Pharmaceutical Brochure website

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PHARMA & BIOTECH

with Repeat Clients

Turner provides building services to clients who value diligence, resourcefulness and creativity. Because Turner is a global company based in North America, we are able to offer clients the accessibility and support of a local firm with the stability and resources of a multinational organization.

BY THE NUMBERS

1,060 Pharma projects completed $800 Million Average annual Pharma & Biotech work

DEDICATED MARKET SEGMENTATION

Pharma & Biotech building requires a higher level of expertise given the process integration component along with complex mechanical and electrical systems, piping, cleanroom, and equipment installation. Turner’s industrial team specializes and focuses on these unique aspects throughout the construction process.

25 Million sq. ft. of pharma facilities built

Consistently ranked as a Top P harma Builder in the US ENR, Last 10 Years

400 Pharma Specialists across the US

National Pharma & Biotech Market Segment Specialists

Our Pharma & Biotech Market

Segment Specialists are travelers and can relocate to project locations across the US.

Our team is currently supporting 15 active projects across North America.

The local offices can supply Safety, Estimating, QA/QC, & MEP Specialists as required.

Mike Hamrick MEP Superintendent

Mark Stango Superintendent

Brandon Lapeus Superintendent

David Welch Sr. MEP Superintendent

Kevin Paugh MEP Superintendent

David Watson Precon Manager

Bob Goworek Vice President

Jim Gaughan Project Executive

David Semsey Precon Manager

Michael O’Mahony Senior Engineer

Greg Peters Project Manager

Bubba Chism Construction Exec.
Vince Myers Superintendent

Capabilities & Services

Turner’s Pharma & Biotech Group focuses exclusively on technical issues for biopharmaceutical / biotechnology industry clients. This technical services group includes individuals with engineering degrees (including chemical, biologic, biochemical, mechanical, and electrical, as well as advanced post-graduate degrees) along with members who have experience with design, installation and operation of ultra pure water systems, pure gas systems, high purity piping and clean-rooms.

We serve each of Turner’s 55 business units, traveling to job-sites as needed to provide the highest level and quality of support to our project teams and clients.

We have established procedures and systems necessary to control the project delivery process and we have managed some of the most sophisticated and challenging pharmaceutical and biotech manufacturing projects in the world. Our clients have received numerous awards including: Lab of the Year (ENR) & Facility of the Year (ISPE).

“I have worked with Turner over the past 15 years where they have been the Construction Manager responsible for both construction and commissioning of complex manufacturing facilities such as biologics, sterile fill plants, and OSD plants. They have done this work in both the USA, PR and Europe for J&J. They are delivering dynamic complete facilties.

Jim Breen, Johnson & Johnson

Capabilities & Services

We work with the Client and the Design Partner and have the necessary understanding of the process to support and/or manage the below activities:

Preliminary Conceptual Design

We are familiar with Process Simulation software; our staff has experience in initial facility master planning and BOD development.

Scope Development

We can help determine the client’s facility needs, constructability, cost, possible schedule.

Detail Process and Facility Programming

We can help determine the equipment and layout that best suits the client’s needs.

Process Design Scope Control

We work with the project team to help the client get the design they want, without exceeding their budget.

Design Review

We can provide a critical second look at design documents, not only for value engineering purposes, but for GMP compliance and constructability.

Equipment Selection

We can call upon our experience to make product, vendor and manufacturer recommendations.

Equipment Expediting and Factory Inspections

We perform periodic on site inspections to confirm equipment fabrication and delivery is on schedule and per the specifications.

Quality Assurance/Quality Control

We believe implementation and execution of a well-defined quality plan is essential to the successful commissioning, qualification and operation of a biotech / pharmaceutical facility

FAT/SAT Testing

We can develop Factory and Site Acceptance Test Plans and assist in their execution.

Commissioning

We can help develop and execute commissioning test plans in addition to managing the commissioning process.

Validation

We can manage validation, make recommendations about validation contractor selection and protocol development and assist with validation master planning and turnover package compilation.

Building the Best Teams in the Business

Turner combines its experienced technical specialists and its talented local organizations to create multiplied knowledge. Clients benefit from a deep understanding of industry trends, best practices and requirements, as well as solid relationships with communities, authorities and subcontractors on a scale unmatched in this field.

Capabilities & Services Select Client List

Turner is continually adding to its portfolio of consulting and service options, as we create new solutions for clients.

Turner staff ensures that process-driven projects are planned, engineered, constructed, commissioned and validated in accordance with cGMP, cGLP and other governing guidelines to meet the needs of our clients. This is accomplished by providing extraordinary technical expertise in the management of process facility engineering and construction from project concept through start-up, validation and turn-over into operations. More specifically, our process knowledge is focused on the high-technology aspects of a project, proactively managing the design, procurement, commissioning and start-up phase of the project, and integrating the validation tasks required in order to reduce both cost and schedule.

Turner provides the following range of services:

• Project Scope Development

• Regulatory Management

• Design Phase Management

• Value Engineering

• Process Constructability Reviews

• Technical Procurement

• Construction Technical Support

• Integrated Start-Up Coordination

• Validation Management

• Modular Construction

• Project Close-out and System Turnover

• Robust Commissioning Services

• Start-up Planning

Our technically-experienced staff has the knowledge and experience of the unique aspects of process projects that combined result in a successful project. We understand the impact of proper planning, complete budgeting, process

equipment procurement, clean construction, customized QA/ QC programs, the technical aspects of start-up and commissioning, and adherence to GMP design and construction.

Unique Options

Turner’s position as the nation’s leading builder enables us to leverage strengths and provide unique benefits for clients:

Strategic sourcing of many of the components and materials essential to projects, securing cost, delivery and planning advantages.

An array of risk management products and services for subcontractors and partners to protect investments, expedite processes and build additional single-source responsibility into projects.

We practice Lean Construction techniques such as pull planning, supply chain purchasing, off-site fabrication and justin-time material delivery on a number of projects nationwide. These techniques help us increase the safety and efficiency of our construction operations, improve the collaboration of our project teams, build confidence in our schedules and increase value to our clients.

Actavis

Agilent Technologies

Alexandria Center for Life Sciences

Alkermes

Allergan

Alltech

ALZA

Amgen Inc.

Arizona State University

Aventis

Battelle Memorial Institute

Baxter

Bayer

Becton Dickinson

Boehringer Ingelheim Roxane, Inc.

Biogen

Biogen-Idec

BioMed Realty

Bio-Rad

Bristol Meyers Squibb

Boston Scientific

Bridgeside

Cambrex BioScience

Carticel

Catalent

Celgene

Celularity, Inc.

Center for Applied Energy

Center for Disease Control & Prevention

Centocor

Century Therapeutics

Corden Pharma

Corixa

Covidien

Dendreon

DuPont Pharmaceuticals

Duquesne

ElevateBio LLC

Eli Lilly

Emergent

Emerson

Ethicon Endo-Surgery, Inc.

FDA

Fort Dodge Animal Health

Fred Hutchinson Cancer Center

Frick Chemistry

Genentech

Genmab US, Inc.

Genzyme

GlaxoSmithKline

Harborview Medical Center

Hikma

Hovione Technology

Howard Hughes Medical Center

IDEC Pharmaceuticals

Illumina, Inc.

Incyte

Intel

Intervet, Inc.

J. Craig Venter Institute, Inc.

Johnson & Johnson

Joyant Pharmaceuticals, Inc.

Kite Pharma, Inc.

Legend Biotech

Lucent

Lyme Properties

Maryland Public Health Laboratory

McNeil

MD Anderson Cancer Center

MedImmune

Memorial Sloan-Kettering

Merck

Millennium Pharmaceuticals

Millipore Global Properties

Mission Bay Life Sciences

MITMCO

Moderna, Inc.

Monsanto

New Jersey Public Health

National Emerging Infectious Diseases

North Carolina Research Center

New Orleans

BioInnovation Center

North Carolina Central University

Northern Kentucky University

Novartis

New York University

Otsuka

Patheon Pharmaceuticals, Inc.

Pfizer

Pharmacia

PrimaPharm

Princeton University

Proligo

Purac

Qualitest Pharmaceuticals, Inc.

Quest Diagnostics

Regeneron

Rockefeller University

Sanofi-Aventis

SHL Pharmaceutical

Schering-Plough

SHL Pharmaceuticals

STAQ Pharma

Stryker

Syngenta

Takeda Pharmaceutical USA, Inc.

Teva

Texas A&M University

University of Florida

UMDNJ

United Therapeutics

Urban Waters

Vanderbilt University

Vertex Pharmaceutical

Watson Pharmaceuticals

Westinghouse Electric Company

West-Ward Pharmaceuticals

ZymoGenetics

PRECONSTRUCTION SERVICES

Identifying Opportunities, Creating Value

INFORMED ANALYSIS

Preconstruction is a critical time for discovery and solutions-focused thinking. Turner’s role is to remove the complexities involved in the execution and delivery of the construction process to allow for collaborative, data-driven decision making.

Turner project management leaders are a knowledge network of construction-focused professional engineers and architects, product experts, procurements specialists, process managers, integrated multi-disciplinary performance model technicians, and community engagement managers. Our teams leverage experience working on similar projects to bring innovative ideas and, at times, alternative solutions to the table.

This effort will require multiparalleled paths focused on maximizing the program, design optimization, balanced budget, value management, innovative procurement strategies, and in-depth constructability analysis for quality and efficiency.

Project Development & Planning

Our Philosophy: Optimize Opportunities Early in Design

TRADE PARTNERS + LABOR POOLS

As the construction market continues to grow, it is no surprise that as a result, trade labor is becoming more thinly spread. Turner combats this by ensuring subcontractor availability through our centralized Procurement Team. We have full-time professionals buying every day, maintaining constant communication with the subcontractor market, with real time understanding of workload capacity.

MARKET ANALYSIS

Turner publishes several major reports on a quarterly basis using national statistical data from sources such as the Bureau of Labor Statistics (BLS), AGC, Urban Land Institute (ULI), OSHA, and local industry market media outlets to highlight current trends in the industry, both nationally and locally.

Data points include statistics such as safety, labor force, trade wage rates, largest regional active and completed projects. The data is also used to showcase the amount of available skilled labor in the construction labor pool.

The construction cost forecast has been prepared for over 80 years and is used widely by the construction industry and Federal & State governments.

Turner produces a quarterly market condition report, providing a global view of for our clients to use in site selection and long term planning groups. Turner’s Building Cost and Equipment Indices are determined by several factors considered on a nationwide basis, including labor rates and productivity, material prices and the competitive condition of the marketplace.

PRECONSTRUCTION SERVICES

Supply Chain Management

SourceBlue, a subsidiary of Turner Construction, is a competitive sourcing option for major MEP equipment and architectural products. SourceBlue is uniquely positioned, as one the largest buyer of MEP equipment in the nation, to facilitate collaboration between Turner’s Clients and hundreds of SourceBlue’s contracted suppliers, distributors, and manufacturers.

Staffed by 250+ national supply chain experts/procurement professionals, SourceBlue has procured and delivered over $7 billion worth of materials and equipment since 2001. In contracting directly with vendors and suppliers, SourceBlue will:

y Drive transparency in cost and quality of materials and equipment.

y Foster competition in the vendor market by sourcing both domestic and international vendors that may not otherwise be accessible.

y Early Bulk Purchasing, Prefab & Storage to Mitigate Risk

y Allow the design team to optimize the value engineering process.

y Stabilize the project schedule by having more control over lead times from the factory floor to the jobsite

SourceBlue Model Simplifying Our Clients Supply Chain & Procurement Channels

BY THE NUMBERS

PRECONSTRUCTION SERVICES

Offsite Construction & Prefabrication

PROVIDING INNOVATIVE SOLUTIONS

YEARS EXPERIENCE MANAGING GLOBAL SUPPLY CHAIN

STAFF SOLELY DEDICATED TO SUPPLY CHAIN SOLUTIONS

$1B+

EQUIPMENT+ PRODUCT PROCURED IN 2023

$7B+

EQUIPMENT+ PRODUCT PROCURED SINCE 2001

• Prefabricated Skids

• Super Skids

• Full Modular Rooms

• Appliances

• Plumbing Fixtures

• Residential Casework

• Laboratory Casework

• Light Fixtures & Lighting Controls Systems

• Ceramic & Porcelain Tile

• Natural & Artificial Stone

• Countertops

• Wood & Resilient Flooring

Terms like “innovative approaches,” “prefabrication solutions,” and even “industrialization” are the terms that orbit the big bold idea of managing supply chains. In truth, assembling and managing the resources, capabilities, and technology through the complex construction supply chains requires a deep understanding and established infrastructure. It requires a manufacturing mindset that can “productize” a facility – looking at all the parts and pieces to construct buildings simply and repetitively.

Turner has a highly experienced team xPL Offsite that has been delivering off-site, prefabrication elements to the benefit of our clients. While typical applications include doors, frames, and hardware, MEP systems and facade panels, our projects have employed offsite applications ranging from bathroom pods, to modular mechanical penthouses, to entirely modular buildings - including two of the tallest modular towers constructed in the world.

Benefits of Offsite Implementation :

PREFABRICATION STRATEGIES FOR c GMP MANUFACTURING FACILITIES

Project Endeavor in Frederick, Colorado, is a 215,200 sq. ft. expansion of an existing pharmaceutical manufacturing facility. The addition includes a 172,000 sq. ft. manufacturing lab, a 31,500 sq. ft. central utility plant and warehouse, and an 11,700 sq. ft. tank farm.

The new space is designed to produce bulk active pharmaceutical ingredients (APIs) following Current Good Manufacturing Practices (cGMP) and Process Safety Management (PSM) standards.

The project team implemented a robust field assembly strategy using prefabrication and modular construction to enhance efficiency, quality, and adaptability. Key components, such as $70 million worth of prefabricated process piping and equipment skids, were fabricated off-site in California and then assembled on-site, reducing labor needs by 40% for certain packages.

The project also features advanced clean room technology with fire-rated panels imported from Europe. These panels are specially designed to withstand the chemical processes involved, ensuring they maintain integrity in the controlled environment.

Design Optimization & Sustainability Resources

DESIGN MANAGEMENT

Through Turner Engineering Group (TEG)

Our in-house engineering resources collaborate with the team’s design partners to generate optimized solutions to complex technical challenges during the preconstruction. This process enables identification of hidden design risks while examining the best option that suits a specific condition in all disciplines of project development. Our reviews and evaluations can take on different forms: Technical Reviews, Risk Analyses and Operations/Systems Reviews

RISK FOOTPRINT + RESILIENCE ANALYSIS

Our RiskFootprint Report identifies the natural hazards and risks of a building or project location. The report includes both historical climate data and future climate estimates. Using information from the RiskFootprint report, we will prepare a Resilience Analysis that provides recommendations in relation to the natural hazards and risks as well as our client’s priorities and building resilience goals. Turner also prepares feasibility reports providing technical feedback on existing conditions with a focus on adaptive reuse objectives. We evaluate the program and identify the potential high risks. The goal is to aid our clients in pursuit of a high performance, energy and resource efficient, resilient projects.

EMBODIED CARBON + SUSTAINABILITY

Turner is redefining sustainability and elevating what it means to be a “green” builder. We are committed to reducing embodied carbon in building projects. We will outline reduction, re-use, and sequestration strategies in early design. As we identify optimizations and design and procurement strategies, we will also provide alternate systems and provide a holistic approach to quantifying greenhouse gas emissions. We will use our technical expertise to create a healthy, prosperous, and sustainable future for our people, clients, and the environment

EXPERTISE ACROSS DISCIPLINES
Centocor / Johnson & Johnson, Various Locations
Bio-Manufacturing Facility, RemiCap 150 Project and CNTO 148 Project
MedImmune P95/Area 6 R&D Laboratory, Gaithersburg, MD
Takeda Pharmaceuticals, Social Circle, GA
Johnson & Johnson, Building 185, Morris Plains, NJ
McNeil Pharmaceutical, Ft. Washington, PA
Howard Hughes Medical Institute, Ashburn, VA
New Orleans BioInnovation Center, New Orleans, LA
Centers for Disease Control and Prevention, Building 24, Atlanta, GA
Hovione Technology Center, East Windsor, NJ Allergan R&D III, Irvine, CA
Agilent Technologies, Frederick, CO
Vaccine Mfg. Facility, Swiftwater, PA
Kite Pharma Mfg. Facility, Santa Monica, CA
Westward Pharmaceuticals, Columbus, OH
UCSF Mission Bay Genentech Hall, San Francisco, CA
Genzyme Bio-Pharmaceutical Manufacturing Facility & Dual Fuel Cogen Plant, Allston Landing, MA
Maryland Public Health Laboratory, Baltimore, MD
Pharma Production Facility, Hillsboro, OR
Century Therapeutics, Philadelphia, PA
STAQ Pharma, Denver, CO
Vertex Pharmaceuticals, Boston, MA
Takeda Pharmaceuticals, Social Circle, GA
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