The Faculty of Science, Technology and Medicine (FSTM) at the University of Luxembourg presents its main achievements in 2019-2020. The creation of new training programmes, the recruitment of talented people, the acquisition of renowned grants and the development of outreach activities were at the top of the agenda. Of course, the Covid-19 health crisis had a considerable impact on the teaching and research activities, but which, in the end, revealed the ability to adapt and innovate.