PhoneLab AI Booklet

PhoneLab AI Democratizing Health On a Global Scale

__________________________________________________________________________ Sivad | PhoneLab AI | Democratizing Health On a Global Scale (1)

PhoneLab AI™ Solution Overview Focus on Sickle Cell Disease

Disruptive Technology PhoneLab AI is a truly disruptive technology ─ a synergy of advanced cloud technology + artificial intelligence + state-ofthe-art rapid diagnostics.

The value and benefits of PhoneLab AI are limited only by one’s imagination.

Imagine a highly affordable solution that provides:  Rapid diagnostics across multiple categories including Sickle Cell Disease, infections disease, women’s health, cardiovascular health, oncology, substances of abuse, and many more  Highly accurate AI-based interpretation of test results via a standard mobile phone’s camera

A fully customizable Insights Center that converts complex data into highly actionable insights  The ability, based on roles and responsibilities, to deliver data either anonymized or with full personally identifiable information (PPI).  The ability to deliver the data in customized forms to disparate stakeholders  The ability, via secure file transfer protocol (sFTP) or advanced application programming interfaces (API), to deliver data to any organization or government entity in real-time  The ability to store the test image for further interpretation by a healthcare professional, if required  The ability to perform correlative and retrospective analysis on any data

 Automatic real-time, data capture triggered by the phone’s camera  Cloud-based data processing, management and storage via the highly robust and secure Amazon Web Services (AWS) global infrastructure. __________________________________________________________________________ Sivad | PhoneLab AI | Democratizing Health On a Global Scale (2)

Democratizing Healthcare The quality of healthcare exists on a gradient from superior to inferior based on many factors.

PhoneLab AI is a major step in healthcare democratization. Finally, a patient tested in a church in a remote area will receive the same diagnostics and treatment as a resident of a gated community in Abuja.

camera.  In real-time, the phone displays the results as positive, negative, Sickle Cell Disease or

carrier, etc.  At the same time, without any user intervention, the data accompanied by the actual picture of the test device, is sent to the secure AWS cloud.  In real-time, the remote Insights Center is updated with the new data.

PhoneLab AI – Schematic  Phone Lab AI is trained on each rapid diagnostic (indicated by the dashed line rectangle)  The tester simply performs the rapid test and, after a predetermined period of time (typically between 5 and 15 minutes), snaps a picture of the test with a mobile phone’s

 If a healthcare professional wishes to view the results either locally or at a remote location anywhere in the world, the data accompanied by the actual image of the test results are immediately available.  In addition, the data can be seamlessly interfaced with any government department, hospital (public or private), NGO, or other entity.

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____________________________________________ Focus on Sickle Cell

PhoneLab AI is highly effective for both diagnostic and treatment as well as genetic counselling.

Knowing the probability of having a child with full Sickle Cell Disease is a major component of genetic counselling.

Since carriers (trait) are typically asymptomatic, testing is a vital component of effective counselling. __________________________________________________________________________ Sivad | PhoneLab AI | Democratizing Health On a Global Scale (4)

The Phone Lab AI Sickle Cell Test is actually 5 tests in 1 It detects:

 Normal  Sickle Cell S carrier  Sickle Cell SS Disease  Sickle Cell C carrier  Sickle Cell SC disease A single sample is all it takes to achieve comprehensive results.

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Selected Uses  Make Critical Decisions

Nothing speaks louder and is more compelling than accurate, real-time data.

 Perform Informed Genetic Counselling

Guide couples through a conscientious and balanced decision-making process

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 Drug and Vaccine Allocation

Use real time aggregate data to determine the exact quantity of drugs and vaccines to be distributed to each Nigerian region – prevent shortages and eliminate waste.

To ensure compliance with the correct use of PhoneLab AI, develop a public policy that drugs and vaccines will only be distributed based on real, accurate testing data.

An added benefit is the just-in-time inventory (JIT) feature, which provides actual test consumption data that can be used to re-stock a region with new tests.

In Nigeria, 50%-90% of children born with sickle cell disease die before the age of 5 years • Approximately 150,000 babies are born annually with sickle SCD • Projected to increase by 100% by the year 2050 to 300,000 • A nation-wide, low-cost newborn screening for SCD is not implemented yet • Screening will facilitate  Genetic counseling  Education of parents/guardians  Comprehensive disease management

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Critical Insights  Evaluate your Antibiotic/Vaccine/Drug programs’ effectiveness

An effective program will result in a significant reduction in infant mortality  Evaluate the effectiveness of genetic counseling programs

An effective program will result in a significant reduction in new births with SCD

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 Demonstrate the effectiveness of grants and other funds and win more

An effective, objectively evaluated program using actual data will result in a significant increase in funding  Distribute accurate data in real-time to the entire Nigerian Ecosystem

The value of real time data is almost immeasurable. It can be used for analytics, retrospective studies, clinical purposes, funding, and so much more

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Data and Process Flow

Real Time Data Via the Insights Center, view live data from throughout Nigeria Seamlessly switch from one analyte to another

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Clinical Profile View the current and historic clinical profile of each patient including an image of each test

Sickle SCAN Data Sickle SCAN® has both a combined sensitivity and specificity of >99% and provides results in 5 minutes, making it one of the fastest and most accurate tests in the world.

Performance data was derived from trials using high-performance liquid chromatography (HPLC) as the gold standard.

Pivotal Study: Preliminary Evaluation of a Point-of-Care Testing Device (Sickle SCAN™ in Screening for Sickle Cell Disease Hemoglobin international journal for hemoglobin research, March 28, 2017 Trial conducted by The Center of Excellence for Sickle Cell Disease Research & Training, University of Abuja Full Trial data is available upon request.

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Additional Information Partial portfolio of ready-to-deploy tests (pre-AI trained) Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Disease Infectious Disease Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health

Malaria Pf / Ag Malaria Pf & Pv / Ag Malaria Pf & Pan / Ag Malaria Pf & Pv / Ab Dengue IgG & IgM /Ab Dengue NS1 (Ag) TB Ab IgG Test HIV 1/2 (Ab) HBsAg One Step Ultra Hepatitis B Surface Antigen Test HCV One Step Hepatitis C Virus Test Hepatitis B s Antigen Test Hepatitis B s Antibody Test Hepatitis B e Antigen Test Hepatitis B e Antibody Test Hepatitis B c Antibody Test HBe AG Test HBs AG Test HBc Ab Test HCV Test HEV Ab IgM Test SARS CoV-2 Antigen Test (Nasal Swab) SARS CoV-2 IgG/IgM Antibody Test Chikungunya IgM Chikungunya IgM / IgG (Ab) Leishmania (Kalaazar) Zika Virus IgG/IgM Ab Test Anti- Tuberculosis test (H.P) Helicobacter pylori antibody test (MP) Mycoplasma Pneumoniae IgM Test Chlamydia Pneumonia IgM Antibody Test Kit (Colloidal Gold) Mycoplasma Pneumonia IgM Antibody Test Kit (Colloidal Gold) Treponema Pallidum Antibody Test Kit (Colloidal Gold) Dengue NS1 antigen and IgG/antibodies in human serum/plasma Dengue IgA/IgM/IgA Antibody & NS1 Antigen (Fourplex) Dengue IgG/IgM Ab – NS1 Ag, Chikungunya IgG/IgM/Ab & Zika IgG/IgM Ab Test Multi-panel test Dengue NS1/Dengue IgG & IgM/Malaria Ab） Influenza A & B Antigen Test Dengue IgG/IgM/IgA (triplex) Dengue IgG/IgM /NS1 (Ag) Dengue IgG/IgM/IgA (Ab) /NS1 (Ag) HIV 1/2 (Ab) & P24 ag (4th generation) HIV/HCV/HBS Ag combo (Triblex) Typhoid COVID-19 Luteinizing Hormone HCG Ultrasensitive Early Detection HCG Ultrasensitive Early Detection Herpes Simplex Virus I IgG/IgM (Ab) Herpes Simplex Virus 2 IgG/IgM (Ab) Toxoplasma gondi IgG/IgM (Ab) Rubella Virus IgG/IgM (Ab)

Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Combo Test Combo Test Combo Test Combo Test Combo Test Combo Test Combo Test Combo Test Combo Test Combo Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test

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Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health Drugs Abuse Drugs Abuse Drugs Abuse Drugs Abuse Drugs Abuse Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Infectious Diseases Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health Women's Health Drugs Abuse

Cytomegalovirus IgG/IgM (Ab) Torch IgG/IgM Panel (Toxo, HSV 1,2, CMV & RUB)) Iron Deficiency FSH Chlamydia Antigen Treponema Pallidum (Syphilis) Amphetamine (AMP) Barbiturates (BAR) Benzodiazepine (BZO) Cocaine (COC) Benzoylecgonine (B-COC) (Cocaine) Mycoplasma Pneumonia IgM Antibody Test Kit (Colloidal Gold) Treponema Pallidum Antibody Test Kit (Colloidal Gold) Dengue NS1 antigen and IgG/antibodies in human serum/plasma Dengue IgA/IgM/IgA Antibody & NS1 Antigen (Fourplex) Dengue IgG/IgM Ab – NS1 Ag, Chikungunya IgG/IgM/Ab & Zika IgG/IgM Ab Test Multi-panel test Dengue NS1/Dengue IgG & IgM/Malaria Ab） Influenza A & B Antigen Test Dengue IgG/IgM/IgA (triplex) Dengue IgG/IgM /NS1 (Ag) Dengue IgG/IgM/IgA (Ab) /NS1 (Ag) HIV 1/2 (Ab) & P24 ag (4th generation) HIV/HCV/HBS Ag combo (Triblex) Luteinizing Hormone HCG Ultrasensitive Early Detection HCG Ultrasensitive Early Detection Herpes Simplex Virus I IgG/IgM (Ab) Herpes Simplex Virus 2 IgG/IgM (Ab) Toxoplasma gondi IgG/IgM (Ab) Rubella Virus IgG/IgM (Ab) Cytomegalovirus IgG/IgM (Ab) Torch IgG/IgM Panel (Toxo, HSV 1,2, CMV & RUB)) Iron Deficiency FSH Chlamydia Antigen Treponema Pallidum (Syphilis) Multiple

Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Combo Test Combo Test Combo Test Combo Test Combo Test Combo Test Combo Test Combo Test Combo Test Combo Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test Single Test

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Training We offer both remote and in-person training.

We prefer the train-the-trainer model, which provides competency continuity over time.

We recommend synchronous training at the program’s inception and asynchronous training thereafter.

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Important Features

Partial Certifications

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Costs CIF Lagos* PhoneLab AI tests range in price from USD $2.50 to USD $4.50 based on the following factors: 

Type of test



Annual quantity of each test



Frequency and size of each order

All test costs include the entire cloud-based technology solution and perpetual data storage. * One-time program development cost will be quoted based on actual requirements

Extra Value-Added Services 

Custom programming



Custom training programs

It Takes A Village In addition to Sivad’s responsibilities, the following functions need to be provided by parties in Nigeria: 

Access to key stakeholders for requirements gathering and ongoing feedback



Possible changes to public policy



Identification of roles and responsibilities of: o The Tribe Warrior Sickle Cell Foundation o Government employees o Others

 Pull-through awareness It is imperative that the Program and its vital functions are communicated clearly and effectively to all states and their respective residents  Ongoing feedback Critical feedback should be provided whenever an issue or opportunity presents itself.

In addition, quarterly program assessment meeting with all principal and other stakeholders should be conducted either in person or virtually __________________________________________________________________________ Sivad | PhoneLab AI | Democratizing Health On a Global Scale (16)

Cost Comparison with HPLC in Nigeria Diagnostic

Acronym

Cost

High-Performance Liquid Chromatography*

HPLC

USD $40.00

LF

USD $4.00

Rapid Lateral Flow**

*

Requires (i) expensive equipment and extensive training, (ii) travel to remote lab, or (3) transport of sample to remote lab ̶ not appropriate for point-ofcare use

** Includes nation-wide, cloud-based Disease Management Solution

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PhoneLab AI

The Future is Now!

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