Protects cardiovascular system Protects nervous system
Slows down arterial aging
Enhances exercise performance
Detoxification Boosts immunity Skin whitening
Antioxidant
N-Acetylneuraminic Acid (Sialic acid)
Anserine Carnosine
HMO (3’-SL & 6’-SL)
Customization Service
Anti-glycation
Promotes brain development
Lowers uric acid
Promote neural development
Antioxidant
Anti-glycation Protects nervous system Boosts immunity
Enhance immune function
Anti-aging
Anti-aging
Regulates intestinal flora
Antioxidant
Supports probiotic growth
Anti-fatigue
Anti-aging
Anti-fatigue
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nucleotide
CAS 1094-61-7
Molecular Weight 334 22
Product Information
Molecular Formula Appearance Structure
C11H15N2O8P
Whitetooff-whitecrystalline powder
NMN (β-nicotinamide mononucleotide) is a naturally occurring nucleotide in the body and a direct precursor to NAD+ NAD+ is a crucial coenzyme involved in human metabolism, but its level decreases with age Research has shown that taking NMN orally is the most effective way to supply NAD+, activate longevity proteins known as sirtuins, boost immunity, and delay the effects of aging With regular use, NMN can help promote overall health and vitality
The content of NADin human body decreases with age
Mechanism
Oral intake of NMN can effectively increase the levelofNAD
NMN is a healthcare supplement that has been shown to enter cells directly through transport proteins, where it can be converted to NAD+ by NMNAT2 NMN can also be converted to nicotinamide riboside (NR) on the surface of cell membranes and then enter cells in the NR form Once inside, it can be converted to NAD+ by NRK and NMNAT2 NRKs and NMNATs are found in various organs and tissues throughout the body, with the liver containing the highest concentration Hence NMN is an ideal supplement for anyone looking to boost their cellular energy levels and support overall health and vitality
Safety
After taking 500 mg NMN, the test group showed no abnormal fluctuations in aspartate transaminase (AST) and white blood cell (WBC) count in their serum after 5 hours
Reduced Glutathione (GSH)
L-Glutathione Reduced
70-18-8 C10H17N3O6S
Product Information
Reduced glutathioneis a naturaltripeptide composed of glutamic acid, cysteine and glycine. This ingredient is present in human cells and plays a crucial role in metabolic regulation The reduced glutathione is known for its ability to activate multiple enzymes and promote the metabolism of carbohydrates, fats and proteins. Its detoxification, anti-oxidation and immune enhancing effects are widely recognized and utilized in a variety of healthcare products.
CAS Mechanism
Oral intake of GSH can effectively increase the level of GSH in blood
ROS can cause tissue fibrosis by accelerating abnormal proliferation of malondialdehyde (MDA) and 4-hydroxynonenal (HNE) GSH can prevent tissue fibrosis by eliminating ROS
Efficacy
ROS will affect lipid homeostasis regulation, block fatty acid oxidation, and cause lipid peroxidation GSH can prevent lipid peroxidation by eliminating ROS
Fifteen patients with non-alcoholic fatty liver disease were supplemented with 300 mg/day of glutathione for 4 months A decrease in plasma alanine transaminase (ALT) level was observed after 4 months
Dopachrome Glutathione dopa
ROS can stimulate the production of inflammatory factors, leading to inflamma- tion GSH can achieve an antiinflammato- ry effect by eliminating ROS
Brown spots, dark Tyrosinase spots
ROS can activate tyrosinase, leading to the production of melanin and causing skin hyperpigmentation GSH can brighten the skin by eliminating ROS
Fifteen HIV-positive patients were randomly divided into two groups One group was supplemented with glutathione (1260 mg/day) After 13 weeks, the group showed a significant decrease in inflammation factor (IL-6)
60 healthy people were orally administered with glutathione at a dose of 500 mg/day After 4 weeks, the average melanin index of 6 parts is significantly decreased compared with the control group
Ergothioneine Molecular Weight
229 3 CAS
497-30-3
Product Information
Molecular
Ergothioneine(EGT) isa natural amino acid derivative found in many plants and animals. Unlike other amino acids, ergothioneine cannot be synthesized by the human body, and thus, it can only be obtained through a balanced diet. Transporting ergothioneine into cells is made possible by a highly specific cationic transporter protein known as slc22a4 (previously known as OCTN1). With its potent antioxidant properties, ergothioneine is an effective ingredient in reducing free radicals and has a significant impact on human physiological activities.
The expression of the slc22a4 gene in different tissues of the human body
The gene slc22a4 encoding the transporter of ergothioneine is widely expressed in in various tissuesandorgans, suggesting the universal presence of ergothioneine in human body
Mechanism
Ergothioneineeffectively removes ROS from the human body.
Neurodegenerative diseases
Cardiovascular disease
Liver fibrosis
Kidney dysfunction
Skin damage
45 healthy volunteers were divided into three groups and were provided with a placebo, a low dose of ergothioneine (5 mg/day), and a high dose of ergothioneine (25 mg/day), respectively It was found that the level of ergothioneine was significantly increased in blood after 35 days, without any adverse effects EGT
The control group was fed with physiological saline, while the Aβ1-40 group was injected with amyloid protein (Aβ 140) (5 μL 400 pmol/mouse) into the hippocampus and then fed with physiological saline The Aβ1-40 + EGT group was additionally fed with 0 5 mg/kg EGT After 39 days, and it was found that EGT significantly reduced the number of Aβ deposits in the hippocampus
In vitro cultured endothelial cells were divided into four groups (control group, 30 μM 7-ketocholesterol (7KC) as the negative control, 1 mM EGT, 7KC + EGT) After 24 hours of culturing, an increase in the expression of IL1β, IL-6, IL-8 and TNFα in endothelial cells induced by 7KC was observed Addition of EGT significantly reduced the expression of inflammatory factors
Arterial endothelial cells were cultured in vitro and 2O2, resulting in treated with varying concentrations of H a significant decrease in cell viability However, upon addition of 0 5 mM EGT, a significant increase in cell viability was observed, preventing damage to the endothelial cells
bone small skeletalkidney marrowintestine muscle
Carnosine
Carnosine
Product Information
Carnosine is a naturaldipeptide composed of β-alanine and L-histidine It is widely found in human muscles and brain tissue and is an important antioxidant and anti-glycation factor in cells.
Excessive ROS and glycation end products AGEs are the main factors leading to cell damage, accelerated aging, and chronic diseases Carnosine can play a wide range of antioxidant effects by directly scavenging hydroxyl free radicals and hydrogen peroxide, chelating metal ions, inhibiting lipid peroxidation, etc.; it plays an anti-glycation effect by scavenging intermediates in glycosylation reactions and can protect cells. Protected from the effects of oxidative stress.
Carnosine helps reduce lactic acid accumulation, improve muscle endurance and nerve conduction efficiency by regulating intracellular acid-base balance and optimizing energy metabolism It has a significant anti-fatigue effect and is especially suitable for rapid recovery of physical fitness after high-intensity activities.
Mechanism
Themolecularmechanism of carnosine as an antioxidant and anti-glycation agent
The content of carnosine in skeletal muscle decreased with the increase ofage
The mechanism of carnosine in relieving exercise fatigue
Efficacy
The daily required carnosine for the low-dose group (0 12 mg/g body weight), the middle-dose group (0 23 mg/g body weight) and the high-dose group (0 69 mg/g body weight) was made into a 0 2 mL preparation, which was administered orally every day The control group was given 0 2 mL of distilled water every day for 20 consecutive days Experimental correlated with exercise time in mice conclusion:Carnosine is positively
Experiment condition: Human skin fibroblasts; Negative control: UV; Positive control: UV+ vitamin E (0 064 μM); Experimental group: UV+ carnosine (0 064 μM) ※Third-party experimental data
Experimental conclusion：Carnosine can effectively remove reactive oxygen species (ROS) in cells, and its effect is better than vitamin E
Reference: A A Boldyrev et al , Reference: A-Sawalha, et al , , 2019, 237,116905 , 2013, 93, 1803–1845
Male Wistar rats were divided into regular diet (Control), high-fat and high-carbohydrate diet (HFHCD), regular diet + carnosine supplement (L-Car), high-fat and high-carbohydrate diet + carnosine supplement (HFHCD&L-Car) group, intervention 16 weeks, to assess retroperitoneal fat weight Experimental conclusion: Carnosine can significantly reduce retroperitoneal fat weight and improve metabolic syndrome caused by high-fat and high-carbohydrate diet
