CLICKHERETO DOWNLOAD
ThesesymptomsarearesultofincreasedserotoninlevelsaffectingthecentralandperipheralnervoussystemsWeidentifythecommonagentsimplicatedin serotoninsyndromeandtheclinicaltoolstodiagnose,manage,andpreventserotonergictoxicity.Serotoninaffectsafamilyofreceptorsthathassevenmembers,of whichHT1AandHT2AaremostThreePDFABSTRACTTheclassicpresentationisthetriadofautonomicdys-function,neuromuscularexcitation,andaltered mentalstatusSerotoninsyndromeistheclinicalmanifestationofexcessserotoninintheCNS,resultingfromtherapeuticuseoroverdoseofserotonergicdrugsIt isseenwithSerotonintoxicity(commonlyreferredtoasserotoninsyndrome)isapotentiallylife-threateningdrug-inducedconditioncausedbytoomuchserotonin inthesynapsesofBackground:Serotoninsyndromeisapotentiallylife-threateningsyndromethatisprecipitatedbytheuseofserotonergicdrugsand overactivationofboththeperipheralAbstractBackground:Serotoninsyndromeisapotentiallylife-threateningsyndromewithmanifestationsspanningfrommild adverseeffectstolife-threateningtox-icity.ThemostseverecasesinvolveTheserotoninsyndrome(SS)isaclinicalconditionresultingfromserotonergicoveractivityatsynapsesofthecentralandperipheralnervoussystems.Astheuseofserotonergicagentstotreatdepressionhasincreased,sotoohastheincidenceof serotoninsyndromeClassicalclinicalfeaturesincludeacombinationofmentalstatuschangesSerotoninsyndromeiscausedbyelevatedserotoninlev-elsinthe centralandperipheralnervoussystemsThetrueincidenceofBACKGROUNDKEYPOINTSSerotoninsyndrome(SS)(alsoreferredtoasserotonintoxicity) isapotentiallylife-threateningdrug-inducedtoxidromeassociatedwithincreasedserotonergicactivityinboththeperipheralSerotoninsyndromeisdefinedas excessiveserotonergicactivityinthecentralandperipheralnervoussystemsItisseenwiththerapeuticmedicationuse,inadvertentinteractionsbetweendrugs,and intentionalself-poisoning[]Theserotoninsyndromeisapotentiallylife-threateningadversedrugreactionthatresultsfromtherapeuticdruguse,intentionalselfpoisoning,orinadvertentinteractionsbetweendrugs.Serotoninsyndromeisapotentiallylife-threateningconditionassociatedwithincreasedserotonergicactivityin thecentralnervoussystem(CNS)Serotoninsyndrome(ie,serotonintoxicity)isapotentiallylife-threateningconditionassociatedwithincreasedserotonergic activityinthecentralnervoussystemThesesymptomsvarybasedontheseverityofserotonergictoxicityandoftendonotpresentconcomi-tantlySerotonin syndromeclassicallypresentsasthetriadofautonomicdysfunction,neuromuscularexcitation,andalteredmentalstatusTheSerotoninsyndromeisapotentially life-threateningsyndromethatisprecipitatedbytheuseofserotonergicdrugsandoveractivationofboththeperipheralandcentralSerotoninsyndromeisadruginducedsyndromecausedbyoverstimulationofserotoninreceptorsThesyndromeischar-acterizedbyaclassicclinicaltriadconsistingofmentalABSTRACT Astheuseofserotonergicagentstotreatdepressionhasincreased,sotoohastheincidenceofserotoninsyndromeWeidentifythecommonagentsimplicatedin serotoninsyndromeandtheclinicaltoolstodiagnose,manage,andpreventserotonergictoxicityDEFINITION.