T2D: AN ADAPTIVE BREAKDOWN & How to Take Corrective Action Quickly.

Dr. Joseph P. Kametz, DC, Regenesis Health & Body Research and Creative Director

Dr. Kametz was a sick kid during his entire childhood. He was diagnosed with asthma at age five, an auto-immune disorder. His parents always kept antibiotics in the refrigerator and he had frequent trips to the ER. After three major asthma attacks in his 20s, he was introduced to the Gonstead Chiropractic system, which changed his life forever. Not only did his back pain and sciatica go away, but he was miraculously healed of asthma. From that point, he left his career as a software consultant at one of the largest technology companies in the world. And he went back to grad school to pursue his doctorate in chiropractic with an emphasis on the Gonstead system, human anatomy, and physiology. This was over 20 years ago. As he dove deeper into chiropractic philosophy, his mindset on healthcare completely shifted. His philosophy on health was that the body is innately intelligent and makes the correct decisions for survival. Eventually, outside of very acute conditions or trauma, his views on medicine also changed drastically. He believes the body makes intelligent, but sometimes unhealthy, decisions for survival in response to different forms of stressors to the body.

Li Kametz, Regenesis Health & Body Founder

Li holds a Bachelor’s of Science in Information Systems and a Master’s in Industrial Organizational Psychology. She is also a Certified Nutritionist.

Prior to starting Regenesis Health & Body, Li worked at the largest healthcare company in the world and has over 20 years of experience in creating comprehensive programs at large and small companies, managing global teams and projects, redesigning and codifying corporate protocols to streamline business processes, implementing technology to automate systems, accelerating company growth, and starting and advancing new businesses. Through this journey, she discovered her true passion was in leading a revolutionary path in health, wellness, graceful aging, and natural beauty. She is driven to restore the confidence and beauty that is outward and within all people. Her mission at Regenesis Health & Body is to provide a complete restart for all people to achieve their optimal health, wellness, and physical appearance goals within an encouraging timeframe. She is focused on accomplishing this by adhering to a healthy, non-invasive, and natural protocol that is also sustainable long term.

In this document, we will explain the diseases of civilization through the lens of the innate intelligence of the body. By understanding the body’s intelligent adaptation to stress, you will understand why you’re not a slave to genetics, but a product of your body’s intelligent adaptation over long term stresses. This will empower you to start making wiser decisions and understand the great deal of control over your health. This is applicable not only to Type 2 Diabetes (T2D), but to cardiovascular/heart disease (CVD), obesity,

Philosophy on Health

Your philosophy of health will determine your belief and actions. There are two views. One is that the body has an innate wisdom, what Walter Bradford Cannon (American Physiologist) called the “wisdom of the body.” Or you may believe the body will usually need outside help (typically with a chemical) to fix it.

Imagine a creationist and an evolutionist staring at the Grand Canyon and the evolutionist says to the creationist, “Look at that Grand Canyon; it took a tiny river millions of years to create that!” And the creationist looks at the Grand Canyon and says, “It took one gigantic flood 40 days to create that”. How can two people see the same condition, the Grand Canyon, and have completely different ways of how it got there? Both evolution and creation are belief systems. No one has any observable evidence because no one saw evolution nor creation take place. Yet, they have the same data and draw completely different conclusions from it.

Medical philosophy generally looks at diseases as something that is genetically determined or luck of

etc. We encourage everyone to reflect on their own personal health philosophy. Then, you can understand the ‘Stress Cycle’ through your ‘innate lens’. By default, you may already have a philosophy on healthcare that is similar to most people, even though healthcare today is far from where it should be. But once you free yourself from that, a whole new world of health aligned with healthier decisions and options will open up to you!

the draw. Because you can’t change genes, you have no choice or no control over medical conditions. With this, the logical conclusion to fix most conditions is through treatment with drugs and/or surgery.

In 2013, a famous celebrity believed she had a 65% increased risk of breast cancer because she had a BRCA1 gene. Because she believed so strongly that genes ultimately determined her health, she had a preventative double mastectomy performed1. This is the logical conclusion of this belief system. If you can’t change your genes, and you don’t want to get breast cancer, cut off your breasts, and now you can’t get breast cancer. There is no judgement on this decision, but she took actions based on some medical advice and her health philosophy. If you take this to its logical conclusion, when migraine meds stop working, would you cut off the head? That’s silly, but being completely logical, this is the end result. What this also showed was that she did not believe making wise lifestyle choices really mattered (eg., eating well, avoiding chemicals in food and her surroundings, getting good sleep, exercising).

As Doctors of Chiropractic, we believe that there is an innate intelligence in the body. We don’t see conditions as medical diseases, but conditions the body creates by adapting to environmental stresses, (physical, chemical, electro-magnetic, mental, emotional).

Your body takes last night’s hamburger and turns it to eye cells today. Your body raises your temperature (fever) if it needs to kill off an infection. Your body takes what you eat, keeps the good and excretes the bad. If you ingest poison, your body violently vomits to get rid of it, without you thinking. The body is gloriously intelligent.

You can largely control your environmental

stresses. Therefore, you have some power because your decisions do affect your outcomes. You can control the foods you eat, if you exercise or not, how many hours you sleep, how much media you are exposed to, etc. Obviously, you can’t control pollution of the water or air, but you can have a water and air filter in your house.

Genetics absolutely play a very important role, but if only genetics was the cause of T2D, cancer, or heart disease, no one in history could have ever recovered from these things because genetics can’t be changed. However, with wise lifestyle decisions, you can make changes. That is the entire premise of epigenetics!

Additionally, if medical philosophy ever embraced the concept of epigenetics, it would completely change their industry, as they would have to admit that your choices largely control your health, not just your genetics.

To this point, there are even chemical stresses from our environment that may contribute to the diseases of civilization. For example, in 2019, the Los Angeles County Board of Supervisors ordered

the county to cease using glyphosate-based herbicides (eg., RoundUp) after it was known to cause cancer8. New York, Portland, Maine, and cities in Florida have also banned use of it.

Your philosophy of health absolutely matters. Because it determines if you put your hands in the fate drugs and surgery OR you can make better choices to make a positive change on your health and well-being.

Types of Stressors

A stressor is anything that causes the body to change physiologically. It can come in multiple forms.

PHYSICAL – too much food, damaging exercise, inactivity, poor sleep, traumas

CHEMICAL – artificial food/ingredien ts, GMO foods, pesticides, polluted air and water

FORMS OF LIGHT – x-ray, UV

There is good stress (hermetic stressor) and bad stress. A stressor could be good or bad. For instance, weightlifting is a stressor. If you lift weights to a point of momentary muscular failure and have adequate rest, your muscles will grow stronger. This is an example of a hormetic stressor.

The Nervous System

Your nervous system is divided between the Sympathetic Nervous System (SNS) and the Parasympathetic Nervous System (PNS). The SNS is there to adapt your body to stresses that threaten your life, often referred to as “Fight of Flight.” The PNS, commonly referred to as the “Rest and Digest” or “Feed and Breed”, is the part of the nervous system responsible for body repair. The big idea is that your body uses SNS

MENTAL/ EMOTIONAL – social media, politics, financial, family, heartbreak

ELECTROMAG NETIC FIELDS – cell phones, 5G towers

TEMPERATUE AND OTHERS

This is considered good. However, if you keep lifting after failure or at high intensity for extended volume and time, you can injure yourself. That is a negative stressor. Either way, a stressor changes your physiology, for the better or worse.

dominance, or FoF, to overcome a short-term stressor. However, if theses adaptations last over extended periods of time, you can eventually develop diseases of civilization like cardiovascular disease, obesity and/or T2D.

Whether it’s physical, chemicals in foods, air and water, emotional, EMF 5G, it doesn’t matter; the body reacts to different forms of stress.

The Intelligent Adaptation of the Body to Stress

Here’s a simple example. In today’s context, imagine you’re driving on the highway, and someone cuts you off. Immediately, through your five senses, the amygdala recognizes this stress, the HPA axis kicks off, and your body releases adrenaline and cortisol.

Everyone has felt this rush of adrenaline. Adrenaline gets you amped up and ready to fight or run away from danger. There are a series of things that happen with adrenaline and cortisol release. Here are just a few:

Your heart rate increases and blood pressure will rise. Why? Your body will need to send hormones, energy, and other chemicals in the blood to the cells fast!

Your LDL cholesterol will increase. Why? LDL is considered the bad cholesterol because it’s sticky. If your body is prepping for a car accident, you want your blood to clot.

These are intelligent adaptations to prepare for danger. These adaptations can keep you alive even

Let’s distinguish your body’s intelligent adaptation to stress from being healthy. What does it mean to be intelligent, but not healthy? Imagine climbing Mt. Everest and you get stuck in a storm. It’s colder than you planned, and now your toes and fingers are getting frostbite. With the passage of time, the more blood that stays in the extremities, the cooler the blood will get and you could die of hypothermia. But the body purposefully moves

blood to the most vital organs near the core for survival. Now, if you get out of that situation quickly, you may still be alive, though you might lose your fingers. Obviously, if you’re stuck in the cold for too long, your core temperature will get too low and you will die. But your body will buy you time by sacrificing the limbs to preserve life. This is just one example of innate intelligence on display!

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From Hunter Gatherers to Keyboard Warriors

Go back to the beginning of humankind, stresses were very different. We had to survive warring tribes or running away from wild animals. The body’s physiology needs change to survive. If a woolly mammoth was running at you, you need to do everything you can do to get away. Thus, the body prepares you for FoF by moving towards SNS dominance.

Once the stressor is over, the body can transition back to a more PNS dominance, the feed and breed, rest and digest, and repair part of the nervous system. And that is how the cycle was meant to work. A healthy balance between SNS and PNS.

Today, we are not often exposed to these life-threating stresses. However, in today’s time, micro-stresses never stop. These are some examples. You avoid a car accident and just as you’re winding down, you get that unexpected tax bill. Now, you’ve got 10 minutes to get to school to pick up the kids and you’ve already been late for pickup two times this week. On the way to school,

you get a flat tire. Now you’re really late. They repair your tire at the gas station, but now you’re craving junk food; so you’re stress eating while you’re head down scrolling through social media posts.

These little micro-stresses keep the body in a constant state of FoF and never let you get out of SNS dominance. Notice in this example, you had physical and mental stress from the near car accident, emotional stresses from bills, picking up the kids, popping a tire, and chemical stress from the candy bar. And your day isn’t even over yet. So your heart rate will stay a little higher, your blood pressure will stay elevated, your LDL cholesterol will stay higher. Imagine these micro-stresses lasting for over 30 years. Does this sound like heart disease?

Medical philosophy says to treat the effects, the poorly functioning heart. From a vitalistic standpoint, if you can control your stressors (listed on page 2) and response to stressors, you can also change your outcome!

The Stress Cycle and Diabetes

When you’re in FoF, you need energy. It’s very energy intensive to run the stress cycle. Have you ever noticed that when you’re stressed out, you want food? Unfortunately, you do not crave meat and vegetables. You want highly processed, high-calorie, high-sugar, high-fat junk food. During cycles of stress, you’re craving more sugar. And this can be the pathway to T2D and obesity. When the body releases adrenaline and cortisol during SNS dominance, it downregulates the thyroid gland; so the body can conserve energy. Why conserve energy? Your body conserves energy because it has no idea how long it needs to run away from the tiger, fight the war, or more appropriately today, fight with your spouse. Intelligently, to conserve energy, your body stops burning sugar. However, sugar is your primary energy source, and if you don’t burn sugar, it will

accumulate in the blood. Too much sugar in the blood is dangerous (diabetes); so your body protects you from diabetes by increasing insulin levels. Insulin pulls sugar out of the blood stream for storage, and what isn’t stored as glycogen is stored as fat. So think of insulin as the fat storage hormone.

And the longer you’re in FoF, you will crave more calories than you need for normal function of the body to stay alive, which continues to increase sugar and insulin in the blood. This whole stress cycle creates more inflammation and extra inflammation damages cells. Damaged cells become resistant to insulin. Eventually, the pancreases can’t produce enough insulin to keep blood sugar low enough and now you’re officially a Type 2 Diabetic.

The Physiologic Relationship Between Weight Gain and T2D

“Over the last five years, I haven’t changed my diet and I go to the gym three times a week and still gained 30 lbs.! Why?”

Always start with the knowledge that the body is intelligent and doesn’t make mistakes; it’s our interpretation that is incorrect. Cortisol downregulates the thyroid hormone which cuts out non-essential functions that take a lot of energy to operate. One of those processes is immunity. Why would you need to fight off sickness when your body is concerned about surviving an acute situation? Ever notice when you’re very stressed, you’re more susceptible to the common cold, or worse?

When you’re chronically stressed, your body needs fewer calories because it’s only performing essential functions at that time. The other calories will be stored. For example, let’s say your BMR (Basal Metabolic Rate2, how many calories you need per day to maintain body functions while resting) is 2000 calories a day. After being stuck in this stress cycle with all non-essential processes not being used, you may now only need 1900 calories. If you’re still eating the same amount as before, you now have a 100 calorie a day surplus. You’re storing all that extra sugar as fat. This eventually can lead to more sugar, more fat, more insulin resistance, diabetes, and more obesity.

Intelligently, your body converts sugar to fat when stored. Fat is more calorie dense than sugar. For every 1 gram of sugar, there are 4 calories (energy units). One gram of fat has nine calories (energy units). Fat is the most efficient way to store energy.

This is exactly why there is a direct relationship between weight gain and T2D. And you might as well lump hypothyroidism along with other diseases of civilization together too, as the body is intelligently responding to a chronic stress cycle. It’s that simple.

When you have an understanding of the body’s adaptation to stressors, you will eventually see these are not necessarily diseases, but conditions that happen as the body intelligently adapts to stress over the long term (before the breakdown).

Adaptation is a sign of life, but when this process breaks down, the body starts dying. If you look at these conditions from a medical standpoint, you see uncontrollable genetic pre-depositions and your lifestyle choices generally do not matter. So you are going to stay the course, possibly start with Glucophage, then Semaglutides, and eventually insulin. Clearly, some of these conditions are not genetic but the body’s intelligent way of adapting to long-term stress.

From this understanding of the stress cycle, T2D, obesity, heart disease, or others are all one and the same. Though the symptoms are different, they are all part of the effects of the same stress cycle. Most people with one of these conditions have other conditions too or will develop more given enough time and no change in lifestyle.

More on T2D and Weight Gain

Weight and Body Mass Index (BMI) is the simplest proxy for T2D and overall health. BMI is just a formal classification of your weight. It uses height and weight to put you into a category: Underweight, Normal, Overweight, and Obese Class 1-3. It is not 100% accurate, as in cases of very large and strong athletes or body builders. But in general, without doing any tests or blood work, it’s a good indicator. If you’re in the overweight or obese category, there is a very clear and accurate correlation to your overall metabolic health and how likely you’ll suffer from many of the diseases of civilization, including T2D. Click here to check your BMI online: https://www.calculator.net/bmi-calculator.html

A 2003 Journal of Biosocial Science3 article found that when using BMI to predict cardiovascular disease and diabetes’ specific mortality, ‘Obese Class 2’ individuals have a 34% increased risk of mortality and ‘Obese Class 3’ individuals have a 77% increased risk of mortality than one in the normal weight category.

Breaking it down for diabetes only, Obese Class 1 are 2.8x, Obese Class 2 are 4.7x, and Obese Class 3 individuals are 9x more likely to die of diabetes.

Notice in this study, heart disease and diabetes are grouped together. His shows the body’s adaptation to stress are one and the same, but with different symptoms based on the individual.

A 2007 study in diabetes care found that at 18 years old, if you’re very obese according to BMI, your lifetime risk of diabetes goes from 8% to 70%, compared to those who are under or normal weight at age 18. For women, that goes from 12% to 74%. So if you’re overweight, especially at a younger age, your risk of diabetes and overall mortality significantly increases4

In 20205, according to the CDC5, obesity combined with other metabolic comorbidities, specifically T2D, accounted for 60% of COVID hospitalizations. Your risk of hospitalization was greatly reduced by staying healthy. The data on weight and chronic disease is overwhelming and staggering.

Type 2 Diabetes & Weight Gain Cycle

Start Here

Stress

T2D and Obesity Disease Process Continues

Despair (mental/emotional) Chemicals in medication, Hormones, Junk Food (chemical) Weight Gain (physical) from the cycle add additional stress and the process builds. T2D, Weight Gain, and Disease of Civilization can progress.

Adaptation Breaks Down - Increasing Blood Glucose and Fat Storage

Pancreas cannot keep up with insulin demanded by the cycle. Fat storage increases.

Physical, Chemical, Mental/Emotional, EMF, and any other non-hormetic stressor starts and continues the cycle.

Cellular Damage & Insulin Resistance (T2D)

More insulin is needed to combat increasing blood glucose levels. Inflammation increases, causing cellular damage and insulin resistance.

SNS DominanceHormone Cascade

Adrenaline and Cortisol are released beginning and continuing a series of physiologic and anatomic adaptations.

Insulin Released by Pancreas for Fat Storage (Weight Gain)

Insulin is released to remove sugar from the blood to avoid damage from high blood glucose levels. Sugar is stored as belly fat for efficiency and future survival.

Energy Conservation via Thyroid Suppression

Not knowing how long the stressor will continue, the body intelligently prepares for the worst. Calories typically used as energy for physiologic functions will be stored. Non-acute, non-life-saving physiologic processes such as Immunity, Digestion, Healing, Memory, etc. are all suppressed.

Food Cravings Increase

Energy and raw materials are needed to support the stress cycle via high-calorie, sugary, fatty, junk food, despite a decreasing calorie requirement due to energy conservation.

Note

The cycle is used for presentation purposes only. There are many other processes happening in the cycle. Some of these processes run concurrently; some run even before the others. The order chosen is presented for ease of understanding of the cycle only.

You can break the cycle at any point. The easiest way to monitor where you’re at is by losing weight. Lifestyle change is a key way to break the stress cycle.

Start Reversing T2D by Breaking the Stress Cycle

Now that you understand the stress cycle thru vitalistic eyes, how do you reverse T2D? Simple. Break the stress cycle. How? Just stop feeding the cycle.

If you break the stress cycle and get a reset, not only can you potentially reverse diabetes, you can also reverse other chronic diseases and conditions. Many conditions can get better at the same time,

just by changing your lifestyle.

Since weight is a proxy for health and most chronic diseases, simply start by losing weight. It is a step you can take now and monitor yourself daily. Weight loss by only 5–10% is known to improve metabolic outcomes such as glycemic and lipid profile, thyroid panel, and blood pressure6

What Can You Do Right Now to Break the Cycle?

1

Know where you are and what your goals are. Look up your BMI rating (Underweight -> Obese Class 3)1: https://www.calculator.net/bmi -calculator.html

Get back on track if you’re in the ‘Overweight’ or above categories (and you are not a body builder or athlete).

2

Start time restricted eating today7. If you are insulin dependent or have an eating disorder, seek guidance from your physician first. https://www.health.harvard.ed u/blog/intermittent-fasting-sur prising-update2018062914156

3

Want to lose 15-25 lbs. in just over a month?

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*What if you’re not overweight? The stress cycle still applies to you. Start with 1 and 2 above.

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Low-glycemic, anti-Inflammatory, low-toxicity meal planning

Intermittent fasting

Proprietary mobile app to monitor and communicate with you in real time

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Off-boarding maintenance process to ensure you keep the weight off once you have completed the program.

You will be paired with a care specialist who has had first-hand experience with incredible weight loss. Some of our staff members were pre-diabetic in their 20s and have each lost over 100, 90, and 70 lbs. Now, they are all at a healthy weight with normal blood glucose levels, no longer pre-diabetic, and/or no longer has Hashimoto’s thyroiditis

a

We are located in North County San Diego, but our Healthy Living Weight Loss program can be done remotely with anyone in the US, Canada, or Mexico.

bClients local to San Diego may also benefit from our aesthetic body contouring services to cinch in additional inches in targeted areas while they are losing weight, creating an even more ideal figure.

We hope the information presented will be as life changing for you as all of the people in our clinic. Start your journey to better health today!

References

https://www.nytimes.com/2013/05/14/opinion/my-medical-choice.html

https://www.calculator.net/bmr-calculator.html

J Biosoc Sci. 2003 Jan;35(1):107-29.

Diabetes Care. 2007 Jun;30(6):1562-6. doi: 10.2337/dc06-2544. Epub 2007 Mar 19.

Effect of BMI on lifetime risk for diabetes in the U.S

https://www.cdc.gov/obesity/data/obesity-and-covid-19.html

Wing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG, et al. Diabetes Care. 2011;34:1481–1486. doi: 10.2337/dc10-2415.

Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes.

https://www.health.harvard.edu/blog/intermittent-fasting-surprising-update-2018062914156

https://www.usnews.com/news/health-news/articles/2019-03-22/los-angeles-county-bans-use-of-roundup-weed-killer