Innovative Tripeptide

SYNEPIN & SYNDERMIN

Palmitoyl sh-Tripeptide-3 Amide, Palmitoyl sh-Tripeptide-1 Amide

1-4

Water-soluble

Epidermal Growth Factor tripeptide

Synepin - EGF tripeptide binds to a speci c site of EGF receptor in epidermis. The EGF receptors of epidermal cells signal to proliferate the epidermal cells (keratinocytes) and broblasts in speci c target areas. In this way, Synepin functions as a booster of the cellular turnover by promoting the growth of keratinocytes and dermal broblasts.

ADIPONIN

Adiponectin receptor agonistic tripeptide

Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine. In humans it is encoded by the ADIPOQ gene and it is produced in primarily in adipose tissue, but also in muscle, and even in the brain. Adiponectin stimulates fatty acid oxidation in skeletal muscle and inhibits glucose production in the liver, resulting in an improvement in whole-body energy homeosta sis. Adiponectin is also a classic anti-in amma tory agent, reducing in ammation in various cell types through AdipoR1 and R2 signaling mechanisms.

Adiponectin tripeptide helps to proliferate epidermal cells and produce ceramides, collagen and hyaluronic acids within dermis as well as works as an anti-in ammatory factor.

Fibroblast Growth Factor tripeptide

Syndermin - FGF tripeptides, when topically applied, can penetrate dermis, interact with FGF receptors and role as a boost of cellular turnover of keratinocytes and dermal broblasts as well as enhance collagen and elastic synthesis.

Acetyl Tripeptide-54 Amide

1-5 %

Water-soluble

BINTERIN

Palmitoyl sh-Tripeptide-4 Amide

2-4 %

Water-soluble

Anti-in ammation & soothing: Suppressing the expression and the activation of pro-in ammatory cytokines (TNF-a, IL-1b). CD99-peptide was con rmed to suppress not only in ammatory reaction in an acute contact dermatitis in a dose-depen dent manner, but also suppress collagen-induced arthritis and UVB induced collagen ber breakdown. Binterin alsohelps relieve acne by modulating in ammatory reactions and regulating secretion of sebum.

RELATED PAPER

CD99-Derived Agonist Ligands Inhibit Fibronectin-in duced Activation of 1 Integrin through the Protein Kinase A/SHP2/Extracellular Signal-regulated Kinase/PTPN12/Focal Adhesion Kinase signaling pathway (2017, Molecular and Cellular Biology)

Topically excellent for skin soothing, anti-in ammation, redness reduction: equals to dexamethasone (DXS) in anti-in ammation level. Soothing serum, masks, post laser/micro-needling/micro dermabrasion/tattoo removal, topical analgesic, before/after sports activities etc.

CD-99 derived anti-inflammation & soothing tripeptide

WINHIBIN

SFRP5-Win signaling inhibitor tripeptide

Palmitoyl Tripeptide-53 Amide

1-5 %

Water-soluble

SFRPs, an antagonist that directly binds to Wnt. SFRP5 inhibits melanin synthesis of melanocytes by suppress ing the signaling pathways of the Wnt/β-catenin and the next microphthalmia-associated transcription factor (MITF) and its target proteins.

Wihibin is topically excellent for skin rejuvenation like anti-melanogenesis, anti-photoaging, skin whitening, soothing, vitiligo etc.

Secreted Frizzled-related Protein 5 (SFRP5) tripeptide (Winhibin) blocks Wnt signaling

TESTIMONIAL

Skin

Effect

Effect

ENFIBIN

NFkB inhibition tripeptide

Acetyl Tripeptide-74 Amide 1-5%

Water-soluble

NF-κB (or NF-kappaB, "nuclear factor kappa-light-chain-enhancer of activated B cells") is a protein complex that controls transcrip tion of DNA, cytokin e production and cell survival.

NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals (ROS, reactive oxygen species, Oxidative Stress, heavy metals, (UV) ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens.

Topically excellent for skin soothing, anti-in ammation, anti-pho toaging etc.

Effect of Enfibin™

Air Pollution