African area called District 9, the aliens are managed by Multi National United, which is not concerned with the aliens welfare but will do anything to master their advanced technology. When a company field agent Wikus contracts a mysterious virus that begins to alter his DNA, there is only one place he can hide: District 9. The film was directed by Neill Blomkamp and starred Sharlto Copley (Wikus). It begins as a documentary style investigation and then as the film continues it becomes more conventional and character driven following Wikus and his... Show more content on Helpwriting.net ...
In the movie, there are signs saying either no prawns or no humans and the humans show a major sign of xenophobia towards the prawns. In this day in age we see a lot of hatred towards foreigners, in particular, terrorists. In the beginning of the movie you see Blomkamp interviewing the humans about the prawns. They show a great level of hatred and disgust for the prawns intruding on their town. In the real world, we see this same form of hatred or disgust from certain people about the immigrants and refugees intruding on and taking over many American s jobs. Blomkamp wants to push the issue that there is great hatred throughout the world today. The main reason he produced the film in Johannesburg was because there were high tensions between native south Africans and Zimbabwean refugees. He wanted to try to make the town he grew up in great again. Blomkamp wanted to open people s eyes with the use of science fiction to show that in some ways we treat other humans like the humans treated the prawns. Differential Criticism studies works by and about oppressed groups, including ethnicities, women and homosexuals. The focus is particularly on how oppressed people and their artistic or intellectual productions have been marginalized, stifled, or demonized, and how preoccupations with difference (framing them as the Other ) have shaped the portrayal of these groups (Fourteen Critical Approaches for
Anne Of The Indies
There has been much romanticizing of pirates in media over the years. Honorable and dashing men pitted against evil and cruel pirate captains, etc. Some films offer a more accurate portrayal of piracy life than others. The 1951 Jacques Tourneur film, Anne Of The Indies is such a film. The film centers around a woman captain who is fooled into trusting a captured prisoner, Pierre, as he secretly tries to capture her for arrest. While the filmis entertaining in itself it also provides us with some historical insight on women s interaction with piracy, Captain Blackbeard, and general life of a pirate crewman. . The main character of the film, Captain Anne Providence was a peculiar character. Her name might strike the thought of Anne Bonny, a... Show more content on Helpwriting.net ... The over romanticization that follows the genre was not as heavy. Yes, there was a love story but it wasn t the usual, repeated love story. Which let the characters to be explored with. Anne proved to be a lass capable of her own decisions much like the women in history who led ships themselves. Blackbeard had uncommon characteristic not usually found in his portrayals that might have actually given the audience more insight in the struggle of a pirate. As well as a man more than just his myths. There is of course films, tv shows, and such that provide a more accurate description of life as a pirate than Anne Of The Indies. The history in the movie proved to be fairly accurate with only a few creative decisions here and there. At least they avoided the traditional sawing of the leg scene and only had one eyepatch. Got to give them
Patrice Lumumba Killing In Nigeria Research Paper
Gowon had seceded with the North, maybe the protracted civil war that started after their revenge coup would have been avoided. According to Forsyth (1969), thousands of Igbo people were massacred in pogroms in the Northern parts of Nigeria and up to 2 millions of Igbo people died during Nigeria/Biafra civil war; mostly women and children died of starvation as a result of the use of the policy of starvation as a weapon of war and blockade of the separatist Biafra Republic. The human devastation which the world is witnessing today in Syria, as a result of the fact that starvation is being used a weapon of war is horrible (UN (2016).
This is not an isolated situation in Nigeria or Africa. Collins (1992) argued that the double elimination of the United Nations Secretary General Dag Hammarskjold and the Prime Minister of Congo Patrice Lumumba were efforts at the destruction of peace coming from Dag Hammarskjold and freedom of the Congo in the hands of Belgium coming from Patrice Lumumba. According to Nzongola Ntalaja (2011), Patrice Lumumba, the first legally elected prime minister of the Democratic Republic of the Congo (DRC), was assassinated (...) on 17 January, 1961. This heinous crime was a culmination of two inter related assassination plots by American and Belgian governments, which used Congolese accomplices ... Show more content on Helpwriting.net ...
The removal of village democracy in Igbo land came at a time the colonial soldiers and administrators wanted to pacify the Igbo s. The most crucial aspects of colonialism which will remain in producing intractable problems in Nigeria and among Nigerians are the amalgamation of the peoples of the 3 British colonies who had little or nothing in common; in terms of political system, language, culture, history etc. ; the nature and roles of the military and foreign political
