han altae-tran han.altaetran@gmail.com | (703) 350-3466 LinkedIn://han.altaetran
EDUCATION
RESEARCH EXPERIENCE
STANFORD UNIVERSITY
STANFORD BIOENGINEERING - PANDE LAB
M.S. IN ELECTRICAL ENGINEERING
RESEARCH INTERN
Expected June 2016 Cum. GPA: N/A
B.S. IN PHYSICS | MATH Expected June 2015 Minor in Creative Writing: Poetry Minor in Computer Science Cum. GPA: 3.90 / 4.0
JAMES MADISON HS Grad. May 2011 National AP Scholar Award
COURSEWORK GRADUATE Machine Learning Probabilistic Graphical Models Information Theory I Convex Optimization I+II The Fourier Transform Quantum Field Theory I General Relativity Neural Circuits Theoretical Neuroscience Biochips
UNDERGRADUATE Honors Multivariate Calculus I+II+III Real Analysis I+III Stochastic Processes Statistical Mechanics I+II Electromagnetism I+II Physical Chemistry I Organic Chemistry I Circuits + Lasers + Cryogenics Labs
SKILLS PROGRAMMING Experienced: Java • Bash Shell • C • Matlab Python • PyMol • LATEX• CVXOPT Mathematica • HTML 5 Familiar: JavaScript • JQuery • CSS • MySQL
Nov 2013 – Present
• Developed feature extraction method for detecting amino acid pairs whose distances correlate to future large scale conformational change. [Link://pdf ] • Developed Kullback-Leibler divergence clustering method for identifying regions that change between protein macrostates. • Developed a Bayesian optimization protocol for improving molecular dynamics forcefield parameters. • Implemented statistical reweighting of Boltzmann constants for reevaluating the objective function of forcefield optimization without running additional simulations.
VACCINE RESEARCH CENTER - STRUCTURAL BIOINFORMATICS CORE SECTION SUMMER INTERN
June 2012 – Sept 2012, June 2013 - Sept 2013
• Computationally designed VRC01 antibody variants using homology modelling with x-ray crystallography data. • Helped develop correlation based methods for detect the presence of novel and known anti-HIV-1 antibodies in serum using the serum’s ability to neutralize HIV-1 pseudoviruses. • Reduced the number of viruses required to perform above detection using neutralization based clustering, A* enumeration, and Monte Carlo methods. New virus panel was 15% smaller than original panel. • Used above methods for characterizing the target sites and recognition modes of newly discovered anti-HIV-1 antibodies in donor CAP-256. • Analyzed framework mutations in anti-HIV-1 antibodies. • Performed antibody-antigen contact analysis, Shannon entropy comparisons, and structure based clustering. • Designed residue level analysis of VRC01 class antibodies for structural and protein sequence level conservation. Further statistical analysis of structural data. • Performed ELISA binding experiments for anti-gp120 antibodies.
GEORGE MASON UNIVERSITY - BIOINFORMATICS AND COMPUTATIONAL BIOLOGY SUMMER INTERN
Aug 2011 - Sept 2011
• Created neuronal models using Hodgkin-Huxley dynamics, Connor-Stevens dynamics, cable equations, and compartmental modelling.
UNIVERSITY OF ILLINOIS AT URBANA - MICRO AND NANOTECHNOLOGY LABORATORY SUMMER INTERN
June 2011 - Aug 2011, Aug 2010 - Sept 2010
• Maintained and imaged cardiac muscle cells derived from the ventricle, apex, and atrium regions in order to determine if contraction dynamics differ between cardiac muscles cells from these groups. • Fabricated PDMS microchambers.
ANALYSIS
NORFOLK STATE UNIVERSITY
Graphpad Prism • BioEdit
SUMMER INTERN
DESIGN Photoshop • FL Studios • Ableton Live
June 2010 - Aug 2010
• Fabricated and characterized cobalt ferrite nanoparticles.