Scapho 150mg injection

SCAPHO 150MG DESCRIPTION Secukinumab is a generic form of brand name scapho 150mg and scapho 150mg injection is a type of biological therapy which prevent the function of IL-17A proteins. This activity alters the immune activity and inflammation which cause the symptoms of psoriatic arthritis.

Scapho 150mg is used as prescription drug given by a doctor rheumatologist for adults with psoriatic arthritis and ankylosing spondylitis.

INDICATION Scapho 150mg injection prescribed for the therapy of patients with following condition : • Plaque Psoriasis • Psoriatic arthritis • Ankylosing spondylitis MECHNAISM OF ACTION Secukinumab consist of human IgG1 monoclonal antibody whichcarefullyconnects to the interleukin-17A (IL-17A) cytokine and prohibits its concomitant with the IL17 receptor. IL-17A is a naturally appearing cytokine included in normal inflammatory and immune responses. Secukinumab prevents the release of proinflammatory cytokines and chemokines.

PRODUCT DETAILS Brand :Scapho Ingredients : Secukinumab Strength : 150mg Manufactured : Novartis India Ltd Package : 150mg in 1 vial

Scapho 150mg

ADME Absorption: high plasma concentration for single dose is 6 days and weekly dosing for first month is 31-34 days Distribution: volume of distribution is 7.1 – 8.6 in IV administration Metabolism: Intracellular catabolism is the drug metabolized Elimination: half-life is 22-31 days DOSAGE MANAGEMENT Plaque Psoriasis : Initial dose for the patients is given 300 mg SC at weeks 0, 1, 2, 3, and 4 initially at week 8, given 300 mg SC once monthly The prescribed dose for plaque psoriasis is 150 mg may be acceptable for some patients Psoriatic Arthritis : The recommended dosage for Psoriatic arthritis for other patients, administer with or without a loading dosage by SC injection Scapho 150mg the recommended dose with loading dose administrated 150 mg SC at weeks 0, 1, 2, 3, and 4 and q4wk thereafter Scaphothe recommended dose without loading dose administrated 150 mg SC q4wk.

Dosage of 300 mgshould be taken by patient ifcontinues to have active psoriatic arthritis, May be given with or without methotrexate.

Ankylosing Spondylitis : The recommended dose is given with or without a loading dosage by SC injection Scapho the recommended dose with loading dose is administrated 150 mg SC at weeks 0, 1, 2, 3, and 4 and q4wk thereafter PRECAUTIONS • When using Scapho 150mg injection will increased risk of infections; use with caution in patients with chronic infection or a history of recurrent infection • Do not take vaccination of Secukinumab recipients with live virus vaccines because of probability of transmission of infection by vaccine • When using scapho 150mg medication then Anaphylaxis and cases of urticaria resulted; if this appears, discontinue scapho 150mg injection immediately and start anaphylaxis treatment • The treatment with Secukinumab should not be given to patients with active tuberculosis infection

Plaque Psoriasis

SIDE EFFECTS • Swelling under your skin • Sores on your genital or anal areas • Painful skin sores • infections

• Nasopharyngitis • Diarrhea • URT infection • Rhinitis • Oral herpes • Pharyngitis • Urticaria • Rhinorrhoea DRUG INTERACTION CYP450 substrates co administration with scapho 150mg injection may altered by increased levels of certain cytokines Live vaccinations co administration with scapho 150mg should be avoided CONTRAINDICATION Patients having Serious hypersensitivity reactions to the active substance or to any of the excipients PREGNANCY Pregnancy category is B Use the scapho 150mg injection with caution during pregnancy LACTATION Excretion into human milk is unknown. Use with caution while administrating scapho to a nursing woman STORAGE Store the drug at 20°C – 80°C Store in original carton and protect from light until the time of use MISSED DOSE If failed to take a dose, patients should consult with medical practitioner and follow the instructions given by them.

Or swap the missed dose and continue the regular dosing schedule.

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