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PRIME TIME
March 2021
Side Effects Of Green Things: The Rare Downside Of Cannabinoids
Shellie Rosen, DOM
Herb Doc
Shellie Rosen is a Doctor of Oriental Medicine. She can be reached via her website at Bodyvolve.com
Receptor “TRPV1” is necessary to prevent nausea and vomiting because it affects gastric motility. TRPV1 receptors can be re-activated by hot showers (via cutaneous heat). In other words, cannabinoid use leads to altered gastric function via a reduction in TRPV1, which leads to symptoms of nausea and vomiting resolved only by (activating TRPV1) cutaneous heat. CHS often does not respond to antiemetic drugs but ends abruptly after cessation of cannabis.
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Cannabinoid receptors exist throughout the body, including the gut. For the receptors in the brain, users get a sense of anti-nausea sensations. However, the receptors in the gut cause some individuals to feel very sick. CHS is tricky because of its paradoxical reactions. Some patients use cannabinoids to treat nausea and vomiting, unaware that cannabinoids may cause their symptoms. For CHS sufferers, it appears that repeated cannabinoid activity at a receptor called “TRPV1” leads to desensitization.
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Cannabinoids with a high Tetrahydrocannabinol or THC content are likely the key culprit in CHS. CBD or Cannabidiol often carries a much lower or, in some cases, an undetectable THC amount. THC induces a psychoactive component unique to “Marijuana” or “pot.” On the other hand, CBD is not psychoactive and is used for pain, neurological issues (including epilepsy), psychological conditions, and alleviating chemotherapy’s side effects. Since fat cells harbor THC, cannabinoid release may occur long after intake. Consider this if switching to CBD. The effects of cannabinoids may continue after THC cessation. Cannabidiol may trigger CHS in rare cases, but if it has little to no THC, it is unlikely to cause CHS. CBD may offer solutions for those who suffer from conditions reliant upon addictive psychoactive drugs such as opioids. Cannabidiol products may be appropriate for those not seeking psychoactive change but physiological relief.
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S R U O E K I L YL I M AF R U O Y TA E R T E W
annabinoid Hyperemesis Syndrome (CHS) began as an unnamed medical phenomenon. The cluster of symptoms, including nausea, vomiting, and stomach pain, stumped physicians for years. It was not until 2004 that physicians in South Australia built a case that the culprit was routine and longterm use of cannabinoids. The main symptoms of chronic vomiting and extreme nausea are present in other conditions; however, patients’ reliance on scalding hot showers for relief was unique. Some medical practitioners are not aware of CHS, nor do they have clinical guidelines for treating it. This article supports the benefits of safe cannabinoid use while alerting you to potential rare side effects.
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The average time to arrive at a diagnosis for CHS is, on average, years. Physicians note that many patients are in denial about their diagnosis. Discussing CHS can be challenging due to stigmas against cannabinoid use and a lack of knowledge about potential side effects. If you respond favorably to safe cannabinoid products without unwanted side effects, by all means, carry on. An individual with questions about their ability to tolerate persistent, long-term, or any cannabinoid use at all shall carefully evaluate their symptoms after lengthy periods of discontinued use. The undiagnosed suffering from CHS has caused many to be ignored or treated with improper drug therapy and surgery.
This knowledge, shared in an open dialogue, might be a lucky answer for a CHS sufferer. Abundant Blessings to an open heart and mind while helping those in need! Dr. Shellie L. Rosen, DOM., L.Ac.
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