What is tramadol Ultram 100mg? Tramadol is a narcotic-like pain reliever. Tramadol is used to treat moderate to severe pain.The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.Tramadol may also be used for purposes not listed in this medication guide. You should not take tramadol if you have used alcohol, sedatives, tranquilizers, or narcotic medications within the past few hours