Insight Spring 2023

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Spring 2023

Research and Scholarship

Welcome to the spring 2023 issue of Insight, a newsletter celebrating the accomplishments of our community of scholars. We aim to spotlight insights from people at the Dugoni School working in all areas of scholarship, including clinical or biomedical research, the scholarship of teaching and learning, improvement of the health care system, and professional partnerships that advance the field.

Save the Date for OKU-Sutro Excellence Day!

May 3, 2023 | 1:00 pm- 5:00 pm

1:00 – 2:00 pm | Keynote Presentation — TBD 2:15 – 5:00 pm | Student Presentations/Judging Sessions

Join us as a presenter — or step up and be a judge! Judges will review presentations and posters in dental and basic research, clinical cases, and community health showcase projects prepared by dental students, residents, faculty, and staff.

Explore the gallery of past OKU Sutro Excellence Day work at All alumni and faculty are invited to become judges. Please email the event team at to sign up.

Grant Activity at the Dugoni School

Congratulations to all Dugoni School faculty who are currently receiving grants, or who participated last year in submissions of external grant applications exceeding $200,000 in total direct funding. We would like to acknowledge all principal investigators and their co-principal investigators (collaborators) who have made the projects possible.

Below is a list of awardees or applicants and the funding agency for each:

• Hee-soo Oh (National Institutes of Health)

• Jonas Bianchi (National Institutes of Health)

• David Lam (National Institutes of Health, Department of Defense, and Stanford Head and Neck Cancer SPORE)

• Robert Trezia (San Francisco Department of Health)

Research and Scholarshipinsight

• William Sands (Appropriations from Senator Padilla, and from Senator Feinstein)

• Rebecca Moazzez (National Institutes of Health)

• Elisa Chavez (Health Resources & Services Administration, and Department of Health Care Access and Information)

• Andrew Young (National Institutes of Health)

• Darren Cox (Stanford Head and Neck Cancer SPORE)

• David Ojcius (National Institutes of Health, and Department of Defense)

• Tori Xiao (Tobacco Related Disease Research Program)

• Kim Benton (Department of Health Care Access and Information)

• Xiaoyuan Han (National Institutes of Health)

• Des Gallagher (San Francisco Department of Health)

• Nejat Duzgunes (National Institutes of Health)

• Cassio Silva (Tobacco Related Disease Research Program, and National Institutes of Health)

• Tamer Alpagot (Tobacco Related Disease Research Program)

Research in the Spotlight

Three-dimensional digital applications for implant space planning in orthodontics

What is it?

An overview of 3D imaging tools for implant treatment planning.

What problem does it aim to solve?

Implant failure rates are as high as 20%; good visualization is essential for planning before surgery. “Before, only two-dimensional examinations such as panoramic images were available to clinicians, limiting the capacity of the evaluation to only vertical and horizontal dimensions of the space while evaluating the edentulous area and planning implants.”

How does it work?

Combining multisource images such as Cone-Beam Computed Tomography (CBCT) and 3D digital dental models is essential for proper planning and managing implant surgery combined with orthodontic treatment. In addition, the use of data science approaches, advances in the image analysis field, and new AI approaches are becoming more popular among clinicians because of translational research and software availability. Therefore, better and more personalized treatment can be available, helping the clinical decision making and the prognosis.”

What are the real-world implications?

“The orthodontist needs to analyze each patient individually and use different software or tools that better fit their practice, allowing efficient treatment planning and satisfactory results with an adequate prognosis.”

What are the next steps?

While clinicians can benefit from these tools today, ongoing research alongside the ongoing development of and feature enhancements to these tools will help inform best practices.


“Three-dimensional digital applications for implant space planning in orthodontics: A narrative review”, Journal of the World Federation of Orthodontists 11 (2022) 207–215



and Scholarship


Jonas Bianchi, Arthur A. Dugoni School of Dentistry

Gustavo Mendonca, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan

Maxime Gillot, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, Michigan

Heesoo Oh, Arthur A. Dugoni School of Dentistry

Joorok Park, Arthur A. Dugoni School of Dentistry

Najla Al Turkestani, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, Michigan; Department of Restorative and Aesthetic Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia

Marcela Gurgel, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, Michigan

Lucia Cevidanes, Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, Michigan

Implant components were planned into the 3shape implant studio. Design of the implant based on the anatomy of the bone and dentition.

Research and Scholarshipinsight

Refined Topical 5-Fluorouracil Technique for the Targeted Treatment of Odontogenic Keratocysts

Representative example of odontogenic keratocyst treated with refined topical 5-fluorouracil technique. A, Preoperative Panorex radiograph showing a biopsy-confirmed odontogenic keratocyst involving the right mandibular body, and ramus. B, Six-month postoperative Panorex radiograph showing a well-healed, cystfree right mandible treated with enucleation, peripheral ostectomy, and refined topical 5fluorouracil technique.

What is it?

Odontogenic keratocysts (OKCs) are benign but often aggressive lesions in the jaw. This study represents an investigation of a potentially better way to treat them.

What problem does it aim to solve?

Treatment for OKCs includes application of a drug called 5-fluorouracil (5-FU), which is effective, but the way it is administered, using gauze packing material, is often very uncomfortable/painful for patients, and the gauze may be hard to place correctly if the lesion is too small or in a difficult-to-access location.

How does it work?

Thirteen patients were treated with this new method, in which the surgical cavity was irrigated with saline then covered with topical 5% 5-FU using a cotton swab. The final step was to place absorbable gelatin sponge coated with 5% 5-FU. “This refined technique further increases technical ease, decreases operative time, and precludes the need for packing removal, with similar efficacy as the original approach.


Research and Scholarship

What are the real-world implications?

If results hold up in subsequent studies over time, this method could be a better way of treating OKCs without having to remove packed gauze.

What are the next steps?

“A well-designed, long-term, prospective, randomized, double-blinded, controlled clinical trial would further support the above findings. A prospective study is currently underway.”


“Refined Topical 5-Fluorouracil Technique for the Targeted Treatment of Odontogenic Keratocysts,”Journal of Oral and Maxillofacial Surgery, Volume 81, Issue 1, January 2023, Pages 95-100,


Anthony J. Casino DDS, Clinical Associate Professor, Department of Oral & Maxillofacial Surgery, Stony Brook School of Dental Medicine, Stony Brook, NY

James LeRoy Jr. DMD, Chief Resident, Department of Oral & Maxillofacial Surgery, Stony Brook School of Dental Medicine, Stony Brook, NY

Rekha Reddy DMD, Clinical Assistant Professor, Department of Oral & Maxillofacial Surgery, Stony Brook School of Dental Medicine, Stony Brook, NY

David K.Lam MD, DDS, PhD, Professor & Chair, Department of Oral & Maxillofacial Surgery, Dr. T. Galt and Lee

DeHaven Atwood Endowed Professor in Oral and Maxillofacial Surgery, Associate Dean for Medical Integration, University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco, CA

Recent Publications

Congratulations to Dugoni School faculty, staff, student and resident researchers involved in the following research publications in the last few months.

Richards, G.D., Jabbour, R.S., Guipert, G., Defleur, A.

Endocranial anatomy of the Guercy 1 early Neanderthal from Baume Moula-Guercy (Soyons, Ardèche, France)

(2023) Anatomical Record, 306 (3), pp. 564-593.

View › | DOI: 10.1002/ar.25118

Elbarbary, M., Goldberg, M., Tenenbaum, H.C., Lam, D.K., Freeman, B.V., Pustaka, D.J., Mock, D., Beyene, J., Azarpazhooh, A.

Assessment of Concordance between Chairside Ultrasonography and Digital Palpation in Detecting Myofascial Trigger Points in Masticatory Myofascial Pain Syndrome

(2023) Journal of Endodontics, 49 (2), pp. 129-136.

View › | DOI: 10.1016/j.joen.2022.11.013

Yoon, A., Kim, T.K., Abdelwahab, M., Nguyen, M., Suh, H.Y., Park, J., Oh, H., Pirelli, P., Liu, S.Y.-C. What changes in maxillary morphology from distraction osteogenesis maxillary expansion (DOME) correlate with subjective and objective OSA measures?

(2023) Sleep and Breathing, .

View › | DOI: 10.1007/s11325-022-02761-5


Research and Scholarship

Einhaus, J., Han, X., Feyaerts, D., Sunwoo, J., Gaudilliere, B., Ahmad, S.H., Aghaeepour, N., Bruckman, K., Ojcius, D., Schürch, C.M., Gaudilliere, D.K. Towards multiomic analysis of oral mucosal pathologies

(2023) Seminars in Immunopathology, .

View › | DOI: 10.1007/s00281-022-00982-0

Martel, J., Chang, S.-H., Chevalier, G., Ojcius, D.M., Young, J.D. Influence of electromagnetic fields on the circadian rhythm: Implications for human health and disease

(2023) Biomedical Journal.

View › | DOI: 10.1016/

Chen, L.-C., Chen, Y.-J., Lin, H.-A., Chien, W.-C., Tsai, K.-J., Chung, C.-H., Wang, J.-Y., Chen, C.-C., Liao, N.-S., Shih, C.-T., Lin, Y.-Y., Huang, C.-N., Ojcius, D.M., Huang, K.-Y., Lin, H.-C.

Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming (2023) Immunology.

View › | DOI: 10.1111/imm.13628

Fears, N.E., Sherrod, G.M., Templin, T.N., Bugnariu, N.L., Patterson, R.M., Miller, H.L.

Community-based postural control assessment in autistic individuals indicates a similar but delayed trajectory compared to neurotypical individuals

(2023) Autism Research.

View › | DOI: 10.1002/aur.2889

Casino, A.J., LeRoy, J., Jr., Reddy, R., Lam, D.K.

Refined Topical 5-Fluorouracil Technique for the Targeted Treatment of Odontogenic Keratocysts

(2023) Journal of Oral and Maxillofacial Surgery, 81 (1), pp. 95-100.

View › | DOI: 10.1016/j.joms.2022.09.010

Chambers, D.W.

Dental hygiene students’ participation as subjects in a randomized controlled trial: A full evidence-based dentistry experience

(2023) Journal of Dental Education, 87 (1), pp. 34-42.

View › | DOI: 10.1002/jdd.13097

Saghiri, M.A., Saghiri, A.M., Samadi, E., Nath, D., Vakhnovetsky, J., Morgano, S.M. Neural network approach to evaluate the physical properties of dentin (2023) Odontology, 111 (1), pp. 68-77.

View › | DOI: 10.1007/s10266-022-00726-4

Quilici, G., Tolarova, M.M., Quilici, M., Quilici, D.L. Dental treatment of patients with prune belly syndrome (2023) Special Care in Dentistry, 43 (1), pp. 67-72.

View › | DOI: 10.1111/scd.12728

Marić, I., Contrepois, K., Moufarrej, M.N., Stelzer, I.A., Feyaerts, D., Han, X., Tang, A., Stanley, N., Wong, R.J., Traber, G.M., Ellenberger, M., Chang, A.L., Fallahzadeh, R., Nassar, H., Becker, M., Xenochristou, M., Espinosa, C., De Francesco, D., Ghaemi, M.S., Costello, E.K., Culos, A., Ling, X.B., Sylvester, K.G., Darmstadt, G.L., Winn, V.D., Shaw, G.M., Relman, D.A., Quake, S.R., Angst, M.S., Snyder, M.P., Stevenson, D.K., Gaudilliere, B., Aghaeepour, N.

Early prediction and longitudinal modeling of preeclampsia from multiomics (2022) Patterns, 3 (12), art. no. 100655.

View › | DOI: 10.1016/j.patter.2022.100655


Research and Scholarship

Bianchi, J., Mendonca, G., Gillot, M., Oh, H., Park, J., Turkestani, N.A., Gurgel, M., Cevidanes, L. Three-dimensional digital applications for implant space planning in orthodontics: A narrative review

(2022) Journal of the World Federation of Orthodontists, 11 (6), pp. 207-215.

View › | DOI: 10.1016/j.ejwf.2022.10.006

Hachem, C.E., Chedid, J.C.A., Nehme, W., Kaloustian, M.K., Ghosn, N., Sahnouni, H., Mancino, D., Haikel, Y., Kharouf, N.

Physicochemical and Antibacterial Properties of Conventional and Two Premixed Root Canal Filling Materials in Primary Teeth

(2022) Journal of Functional Biomaterials, 13 (4), art. no. 177.

View › | DOI: 10.3390/jfb13040177

Zheng, M., O’Brien, K., Cuenin, K., Lyon, C., Bender, D.

Impact of test-enhanced learning as a study strategy: An exploratory study with first-year dental students

(2022) Journal of Dental Education, 86 (12), pp. 1611-1619.

View › | DOI: 10.1002/jdd.13066

Radif, M.S., Han, A.N., Fa, B.A.

Oral anesthesia manikin training reduces student anxiety and builds local anesthesia delivery skills: A pilot study

(2022) Journal of Dental Education, 86 (S3), pp. 1737-1738.

View › | DOI: 10.1002/jdd.12904

Han, A.N., Laughter, L., Iyer, P., Radif, M.S.

A competency-based online curriculum mapping process for dental and dental hygiene education

(2022) Journal of Dental Education, 86 (S3), pp. 1693-1695.

View › | DOI: 10.1002/jdd.12879

Alzoubi, F.M., Sabti, M., Alsarraf, E., Alshahrani, F.A., Sadowsky, S.J. Preload evaluation of 2 implant-supported fixed partial denture abutment designs

(2022) Journal of Prosthetic Dentistry, 128 (5), pp. 1067.e1-1067.e6.

View › | DOI: 10.1016/j.prosdent.2022.09.002

Hatcher, D.C.

Anatomy of the Mandible, Temporomandibular Joint, and Dentition

(2022) Neuroimaging Clinics of North America, 32 (4), pp. 749-761.

View › | DOI: 10.1016/j.nic.2022.07.009

Itaya, L.E., Heydari, A., Sands, W.C., Okamura, M.Y., Creasey, J., Wong, A. Virtual Interview Day: An AEGD’s approach and assessment of interviewing during a pandemic (2022) Journal of Dental Education, 86 (11), pp. 1439-1447.

View › | DOI: 10.1002/jdd.13024

Islam, N.M., Laughter, L., Sadid-Zadeh, R., Smith, C., Dolan, T.A., Crain, G., Squarize, C.H. Adopting artificial intelligence in dental education: A model for academic leadership and innovation

(2022) Journal of Dental Education, 86 (11), pp. 1545-1551.

View › | DOI: 10.1002/jdd.13010

Borsato, K.T., Parizotto, J.O.L., Bianchi, J., Ramos, A.M.B.L., Gonçalves, J.R. Reverse engineering for post-treatment analysis of a surgical-orthodontic case (2022) Journal of clinical orthodontics : JCO, 56 (10), p. 1000.

View › | DOI: 10.3390/s22197258


Research and Scholarship

Cong, A., Ruellas, A.C.D.O., Tai, S.K., Loh, C.T., Barkley, M., Yatabe, M., Caminiti, M., Massaro, C., Bianchi, J., Deleat-Besson, R., Le, C., Prieto, J.C., Al Turkestani, N.N., Cevidanes, L. Presurgical orthodontic decompensation with clear aligners (2022) American Journal of Orthodontics and Dentofacial Orthopedics, 162 (4), pp. 538-553.

View › | DOI: 10.1016/j.ajodo.2021.12.019

Chang, S.W., Gaudin, A., Tolar, M., Oh, S., Moon, S.-Y., Peters, O.A. Physicochemical and biological properties of four calcium silicate-based endodontic cements (2022) Journal of Dental Sciences, 17 (4), pp. 1586-1594.

View › | DOI: 10.1016/j.jds.2022.04.001

Contact Insight

Have a suggestion for the next issue of Insight? Contact Dr. David Ojcius, Assistant Dean for Research and Co-Chair of the Department of Biomedical Sciences, for editorial suggestions or to learn more about how to get involved in research at the Dugoni School. Email:

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