Peripheral Artery Disease In peripheral artery disease, there is a reduction in blood flow to the Limbs because the arteries get narrowed. It is a common circulatory problem. When a person is suffering from PAD, their legs will not be able to receive enough blood according to the demand. This results in constant pain in the legs during walking. Additionally, peripheral artery disease also contributes to the sign of accumulation of fatty deposits in the arteries. This is the condition where the blood flow gets reduced to the heart and brain and legs as well. If one wants to get rid of peripheral artery disease, they need to quit tobacco and have a healthy diet and regular exercise.