The Groundbreaking Discovery Of GG For Heart Health

The Groundbreaking Discovery of GG For Heart Health Restores CoQ10 Harmony and Assists With Statin Management

Your Gateway to a World Where Science Meets Wellness

Introducing the Experts Dr. Joel Kahn Meet our brand ambassador, Dr. Joel Kahn, MD. FACC, otherwise known as “America’s Healthy Heart Doctor”.

He is one of the world's leading cardiologists, a clinical professor of medicine, an integrative medicine practitioner and promoter of plant-based nutrition. He is a holistic cardiologist who strongly believes in the power of nutrition and supplements to help reduce disease risk, improve markers of heart health, and balance out dietary insufficiencies.

Dr. Joel Kahn has been an enormous asset to Xtendlife and continues his efforts to support in many ways. Dr. Kahn and Xtendlife’s unwavering mission to share good heart health advice, practices and supplements - so everyone can live a healthier, happier and longer life - is precisely why we've come together to design this informative guide to help you on your way to better health for many years to come.

Enjoy!

Dr. Joel Kahn, MD, FACC of Detroit, Michigan, co-host of Reversing Heart Disease Naturally Summit 2.0 by DrTalks. Dr. Kahn is a practicing cardiologist and Clinical Professor of Medicine at Wayne State University School of Medicine. He has a triple board certification in Internal Medicine, Cardiovascular Medicine and Interventional Cardiology. He was also the first physician in the world to certify in Metabolic Cardiology with A4M/MMI and the University of South Florida.

Dr. Barrie Tan Dr. Barrie Tan, PhD, American scientist and researcher, solved the problem of how to replenish GG in the body naturally. Dr. Tan is also a world expert on Vitamin E and Tocotrienols.

He has multiple PhD’s and has spent his career travelling and searching out solutions to issues that affect the health of our bodies. He was a pioneer in the field of Vitamin E and Tocotrienol research and uncovered a lot of misconceptions in the area of Vitamin E, which everyone should be aware of.

Xtendlife | The Groundbreaking Discovery of GG For Heart Health

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Contents What is GG (Geranylgeraniol)?

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Why Do CoQ10, Vitamin K2 and Skeletal Muscle Protein Matter?

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CoQ10 Importance and GG The Role of Vitamin K2 and GG Skeletal Muscle Protein and GG The Remarkable Benefits of GG for Heart and Muscle Health Uncover GG's pivotal role in managing SAMs

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Research About GG Who Should Take GG? Xtendlife's Science-Based Supplements for Heart Health

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GG Pure by Xtendlife Xtend-Quinol by Xtendlife DrTalks Summit Special

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More Support for Heart Health

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About Xtendlife: Who We Are

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References

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Xtendlife | The GG -Groundbreaking The Hidden Nutrient Discovery of GG For Heart Health

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What is GG (Geranylgeraniol)?

Have you ever heard of GG? No, it’s not a trendy new acronym. It’s a naturally produced nutrient in your body with amazing health benefits. But there’s a good chance you’re not getting enough of it.

GG stands for geranylgeraniol, a type of lipid involved in the synthesis of several vital compounds in your body, such as coenzyme Q10, vitamin K2, and skeletal muscle proteins. These compounds are essential for maintaining your heart health, bone health, and muscle strength.

But here’s the catch: your GG levels can decline with age or due to certain medications, such as statins, bisphosphonates, and warfarin. This can also lead to reduced coenzyme Q10, vitamin K2 synthesis, as well as muscle loss and weakness - that can mean serious consequences for your health and well-being.

GG

AGING

Co Q10 Activates CoQ10 Production

GG

MEDICATION

Co Q10 Promotes Muscle Function & Strength

Restores Vitamin K2 for Better Calcium Metabolism

REDUCED CoQ10 Production

IMPAIRED Muscle Function & Strength

INTERRUPTED Calcium Metabolism

Fortunately, there is a way to restore your GG levels and reap its benefits through supplementation.

Scientists discovered that GG can be naturally derived from annatto, a plant from the Amazon Forest with bright red-orange seeds. Taking GG supplements regularly helps to support GG levels in the body, which further optimizes coenzyme Q10 production, vitamin K2 performance and skeletal muscle protein formation.

THE AMAZON RAINFOREST

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Why Do CoQ10, Vitamin K2 and Skeletal Muscle Protein Matter?

Many of us recognize CoQ10 (Coenzyme Q10) as the heart's superhero. However, you might be curious about the connection between calcium, muscle protein, and heart well-being. Let's explore together.

Firstly, it's crucial to understand a biological process in the body known as the mevalonate pathway.

Cholesterol and GG are produced in this pathway at the cellular level, playing a vital role in heart health and beyond. Since CoQ10, vitamin K2, and muscle protein synthesis are also linked to the mevalonate pathway, it implies that cholesterol and GG can influence protein prenylation, impacting the cellular functions of CoQ10 and vitamin K2[1,2,3,4].

We know that elevated cholesterol levels can increase the risk of cardiovascular diseases. However, it's noteworthy that low levels of GG can also affect the health of the mevalonate pathway, consequently Influencing CoQ10 levels, calcium deposits, and muscle strength.

The Normal Healthy Mevalonate Pathway

Activates CoQ10 Production

Promotes Muscle Function & Strength

CoQ10 Importance and GG CoQ10 is short for Coenzyme Q10, it is a vital element for sustaining life and promoting overall well-being, it's especially crucial for cardiovascular health and energy production.

Low levels of CoQ10 can potentially lead to health issues such as fatigue, muscle pain and weakness[5]. Factors like age, genetics, nutrition, and medications (statins) can hinder the body's natural CoQ10 production, particularly impacting those with chronic conditions like heart disease.

Restores Vitamin K2 for Better Calcium Metabolism

"People with chronic conditions have notoriously low levels of CoQ10" Research found that people with chronic conditions such as heart disease and type 2 diabetes have notoriously low levels of CoQ10 in their system[5].

Hence ubiquinol supplementation is often recommended for people to help reduce cardiovascular health risks, especially for patients on statins.

Xtendlife | The Groundbreaking Discovery of GG For Heart Health

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GG is the building block of CoQ10[1], encouraging the natural production of CoQ10 in the body system.

Supplementing GG and CoQ10 together can also enhance the bioavailability of CoQ10. Additionally, GG only has a third of the CoQ10 molecular weight, which means it can easily diffuse inside cells and organelles.

GG Smallest of the "small molecules" Easy to absorb into cellular membranes CoQ10 Largest of the "small molecules" Difficult to absorb & get into membranes

Chemical Structure

CoQ10 Chemical Structure

The Role of Vitamin K2 and GG Vitamin K2 plays a crucial role in various biological functions, with a primary focus on blood clotting and bone metabolism. Its activation of proteins is essential for directing calcium deposition toward bones and teeth, preventing undesirable accumulation in arteries, and causing arterial calcification[6].

The mevalonate pathway contributes to vitamin K2's efficacy by providing GG (geranylgeraniol), supporting the proper functioning and cellular localization of the activated proteins.

Skeletal Muscle Protein and GG When we talk about skeletal muscle protein, we're talking about the superhero of muscles and bones. Skeletal muscle protein is vital for the structural integrity & function of muscles, including overall muscle strength and endurance. These are important for people over 50, especially for those who are on statin drugs.

Adequate protein intake and the promotion of muscle protein synthesis are essential for maintaining optimal health and wellbeing.

GG in the mevalonate pathway – it's like the behind-the-scenes hero, which indirectly influences skeletal muscle protein synthesis through its role in post-translational modifications, supporting muscle growth and function[7].

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The Remarkable Benefits of GG for Heart and Muscle Health By replenishing natural levels of coenzyme Q10, vitamin K2, and skeletal muscle proteins, GG offers protection against age-related physical decline, maintains structural integrity, and combats muscle fatigue[3].

The effects of GG supplementation are far-reaching. Here are just a few you can expect from adding GG to your health regimen[3,4,8]:

•

GG supports healthy cholesterol levels and prevents calcium buildup in your arteries, which can lower your risk of heart disease and stroke.

•

GG enhances your heart muscle function and energy production, which can improve your cardiac output and endurance.

•

GG stimulates protein synthesis and prevents muscle wasting, which can increase your muscle mass and strength

•

GG reverses muscle fatigue and weakness, which can improve your physical performance and quality of life.

Muscle fatigue and weakness are also common side effects of statin drugs.

•

GG increases your bone mineralization and prevents bone loss, which can reduce your risk of osteoporosis and fractures.

Sounds impressive, right?

Xtendlife | The Groundbreaking Discovery of GG For Heart Health

Dr. Barrie Tan, a researcher on lipid-soluble nutrients, has conducted several studies on GG and its effects on human health. He has found that GG can restore coenzyme Q10 and vitamin K2 levels in people who take statins, bisphosphonates, or warfarin, and improve their cardiovascular and skeletal health. He has also found that GG can increase muscle protein synthesis and reverse muscle fatigue and weakness in older adults[9,10,11,12].

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Uncover GG's Pivotal Role in Managing SAMs* High cholesterol is a common health concern for many, over 40 million Americans rely on prescription statins to keep it in check. That's a staggering number, and it's not slowing down – from 2002 to 2012 statin use almost doubled, and it may reach 80 million by 2030.

Statin Usage in the United States

Statin usage nearly doubled from 2002-2012 40 million Americans currently take statins The number of statin users is expected to double again in the next 10 years.

However, a significant chunk of statin users are facing some hiccups. Why? Because statins interfere with the production of GG in the mevalonate pathway, and when it takes a hit, so does CoQ10 (a vital energy booster for your body) and vitamin K2, causing common side-effects such as muscle pain and weakness[13,14].

According to research in March 2022[15], muscle pain is strongly linked to statin use, with 73.5% of individuals experiencing this discomfort, often leading them to consider discontinuing their medication.

*SAMs stands for Statin-Associated Muscle Symptoms

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Research About GG Recent studies, such as the one published in the Journal of Clinical Lipidology in 2023[7], have indicated that GG supplementation can alleviate muscle pain and enhance muscle strength in individuals undergoing statin therapy. Patients who incorporated GG into their regimen reported feeling better and expressed higher satisfaction with their treatment compared to those who did not.

The study also indicated that CoQ10 is, at best, a partial statin solution, whereas GG may be a better solution to address SAMs (statin-associated muscle symptoms)[16]. Hence CoQ10 and GG combination may be used as a “statin companion” to satisfy the unmet need generated by statin’s usage[7].

View Full Study

Who Should Take GG? Overall, anyone who wants to support the health of the heart, bones, and muscles could benefit from GG by replenishing the loss of GG due to aging or medications.

If you are already on statins and having side effects, such as muscle discomfort, GG supplementation is highly recommended. It has the potential to complement statin therapy for individuals experiencing SAMs, such as muscle pain and weakness.

A FRIENDLY REMINDER: Before starting any supplement regimen, it is advisable to consult with your doctor, especially if you have a diagnosed heart condition or are taking any medications.

Xtendlife | The Groundbreaking Discovery of GG For Heart Health

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Xtendlife's Science-Based Supplements for Heart Health GG Pure: Support proteins and cellular function Support CoQ10 production and cholesterol synthesis Recommended for statin users

LEARN MORE

A groundbreaking natural supplement featuring annatto seed extract to support geranylgeraniol (GG) levels for cardiovascular support and healthy aging.

GG Pure contains a unique extract from annatto seeds, which is known to be one of the richest natural sources of GG. Extensive research has been conducted on this extract to confirm its safety and effectiveness in replenishing GG levels that decrease with age or due to certain medications like statins and bisphosphonates.

By boosting the levels of Geranylgeraniol (GG), which is essential for CoQ10 production, GG Pure can help enhance heart health, metabolism of cholesterol, and shield organs from age-related deterioration.

Studies have also shown that GG may aid in maintaining muscle health, particularly for individuals experiencing weakness related to aging or as a side effect of statin use.

GG is involved in protein prenylation within the mevalonate pathway, influencing various cellular processes including bone metabolism. It facilitates the activation of vitamin K and proper calcium localization, crucial for bone and arterial health.

Whether you are over 45 or taking medications, GG Pure could be a beneficial addition to your wellness routine to support your overall health objectives.

Xtendlife | The Groundbreaking Discovery of GG For Heart Health

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Xtend-Quinol High dose of bioactive CoQ10 (100 mg) Support healthy aging Recommended for statin users

LEARN MORE

A powerful innovative synergy of ubiquinol CoQ10 and geranylgeraniol to support heart health and healthy aging.

Xtend-Quinol has been formulated to assist in maintaining CoQ10 levels, promoting heart health, and supporting healthy aging. It contains DuoQuinol®, a cutting-edge scientific combination of CoQ10 and geranylgeraniol (GG), offering a comprehensive solution for overall well-being.

Energy Support: The heart requires a substantial amount of energy at the cellular level to maintain constant contractions and effectively pump blood throughout the body. Xtend-Quinol provides a potent form of CoQ10 known as ubiquinol, the active form that rejuvenates cells and enhances vitality.

Heart Health Support: Ubiquinol plays a crucial role in supporting and strengthening vital organs, particularly the heart. The ubiquinol CoQ10 in Xtend-Quinol is in its non-oxidized form, identical to the naturally occurring ubiquinol CoQ10 in the body. This unique CoQ10 formula includes geranylgeraniol (GG), essential for promoting healthy aging. GG serves as a precursor to CoQ10, facilitating natural CoQ10 production and supporting muscle function and strength, beneficial for individuals experiencing side effects from statins.

"I believe heart disease is preventable, we know the factors. Heart disease is reversible, we know how to do it - even if you’ve already suffered a heart attack.

How? Through lifestyle change and great supplements.

That’s why I’m so glad I found Xtendlife’s range of heart support supplements.

They’ve literally blown me away” Dr. Joel Kahn, MD, FACC Xtendlife Heart Health Brand Ambassador

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Restores harmony and assists with statin management, stay ahead in the quest for a healthier you!

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Restores harmony and assists with statin management, stay ahead in the quest for a healthier you!

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More Support for Heart Health CX8 Cardiovascular Support A unique, highly advanced natural supplement formulated with a synergistic combination of clinically proven ingredients to support the cardiovascular system.

CX8 is designed to:

• Heart and artery support from a cellular level • Manage arterial calcification • Healthy cholesterol balance How does it work?

Through the synergistic action of 8 ingredients, CX8 aims to improve heart health and support against arterial calcification. The ingredients include: DeltaGold® Tocotrienol Complex, Rutin, CardiOmegia™ Sea Buckthorn Fruit Extract, CyanthOx™ Proanthocyanidin, Vitamin D3, Vitamin K2, Nattozimes® Protease, and Blackcurrant Extract.

LEARN MORE

VasQFlow A potent natural heart health supplement combines the benefits of red spinach, black garlic, and 9 ingredients to support nitric oxide, one of the most essential molecules for optimal blood circulation.

VasQFlow is designed to:

• Support circulation to prevent cold hands or feet • Support healthy blood pressure • Support oxygen delivery to cells and organs How does it work?

While nitric oxide may have been flying under the radar over the last 20 years, it is now becoming widely appreciated for its therapeutic benefits and the important role it plays in several areas of our health.

With its many benefits, VasQFlow is a perfect addition to add to your current cardiovascular support regimen - and it is compatible with all other Xtendlife products.

LEARN MORE

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About Xtendlife: Who We Are Xtendlife is a natural supplement company located in the beautiful land of New Zealand. Founded over 25 years ago, the company strives to provide dietary supplements containing only the best possible ingredients.

The Xtendlife supplements and quality meet the approval of “America’s Healthy Heart Doctor” - leading cardiologist, Dr. Joel Kahn.

Evidence-Based Nutrition for Your Heart SHOP HEART HEALTH

In 2022, Xtendlife was nominated as one of the 10 Best Companies in Nutraceutical Market, November 2022.

Xtendlife is on a mission to provide people with the foundation for better health that enhances their quality of life - using the power of science and nature alongside the core values: Integrity, Purity, Innovation.

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References 1

STOFFEL, W. et al. Synthese der K Vitamine and Ubichionone. Agnew Chem. 1960;72(17);627-627

2

https://r-statistics.co/Complete-Ggplot2-Tutorial-Part1-With-R-Code.html

3

https://www.wholefoodsmagazine.com/articles/3268-a-new-supplement-brings-many-health-benefits-gg

4

https://www.xtend-life.com/blogs/supplement-ingredients/geranylgeraniol

5

https://www.mayoclinic.org/drugs-supplements-coenzyme-q10/art-20362602

6

https://pubmed.ncbi.nlm.nih.gov/34785587/

7

https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1246589/full

8

https://www.casi.org/node/1060

9

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315720/

10

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646228/

11

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646229/

12

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646230/

13

https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.120.046542

14

https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1246589/full

15

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9034880/#

16

CAMPIA, I. et al. Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1cells, without decreasing the beneficial effects on cholesterol synthesis. British Journal of Pharmacology. Dec 2009;158(7);1777-1786.

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