Lubrizol Brochure

Enabling Differentiated Nutraceutical Solutions with Optimized Ingredient Delivery

Lubrizol's core microencapsulation technology offers several competitive advantages:

PLANT-BASED

Minimized unpleasant taste

24.305

Mg

12

CURCUMIN

55.8457

MAGNESIUM

Controlled release

Fe IRON

PHYTOSTEROLS

26

40.078

Ca

20

CALCIUM

CAFFEINE

65.409

Zn ZINC

Enhanced bioavailability

30

Controlled interactions with other components

LUBRIZOL NUTRACEUTICALS PRODUCT PORTFOLIO

SKIN & HAIR

COGNITIVE & MENTAL HEALTH

ENERGY & ENDURANCE

CARDIOVASCULAR HEALTH

IMMUNE SYSTEM HEALTH

BONE HEALTH

For more information, visit www.lubrizol.com The Lubrizol Corporation (“Lubrizol”) hopes that you have found the information provided helpful, but you are cautioned that this material, including any prototype formulas, is for informational purposes only and you are solely responsible for making your own assessment of appropriate use of the information. TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAWS, LUBRIZOL MAKES NO REPRESENTATIONS, GUARANTEES, OR WARRANTIES (WHETHER EXPRESS, IMPLIED, STATUTORY, OR OTHERWISE), INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR REGARDING THE COMPLETENESS, ACCURACY, OR TIMELINESS OF ANY INFORMATION. Lubrizol does not guarantee how the materials referenced herein will perform in combination with other substances, in any methods, conditions, or processes, with any equipment, or in non-laboratory environments. BEFORE COMMERCIALIZATION OF ANY PRODUCT CONTAINING THESE MATERIALS, YOU SHOULD THOROUGHLY TEST SUCH PRODUCT, INCLUDING HOW THE PRODUCT IS PACKAGED, TO DETERMINE ITS PERFORMANCE, EFFICACY, AND SAFETY. You are solely responsible for the performance, efficacy, and safety of any products you manufacture. Lubrizol shall not be liable, and you shall assume all risk and responsibility for, any use or handling of any material. Any claims may not be approved in all jurisdictions. Any entity making claims related to these products is responsible for complying with local laws and regulations. Nothing contained herein is to be considered as permission, recommendation, or inducement to practice any patented invention without permission of the patent owner, and it is your sole responsibility to determine if any issues related to patent infringement of any component or combination of components relating to the information provided exists. You acknowledge and agree that you are using the information provided herein at your own risk. If you are dissatisfied with the information provided by Lubrizol, your exclusive remedy shall be to not use the information. LIPOTEC S.A.U., a subsidiary of Lubrizol. Isaac Peral 17 Pol. Industrial Camí Ral - 08850 Gavà (Barcelona) Spain Tel +34 93 638 80 00 www.lubrizol.com

LipocalTM microcapsules is a water dispersible micronized source of calcium coated with lecithin which increases calcium dispersibility and absorption.

SCIENCE There is a growing awareness of the importance of maintaining a high calcium intake throughout life, not just for bone health but also for the health of other body systems.

•Improves dispersibility •High calcium concentration •More bioavailable than other calcium sources •Non-animal source of calcium

COMPOSITION: Identity preserved soy Lecithin* PRODUCT FORMAT: White Powder or granules ACTIVE CONTENT: 33.7-39.6% elemental calcium DISPERSIBILITY: Highly dispersible

Calcium intake, particularly that during childhood, is a major determinant of bone mass in adults, and it also influences the rate of bone associated with aging. Osteoporosis, a disease affecting many millions of people around the world, is characteri- zed by bone fragility that over time leads to bone fracture.

The major benefit of calcium is preventative, mitigating the risk of developing osteoporosis during the aging process. Low dietary intake of calcium is also associated with higher risks of colon cancer and hypertension and may affect normal growth in children.

Although dairy products account for about 70% of dietary calcium, total calcium intake remains inadequate. This realization has led to the calcium fortification of an expanding number of foods.

Particularly pressing is the need to ensure adequate calcium intakes for vegetarians and for those with milk aversions.

LipocalTM microcapsules is a bioavailable non-animal source of calcium, suitable for vegetarians, that can be easily incorporated in a wide range of food applications.

Bone Health Tablets and capsules

Liquids

Powders

Infant formula

Dairy products

Imagined for life. Enabled by Science.™

In vivo efficacy 1. Calcium absorption profile

microcapsules and dairy calcium.

Four groups of five male Hartley guinea pigs weighing 400- 450g were orally administered a dose of 3.43 mg calcium/kg body weight, corresponding to two dairy yogurts of 100 grams for a person of 70kg. Blood samples were extracted before and after 10, 20, 30, 40 and 50 minutes of administration and the plasma calcium concentration was measured through Inductively Coupled Plasma Atomic Emission Spectrometry.

The absorption profile of calcium during 50 minutes was obtained and the overall uptake per time was calculated.

7 6

Lipocal microcapsules TM

5

Calcium concentration (μM)

A study of dietary calcium absorption in guinea pigs was performed at the University of Barcelona, in order to compare the bioavailability of calcium from three different sources: Tricalcium Phosphate (TCP), LipocalTM

increases calcium blood concentration in animals faster

4 3 2

A faster calcium absorption profile is

1

observed with LipocalTM

0 10

00

20

30

40

50

Time (minutes)

Tricalcium phosphate

Cow milk calcium

microcapsules compared to other sources of calcium.

Control

125

calcium

The corresponding area under the curve (AUC) for plasma calcium concentration for each formulation was estimated measuring the amount of calcium absorbed during the experimental period.

96.7

108

100

Lipocal microcapsules is a TM

highlybioavailable calcium source

83.4 75 AUC

2.

Plasma concentration curve

50

25

Results show Lipocal microcapsules is 41% more bioavailable than TCP and 15% than milk calcium.

TM

22.9

0 Control

TCP

Milk Ca

To enquire or request a sample, contact us at nutraceuticals@lubrizol.com The Lubrizol Corporation (“Lubrizol”) hopes that you have found the information provided helpful, but you are cautioned that this material, including any prototype formulas, is for informational purposes only and you are solely responsible for making your own assessment of appropriate use of the information.

TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAWS, LUBRIZOL MAKES NO REPRESENTATIONS, GUARANTEES, OR WARRANTIES (WHETHER EXPRESS, IMPLIED, STATUTORY, OR OTHERWISE), INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR REGARDING THE COMPLETENESS, ACCURACY, OR TIMELINESS OF ANY INFORMATION. Lubrizol does not guarantee how the materials referenced herein will perform in combination with other substances, in any methods, conditions, or processes, with any equipment, or in non-laboratory environments. BEFORE COMMERCIALIZATION OF ANY PRODUCT CONTAINING THESE MATERIALS, YOU SHOULD THOROUGHLY TEST SUCH PRODUCT, INCLUDING HOW THE PRODUCT IS PACKAGED, TO DETERMINE ITS PERFORMANCE, EFFICACY, AND SAFETY. You are solely responsible for the performance, efficacy, and safety of any products you manufacture. Lubrizol shall not be liable, and you shall assume all risk and responsibility for, any use or handling of any material. Any claims may not be approved in all jurisdictions. Any entity making claims related to these products is responsible for complying with local laws and regulations. Nothing contained herein is to be considered as permission, recommendation, or inducement to practice any patented invention without permission of the patent owner, and it is your sole responsibility to determine if any issues related to patent infringement of any component or combination of components relating to the information provided exists. You acknowledge and agree that you are using the information provided herein at your own risk. If you are dissatisfied with the information provided by Lubrizol, your exclusive remedy shall be to not use the information. LIPOTEC S.A.U., a subsidiary of Lubrizol. Isaac Peral 17 Pol. Industrial Camí Ral 08850 Gavà (Barcelona) Spain Tel +34 93 638 80 00 www.lubrizol.com

Ed. 25A © 2025 The Lubrizol Corporation or its affiliates.

LipophytolTM microcapsules is a dispersible form of pine tree sterols which has been microencapsulated to make them water dispersible.

SCIENCE High blood cholesterol level is the first risk factor for coronary heart disease. The cholesterol lowering effect of plant sterols is well documented in literature. Consumption of 1.5 to 2.4 grams

•Efficient cholesterol reduction •High phytosterols concentration •Readily dispersible • Stable

of plant sterols per day has been found to potentially lower LDLCholesterol by 7% to 10%.

The European Food Safety Authority (EFSA), has approved claims for plant sterols namely: i) ”plant sterols have been shown to lower/ reduce blood cholesterol with a daily intake of 1.5-2.4 g of plant sterols/stanols” and ii) ”plant sterols/stanols contribute to the

COMPOSITION: Maltodextrin, Inulin, Sucrose Ester PRODUCT FORMAT: White to off-white powder ACTIVE CONTENT: 68-75% or 87-94% phytosterols DISPERSIBILITY: Highly dispersible

maintenance of normal blood cholesterol levels with a daily intake of 0.8 g of plant sterols/stanols”.

The U.S. Food and Drug Administration (FDA) approved the following claim for phytosterols: “foods containing at least 0.4 grams per serving of plant sterols, eaten twice a day with meals for a daily total intake of at least 0.8 grams, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease“.

Due to their insolubility in water and lipids, phytosterols incorporation into foods and beverages formulations has been very challenging.

In

this

respect,

LipophytolTM

microcapsules

facilitates

incorpora- tion of phytosterols in food matrices due to its high dispersibility.

Cardiovascular Health Tablets and capsules

Liquids

Dairy products

Imagined for life. Enabled by Science.™

Cholesterol reduction cholesterol

lowering

effect

of

LipophytolTM microcapsules was studied in vivo using knock out Apo E mice in a study conducted by Dr. Blanco at the Institut de Recerca de l’Hospital de la Santa Creu i San Pau in Barcelona.

Three groups of mice were fed either i) a high fat diet (control), ii) a high fat diet

25 20

significantly reduced the concentration of VLDL+LDL cholesterol in serum compared to the control

15

10

5 0

with LipophytolTM microcapsules or iii) a high fat diet with phytosterol esters.

0 weeks

2 weeks

Control

Tryglicerides reduction in hamsters

4 weeks

Lipophytol microcapsules TM

4 weeks Sterols as Esters

250

Serum analyses were determined for

their

200 Triglycerides (mg/dL)

LipophytolTM microcapsules and raw phytosterols diets, to assess activity on triglyceride levels.

Lipophytol microcapsules TM

VLDL + LDL Cholesterol (mM)

The

Results indicate that

LipophytolTM microcapsules

150

might enhance the activity of phytosterols against hypertriglyceridemia

100

50 0 Standard diet (SV) HV +

High fat diet (HV)

Lipophytol microcapsules TM

HV + RAW PHYTOSTEROLS

Lipophytol microcapsules

Protective effect against aortic lesions

weeks of treatment. Heart and proximal aortas were removed and atherosclerotic lesions quantified.

resulted in reduced damaged aorta, an indication of ability to protect arteries

100.000 Damaged Aorta Area (μm2)

The effect of LipophytolTM microcapsules on aorta atherosclerotic lesions was examined on every group of mice after 8

TM

Atherosclerosis damage test indicated that

50.000

LipophytolTM microcapsules 0 Control

Phytosterols as Esters

Phytosterols as Lipophytol microcapsules TM

was the most effective in protecting mice arteries from the harmful effects of the high fat diet.

To enquire or request a sample, contact us at nutraceuticals@lubrizol.com The Lubrizol Corporation (“Lubrizol”) hopes that you have found the information provided helpful, but you are cautioned that this material, including any prototype formulas, is for informational purposes only and you are solely responsible for making your own assessment of appropriate use of the information.

TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAWS, LUBRIZOL MAKES NO REPRESENTATIONS, GUARANTEES, OR WARRANTIES (WHETHER EXPRESS, IMPLIED, STATUTORY, OR OTHERWISE), INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR REGARDING THE COMPLETENESS, ACCURACY, OR TIMELINESS OF ANY INFORMATION. Lubrizol does not guarantee how the materials referenced herein will perform in combination with other substances, in any methods, conditions, or processes, with any equipment, or in non-laboratory environments. BEFORE COMMERCIALIZATION OF ANY PRODUCT CONTAINING THESE MATERIALS, YOU SHOULD THOROUGHLY TEST SUCH PRODUCT, INCLUDING HOW THE PRODUCT IS PACKAGED, TO DETERMINE ITS PERFORMANCE, EFFICACY, AND SAFETY. You are solely responsible for the performance, efficacy, and safety of any products you manufacture. Lubrizol shall not be liable, and you shall assume all risk and responsibility for, any use or handling of any material. Any claims may not be approved in all jurisdictions. Any entity making claims related to these products is responsible for complying with local laws and regulations. Nothing contained herein is to be considered as permission, recommendation, or inducement to practice any patented invention without permission of the patent owner, and it is your sole responsibility to determine if any issues related to patent infringement of any component or combination of components relating to the information provided exists. You acknowledge and agree that you are using the information provided herein at your own risk. If you are dissatisfied with the information provided by Lubrizol, your exclusive remedy shall be to not use the information. LIPOTEC S.A.U., a subsidiary of Lubrizol. Isaac Peral 17 Pol. Industrial Camí Ral 08850 Gavà (Barcelona) Spain Tel +34 93 638 80 00 www.lubrizol.com

Ed. 25A © 2025 The Lubrizol Corporation or its affiliates.

MagshapeTM microcapsules is a highly concentrated and bioavai- lable source of magnesium source effective at restoring and maintaining a healthy level of magnesium in human cells and bones.

SCIENCE Magnesium is an essential mineral involved in energy metabolism, respiratory function and maintenance of normal muscle contraction and relaxation. Magnesium deficiency may lead to the distortion of neuromuscular function, suggesting a possible

•Helps to relax and alleviates fatigue

association between magnesium and muscle cramps.

•Provides vitality and stress relief

However, despite magnesium’s critical role, maintaining its intake at

•Improves muscular function

an adequate level has been frequently overlooked, therefore

•Enhanced flowability and compressibility

magnesium supplementation has been widely recommended.

In this respect, MagshapeTM microcapsules can contribute to an appropriate muscular function and an adequate energy level

COMPOSITION: Magnesium Oxide, Modified Starch, Sunflower Lecithin

for better performance. Furthermore, given its high magnesium

PRODUCT FORMAT: White-off-white to cream powder granules

its health benefits. Additionally, MagshapeTM microcapsules as

ACTIVE CONTENT: 30-34% elemental Mg

available to tissues.

DISPERSIBILITY: Highly dispersible

content, more magnesium gets into the bloodstream to deliver contains magnesium oxide, it has more elemental magnesium,

An improved stability, flowability, compressibility and pleasant taste compared to other magnesium sources, is also achieved thanks to the microencapsulation technology applied in the product

Active Nutrition Tablets and capsules

Powders

Imagined for life. Enabled by Science.™

Characterization - Rheological parameters comparison

The following parameters of were compared to the unencapsulated magnesium oxide salt to demonstrate the significant improvement in the rheological properties of the microen- capsulated product.

microcapsules MagshapeTM

Angle of repose/100 (*)

outperforms unencapsulated magnesium oxide

1.2 1 0.8 0.6

Compressibility Index

Mass flowrate (g/s)

0.4 0.2 0

Its properties including pleasant taste, good flowability and compressibility, make

MagshapeTM microcapsules Tapped density (g/ml)

Bulk density (g/ml)

MagshapeTM

In vitro efficacy - Muscular function improvement

High performance conditions were simulated (continuous stimulation at different frequencies for a long time) followed by induction of ramps (cramps) to study the effect of MagshapeTM

Control

Arbritary Units (a.u.)

Magnesium Oxide Powder

25000 20000

microcapsules MagshapeTM

15000

improve muscular function thanks to its relaxation capacity

10000 5000 0 6

8

10

12

14

16

Time (s)

After treatment with

micro-

MagshapeTM microcapsules

leswere stimulated at 10 Hz for 10 s and the response of the muscles was determined.

Arbritary Units (a.u.)

capsules on muscle relaxation.

Both muscle tissue bioprinted samples, control and, MagshapeTM microcapsu-

an ideal magnesium source for nutraceutical products.

25000 20000 15000 10000 5000 0 6

8

10

12

14

16

the muscle relaxes more quickly, so it can maintain a frequency of 10 Hz (simulation of cramp) without entering tetanic contraction.

Time (s)

Comparative clinical study on absorption kinetics A randomized, double-blind, repeated crossover trial with 40 healthy adults involved four stages of single-day sampling at 7-day intervals, where blood samples were taken at 0, 1, 4, and 6 hours after fasting and consuming each of the four magnesium products.

microcapsules MagshapeTM

significantly increases magnesium levels within 1 hour and maintains elevated levels for at least 6 hours.

The study found that

MagshapeTM microcapsules significantly enhance magnesium absorption while reducing common gastric side effects compared to other magnesium sources.

To enquire or request a sample, contact us at nutraceuticals@lubrizol.com The Lubrizol Corporation (“Lubrizol”) hopes that you have found the information provided helpful, but you are cautioned that this material, including any prototype formulas, is for informational purposes only and you are solely responsible for making your own assessment of appropriate use of the information.

TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAWS, LUBRIZOL MAKES NO REPRESENTATIONS, GUARANTEES, OR WARRANTIES (WHETHER EXPRESS, IMPLIED, STATUTORY, OR OTHERWISE), INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR REGARDING THE COMPLETENESS, ACCURACY, OR TIMELINESS OF ANY INFORMATION. Lubrizol does not guarantee how the materials referenced herein will perform in combination with other substances, in any methods, conditions, or processes, with any equipment, or in non-laboratory environments. BEFORE COMMERCIALIZATION OF ANY PRODUCT CONTAINING THESE MATERIALS, YOU SHOULD THOROUGHLY TEST SUCH PRODUCT, INCLUDING HOW THE PRODUCT IS PACKAGED, TO DETERMINE ITS PERFORMANCE, EFFICACY, AND SAFETY. You are solely responsible for the performance, efficacy, and safety of any products you manufacture. Lubrizol shall not be liable, and you shall assume all risk and responsibility for, any use or handling of any material. Any claims may not be approved in all jurisdictions. Any entity making claims related to these products is responsible for complying with local laws and regulations. Nothing contained herein is to be considered as permission, recommendation, or inducement to practice any patented invention without permission of the patent owner, and it is your sole responsibility to determine if any issues related to patent infringement of any component or combination of components relating to the information provided exists. You acknowledge and agree that you are using the information provided herein at your own risk. If you are dissatisfied with the information provided by Lubrizol, your exclusive remedy shall be to not use the information. LIPOTEC S.A.U., a subsidiary of Lubrizol. Isaac Peral 17 Pol. Industrial Camí Ral 08850 Gavà (Barcelona) Spain Tel +34 93 638 80 00 www.lubrizol.com

Ed. 25A © 2025 The Lubrizol Corporation or its affiliates.

NewcaffTM microcapsules is a novel caffeine delivery system which has been designed to mask the bitter taste of caffeine and provide sustained release.

SCIENCE Caffeine is a methylxanthine alcaloid which is well-known for its properties in the central nervous system, its action as a metabolic stimulant, and a fatigue reducer. Caffeine, however, is quickly

•Clean non-bitter taste •Controlled release •High caffeine concentration •Cleaner formulas

absorbed and therefore its stimulating effect can be felt instantly after consumption leading to energy fluctuations. In addition, this compound has a bitter taste which compromises its addition into food systems.

One of the trends driving the sports nutrition market growth is the sustained energy claim. Following this trend, there is current-

COMPOSITION: Caffeine, Mono and diglycerides of fatty acids PRODUCT FORMAT: White to off-white or Off-white to light brown powder or granules ACTIVE CONTENT: 56-60% or 73.3-78.3% caffeine DISPERSIBILITY: Limited dispersibility

ly a need for caffeinated products which can continuously provide the desired benefits associated without the unwanted effects for a longer time.

This need can be met by NewcaffTM microcapsules whichisdesigned by using lipid hot-melt fluid bed microencapsulationtechnique to provide a controlled release of caffeine withtheadditional benefit of masking its objectionable bitter taste.

Energy and Endurance Tablets and capsules

Liquids

Powders

Imagined for life. Enabled by Science.™

Characterization TEST

SPECIFICATION

characteristics of Newcaff

Color

White tolightbrown

microcapsules.

Caffeine Content

60%, 75%

Morphology

and

physicochemical TM

The bitter taste of caffeine particles in

NewcaffTM microcapsules is masked

Scanning Electron Microscopy Scanning electron microscopy (SEM) observations show caffeine powdered particles with an angular shape and polyhedral appearance. On the other hand, microcapsules containing caffeine have a round shape with little granules adhered to its surface forming the lipid

Caffeine particles received an uniform and stable

wrapping via NewCaffTM microcapsules technology successfully masking the bitter taste of caffeine.

SEM image of -60NewCaff microcapsules

SEM image of caffeine

TM

insulating coating.

In vitrorelease profile Caffeine release from the NewcaffTM

100 -

NewcaffTM microcapsules is

90 -

observed

80 % Released caffeine

microcapsules was tested using a standard method following the Health Canada official method of determination of the disintegration time DO-25 by being submitted to digestion process.

For this purpose, the analysis was carried out simulating in vitro digestive conditions at physiological temperature (37oC) and at physiological stomach and intestine pH.

A sustained release of the caffeine from

70 60 -

NewCaff microcapsules

50 -

TM

40 30 20 10 00,5

1

2

3

4

5

showed a good retention and an improved in vitro sustained release profile when compared to unencapsulated caffeine.

Time (hours)

Raw caffeine

Newcaff microcapsules TM

To enquire or request a sample, contact us at nutraceuticals@lubrizol.com The Lubrizol Corporation (“Lubrizol”) hopes that you have found the information provided helpful, but you are cautioned that this material, including any prototype formulas, is for informational purposes only and you are solely responsible for making your own assessment of appropriate use of the information.

TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAWS, LUBRIZOL MAKES NO REPRESENTATIONS, GUARANTEES, OR WARRANTIES (WHETHER EXPRESS, IMPLIED, STATUTORY, OR OTHERWISE), INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR REGARDING THE COMPLETENESS, ACCURACY, OR TIMELINESS OF ANY INFORMATION. Lubrizol does not guarantee how the materials referenced herein will perform in combination with other substances, in any methods, conditions, or processes, with any equipment, or in non-laboratory environments. BEFORE COMMERCIALIZATION OF ANY PRODUCT CONTAINING THESE MATERIALS, YOU SHOULD THOROUGHLY TEST SUCH PRODUCT, INCLUDING HOW THE PRODUCT IS PACKAGED, TO DETERMINE ITS PERFORMANCE, EFFICACY, AND SAFETY. You are solely responsible for the performance, efficacy, and safety of any products you manufacture. Lubrizol shall not be liable, and you shall assume all risk and responsibility for, any use or handling of any material. Any claims may not be approved in all jurisdictions. Any entity making claims related to these products is responsible for complying with local laws and regulations. Nothing contained herein is to be considered as permission, recommendation, or inducement to practice any patented invention without permission of the patent owner, and it is your sole responsibility to determine if any issues related to patent infringement of any component or combination of components relating to the information provided exists. You acknowledge and agree that you are using the information provided herein at your own risk. If you are dissatisfied with the information provided by Lubrizol, your exclusive remedy shall be to not use the information. LIPOTEC S.A.U., a subsidiary of Lubrizol. Isaac Peral 17 Pol. Industrial Camí Ral 08850 Gavà (Barcelona) Spain Tel +34 93 638 80 00 www.lubrizol.com

Ed. 25A © 2025 The Lubrizol Corporation or its affiliates.

microcapsules Stable and tasteless source of zinc

ZincnovaTM microcapsules is a non-reactive form of zinc oxide that has been microencapsulated in a food grade fat carrier to prevent moisture uptake and to delay undesirable interactions with other components of food formulations, thus preserving its bioavailability.

SCIENCE Zinc is one of the most important trace minerals in human nutrition.

It is a structural component of more than 100 enzymes and is involved in numerous aspects of cellular metabolism, wound healing as well as in growth maintenance during childhood and adolescence.

•Controlled interactions with other components

It also plays a unique function in boosting immunity and proper

•No grainy texture

functioning of the smell and taste systems. It has also been shown

•Reduced metallic taste

to be effective in reducing the duration and severity of cold

•Effective release in the stomach

symptoms.

Zinc deficiency can be due to inadequate intake of the mineral or to problems with absorption especially in people with gastroin-

COMPOSITION: Glyceryl esters of fatty acids PRODUCT FORMAT: White to Off-white powder

testinal disorders.

Various foods including oysters, red meats and poultry as well as

ACTIVE CONTENT: 18-22% elemental zinc.

some cereals and vegetables contain zinc naturally; however the

DISPERSIBILITY: Not dispersible

bioavailability of zinc from these sources. Vegetarians are often at a

presence of high levels of phytate in cereals can compromise the high risk of zinc deficiency, thus the need to include zinc fortified cerals in their diets.

ZincnovaTM microcapsules comprises a novel encapsulated zinc oxide for an easy fortification of a wide range of food applications with this nutrient.

Immune Health Tablets and capsules

Liquids

Powders

Imagined for life. Enabled by Science.™

Characterization

microcapsules ZincnovaTM

doesnotprovide a grainy texture

Microcapsules structure determination

The morphology of fortifying agents may affect organoleptic properties of foods.

The microcapsule structure of ZincnovaTM microcapsules was determined by Scanning Electron Microscopy.

The small size and spherical geometry of

ZincnovaTM microcapsules

diminish the contact surface, minimizing the grainy texture in the mouth.

Assays

microcapsules ZincnovaTM

Taste stability

does not alter the taste

A panel of volunteers tasted a commercial milk fortified with 0.1 mg/ml ZincnovaTM microcapsules. The non-enriched milk was used as a control.

The taste of the milk with

ZincnovaTM microcapsules did not show any remarkable difference respect to the non-fortified one.

Color stability

Organoleptic stability (taste & color)

An orange juice was fortified with a concentration of 0.1 mg/ml as ZincnovaTM microcapsules or non-encapsulated zinc oxide. The same commercial juice was used as a control. The samples were homogenized and pasteurized and the changes in color were controlled by a colorimeter.

The color of the juice

containing ZincnovaTM microcapsules was similar to that of the commercial juice.

Release profile

Effective releaseinthe

In order to study the availability of zinc after the digestion of a food fortified

stomach with

100 90 % Release fo Zn (II)

80

a with ZincnovaTM microcapsules, released assay was performed following the “Determination of the disintegration time of tablets official method of Health Canada”.

70

Results showed that 75%

60

of zinc ZincnovaTM

50

microcapsules was released

40

from ZincnovaTM

30 20 10

A simulated GIT release test was conducted using 0.1 mg/ml with or without pepsin (digestive enzyme). The pH was adjusted to 1.2-1.5 to simulate the stomach conditions.

ZincnovaTM

microcapsules

0 50

0

100

t (min)

Acid medium with pepsin

Acid medium

microcapsules in the absence of pepsin while almost 100% of the mineral was released after 2 hours in the presence of pepsin.

To enquire or request a sample, contact us at nutraceuticals@lubrizol.com The Lubrizol Corporation (“Lubrizol”) hopes that you have found the information provided helpful, but you are cautioned that this material, including any prototype formulas, is for informational purposes only and you are solely responsible for making your own assessment of appropriate use of the information.

TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAWS, LUBRIZOL MAKES NO REPRESENTATIONS, GUARANTEES, OR WARRANTIES (WHETHER EXPRESS, IMPLIED, STATUTORY, OR OTHERWISE), INCLUDING ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR REGARDING THE COMPLETENESS, ACCURACY, OR TIMELINESS OF ANY INFORMATION. Lubrizol does not guarantee how the materials referenced herein will perform in combination with other substances, in any methods, conditions, or processes, with any equipment, or in non-laboratory environments. BEFORE COMMERCIALIZATION OF ANY PRODUCT CONTAINING THESE MATERIALS, YOU SHOULD THOROUGHLY TEST SUCH PRODUCT, INCLUDING HOW THE PRODUCT IS PACKAGED, TO DETERMINE ITS PERFORMANCE, EFFICACY, AND SAFETY. You are solely responsible for the performance, efficacy, and safety of any products you manufacture. Lubrizol shall not be liable, and you shall assume all risk and responsibility for, any use or handling of any material. Any claims may not be approved in all jurisdictions. Any entity making claims related to these products is responsible for complying with local laws and regulations. Nothing contained herein is to be considered as permission, recommendation, or inducement to practice any patented invention without permission of the patent owner, and it is your sole responsibility to determine if any issues related to patent infringement of any component or combination of components relating to the information provided exists. You acknowledge and agree that you are using the information provided herein at your own risk. If you are dissatisfied with the information provided by Lubrizol, your exclusive remedy shall be to not use the information. LIPOTEC S.A.U., a subsidiary of Lubrizol. Isaac Peral 17 Pol. Industrial Camí Ral 08850 Gavà (Barcelona) Spain Tel +34 93 638 80 00 www.lubrizol.com

Ed. 25A © 2025 The Lubrizol Corporation or its affiliates.

Contact us for more information: We are ready to assist you and support your projects.

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Ernesto Camarena DS, NU & CC Manager | CPQ ernesto.camarena@grupocpq.com +52 33 1011 5070

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Ed. 25A © 2025 The Lubrizol Corporation or its affiliates.