Cels Directory 2010

be well, connected

Driving the business of life sciences

M E M B E R S H I P D I R E C T O RY | 2 0 1 0

There’s a buzz about Helena Biosciences

al C l i n i c p h o re s i s ro El e c t

Full product range

l et Plate ation eg Ag g r

u l at g a o C

ion

re & u t l u gy eC T is su ula r Biolo c Mole

Tel +44 (0)191 482 8440 marketing@helena-biosciences.com www.helena-biosciences.com

MK03

Helena Biosciences have more than thirty years of expertise in clinical diagnostics and molecular products.

To ďŹ nd out how we can help you meet the challenges of 2010, please get in touch with us:

CONTENTS 005 Welcome 006 Cels - A focal point for Life Sciences in the North East 008 HealthConnect - Be Well Connected in the Region 011 Infrastructure and Incubator Facilities in North East England 013 International Investment in the North East 014 NEPAF - Your Partner in Proteomics 018 CBSL - Taking your Science to Market 020 CBSL - Case Studies 023 Driving the Growth of Enabling Technologies in Regenerative Medicine 024 Business for Life Awards 2009 025 Environment Award 026 Export Achievement Award 027 HealthConnect Award 028 Innovation Award 029 Outstanding Growth Award 030 Partnerships with the NHS Award 031 Start-up Award 032 Technology Award 063 Medical Devices feature 071 Associates 083 Assistive Technology Directory designed & produced by Distinctive Publishing 8th Floor Aidan House Sunderland Road Gateshead NE8 3HU T: 0191 4788300 Disclaimer Distinctive Publishing or The Centre of Excellence for Life Sciences Ltd (trading as Cels) cannot be held responsible for any inaccuracies that may occur, individual products or services advertised or late entries. No part of this publication may be reproduced, scanned or digitally stored without prior written permission of the publishers and Cels.

089 Biotechnology & Life Sciences 101 NHS & Clinical 115 Health Informatics 121 Health & Social Care 127 Medical Devices 135 Supply Chain 147 Key Industry Bodies 156 Members by Category 159 Advertisers Index

W W W . C E L S G R O U P. C O M 3

WELCOME

Welcome to the 2010 Cels HealthConnect Directory which showcases some of the exciting and diverse healthcare and life sciences initiatives taking place across North East England.

Here at Cels we are proud to be part of a thriving region and, over the last 12 months, we have supported over 230 companies and individuals involved in exciting and groundbreaking work across a wide range of fields. This directory gives you just a taste of some of these initiatives which help to secure the North East’s reputation as the place to do healthcare business.

During the past year, a period marked by unprecedented change and uncertainty, the North East region has risen to the many challenges it has faced brought on by the global financial crisis. The healthcare and life sciences sector has continued to innovate, to create new businesses and develop new plans for growth and prosperity. Money is being invested on infrastructure projects, and the region continues to attract further investment into research, collaborations and new partnership ventures.

HealthConnect, the Cels network for academics, businesses and clinicians, forms an important part of Cels’ work to unite people and organisations active in the sector across the region. Since it was launched in June 2009, the network has attracted more than 400 companies and individuals to join its membership.

Ambitious plans for 2010 will see the HealthConnect membership continue to grow, and the creation of a steering committee, a group of independent representatives constituted by the members, for the members,

to ensure effective delivery of the network’s activities. We are also looking to engage more actively with academic institutions throughout the region, including Northumbria, Sunderland and Teesside universities to create a truly panregional network.

Once again the Business for Life Awards was one of the highlights of Cels’ year and it celebrated the truly outstanding work that continues in our region. Our ambition for 2010 is to launch more award categories, develop an even greater degree of engagement across the sector and create more opportunities to showcase the region’s expertise in healthcare and life sciences.

Groundbreaking infrastructure projects will also be a key focus for Cels in 2010. We will continue to work with One North East to provide strategic input to the incubator project proposed for Cramlington, which aims to meet the increasing accommodation needs of early stage companies in our region. There is also a growing role for Cels in the planning of the Translational Research Building to be located on the General Hospital site which once completed, will provide an environment for a more efficient and effective translation of science into enterprise.

Cels continues to support scientific development in regenerative medicine through our involvement with the regeNer8 project, delivered by a consortium of Universities from across the North of England, which are active in the field of stem cell research and regenerative medicine. Throughout 2009 regeNer8 initiated a programme of collaborative research and development and technology validation projects including a new translational medicine award to stimulate collaboration between the sector’s academics,

clinicians and industry professionals. The aim of this funding is to drive the development of innovative solutions to unmet medical needs in the field of regenerative medicine and provide a boost to the local economy. We look forward to seeing the results of this award in 2010 once the projects are underway.

The past twelve months have been transformational for Cels as the Company has become less reliant on One North East funded projects. Contributing to this change has been a marked growth in the commercial performance of CBSL (Cels trading subsidiary). A number of important contracts have been won which have helped the Company establish a firm reputation across both the public and private sectors for excellence, and for delivering first class information and advice at a competitive rate.

CBSL continues to widen its own network and is tapping into new opportunities to help the growth and development of the healthcare and life science sector in Scotland. It has grown its team of consultants and its skill base in order to deliver high quality projects in the public and private sectors, and is supporting both start ups and established businesses in areas including investment, marketing, supply chain and sector analysis.

2010 promises to be another year of change, growth and prosperity for our sector and bringing organisations and activities together will create the leverage and weight needed to ensure the North East continues to punch above its weight.

Keep in touch with all Cels activities via our website www.celsgroup.com Mike Asher, CEO

W W W . C E L S G R O U P. C O M 5

CELS - A FOCAL POINT FOR LIFE SCIENCES IN THE NORTH EAST

Working at the heart of the life sciences sector in the North East of England, Cels is the hub for business development, R&D and healthcare.

Cels plays a significant role in the delivery of the North East region’s plans in healthcare and life sciences to drive the growth of the overall healthcare economy in North East England. The North East has a growing and dynamic industrial base that spans from multinational pharmaceutical companies to innovative spin-outs and start-ups in areas such as oncology and regenerative medicine.

Regional hub for life science Cels is committed to developing scientific enterprise through the development and commercialisation of new technology, innovations and the exploitation of new and emerging market opportunities. Cels drives growth in four main ways: n By building and managing first class business and research infrastructure n By placing the region on the world stage through internationally recognised networks n By managing emerging technology and stimulating the formation of new business ventures n By offering financial and management assistance to business start-ups.

To achieve this, Cels works in close partnership with the North East’s five regional universities, associated research institutes, healthcare and life science companies and public sector organisations. It offers access to these organisations for parties interested in research or business collaborations.

Our activity is focused on supporting partners in the following key sub-sectors: n Stem cells and regenerative medicine n Ageing and health (including Assistive

6 C E L S H E A LT H C O N N E C T

Technology) n Drug discovery and biomarkers n Diagnostics and medical devices n Biopharmaceutical process development

Our aim is to support and bring together the strengths of the region’s research, clinical and industrial expertise and create a compelling environment for business development and growth.

Specifically Cels aims to: n Support the region’s existing and new

healthcare and life sciences companies n Attract investment and new healthcare

organisations to the region n Help companies diversify into healthcare

markets n Connect to a global network of healthcare

and bio-clusters n Manage its regional network

HealthConnect for healthcare R&D and intercompany collaboration n Develop and operate business incubator and bioscience facilities (Cels at Newcastle Micro-Incubator and NEPAF) n Provide a wide range of commercial fore sighting and business support services via CBSL (Cels Business Services Ltd) Bespoke business support CBSL is a wholly owned subsidiary of Cels and provides consultancy services to support start-up and existing companies, universities and public sector clients.

Specialists in healthcare and life sciences, CBSL has an excellent track record of delivering consultancy services to clients in the private and public sector based on the wealth of expertise in the commercialisation of life science and healthcare technology.

With a strong team of consultants

focussing on the North East of England and Scotland, CBSL draws on over 100 years’ collective experience of working across sectors including industry, academia and the NHS, and in areas of innovation and commercialisation, project evaluation, economic development, research and technology transfer.

Network synergies in healthcare HeallthConnect, brings companies, scientists and professionals from across the healthcare and life sciences sector including areas such as assistive technology, biologics, health informatics and medical devices. By joining the network, members are able to access a range of customized support services, while the region as a whole gains from the synergies that occur when companies come together, pool resources, and share their knowledge.

HealthConnect delivers a range of first class support activities and services which are all designed to help members grow and succeed. These include: n Networking n Skills n Promotion n Research n Supply chain support n Technology initiatives n Encouraging investment n Market intelligence Micro-Incubator encourages shared experiences Cels has established and manages the Cels at Newcastle Micro-Incubator. The first of its kind in North East England, it has been designed to provide workspace specifically for life science and healthcare companies by utilising high specification wet laboratory

fixtures and fittings. The Cels at Newcastle Micro-Incubator promotes synergy between companies within the Micro-Incubator, leading external businesses and with Newcastle University through the development of networks and clustering of like minded companies. By encouraging the sharing of information, experience and business resources, an environment is created where business can flourish.

Facilities for business and growth Cels manages a number of world-class facilities for both R&D and business growth across the region enabling it to provide business, marketing and development support for companies in healthcare and life sciences. It forges innovative connections between high-level academic research and commercial markets.

Cels provides access to state of the art incubator facilities, business support and management advice through our venturing programme.

Cels can also provide start-up organisations with the business support needed to help them grow into successful enterprises. It can put companies in touch with potential sources of grant finance and can continue to support their development by providing facilities support and advice to ensure successful outcomes for the business.

Keeping in touch Cels holds a series of popular workshops that offer advice on specific healthcare topics such as technology translation, public sector engagement, implementing innovation as well as general business advice such as marketing and finance.

Cels can facilitate introductions with key organisations across the region and also invites companies to join Cels’ network HealthConnect, which offers a range of services from exclusive discounts and rewards to expert business and scientific advice.

“Cels plays a significant role in the delivery of the North East region’s plans in healthcare and life sciences”

An extensive network of contacts across North East England spans organisations in the public and private sectors, academics, researchers and clinicians. Cels can put businesses in touch with these specialists, providing them with a wider scope of partnering opportunities. It provides networking opportunities through Cels HealthConnect and can make businesses more attractive to potential partners by providing management advice and business support in whichever area it is needed.

From idea to product If an individual has developed an idea for technology in the healthcare or life sciences arena, Cels can provide the support and information he or she needs to take it to market. We can give the idea the best chance of success by helping to develop a business plan and by providing a range of other services. Researchers are offered the business support necessary to develop an idea, secure funding and ultimately, take the product to market. Facilities such as Cels at Newcastle provide state-of-the-art incubation space, and Cels’ venturing programme can also provide specific management and financial expertise.

Cels has close relationships with a number of key organisations and agencies across the region such as government organisations, business parks and academic institutions and can facilitate introductions with these organisations.

Firm foundation To date Cels has helped hundreds of companies start, grow, and flourish across the North East region. It has enabled these companies to create impact, has supported them in achieving their recruitment targets, and has also provided strategic management, sales and marketing advice.

Cels also works extensively with international teams to stimulate inward investment. This includes working closely with the North of England team based in North America to promote the region and the wealth of opportunities it offers to international organisations.

For further information visit our website

www.celsgroup.com W W W . C E L S G R O U P. C O M 7

H E A LT H C O N N E C T - B E W E L L CONNECTED IN THE REGION

HealthConnect – The network for professionals and organisations working in the healthcare and life sciences sector.

At the start of 2009, as the world slumped deeper into economic recession, networking became an important focus for many businesses trying to ride out the tough times ahead.

This has been clearly evident in the North East with over 400 academics, businesses and clinicians signing up as members of the new HealthConnect network since its launch in June 2009.

Having a large network of contacts can prove to be an effective weapon in these tough economic times and the merger of Cels’ Healthcare Network and BioNEt has created a powerful network for these groups to collaborate.

The healthcare sector is thriving in the North East but can only continue to grow if the industry shares ideas, innovation and best practice. HealthConnect champions this partnership approach, and we have ambitious plans to increase the network to over 500 members in 2010/2011 and add more services to help individuals and businesses achieve their goals.

HealthConnect aims to respond to members’ needs and to be proactive in developing initiatives that will address the challenges of the sector. 2010 will see the creation of a steering committee – a group of independent representatives from each of the network’s subsets – to ensure the network delivers the services its members want.

The representatives will be constituted by the members, for the members, and will be charged with appointing a chair to drive the group forward.

8 C E L S H E A LT H C O N N E C T

The network will also engage with more academic institutions throughout the region.

We are already building solid relationships with the five principal universities across the region. We would like to attract even more academics to create a truly representative network. We will also be working with more NHS organisations across the North East to attract a larger number of clinicians such as doctors in private surgeries and other health practitioners.

The sector in the region is already reaping the benefits of this network with new partnerships forged, stimulation of new product development opportunities and companies accessing previously untapped markets.

Now, more than ever, the North East needs to present a unified and consolidated face in order to remain at the forefront of the sector nationally and internationally.

Kenny Lang, Chief Innovation Officer at Cels said:

“Networking and partnership opportunities are crucial to developing the sector and helping to secure the North East’s reputation as the place to do healthcare business.

The healthcare sector thrives in the North East but can only do so if the industry continues to share ideas, innovation and best practice. HealthConnect champions this partnership approach, and we already

have ambitious plans to increase the network and add more services to help our members achieve their goals.

HealthConnect is just one of the ways Cels is delivering more commercially valuable support for our stakeholder organisations.”

HI G HLI G HT S FO R 2 0 1 0 n A new HealthConnect steering

committee will be created which will be a group of independent representatives from each of the network’s subsets.

n A range of specialist events and

workshops will be organised including IP clinics and events with our key partners such as UKTI. n Our member benefits and services

will be broadened to meet the changing needs of our membership. n We will be increasing our links with

international supply chains to maximise opportunities for our members operating in these overseas markets.

n The fourth Business for Life Awards

will be held on 11 November 2010 which will showcase and recognise the North East’s top companies in the industry.

Benefits and services HealthConnect provides a range of premier support activities and services which are all designed to drive best practice and help our members grow and succeed. Our members are active in assistive technology, health informatics, medical devices, biotechnology and life sciences, social care, health and well being as well as their associated supply chains.

The network brings together healthcare and life sciences professionals and organisations to stimulate translational research, innovation and collaboration as well as commercial opportunities.

Benefits and services include: Members Directory Promote your organisation in our member’s directory, valued at £250, giving you exposure to over 2,500 key contacts in the sector.

Weekly eNewsletter Receive up to date sector news including information on events, business and funding opportunities.

HealthConnect Website Raise your presence online and post your company profile and web link on our website.

Specialist Events Attend a range of informative and interactive events to learn of new developments, exchange knowledge and explore opportunities.

Monthly networking Enjoy complementary refreshments in a relaxed atmosphere, making new contacts and keeping up to date with what’s new in our sector.

Information One stop shop for information. Contact the HealthConnect team for advice and information on current activities within the sector.

HealthConnect aims to do this by: n Creating networking opportunities n Stimulating translational activities n Showcasing the regions talent and expertise n Disseminating sector news n Attracting inward investment n Supporting innovation n Facilitating collaborations n Identifying new business opportunities n Connecting with the sector on a national level n Providing a forum for influencing policy n Sourcing valuable sector information

Business for Life Awards Be part of the North East’s prestigious awards dinner celebrating the achievements of the region’s life science and healthcare industry.

Joining HealthConnect gives you access to a broad range of benefits and services aimed at delivering value to help your business increase its performance and competitiveness.

Marketing and PR Support Receive a marketing health check and advice as well as support in securing press coverage to promote your business.

Be well connected, join HealthConnect now.

To become a member contact us on 0191 215 5025 or email info@celsgroup.com

www.bewellconnected.co.uk

Business-University Interfacing Utilise our expertise in matching businesses with the knowledge-base to promote technology development and leverage commercialisation opportunities.

International Collaboration and Business Development Receive advice and financial assistance for forming trade delegations, attending trade visits and developing collaborative links with overseas companies.

Market Insight Keep up to date with relevant market, technology and IP information in the sector available through our Thomson Database. Receive a free annual market evaluation report.

Jobs in Healthcare Advertise your vacancies on our website and in our eNewsletter free of charge.

Student and Graduate Placement Working closely with the university careers services we assist in matching member companies to talented undergraduate and postgraduate students.

Discounted Services We source exclusive offers on products and services ranging from legal and IP advice to discounted stationery products.

And more... We are constantly looking to add more benefits and services to help our members grow their businesses and expand their opportunities.

W W W . C E L S G R O U P. C O M 9

Influencing Progress - Enabling Connections Enable

Develop

BIA business development an extension to your business development team

Industry leading training and development programmes

Connect Industry leading events

Communicate The voice of UK bioscience

Influence Creating an environment for success

www.bioindustry.org

INFRASTRUCTURE AND I N C U B AT O R F A C I L I T I E S I N NORTH EAST ENGLAND

The growth of the healthcare and life sciences sector requires fit for purpose high quality infrastructure in the form of specialist laboratories, offices, biomanufacturing facilities and incubators.

The North East has a good supply of laboratories and specialist facilities including proteomics labs (NEPAF) and GMP biomanufacturing space. Cels has agreements in place with the Universities of Durham and Newcastle to manage and market the GMP facility and importantly make them accessible to the private sector while at the same time still retaining capacity for academic use.

A focus on Cels at Newcastle Located within Newcastle University’s Medical School and managed by Cels, this facility is a unique micro-incubation facility designed to help start-up healthcare and life science companies grow. The Cels at Newcastle micro-incubator is the first of its kind in North East England and has been specifically designed to provide a vibrant workspace where new business ventures in the life sciences and healthcare sector can be established.

The fully serviced facility comprises seven individual wet laboratory units for start up life science or healthcare companies.

Laboratories are fitted out to a high specification and include both fume cabinet and Class II safety cabinets as standard, in addition to the centralised supply of specialist gases for tissue culture operations. The facility also includes fully furnished office space and a conference room with audio visual facilities.

Through the use of well established networks, Cels aims to promote good practice in incubation by generating synergies between companies within the micro incubator, external businesses and the region’s universities.

This serves to bring together like minded companies and individuals, encouraging the sharing of information and experience as well as intellectual and business resources.

Current Cels at Newcastle tenants: BioTransformations Ltd is aimed at greatly improving the specificity, safety and efficiency of anti-cancer treatment using monoclonal antibodies (Mabs). www.biotransformations.com Demuris is a biotechnology company specialising in the discovery of novel antibacterial agents. A spin out from Newcastle University, Demuris takes exciting new ideas for antibiotic drug screening, and initiates discovery programmes aiming to develop candidate drugs for partnering with pharmaceutical and biotechnology companies. www.demuris.co.uk Genesis Genomics UK Ltd plans to offer a comprehensive suite of scientifically proven skin wellness products and services including sunscreens, antioxidants, DNA-based sun damage testing and monitoring, followed by personalised healthy sun lifestyle programs. www.genesisgenomics.co.uk HB Innovations Ltd is a contract research and development company providing development of in-vitro diagnostic reagents and assays for IVD companies on a global basis. www.hbinnovations.co.uk HB Research is an SME set up to design and develop innovative electrophoresis platforms and diagnostic reagents. HB Research hopes to provide innovative solutions for Gel Electrophoresis and Capillary Electrophoresis, for a range of diagnostic assays.

Selective Antibodies Ltd is a diagnostics company with the prime focus of overcoming key technological problems in the production of high performance point of need systems for small target molecules. www.selectiveantibodies.com

Other infrastructure and incubator facilities: Newcastle Bio-manufacturing Facility Located at the International Centre for Life, the Newcastle Biomanufacturing facility offers clients the very latest equipment and conditions required to handle human stem cells. The facility provides the room space and air handling capabilities that, when combined with the process management requirements of cGMP (current Good Manufacturing Practice), will enable the production of cell therapies for use in human patients. This facility provides an excellent opportunity to build partnerships with internationally recognised stem cell scientists and clinicians. In addition it can offer a strategic route through which clients can establish a UK/ European base for the production of biologics to EU cGMP standards and to access new markets.

New cGMP facility to open at Cramlington This new incubator will offer a complete suite of cGMP equipment for SME tenants and for external clients, including, six follow-on life science units, one clean room unit and one cGMP unit. The complete suite of cGMP equipment already installed in the facility provides an attractive entry point into this expensive area of commercial activity for small to medium sized contract manufacturing companies and also for those CMOs who are in occasional need of spare capacity. This facility provides an attractive route for those companies with projects which are close to clinical trial manufacture.

NEPAF (the North East Proteome Analysis Facility) With its main laboratory located on the campus of Newcastle University and a second laboratory located on the campus of Durham University, the NEPAF facility provides industrial and academic sectors with access to cutting edge equipment and support for the analysis of proteomics for the likes of drug discovery and diagnosis of disease.

For further information contact Kenny Lang, Chief Innovation Officer at Cels on 0191 215 5519 or email kenny.lang@celsgroup.com

W W W . C E L S G R O U P. C O M 1 1

dis.tinc.tive [di-stingk-tiv] - adjective 1. serving to distinguish; characteristic; distinguishing: the distinctive stripes of the zebra.

2. having a special quality, style, attractiveness, etc.; notable.

- distinctively a. distinctiveness n.

8th Floor | Aidan House | Sunderland Road | Gateshead | NE8 3HU T: 0191 478 83 00 | E: enquiries@distinctivegroup.co.uk

I N T E R N AT I O N A L I N V E S T M E N T IN THE NORTH EAST

Dr Kenny Lang , Chief Innovation Officer, Cels signs the Joint Venture Agreement with Dr Yunlong Hu between Cels Business Services Ltd and Signalway Antibody Company UK Ltd for the formation of the new company ArrayMed Ltd at the 2009 International technology Transfer Conference in Nanjing.

North East England has a successful and thriving healthcare and life science economy, featuring global pharmaceutical companies such as Sanofi-Aventis, GSK and MSD, world leaders in biologics manufacturing and rich sub-clusters of companies in fields such as medical devices, assistive technology and health informatics.

Our knowledge base has much to offer in oncology, ageing and health, genetics, plant biotechnology, stem cells and regenerative medicine, infectious diseases, biologics, cell biology, diagnostics and medical devices. We have welcomed significant life science and nanotechnology investments from Japan, China, India and North America.

Universities, support agencies and investment organisations combine to provide companies with advantageous business conditions and a knowledge base for profitable growth. The region boasts five regional universities with 17 departments rated 4* for their research capabilities in healthcare and life sciences.

There are strong central support networks for healthcare R&D, inter-company interaction, supply chain initiatives and peer-group networking. Companies benefit from a dynamic, forward-looking economy with pro-business attitudes, low operating costs, a flexible, skilled and intelligent workforce, strong research support, competitive financial incentives and a range of high-tech offices and incubators, science and business parks.

For further information contact Kenny Lang, Chief Innovation Officer of Cels, on 0191 215 5025 or kenny.lang@celsgroup.com

A FOCUS ON MEDICAL DEVICES n The North East of England has

a strong product research and development strength in medical device technologies and a willingness to engage with the private sector.

n There is a complete business

support supply chain for all forms of medical device technologies including strength in sales & distribution. n There is the expertise and ability in

place to support the full field testing of remote POC diagnostics. n The region has strength in product

testing and trialing of new medical device technologies. n There is a well characterised and

accessible static patient population to trial medical device technologies.

A FOCUS ON DRUG DISCOVERY n The North East of England has world-

renowned translational research into drug discovery and development within the region’s five universities. n There is a complete business

support supply chain for drug discovery activities in the region. n The region demonstrates significant

expertise in translational ‘bench-tobedside’ stem cell research, neurology, ageing, oncology, human genetics and toxicology.

n The Clinical Trials capabilities

are housed within and between the University of Newcastle and the National Health Service providing access to a large pool of patients.

North East Links with China

North East England has signed a special business arrangement with Shanghai and Jiangsu - the two major business powerhouses in China. The signing of these Memorandums of Understanding (MOU) will help businesses in the UK and China engage with each other more easily. More joint research with companies and universities in these two areas are also encouraged.

On 3 September 2009, Cels signed an MOU with Nanjing Pharmaceutical Contract Research Organisation (NCRO).

Representatives from One North East and Jiangsu Department of Science and Technology also attended the signing ceremony.

According to the MOU, Cels and NCRO will collaborate closely in bio-pharmaceutical research and development. The two sides plan to set up a Sino-British Life Science Innovation Centre (Nanjing). In addition, both parties also agree to set up a management committee that aims to coordinate the development plan and set up targets and key work for the future.

In 2010, the two parties plan to accomplish collaboration in three stages: n Information exchange n Talent exchange n Implementation of a Soft Landing Scheme between China and the UK. The singing of the MOU will create more business opportunities for pharmaceutical research organisations and commercial companies in the region.

W W W . C E L S G R O U P. C O M 1 3

N E PA F - Y O U R PA R T N E R IN PROTEOMICS

Proteomics expertise to accelerate life science research and development.

NEPAF (the North East Proteome Analysis Facility) works with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally, providing them with access to leading expertise and equipment for the study of proteins.

Over 172,000 people are employed in the healthcare industry in the North East, producing an annual turnover of over £8 billion. Through the NEPAF project Cels is investing in emerging technology and placing the region on the world stage for healthcare research excellence.

Achievements in 2009: n NEPAF secured its first large scale commercial contract with Biosignatures as well as finalising agreement to provide analytical support services to Protein Forest (now Cell Bioscience) and Pressure Biosciences Inc. n New services were launched including quantitative proteomics and launched a MALDI-TOF based rapid biotyping services n NEPAF achieved ISO9001 accreditation n The team expanded with the appointment of a business development manager to promote NEPAF to life science companies across the UK. A unique service for life sciences The facility covers all aspects of proteomics, giving clients access to expertise in the use of proteomics for drug discovery, development and manufacture and in the diagnosis and monitoring of disease. Services include: n Study and experimental design n Proteome analysis

1 4 C E L S H E A LT H C O N N E C T

n Collaborative research projects with

academic institutions and commercial companies n Analysis and reporting of data n Independent validation support for methods and data from external laboratories n Training in proteomics theory, methods and applications.

With its main laboratory located on the campus of Newcastle University and a second laboratory located on the campus of Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund.

Dr Glen Kemp, NEPAF Programme Manager, comments: “The UK’s biotechnology sector is growing and in order for this growth to continue, we need to provide state-of-theart facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies and research groups of all sizes carrying out significant and, in some cases, groundbreaking research and development using proteomics that will secure the reputation of the North East as the place to do biotechnology business.”

State of the art technologies and equipment NEPAF offers state of the art technology to enable first class research methods including protein extraction, using one of the first pressure cycling homogenisers in the UK, protein separation using 2- Dimensional Polyacrylamide Gel Electrophoresis (2D-PAGE) and multidimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of analytical techniques, including six different mass spectrometers.

These instruments provide capabilities for biomarker discovery, signal transduction pathway analysis, protein expression analysis, protein identification, quantification and characterisation.

NEPAF’s strengths lie in the application of LC-MC and LCMS/ MS methods in the identification, quantification and characterisation of proteins. Analysis of the resulting three-dimensional datasets using peak recognition and alignment software generates data for subsequent examination.

Teamwork with individual care NEPAF has a dedicated team of six scientists with over 60 years of experience in the fields of protein chemistry, bioanalytical chemistry, clinical chemistry and proteomics.

The team has a growing track record with a number of regional and national pharmaceutical companies NEPAF’s capabilities are now being launched into the wider bioscience network of contract research and biotechnology organisations.

The NEPAF team has a sound commercial understanding and recognises the importance of robust quality control procedures. They can ensure that organisations generate reliable and relevant data to enable product development and commercialisation.

Achim Treumann, Scientific Manager of NEPAF says: “Our aim at NEPAF is to use state of the art technology to provide solutions for real world biochemical problems.

Our ability to help customers with the design of the right experiment, together with our advanced data generation and data analysis tools will open up proteomics to a wide audience in academic and

commercial research. The level of validation of experimental data generated in the NEPAF lab ensures clients obtain reliable results. Our scientists’ communication skills ensure that they are understandable.”

Every NEPAF project is assigned a dedicated project manager who acts as the single point of contact and ensures that progress is made in accordance with mutually agreed milestones.

Outside the traditional biotech and pharmaceutical markets NEPAF also makes novel applications of proteomics available to industries such as the food and beverage sector and quality testing laboratories.

Supporting educational establishments NEPAF provides proteomics services to the academic research sector, assisting both groups and individuals in all stages of a study from planning and preparation of grant applications through to co-authorship of research papers. The facility supports higher education establishments on a regional, national and international level on projects in the fields of human, animal, microbial and plant biochemistry.

“NEPAF provide a professional service and support, and have been instrumental in the identification of novel molecules involved in cell differentiation”.

Stefan Pzyborski, Director, CSO and Scientific Founder of ReInnervate

In addition to providing commercial analysis services, one of the goals of NEPAF is to work with regional, national and international companies to help them develop the next generation of products and tools for protein analysis, drug discovery and development. One example of this is the recently announced strategic relationship with Prozomix, a company which develops, produces and supplies a large, diverse and rapidly expanding range of highly purified recombinant enzymes and proteins. In addition to providing Prozomix with advanced analytical support services for its current products, NEPAF is helping Prozomix develop a portfolio of next generation recombinant proteins for various applications, including the diagnosis and monitoring of human disease.

Working together, scientists from NEPAF and Prozomix have identified innovative areas for product diversification and development, including a project to develop a range of new standards for quantitative proteomics, based on SILReP (Stable Isotope Labeling of Recombinant Proteins) technology.

The project, designed to exploit core competencies of each partner, is on track to generate prototype products by mid 2009.

Newcastle University, Durham University, the Institute for Ageing and Health and the Institute of Human Genetics are just some of the research groups that have collaborated with NEPAF. By engaging with NEPAF at an early stage of the planning process, academic researchers can benefit from the team’s advice in identifying the most appropriate analytical approaches to use in a research project.

The NEPAF team will then assist in the development of an appropriate experimental design to ensure reliable and robust data.

CASE ST UDY

Further information on NEPAF visit

www.nepaf.com

www.prozomix.com

W W W . C E L S G R O U P. C O M 1 5

Proteomics expertise to accelerate life science research and development.

NEPAF (the North East Proteome Analysis Facility) works with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally, providing them with access to leading expertise and equipment for the study of proteins.

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ÀFDQW SUHVHQFH LQ DOO VXE UHJLRQV RI 1RUWK (DVW (QJODQG 1RUWKXPEHUODQG 7\QH :HDU 'XUKDP DQG 7HVV 9DOOH\ DQG WKH FRPELQHG HFRQRPLF SRZHU RI 1(3,& FRPSDQLHV DQG WKHLU LPSRUWDQFH WR WKH UHJLRQ DQG WKH 8. FDQQRW EH RYHU HPSKDVLVHG .H\ VHFWRU IDFWV LQFOXGH

‡ *HQHUDWHV … EQ RI WKH UHJLRQV *'3 ‡ HPSOR\HG GLUHFWO\ ‡ ,PSDFWLQJ RQ VXSSO\ FKDLQ MREV ‡ +RPH WR RI WKH 8.·V SKDUPDFHXWLFDO LQGXVWU\ DQG RI 8. SHWURFKHPLFDO LQGXVWU\

iPDMRU HFRQRPLF FOXVWHUj %HQHÀWV 0HPEHU FRPSDQLHV ÀQG EHQHÀW IURP LQGXVWU\ OHG OHDGHUVKLS DQG FR RUGLQDWLRQ RI DFWLYLWLHV ZKLFK KDYH PXWXDO EHQHÀW 7KH VHFUHW WR 1(3,&·V VXFFHVV LV WKDW WRS LQGXVWULDOLVWV IURP DOO VXE VHFWRUV LQ WKH UHJLRQ IRUP WKH 1(3,& /HDGHUVKLS 7HDP ZKRVH NH\ DFWLYLW\ LV WR HQVXUH WKH JURZWK VWUDWHJ\ UHDFKHV LWV WDUJHWV 6SHFLÀF PHPEHU EHQHÀWV LQFOXGH ‡ 1HWZRUNLQJ RSSRUWXQLWLHV WKURXJK RXU UHJXODU EXVLQHVV DQG VRFLDO PHHWLQJV ‡ ,QWHUQDWLRQDO 7UDGH 1HZ %XVLQHVV 2SSRUWXQLWLHV DQG 6XSSO\ &KDLQ &RQQHFWLRQV ‡ 3XEOLFLVLQJ \RXU EXVLQHVV DQG WKH UHJLRQV FDSDELOLWLHV RQ D JOREDO OHYHO WKURXJK WKH 1(3,& ZHEVLWH 1(3,& 'LUHFWRU\ EL PRQWKO\ )RFDO 3RLQW PDJD]LQH DORQJ ZLWK D QXPEHU RI EHVSRNH PDUNHWLQJ EURFKXUHV ‡ 6XSSRUW IRU \RXU 5HJLRQDO ,QYHVWPHQWV ZLWK 7HFKQLFDO )XQGLQJ DGYLFH ‡ ,QFUHDVHG SURÀWDELOLW\ WKURXJK (QHUJ\ 5HVRXUFH (IÀFLHQF\ DQG 3URGXFWLYLW\ 3URJUDPPHV ‡ ,PSDFWLQJ RQ 6NLOOV (GXFDWLRQ DQG 6WDNHKROGHUV ‡ $FFHVV WR :RUOG &ODVV 7HFKQRORJ\ ‡ 2SSRUWXQLW\ WR MRLQ WKH 1(3,& %X\LQJ *URXS PHPEHUV VDYHG D WRWDO RI … LQ WKH ÀUVW \HDU RI PHPEHUVKLS

iLQGXVWU\ OHG OHDGHUVKLSj

µ

0HPEHUVKLS

,I \RXU FRPSDQ\ LV SDUW RI WKH 3KDUPDFHXWLFDO &KHPLFDO 6SHFLDOLW\ RU %LRWHFKQRORJ\ VHFWRU DQG EDVHG LQ WKH 1RUWK (DVW RI (QJODQG RU LQYROYHG LQ WKH VXSSO\ FKDLQ WR WKHVH FRPSDQLHV \RXU RUJDQLVDWLRQ FDQ EHQHÀW DQG EHFRPH D PHPEHU 1(3,& LV D FRPSDQ\ OLPLWHG E\ JXDUDQWHH DQG LV D QRW IRU SURÀW RUJDQLVDWLRQ

µ

iFRPELQHG HFRQRPLF SRZHUj

1(3,& KDYH SURYLGHG 15* ZLWK D QXPEHU RI QHWZRUNLQJ RSSRUWXQLWLHV DW HYHQWV GLQQHUV DQG JROI GD\V 7KLV KDV KHOSHG UDLVH WKH SURÀOH RI RXU EXVLQHVV DQG LQ SDUWLFXODU RXU VFLHQWLÀF DQG HQJLQHHULQJ UHFUXLWPHQW GLYLVLRQV $V D UHVXOW RI WKLV ZH·YH UHFUXLWHG ÀYH QHZ FRQVXOWDQWV LQWR RXU VFLHQWLÀF WHDP :H ORRN IRUZDUG WR FRQWLQXLQJ RXU UHODWLRQVKLS ZLWK 1(3,& DV D NH\ SDUW RI WKH SURFHVVLQJ LQGXVWU\ VXSSO\ FKDLQ LQ 1RUWK (DVW (QJODQG µ Dylan Christie, Director, NRG Professional Services Group

ZZZ QHSLF FR XN

C B S L - TA K I N G Y O U R SCIENCE TO MARKET

Mike Nicholds, Managing Director of Cels Business Services Ltd (CBSL), reflects on a busy year in the healthcare and life sciences sector in the region – and looks ahead to the challenges and opportunities in 2010.

It has been an unprecedented year of growth for CBSL, both in its activities and its geographic reach. It appears that the North East’s appetite for innovation has not abated despite the challenging times that are facing everyone in the region.

The CBSL team at Cels is delivering more services than ever, helping to commercialise ideas, encourage growth and provide added value to both the public and private sectors.

CBSL, the wholly owned subsidiary of Cels, provides consultancy services to support start-up and existing companies, universities and public sector clients. As specialists in healthcare and life sciences, we have an excellent track record of delivering consultancy services to clients in the private and public sector based on the wealth of expertise in the commercialisation of life science and healthcare technology.

The CBSL team of consultants working across the north of England and Scotland, draws on over 100 years of collective experience in a variety of sectors including industry, academia and the NHS in areas of innovation and commercialisation, project evaluation, economic development and technology transfer.

CBSL won the tender with the Department for Business Innovation and Skills (BIS) to create a new National database for bioscience and health technology companies. During

1 8 C E L S H E A LT H C O N N E C T

November 2009 the team celebrated a key milestone in the project when the report was launched by Lord Drayson and the Department for Business, Innovation and Skills (BIS). The report has been well received within the industry and addresses the need for better data to allow policy makers to fully understand the scope of the medical biotechnology sector in the UK. The CBSL team will be providing annual commentaries on the sector and will be adding to and amending the database every year. This will allow BIS to report trends in medical biotechnology and track the progress of the sector over the next two years.

We’re delighted to have been instrumental in this UK-wide project as we continue to expand the geography of our activities. CBSL consultants are now working across the North East, Yorkshire and Scotland, delivering more projects to help put the north of the UK firmly on the map in healthcare and life sciences.

The team is currently working with Yorkshire Forward on a two phase study of the biomedical cluster, researching the companies and individuals operating within the sector to find out if there is a need for a network in Yorkshire. The RDA approached CBSL as a result of our work on the BIS database and has recently appointed us to carry out the implementation stage of the project, following positive feedback on the value of a network.

The CBSL team is also taking advantage of business opportunities north of the border. Scottish Enterprise and the Scottish government have invested widely in the region over the past 10 years securing its position as one of the top clusters for healthcare and life sciences in the UK. We made the

move into Scotland as a direct response to this investment and are already reaping the benefits.

The CBSL team has already carried out work for a leading Scottish university and, in 2010, will focus on building relationships and networking with the other academic institutions across Scotland. There is a lot of commercialisation activity coming out of the Universities and this year will see the launch of CBSL’s ‘Transforming Ideas’ in Scotland, a training package aimed at academic entrepreneurs to help them understand commercialisation processes.

CBSL finished 2009 on a high by being appointed to two panels of consultants for assisting Scottish companies. The new CBSL consultant in Scotland is tasked with handling these contracts, by providing advice to start ups in life sciences (including market and technology assessments, business plans and commercialisation activities) and by working with established companies on growth strategies.

In the North East, CBSL’s involvement with local initiatives continues to grow. The team is currently working on eight commercialisation projects with Newcastle University providing market analysis, compliance advice and benchmarking on projects ranging from tissue banking to brain electrodes.

All in all, it’s a busy year ahead for our growing team and we will continue to expand our skills and our networks to ensure we meet the needs of our clients in 2010. For further information contact Mike Nicholds, Managing Director of CBSL on 0191 215 5025 or mike. nicholds@celsgroup.com

Commercialisation of Science CBSL has specific expertise in the complex process involved with scoping, incubating and growing spin-outs from universities. CBSL has developed a suite of capabilities and expertise that has been demonstrated over the life cycle from initial scientific invention, through IP and due diligence to proof of concept, company formation and development. CBSL has in-depth experience in fund-raising, venture capital investment, business planning and interim management.

This phase of any commercialisation process is often the most important. If done correctly, critical time and resources can be saved by identifying the high potential opportunities, key milestones and risks.

This stage includes scoping the technology capability, IP landscape and risks, market sector applicability and size, competition, risks and milestones to commercialisation and regulatory hurdles. CBSL has in-depth industrial experience in the rapid assessment of complex technologies and markets.

Through this complex process of commercialising science, CBSL consultants have worked flexibly with academic founders, university technology transfer professionals and investors to accelerate spin-outs to commercialisation and value realisation.

From our extensive portfolio of work, we have demonstrated the ability to ANALYSE technology and markets, INNOVATE and develop pathways to commercialisation and to TRANSFORM organisations’ prospects to generate value.

INCUBATE Idea realisation and business proposition n Customer-driven development n Proof of concept - proving the concept meets market needs n Accessing funds - identifying funds that can develop the technology n Technology development - defining the pathway to product

We have developed an in-house model which maps the pathway to the development of a successful early stage company. The approach is tailored to match clients’ internal processes, so that a synergistic and efficient process can be applied at a strategic level to manage a pipeline of opportunities.

SCOPE Scoping the potential of your idea n Strategic analysis of research capabilities n Technology feasibility - applications and risks n Competition analysis - determining opportunities and threats n Market analysis - assessing the market need

The potential of any scientific discovery or idea to realise value to society requires a combination of technology development framed by an understanding of the unmet market needs. This stage includes direct customer engagement to assess market potential and providing direct information on customers’ desired performance, competitive products and early adopters for prototype products. The careful design and implementation of proof of concept studies is a critical part of the pathway of commercialisation. The correct balance between demonstrating the technology performance and how this relates to market needs must be planned into a study to ensure timeliness and minimise cost.

The accessing of funds for market-focused technology development is often a limiting

factor. We have experience in assisting individuals and academic groups to secure these competitive funds. Incubation of technology-based commercial opportunities is often a creative process, at the end of which an outline business proposition emerges.

Developing science into market-ready and market-valued technology is a key skill provided by CBSL. GROW Business development and commercial reality n Company operational set up - forming your business n Marketing - taking your product to market n Business planning - turning your ideas into commercial reality n Fund raising - identifying growth funds n Interim management and leadership providing the commercial expertise If the route to commercialisation is via a startup then the ability to access services and expertise normally found in larger companies becomes an issue. We have developed a suite of services and innovative approaches which covers operational start-up through marketing to venture capital and other fundraising.

This model has already been pioneered by CBSL with North East university spin-outs.

Academic entrepreneurs have been teamed with sector experienced commercial experts to lead in the development of the business plan, raising external venture financing and, where appropriate, to take interim executive roles within the new company.

Contact us on 0191 215 5025 now to find out how we can help you commercialise your science or visit www.cbsl-uk.com

W W W . C E L S G R O U P. C O M 1 9

CBSL - CASE STUDIES

NATIONAL BIOSCIENCE DATABASE

BIOTOOLOMICS

DURHAM UNIVERSITY

The Department for Business Innovation and Skills (BIS) commissioned CBSL in early 2009 to develop the methodology for creating a new national database of bioscience and health technology companies across the UK.

Chad Zhang (PhD), founder and Managing Director of BioToolomics, has extensive academic and industrial experience of chromatography systems used in the purification of biopharmaceuticals. When he decided to set up his company to exploit his novel ideas, he commissioned CBSL to provide expert guidance and support.

Durham University engaged CBSL to assist with the commercial development of their dermal stem cell science. Using CBSL’s Technology Mapping and Analysis techniques, we benchmarked Durham’s science to be both world leading and having commercial potential.

CBSL developed a plan for collating the necessary new data, created a rational segmentation protocol for the data and following a detailed analysis of findings, wrote a comprehensive summary for BIS on the relevant UK industry segments.

We developed a novel segmentation scheme which will allow us to rapidly and accurately evaluate shifts in segment profiles and report annually to BIS and other government departments on the most important trends and factors that are affecting this sector.

During the course of the project, CBSL worked closely with three agencies; BIS, the UKTI and the Department for Health, to build this one of a kind database. We also collaborated with a number of regional and national data partners and with a range of external data providers to populate the new national database. CBSL built a range of reporting functionalities into the database which can be used to interrogate the data and deliver a detailed analysis of sector changes. CBSL is also responsible for annual updates to database as well as training appropriate personnel to use it.

Through this project we have demonstrated an advanced ability to access and compile key data through close collaboration with a range of partners and industry bodies. In addition, CBSL has demonstrated unique data interpretation and analysis skills delivering insights that support the formulation of regional and national economic and investment policy.

2 0 C E L S H E A LT H C O N N E C T

CBSL has supported Dr Zhang with intellectual property management advice through to business planning and fund raising. Subsequently CBSL has leveraged finance from both public and private sources.

Initially this was in the form of grants and proof of concept funds required to prove and exemplify his technology. Latterly it has been to access significant funds to facilitate major product launches. In addition, CBSL has provided access to specialist design services to further enhance his products.

Working with Dr Zhang, CBSL identified the routes to market to successfully exploit his novel technology. We have also enhanced Biotoolomics’ business planning processes so that their ideas are captured in a way that is attractive to investors.

Dr Zhang is an accomplished scientist with extensive commercial experience and CBSL was able to work with him to add value to his unique business proposition.

The CBSL team has extensive expertise in assisting start up companies. This practical assistance includes writing and reviewing business plans, assessing funding and grant applications and raising public and private early stage finance.

CBSL has extensive knowledge and connectivity within the bioprocessing sector. Using these skills, CBSL assisted Biotoolomics to successfully position their products in the market place and attract new customers.

CBSL established freedom to operate by simplifying a complex patent ownership situation. We then created a consortium to translate this into technology for exploitation.

The consortium comprised Avecia Biologics for their bioprocessing expertise and Smith & Nephew for their expertise in wound healing products and tissue engineering.

Having established the partners, CBSL successfully attracted £1.0m of funding from Industry and the Technology Strategy Board to fund this project. The project involves stem cell bioprocess development, leading to therapeutic applications, notably for wound healing. CBSL is playing an on-going role in terms of technology consultancy and project management.

CBSL has the expertise and methodology to undertake technology audits of research institutions to identify world class science and commercial opportunities. We use Technology Mapping to identify intellectual property and assess its strength and coverage by global comparison. We then undertake Technology Analysis in order to assess the value and commercial potential of intellectual property.

CBSL has extensive knowledge and connectivity in the UK industrial life sciences sector. This enables us to broker effective collaborations between academic and industrial partners. The CBSL team has expertise in bioprocess development and product development which has been highly relevant to this project.

The highest quality service in custom-made peptides and antibodies Celebrating 30 years in 2010, as the world’s second-oldest peptide manufacturer, Cambridge Research Biochemicals (CRB) combines a progressive scientific approach with a thorough commercial instinct.

Customers are at the heart of our business. Specialising in the chemical synthesis of peptides and polyclonal antibodies, we provide a highly focused, highly personal level of service. With long-standing relations with some of the world’s largest pharmaceutical companies, we provide individual, not off-the-shelf solutions.

Jointly owned by Emily Humphrys and Alison White – scientists with commercial backgrounds – our company is keen to build on its success and experience with new strategic partnerships. We look for small, specialist biochemical businesses and research institutes whose work complements ours and whom we can help grow and expand.

What we offer: Peptide synthesis

Fluorescent dyes

Tailored products and services

Antibody production

PNA synthesis

Partnering opportunities

Dye and Radio-labelling

Increased market exposure

High standards Outstanding customer service Operational excellence

Cambridge Research Biochemicals

10 Belasis Court, Belasis Hall Technology Park, Billingham, Cleveland TS23 4AZ United Kingdom www.crbdiscovery.com T +44 (0)1642 567180 F +44 (0)1642 567181 E enquiries@crbdiscovery.com

DRIVING THE GROWTH OF ENABLING TECHNOLOGIES I N R E G E N E R AT I V E M E D I C I N E

RegeNer8 is a virtual research centre established by N8, a partnership between the North’s eight research-intensive universities to promote scientific, social and economic development in the North of England.

In 2009 regeNer8 launched a new initiative aimed at encouraging collaboration between the sector’s academics, clinicians and industry professionals. The Translational Regenerative Medicine Award was announced at a special event in October attended by some of the region’s leading clinicians.

The Award is also aimed at generating innovative solutions to unmet clinical needs in regenerative medicine and to help boost the economy in the North of England.

At the event, regeNer8 members were presented with three clinical challenges, which they then had the opportunity to discuss with potential industry partners through a series of facilitated workshops. The members then formed consortia with other regenerative medicine experts from academia and industry to develop a project proposal which addressed the clinical need, competing for a share of significant funding.

The winning projects were announced in November 2009 at regeNer8’s second anniversary meeting. The two successful teams received funding to carry out projects on the maintenance of cells for optimal transplantation and promoting reinnervation.

Following the huge success of the award, regeNer8 will be launching an Industry Challenge Programme early this year which will replicate the clinical challenge model but this time will focus more closely on industry needs.

The Industry Challenge Programme will focus predominantly on tools and techniques that are nearing deployment either in clinical practice, R&D or industrial production.

Leading national and international experts will be consulted to create a priority list of the industry challenges related to stem cell research. In addition, N8 academics and clinicians, who are strongly associated with a theme or challenge, will also be encouraged to meet with industry.

RegeNer8 plans to hold four ‘Ideas Factory’ meetings, which will ask the regeNer8 Industry Group to champion the tools and technologies challenges and address the key themes at the event.

The programme will hold professionally facilitated workshop sessions to help solve the challenges being championed. Regener8 intends to facilitate the presentation of bids for funding to various National bodies.

“regeNer8’s role is to stimulate collaboration between the sector’s academics, clinicians and industry professionals. These programmes are an opportunity to capitalise on the fantastic work that is going on in the north of England, provide innovative solutions to unmet medical needs in the field of regenerative medicine and provide a boost to the local economy.”

Professor John Fisher, regeNer8 Centre Director

ABOUT REGENER8 Established by N8 through the Northern Way initiative to promote scientific, social and economic development in the North of England, regeNer8 is a virtual centre that brings together the work of the North of England’s top scientists to advance and accelerate the development of regenerative medicine therapies and bring them through clinic to market.

Regenerative medicine aims to replace or repair diseased or damaged body parts. It is a highly multidisciplinary area incorporating aspects of engineering, cell biology and materials science and encompasses stem cell therapy, tissue engineering, regenerative drugs and devices.

Members of regeNer8 include scientists within industry and academia, and clinicians who work collaboratively in regenerative medicine. regeNer8 is directed by Prof.

John Fisher at the University of Leeds and is managed by Newcastle based CBSL and BITECIC in Leeds.

For further information or to become a member visit www.regener8.ac.uk

W W W . C E L S G R O U P. C O M 2 3

BUSINESS FOR LIFE AWARDS 2009

Celebrating the achievements of North East England’s healthcare industry A region-wide hunt for the best talent in healthcare and life sciences resulted in a record number of entries for the Business for Life Awards which were held late November 2009.

Seven companies from across the region topped the bill at the Business for Life Awards, which brought together more than 340 of the region’s key players in the healthcare and life sciences community.

The achievements of the sector’s leading companies were recognised in categories including outstanding growth, partnership with the NHS, export, start-up and innovation. New categories for 2009 included the Environment Award, sponsored by Grant Thornton, the HealthConnect Award, sponsored

by NRG and the Technology Award, sponsored by KITE Innovation.

Vicki Gilman, managing director of Neural Pathways (UK) Ltd walked away with the coveted HealthConnect Award, sponsored by NRG, which celebrates an individual’s excellence in the sector. Vicki set up Neural Pathways to help people with complex neurological conditions through collaborative rehabilitation therapies. The company has doubled in size during the last year due to the hard work of Vicki and her team.

This year’s awards received a record number of entries demonstrating that

2 4 C E L S H E A LT H C O N N E C T

despite economic conditions, the sector is still thriving in the region. The Start-Up Award, sponsored by Marks & Clerk LLP, received an impressive number of entries whilst the Innovation Award, sponsored

by Newcastle Science City, was the most subscribed category accounting for nearly a fifth of all entries. Two of the categories were so fiercely contested that the judges also chose a Highly Commended company.

The Partnership with the NHS Award, sponsored by Newcastle upon Tyne NHS Hospitals Foundation Trust, demonstrated once again the fantastic collaborations between industry and the clinical markets in the region.

TV presenter Wendy Gibson hosted the awards ceremony, with speeches from Cels non-executive director and Vice Chancellor and Warden of Durham University Professor Chris Higgins and CEO Mike Asher. Dr Phil Hammond, comedian, GP and commentator on health issues was the guest speaker.

Winners from five of the award categories have been automatically be entered into the Medilink UK National Awards, which recognises the UK’s most innovative healthcare companies. One of the 2008 regional winners, Blyth-based Tynetec, tasted success at national level walking away with top honours in the outstanding growth category.

Mike Asher, CEO of Cels, commented on the 2009 awards: “We were delighted by the high standard of entries from across the region, particularly during this period of economic unrest. The North East is rich with healthcare and life sciences companies that are doing exciting work across a wide range of fields and they all deserve to be recognised.”

“Cels’ Business for Life Awards is an opportunity to highlight the great work that is taking place in our region and to recognise the teams that are making it happen. It’s important that the region is at the forefront of healthcare and life sciences in the UK to ensure that we are well equipped to compete globally.”

The Business for Life Awards, now in their third year, celebrate excellence in the North East’s healthcare industry, which contributes £8 billion to the region’s economy. They recognise the outstanding achievements of the 172,000 people who are employed in the sector in the region whilst cultivating future business success.

Environment Award

The Environment Award recognises organisations that have demonstrated environmental commitment and improvement. Organisations had to demonstrate that they had recognised the importance of environmental excellence, innovation and leadership.

FINALISTS Merck Sharp & Dohme (MSD) MSD Cramlington has implemented a number of successful ‘Champions for the Environment’ projects resulting in excellent employee engagement and community partnering. These have included establishing an environmental playground for children with special needs at East Hartford School and creating a sensory garden at the St John Ambulance Ashington Community Care Centre.

Piramal Healthcare Piramal is reducing its burden on the environment by addressing waste and recycling opportunities at its Morpeth site. Since 2006, waste production on the site has reduced by over 300 tonnes per year and the team has also increased its recycling and recovery rate from 75% to nearly 90%.

Regional Medical Physics Department (NHS) Regional Medical Physics Department (NHS) has developed a mercury-free greenlight 300 for blood pressure measurement. It provides clinicians with a device that is just as accurate as a normal mercury model but with additional features to improve the measurement technique, achieve more accurate results and avoid the possibility of mercury contamination.

WINNERS Merck Sharp & Dohme (MSD) Regional Medical Physics Department (NHS) SPONSOR Grant Thornton As a leading financial and business advisor Grant Thornton UK LLP has offices in 30 locations nationwide and more then 25,000 individual and 15,000 corporate clients. A member of Grant Thornton International and led by managing partner Jonathan Riley, the firm employs over 250 staff in Yorkshire and in the North East, and advises clients across the region.

“We are truly proud of the work that we do within the local community, particularly working with schools and community groups on science education and environmental projects. It really gives staff a sense of achievement, we are delighted to have been recognised for our work and I’m thrilled to accept this award on behalf of all MSD Cramlington employees involved in our community programme.”

Joanne Hay, Lean Six Sigma Facilitator, MSD

www.grant-thornton.co.uk

W W W . C E L S G R O U P. C O M 2 5

Export Achievement Award

Innovation Award

The Export Achievement Award recognises organisations that have maximised opportunities to exploit and develop new market and/or outstanding performance in other areas of international trade. Organisations had to demonstrate substantial growth in overseas earnings and commercial success, to levels that are outstanding for the goods or services concerned and for the size of the organisation’s operations.

FINALISTS Cambridge Research Biochemicals Cambridge Research Biochemicals expanded its exports in the USA and Europe by 25% from 2008 to 2009. As well as providing custom generated antibodies to scientists around the world, the company acts as UK distributor for other companies offerings in PNA, radio-synthesis, monoclonal antibody production and fluorescent dyes.

Hart Biologicals Ltd Hart Biologicals, a manufacturer and supplier of specialist blood coagulation testing systems, has increased its export sales by an impressive 73% over the past year, more than doubling its original target of 30%. The company is now trading extensively with the USA, Europe and Asia and has an ambition to secure contracts in India.

2 6 C E L S H E A LT H C O N N E C T

Immunodiagnostic Systems Ltd (IDS) IDS, which develops innovative assays for use in clinical and research laboratories, has increased its export sales by 67% over the last year. Efforts have been focused on enhancing sales and distribution networks in countries where they already trade including Canada, Australia, China, Italy and the Netherlands.

WINNER Hart Biologicals Ltd SPONSOR UK Trade & Investment UK Trade & Investment is the Government organisation that helps UK-based companies succeed in international markets. Their range of expert services are tailored to the needs of individual businesses to maximise their international success. UK Trade & Investment provide companies with market information, business contacts and opportunities to help them grow overseas. www.uktradeinvest.gov.uk

“This award acknowledges the huge effort from administration, sales, manufacturing, QC, development, and the rest of the team. We are a small but very strong team at Hart Biologicals and I would like to thank them for all their hard work.”

Malcolm Pattison, Production Manager of Hart Biologicals

HealthConnect Award

Outstanding Growth Award

The HealthConnect Award recognises excellence in an individual who is helping to put the North East on the world map as one of the leading regions for healthcare and life science services.

Individuals had to demonstrate that they had excelled in their field and have been involved in translating the region’s worldclass research into cutting edge products and services. These people are integral to the continuing growth of the scientific and economic life of the region and the HealthConnect Award offers a unique way to reward their efforts.

FINALISTS Louise Flintoff – Leica Biosystems As theranostics product manager at Leica Microsystems, Louise is responsible for products from their conception, through development and launch and for the long term management of the technology. She has developed a comprehensive staff and dealer training programme, a customer facing e-learning programme and has achieved a successful uptake of the product in key regions of Europe.

Vicki Gilman – Neural Pathways (UK) Ltd Vicki Gilman launched Neural Pathways to help people with complex neurological conditions through collaborative rehabilitation therapies. She believes that the best results occur if teams of professionals worked together more cohesively to address a patient’s specific needs. The company has doubled in size

during the last year due to the hard work of Vicki and her team.

Professor Stefan Przyborski – Reinnervate Ltd Professor Przyborski is the founder, director and chief scientific officer of Reinnervate Limited which has attracted investment of over £3m to date. An enterprising academic and entrepreneur, he regularly publishes and speaks on national and international platforms about his work.

WINNER Vicki Gilman – Neural Pathways (UK) Ltd SPONSOR NRG NRG are the North East’s largest recruitment business. NRG is a national recruitment solutions company delivering bespoke recruitment services for over thirty years. NRG set out to provide quality recruitment services to both the private and public sectors. NRG are a multidiscipline business of specialist teams dealing with levels of recruitment from industrial and clerical posts to specialist professional and executive roles.

“This new award recognises achievement by an outstanding individual in the life sciences and healthcare sector, which ties in very closely with our ethos of matching outstanding people with industryleading technological companies. Driven and passionate people play a crucial role in developing the biotechnology sector in the region, and we are only too happy to play our part in recognising them”.

Patrick Lonergan, Business Manager of Science and Engineering, NRG

www.nrgplc.com

W W W . C E L S G R O U P. C O M 2 7

Innovation Award

Innovation Award

The Innovation award recognises the development of an innovative design, process or service that has produced a major improvement in business performance, end user or patient benefit.

FINALISTS ANTnano plc ANTnano has developed the world’s first Near Real Time Technology for monitoring airborne enzymes in the manufacturing industry. The technology allows manufacturers to identify exposures to enzymes to help them protect their workforce from harmful dust and occupational asthma.

Avecia Biologics Ltd Billingham-based Avecia has developed a novel manufacturing platform for mesenchymal dermal stem cells. The platform is scalable and regulatory compliant and has reduced the cost of bulk cell manufacture by an order of magnitude compared to existing cell therapy products.

Avecia expects to gain a leadership position and first mover advantage in the emerging field of regenerative medicine.

FScan FScan has developed a series of responsive optical probes that can be used to measure the concentration of certain key bioactive species in a variety of biological fluids.

The company’s application development for the diagnosis of prostate cancer has shown great promise, with initial trial work demonstrating a reliable, accurate and specific test.

2 8 C E L S H E A LT H C O N N E C T

itro Safe Systems The Vitro Safe technology developed by this Newcastle-based company consists of interlinked incubators and workstations designed to provide comprehensive control during laboratory processing of embryos and stem cells. The unique system enables all steps in the IVF procedure to be conducted in a totally enclosed environment to reduce cellular stress and increase the viability of embryos.

WINNER Vitro Safe Systems HIGHLY COMMENDED FScan SPONSOR Newcastle Science City Newcastle Science City works to position Newcastle and the wider region as a premier location for science by creating science networks which encourage innovation and entrepreneurship, supporting the development of science based businesses. This is achieved through a number of work areas; Supporting Science Networks, the Newcastle Innovation Machine, Science Business Creation, Science Infrastructure and Education and Community Engagement. www.newcastlesciencecity.com

“It is a great honour to have won this award.

There are a lot of people doing very innovative things but to get to the commercial stage is a huge challenge, especially in today’s tough climate.

I would also like to thank RTC for their continued support of Vitro Safe Systems.”

Dr Mary Herbert, Scientific Director, Vitro Safe Systems

Outstanding Growth Award

Outstanding Growth Award

The Outstanding Growth Award recognises consistent, sustainable and profitable growth in the sector.

Organisations had to demonstrate substantial improvement in business performance and commercial success to levels that are outstanding for the size of the applicant’s operations.

FINALISTS Cambridge Research Biochemicals Billingham-based Cambridge Research Biochemicals increased its turnover by 42% last year by building its sales force and achieving buy in from all members of staff to focus on growth. The company has also increased its export sales and is acting as UK distributor and promoter of five companies based in South Korea, Switzerland, Italy and Cambridge.

IntraHealth IntraHealth is a provider of clinical services to the NHS and one of the largest independent providers of primary medical services. IntraHealth’s turnover has grown considerably over the past two years and the company has gone from employing 101 staff to over 300.

The Specials Laboratory (TSL) TSL manufactures and supplies unlicensed medicines (Specials) to pharmacists across the UK and Ireland.

The company has enjoyed consistent growth following a major improvement to workflow to achieve 24 hour delivery on 90% of orders. TSL has grown its customer base in new regions and has achieved a 99% customer retention record.

WINNER IntraHealth HIGHLY COMMENDED Cambridge Research Biochemicals

“Working in primary care is complex and challenging so we’re absolutely delighted to have won the award for Outstanding Growth and to be recognised for our team’s hard work and dedication.”

Greg Moorhouse, Managing Director, IntraHealth

SPONSOR Sintons LLP Sintons LLP is a leading commercial law firm in the North East of England which has a dedicated healthcare group to advise both private and public sector organisations in the healthcare and life science sectors. From advising on equitable access health centres to private equity transactions, their experienced team offers a full range of legal services. www.sintons.co.uk

W W W . C E L S G R O U P. C O M 2 9

Partnership with the NHS Award

Innovation Award

The Partnership with the NHS Award recognises consistent, sustainable and profitable growth in the sector.

Organisations had to demonstrate substantial improvement in business performance and commercial success to levels that are outstanding for the size of the applicant’s operations.

FINALISTS IntraHealth IntraHealth is a provider of clinical services to the NHS and one of the largest independent providers of primary medical services. The company is a key partner in NHS County Durham’s primary care pathfinder programme which was established to develop understanding of lean thinking improvement methodology in general practice.

NewGene Ltd NewGene is a joint venture between Newcastle Hospitals and Newcastle University that has been set up to provide genetic testing services using the very latest gene sequencing technologies.

The partnership aims to benefit patients by providing more accurate test results, over a shorter reporting time and at a lower cost.

3 0 C E L S H E A LT H C O N N E C T

Vitro Safe Systems The Vitro Safe technology has developed from many years of collaborative research between NHS scientists at Newcastle Fertility Centre and private safety cabinet manufacturers. This collaboration has been essential to develop the entire system with the aim of improving clinical governance, embryo viability and IVF pregnancy rates.

WINNER NewGene Ltd SPONSOR Newcastle upon Tyne Hospitals NHS Foundation The Newcastle upon Tyne Hospitals NHS Foundation Trust celebrates collaboration with organisations that have made a major difference to the NHS, reflecting their commitment to delivering healthcare at is very best. www.newcastle-hospitals.org.uk

“NewGene is grateful to Cels for this prestigious award in recognition of its work with the NHS to make the benefits of genetic testing for breast cancer and other diseases more accessible to the public.”

David Huntley, Chief Executive, NewGene

Start-Up Award

Outstanding Growth Award

The Start-Up Award regcognises newly established companies in the healthcare sector that show a promising future.

FINALISTS BioSignatures BioSignatures was a spin out of Nonlinear Dynamics to exploit key insights and technology developed by the company to create diagnostic products in unprecedented numbers. The company has already identified three possible diagnostic signatures through its trials and has signed its first commercial deal worth (over time) £500,000 – ahead of schedule.

Demuris Ltd Demuris is a biotechnology company specialising in the discovery of novel antibiotic drugs for the treatment of patients with bacterial infections. The Demuris laboratories opened in June 2009 and a pilot screen has already been undertaken for the first assay. The company has an ambitious five year plan to develop its first drug for clinical testing.

Geneius Laboratories Ltd Geneius is a new venture established to provide laboratory testing of foodstuffs and other materials destined for human use or consumption. In its first year of trading the company generated almost £100,000 in sales revenue and is on track to meet its second year objectives attracting a new customer base including several major brands.

WINNER Geneius Laboratories Ltd SPONSOR Marks & Clerk LLP Marks & Clerk LLP is one of the UK’s leading firms of Patent and Trade Mark Attorneys. With 11 offices in the UK and an associated law firm, they are able to provide a full range of integrated intellectual property services covering patents, trade marks, designs, copyright and domain names.

“We’re delighted to have been recognised by a regional industry body for the pioneering service portfolio delivered by Geneius, and welcome the opportunity to represent the North East’s entrepreneurial spirit at the National awards.”

Professor Jerry Barnes, Managing Director, Geneius Laboratories Ltd

www.marks-clerk.com

W W W . C E L S G R O U P. C O M 3 1

Technology Award

Innovation Award

The Technology Award recognises the development of a new or existing technology resulting in substantial improvements in the Healthcare and Life Sciences sector, either financial, environmental or service.

FINALISTS nano-porous solutions ltd Nano-porous solutions specialises in the development and manufacture of advanced, innovative multi-layer hollow fibres used in separation and filtration processes. The technology makes a significant reduction in carbon emissions as it provides a very efficient filtration process leading to reduced costs and increased sensitivity.

WINNER nano-porous solutions ltd SPONSOR KITE Innovation Europe KITE Innovation was established in 2006 to help bridge the gap between the academic and business sectors in supporting collaboration, enterprise, and knowledge-based business development.

KITE provides hands-on practical support to all types of initiatives in this business space. Always aiming to deliver high-value services that make a real difference, KITE can provide innovative and flexible packages which buy in to the successful outcomes of the project. www.kiteinnovation.com

Nonlinear Dynamics Nonlinear Dynamics develops proteomics analysis software that is designed to help generate reliable conclusions that are reproducible across labs. The new technology reduces the time spent analysing data, visualises and objectively quantifies the features of interest and creates a viable alternative to current approaches.

Reinnervate Ltd Reinnverate has created a novel porous polystyrene scaffold that can be adapted to existing cell culture products and applications. The technology is unique and is of significant value to researchers in biomedicine and drug development, enabling more accurate lab testing and reducing R&D costs.

3 2 C E L S H E A LT H C O N N E C T

“We are delighted to receive this prestigious award and would like to take the opportunity to thank Cels and Bruce Watson and Cay Green of Northumbria University’s Centre for Design for their assistance with the development work”.

Colin Billiet, Chief Executive, nano-porous solutions limited

BUSINESS FOR LIFE AWARDS 2010

CEREMONY & DINNER

The Newcastle Marriott Hotel Thursday 11 November 2010 Celebrating the Achievements of North East England’s Healthcare Industry Cels HealthConnect is delighted to confirm that the Business for Life Awards will be held Thursday 11 November 2010 at the Newcastle Marriott Hotel to celebrate the achievements of the healthcare industry in the region.

North East England has a successful and thriving health, healthcare and life science sector which contributes £8 billion to the region’s economy and is responsible for employing 172,000 people within the region.

These awards not only recognise and reward the North East’s top companies in the industry, but also act as a benchmark for the region’s rapidly developing healthcare sector.

The Business for Life Awards 2010 consist of the following categories: n Innovation n Export Achievement n Business Start-up n Outstanding Growth n Partnership with the NHS n Technology n Environment

…and the HealthConnect Award

BOOK YOUR TICKETS NOW Celebrate with other key members of the healthcare community of North East and applaud the industry’s achievements.

Individual tickets from £75 +VAT each and tables from £700 +VAT each.

To book tickets or to discuss sponsorship opportunities, contact Claire Mitchell on 0191 215 5518 or claire.mitchell@celsgroup.com

www.celsgroup.com

“Fast-tracking cures from

North East England to the world.”

Fiona Cruickshank, Owner, SCM Pharma

A revolutionary new way of injecting medication without a needle is in development at SCM Pharma in North East England. Working together with Glide Pharma, it could soon offer a cost-effective and easy-to-use delivery system for worldwide vaccination programmes as well as addressing the fear of needles that affects more than 10% of the world’s population. Innovation from North East England: delivering healthcare solutions for the future.

Find out more about the region’s innovative healthcare sector at www.northeastengland.co.uk/healthcare

Campaign led by

EPICC Advert:Layout 1

23/11/09

08:40

Page 1

EPICC

Services include:

Enhancing Practice and Innovation Centre for Care

> Consultancy and needs analysis > Excellence in practice accreditation > Bespoke training > Research and evaluation

School of Health & Social Care Working in partnership is the distinctive signature of EPICC. Building on our long established partnerships with the health and social care sectors, EPICC has a practical patient- service user- practitioner focus aimed at creating innovations and enhancements, making real changes and improvements in the experience of care.

A sector specific portal to expertise across the University

Contact EPICC

School of Health & Social Care Teesside University

T: 01642 738063 E: epicc@tees.ac.uk www.tees.ac.uk/epicc

Inspiring success

Join the debate that affects you and your business at MedilinkUK.com We know that the best people to identify and resolve the UK’s industrial issues are those on the front line and we believe it’s time for the agenda to be driven from the bottom up.

Backed by the Office for Life Sciences (OLS), MedilinkUK.com features tailored content and topics for the pharmaceuticals, medical biotechnology, medical technology and medical diagnostics markets.

So whether you are part of an SME or a global corporation, find your voice and help shape future Government policy, influence new NHS policies and change the way the sector does business.

Change will happen more quickly and with greater benefit for all, when the Life Sciences agenda is set for the policy makers, not by the policy makers.

3 6 C E L S H E A LT H C O N N E C T

the voice of

UK Life Sciences.

Institute for Ageing and Health www.ncl.ac.uk/iah For the past 200 years, life expectancy in the developed world has been increasing at the incredible rate of 5 hours per day. This 29 hour day, 24 for now and 5 for later, represents a great triumph for science and medicine.

Few changes in the world today have greater significance, and the medical, scientific and societal challenges of population ageing are immense.

Innovative products and services are urgently needed to ensure as high a quality of life as possible, throughout the life course. This tremendous opportunity for business is as yet under recognised and your business could benefit!

The Institute for Ageing and Health, founded in 1994, has developed to become Europe’s leading research centre in its field. Based on the rapidly developing Campus for Ageing and Vitality, on the Newcastle General Hospital site, we have established a unique, multidisciplinary environment for engagement between research, training, public and volunteer sectors, the public and business.

The Institute is a major source of knowledge and innovation with potential for translation into products or services. Our research spans: n How and why we age n Clinical aspects of ageing, particularly brain ageing n Technology to support healthy ageing and those damaged by ageing n The impact of nutrition and exercise on life long vitality n Social aspects of ageing We lead the Newcastle Science City Ageing and Health theme and are committed to seeing genuine benefit, both social and economic emerge from our world class research. We work with businesses and other organisations to support the development of knowledge and innovation to underpin new products and services suited to a society with a much greater average age.

From 2010, we are supported by the European Regional Development Fund to better support projects with small and medium sized businesses based in the North East.

To learn more about how we could support your business or project, please contact: Graham Armitage, Programme Director for the Campus for Ageing and Vitality on 0191 2481306 or graham.armitage@ncl.ac.uk

www.ncl.ac.uk/biomedicine

I have to say that the processes at your centre are the most sophisticated, joined up and collaborative of all the Trusts/ Universities that I have worked with!

Lisa Ferris, Clinical Project Manager, Teva Pharmaceuticals Ltd

Newcastle Biomedicine is a world leading collaboration of research scientists, engineers, clinicians and teaching professionals, joining Newcastle University with the Newcastle Hospitals NHS Foundation Trust and other academic institutes and NHS hospitals in the North-East of England.

The medical school’s 175 year history is intrinsically linked to the social and cultural development of Newcastle as a city and the North-East region as a whole.

Medical Education now is an excellent example of a truly regional activity with Newcastle and Durham Universities and the NHS working together to provide a ‘Regional Medical School’. We are currently training 1,718 student doctors and 429 student dentists.

The 2008 UK ‘Research Assessment Exercise’ provided an external endorsement of our international standing in key areas of research. We were ranked 8th in the UK overall for all “medical” ‘Units of Assessment’ and were in the top 5 for both hospital- and laboratory-based clinical subjects.

In cancer studies, 75 per cent of our research was classed as ‘internationally excellent’ and a further 15 per cent as ‘world leading’.

Our research is organised into 7 Institutes:

Institute of Cellular Medicine (ICM) www.ncl.ac.uk/icm ICM aims to support and develop the highest quality research in basic science relevant to patients, translational research, and clinical research, for the true improvement in the clinical management of patients with chronic disease. It has an active programme of industrial engagement with, in particular, but not exclusively the pharmaceutical industry. ICM has particular expertise in performing proof of concept studies with the capacity to extend to first in man studies and beyond.

Institute for Ageing and Health (IAH) www.ncl.ac.uk/iah Europe’s leading research institute in ageing, the IAH is a major source of knowledge and innovation with potential for translation into products or services to benefit: older people; the public and the region. The IAH recognises the need to work with business and other organisations on a commercial basis to translate research into products and services.

Institute for Cell and Molecular Biosciences (ICaMB) www.ncl.ac.uk/icamb ICaMB’s aim is to understand fundamental features of the workings of cells, with a special emphasis on problems relevant to medicine. It has an excellent history of commercialisation of its basic science and several staff have founded successful spin out companies. Other work in the institute is relevant to industry, in terms of bioprocessing, bioremediation and synthetic biology.

Institute for Health and Society (IHS) www.ncl.ac.uk/ihs IHS research is focused on people and the communities in which healthcare and other services impacting on population health is delivered. In developing commercial relationships or relationships with the NHS IHS would be able to provide support, advice and project work in relation to: clinical trials; quality of life measurement; health technology assessment; health economics and understanding and advancing innovation.

Institute of Human Genetics (IHG) www.ncl.ac.uk/ihg IHG, created in 2001 as part of the Millennium landmark Centre for Life, brings together human and medical geneticists in a custom built centre. With its unique combination of medical and human geneticists, stem cell biologists and a major NHS regional genetics service team, the IHG is now regarded as a world class centre. It provides an operational base for the North East England Stem Cell Institute (NESCI) a collaboration between Durham and Newcastle Universities, the Newcastle Hospitals NHS Foundation Trust and other partners.

Institute of Neuroscience (ION) www.ncl.ac.uk/ion The ION conducts research on a broad range of basic and clinical sciences areas relating to the function of the brain and its impact on behaviour and wellbeing. Its research is underpinned by state of art infrastructure and by access to basic science models and clinical populations. In a number of these areas it is working closely with commercial partners, and many research activities involve innovation and have the potential for commercialisation.

Northern Institute for Cancer Research (NICR) www.ncl.ac.uk/nicr NICR’s focus is research excellence in cancer studies.

It integrates programmes in drug discovery, clinical & translational research and paediatric and haematological oncology. It’s teams of molecular and cellular biologists, chemists and clinical researchers work in collaboration with stem cell biologists, cell signalling specialists and nanotechnologists across the University to identify the vulnerabilities of cancer cells and to probe the effects of novel drugs.

Our schools focus on research-led undergraduate teaching, professional development and qualifications:

School of Dental Sciences www.ncl.ac.uk/dental

School of Medical Sciences Education www/ncl.ac.uk/medev

School of Biomedical Sciences www.ncl.ac.uk/biomed

School of Psychology www.ncl.ac.uk/psychology

Over the past few years, we have invested heavily in a range of facilities to support and enhance our own research and that of our commercial partners and customers.

Specialist support ranges from large facilities such as Electron and confocal microscopy and flow cytometry to access to techniques such as bioinformatics and proteomic analysis.

Our Clinical Research Platforms combine state-of-the-art facilities with staff experienced in all phases of clinical research. They provide support throughout the whole clinical trial

process, from trial design through to assessment using MR and PET scanners to patient assessment at one of our three Newcastle-based hospital facilities or our facility at South Tees.

New facilities added in 2009 included the Sir Bobby Robson Cancer Trials Research Centre at the Freeman Hospital and a new Dental Clinical Research Facility. Plans are well advanced for a new ‘Biobank’ facility to be established during 2010, providing access to clinical samples for research.

We are fast developing a reputation as a key place to do clinical research: ‘Newcastle Biomedicine and the Joint Research Office have an extremely refreshing approach to setting up and conducting commercial clinical research.

In my mind the key success factors are: i) An awareness of industry needs and a keenness to deliver on these in a timely and consistent manner. ii) A willingness to work closely with industry, cut through red tape and remain flexible at all times in order get new research projects up and running. iii) Provision of appropriate resource and therefore an efficient service to industry.’

David Newall, Pfizer Clinical Business Partnerships Team

Further details at:

www.ncl.ac.uk/biomedicine

Trusted Technology. Caring for People

Trusted Technology. Caring for People

Warden Call Systems

Access Telecare/Telehealth Control Systems

At Home Alarm Units

Warden CallAt Home Alarms Telecare Assistive Technology

Telehealth

Concierge Software Solutions

Access Control

Local Care Alarms

The No. 1 Choice for Quality, Value & Service

Tynetec Limited Cowley Road Blyth Riverside Business Park Blyth, Northumberland NE24 5TF Tel: 01670 352 371 Fax: 01670 362 807 Email: sales@tynetec.co.uk

www.tynetec.co.uk

Tynetec – helping people to live independently for longer in their own home Tynetec, which was established in 1979, is a UK based company with expertise in the design and manufacture of Warden Call Systems, At Home Alarms, Telecare & Telehealth Equipment and Access Control Systems.

Throughout the years, Tynetec has mirrored the advances which have taken place in the telecare & access control industries.

Tynetec has a track record for continuous innovation and has been a firm supporter of national and international standards within the telecare industry. Tynetec’s range of hardware and software are all designed in house by a dedicated research and development team and all manufacturing is carried out at Blyth in Northumberland.

The company supplies equipment to hundreds of local authorities and housing associations and now as it celebrates its’ 30th Anniversary, the organisation is expanding its operation in Blyth to ensure that it continues to meet the needs of its customers with investments being made in both the production and development areas.

Tynetec’s Advent xt is now firmly established as the market leader in hard-wired warden call systems. With fully integrated Telecare, data can be accessed remotely using a standard internet connection.

4 0 C E L S H E A LT H C O N N E C T

Additional Advent xt options include combined door entry for cost effective installation. Tynetec’s SayPhone v2 and SayPhone 21 at-home alarm units also offer full telecare compatibility for either responsive or preventative telecare applications. The SayPhone 21 not only supports the full suite of telecare but can also be used for Telehealth applications. Altec Telecare & Telehealth devices are available for use with both the Advent xt hard wired warden call systems and SayPhone at-home alarm units.

Tynetec’s Altera Care Software is a low cost PC software package that allows personnel from any Care Agency to directly access Telecare & Telehealth data from the Social Alarm System. Altera Care is compatible with Advent xt hard wired systems and SayPhone 21 at-home alarm units.

Tynetec’s Altec Response is a fully featured alarm unit and is essential for all local care environments. It’s compatible with all Altec Telecare devices and operates with a typical sensing range of 100m. Tynetec’s well established range of Entel access control products offer high quality, essential features and trusted technology. Available in either functional or digital configurations the modular design allows for systems to be expanded in line with a customer’s development program. All Entel products are supplied with full DDA compliance.

Hargreaves Elsworth Patent Attorneys leaders in protecting intellectual property assets

Hargreaves Elsworth is Newcastle’s independent firm of Patent Attorneys, advising clients in relation to patents, trade marks, designs, copyright and intellectual property licensing.

Hargreaves Elsworth is very active in the field of healthcare and regularly file applications on behalf of the National Health Service, universities, spin out companies and US clients.

Since Dominic Elsworth founded Hargreaves Elsworth in 2001, the practice has built up an impressive client portfolio in the North East, other parts of the UK, Europe and the United States, handling a variety of patent, trade mark, design, technology transfer and consultancy work.

Some examples of work we have recently undertaken include patent prosecution in the areas of DNA nanowires, antimicrobial coatings, protein secretion, biomarkers, crop genetics, orthopaedic implants, surgical equipment and medical devices.

The past couple of years have seen significant improvements to the patent system for patent owners. The advent of the London Agreement has reduced drastically the cost of obtaining European patents, the UK Intellectual Property Office’s Opinion service offers a credible basis for alternative dispute resolution in patent infringement and validity cases, and the Finance Act 2011 promises to bring major tax breaks to businesses involved in R&D by proposing a 10% rate of Corporation tax on income from patents.

With the reduced cost of obtaining patents and the possibility of paying tax at only 10%, businesses need to take great care when developing new products to ensure that they have at least given consideration as to whether or not the development should be protected by patents.

Members of the practice have backgrounds in chemistry, biotechnology, engineering and electronics.

Our professional expertise is backed up by properly trained support staff and the latest office management technology, allowing us to provide a very high standard of advice and service, whilst keeping our costs down to moderate levels.

Hargreaves Elsworth’s overriding goal is to ensure that the advice given to its clients is not only legally correct, but is tailored to their business requirements, and delivered at reasonable cost.

For more information, contact Dominic Elsworth of Hargreaves Elsworth, 6 Charlotte Square, Newcastle, NE1 4XF

W W W . C E L S G R O U P. C O M 4 1

I N N O V AT I O N F O R T H E F U T U R E T O D AY

Newcastle and the North East have always been places that thrive on scientific and technological innovation.

well as through business development models which are as innovative as the products they will market, said Estelle.

Realising the full economic potential of research and innovation is the task of Newcastle Science City, a partnership between Newcastle University, Newcastle City Council and One North East. It is a pivot between academia-led research and commercialisation, focussing on three themes: ageing and health, stem cell and regenerative medicine and sustainability.

Newcastle Science City’s close collaboration with the Institute of Ageing and Health at Newcastle University, is a prime example of a partnership seeking out valuable business insights, said Estelle.

The city’s strong research capabilities in these fields have set the direction for the future, says Newcastle Science City’s programme director, Estelle Chatard. “We’ve got the scientific expertise on our doorstep and now we need to maximise the economic potential it offers, she said.

“What really differentiates us though is the way we’re approaching that opportunity – instead of looking for a problem to solve with new technology, we’re looking for the insights and societal issues that can be solved by research underway in the city. Essentially we’re establishing a market and then investigating the solution.”

One of the key success indicators for the city is the creation of sustainable, high-growth science and technology companies, and Newcastle, as a science city, is expected to create 500 new companies in the next 15 years.

How will these ambitious aims be met? Through a mixture of traditional methods like skills development and innovation matchmaking, as

4 2 C E L S H E A LT H C O N N E C T

“The biomedical sector has really been opened up in the past decade and this has been especially true in the North East. What we’re doing now is working with the leaders in the field to understand the problem and the technology and see how we can develop an economically advantageous solution.

“That’s the essence of Newcastle Science City – linking research to the people with the vision and drive to take technology to market.”

Driving innovation forward Where Newcastle Science City really breathes life into insight-led commercialisation is through the Newcastle Innovation Machine, the flagship project that seeks out market opportunities, said the organisation’s chief executive, Peter Arnold.

“This approach means a strong business case is developed, and, crucially, the system keeps the expertise, intellectual property and product development in the region – which is so crucial for our economic prosperity,” he said.

The Newcastle Innovation Machine is driven

by Innovation Managers, entrepreneurial spirits

recruited from successful businesses around the world for their vision, drive and know-how.

Their role is to investigate insights, understand the challenge, the size of the market and whether research in Newcastle can meet the need. As the Innovation Managers develop a business case they are spun out of Newcastle Science City as an incorporated company.

Peter said: “The challenges faced by successful entrepreneurs inside and outside NIM are the same. To overcome them requires the same qualities of vision, tenacity and drive. What the machine provides is the steady environment and tools they need to really get to grips with the market and the solution so that when they spin out they have the best chance of success.”

Partnering with the wider business community Newcastle Science City is also becoming an integral part of the region’s vibrant life sciences sector.

“Life sciences contribute millions of pounds to the regional economy, so if we can help those businesses grow, that’s all for the good. We do this by making many of the services the Innovation Managers use available to external businesses, too,” said Estelle.

As an example, Estelle points to Newcastle Science City’s First Friday meetings, a monthly networking format developed by entrepreneurs to meet other business owners from the science community.

According to Dave Stevens of Pitman Training, the diversity of the firms represented makes First Friday an ideal opportunity to strengthen and discuss business opportunities.

Insight led innovation case study

He said: “The format works really well. It attracts a great mix of people from across the region from a number of sectors and business perspectives. I’ve used the events to progress fund raising for one of my other companies and even sold a training course.”

Limbs Alive is a venture that started with a number of insights into the current problems and opportunities arising from therapy for children and adults who have lost upper limb function through a stroke or cerebral palsy – a condition called hemiplegia.

And during 2010, Newcastle Science City will host a number of courses to help external businesses pick up the skills required to turn innovation into commercial reality quickly and effectively.

Through specially designed video games, Limbs Alive provides effective and convenient therapy for children and adults who have lost upper limb function.

Estelle concluded: “We want to do nothing less than make Newcastle Science City an integral part of the economic vibrancy of the city. To get there, we’re fostering sustainable start-ups that keep scientific expertise in the region and by helping external businesses access the skills and resources they need to succeed.”

Prof Janet Eyre, Professor of Paediatric Neuroscience at Newcastle University and her team identified a lack of cost-effective therapies, in spite of research which shows patients’ quality of life and employment opportunities are drastically reduced if they cannot perform activities requiring two hands.

For more information, visit www.newcastlesciencecity.com.

“Essentially, a crucial area of stroke and cerebral palsy rehabilitation is compromised by a lack of cost effective therapies,” said Prof Eyre. “The benefit of daily rehabilitative therapy, sustained over a long period and focused on those movements skills is well-established but the costs are too high if this is delivered by a therapist.

could follow in their own home without requiring supervision from an occupational therapist, there would be a significant demand for the product.

The team has written bespoke video games for use on either PCs or the Nintendo Wii gaming system. It works by using highly motivating games to encourage patients to practice specific hands and arm movements. This also strengthens the neural pathways which improve dexterity and co-ordination in every day life.

“Business development is not our core expertise,” said Prof Eyre, “so having Newcastle Science City in partnership with NHS Innovations North on hand has helped us take the idea from an unmet need to a stage where it is very close to becoming a commercial reality.

During 2010 the games will be trialled at the Royal Victoria Infirmary in Newcastle and if successful will become commercially available.

“We knew that if we could develop an effective system that patients

W W W . C E L S G R O U P. C O M 4 3

DESIGN FOR LIFE...

WITH INTELLECTUAL PROPERTY

McDaniel & Co. is a niche practice based in Jesmond, Newcastle upon Tyne. It was established by Husband and Wife team Niall and Rozanna Head-Rapson.

The Firm is the only dedicated specialist Intellectual Property Practice in the North East of England. The firm also houses a specialist Family Law department, headed by Rozanna, and a dedicated Sports Law unit led by recently appointed Partner Rod Findlay.

McDaniel & Co. was established is 2005.

Like a lot of life science companies it was a start up business having only 3 members of staff but has grown in the intervening period to 17 with ambitious plans to expand further.

The firm acts for businesses all over the country and overseas - not just the North East. The firm is actively attracting business to the area as a result of its expertise.

A core aspect of the Intellectual Property Law practice is assisting organisations in both the public and private sector that have a significant interest in the identification, protection, exploitation and commercialisation of Intellectual Property.

In fact the entirety of the clients of McDaniel & Co.’s Commercial Intellectual Property Law practice has either a significant interest in Intellectual Property or more pertinently Intellectual Property is a core asset and revenue generator of their business.

Niall has a background in life science having undertaken his first degree in Biotechnology at Kings College in London. Niall has worked with a number of Life Science Companies

4 4 C E L S H E A LT H C O N N E C T

over the years and regularly advises businesses in the sector in respect of their Intellectual Property capture and protection.

This can range from helping to identify new inventions, mapping the Intellectual Property landscape, assisting with protection of Intellectual Property portfolios to enforcing those rights.

Not all of the work revolves around litigation though. The firm has experience in the Venture Capital Sector acting for both funds and investee companies in raising finance.

The firm has also been involved in multi national licensing deals and sales of license income to raise finance.

McDaniel & Co. has the broad range of skills within its practice to assist in the creation, expansion or the protection of the business.

In January 2010, McDaniel & Co. appointed its third partner, Rod Findlay. Rod has 15 years post qualification experience as a litigator and lawyer with regulatory experience and was recognised in Chambers

& Partners and Legal 500 for his litigation experience. Rod’s experience covers a wide range of issues but predominately Regulatory Law, Licensing and Franchising.

Rod was responsible for the design and implementation of a large franchising system.

This involved designing an application process to select 14 out of 19 applicants against their business plans, leading the assessment team and drafting the legal documents required to bring this revolution into being.

In 2008, Rod was appointed as Chief Executive Officer of Gateshead Thunder, the North East’s only professional rugby league club, and remains with the club in a NonExecutive role. www.mcdanielandco.co.uk

Paragon Rapid Technologies – Bringing ideas to life!

With “Model of Excellence” as the company’s working motto, Paragon Rapid Technologies is aiming for the high ground in prototyping services, with a major focus on rapid product development and technical vacuum casting within the medical and healthcare sector.

Paragon have built a reputation of high quality service and products with their ever increasing customer base of Design Houses, OEMs and Healthcare Specialists. Their success is the result of Innovation and commitment, always striving to exceed the limits of the process and the expectations of their customers. Paragon put a great deal of focus and effort into Research and Development, in order to keep ahead of the ever changing requirements of today’s market.

By combining the latest stereolithography and casting processes with traditional modelmaking and innovation, Paragon are able to offer a broad range of solutions within the medical sector. This includes the manufacture of prototype electronic equipment and devices. Development models, training aids for surgeons, nurses and students, Exhibition or Display models to illustrate procedures or represent anatomical features. Accurate resin models of bone structures for maxillofascial reconstruction, prosthetics and Prototype parts for implants.

Paragon’s services can accommodate the manufacture of one off models, short runs for testing, evaluation and low volume production. The range of PU, epoxy and silicone materials

available includes approved medical and food grades as well as materials to simulate almost all production plastics and rubbers.

By working with partner companies, Paragon can not only offer full design and development support with ISO 13485 accreditation, but also additional services such as 3D scanning, data capture and rendering as well as full manufacturing processes.

Paragon are relied upon by Blue chip companies, OEMs, Universities and Design Consultancies throughout the country to deliver the best quality of models, components and service on time as well as supporting their customers with innovation and problem solving, adding value to the end product.

For more information regarding Paragon’s services please contact a member of the team on 0044 (0) 1325 333141, info@paragon-rt.com, www.paragon-rt.com or visit us at MEDTEC exhibition at the Birmingham NEC on April 27th & 28th, stand 2025.

W W W . C E L S G R O U P. C O M 4 5

Staithes 2 | The Watermark | Gateshead | Tyne & Wear | NE11 9SN + 44 (0)191 460 9295 + 44 (0)191 460 6138 www.wh-partnership.com

Over two decades WHP has delivered projects in the following sectors:

The services we provide are: Design

Biotechnology

Project management

Pharmaceutical

Procurement services

Food & Drink

Process & Critical Utilities Installation

Cosmetics

Cleanroom & Lab Construction

Renewable Fuels

M & E services

Health care

Automation & Control engineering Commissioning & Validation Maintenance

WH Partnership 2009 was a highly successful year for Gateshead-based WH Partnership (WHP), with an ambitious expansion plan that saw the firm double its key staff, appoint three new directors, achieve a turnover topping £5m and move to prestigious new premises in The Watermark.

WHP is a specialist design and build company, integrating cleanrooms, laboratory and process technology. It offers a full range of design, installation and project management services, from consulting through to operations with flexible entry and exit of services at any point in the process.

Over two decades, WHP staff have established an enviable reputation and proven success in the biotech, cosmetics and pharmaceutical industries, particularly for process and critical utilities projects. Its third decade promises to be the most exciting yet, as the company has expanded its services to offer a total turnkey package, recruiting new directors Richard Anderson, David Dunn and Mike Hunter, who have designed and managed many of the UK’s specialised pharmaceutical cleanrooms and laboratories.

This additional expertise and experience has enabled the company to compete for, and win, more local, national and international projects, including three major contracts in the UK and a multimillion pound contract for cosmetics giant Avon in Poland.

In the UK, this has led to Government-sponsored contracts in research and development, as well as strong commercial successes. These include building a new virology containment facility for the Veterinary Laboratories Agency and a contained effluent treatment system for the FRS Marine Laboratory, Aberdeen.

The new contracts will see up to 20 jobs created in the region and other key personnel recruited this year include top biotechnologist

4 6 C E L S H E A LT H C O N N E C T

Dr. Rob Johnson, along with experienced project managers and in-house CAD designers. WHP’s rapid expansion has seen it make a move to its own office building on The Watermark, to accommodate its increasing workforce and provide better facilities for clients.

Bespoke workshops have also been acquired nearby to build, test and develop modules, control systems and specialist piping systems.

Nigel Hall, director, said: “The Avon contract shows that worldclass companies can find the right expertise in this region. WHP has worked in the cosmetics, pharmaceutical and biotechnical industries for two decades, and this project builds on that success, while bringing in additional expertise from our new senior management team.”

BRINGING MICROFLUIDICS TO LIFE

Epigem manufacture microfluidic consumable components and process control boards for commercial instrumentation used for bioanalysis.

Extensive solution provision experience supports companies and Universities, in the healthcare sector, develop innovative new products and applications. Applications supported include drug discovery and diagnostics. For example, assays at the DNA, protein and cultured cell levels- for various screening environments including in-vitro models of the microfluidic environment within blood capillaries; blood separation modules are providing both minimised sample collection and faster, higher precision analysis. Microfluidic fabrication processes are employed for both new materials and chemicals synthesis and formulation and device fabrication as well as analysis and sample preparation procedures.

Epigem operate within the global community of technology developers concerned with product miniaturisation (motivation: smaller analyte and reagent quantities, point of care products) and process intensification (motivation: smaller, faster, more efficient, lower cost, environmentally better). Polymer microfabrication - well established for the manufacture of microtitre wells and disposables such as pipette tips- in the hands of Epigem has now become both multifunctional – enabling the integration of optics, electronics, fluidics, magnetics, biology, etc. and multidomain – enabling silicon sensors and control and data processing to be packaged within multilayer boards. This is enabling the miniaturisation of chemical and biological analysis and convergence with electronics and communications technology.

Other applications include environment protection, forensics and food safety.

The processes operated by Epigem enable chemicals, polymers and biochemicals to be synthesised, formulated, manipulated and delivered, in the form of thin coatings on rigid or flexible substrates and in the form of fine droplets processed within hair-like channels (100 microns dimensions) or delivered as sprays. Droplet processing within the laminar flow environment of microfluidics enables complex emulsions and encapsulation to be undertaken relevant to therapeutic and diagnostic healthcare.

In 2006 Epigem were contracted by central Government, the EU and the Regional Development Agency, OneNE, to provide micro and nanotechnology integration services. To date, the Fluence Microfluidics Centre ( www. fluence.co.uk ) has supported 46 companies and 24 Universities with 30% International clients. Much of the research of our clients is leading edge and has been published at Conferences and Journals. Multinational companies and start up companies have been supported from the proof of concept stage through to commercialisation. The Fluence Centre also supplies microfluidic modules for training purposes to teach the basic microfluidic function including mixing, droplet generation and separation.

The general strategy of Fluence is to develop and supply multilayer processor boards (like printed circuit boards plus biology, optics etc as well electrical circuits). A series of combinable functions are either connected within a single layer or between layers or between separate boards, where one board could be re-usable and another disposable.

The functions provided can be fluidic. For example, liquid and gases can be pumped along channels and flow controlled using pneumatically actuated diaphragm

valves. Electrical circuity can be integrated for connection to sensors or actuators or comprise electrodes for sensing or separation or pumping.

Proprietary leak free sealing techniques enable fluid connection between modules at the micron scale. Polymer micro-optics can be integrated or optoelectronic light sources and detectors. The Centre uses a range of fabrication processes for creating these functional microstructures and for controlling surface chemistry such as channel wall wetting characteristics.

Microfluidic fabrication processes for printing and imprinting coatings and microstructures are also being used to develop high volume polymer electronics products such as flexible displays that themselves could in the future become integrated with bioelectronic multiparameter sensors.

Epigem Ltd, Malmo Court, Kirkleatham Business Park, Redcar TS10 5SQ T: 01642 496 300 F: 01642 496 301 E: info@epigem.co.uk www.epigem.co.uk www.fluence.co.uk

W W W . C E L S G R O U P. C O M 4 7

NORTH EAST INNOVATORS TAKE ON THE WORLD

The UK and the North East in particular has a world-class innovation record and our ability to foster innovation will play an important part in our recovery from the global downturn and help secure our future prosperity.

The region is already home to more than 500 leading international companies, including 40 per cent of Dow Jones listed businesses, and in 2007 the North East was ranked among the top five performing regions for foreign direct investment.

And it’s not difficult to see why this is the case. There has been a multi-million pound investment in research, while we have excellent connectivity, academic excellence within the region’s universities, a dynamic and flexible skills base and a superb support structure for inward investment.

The region’s strong industrial heritage is providing a platform for a renaissance in the economy and we are leading the way in some of the world’s fastest growing industry sectors such as energy and low carbon technology, chemicals, automotive and advanced manufacturing, digital media and animation. The UK is also a recognised global centre of excellence for life science innovation and delivery.

While there is no doubt the economic downturn has had a

significant impact on the North East economy, the total annual value of value of goods exported from the North East still stands at more than £10 billion.

And yet, despite our successes, the actual number of companies that export is small so we want to encourage more companies to take up the export challenge.

Research has shown that companies which export are more resilient. Our challenge is to ensure that businesses know that help is at hand for North East firms wanting to navigate out of the downturn by seeking out new business opportunities overseas.

UK Trade & Investment can help companies, including those in the life sciences sector, find the markets that can make the difference.

Last year more than 300 companies across the North East benefitted from our support while a national survey recently confirmed UKTI had helped 20,700 companies and it’s estimated our support helped them generate an additional £3.6 billion of profit.

David Coppock International Trade Director UK Trade & Investment in the North East

For more information call the North East International Trade Hotline on 0845 05 05 054 or email enquiries@ukti.rito.co.uk or visit the web site at www.uktradeinvest.gov.uk

Gateway to Global Growth Helping you see your true global potential Are you are a small- and medium-sized enterprise (SME) with an innovative product or service with global appeal?

Are you based in North East England with five or more employees?

Do you want to break into a new market?

Do you have at least two years of successful exporting and with ambitions to further grow your business in overseas markets?

You could be eligible for UKTI’s Gateway to Global Growth programme – a 12 month comprehensive package of strategic business support and a range of exclusive offers which will assist you in your market preparation and market penetration.

To find out more contact the Regional International Trade Hotline on 0845 05 05 054 or e-mail

enquiries@ukti.rito.co.uk

HELPING TO KEEP THE MEDICAL INDUSTRIES SAFE

Rigel Medical is a market leader in providing electrical safety test equipment for the medical industries.

Rigel manufactures medical and electromedical test equipment.

Rigel is one of the longest established brand names in the industry with its origin dating back to the 1970’s. Designed by the Liverpool Hospital University, Rigel launched the world’s first IEC 601 electrical safety analyser, known as the Rigel 8001 Liverpool Safety Tester.

Rigel Medical continues its commitment to providing innovative and portable biomedical test equipment. To meet the test requirements of the new IEC 62353, Rigel Medical launched the Rigel 288 Portable Electrical Medical Safety Analyser in 2007.

The 288 quickly became a benchmark analyser, combining robust hand-held housing with full graphics display, alpha-numeric

keyboard, large internal memory and Bluetooth technology.

In 2008, a new era started for Rigel Medical with the introduction of handheld functional testers and simulators, including an NIBP (BP-SIM) and SPO2 (SP-SIM) simulator.

New concepts are offered to customers wanting easy of use and flexibilty when testing “in the field”. For example, the Med-eKit is designed to store a range of medical test equipment in one rugged wheeled case, allowing test engineers increased flexibility when working out in the field.

Rigel’s most recent addition to the product range is a 6-in-1 vital signs simulator, combining the functions of SpO2 and NIBP simulators along with those of a patient simulator. This handheld unit ensures only one instrument is required as opposed to the traditional three and it fits neatly in to the Med-eKit trolley.

The Rigel 377 electrosurgical analyser is next to join Rigel’s product range, with colour user-interface and fast testing options, it’s designed to make the testing of diathermy machines faster, easier and safer.

Rigel Medical are dedicated to reducing test time and increasing the flexibility of those testing medical equipment in an ever increasing demand for cost savings. info@rigelmedical.com or 0191 587 8730 www.rigelmedical.com

5 0 C E L S H E A LT H C O N N E C T

YOUNG AMBASSADOR JOINS PROCESS INDUSTRIES

A ‘SCIENCE whiz’ is giving young people in the North East a voice after becoming a young ambassador and regional board member of sectors skills body, the National Skills Academy Process Industries.

Pharmacology Honours graduate Mhairi Anderson, 27, has joined the board with the aspiration of encouraging more young people to take up careers in the process industries.

The employer-led Skills Academy works as a bridge between business and training specialists, in a bid to upskill the current workforce and promote careers in the chemicals, pharmaceuticals and polymer industries.

The sector is predicted to need 30,000 new employees and 10,000 new graduates in the next decade, to offset the loss of older workers set for retirement.

The North East process industries are a key part of the regional economy, turning over £6.4bn per year and employing 22,000 people.

A senior research scientist for sanofi-aventis in Alnwick, Mhairi joins a group of senior industrialists helping employers to tackle crucial skills issues. As a young person working in industry, she hopes to bring a fresh perspective to the Academy’s activities across the North East, and is looking forward to the challenge.

“When I first found out about the board I was

5 2 C E L S H E A LT H C O N N E C T

very keen to get involved. It’s so important to show young people the opportunities that are out there, and demonstrate how they can apply the subjects they have learnt at school and in higher education,” she said.

“Role models have a big part to play in showing that careers in science or maths aren’t outdated and old fashioned, and that actually lots of young people work in the industry and have a great time doing it.

“I’ve been incredibly lucky to have benefited from a high standard of training and opportunities at sanofi-aventis, which has had so many advantages, both personally and to my employer. I thought that when I left university I was qualified and ready to start work, but I quickly realised that was only the start. I think that preconception is one of the big problems facing school and university leavers, and that’s where getting the right training and advice can really help in getting them get off to a good start in their careers and making them highly employable.

“Young people can add a whole new perspective and innovation to the industry, and have a lot to offer. I’ve recently been trained as a STEM ambassador, and in this way I hope to tackle young people’s preconceptions, and show that careers in science can be fun and worthwhile. In combination with my appointment as a board member for the Skills Academy, I see this as a logical step in helping to share my experience and bring science to a young audience.”

The Academy’s Regional Skills Manager for the North East, Kevin Thrower, said: “We are very pleased to have Mhairi on the board.

Having a younger voice on skills issues will help us to tailor our activities in terms of what we deliver for local employers.

“The average age of the industry workforce is around 55, so it can be hard for young people to relate to the career opportunities that the process industries can offer them.

Mhairi’s appointment is a step in the direction of changing that perspective, and we are confident that she will prove to be a fantastic young ambassador for the industries.”

Mhairi is one of five young ambassadors being recruited to the Academy’s boards in key industry hotspots around the UK.

Integrated

Solutions from drug discovery to patient care

Pall Life Sciences – Developing solutions for life science industries from drug discovery to patient care Pall Life Sciences provides cutting-edge products and services for discovering, developing and producing biotech drugs, vaccines and classic pharmaceuticals. In hospitals, patient therapy has become increasingly complex and our medical filtration products play a key role in the reduction of serious complications and Healthcare Associated Infections. © 2010 Pall Corporation. Pall and are trademarks of Pall Corporation. ® indicates a Pall trademark registered in the USA. Filtration.Separation.Solution.SM is a service mark of Pall Corporation. GN09.4279

Filtration. Separation. Solution.SM

www.pall.com/lifesciences

RELOCATION AND EXPORT SUCCESS SIGNALS EXCELLENT YEAR FOR HART BIOLOGICALS IT’S BEEN an exciting year for Hart Biologicals Ltd, culminating in recognition as Exporter of the Year at 2009’s CELS Business for Life Awards.

The health diagnostics company moved to its own purpose built production facility on the outskirts of Hartlepool earlier this year while successful international trade missions helped to more than double export sales.

Hart Biologicals was founded in 2002 to supply equipment and reagents for the monitoring of blood clotting in various hospital departments.

Traditionally serving the UK healthcare sector such as hospitals, GP surgeries and pharmacies, Hart Biologicals is now increasingly looking to overseas markets.

It has increased export sales by 73% over the last year, more than doubling its original target of 30%, and is now trading extensively with the USA, Europe and Asia.

It was that kind of success which prompted CELS to recognise Hart Biologicals with the Export Achievement Award at the Business for Life Awards.

Mike Asher, CEO of CELS, said: “Hart Biologicals is a worthy winner of the Export Award. International trade is undoubtedly one of the main ways of staying afloat in a recession and one which Hart has embraced.”

Hart Biologicals’ new base is a 10,000 sq ft unit at Hartlepool’s Queen’s Meadow Business Park that includes offices, production facilities and research laboratories, all in a landscaped area with secure car parking and external areas. It also invested in state of the art freeze drying and filling equipment as part of its growth.

Hart Biologicals has continued to strengthen links with a range of international biomedical firms including Pentapharm and Dynabyte in Germany and Haematex in Australia.

The Pentapharm partnership has proved particularly fruitful and led to the marketing in the UK of the ROTEM thromboelastometry system, used to investigate trauma or surgical patients who are bleeding uncontrollably during or after surgery. It also prompted the German

5 4 C E L S H E A LT H C O N N E C T

company to establish its own subsidiary in Hartlepool to work specifically with Hart Biologicals.

Pentapharm manufactures the hardware while Hart provides the reagents for the system which is being successfully used in British military medical units in Afghanistan. The technology can save crucial time, costs and the level of blood-stock used to treat a patient by enabling doctors to see which blood products the patient requires to stop the bleeding.

Managing director Alby Pattison said the advantage of the ROTEM system was that it enabled blood tests to be carried out at the point of care reducing obvious delays and costly mistakes.

He said: “The equipment sits in the corner of an operating theatre or trauma centre and gives extremely quick and reliable results which can save lives.

“The operating team can monitor the condition of the patient’s blood clotting capability, gaining vital information on the best blood products to give the patient to stop the bleeding – especially important in trauma cases and liver or heart surgery.”

The ROTEM system is proving particularly popular with hospitals in Thailand and Indonesia where there are relatively high levels of motorcycle accidents requiring trauma surgery.

Despite the successes of 2009, Hart Biologicals, which employs six full-time and one part-time staff member, takes a philosophical view of growth and is keen to achieve steady rather than rapid expansion.

Alby added: “It has been a very exciting year for Hart Biologicals not least with the move to purpose built premises. The companies we are dealing with expect us to look the part and with this building, we look the part of a diagnostics company.

“I’m confident we can continue growth in 2010 and with our new freeze drying and filling equipment, we can use our specialist knowledge within the blood coagulation field to develop our contract manufacturing capabilities.” www.hartbio.com

W W W . C E L S G R O U P. C O M 5 5

The GlaxoSmithKline (GSK) mission is to improve the quality of human life by enabling people to do more, feel better and live longer. The company develops innovative medicines and products that help millions of people around the world.

The GSK site at Barnard Castle is a key member of the Global Manufacturing and Supply division and produces some of the world’s leading sterile, inhaled, topical and oral medicines. The site makes over 40 different products, exporting more than 90% of the 200 million packs produced each year.

The products made at Barnard Castle treat a wide range of diseases, including leukaemia, HIV, MRSA, thrombosis, asthma, bronchitis, hay-fever, migraine, skin diseases, ulcers, cold sores and nausea after chemotherapy or radiotherapy. The site is a highly valuable contributor to world health.

As well as manufacturing a range of established products, the Barnard Castle site is also a key player in GSK’s new product introduction division.

The site’s aim is to introduce new products at the earliest opportunity by working in partnership with research and development from before the early stage clinical trials right through to market.

The site’s excellent sterile liquid filling reputation has recently given Barnard Castle the opportunity of being the site to fill the first GSK biopharmaceutical and a key player in the manufacture of the H1N1 vaccine. As a new product introduction site, cutting edge technologies, novel treatments and new dose forms continue to come to Barnard Castle, maintaining innovative pharmaceutical manufacturing in the heart of rural Teesdale.

GlaxoSmithKline, Harmire Road, Barnard Castle DL12 8DT Site Director: Roger Connor

Next Generation Sequencing Academic excellence. Clinical expertise Next Generation Sequencing and Genotyping Services Next generation sequencing and genotyping technologies are revolutionising biological research and molecular diagnostics by permitting rapid large genome or DNA fragment length resequencing and high throughput SNP detection at high levels of accuracy and low cost.

NewGene is a molecular diagnostics and research services company. By combining next generation technologies with our significant technical capability and expertise in both genomics research and molecular diagnostics we are able to offer rapid and cost effective DNA and RNA sequencing and genotyping.

We have an excellent track record in DNA sequencing for research projects and can offer: n Re-sequencing / amplicons, shotgun or capture n De novo sequencing, transcriptome sequencing, epigenetics and metagenomics n Chip-Seq and miRNA sequencing n SNP detection and SNP genotyping n Sequence capture services Diagnostic tests available currently or in the near future include: n Hereditary cancer testing - breast and colon n Metastatic colon cancer - K-RAS and B-RAF mutations n Haemato-oncology - BCR-ABL and JAK-2 mutations n Haemochromatosis n Atypical haemolytic uraemic syndrome n Limb girdle muscular dystrophy

We are able to offer these services through our expanding range of high throughput platforms that currently include:The Roche 454 Genome Sequencer FLX produces individual reads up to 450bp with a total capacity of 500Mb per run. This significant capacity can be utilised economically by combining bar coded samples on the same run.

The Sequenom™ is a high capacity mass array DNA genotyper. This technology is able to distinguish stretches of DNA sequence that differ by one, or a small number of bases and therefore is well suited to identifying individual SNPs. For more information contact us at: T: 0191 242 1923 M: 07772 510590 E: info@newgene.org.uk

NewGene – Winner of prestigious North East Business for Life “Partnership with NHS award” 2009

5 6 C E L S H E A LT H C O N N E C T

clear practical advice

When managing risk and making complex business decisions you need a law firm that understands your point of view. At Watson Burton we take the time to understand your business objectives and work in partnership to help you achieve long-term success.

To discuss your business needs call our legal experts

0191 244 4444 www.watsonburton.com

novus environmental bespoke waste management solutions novus environmental is a specialist waste management company providing high quality, value-for-money solutions for the collection and disposal of challenging wastes including: clinical waste

pharmaceutical waste

medicines

sharps

animal by-products

confidential waste

novus environmental is fully licensed and has the technical and logistical ability to provide a dedicated, responsive and reliable service.

Whether you are a based in the private or public sector, please contact us, we are here and happy to discuss the best method for managing your requirements.

Phone us on 0844

770 0012 or visit our website www.novus-environmental.co.uk

Vetspeed - Novus Environmental Half Page Advert for ERBI Directory.indd 1

novus environmental Part of the Vetspeed family

23/12/2009 09:04:13

W W W . C E L S G R O U P. C O M 5 7

chemiSPEC: Characterisation and Analysis Services for Industry At chemiSPEC we help our customers in a wide range of industry sectors – including pharmaceutical, fine and specialty chemicals and health care – with the characterisation of their products, by products, contaminants, etc.

We offer a wide range of services from the routine provision of NMR and MS data through to complex problem solving.

Examples of our services include: l Provision of NMR and MS spectra to your desktop l Spectral Interpretation l Complex Mixture Analysis l LC-MS and LC-NMR Analysis l Structure Elucidation l Method Development contact: Bill Campbell 01388 779051 07711771289 bill.c.campbell@gmail.com www.chemispec.co.uk

Global reach and in-depth knowledge of IP for all industries Intellectual Property: Release its potentiall

NRG Group is a multidisciplinary recruitment business with a head office in Newcastle, and branches in Tees Valley, York, Manchester and Edinburgh.

We are well positioned to offer services across the full breadth of disciplines and geography required, such as: n n n n

Scientific Technical & engineering Sales & commercial Financial

n Executive Search & Selection n IT, Human Resources n Industrial

NRG Scientific Practice are experts in the recruitment of specialist staff for the pharmaceutical, life science, food, chemical and biotechnology sectors throughout the UK. The Technical Division is dedicated to key sectors covering automotive, electronics, FMCG, pharmaceutical, food, engineering, nuclear, utilities and offshore/marine industries. Specific disciplines covered include all engineering from design and development, production and process, logistics & supply chain, quality, commercial, procurement to facilities and management posts for permanent, interim or contract.

Patrick Lonergan, Business Manager, Engineering & Science, Northern Recruitment Group

For further information please contact: Jason Lumber on +44(0) 113 233 0100 or email jlumber@hgf.com

5 8 C E L S H E A LT H C O N N E C T

Telephone: 0191 2321222 Direct Dial: 0191 2604431 Email: patricklonergan@nrgplc.com

hgf.com

www.nrgplc.com

Electrochemical Sensor Technology (EST) ltd.

EST was formed from a successful university research group. EST is based in Castle Eden in County Durham, England.

Our sensors have been used in a variety of environments ranging from water quality testing through to medical applications. We have wide experience, and have designed sensors for gases in air, gases dissolved in liquids, and a range of metal ions, and organic species.

Our services and expertise includes the following activities: n Research and development of chemical sensor technologies. n Design and manufacture of sensors and sensor components, electrodes, connectors, etc. n We can carry out practical investigations using a variety of methods such as Cyclic Voltammetry (CV), Linear Sweep Voltammetry (LSV), and Differential Pulse Voltammetry (DPV), etc. n We can assist in the design, and small quantity manufacture of sensors, particularly of disposable units.

Our expertise in producing practical and easy to use sensor systems is demonstrated by our recently introduced portable sensor, for the measurement of ammonium ion (NH4+) dissolved in liquids.

The hand-held meter, which is known by the acronym ‘ESTAPAS’ offers significant technical and commercial advantages when compared with the usual colour change chemistry methods used for the analysis of this important measurand. The meter is supplied complete in a small carry-case making it suitable for in-the-field use, or in the laboratory

Contact: Neil Marshall, EST Ltd., The Old Brewery, Castle Eden, County Durham TS27 4SU Tel. 01429 835 455 www.electrosensortech.co.uk

Strategic marketing services that help you win new business, develop new relationships and build a strong brand.

Horizonworks Marketing Ltd can act as your outsourced marketing department where we can manage the whole marketing function for you or we can work with you on a project by project basis.

We specialise in: Strategy & planning Project management & campaigns Communications & branding Health checks & mentoring Our approach is simple – we help businesses get to where they want to be through focussed marketing.

T: 0191 519 7416 E: info@horizonworks-marketing.co.uk www.horizonworks-marketing.co.uk

W W W . C E L S G R O U P. C O M 5 9

F

Research & Innovation

ew universities have comparable research strengths

across the Sciences, Social Sciences, and Arts and Humanities; yet Durham is compact and interactive enough to develop new approaches, questions and research ideas that transcend interdisciplinary boundaries. The pioneering work of our academics has enhanced human life and well-being, deepened our knowledge of the universe and everything in it, and created new industries that diversify and strengthen our national and regional economies.

Fig 1: Cell patterning in the growing root tip of Arabidopsis, highlighted by red stain

Our School of Biological and Biomedical Sciences (SBBS) and Centre for Bioactive Chemistry (CBC) undertake extensive research in the life sciences in the following areas: Regenerative Biomedical Technologies underpin Durham’s contribution to the North East Stem Cell Institute (NESCI) and associated company spin outs. SBBS and CBC, have state-of the art facilities available in cell culture, cell templating to novel synthetic supports, cell imaging and molecular analysis. SBBS also houses a major research grouping examining the molecular basis of degenerative diseases related to laminopathies. We also offer a self-contained translational research facility which is available to industrial partners.

Crop Production and Protection - SBBS houses one of the UK’s major clusters of plant scientists with specific research skills in plant productivity, stress tolerance and crop protection. Applied research activities include the spin-out company Creative Gene Technology Ltd (www.creativegenetech.com) which is concerned with the engineering of plants for resistance to invertebrate pests (insects, slugs, nematodes), the discovery of novel chemical agents in a joint programme with chemists in the CBC and the production of commodity chemicals from oil seed crops.

Biophysical Sciences - our newly formed Biophysical Sciences Institute offers ‘one-stop’ interdisciplinary solutions to basic and applied research problems, drawing on the expertise and research facilities of biologists, chemists, physicists, mathematicians and

6 0 C E L S H E A LT H C O N N E C T

Fig 2: Cells expressing the POLARIS gene (stained blue), required for correct root growth in Arabidopsis

engineers. Facilities include: a range of confocal, fluorescence and electron microscopes, mass spectrometry facilities for small molecule and proteomic applications, high throughput DNA sequencing and a cell technology suite. www.durham.ac.uk/biological.sciences www.durham.ac.uk/bioactive.chemistry www.durham.ac.uk/biophysical.sciences www.nesci.ac.uk The Wolfson Research Institute (WRI) brings together and develops a wide range of research on human health and wellbeing across the natural and social sciences and the humanities. Over 130 WRI Fellows from ten academic departments are pioneering new interdisciplinary approaches, from the role of primary care and public health in tackling health inequalities to the new intellectual field of medical humanities.

The Institute occupies a striking purpose-built waterfront building at the University’s Queen’s Campus Stockton which is being developed to generate new educational and economic opportunities in the Tees Valley. The Institute combines its commitment to world class research with strong partnerships with public services, health and regeneration agencies in North East England, particularly the NHS. These focus on applied research and developing new products and tools to improve health and quality of life, especially among disadvantaged groups where there is most potential to make a difference. www.durham.ac.uk/wolfson.institute

Sharing our knowledge We proactively protect IPR generated by research and currently have interests in over 70 discrete patent families. Healthcare and Life Sciences represent a significant proportion of our portfolio. Projects are taken forward as spin out companies, licensing deals or industrial collaborations.

Durham spin outs operating within the life sciences sector include: Reinnervate (www.reinnervate.com), Creative Gene Technology Ltd (www.creativegenetech.com), Fscan (www.fscanltd.com), Surface Innovations (www.surface-innovations.com) and Stem Cell Technologies which is developing skin regeneration technology with applications in advanced wound care, cosmetic and pharma development markets.

Fig 5: The component of the central spindle zone MAP65 (shown in red) supports microtubule organisation (green) required for chromosome separation (blue) and cell division during mitosis.

We are actively seeking companies looking to access technologies through: n collaboration or licensing n investors seeking exciting high growth opportunities n biotech managers wishing to engage in our spin out activity.

Fig 3: Professor Stefan Przyborski (above), founder of Durham University spin-out company ‘Reinnervate Limited’ showing three dimensional cell culture.

Licensing opportunities currently being pursued include; n An improved Microgripper for cell manipulation n A point of care diagnosis of Cystic Fibrosis n An electrochemical method to determine the chirality of drug

IN THE 2008 RESEARCH ASSESSMENT EXERCISE 90% OF OUR RESEARCH WAS DEEMED OF INTERNATIONAL QUALITY, WITH 78% EITHER INTERNATIONALLY “EXCELLENT” OR “WORLD LEADING”.

The University’s consultancy units routinely work with businesses in North East England, the UK and world wide to improve competitiveness and results in both the public and private sectors. We have an extensive range of state-of-the-art analytical equipment and facilities based in Science and Social Sciences and Health faculties which can be accessed by businesses and other organisations.

Durham University also offers a range of opportunities for working with businesses in research and our graduates and postgraduates are recruited by businesses throughout the world. Knowledge Transfer Partnership (KTP) grants can provide an ideal way of working on a specific project with the involvement of a graduate and in collaboration with the University.

precursors n Strategies for providing specific, safe and broad-spectrum

antiprotozoal drugs for diseases including Leishmaniases, African Sleeping Sickness, Chagas’ disease and Toxoplasmosis n A process for achieving the most stable polymorphic state (drug development) n Routes to enhanced yield of bioethanol

Fig 6: Visualisation of microfilaments in tobacco BY-2 tissue culture cell.

If you need to develop your employees with a tailor made course contact our Higher Level Skills Development Officer to discuss how we can help you. We can help through our North East Higher Skills Pathfinder project which aims to promote employer engagement in higher education by developing learning that meets the needs of employers.

To find out more about our services and how we can help you please contact us: Fig 4: Microtubules in pavement leaf cells control the development of elaborate cell’s shape.

www.durham.ac.uk/technology.transfer www.durham.ac.uk

W W W . C E L S G R O U P. C O M 6 1

INCUBATOR

a unique community...

...where brilliant ideas grow.

NETPark Incubator is managed by:

The NETPark Incubator offers more than just space to work, it is a total-support community in which science and technology businesses can develop and grow.

If your business idea is based on the research, design and development of new technologies, and has the potential and ambition to grow through innovation, then why not join us? If you have an innovation to develop, we’ll help you turn it into a business.

To find out more, visit us at:

www.uknetpark.net/incubator

Supported by:

Or contact us at: The NETPark Incubator Thomas Wright Way, Sedgefield, County Durham TS21 3FD

e-mail: netpark@wherebusinessgrows.com Project Part-Financed by the European Union European Regional Development Fund

NETPark enquiries: +44 (0)1740 625180

county durham... where science grows.

be well, connected

Driving the business of life sciences

M E D I C A L D E V I C E S F E AT U R E

D R A M AT I C D E V E L O P M E N T S W H I C H H E L P PAT I E N T S

Few fields of research have made as much technological advancement, or changed for the better so many lives, as that covering the area of medical devices instrumentation.

By using devices capable of complex calculation and analysis, researchers have been able to make massive leaps forward in their understanding.

Even thirty or forty years ago, the treatment and research of illnesses remained a relatively primitive sector compared with the stunning advances made since then.

Helping to drive the sector are companies who specialise in developing and improving the instrumentation to even further improve medical practice.

They key to many of the changes has been the advent of the computer digital technology, which has allowed medical practitioners to become much more effective in the way they work.

Their engineers are involved in nearly every aspect of medical and biological research, either as a part of a team with medical professionals or working independently.

Allied to other scientific disciplines, such as the rapid development of nanotechnology, the result has been a wide variety of instrumentation is available to the physician and surgeon to further the diagnosis and treatment of diseases and other problems within the body.

A significant role for medical engineers in research is the development of mathematical models of physiological and biological systems.

A major objective in the development of medical instrumentation has been to obtain the required results with minimal invasion, thereby making life easier for patients.

There has been a big move in recent years towards procedures which avoid entering the body and medical devices are playing a crucial role in making that happen.

By using computer technology, engineers have been able to create a wide range of devices, everything from handheld devices which allow paramedics to better check patients’ conditions at the scene to those which allow rapid diagnosis within hospitals.

In addition to better treatment, the combined application of engineering principles and computer techniques has had a significant impact on medical and biological research aimed at finding cures for a large number of diseases, such as heart disease, cancer, and AIDS.

6 4 C E L S H E A LT H C O N N E C T

Such work provides better understanding by coming up with ways to replicate natural functions they represent, allowing medical practitioners to increase their knowledge in order to treat patients or further research.

Such knowledge would have taken huge amounts of time to acquire a few decades ago - and in some cases, would have been out of reach altogether.

Among the many areas which are seeing major advances is the design and development of artificial organs and prosthetic devices.

A major goal in this area is to develop small, self-contained, implantable artificial organs that function as well as the natural ones.

The goal of such engineering is to increase the quality of life for the disabled, either by replacing lost functions or strengthening existing but weakened motor functions within the body, allowing people to live more normal lives.

Such work has given new hope to many people suffering from a wide range of afflictions: suddenly, a normal life seems within their reach.

With the business world the way it is, it’s hard to think beyond just surviving. But it’s more important than ever to focus on strategies that will help your business survive today’s problems and prepare for increased competitiveness when times get better. Continuing to look for ways to develop and bring new products to market, and to develop your processes to make your business leaner and smarter, is one of the best ways of making sure your company can be as recession-proof as possible. Which is exactly why County Durham Development Company has developed NETPark Net.

With links to the research facilities of the region’s five universities, venture capitalists, intellectual property specialists and more, NETPark Net means that innovative companies in the North East can tap into our extensive knowledge network, from as little as £99 a year.

So to take a big step towards greater competitiveness today, visit:

www.uknetpark.net/join and join our knowledge network.

county durham. where science grows NetPark Net enquiries: 01740 625180 e-mail: join@uknetpark.net

The NETPark Net project is part financed by the European Union’s ERDF Competitiveness programme 2007-13, securing £0.22m of ERDF investment through the Regional Development Agency One North East. The ERDF programme is bringing over £250m into the North East to support innovation, enterprise and business support across the region.

This project has received funding from Durham County Council through County Durham Development Company.

where business grows

WHO ARE WE? Bioinnovel provide innovative in-line rheology sensors with integrated process diagnostic and optimal control software measuring the mechanical properties of bio-cultures. Its technology can have a significant impact on the bio-pharmaceutical development process. It can increase productivity and reduce costs in the fast-growing biotech industry.

Bioinnovel was founded by Dr J. Vlahopoulou, a fermentation mechanics specialist who has extensively studied the effects of rheology in the optimisation of industrial fermentation.

“Bioinnovel’s mission is to become a leading provider of innovative bioprocess performance monitoring and optimal control software systems.

Optimal control is the new buzzword for success in the bio-industry. It aligns with the concept of Quality by Design. This means that we can now design the bio-process performance characteristics using first principles, and not the empirically derived interpretation of historical data.

Dr J. Vlahopoulou

By relating physical and biological parameters, and applying hybrid modelling techniques Bioinnovel proposes to increase productivity as the bio-industry scales up from the laboratory to the pilot plant and into production“.

END-USER BENEFITS Our proven, “intelligent” hardware and software allow the end-user to accurately monitor and control a range of biotechnology processes. The bio-manufacturing plants can now achieve consistent production, reduce production costs by 40%, avoid high failure rates, and improve yields by 10% .

The system can be customised to end-user requirements to achieve efficiencies in terms of time and cost. The architecture of our software modules enables tailor made solutions to suit individual process specifications. Our customers can achieve effective process control and optimisation for new bio-active compounds which are currently costing a lot more than they should to develop & commercialise. Using our technology, manufacturers can now accelerate the scale up of new biopharmaceuticals from the Phase III clinical trials to production. They will be now able to

OUR TECHNOLOGY During the course of a bio-process, i.e. fermentation, the dynamic biological cells behave as a colloidal suspension undergoing physical changes such as clumping, aggregation, cross-linking and branching or forming extra-cellular polymers.

These changes can be described in terms of colloidal and rheological parameters such as the suspension viscosity as well as the density, volume fraction/concentration, radius and elastic modulus of the bio-particles. These variables are more sensitive

For more information Tel: 0191-243-0876 & 0191-243-0683 Fax: 0191-222-3528 E-mail: info@bioinnovel.com www.b

In-situ rheology probes: Propagate ultrasonic waves through the flowing culture broth.

The wave is transmitted directly into the sample, and as it travels through the growing and dividing biological cells of the suspension within a fixed path length, its amplitude is attenuated.

Take real-time acoustic measurements and convert them to rheological and bio-colloid properties.

Bio-process performance monitoring software: Recognises critical states of the process by assessing the real-time physiological state of the dynamic bio-culture.

Prevents process underperformance by predicting complex variables such as productive morphologies, cell-cell interactions, optimum gene expression.

Instructs industrial controllers to take corrective actions.

indicators of the “critical quality” of the cell culture, and hence give a more accurate growth profile of the bioculture than conventional light scattering techniques.

By combining hybrid modeling and artificial intelligence techniques, we can relate the bio-colloid profiles to kinetic and metabolic activity of the bio-population at the various stages of the cell life cycle.

Achieving optimum mass transfer is one of the major bottlenecks in bioprocess scale-up, and optimisation. It is greatly influenced by the rheological properties of the broth, e.g. Newtonian or visco-elastic fluids.

The rheological properties of fermentation broths depend on biomass concentration (volume fraction, growth rate), cell-cell interactions (morphology, aggregation, cell-wall elasticity), and presence of bio-polymers.

Hence, they can be used as reliable indicators of bioprocess performance because they can detect: i) changes in the behaviour of biomass at different inoculum scale up stages, ii) the cell-cell interactions of broth suspensionss (mammalian, fungal cells). iii) transient states during the exponential & stationary growth phases

WHY USE RHEOLOGY n

Gives information on the mechanical behaviour of colloid particles (cells, polymers) upon stress and shear

n

Describes the contribution of particles to the suspension, e.g. density, increase in viscosity

n

Gives information on the structure of the colloid suspension

ACTIVE ULTRASOUND WAVES IN BIOLOGICAL COLLOIDS Cause damping or Attenuation of the wave amplitude which is:

bioinnovel.com

Not sensitive to chemical changes

n

Very sensitive to particle size, density and interactions

n

Ideal for monitoring bio-processes

Damping or Attenuation Concentration Sensitivity & Time dependence-Bioinnovel’s own real-time measurements using cellulose solutions fig-1, and during E.coli fermentation fig-2 Particle Size sensitivity Theory can handle polydisperse suspensions Challis, Tebbutt and Holmes, J. Phys. D: Appl. Phys. 31, 3481–3497 (1998).

OUR HISTORY

Fig 5b - Cellulose

3

900 Attenuation Coefficient (dB/m)

Bioinnovel was founded as a company dedicated to bio-processing technology and was later based in the Babraham Research Campus in Cambridge. In May 2006, Bioinnovel was awarded a Research Grant by the East of England Development Agency (EEDA), and completed the proof of concept phase, built a bench top model of its sensing probe and applied for a UK patent in April 2007, and a PCT in April 2008. In November 2008, Bioinnovel relocated to Newcastle Upon Tyne, and received investment from the Three Pillars Fund by North East Finance Ltd. It is now based in the INEX Business Incubator of the University of Newcastle.

n

800

Attenuation Coefficient (dB)

OUR PRODUCTS

FERMENTATION RHEOLOGY

700 600 500 400 300 200 100 0 0%

5%

10%

15%

20%

Concentration 1st Set 2nd Set

fig-1

25%

30%

35%

2.5 2 1.5 1 0.5 0 0

5

10

15

20

25

30

Time (Hours)

fig-2

35

40

45

50

CHALLENGING STEREOTYPES – B O Y S I N H E A LT H C A R E

Male students from the North East were given the opportunity to challenge the stereotypes of men working in healthcare.

This exciting day, held at the Close House Hotel, Northumberland in November, was attended by 36 Year 9 boys from Whickham, Cardinal Hume and St Thomas More Schools in Gateshead and male staff from local healthcare organisations.

The event was organised and facilitated by the Skills Academy for Health: STEPS with funding from Gateshead Council. The aim of the event was to challenge young people’s preconceptions surrounding careers in healthcare for men.

The day’s events began with a morning of various sector-related activities. ‘An Introduction to Stereotyping’ was the first activity to challenge the boys’ current views on typical jobs that men might take. This was followed by a Treasure Hunt which got the students running about the grounds of Close House to find clues describing the skills, qualities and main areas of work related to healthcare jobs. The students also completed a ‘Patient’s Journey’ activity. The first part of this activity introduced them to a wide range of new careers from Porter to Phlebotomist and Vascular Surgeon. In the second part of the activity, they were given three scenarios and had to identify the different healthcare professionals that a patient might come across between the reporting of the incident and them being recovered.

During the afternoon session, the students met with professionals to gain a better

6 8 C E L S H E A LT H C O N N E C T

knowledge and understanding of their respective job roles, the skills involved and the career paths leading to these careers.

“The highlight of the day was the boys meeting the male workers, and being able to openly ask questions and receive answers.

All my boys thoroughly enjoyed the day. We still have too many boys and girls who only consider traditional paths of employment.”

The first professionals they met were Dental Technicians, Christopher Dodd and Peter Harrison from Newcastle Dental Hospital. The students did not know the job roles of the professionals they were speaking to and had five minutes to question the professionals and guess their job role. The Dental Technicians brought numerous props with them to aid the students’ learning such as example dentures,

tooth impressions, and even prosthetic eyes and ears.

They also met Peter Fenwick, a Nurse from Northumbria Healthcare who discussed the various roles of men within the health service, some of the students were surprised to meet a man working as a nurse. Peter said that ‘I found the full experience quite enjoyable.

I’m quite open minded so their wasn’t really anything that surprised me, I suppose the only thing I was surprised at was the fact they jumped from doctor/dentist to clerical/porter and nurse was a last ditched guess, also no one knew about male physiotherapists or occupational therapists. That being said, I got the impression that some of the boys seemed genuinely interested in this career pathway.’

Finally, the students met with Histologists, Robert Hodgson and Anthony Abladey who told them about the role that Biomedical Scientists play in helping Doctors diagnose patients and assigned the appropriate treatment. They were informed of the stringent measures in place that ensure patient information is not mishandled, as well as the close relationship between Biomedical Scientists and GP services. The educational routes into Biomedical Science were also presented to them, with great emphasis placed on the choice of a clinical placement. Anthony Abladey had this to say: ‘At the event, despite the young men not knowing much about Biomedical Scientists and Histology, they were very attentive and somewhat encouraged by the important contribution Biomedical Scientists make in

the diagnosis and treatment of patients. The whole day was a great success and it was a pleasure sharing my knowledge with such enthusiastic young men.’

Glenda Hudson, Head of Health & Social Care at Cardinal Hume School in Gateshead, said about the event: “The highlight of the day was the boys meeting the male workers, and being able to openly ask questions and receive answers. All my boys thoroughly enjoyed the day. We still have too many boys and girls who only consider traditional paths of employment.”

Skills Academy for Health: STEPS is part of Skills for Health which is the Sector Skills Council for the UK. STEPS deliver a series of programmes engaging young people across the North East. They are particularly focused on the Young Apprenticeship and Society Health Diploma programmes where the 14-16 years old must complete 50 days of work based learning on top of their school studies. They also promote the healthcare sector to young people who are Not in Employment, Education or Training. Through the various programmes they run, STEPS seek to help young people to make informed career decisions. www.skillsacademyforhealth.org.uk

W W W . C E L S G R O U P. C O M 6 9

The Company began trading in April 2009, formed by Paul Graham and Indira Walker, both highly experienced QP’s. Paul and Indira had worked together previously, 15 years ago, when they were both employed by a large Pharmaceutical Company. They remained in contact despite moving to other companies in different parts of the country, while both progressing in their careers.

When the opportunity presented itself where they could work together in a Company of their own making, it was an exciting prospect. It has proved to be a winning combination so far, with an amalgamation of a broad spectrum of expertise which can be utilised to the advantage of our clients.

Both possess similar interpersonal skills, being approachable and easy to work with, they are able to rapidly build good working relationships with clients.

After two months of trading, as the client numbers increased and more projects were won, Beverley Graham and Andrew Walker joined the Company; Beverley holds a BSc in Chemistr y and has a broad experience in the Pharmaceutical industr y with companies including Glaxo, Pitman Moore, a CMO and Sterling Winthrop while Andrew has a BA, a commercial background and a legal qualification.

Paul has an MSc in Analytical Chemistr y, is a chartered chemist and Fellow of the Royal Society of Chemistr y. With over 25 years experience in the Pharmaceutical business he is a QP (through the permanent provisions) with companies such as MSD, Glaxo, Sanofi Aventis and a specialist CMO. Indira has a BSc in Chemistr y, is a chartered chemist and a member of TOPRA, has 20 years experience and is also a QP (through the permanent provision) holding senior positions in QA and Regulator y Affairs with US, EU and Japanese companies including Glaxo, Pharmacia and Daiichi.

From left to right: Andrew Walker, Indira Walker, Paul Graham and Bev Graham.

Following nine months of trading we have achieved a substantial turnover and have established a broad client base, including innovative SMEs seeking regulatory and quality advice, and CMOs and biotechnology companies who require advice on various quality initiatives and interim management positions. In addition, several clients have now revisited, requesting our support with new and additional projects.

The company is well networked with GCP quality experts, Microbiologists, Analytical Chemists and an expert in Human Error.

We are looking to expand further by hand picking associate QPs, who we know to share the same work ethos and who complete work in the same manner and to the same standard as ourselves.

The success, so far of the company has been recently highlighted by the nomination and

subsequent short listing to the last four, for the ERBI Business Start-Up Award.

As well as supplying quality advice we value good business advice, from the likes of David Molian, who is involved with entrepreneurship education at Cranfield University and with whom we meet regularly.

Recently we have exhibited at Liverpool, at the Medicines for Children Research Network conference and the Genesis exhibition in London.

Should you wish to learn more about our company we have a website which describes the services we offer, how to contact us and a free news letter subscription. In addition, you can also see the Walker Graham team.

info@walker-graham.com www.walker-graham.com

Services: Our service offerings include n Quality and Regulatory Consultation Services n Qualified Person on Manufacturer’s/Importer’s IMP and Commercial Licences n Pharma Human Error Risk Reduction n Responsible Person on Wholesaler Dealer’s Licence

n Supplier and Contractor GMP Auditing n Pharmaceutical Training n Trainee QP/RP Mentoring n Quality Risk Management n QP Emergency Response Consultation

be well, connected

Driving the business of life sciences

A S S O C I AT E S

A B

P R O T E O M I C S FBrewin U TDolphin URE OF BIOTECHNOLOGY

C D E

ADDRESS: Time Central Gallowgate Newcastle upon Tyne POSTCODE: NE1 4SR WEB: www.brewin.co.uk

F

CONTACT: Chris Glasper JOB ROLE: Analyst, Equity Research

Our investment banking team is dedicated to supporting smaller public companies and the mid-market. By combining the skills and knowledge of corporate advisory, equity research and equity sales and trading specialists, we are able to offer a fully integrated service to our clients that enables them to achieve their goals.

EMAIL: chris.glasper@brewin.co.uk TEL: 08450 596542 FAX: 08450 596788

G British Red Cross

H I

J K L M N O P Q R S T U V W X Y Z

ADDRESS: Fundraising Department Croft House Western Avenue Newcastle upon Tyne POSTCODE: NE4 8SR WEB: www.redcross.org.uk

CONTACT: Sasima Pearce JOB ROLE: Area Fundraising Manager North East and Cumbria TEL: 0191 2737961 FAX: 01228 558977

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

The British Red Cross is a volunteer-led humanitarian organisation that helps people in crisis, whoever and wherever they are. We enable vulnerable people at home and overseas to prepare for and respond to emergencies in their own communities. When the crisis is over, we help people recover and move on with their lives.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit healthy cell fromLtd those in a Captivu diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: Suite 1.5 a small number of proteins are separated out be a symptom of the disease, in which case Howard House Commercial from all other proteins in Centre the cell or organism they could help diagnose the disease much Howard Street and studied in great detail.

Although this earlier, and thus improve the prognosis for North Shields approach remains very valuable it misses out the patient, or the different proteins may be Tyne and Wear some important information. do not the cause of the disease, in which case they NE30Proteins 1AR POSTCODE: Captivuagainst specialises in information for healthcare These from exist in isolation from each other, so although could act as targets which new drugs systems Of course much ofapplications. this was promised www.captivu.com include: WEB: removes studying pure proteins interference can be developed. the earliest days of proteomics, and it has from other proteins it alsoMrreduces a lot of the to be said Simon Green • Information screens for healthcare waiting areasthe results so far have not lived CONTACT: • Interactive healthcare education systems, forThis children

JOBinteraction ROLE: Director complexity and which is actually a up to particularly expectations. is in part because • Patient interaction via web and mobile key part of how proteins work. theplatforms technology has had to catch up with EMAIL: info@captivu.com the Some of thesoftware equipment used for Captivu provides a full range of services in theory. this field, including Proteomics aims toTEL: redress by embracing proteomics, such as high resolution mass 0191this 2579156 development, provision of hardware, installation and maintenance. the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately CBSL (Cels Business Services Ltd) ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Quorum 16 to map out all the proteins in any Business given cellPark or handle the immensely large and complex data Quorum Benton organism, at a given time.

Once Lane you can do generated by this research has also increased upon Tyne this it enables you to trulyNewcastle understand how the exponentially over the decade, and finally, but POSTCODE: NE12 8BX chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect WEB: www.cbsl-uk.com CBSL provides consultancy services to support start-up and existing companies, In a way, the genome is rather like a dictionary new the techniques and methods to allow them universities and public sector clients across UK. Specialists in healthcare CONTACT: Mike Nicholds and life sciences, CBSL has an excellent track record of interpret delivering consultancy which contains a list of all the possible words to generate and robust reliable data.

JOB ROLE: Managing Director services to clients in the private and public sector based on the wealth of in a language, whereas the proteome is more expertise in the commercialisation of life science and healthcare technology. enquiries@cbsl-uk.com like the individualEMAIL: books in that language, Since differentWith cellatypes can be characterised In many ways proteomics has finally caught strong team of consultants focussing on the North East of England and

these do not contain all the words, only those by their own unique proteome fingerprint, upcollective with itself,experience that is not of to working say thereacross are no Scotland, CBSL draws on over 100 years’ TEL: 0191 215 5025 sectors including industry, thechallenges NHS in areas of innovation needed to tell the story, proteomics can be used to study how academia and more to overcome, butand we are 0191the 215way 5125in which FAX: and commercialisation, project evaluation, economic development, research and those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to technology transfer. is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

7 2 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Cicada Communications Ltd

B

ADDRESS: 101 Station Parade Harrogate North Yorkshire POSTCODE: HG1 1HB

C

WEB: www.cicada-comms.com

CONTACT: Lizzie Wilson JOB ROLE: Senior Account Manager EMAIL: lizzie@cicada-comms.com

Cicada Communications has over 20 years’ experience in managing the reputation of organisations both regionally and nationally. A B2B specialist, Cicada has strength in the healthcare, life sciences and investment sectors and has developed a sound network of the key regional, national, trade and online journalists

TEL: 01423 567111 FAX: 01423 565660

D E F G

Clicksquared

WEB: www.clicksquared.uk.com

CONTACT: Andrew Campbell JOB ROLE: Managing Director, UK EMAIL: andrew.campbell@ clicksquared.uk.com

H

ADDRESS: 3 Stratforth Road Riverside Road Riverside Park Middlesbrough Cleveland POSTCODE: TS2 1PJ

I J We are innovative technology driven ‘marketing/customer’ data analysts, transforming data into understanding and strategy. Within the health care sector, we have 3 areas of specialism: Public consultations, maximising patientservice relationships around DNA rates, specific disease areas such as STD, and profiling and segmenting medical catchment areas for optimal patient and clinic outcomes.

NEPAF (the North East Proteome Analysis Through Cels, NEPAF has a dedicated 01642 TEL: with Facility) will work a 808888 wide range of research team of six scientists, including experienced 249049 FAX: 01642 and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and will provide Durham Dr GlenDevelopment Kemp , project manager, NEPAF County Company (CDDC) them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art ADDRESS: The Rivergreen Centre facilities that allow even the smallest of Aykley Heads The facility will give clients access to expertise companies to carry out the research they County Durham DH1 5TS for drug discovery, POSTCODE: in the use of proteomics need. NEPAF’s goal is to support companies development and manufacture and in the carrying out significant and, in some cases, WEB: www.wherebusinessgrows.com diagnosis and monitoring of disease. ground-breaking research and development www.uknetpark.net using CDDC proteomics that will secure the is Durham County Council’s business development and inward investment Catherine arm. Responsible managing and to promoting NETPark, the North East’s CONTACT: The facility provides a rangeJohns of services reputation of the North for East as the place Science, Engineering and Technology Park. NETPark continues to be developed includingEMAIL: protein john.hildreth@duham.gov.uk extraction, using one of the do biotech business.” to encourage the commercialisation of Research & Development - to turn first pressure cycling homogenisers in the UK, Achiminnovative Treumann, scientific manager products. of ideas into successful 3708695 TEL: 0191 protein separation using 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and commercial research. The level Disability North different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable ADDRESS: The Dene Centre capabilities for biomarker discovery, signal results and our scientists’ communication Castle Farm Road transduction pathway analysis, protein skills ensure that you will understand them. ” Newcastle upon Tyne NE3 protein 1PH POSTCODE: expression analysis, identification, quantification and characterisation.

For further information visit: WEB: www.disabilitynorth.org.uk www.nepaf.com Terry Mallon Disability North is a user led regional charity with a constitutional majority of With CONTACT: its main laboratory located on the Chief University Executive Officer disabled people on its Executive Committee. The organisation aims to promote JOBof ROLE: campus Newcastle and a inclusion, independence and choice for disabled people. The wide range second laboratory located on the campus of of services available include information and advice on benefits, assistive EMAIL: reception@disabilitynorth.org.uk equipment and adaptations, accessible environments, disability awareness Durham University, NEPAF is supported by 0191 2840480 training, independent living, direct payments and support for carers and parents. the regionalTEL: development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 7 3

A B

P R O T E O Enterprise M I CEurope S FNetwork U T(EEN) UR E East England – North OF BIOTECHNOLOGY

C D E F

ADDRESS: PETEC NETPark Thomas Wright Way Sedgefield POSTCODE: TS21 3FG

WEB: www.een-northeast.co.uk.

CONTACT: Gillian Kears JOB ROLE: Business Innovation Manager EMAIL: gillian.kears@cenamps.com

At EEN we help regional business to: - Identify sources of finance - Shape R&D projects and build consortia - Connect seekers and providers of new technologies - Source R&D funds including FP7 and Grant for R&D - Provide FP7 coaching, advice and full assistance - Find potential suppliers for SMEs - Facilitate Healthcare & R&D related open consultations on behalf of the European Commission

TEL: 01740 625780 FAX: 01740 625792

G Finance Tree

H

I J

WEB: www.financetree.biz

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: Newcastle Business Village 33 Bellingham Drive Tyne Industrial Estate Newcastle upon Tyne POSTCODE: NE12 9SZ

CONTACT: Jonathan Gold JOB ROLE: Director

Finance Tree works with entrepreneurs and businesses looking to raise investment capital to develop their business plans, proposals and ultimately introduce them to investors. We also provide specialist training in finance venture capital and raising investment

EMAIL: j.gold@financetree.biz TEL: 0191 2705131

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit Frame healthy cellKirkland from those in a diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just www. framekirkland.com a small number ofWEB: proteins are separated out be a symptom of the disease, in which case from all otherCONTACT: proteins in David the cellBobs or organism they could help diagnose the disease much Partner

JOB ROLE: and studied in great detail.

Although this earlier, and thus improve the prognosis for approach remains very valuable it misses out the patient, or the different proteins may be EMAIL: dkb@framekirkland.com some important information. Proteins do not the cause of the disease, in which case they 01670 511102 TEL: exist in isolation from each other, so although could act as targets against which new drugs Of course much of this was promised from A training , development & consultancy company, with a record of delivering studying pure proteins removes interference can be developed. the earliest proteomics, and both general and more specialised skills training in days sales,of management and it has professional development. We supply technical to the from other proteins it also reduces a lot of the to be saidand the market results training so far have not lived UK healthcare and pharmaceutical sector. Our interventions are individually complexity and interaction which is actually a up to expectations. This is in part because enabling us to meet the training and development needs of a wide range of key part of how proteins work. the‘home’ technology has had to catch up with organisations both within and outside our sector the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Get More Time ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: South View to map out all the proteins inLane any given cell or handle the immensely large and complex data Old Long Marston organism, at a given time.

Once you can do generated by this research has also increased this it enables you to trulyYork understand how the exponentially over the decade, and finally, but POSTCODE: YO26 7NF chemical building blocks of life truly interact. perhaps most importantly, the people working Get More Time can help you whateverinyour within the medical or the involvement field have had to develop and perfect WEB: www.getmoretime.co.uk healthcare industry. We’re a marketing company who provide a fresh pair of In a way, the genome is rather like a dictionary new techniques and methods to allow them eyes to assess and create exciting opportunities for business. Your marketing CONTACT: Jason Wilson which contains a list of all the possible words to generate and interpret robust reliable data. campaigns will be transformed in to eye catching materials to grow or promote JOB ROLE: Managing Director your business. in a language, whereas the proteome is more info@getmoretime.co.uk like the individualEMAIL: books in that language, Since different cell types can be characterised In many ways proteomics has finally caught these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no TEL: 07518 387200 needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

7 4 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Grant Thornton

B

ADDRESS: Earl Grey House 75-85 Grey Street Newcastle upon Tyne POSTCODE: NE1 6EF

C

WEB: www.grant-thornton.co.uk TEL: 0191 2612631

We are proud to work with a long and varied list of clients. Within the public sector, we advise at all levels of the UK healthcare system from central government to regulators and providers, as well as clients in the social care sector.

In the private sector, our clients range from providers of primary and secondary care to private equity houses, care home providers and pharmaceutical and equipment suppliers.

D E F G

Horizonworks Marketing Ltd

WEB: www.horizonworks-marketing.co.uk

H

ADDRESS: The Quadrus Centre Woodstock Way Boldon Business Park Boldon Tyne & Wear POSTCODE: NE35 9PF

CONTACT: Samantha Davidson JOB ROLE: Managing Director

I J Horizonworks Marketing Ltd provides strategic marketing services that help you win new business, develop solid relationships and build a strong brand.

Specialising in the healthcare and life sciences sector, we create marketing strategies, implement plans, deliver successful projects and campaigns and can even act as your outsourced marketing department.

EMAIL: info@horizonworks-marketing.co.uk NEPAF (the North East Proteome Analysis Through Cels, NEPAF has a dedicated Our approach is simple – we help businesses get to where they want to be TEL: 0191 5197416 Facility) willFAX: work with a wide range of research team through of six scientists, experienced 0191 5197201 focussedincluding marketing.

and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

practitioners in the field of proteomics.

Dr Glen Kemp , project manager, Ignition Sales Ltd NEPAF says: “The UK’s biotechnology sector is growing and in order for this growth to art ADDRESS: PO Box 466 facilities that allow even the smallest of Gateshead The facility will give clients access to expertise companies to carry out the research they Tyne and Wear NE8 9DL for drug discovery, POSTCODE: in the use of proteomics need. NEPAF’s goal is to support companies development and manufacture and in the carrying out significant and, in some cases, WEB: www.ignitionsales.com diagnosis and monitoring of disease. ground-breaking research and development using Ignition proteomics secure Salesthat is a will leading UK the Business Development Company. The philosophy CONTACT: Ian Hamilton Director behind is to assist business JOB ROLE: The facility provides a range of services reputation of Ignition the North East asyour the place to to win new business. By working on a fixed monthly retainer, we provide a sales function thereby reducing the overall includingEMAIL: protein ianhamilton@ignitionsales.com extraction, using one of the do biotech business.” expense and legal implications of employing staff. first pressure cycling homogenisers in the UK, Achim Treumann, scientific manager of TEL: 07903 protein separation using714124 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic commercialLtd research.

The level Ithaka Life and Sciences (Ithaka) different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable ADDRESS: The NetPark Incubator capabilities for biomarker discovery, signal results and our scientists’ communication Thomas Wright Way transduction pathway analysis, protein skills ensure that you will understand them. ” NetPark Sedgefield expression analysis, protein identification, POSTCODE: TS21 3FD quantification and characterisation.

For further information visit: www.nepaf.com WEB: www.ithaka.co.uk Ithaka Life Sciences Ltd (Ithaka) was founded in 2000 and is a provider of business With its main laboratory located on the Dr John Adair and a advisory and interim management services to the life sciences sector specialising CONTACT: campus of Newcastle University in the commercialisation of technology. second laboratory located on the campus of EMAIL: john.adair@ithaka.co.uk We offer a regionally based service throughout England and Scotland with Durham University, NEPAF is supported by 01223 703146 consultants operating in Cambridge, Oxford and the South East, in the Midlands, the regionalTEL: development agency One North North East, North West and in Edinburgh, Scotland.

East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 7 5

A B

P R O T E O M I C SKite Innovation F U T (Europe) U R ELtd OF BIOTECHNOLOGY

C D

ADDRESS: Studio 1 The Media Centre Huddersfield West Yorkshire POSTCODE: HD1 1RL

WEB: www.kiteinnovation.com CONTACT: Derek MacKenzie

E

KITE Innovation was established in 2006 to help bridge the gap between the academic and business sectors in supporting collaboration, enterprise, and knowledge-based business development. KITE provides hands-on practical support to all types of initiatives in this business space. Always aiming to deliver high-value services that make a difference, KITE can provide innovative and flexible packages which buy in to the successful outcomes of the project.

TEL: 01484 437466

F G

Litmus Images UK Ltd

H I

J

WEB: www.litmus-images.com

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: 14 Stanhope Street Saltburn Cleveland POSTCODE: TS12 1AL

CONTACT: Dr Charles Twist JOB ROLE: Director EMAIL: charles.twist@litmus-images.com TEL: 01287 625865

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

Litmus Images UK Ltd, run by Charles Twist specialises in the photography of science and technology for industrial and commercial applications. Using a combination of traditional image capture and cutting-edge digital processes, we provide high quality images (i) of sites and buildings, pre-, during and postconstruction; and (ii) of manufacturing processes, personnel, equipment and products.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit healthy Consultancy cell from those in a Ltd Lyddallan diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: Wood Manor a small number of proteins are separated out be a symptom of the disease, in which case Wood Street from all other proteins in Shotley the cell Bridge or organism they could help diagnose the disease much County Durham and studied in great detail.

Although this earlier, and thus improve the prognosis for POSTCODE: DH8 0JE approach remains very valuable it misses out the patient, or the different proteins may be some important information. the cause of the disease, in which case they Lyddallan Consultancy offers technical and strategic services in the field of AndyProteins Lyddiattdo not CONTACT: bioprocess technology, underpinned by years much experience international Director JOBfrom ROLE: exist in isolation each other, so although could act as targets against which new drugs Of35 course of thisinwas promised from academic and corporate research, development and manufacture. studying pure proteins removes interference can be developed. the earliest days of proteomics, and it has EMAIL: al@lyddallan.co.uk from other proteins it also reduces a lot of the to be said theimplementation results so far have Practical skills available in the design, development, andnot lived

trouble-shooting of integrated bioprocesses the manufacture 583615 TEL: 01207 complexity and interaction which is actually a up to for expectations.

This isofinnatural part because and recombinant bioproducts (proteins, viruses, plasmids and cells). Innovative key part of how proteins work. the technology has had to catch up with approaches to technical problems and networked sources for customised the theory. Some of the equipment used for solutions are a specialty.

Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic Marketwise Strategies Ltd to discover more proteins, more accurately ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: 63 Westgate Road to map out all the proteins in any given cell or handle the immensely large and complex data Newcastle upon Tyne NE1 1SGyou can do organism, atPOSTCODE: a given time.

Once generated by this research has also increased this it enables you to truly understand how the exponentially over the decade, and finally, but WEB: www.marketwisestrategies.com chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect CONTACT: Jacquie Potts Director Marketwise Strategies is a market analysis strategy consultancy works

ROLE:is rather In a way, theJOB genome like a dictionary newand techniques and methodswhich to allow them extensively in the healthcare, science and technology markets, across the CONTACT: David Bain which contains a list of all the possible words to generate and interpret robust reliable data. public and private sectors. We offer a full range of qualitative and quantitative JOB ROLE: Senior Consultant in a language, whereas the proteome is more research methods to inform proof of concept, market entry/growth, branding info@marketwisestrategies.com perceptions studies. Our high quality research is supplemented like the individualEMAIL: books in that language, Since differentand cellstakeholder types can be characterised In many ways proteomics has finally caught by marketing strategy development. these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no TEL: 0191 2614426 needed to tell the story, way in which proteomics can be used to study how more challenges to overcome, but we are 0191the 2614426 FAX: and those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

7 6 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Marks & Clerk

B

ADDRESS: 5th Floor 14 South Parade Leeds POSTCODE: LS1 5QS

C

WEB: www.marks-clerk.com

Dr David Martin Patent Attorney Dr Paul Banford Partner

Marks & Clerk are the UK’s leading firm of Patent and Trade Mark Attorneys. We advise on intellectual property matters in variety of market sectors, with notable experience in bioscience, chemical, pharmaceutical, IT/software, electronics, mechanical and engineering.

EMAIL: leeds@marks-clerk.com

Our specialist Bioscience team has extensive experience in the drafting and prosecution of patent applications covering all aspects of life sciences. We are the HealthConnect preferred suppliers of Intellectual Property (IP) services.

CONTACT: JOB ROLE: CONTACT: JOB ROLE:

TEL: 0113 3895600 FAX: 0113 3895601 / 0161 2365846

D E F G

Murgitroyd & Company

H

ADDRESS: 2 Collingwood Street Newcastle Tyne and Wear POSTCODE: NE1 1JF

I J

WEB: www.murgitroyd.com

CONTACT: Claire Rutherford JOB ROLE: Patent Attorney EMAIL: calire.rutherford@murgitroyd.com

Among the largest and most progressive firms of European Patent and Trade Mark Attorneys, Murgitroyd & Company assist organisations in protecting their Intellectual Property rights. We have a reputation for providing practical, commercially relevant and technically accurate advice and place great emphasis on good service and resolving problems effectively.

TEL: 0191 2113550

NEPAF (theFAX: North0191 East2113551 Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

K L M

Dr Glen Kemp , project manager, NEPAF NETPark says: “The UK’s biotechnology sector is growing and in order for this growth to art ADDRESS: NETPark Incubator facilities that allow even the smallest of Thomas Wright Way The facility will give clients access to expertise companies to carry out the research they Sedgefield County Durham in the use of proteomics for drug discovery, need. NEPAF’s goal is to support companies 3FD POSTCODE: development andTS21 manufacture and in the carrying out significant and, in some cases, diagnosis and of disease. ground-breaking research and development www.wherebusinessgrows.com WEB:monitoring using NETPark proteomics willEast secure the www.uknetpark.net - Thethat North Technology Park - is one of the fastest growing science, engineering and technology The facility provides a range of services reputation of the North East as theparks placeintothe UK. NETPark’s sectoral focus is on the physical sciences, particularly plastic electronics, microelectronics, photonics, CONTACT: Catherine Johns - NETPark Net including protein extraction, using one of the do biotech business.” and their application in the fields of energy, defence, and nanotechnology, CONTACT: David Weddle - NETPark first pressure cycling homogenisers in the UK, Achimmedical-related Treumann, scientific manager of technologies.

EMAIL: david.weddle@netparkincubator. protein separation using 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use co.uk NETPark Net - is a virtual science park, enabling companies to access the Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions benefits of NETPark without being located there. multi-dimensional liquid625250 chromatography for real world biochemical problems. Our TEL: 01740 (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and commercial research.

NHS Innovations North The level different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable ADDRESS: RTC North capabilities for biomarker discovery, signal results and our scientists’ communication 1 Hylton Park Wessington Way transduction pathway analysis, protein skills ensure that you will understand them. ” Sunderland expression analysis, protein identification, Tyne and Wear quantification andSR5 characterisation.

For further information visit: 3HD POSTCODE: www.nepaf.com www.nhsinnovationsnorth.org.uk WEB: NHS Innovations North is the Intellectual Property Innovation Hub for the NHS With its main laboratory located on the in the North East. The team at NHS Innovations North have experience and campus of Newcastle University Dr Richard Hoareand a CONTACT: expertise in prior art exploration, market research and the commercialisation second laboratory located on the campus of Director JOB ROLE: process. This encompasses all aspects of NHS technology from identification of ideas through to appropriate protection and establishing licensing agreements.

Durham University, NEPAF is supported by EMAIL: enquiry@nhsinnovationsnorth.org.uk the regional development agency One North East and the European Regional Development 0191 5164400 TEL: 0191 5164401 FAX:Cels Fund. In 2007 secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 7 7

A B

P R O T E O M I C S North F UEast T Finance URE OF BIOTECHNOLOGY

C

ADDRESS: 1 St james Gate Newcastle upon Tyne POSTCODE: NE1 4AD

WEB: www.northeastfinance.org

D

CONTACT: Sarah Richards

North East Finance (formerly NStar) is responsible for the development of a range of innovative access to finance initiatives across North East England. Our primary role is to put in place venture capital, mezzanine and loan funds, targeted at high-growth small and medium-sized companies seeking investment finance.

TEL: 0191 2112300 FAX: 0191 2112323

E F G

Northern Recruitment Group plc (NRG)

H I J K L M N O P Q R S T U V W X Y Z

ADDRESS: Lloyds Court 56 Grey Street Newcastle upon Tyne POSTCODE: NE1 6AH WEB: www.nrgplc.com CONTACT: Patrick Lonergan JOB ROLE: Business Manager (Engineering & Scientific) EMAIL: patricklonergan@nrgplc.com TEL: 0191 2321222

The term Proteomics was only coined FAX: 0191 2618466 around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

NRG are the North East’s largest recruitment business. NRG is a national recruitment solutions company delivering bespoke recruitment services for over thirty years. NRG set out to provide quality recruitment services to both the private and public sectors.

NRG are a multidiscipline business of specialist teams dealing with levels of recruitment from industrial and clerical posts to specialist professional and

changing as itexecutive ages androles. even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit healthy cell from those in a Outmark diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: The Gables a small number of proteins are separated out be a symptom of the disease, in which case 7 Station Road from all other proteins in Beamish the cell or organism they could help diagnose the disease much County Durham and studied in great detail.

Although this earlier, and thus improve the prognosis for POSTCODE: DH9 QU approach remains very valuable it misses out the patient, or the different proteins may be some important information.

Proteins do not the cause of the disease, in which case they WEB: www.outmark.co.uk Outmark provides a flexible, dedicatedOf sales andmuch marketing resource. exist in isolation from each other, so although could act as targets against which new drugs course of this was promised from Sylvia Dickinson studying pureCONTACT: proteins removes interference can be developed. the earliest days of proteomics, and it has Use Outmark to:

JOB ROLE: Creative Partner from other proteins it also reduces a lot of the to bewith saidathe results so far have not lived • boost your sales and marketing capacity fresh outlook.

• give your database a lift and inject new lifeexpectations. and new market into EMAIL: sylvia@outmark.co.uk complexity and interaction which is actually a up to This opportunities is in part because your business. of how proteins work. key part the technology has had to catch up with • Establish a good foothold in the marketplace with the right customers in the TEL: 0191 3703536 / 07947 845141 the theory. Some of the equipment used for right area with the right purchasing power.

FAX: 0191 3703536 Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic Pitman Training - Middlesbroughto discover more proteins, more accurately ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to Cleveland Business Centre

ADDRESS: 1 Watson Streetcell or to map out all the proteins in any given handle the immensely large and complex data Middlesbrough organism, at a given time.

Once you can do generated by this research has also increased Cleveland this it enables you to truly understand how the exponentially over the decade, and finally, but POSTCODE: TS1 2RQ chemical building blocks of life truly interact. perhaps most importantly, the people working WEB: www.pitman-training.com/ in the field have had to develop and perfect middlesbrough Pitman Training have been developingnew people and organisations for over 165 them In a way, the genome is rather like a dictionary techniques and methods to allow years. With access to over 100 courses, we specialise in the delivery of office, which contains a list of allKevin the possible to generate and interpret robust reliable data.

Green words CONTACT: secretarial, computing and business skills. Our experience and flexibility means Centre Manager

JOB ROLE: the in a language, whereas proteome is more that we can deliver training individually or to larger groups like the individual books in that language, Since different cell types can be characterised In many ways proteomics has finally caught EMAIL: kevin.green@pitman-training.net these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no 01642 07825 566601 TEL: and needed to tell the story, the247485 way in/ which proteomics can be used to study how more challenges to overcome, but we are FAX: 01642 247485 those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

7 8 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Pitman Training - Newcastle

WEB: www.pitman-training.com/ newcastle

B

ADDRESS: 4th Floor 16-18 Hood Street Newcastle upon Tyne Tyne and Wear POSTCODE: NE1 6JQ

CONTACT: Dave Stevens JOB ROLE: Director EMAIL: dave.stevens@pitman-training.net TEL: 0191 2411122

C Pitman Training is one of the world’s best known names in Business and IT Skills training, delivering courses encompassing key office skills, book-keeping and IT Technical training.

Students work at their own individual pace using multimedia modules, linked to student workbooks. Pitman Training Newcastle is a Microsoft IT Academy and an authorised test centre for numerous qualifications, including AMSPAR, ECDL, OCR and AAT

D E F G

Public Knowledge Ltd

WEB: www.publicknowledge.eu CONTACT: Nicola Turnhill

H

ADDRESS: The Mill Hexham Business Park Burn Lane Hexham Northumberland POSTCODE: NE46 3RU

EMAIL: info@publilcknowledge.eu

I J Action based primary and secondary research relating to patient and customer trends, socio-economic, demographic, macro and community centered health research.

Market testing of new approaches and methodologies. Scenario planning and corrective action appraisals.

613273 NEPAF (the TEL: North01434 East Proteome Analysis Through Cels, NEPAF has a dedicated Pre-project planning and post project appraisals.

FAX: 01434 611161 Facility) will work with a wide range of research team of six scientists, including experienced and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and will provide Dr Glen Kemp , project manager, NEPAF RMT Accountants & Business Advisors them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art ADDRESS: Gosforth Park Avenue facilities that allow even the smallest of Newcastle upon Tyne The facility will give clients access to expertise companies to carry out the research they Tyne and Wear NE12 8EG POSTCODE: in the use of proteomics for drug discovery, need. NEPAF’s goal is to support companies development and manufacture and in the carrying out significant and, in some cases, WEB: www.r-m-t.co.uk diagnosis and monitoring of disease. ground-breaking research and development You know how it is. You’re halfway through the bit explaining what an using accountant proteomics or that will secure thecan do for you when your thoughts start drifting CONTACT: Matthew Flinders business advisor The facility provides a range of services reputation of the North Eastfor as supper the place to towards what to have tonight.

EMAIL: matthew.flinders@r-m-t.co.uk including protein extraction, using one of the do biotech business.”

Too much jargon, too many ‘what-ifs’, too many examples that don’t seem to first pressure cycling in the UK, Achimbear Treumann, scientific manager of 0191homogenisers 2569500 TEL: any relation to how you do business.

2569501 FAX: 0191 protein separation using 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use At edge RMT we promise something Gel Electrophoresis (2D-PAGE) and leading technology to provide different. solutions multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, includingSam six Hamilton academic and commercial research.

The level Ltd Medical Writing Services different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable ADDRESS: 20 Rokeby Drive capabilities for biomarker discovery, signal results and our scientists’ communication Newcastle upon Tyne transduction pathway analysis, protein skills ensure that you will understand them. ” NE3 4JX POSTCODE: expression analysis, protein identification, WEB: www.samhamiltonmw quantification and characterisation.

For further information visit: services.co.uk Samina Hamilton is a freelance medical writer. A postdoctoral virologist with www.nepaf.com clinical research experience since 1994, offering consultancy services to the Samina located Hamilton With CONTACT: its main laboratory on the pharmaceutical industry and trial investigators, ensuring documentation is prepared to ICH-GCP and regulatory standards. campus of Newcastle University and a EMAIL: sam@samhamiltonmw second laboratory located on the campus of services.co.uk Writing services include: Durham University, NEPAF is supported by • Clinical study protocols and amendments 0191 2843508 TEL: the regional development agency One North • Clinical study reports • Manuscripts for peer-review journals East and the European Regional Development • Standard Operating Procedures (SOPs) Fund. In 2007 Cels secured £4 million to • Tailored clinical research training packages. develop the facility, which is the only one of its kind in the North East of England.

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 7 9

A B

PROTEOMICS FU TU Sintons LLP R E OF BIOTECHNOLOGY

C

WEB: www.sintons.co.uk

D E

ADDRESS: The Cube Barrack Road Newcastle upon Tyne POSTCODE: NE4 6DB

CONTACT: Anthony Evans JOB ROLE: Partner

F

Sintons LLP is a leading commercial law firm in the North East of England.

Our dedicated healthcare group advise both private and public sector organisations in the healthcare and life science sectors. Drawing on commercial expertise from across the firm, the team deliver a bespoke service.

EMAIL: anthony.evans@sintons.co.uk TEL: 0191 2267878 FAX: 0191 2267850

G H

Surreal Creative

I J

WEB: www.surrealcreative.co.uk

K L M N O P Q R S T U V W X Y Z

ADDRESS: First Floor e-volve Business Centre Cygnet Way Rainton Bridge South Business Park Houghton-le-Spring Tyne and Wear POSTCODE: DH4 5QY

CONTACT: Ian Smith JOB ROLE: Managing Director EMAIL: ian@surrealcreative.co.uk

Surreal Creative is a full service creative, design and marketing agency that fully understands the vital importance of brand influence.

We are specialists in the compliance and requirements of the Disability Discrimination Act (DDA).

We have a wealth of experience in catering for specialist needs and individual

The term Proteomics was only coined changing as itDDA ages and even in response to to give us important insights in the ageing requirements.

0191 3055070 / 07768 507700 TEL: making around 14 years ago, it a relatively changes from outside and within. process as a whole. So there are scientific new science. It was developed to address questions proteomics can help us answer, a key limitation in classical protein For example if you could compare the literally from cradle to grave. biochemistry. proteins in aTeesside fit healthy cell University from those in a What is more, since proteomics can diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural

ADDRESS: Middlesbrough a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Tees Valley from all other proteins in TS1 the 3BA cell or organism they could help diagnose the disease much crops and more efficient biofuels, and in POSTCODE: and studied in great detail. Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to WEB: www.tees.ac.uk approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity. some important EMAIL: information.

Proteins do not the cause of the disease, in which case they enquries@tees.ac.uk Teessideagainst University is widely recognisedOf as course an enabling, exist in isolation from each other, so although could act as targets which new drugs much energetic, of this waspassionate promised from 01642 218121 and partnership focused institution - we are the Times Higher Education’s TEL: removes studying pure proteins interference can be developed. the earliest days of proteomics, and it has University of the Year. With nearly 28,000 students and over £120m recent campus from other proteins it also reduces a lot of the to be said thebusiness results so far have not lived investment Teesside inspires success in students and partnerships. complexity and interaction which is actually a up to expectations. This is in part because key part of how proteins work. the technology has had to catch up with the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately think M. Ltd ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: 6 Charlotte Square to map out all the proteins in any given cell or handle the immensely large and complex data Newcastle upon Tyne NE1 4XF you can do organism, atPOSTCODE: a given time.

Once generated by this research has also increased this it enables you to truly understand how the exponentially over the decade, and finally, but WEB: www.think-M.co.uk chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect CONTACT: Paul Sutherland Senior like Partner think M. is a strategic marketing and agile consultancy.

We offer a them

ROLE:is rather In a way, theJOB genome a dictionary newresearch techniques and methods to allow range of unique products and services supporting rapid and informed client which contains aEMAIL: list of allpaul@think-m.co.uk the possible words to generate and interpret robust reliable data. decision making and intelligent marketing activity. Whether you’re in the public in a language, whereas the proteome is more or private sector, we have developed a range of proven processes to help you

0191 plan, and manage marketing.

TEL: in like the individual books that2111957 language, Since differentresearch, cell types canimplement be characterised In strategic many ways proteomics has finally caught FAX: 0191 2111921 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

8 0 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Tipple Associates Ltd

WEB: www.tippleassociates.co.uk

B

ADDRESS: 45 Abbots Green Willington Crook County Durham POSTCODE: DL15 0QZ

CONTACT: Julie Tipple JOB ROLE: Director EMAIL: julie@tippleassociates.co.uk

C Tipple Associates Ltd provides companies with the essential extra capacity to investigate new product ideas, new technologies and sources of funding (Grant for Research And Development, NStar PoC, etc) for them. We work closely with a variety of technology organisations, development agencies and others We work mainly for established, successful businesses busy with day-to-day operations, but with the vision to require new product developments.

TEL: 0845 0046745

D E F G

UK Trade & Investment

WEB: www.uktradeinvest.gov.uk

H

ADDRESS: Regional International Trade Office Spectrum 6 Spectrum Business Park Seaham County Durham POSTCODE: SR7 7TT

CONTACT: Keith Stockdale JOB ROLE: North East International Trade Adviser

NEPAF (the Northkeith.stockdale@ukti.rito.co.uk East Proteome Analysis EMAIL: Facility) will work with a wide range of research 0505054 / 07810 644829 TEL: 0845 and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

I J The International Trade Advisers (ITAs) are experts in doing business overseas, every UK region has sector specialists who can provide advice tailored specifically to your company. Their role is to help you increase sales in overseas markets.

K

With UK Trade & Investment being located in Government its staff have an in-

L

depth knowledge of UK regional business and a global network, making a unique Through Cels, NEPAF has a dedicated strategic resource team of six scientists, including experienced practitioners in the field of proteomics.

Dr Glen Kemp , project manager, NEPAF Urban River says: “The UK’s biotechnology sector is growing and in order for this growth to art

ADDRESS: Urban River Creative Ltd facilities that allow even the smallest of Windsor Hall The facility will give clients access to expertise companies to carry out the research they Burrow Street South Shields in the use of proteomics for drug discovery, need. NEPAF’s goal is to support companies and Wearand in the development andTyne manufacture carrying out significant and, in some cases, POSTCODE: NE33 1PP diagnosis and monitoring of disease. ground-breaking research and development usingUrban proteomics thatan will secure the North East based full service branding, River are award winning WEB: www.urbanriver.com web and graphic Our The facility provides a range of services reputation of the North design East asagency. the place to services include branding, advertising and exhibition design, literature and direct mail design, website design and CONTACT: Carl Buckley including protein extraction, using one of the do biotech business.” development, ecommerce and e-marketing and design and build of interactive

JOB ROLE: Managing Director first pressure cycling homogenisers in the UK, AchimDVDs Treumann, scientific manager of and CDs. EMAIL: info@urbanriver.com protein separation using 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use We have a simple approach;

Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions TEL: 0191 4235688 multi-dimensional liquid chromatography for real world biochemical problems.

Ourwhich makes an impact.

Listen, create and implement work (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six andPharma commercial research.

The levelLtd Walker academic Graham Consulting different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable

ADDRESS: Bulman House capabilities for biomarker discovery, signal results and our scientists’ communication Regents Centre transduction pathway analysis, protein skills ensure that you will understand them. ” Gosforth upon Tyne expression analysis,Newcastle protein identification, POSTCODE: NE3 3LS quantification and characterisation.

For further information visit: www.nepaf.com WEB: www.walker-graham.com At Walker Graham Pharma Consulting Ltd we specialise in the provision of With its main laboratory located on the MrsUniversity Beverley Graham Quality Assurance and Regulatory services to pharmaceutical, medical campusCONTACT: of Newcastle and a device and healthcare sectors. Indira Walker and Paul Graham are two highly

JOB ROLE: Client Liaison Manager second laboratory located on the campus of experienced Qualified Persons dedicated to providing a range of QP solutions. bev@walker-graham.com We have Qualified Person, Responsible Person and Quality Management EMAIL: NEPAF Durham University, is supported by experience under Investigational Medicinal Product, Wholesale and Commercial regional development agency One North the pharmaceutical manufacturer’s licenses.

TEL: 01670 517631 East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 8 1

A B

P R O T E O M I C S Wood F UHolmes T UGroup RE OF BIOTECHNOLOGY

C D

ADDRESS: 17th Floor Cale Cross House 156 Pilgrim Street Newcastle upon Tyne Tyne and Wear POSTCODE: NE1 6SU

WEB: www.woodholmes.co.uk

E

F

CONTACT: Stuart Smith JOB ROLE: CEO EMAIL: contact@woodholmes.co.uk TEL: 0191 2112999

G H

Yellow Road

I J K L M N O P Q R S T U V W X Y Z

Wood Holmes are a strategy consultancy with offices in Newcastle, London, Manchester and Singapore. We help clients in understanding and making sense of complex environments. Our work includes, market mapping, business strategy development, business planning, technology fore sighting and sustainable development.

ADDRESS: 1 Armstrong Prestwick Park Ponteland Newcastle upon Tyne POSTCODE: NE20 9SJ WEB: www.yellowroad.co.uk

Yellow Road Limited is a project management and business development consultancy situated in the North East of England.

CONTACT: Mark Jarvis JOB ROLE: Managing Director EMAIL: mark.jarvis@yellowroad.co.uk TEL: 07733 261978

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

In the traditional approach a single protein or a small number of proteins are separated out from all other proteins in the cell or organism and studied in great detail. Although this approach remains very valuable it misses out some important information. Proteins do not exist in isolation from each other, so although studying pure proteins removes interference from other proteins it also reduces a lot of the complexity and interaction which is actually a key part of how proteins work.

Proteomics aims to redress this by embracing the complexity of a large number of different proteins in the same sample. Just as the human genome project allowed the genetic ‘plan’ of human beings to be deciphered, so proteomics, one day, aims to provide a means to map out all the proteins in any given cell or organism, at a given time. Once you can do this it enables you to truly understand how the chemical building blocks of life truly interact.

In a way, the genome is rather like a dictionary which contains a list of all the possible words in a language, whereas the proteome is more like the individual books in that language, these do not contain all the words, only those needed to tell the story, and the way in which those words interact dictates how the story is shaped, but unlike a book, the proteome is not fixed in time either, it is constantly

8 2 C E L S H E A LT H C O N N E C T

We work with industry, academia and the voluntary sector to secure sources of funding and new business contacts to develop innovative ideas. With particular expertise in science and technology we also have extensive experience in the management of complex public funded projects.

changing as it ages and even in response to changes from outside and within.

For example if you could compare the proteins in a fit healthy cell from those in a diseased cell, you will see some small but vital differences. These different proteins may just be a symptom of the disease, in which case they could help diagnose the disease much earlier, and thus improve the prognosis for the patient, or the different proteins may be the cause of the disease, in which case they could act as targets against which new drugs can be developed.

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

Since different cell types can be characterised by their own unique proteome fingerprint, proteomics can be used to study how embryonic stem cells can develop into any one of many different cell types, or it can look at the changes that occur in cells as they age

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

Of course much of this was promised from the earliest days of proteomics, and it has to be said the results so far have not lived up to expectations. This is in part because the technology has had to catch up with the theory. Some of the equipment used for proteomics, such as high resolution mass spectrometers, have improved greatly over the last decade, and now allow researchers to discover more proteins, more accurately and more quickly than ever before. The amount of computing power required to handle the immensely large and complex data generated by this research has also increased exponentially over the decade, and finally, but perhaps most importantly, the people working in the field have had to develop and perfect new techniques and methods to allow them to generate and interpret robust reliable data.

In many ways proteomics has finally caught up with itself, that is not to say there are no more challenges to overcome, but we are now in a better position than ever before to finally reap the rewards of this young and exciting field of science.

be well, connected

Driving the business of life sciences

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

The facility will give clients access to expertise in the use of proteomics for drug discovery, development and manufacture and in the diagnosis and monitoring of disease.

The facility provides a range of services including protein extraction, using one of the first pressure cycling homogenisers in the UK, protein separation using 2-D Polyacrylamide Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide capabilities for biomarker discovery, signal transduction pathway analysis, protein expression analysis, protein identification, quantification and characterisation.

With its main laboratory located on the campus of Newcastle University and a second laboratory located on the campus of Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

Dr Glen Kemp , project manager, NEPAF says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development using proteomics that will secure the reputation of the North East as the place to do biotech business.”

Achim Treumann, scientific manager of NEPAF says: “Our aim at NEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic and commercial research. The level of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com

ASSISTIVE TECHNOLOGY W W W . C E L S G R O U P. C O M 8 3

A B

P R O T E O M I C S Altonaids F U TMobility U RLtdE OF BIOTECHNOLOGY

C D

ADDRESS: 15 Hadrian Court Queensway South Team Valley Gateshead Tyne and Wear POSTCODE: NE11 0XW

WEB: www.altonaids.co.uk

E

F

CONTACT: Paul Armstrong JOB ROLE: Managing Director

Sales and service of mobility equipment and disability aids. Specialty in highend manual wheelchairs, powered wheelchairs, pediatric equipment and Vela working chairs. Based on the Team Valley Trading Estate, we cover the North of England. BHTA members and established in 1979. We have the largest selection of mobility equipment in the North East of England.

EMAIL: sales@altonaids.co.uk TEL: 0191 4915840 FAX: 0191 4876755

G Aquajoy Bathlifts Ltd

H I

J

WEB: www.aqua-joy.com

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: Consett Business Park Consett County Durham POSTCODE: DH8 6BN

CONTACT: Hugh Malone JOB ROLE: Managing Director EMAIL: info@aqua-joy.com TEL: 01207 501555 FAX: 01207 599789

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

Design, manufacture and sell a range of high quality bath lifts and accessories for both adults and children. Aqua Joy Bathlifts Ltd has established an enviable reputation for providing first class reliable products supported by unbeatable levels of customer support throughout the UK and Europe.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit healthy cellBros from those Bolton Ltdin a diseased cell, you will see some small but vital In the traditional approach a single protein Bolton House, PennorStreet differences. These different proteins may just ADDRESS: a small number of proteins are separated out Estate be a symptom of the disease, in which case Scotswood Industrial upon Tyne from all other proteins in Newcastle the cell or organism they could help diagnose the disease much POSTCODE: NE4 7BG and studied in great detail. Although this earlier, and thus improve the prognosis for approach remainsWEB: very valuable it misses out the patient, or the different proteins may be www.bolton-bros.co.uk some important information. Proteins do not the cause of the disease, in which case they CONTACT: Jonathan Bolton Bolton Bros.

Ltd which has been and supplying anpromised orthotic from exist in isolation from each other, so although could act as targets against newmanufacturing drugs Oforthoses course much of this was

JOB ROLE: Director service to clinics in the North East of England since the beginning of the National studying pureCONTACT: proteins removes interference can be developed. the earliest days of proteomics, and it has Ron Sharpe Health Service.

Director

JOB ROLE: from other proteins it alsoFinance reduces a lot of the to be said the results so far have not lived Bolton Bros’ manufactured stock orthoses carry the European mark. complexity and interaction which is actually a up now to expectations.

This is inCE part because EMAIL: ron@bolton-bros.co.uk Now the UK Service Centre for the repair MBT Footwear key part theoftechnology has (Masai had to Barefoot catch up with of how proteins work.

Technology) TEL: 0191 2732012 the theory. Some of the equipment used for 0191 2260143 FAX: Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Care-ability Healthcare ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: 6b Spire Road to map out all the proteins in anyIndustrial given cell or handle the immensely large and complex data Glover Estate Washington organism, at a given time.

Once you can do generated by this research has also increased and Wear this it enables you to trulyTyne understand how the exponentially over the decade, and finally, but POSTCODE: NE37 3ES chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect WEB: www.care-ability.co.uk Care-ability Healthcare supply, install, service, repair and manufacture widethem In a way, the genome is rather like a dictionary new techniques and methods toaallow range of moving and handling products for the healthcare industry. We offer a CONTACT: David Tilly which contains a list of all the possible words to generate and interpret robust reliable data. wide range of bespoke patient lifting slings plus various other products including JOB ROLE: Partner in a language, whereas the proteome is more mobile and ceiling hoists, profiling beds, riser recliner chairs etc. All products are david@care-ability.co.uk up by days and 24/7 service department. like the individualEMAIL: books in that language, Since differentbacked cell types canour be365 characterised In many ways proteomics has finally caught these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no TEL: 0191 4159777 needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

8 4 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

Centre for Rehabilitiation & Engineering Studies (CREST)

B

ADDRESS: Newcastle University Stephenson Building Newcastle upon Tyne Tyne and Wear POSTCODE: NE1 7RU WEB: www.ncl.ac.uk/crest CONTACT: Dr Tom Joyce TEL: 0191 2226213 FAX: 0191 2228600

A

C CREST is an inter-disciplinary research group, based at Newcastle University, with an established International reputation in clinical rehabilitation and bioengineering.

CREST’s primary interests are centered on the fields of: Upper limb biomechanics and assistive technology (Prof. Johnson) Joint replacement and biotribology (Dr. Joyce) Musculo-skeletal modeling and comparative biomechanics (Dr. Lawson)

D E F G

Disability Fitness

H

ADDRESS: Unit A, Foundry Yard Bellingham Northumberland POSTCODE: NE48 2DA

I J

WEB: www.disabilityfitness.com

CONTACT: Brian Turner JOB ROLE: Managing Director EMAIL: brian@disabilityfitness.com TEL: 01434 221161 / 07800 905541 NEPAF (theFAX: North01434 East 221161 Proteome Analysis

Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: Independence House Federation Way Lancaster Road, Dunston The facility will give clients access to expertise Tyne and Wear in the use of proteomics for drug discovery, POSTCODE: NE11 9JR

development and manufacture and in the www.easi-access.co.uk diagnosis WEB: and monitoring of disease.

CONTACT: Martin Cook Managing The facility JOB ROLE: provides a rangeDirector of services Heath CONTACT: including protein Nigel extraction, using one of the

JOB ROLE: Business Development Manager

first pressure cycling homogenisers in the UK, EMAIL: martin.cook@easibathe.com protein separation using 2-D Polyacrylamide

Gel Electrophoresis (2D-PAGE) and TEL: 07876 596069 / 07739 50400 / multi-dimensional0800 liquid chromatography 3217430 4602888can then be FAX: 0191proteins (MD-LC). Separated investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide

ADDRESS: 1 Saville Chamber capabilities for biomarker discovery, signal North Street transduction pathway analysis, protein Newcastle upon Tyne NE1 protein 8DF POSTCODE: expression analysis, identification, quantification and characterisation.

WEB: www.i2iwheelchairs.com

Basil Firth With CONTACT: its main laboratory located on the Director campus JOBof ROLE: Newcastle University and a second laboratory located on the campus of EMAIL: basil.firth@i2iwheelchairs.com Durham University, NEPAF is supported by 0191 2811294 the regionalTEL: development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

We specialise in the mail order of exercise equipment for the less able, catering for virtually all needs with products ranging from as little as £15.00 to top of the range commercial exercise equipment.

Some of the equipment has been developed by ourselves using our fitness centre catering for the disabled as our practical research centre with our range of exercise proving very popular.

Through Cels,DVD’s NEPAF has a dedicated

K L

team of six scientists, including experienced practitioners in the field of proteomics.

M

Dr Glen Kemp , project manager, Easibathe Ltd NEPAF says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development usingEasibathe proteomics secure Ltdthat is awill supplier of the specialist bathing, showering and hoisting equipment.

Easibathe integral reputation of the North Eastare as the placetotothe network of local authorities, healthcare professionals and private clients looking for advice, support and products. do biotech business.”

AchimEasiaccess Treumann,(division scientific of manager Easibatheof Limited) specialises in the manufacture and supply access are registered distributors of Excellent NEPAF says:of“Our aimequipment. at NEPAF isEasiaccess to use Systems products. leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic commercial research. The level i2iand Wheelchairs of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ”

N

For further information visit: www.nepaf.com

To design, develop, manufacture and sell products that will enhance the quality of life of wheelchair users.

To work with the best engineers, clinicians and other professionals to produce innovative products that meet the highest levels of engineering quality, integrity and excellence.

To strive to make products that are effective, stylish and affordable

O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 8 5

A B

P R O T E O M I C S F Lift UAble TU LtdR E OF BIOTECHNOLOGY

C D E F

ADDRESS: 2 Easter Park Teesside Industrial Estate Stockton on Tees Teesside POSTCODE: TS17 9NT WEB: www.liftable.co.uk

CONTACT: Tina Bell JOB ROLE: Sale Manager EMAIL: tina.bell@liftable.co.uk

Lift Able is a manufacturer and supplier of products, services and access solutions for the elderly and/or disabled in private dwellings and commercial or public buildings. It exports worldwide and is one of the largest suppliers of mobility equipment to the UK Publicly Funded Sector. Lift Able use only high quality components, to ensure each lift meets our stringent quality standards.

TEL: 01642 768590 FAX: 01642 766590

G MediTek

H I

J K L M N O P Q R S T U V W X Y Z

ADDRESS: Fishburn Industrial Estate Fishburn Durham POSTCODE: TS21 4AJ WEB: www.meditek.co.uk

EMAIL: sales@meditek.net TEL: 01740 623823 FAX: 01740 623823

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

MediTek is one of the UK’s leading manufacturers and suppliers of domestic stairlift and access solutions. Stylish aesthetics, innovation and superior product quality lie at the heart of the MediTek business ethos. All products meet current British and European standards MediTek is an active member of the Lift & Escalator Industry Association (LEIA) and The British Healthcare Trades Association (BHTA)

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins Middlesbrough in a fit healthy cell from those in a Council diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: Vancouver House a small number of proteins are separated out be a symptom of the disease, in which case Gurney Street from all other proteins in Middlesbrough the cell or organism they could help diagnose the disease much Teesside and studied in great detail.

Although this earlier, and thus improve the prognosis for POSTCODE: TS1 1QP approach remains very valuable it misses out the patient, or the different proteins may be some important information.

Proteins do not the cause of the disease, in which case they WEB: www.middlesbrough.gov.uk A local against Authority providing full range ofOf local authority Care Link is from exist in isolation from each other, so although could act as targets which new drugs course muchservices. of this was promised Polly Wright a service that provides 24 hour response to passive and proactive assistive studying pureCONTACT: proteins removes interference can be developed. the earliest days of proteomics, and it has technology to help maintain or enhance the quality of life of people with health

JOB ROLE: Service Development Officer from other proteins it alsoTelecare reduces a lot of the be confidence said the results far have not or care needs and their carers - giving to them andso supporting theirlived health and well being. complexity and interaction which is actually a up to expectations. This is in part because key part of how EMAIL: proteins polly.wright@middlesbrough.gov.uk work. the technology has had to catch up with the theory. Some of the equipment used for TEL: 01642 728823 Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Neecom Ltd ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims provide Centre a means amount of computing power required to ThetoQuadrus

ADDRESS: Woodstock Way to map out all the proteins in any given cell or handle the immensely large and complex data Boldon organism, at a given time.

Once you can do generated by this research has also increased Tyne and Wear this it enables you to truly understand how the exponentially over the decade, and finally, but POSTCODE: NE35 9PF chemical building blocks of life truly interact. perhaps most importantly, the people working CONTACT: Michael Harkus in the field have had to develop and perfect

JOB ROLE: Director Neecom are developing a device for use the care and In a way, the genome is rather like a dictionary newintechniques andsheltered methodshome to allow them market sectors. The device will monitor energy use with an emphasis on changing which contains aEMAIL: list of allmichael@neecom.org.uk the possible words to generate and interpret robust reliable data. behaviour in order to achieve lower running costs.

in a language, whereas the proteome is more TEL: 0191 5197258 like the individual books in that language, Since different cell types can be characterised In many ways proteomics has finally caught FAX: 0191 5197259 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

8 6 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Strategic Property Solutions

WEB: www.strategicpropertysolutions. co.uk CONTACT: Steve Cullen

B

ADDRESS: The Stables at the Barn Elm Farm Hobb Lane Daresbury Warrington POSTCODE: WA4 5LS

EMAIL: steve@ strategicpropertysolutionscouk TEL: 01925 740685

C A specialist property development company which brings together the expertise and experience of a number of individuals and organisations to deliver innovative high quality new build and refurbishment health and social care projects.

• Accommodation provider which exclusively provides for vulnerable people in a range of diverse settings • Supply chain partners include specialist health and social care builders and architects and other allied professions

D E F G

Tappa Products Ltd

WEB: www tappa.org.uk

H

ADDRESS: Gear House Saltmeadows Road Gateshead Tyne and Wear POSTCODE: NE8 3AH

CONTACT: Gary Thompson EMAIL: enquiries@tappa.org.uk TEL: 0191 4903335

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: Fabrian Centre Cobalt Business Park The facility will give clients access to expertise Newcastle upon Tyne NE28 9NZfor drug discovery, POSTCODE: in the use of proteomics

development and manufacture and in the WEB: www.trackaphone.com diagnosis and monitoring of disease.

CONTACT: David Leadbitter National Sales Manager The facility JOB ROLE: provides a range of services

includingEMAIL: protein david.leadbitter@trackaphon. extraction, using one of the comhomogenisers in the UK, first pressure cycling protein separation using 2-D Polyacrylamide TEL: 07917 581373 Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein system. Cowley These instruments provide Road arraying ADDRESS: capabilities for biomarker discovery, signal Blyth Riverside Business Park Blyth analysis, protein transduction pathway Northumberland expression analysis, protein identification, POSTCODE: NE24 5TF quantification and characterisation.

WEB: www.tynetec.co.uk

With its main laboratory located on the CONTACT: Anthony Platten Newcastle University and a Managing Director campus JOBof ROLE: Richard Evans CONTACT: second laboratory located on the campus of Manager Durham JOBUniversity, ROLE: Factory NEPAF is supported by the regional development agency One North EMAIL: sales@tynetec.co.uk East and the European Regional Development 01670 352371 TEL:Cels Fund. In 2007 secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

I J TAPPA was developed in response to a genuine need from both Mr and Mrs Kennedy - arthritis sufferers. They needed help operating their bathroom light switch. In response, Alan, a retired Shipyard worker, developed the prototype of what was to become TAPPA.

K

TAPPA provides an aid in operating any standard pull cord, not only light switches

L

but Cels, also emergency and electric showers Through NEPAF hasalarms a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

M

Dr Glen Kemp , project manager, TrackaPhone Ltd NEPAF says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development using TrackaPhone’s proteomics that will secure the is the provision of location based applications for primary business mobile provide reputation of devices. the NorthWe East as thenetwork, place tolocation technology, bearer and device agnostic solutions managed through a fully integrated hosted service allowing do biotech business.” customers to locate and collect a variety of data from the field and view the Achiminformation Treumann,inscientific of interface. real timemanager on a single NEPAF says: “Our aim at NEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic andTynetec commercial research. The level of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com Tynetec has 30 years experience in the design and manufacture of Access Control Systems and Warden Call Systems. Our focus is on the supply and maintenance of telecare/social alarm equipment that can support and enhance the opportunity for people to continue to live in their own home and/or maintain an independent lifestyle with the appropriate level of carer support

N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 8 7

SJB Associates

Helping you to broaden your horizons

Your one-stop Dementia Shop NEW CATALOGUE NOW AVAILABLE l Reminiscence

/ Memorabilia l Snoezelen / Sensory Equipment l Wallpaper / Pre-pasted Murals l Sensory Garden Equipment l Dementia Signage l Memory Boxes l Life story Books l Tactile boards l Crockery & Cutlery

l Menu

Boards & Placemats l Doll Therapy l Rummage Boxes l Aromatherapy l Door Furniture l Toilet seats & Grab Rails l Choices Cards

Please contact us at: 0808 168 5224 Tel: 01325 464562 Mobile: 07849 770349 Email: info@sjbassociates.org.uk Website: www.sjbassociates.org.uk

One stop dementia shop In January 2008, SJB Associates Dementia Design Consultants was launched.

Samantha Brittle the proprietor felt that having had a background in care since childhood that the time and circumstances were right to branch out on her own.

Whilst aware she needed to make a living, she wanted to make a difference too for people living and working with dementia.

Being aware of the need to adhere to budgets, she also wanted to ensure she did not charge exorbitant prices. She works closely with home managers to design and develop areas within their home to make them more esthetically beneficial for people with dementia.

In less than two years SJB Associates, can now boast that they have supplied all the major corporate companies along with a great number of smaller groups and individual owners.

When she formed the company she concentrated on pictorial and Way Finding directional signage and tactile boards, but over the past two years has expanded the company to incorporate around 275 products, working in conjunction with, not in opposition, to many other suppliers

8 8 C E L S H E A LT H C O N N E C T

of products for people with Dementia.

Her aim is to provide a One Stop Shop for Dementia Design Products freeing up valuable time for owners and managers.

in finding specific items for their home now just pick up the phone and ring her explain what they want and leave it to her to research and get back to them.

A new catalogue was launched during the summer, but, already she is working on two supplements to go with the catalogue.

The main focus of her expansion has been market lead and customers focused.

Many customers who have had difficulties

SJB Associates have recently added a fitting service to their portfolio to complete the design process.

For more information contact Samantha by email on info@sjbassociates.org.uk

I would like to thank you for the amazing products your company supplied us with, they have completley transformed our EMI unit here at Ashbourne Lodge. We have had some fantastic compliments from relatives and from our own staff on how lovely the unit looks now. The family tree now holds pride of place and has all our residents photographs on it, its a real talking point!!!. I am sure our CSCI inspector is going to be very impressed with the unit. We are so pleased with the products we will be using them in all of our homes Thanks again Catherine Boult, Area Manager for Winnie Care Homes

be well, connected

Driving the business of life sciences

BIOTECHNOLOGY & LIFE SCIENCES

A B

P R O T E O M I C S FAlcyomics U T ULtdR E OF BIOTECHNOLOGY

C

WEB: www.alcyomics.com

D E

ADDRESS: Bulman House Regent Centre Gosforth Newcastle upon Tyne POSTCODE: NE3 3LS

F

Alcyomics is the UK biologicals and cellular therapeutics service company offering Skin Explant Assay for discovery of therapeutics. Alcyomics assay benefits the pre-clinical stage of drug discovery, speeding development times, lowering costs and minimising risk by evaluating drug candidates (including stem cells) using criteria similar to those in the clinic.

CONTACT: Dr Ian Scoular JOB ROLE: Chief Executive officer EMAIL: ian.scoular@alycomics.com TEL: 07736 226999

G Applied Imaging International Ltd

H I

J

WEB: www.genetix.com

K

L M N O P Q R S T U V W X Y Z

ADDRESS: Unit 7 Queens Park Ground Floor North Wing Queensway North Team Valley Trading Estate Gateshead POSTCODE: NE11 0QD

CONTACT: Simon Smith JOB ROLE: Director of Commercial Operations EMAIL: sales@genetix.com

The term Proteomics was only coined TEL: 0191 4977020 around 14 years ago, it a relatively 0191 4820592 FAX: making new science. It was developed to address a key limitation in classical protein biochemistry.

Genetix’ proven and continuing innovative ability has enabled us to develop a family of systems delivering step changes in the identification and isolation of, for example, therapeutic protein producing cells. Through the acquisition of Applied Imaging Corporation, Genetix now offers the latest technologies for cell screening and selection, genetic testing and cancer pathology, protein science, microarraying, cell and liquid dispensing and a host of related reagents and consumables.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in aAvecia fit healthy Biologics cell from those Ltd in a diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: PO Box 2 a small number of proteins are separated out be a symptom of the disease, in which case Belasis Avenue from all other proteins in Billingham the cell or organism they could help diagnose the disease much Cleveland and studied in great detail.

Although this earlier, and thus improve the prognosis for POSTCODE: TS3 1YN approach remains very valuable it misses out the patient, or the different proteins may be some important information.

Proteins do not the cause of the disease, in which case they WEB: www.avecia.com A leader in the process development and manufacture ofthis microbial-derived exist in isolation from each other, so although could act as targets against which new drugs Of course much of was promised from Bridget Hall biologics. Meeting the challenge of reducing development timelines and coststudying pureCONTACT: proteins removes interference can be developed. the earliest days of proteomics, and it has of-goods. Proprietary expression systems include pAVEway advanced protein

JOB ROLE: Communications Manager from other proteins it also reduces a lot of the said thelargest resultsFDA so and far have not lived expression technology. Avecia has onetoofbe Europe’s MHRA inspected contract facilities for microbial offeringThis flexible EMAIL: biotech@avecia.com complexity and interaction which is actually a up biologics, to expectations. is incapacity part because from 100L - 5000L for all stages of the product pipeline. has had to catch up with key part of how proteins work. the technology TEL: 01642 363511 the theory.

Some of the equipment used for FAX: 01642 364463 Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Bioinnovel Ltd ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Inex Business Incubator to map out all the proteins in any given cell or handle the immensely large and complex data HERSCHEL Annex Newcastle organism, at a given time.

Once youUniversity can do generated by this research has also increased upon Tyne this it enables you to trulyNewcastle understand how the exponentially over the decade, and finally, but POSTCODE: NE1 7RU chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect CONTACT: Joanna Vlahopoulou Bioinnovel provide innovative sensing technology which can increase Founder/CTO

ROLE:is rather In a way, theJOB genome like a dictionary new techniques andindustry methods to allow them productivity and reduce costs in the fast-growing biotech by measuring the mechanical properties of bio-cultures.

Our proven, hardware which contains aEMAIL: list of alljoanna.vlahop@bioinnovel.com the possible words to generate and “intelligent” interpret robust reliable data. and software allow you to accurately monitor and control a range of in a language, whereas the proteome is more

biotechnology processes. The system can be customised to your requirements 0191 TEL: in like the individual books that2430876 language, Since differenttocell types can be characterised many ways has achieve finally caught facilitate efficiencies in terms of timeInand cost.

Ourproteomics customers can FAX: 0191 2223528 effective process control and optimisation for new these do not contain all the words, only those by their own unique proteome fingerprint, up with itself,bio-active that is notcompounds to say therewhich are no arebe currently a lot more than they should to develop & commercialise. needed to tell the story, and the way in which proteomics can used tocosting study how more challenges to overcome, but we are Using our technology, bio-manufacturers will be now able to achieve consistent those words interact dictates how the story embryonic stem cells canand develop any now a better production, avoidinto high failure rates andinlow yields.position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

9 0 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

BioToolomics Ltd

B

ADDRESS: Unit 2-3 Consett Innovation Centre Ponds Court Busininess Park Consett County Durham POSTCODE: DH8 5XP

C

WEB: www.biotoolomics.com

BioToolomics Ltd is a life science company specialised in the innovative process chromatography technology and products for the life science and bioprocessing industries, focused on the theme of “ready-to-use, disposable and high performance”. The major products include IMAC resins, ion-exchange resins, chemical-ligand resins, pre-packed chromatography columns, empty disposable columns etc. We provide customised column packing, resin fabrication and process development services as well.

CONTACT: Chad Zhang JOB ROLE: Director EMAIL: info@biotoolomics.com TEL: 01207 585820 FAX: 01207 585852

D E F G

BioTransformations Ltd (BTL)

WEB: www.biotransformations.com

H

ADDRESS: Cels at Newcastle William Leech Building Framilington Place Newcastle upon Tyne Tyne and Wear POSTCODE: NE2 4HH

CONTACT: Colin Self JOB ROLE: CSO EMAIL: colinself@biotransformations.com

NEPAF (the North East Proteome Analysis TEL: 0191 2235601

I J The commercial focus of BioTransformations Ltd (BTL) is aimed at greatly improving the specificity, safety and efficiency of anti-cancer treatment using monoclonal antibodies (Mabs).

BioTransformations technology is capable of controlling the activity of antibodies and other protein based active agents in the body. This approach increases efficiency and specificity of antibody based therapeutics and can be readily Through Cels, NEPAF has a dedicated applied to existing monoclonal antibodies.

Facility) will work with a wide range of research team of six scientists, including experienced and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and will provide Dr GlenResearch Kemp , projectBiochemicals manager, NEPAF Cambridge Ltd them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art

ADDRESS: 10 Belasis Court facilities that allow even the smallest of Belasis Hall The facility will give clients access to expertise companies to carry out the research they Technology Park Billingham in the use of proteomics for drug discovery, need. NEPAF’s goal is to support companies development andCleveland manufacture and in the carrying out significant and, in some cases, POSTCODE: TS23 4AZ diagnosis and monitoring of disease. ground-breaking research and development usingAt proteomics that will secure the Cambridge Research Biochemicals we work very closely with our customers to WEB: www.crbdiscovery.com provide the North very best The facility provides a range of services reputation of the Eastcustom as the peptide place toand antibody service. We are proud of the fact that we have been working with the same top pharmaceutical companies CONTACT: Emily Humphrys protein Sales extraction, using one of the do biotech business.”

Director and key research professionals within these accounts for over fifteen years. including JOB ROLE: first pressure cycling homogenisers in the UK, Achim Treumann, scientific manager of EMAIL: brbsales@crbdiscovery.com protein separation using 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use

Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions TEL: 01642 567180 multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six CBSL academic commercial research. The level (Cels and Business Services Ltd) different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable

ADDRESS: Quorum 16 capabilities for biomarker discovery, signal results and our scientists’ communication Quorum Business Park transduction pathway analysis, skills ensure that you will understand them. ” Benton Lane protein Newcastle Tyne expression analysis, protein upon identification, POSTCODE: NE12 8BX quantification and characterisation.

For further information visit: www.nepaf.com WEB: www.cbsl-uk.com CBSL provides consultancy services to support start-up and existing companies, With its main laboratory located on the universities and public sector clients across the UK. Specialists in healthcare Mike Nicholds CONTACT: campus of Newcastle University and a and life sciences, CBSL has an excellent track record of delivering consultancy

JOB ROLE: Managing Director services to clients in the private and public sector based on the wealth of second laboratory located on the campus of expertise in the commercialisation of life science and healthcare technology. enquiries@cbsl-uk.com Durham EMAIL: University, NEPAF is supported by With a strong team of consultants focussing on the North East of England and

the regional development agency One North Scotland, CBSL draws on over 100 years’ collective experience of working across TEL: 0191 215 5025 sectors including industry, academia and the NHS in areas of innovation and East and the European Regional 0191 215 5125 Development FAX: commercialisation, project evaluation, economic development, research and Fund. In 2007 Cels secured £4 million to technology transfer. develop the facility, which is the only one of its kind in the North East of England.

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 9 1

A B

P R O T E O M I C SComplement F U TGenomics U R ELtd OF BIOTECHNOLOGY

C D

ADDRESS: 128 Bioscience Centre Business & Innovation Centre Wearfield Sunderland Tyne and Wear POSTCODE: SR5 2TA WEB: www.geneblitz.com www.dadcheck.com

E

F

Complement Genomics Ltd operates a molecular biology service division (Geneblitz) which provides DNA sequencing, genotyping, human and animal identification, forensic testing, Q-PCR/biomarker analysis, Ames testing and a range of other services, B2B.

CONTACT: Louise Allcroft JOB ROLE: Chief Executive EMAIL: louise.allcroft@compgene.com TEL: 0191 5166500

Also a leader in paternity and human relationship testing via its accredited dadcheck service, where it services both the general public and legal profession with a high standard of customer care.

G Cord8 Ltd

H I

J

WEB: www.cord8.com

K

L M N O P Q R S T U V W X Y Z

ADDRESS: Unit 124i The Business and Innovation Centre Wearfield Sunderland Tyne and Wear POSTCODE: SR5 2TA

CONTACT: Dr Neil Sullivan JOB ROLE: CEO

Cord8 Ltd stores genetic material. We archive, catalogue and store nucliec acids for the biotechnology, healthcare and pharmaceutical sectors and also offer DNA storage to the general public.

TEL: 07906 667354

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteins in a fit healthy cell Technology from those in a Creative Gene Ltd What is more, since proteomics can diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural

ADDRESS: Technology Transfer Office a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food & NECSE from all other proteins in Durham the cell or organism they could help diagnose the disease much crops and more efficient biofuels, and in University Mountjoy Research Centre earlier, and thus improve the prognosis for and studied in great detail.

Although this microbiology to both fight microbes and to Durham approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity.

POSTCODE: DH1 3UP some important information. Proteins do not the cause of the disease, in which case they Keith Lindsey Creative Gene which Technology Ltd is using Of thecourse powerful technologies proteomics, CONTACT: exist in isolation from each other, so although could act as targets against new drugs much of this wasofpromised from DNA microarray and genetics to develop new solutions for increasing crop studying pure proteins removes interference can be developed. the earliest days of proteomics, and it has yield and productivity for agriculture. The world population is growing, but the EMAIL: keith.lindsey@durham.ac.uk from other proteins it also reduces a lot of the to be the that results so far have lived available land for crop production is not.

Thissaid means improving cropnot yield will

3341309 become an increasingly pressing objective.

TEL: 0191 complexity and interaction which is actually a up to expectations. This is in part because key part of how proteins work. the technology has had to catch up with the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Demuris Ltd ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to at provide a means amount of computing power required to Cels Newcastle

ADDRESS: First to map out all the proteins inFloor any given cell or handle the immensely large and complex data William Building organism, at a given time.

OnceLeech you can do generated by this research has also increased Faculty of Medical Sciences this it enables you to trulyFramlington understandPlace how the exponentially over the decade, and finally, but chemical building blocksNewcastle of life truly upon interact. perhaps most importantly, the people working Tyne POSTCODE: NE2 4HH in the field have had to develop and perfect Demuris is a biotechnology company specialising in theand discovery of novel In a way, the genome is rather like a dictionary new techniques methods to allow them WEB: www.demuris.co.uk antibacterial agents. A spin out from Newcastle University, Demuris takes exciting which contains a list of all the possible words to generate and interpret robust reliable data. new ideas for antibiotic drug screening, and initiates discovery programmes Claire Miller is more CONTACT: in a language, whereas the proteome aiming to develop candidate drugs for partnering with pharmaceutical and

JOB ROLE: Administration manager like the individual books in that language, Since differentbiotechnology cell types cancompanies. be characterised In many ways proteomics has finally caught these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no EMAIL: claire.miller@demuiris.co.uk to tell the story, and the way in which needed proteomics can be used to study how more challenges to overcome, but we are TEL: 0191 2235608 those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to FAX: 0191 2235609 is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

9 2 C E L S H E A LT H C O N N E C T

changing as it ages and even in response to changes from outside and within.

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Epigem Ltd

B

ADDRESS: Malmo Court Kirkleatham Business Park Redcar Cleveland POSTCODE: TS10 5SQ

C

WEB: www.epigem.co.uk

CONTACT: Tim Ryan JOB ROLE: Managing Director EMAIL: info@epigem.co.uk TEL: 01642 496300 FAX: 01642 496301

Epigem manufactures instrumentation disposables and modules for drug discovery and medical research. Our product development services support healthcare applications ranging from diagnostic bio-analysis to biological cell processing . Epigem is a pace setter in the field of polymer micro and nano technology (MNT); partnering companies in the electronics, chemicals and life science industries.

D E F G

e-Therapeutics plc

WEB: www.etherapeutics.co.uk

H

ADDRESS: Holland Park Holland Drive Newcastle upon Tyne Tyne and Wear POSTCODE: NE2 4LZ

CONTACT: Professor Malcolm Young JOB ROLE: Chief Executive EMAIL: malcolm@etherapeutics.co.uk

NEPAF (the TEL: North0191 East2331317 Proteome Analysis FAX: 0191 2331303 Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: Cels At Newcastle Medical School The facility will give clients of access to expertise University Newcastle Newcastle Tyne in the use of proteomics for upon drug discovery, and Wearand in the development andTyne manufacture POSTCODE: NE2 4HH

diagnosis and monitoring of disease.

WEB: www.genesisgenomics.co.uk

The facility provides a range of services CONTACT: Andrew Harbottle PhD including protein extraction, using one of the first pressure cycling homogenisers in the UK, andrew.harbottle@ EMAIL: genesisgenomics.co.uk protein separation using 2-D Polyacrylamide Gel Electrophoresis (2D-PAGE) and TEL: 0191 2211535 multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide

ADDRESS: INEX Business Centre capabilities for biomarker discovery, signal Herschel Annex transduction pathway analysis, proteinCampus Newcastle University Newcastle Tyne expression analysis, protein upon identification, POSTCODE: NE1 7RU quantification and characterisation.

WEB: www.geneiuslabs.co.uk

With its main laboratory located on the Jerry Barnes CONTACT: campus of Newcastle University and a

JOB ROLE: Managing Director second laboratory located on the campus of info@geneiuslabs.com Durham EMAIL: University, NEPAF is supported by the regional development agency One North TEL: 0191 2430874 East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

I J As a systems biology drug discovery company, e-Therapeutics possess efficient proprietary methods for discovering new bioactive compounds; de-risking candidates against efficacy and safety; discovering combinations of compounds with specific therapeutic effects; and discovering surprising new indications for existing compounds. The company pioneered network based discovery and has two products in Phase 3 and a further 6 clinical stage drug candidates

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

K L M

DrGenesis Glen Kemp ,Genomics project manager, NEPAF Ltd says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development usingGenesis proteomics that will secure the a comprehensive suite of scientifically proven Genomics plans to offer skin wellness products services sunscreens, anti-oxidants, DNAreputation of the North Eastand as the placeincluding to based sun damage testing and monitoring, followed by personalised healthy sun do biotech lifestylebusiness.” programs. As well as ultimately, a clinical diagnostic test to detect skin Achimcancer Treumann, scientific manager of the appearance of clinical symptoms, when at very early stages, before thesays: opportunity foratintervention NEPAF “Our aim NEPAF is toand usesuccessful treatment is at its greatest. leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic andLaboratories commercial research.

The level Geneius Ltd of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com Geneius offers a revolutionary food analysis service using state-of-the-art DNA technology. The company’s approaches sets it apart from its competitors, and enables the delivery of unprecedented turnaround times and accuracy in the detection and confirmation of targeted microbial contaminants - welcome news for any food and drink manufacturer/supplier wishing to quickly and reliably ensure positive product release.

N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 9 3

A B

P R O T E O M I C S FGlaxoSmithKline UTURE OF BIOTECHNOLOGY

C

ADDRESS: Harmire Road Barnard Castle County Durham POSTCODE: DL12 8DT WEB: www.gsk.co.uk

D

CONTACT: Roger Conner EMAIL: ukbusinessdevelopment@gsk.com

E

TEL: 01833 690600

F

GlaxoSmithKline, one of the world’s leading research-based pharmaceutical and healthcare companies, is committed to improving the quality of human life by enabling people to do more, feel better and live longer. We are one of the few pharmaceutical companies researching both medicines and vaccines for the World Health Organisation’s three priority diseases – HIV/AIDS, tuberculosis and malaria, and are very proud to have developed some of the leading global medicines in these fields. Headquartered in the UK and with operations based in the US, we are one of the industry leaders, with an estimated seven per cent of the world’s pharmaceutical market.

G Helena Biosciences Europe

H I J K L M N O P Q R S T U V W X Y Z

ADDRESS: Queensway South Team Valley Trading Estate Gateshead Tyne and Wear POSTCODE: NE11 0SD WEB: www.helena-biosciences.com EMAIL: info@helena-biosciences.com TEL: 0191 482 8440

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

Helena Biosciences Europe designs, manufactures and markets the most innovative diagnostic systems and biomedical technology for the progress of healthcare and medical science.

Our business is unique because we provide a diverse spectrum of highly specialised in-vitro medical instrumentation, biotechnology and equipment, serving scientists, doctors and practitioners in research institutes, hospitals and changing as itlaboratories. ages and even in response to to give us important insights in the ageing

changes from outside and within.

process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in aForce fit healthy cell from those in a(HFR) High Research Ltd diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: Bowburn North Industrial Estate a small number of proteins are separated out be a symptom of the disease, in which case Bowburn from all other proteins in Durham the cell or organism they could help diagnose the disease much DH6 5PF and studiedPOSTCODE: in great detail.

Although this earlier, and thus improve the prognosis for approach remains very valuable it misses out the patient, or the different proteins may be WEB: www.highforceresearch.com some important information. Proteins do not the cause of the disease, in which case they Bob Redfern High Force Research (HFR) offers confidential, high quality for CONTACT: exist in isolation from each other, so although could act as targets against whichLtd new drugs Of course much of this services was promised from Managing Director outsourced synthesis and R&D from the scale of grams to kilos. With wide pureJOB ROLE: removes studying proteins interference can be developed. the earliest days of proteomics, and it has experience of multistep organic synthesis, particularly of heterocyclic chemistry, from other proteins it alsoenquires@highforceresearch.com reduces a lot of the to be saidacid the results so far have not and lived catalytic hydrogenation, nucleoside and amino chemistry, fluorination EMAIL: chiral chemistry. We produce API’s to cGMP standards for preclinical studies and

complexity and interaction which is actually a up to expectations.

This is in part because phase I trials in MHRA audited clean room TEL: 0191 key part of how proteins work.3779098 the facilities technology has had to catch up with FAX: 0191 3779099 the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic Kromek t/a Durham Scientific Crystals to discover Ltd more proteins, more accurately ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: NetPark Incubator to map out all the proteins in anyWright given cell handle the immensely large and complex data Thomas Wayor Sedgefield organism, at a given time.

Once you can do generated by this research has also increased Durham this it enables you to trulyCounty understand how the exponentially over the decade, and finally, but POSTCODE: TS21 3FD chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect WEB: www.kromek.com Kromek is pioneering digital colour imaging for x-rays and has broughtto groundIn a way, the genome is rather like a dictionary new techniques and methods allow them breaking innovation to materials technology and advanced 3D imaging, that will CONTACT: Natalie Heslop which contains a list of all the possible words to generate and interpret robust reliable data. literally change the way in which we see the world.

JOB ROLE: PA to CEO in a language, whereas the proteome is more natalie.heslop@kromek.com specialises making semiconductor materials within the Cadmium like the individualEMAIL: books in that language, Since differentKromek cell types can be in characterised In many ways proteomics has finally caught Telluride family. These materials have significant applications as detectors of these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no x-rays and gamma rays, notably in medical imaging, security screening, industrial TEL: 01740 625255 needed to tell the story, the625257 way in which proteomics can be usedand to study morefor challenges to overcome, butof we are 01740 inspection spacehow exploration, allowing very precise identification FAX: and materials those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

9 4 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Millipore UK Ltd

B

ADDRESS: Unit 31 No1 Industrial Estate Consett County Durham POSTCODE: DH8 6SZ

C

WEB: www.millipore.com

Millipore is a life science leader providing cutting-edge technologies, tools and services for bioscience research and biopharmaceutical manufacturing. Since its founding in 1954, Millipore has expanded its capabilities through strategic acquisitions, targeted capital investments, and organic growth.

TEL: 01207 581555 FAX: 01207 500944

Today we offer an extensive portfolio of products and services in: Life Sciences, Drug Discovery and Development, Lab Filtration, Lab Water, Upstream Bioprocessing, Downstream Bioprocessing and Process Monitoring.

D E F G

Merck Sharp & Dohme Ltd (MSD)

H

ADDRESS: Shotton Lane Cramlington Northumberland POSTCODE: NE23 3JU

I J

WEB: www.msd-uk.co.uk

EMAIL: externalaffairs_uk@merk.com TEL: 01670 593000 FAX: 01670 593001

Merck Sharp & Dohme Limited (MSD) is the UK subsidiary of Merck & Co., Inc., of Whitehouse Station, New Jersey, USA, a leading research-based pharmaceutical company that discovers, develops, manufactures and markets a wide range of innovative pharmaceutical products to improve human health.

NEPAF (the North East Proteome Analysis Through Cels, NEPAF has a dedicated Facility) will work with a wide range of research team of six scientists, including experienced and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and will provide Dr Glen Kemp , project manager, NEPAF And Health Newcastle University Institute For Ageing them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art

ADDRESS: Newcastle University facilities that allow even the smallest of Campus for Ageing and Vitality The facility will give clients access to expertise companies to carry out the research they Newcastle upon Tyne Tyne andfor Wear in the use of proteomics drug discovery, need. NEPAF’s goal is to support companies 5PL POSTCODE: development andNE4 manufacture and in the carrying out significant and, in some cases, diagnosis WEB: and monitoring of disease. ground-breaking research and development www.ncl.ac.uk/iah usingThe proteomics that will secure the is now amongst the world’s leading research Institute for Ageing and Health Graham Armitage organisations in its East field. as It brings together CONTACT: The facility provides a range of services reputation of the North the place to over 250 researchers from many fields to investigate and advise on healthy ageing, age related conditions and the needs

JOB ROLE: Programme Director including protein extraction, using one of the do biotech business.” of an ageing society. and opportunities first pressure cycling homogenisers in the UK, Achim Treumann, scientific manager of graham.armitage@ncl.ac.uk EMAIL: protein separation using 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use TEL: 0191 2481301 Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and NEPAF commercial research. The level different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable

ADDRESS: Devonshire Building capabilities for biomarker discovery, signal results and our scientists’ communication Devonshire Terrace transduction pathway analysis, protein skills ensure that you will understand them. ” Newcastle upon Tyne NE1 protein 7RU POSTCODE: expression analysis, identification, quantification and characterisation.

For further information visit: WEB: www.nepaf.com www.nepaf.com Glen Kemp Proteomics expertise to accelerate life science research and development.

With CONTACT: its main laboratory located on the Programme Manager

JOBof ROLE: campus Newcastle University and a NEPAF (the North East Proteome Analysis Facility) works with a wide range of second laboratory located on the campus of research and development groups and healthcare companies in the private EMAIL: glen.kemp@celsgroup.com and public sector in the UK and internationally, providing them with access to

Durham University, NEPAF is supported by 0191 2223679 leading expertise and equipment for the study of proteins. the regionalTEL: development agency One North FAX: 0191 2155125 East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 9 5

A B

P R O T E O M I C S FNorthGene U T ULtdR E OF BIOTECHNOLOGY

C

ADDRESS: Institute of Human Genetics Central Parkway Newcastle upon Tyne POSTCODE: NE1 3BZ EMAIL: info@paternitytesting.co.uk

D

NorthGene is one of the UK’s leading relationship testing companies and the only one that donates any profits to medical research and education.

TEL: 0844 8006951 FAX: 0191 2418680

At NorthGene we pride ourselves on offering a friendly, efficient and fully confidential service and we are dedicated to supporting our clients through what we understand can be a very difficult process.

E F G

Nzomics Biocatalysis

H I

J

WEB: www.nzomics.com

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: 21/22 Ellison Place Newcastle upon Tyne Tyne and Wear POSTCODE: NE1 8ST

CONTACT: Graham Hopson JOB ROLE: Conmmercialisation Manager EMAIL: graham.hopson@northumbria. ac.uk TEL: 0191 2437590

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

Nzomics Biocatalysis offers products, services and expertise to those companies looking to use biocatalysis in a post-genomic era. This presents opportunities for R&D teams to exploit state of the art advances in enzyme production and optimization.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a Onyx fit healthyScientific cell from thoseLtd in a diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just Silverbriar ADDRESS: a small number of proteins are separated out be a symptom of the disease, in which case Enterprise Park East from all other proteins in Sunderland the cell or organism they could help diagnose the disease much Tyne and Wear and studiedPOSTCODE: in great detail.

Although this earlier, and thus improve the prognosis for SR5 2TQ approach remains very valuable it misses out the patient, or the different proteins may be WEB: www.onyx-scientific.com some important information.

Proteins do not the cause of the disease, in which case they Onyx Scientific a wide services to the sciencesfrom exist in isolation from each other, so although could act as targets against provides which new drugsrange of Ofchemical course much of this waslife promised CONTACT: Tony Flinn industry. Specialising in medicinal chemistry, pre-clinical development and GMP studying pure proteins removes interference can be developed. the earliest days of proteomics, and it has

JOB ROLE: Chief Executive Officer scale-up, in addition they offer a comprehensive range of analytical services. from other proteins it also reduces a lot of the to be said the results so far have not lived EMAIL: tonyflinn@onyx-scientific.com One of the fastest growing pharmaceutical companies UK, because Onyx complexity and interaction which is actually a up to service expectations.

This in is the in part

Scientific has more than 40 expert scientists specialisinghas in drug key part of how proteins work.5166516 the technology had development to catch up with TEL: 0191 FAX: 0191 5166526 the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic Orla Protein Technologies Ltd to discover more proteins, more accurately ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to Bioscience Centre

ADDRESS: International Centre to map out all the proteins in any given cell orfor Life handle the immensely large and complex data Times Square organism, at a given time.

Once you can do generated by this research has also increased Newcastle upon Tyne this it enables you to truly understand how the exponentially over the decade, and finally, but POSTCODE: NE1 4EP chemical building blocks of life truly interact. perhaps most importantly, the people working WEB: www.orlaproteins.com in the field have had to develop and perfect Orla Protein Technologies has developed, and commercialized a them In a way, theCONTACT: genome is rather like a dictionary newpatented, techniques and methods to allow Dale Athey technology that radically simplifies the way in which proteins are immobilized which contains a ROLE: list of allCEO the possible words to generate and interpret robust reliable data.

JOB on surfaces. This leads to dramatic improvements in functionality, utility, and in a language, whereas the proteome is more manufacture. In 2009 Orla has formed a an new joint venture company with EMAIL: dale.athey@orlaproteins.com Radiocan Cobe Ltd. OJ-Bio will develop a range of revolutionary like the individual books in that language, Since differentJapan cell types characterised In and manysellways proteomics has finally caught

wireless diagnostic devices. these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no TEL: 0191 2313127 needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

9 6 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Piramal Healthcare UK Ltd

B

ADDRESS: Whalton Road Morpeth Northumberland POSTCODE: NE61 3YA

C

WEB: www.piramalhealthcare.com

CONTACT: Aidan Walker JOB ROLE: Site Manager EMAIL: aidan.walker@piramal.com TEL: 01670 562400 FAX: 01670 562682

Piramal Healthcare offers a comprehensive range of services to the pharmaceutical industry, supporting pre-clinical and early clinical development of new pharmaceutical products as well as commercial supply. Piramal Healthcare can provide advanced intermediates and active pharmaceuticals, at laboratory, kilogram, pilot plant scale and commercial quantities and can also manufacture formulations batches for clinical studies.

D E F G

Procter & Gamble

WEB: www.uk.pg.com CONTACT: Mike Addison

H

ADDRESS: Newcastle Technical Centre Whitley Road Longbenton Newcastle upon Tyne Tyne and Wear POSTCODE: NE12 9TS

I J Procter & Gamble is one of the world’s biggest fast moving consumer goods companies in the world with a long track record of bringing innovation to the markets in which we compete. To learn more of our company and interests please visit www.pg.com.

EMAIL: addison.mc@pg.com 1074 Analysis NEPAF (the TEL: North0191 East228 Proteome Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: Hobson Industrial Estate Burnopfield Newcastle upon Tyne The facility will give clients access to expertise Tyne andfor Wear in the use of proteomics drug discovery, POSTCODE: NE16 6EA

development and manufacture and in the www.quantum-specials.co.uk diagnosis WEB: and monitoring of disease.

CONTACT: Ian Edge provides a rangeDirector of services Managing The facility JOB ROLE:

including protein extraction, using one of the helen_tinker@quantum-specials.

EMAIL: first pressure cycling homogenisers in the UK, co.uk

protein separation using 2-D Polyacrylamide TEL: Gel Electrophoresis (2D-PAGE) 279 404 and FAX: 01207 multi-dimensional01207 liquid279372 chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein system. School These instruments of Biological provide and arraying ADDRESS: capabilities for biomarker discovery, Biomedical Science signal Durham University transduction pathway analysis, protein South Road expression analysis, protein identification, Durham quantification characterisation.

DH1 3LE POSTCODE:and WEB: www.reinnervate.com With its main laboratory located on the campus of Newcastle StefanUniversity Przyborskiand a CONTACT: Chief second JOBlaboratory ROLE: Director located& on theScientific campus Officer of Durham University, NEPAF is supported by EMAIL: stefan.przyborski@reinnervate.com the regional development agency One North 0191 3343988 East and the European Regional Development TEL: 0191 3341201 FAX:Cels Fund. In 2007 secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

K L

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

M

DrQuantum Glen Kemp , project manager, NEPAF Specials Ltd says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development usingDedicated proteomicstothat will secure the providing a comprehensive high quality range of commonly used pharmaceutical reputation of the Northspecials, East as Quantum the place uses to modern pharmaceutical manufacturing processes within an exceptionally high standard clean environment to ensure do biotech business.” patient health and safety. The clean room provides facilities above the standard Achimrequired Treumann, scientific manager for the manufacture of of Specials.

NEPAF says: “Our aim at NEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic and commercial Ltd research. The level ReInnervate of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com ReInnervate specialises in the development of enabling technologies to facilitate research into cell growth and function in vitro with immediate applications to research and development in the academic, healthcare, biotechnology and pharmaceutical sectors. The Company has three primary areas of interest: • Development of more favourable growth conditions for cells in vitro; • Design and synthesis of molecules that control cell differentiation; • Development of new strategies in neural stem cell research.

Aspects of the Company’s research programme also have potential for development into diagnostic tools and have possible therapeutic uses.

N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 9 7

A B

P R O T E O M I C S FSCM UT URE Pharma OF BIOTECHNOLOGY

C D E F

ADDRESS: Unit 6 Regents Drive Low Prudhoe Industrial Estate Northumberland POSTCODE: NE42 6PX WEB: www.scm-pharma.com

SCM Pharma provides a wide range of small-medium scale manufacturing, filling, development and packaging services to meet clinical trial and commercial needs. Working with top 20 pharma, the company operates as a centre for excellence and cater for clients in the pharmaceutical, bio and healthcare sectors. Specialist offerings include sterile and non-sterile manufacturing, aseptic processing, radiopharma, Biologicals, cytotoxics and clinical packaging services.

CONTACT: Raman Sehgal JOB ROLE: Marketing Manager EMAIL: info@scm-pharma.com TEL: 01661 838186

G H I J

Selective Antibodies Ltd

ADDRESS: Cels at Newcastle William Leech Building Framlington Place Newcastle upon Tyne Tyne and Wear POSTCODE: NE2 4HH WEB: www.selectiveantibodies.com

K L M N O P Q R S T U V W X Y Z

CONTACT: Colin Self

Selective Antibodies is a diagnostics company with the prime focus of overcoming key technological problems key to the production of high performance point of need systems for small target molecules such as medicaments, natural and unnatural toxins such as fungal toxins and pesticides and other substances of importance to forensic investigation and the food and water industries.

EMAIL: colinself@selectiveantibodies. com TEL: The term Proteomics coined changing as it ages and even in response to 0191only 2235604/1 FAX: was 01661 820532 around 14 years ago, making it a relatively changes from outside and within.

new science. It was developed to address a key limitation in classical protein biochemistry.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fitSensaPharm healthy cell from those Ltdin a diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: Unit 124i a small number of proteins are separated out be a symptom of the disease, in which case The Business and Innovation Centre from all other proteins in Wearfield the cell or organism they could help diagnose the disease much Sunderland and studied in great detail.

Although this earlier, and thus improve the prognosis for Tyne and Wear approach remains very valuable it misses out the patient, or the different proteins may be POSTCODE: SR5 2TA some important information. Proteins do not the cause of the disease, in which case they www.sensapharm.eu SensaPharm Ltdwhich is involved in biomarker, drug detection using both WEB: exist in isolation from each other, so although could act as targets against new drugs Ofprotein courseand much of this was promised from LCMSMS system and a number of sensor platforms. The company develops and studying pure proteins removes interference can be developed. the earliest days of proteomics, and it has validates assays and detection systems for the above to commercial guidelines.

CONTACT: Neil Sullivan from other proteins it alsoDirector reduces a lot of the to be said the results so far not lived Plus the company has two major product development interests 1. have the detection

JOB ROLE: of the anti malarial drug artemisinin 2. the development of a biomarker complexity and interaction which is actually a up to expectations.

This is in partderived because sensor for wound care applications. the technology has had to catch up with key part of how EMAIL: proteins neil@sensapharm.eu work.

the theory. Some of the equipment used for TEL: 0191 5166969 Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately The Specials Laboratory ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Unit 1 to map out all the proteins in any Drive given cell or handle the immensely large and complex data Regents Low Prudhoe Industrial organism, at a given time.

Once you can do Estate generated by this research has also increased this it enables you to trulyNorthumberland understand how the exponentially over the decade, and finally, but POSTCODE: NE42 6PX chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect WEB: www.specialslab.co.uk The Specials Laboratory manufactures new unlicensed medicines for the retail In a way, the genome is rather like a dictionary techniques and methods to allow them pharmaceutical and healthcare markets. The award-winning company CONTACT: Jan Armstrong which contains a list of all the possible words to generate and interpret robust reliable data. reliably makes and delivers ‘specials’ to thousands of Pharmacists and Doctors in a language, whereas proteome is more jana@specialslab.co.uk throughout the UK - within just 24 hours of an order being placed.

EMAIL: the individual books in that language, like the Since different cell types can be characterised In many ways proteomics has finally caught The company now also supplies hospitals with overlabelled products and are TEL: 01661 839256 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no licensed to offer IMP services. needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

9 8 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

VH Bio Ltd

ADDRESS: Unit 11B Station Approach Team Valley Trading Estate Gateshead Tyne and Wear POSTCODE: NE11 0ZF WEB: www.vhbio.com CONTACT: Sue Smith

A

EMAIL: ssmith@vhbio.com TEL: 0191 495 8214 FAX: 0191 4874285

B C VH Bio provides a range of products for immunologists and molecular biologists.

The Company offers the following product ranges: • Products for organ transplant diagnostics • Automated DNA extraction instruments and kits • DNA sequencing and clean-up products • DNA electrophoresis instruments and pre-prepared gels • Molecular biology reagents • A wide variety of monoclonal antibodies for research purposes • Lymphocyte separation products

CONTACT: geoffrey.toms@ncl.ac.uk

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

The facility will give clients access to expertise in the use of proteomics for drug discovery, development and manufacture and in the diagnosis and monitoring of disease.

The facility provides a range of services including protein extraction, using one of the first pressure cycling homogenisers in the UK, protein separation using 2-D Polyacrylamide Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide capabilities for biomarker discovery, signal transduction pathway analysis, protein expression analysis, protein identification, quantification and characterisation.

With its main laboratory located on the campus of Newcastle University and a second laboratory located on the campus of Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

F

H

ADDRESS: Newcastle University The Medical School Framlington Place Newcastle upon Tyne Tyne and Wear POSTCODE: NE2 4HH WEB: Geoffrey Toms

E

G

Viratom Ltd

D

I Viratom Ltd provides expertise in the culture of fastidious human viral pathogens and systems for the development and evaluation of antiviral drugs and monoclonal antibodies.

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

Dr Glen Kemp , project manager, NEPAF says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development using proteomics that will secure the reputation of the North East as the place to do biotech business.”

Achim Treumann, scientific manager of NEPAF says: “Our aim at NEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic and commercial research. The level of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com

J K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 9 9

T H E N E W C A S T L E H O S P I TA L S - L E A D I N G T H E H E A LT H C A R E ECONOMY

The Newcastle upon Tyne Hospitals NHS Foundation Trust has been providing patient-centred healthcare to communities in the North East of England and beyond for over 250 years. Newcastle Hospitals is one of the largest trusts in the UK, offering a wider range of specialist services than any other. The Care Quality Commission has rated Newcastle Hospitals as “double excellent” for quality of services and use of resources and has also been rated in the Top 40 Hospitals for nine years running by CHKS. The Trust has developed strong partnerships within the commercial healthcare sector, supporting exciting businesses such as NewGene, which provides molecular diagnostics and research services.

NewGene - Next Generation Diagnostics The Trust is working with NewGene to develop new genetic diagnostic tests using the latest technologies. This will reduce test development and laboratory turnaround times which will help the NHS meet the ever increasing demand for genetic diagnostic tests and so improve and enhance services to patients.

One example of NewGene’s activities is its development of a new diagnostic test for patients with metastatic colon cancer. The test helps clinicians to determine the most effective drug therapy for ongoing treatment on the basis of the tumour genotype. The test took only two months to develop and demonstrates NewGene’s ability to bring on stream tests for clinical use within extremely short time frames.

NewGene were the 2009 winners of the prestigious North East Business for Life “Partnership with the NHS” award.

1 0 0 C E L S H E A LT H C O N N E C T

Pulse Diagnostics Limited Pulse Diagnostics Limited is a further example of how Newcastle Hospitals works in partnership with businesses. The Trusts Medical Physics Department based at the Freeman Hospital has developed a noninvasive system for detection of vascular disease. The business was formed as a joint venture to enable the development of a commercial product to promote to the marketplace. Newcastle Hospitals is the lead shareholder in Pulse Diagnostics Limited along with venture capitalists Exomedica and NHS Innovations, RTC North.

Evaluation of Medical Devices The Trust’s Medical Physics Department is one of only twelve centres in the UK that can provide advice on the clinical and costeffectiveness of medical devices for use in the NHS. The Department specialises in evaluating devices used in cardiology, respiratory medicine, intensive care, A&E and audiology.

Businesses throughout the UK can benefit from the Medical Physics team’s vast experience and expertise in various assessment techniques. The NHS Evidence portal www.evidence.nhs.uk provides

evaluation reports, buyers’ guides and market reviews of work in this area..

Supporting the Economic Development of North East England As the two largest employers in Newcastle, the Trust’s partnership with Newcastle University has a vital role to play in the economic development of the region.

The Newcastle Biomedicine partnership is currently developing a combined commercialisation and intellectual property strategy and is establishing a joint vehicle for further development of the Campus for Aging and Vitality at the Newcastle General Hospital. Working closely with Newcastle City Council, One North East, and the University, this partnership continues to play a full role in developing themes supporting the Newcastle Science City initiative i.e. Ageing and Vitality, Genetics, Stem Cells and Regenerative Medicine at the International Centre for Life.

The Newcastle upon Tyne Hospitals NHS Foundation Trust is committed to delivering healthcare at its very best and working in collaboration with CELS and other partners in business and supporting academics to achieve excellence in the business of health in North East England.

be well, connected

Driving the business of life sciences

NHS & CLINICAL

A B

P R O T E O MCityI C S Sunderland FUTU RFoundation E Trust Hospitals NHS OF BIOTECHNOLOGY

C

ADDRESS: Sunderland Royal Hospital Kayll Road Sunderland POSTCODE: SR4 7TP

City Hospitals Sunderland NHS Foundation Trust provides a wide range of hospital services to our local community along with an increasing range of more specialised services to patients outside this area. Whilst the main focus of our services is acute, the Trust also provides a substantial range of community-based services. The Trust operates from: • Sunderland Royal Hospital (owned by the Trust) • Sunderland Eye Infirmary (owned by the Trust) • Ryhope General Hospital (on a limited basis) • Monkwearmouth Hospital (on a limited basis)

WEB: www.sunderland.nhs.uk/chs

D

CONTACT: Ken Bremner JOB ROLE: Chief Executive

E

TEL: 0191 5656256

It also provides some outreach services at Washington Galleries, University Hospital of North Durham, Shotley Bridge Hospital, Hartlepool General Hospital and the South Tyneside General Hospital.

F G

Clinical Ageing Research Unit (CARU)

H I J K L M N O P Q R S T U V W X Y Z

ADDRESS: Clinical Ageing Research Unit Campus for Ageing and Vitality Newcastle University POSTCODE: NE4 5PL WEBSITE: www.ncl.ac.uk/caru/ CONTACT: Professor David Burn EMAIL: d.j.burn@ncl.ac.uk TEL: 0191 2481250 FAX: 0191 2481251

The primary aim of CARU is to facilitate the development of early assessment and intervention strategies targeted at age-associated degenerative conditions.

The facility will also provide an ideal high-quality patient-friendly environment for phase II-IV clinical studies in the older patient.

Commitment to research in this area is strengthened by the presence of the UK Dementia and

The term Proteomics was only coined changing as itNeurodegenerative ages and even in response to to give us important insights in the ageing Disease Network (DeNDRoN) local around 14 years ago, making it a relatively changes fromresearch outside network. and within. process as a whole. So there are scientific new science. It was developed to address questions proteomics can help us answer, a key limitation in classical protein For example if you could compare the literally from cradle to grave. biochemistry. proteins in aand fit healthy cell from those in a Foundation What is more, since proteomics can County Durham Darlington NHS Trust diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural County Durham and Darlington NHS Foundation Trust is an acute Trust providing

ADDRESS: Trust Headquaters a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Darlington Memorial Hospital healthcare across County Durham and Darlington and surrounding areas from from all other proteins in Hollyhurst the cell orRoad organism they could help the hospitals, disease much crops and morealongside efficient biofuels, and in twodiagnose main acute at Durham and Darlington, other community Darlington hospitals. and studied in great detail.

Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to POSTCODE: DL3 6HX approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity.

The Foundation Trust provides secondary care hospital services from three main some important information.

Proteins do not the cause of the sites:disease, in which case they WEB: www.cddft.nhs.uk • Bishop Auckland General Hospital Of course much of this was promised from exist in isolation from each other, so although could act as targets against which new drugs Stephen Eames • Darlington Memorial Hospital studying pureCONTACT: proteins removes interference can be developed. the earliest days of proteomics, and it has • University Hospital of North Durham JOB ROLE: Chief Executive from other proteins it also reduces a lot of the to be said theBridge results so Chester-le-Street. far have not lived • The Trust also runs community hospitals in Shotley and 380100 TEL: 01325 complexity and interaction which is actually a up to expectations. This is in part because We provide services to the populationsthe of the Primary has had to catch up with key part of how proteins work. technology Care Trusts (PCTs) in County Durham and Darlington and the theory.

Some of the equipment used for also to other PCTs outside the patch.

Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic Durham Primary Care Trust (NHS County to discover more proteins, more accurately County Durham) ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to Launched on 1 October 2006 and serves a population of around 497,000, the

ADDRESS: John Snow House to map out all the proteins in any University given cellScience or handle the immensely andCounty complex data Durham Park new organisation replaces the five previous primary care trustslarge serving Couny Durham. organism, at a given time.

OnceDurham you can do generated by this research has also increased 3YG POSTCODE: this it enables you to trulyDH1 understand how the exponentially over the decade, and finally, but The functions of County Durham Primary Care Trust include: chemical building WEB: blockswww.countydurham.nhs.uk of life truly interact. perhaps most importantly, the people working • improving the health of the community and reducing health inequalities in the services field have had to develop and perfect • securing the provision of safe, high quality Yasminlike Chaudhry • contract management on behalf of new its general practices and public In a way, theCONTACT: genome is rather a dictionary techniques and methods to allow them • engaging with local people and other local service providers to ensure JOB ROLE Chief Executive which contains a list of all the possible words to generate and interpret robust reliable data. patients’ views are properly heard and coherent access to integrated health in a language, whereas proteome is more enquiries@cdpct.nhs.uk and social care services is provided EMAIL: the acting as can a provider of services only In where is not possible to have separate

individual books in that language, like the Since different• cell types be characterised manyit ways proteomics has finally caught providers TEL: 0191 3011300 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no • emergency planning.

FAX: 0191 3744103 needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 0 2 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

CREST (Centre for Rehabilitation and Engineering Studies)

ADDRESS: Newcastle University School of Mechanical and Systems Engineering Stephenson Building Claremont Road Newcastle upon Tyne POSTCODE: NE1 7RU CONTACT: Prof Garth Johnson JOB ROLE: Director EMAIL: g.r.johnson@ncl.ac.uk TEL: 0191 222 6196

A B C

CREST is an inter-disciplinary research group, based at Newcastle University, with an established International reputation in clinical rehabilitation and bioengineering.

CREST’s primary interests are centred on the fields of: • Upper limb biomechanics and assistive technology (Prof. Johnson) • Joint replacement and biotribology (Dr. Joyce) • Musculo-skeletal modelling and comparative biomechanics (Dr. Lawson)

D E F G

Darlington Primary Care Trust (PCT)

ADDRESS: Dr Piper House Kings Street Darlington POSTCODE: DL3 6JL WEB: www.darlingtonpct.nhs.uk

CONTACT: Colin Morris JOB ROLE: Chief Executive

H

Darlington Primary Care Trust (PCT) which is known as NHS Darlington, is the accountable organisation for commissioning and delivery of healthcare for the residents of Darlington. It also provides community health services for the residents of County Durham and Darlington.

I

It employs over 3000 staff who work across County Durham and Darlington.

J

The vision of NHS Darlington is to be an innovative and developing organisation that, in partnership, works to be the care provider of choice and deliver first class healthcare services which put patients and customers at the centre of all it does.

TEL: 01325 364271 FAX: 01325 746112

NEPAF (the North East Proteome Analysis Through Cels, NEPAF has a dedicated Facility) will work with a wide range of research team of six scientists, including experienced and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and will provide Dr Glen Kemp , project manager, NEPAFfor Care (EPICC) Enhancing Practice and Innovation Centre them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art ADDRESS: School of Health & Social Care facilities that allow even the smallest of Teeside University The facility will give clients access to expertise companies to carry out the research they Middlesbrough TS1 3BA for drug discovery, POSTCODE: in the use of proteomics need. NEPAF’s goal is to support companies development and manufacture and in the carrying out significant and, in some cases, WEB: www.tees.ac.uk/epicc The Enhancing Practice Innovation Centre for Care (EPICC), in the School diagnosis and monitoring of disease. ground-breaking research andand development of Health & Social Care, brings together the initiatives and innovations which usingenhance proteomics that will secure the CONTACT: Dr Terry Bearpark service user care.

Enterprise Fellow JOB ROLE: The facility provides a range of services reputation of the North East as the place to EPICCbusiness.” provides a single portal for all health and social care organisations to includingEMAIL: protein epicc@tees.ac.uk extraction, using one of the do biotech access the expertise of Teesside University to support the development of first pressure cycling homogenisers in the UK, Achimprofessional Treumann,practice scientificand manager ofdelivery through innovative thinking. service 738063 TEL: 01642 protein separation using 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use Working in partnership the distinctive signature of EPICC. We have a Gel Electrophoresis (2D-PAGE) and leading edge technology to isprovide solutions practical patient/user/practitioner focus aimed at making real changes and multi-dimensional liquid chromatography for real world biochemical problems. Our improvements in the care experience.

(MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and commercial The level Newcastle Fertilityresearch.

Centre different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures youis obtain Newcastle Fertility that Centre an NHSreliable facility within the Newcastle upon Tyne ADDRESS: Bioscience Centre Hospitals NHS Foundation Trust and is linked with the Royal Victoria Infirmary. capabilities for biomarker discovery, signal results and our scientists’ communication International Centre for Life The Centre is also closely associated with the leading UK Medical School at transduction pathway skills ensure that you will understand them. ” Times analysis, Square protein Newcastle University and has active research and teaching programmes.

Newcastle upon Tyne expression analysis, protein identification, POSTCODE: NE1 4EP The Newcastle Fertility quantification and characterisation.

For further information visit: Centre primarily provides help and support for couples who have problems related to fertility. Most couples in the North East can be www.nepaf.com WEB: www.newcastle-hospitals.org.uk/ seen as NHS patients and we are pleased to receive referrals via your GP. A services/fertility-centre.aspx/ With its main laboratory located on the fee paying service is available for those who are not eligible for NHS funded treatment. campus of Newcastle University and a CONTACT: Professor Alison Murdoch second located on the campus of of Department JOBlaboratory ROLE: Head Durham University, NEPAF is supported by 0191 2138213 the regionalTEL: development agency One North FAX: 0191 2138214 East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 0 3

A B

P R O T E O M I Gateshead C S FHealth U TNHSUFoundation R E Trust OF BIOTECHNOLOGY

C D

ADDRESS: Trust Headquaters Education Centre Queen Elizabeth Hospital Gateshead POSTCODE: NE9 6SX

WEB: www.gatesheadhealth.nhs.uk

The Trust provides a full range of local acute services for elective (planned) and emergency care including in-patient, out-patient, day case and day care. In addition, we provide sub-regional Breast Screening Services – covering Gateshead, South Tyneside, Sunderland and parts of Durham – and we are the North Eastern hub for the National Bowel Cancer Screening Programme.

This covers an area East of the Pennines stretching from the Scottish border to Humber, a population of around 7 million people.

CONTACT: Ian Renwick JOB ROLE: Chief Executive

E

EMAIL: contact.qe@ghnt.nhs.uk

F

TEL: 0191 4820000 FAX: 0191 482 6001

G Gateshead Primary Care Trust (PCT)

H I J K L M N O P Q R S T U V W X Y Z

ADDRESS: Team View 5th Avenue Business Park Team Valley Trading Estate Gateshead Tyne and Wear POSTCODE: NE11 0NB WEB: www.gatesheadpct.nhs.uk TEL: 0191 4915713

NHS South of Tyne and Wear covers Gateshead Primary Care Trust (PCT), South Tyneside Primary Care Trust (PCT) and Sunderland Teaching Primary Care Trust (TPCT) and is the name given to the integrated management arrangements which exist across the three PCTs. This means that, whilst each PCT remains a statutory organisation in its own right, the day-to-day management of the PCTs has been brought together under a single management team.

NHS South of Tyne and Wear works closely with local hospitals, social services and local GPs, dentists, pharmacists and optometrists to ensure local people receive high quality, seamless health services when and where they are needed. This means understanding the health needs of our population and commissioning services in line with these needs.

The term Proteomics was only coined changing as it ages and even in response to to give us important insights in the ageing around 14 years ago, making it a relatively changes from outside and within. process as a whole. So there are scientific new science. It was developed to address questions proteomics can help us answer, a key limitation in classical protein For example if you could compare the literally from cradle to grave. biochemistry. proteinsPrimary in a fit healthy cell from those(NHS in a What is more, since proteomics can Hartlepool Care Trust Hartlepool) diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural Covering a population of 93,000 people registered with GPs in 16 practices, the

ADDRESS: 1st Floor Mandale House a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Harbour Walk organisation’s aim is to improve the health and wellbeing of local people by from all other proteins in The the Marina cell or organism they could help diagnose crops and more efficient biofuels, and in working with the our disease partnersmuch and the public to achieve good health for everyone.

Hartlepool and studied in great detail.

Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to NHS Hartlepool aims to deliver the best possible health care to the people of POSTCODE: TS24 0US approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity.

Hartlepool. NHS Hartlepool is an innovative and developing organisation. We some important information.

Proteins do not the cause of the in commission which case first theyclass healthcare services, prevent ill health and are disease, working to WEB: www.hartlepoolpct.nhs.uk promote positive well being by putting Of patients customers at the centre of exist in isolation from each other, so although could act as targets against which new drugs courseand much of this was promised from Christine Willis all we do. Our vision is that the people of Hartlepool live longer, healthier lives. studying pureCONTACT: proteins removes interference can be developed. the earliest days of proteomics, and it has JOB ROLE: Chief Executive from other proteins it also reduces a lot of the to be said the results so far have not lived EMAIL: mynhshartlepool@nhs.net complexity and interaction which is actually a up to expectations. This is in part because of how proteins work. key part the technology has had to catch up with TEL: 01429 285079 the theory. Some of the equipment used for FAX: 01429 286944 Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Institute for Cell and Molecular Biosciences (ICaMB) ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: The Medical School to map out all the proteins in any given cell or handle the immensely large and complex data Newcastle University 2nd Floor, Catherine organism, at a given time.

Once you can do Cookson generated by this research has also increased this it enables you to trulyBuilding understand how the exponentially over the decade, and finally, but Framlington Place The Institute for Cell and Molecular Biosciences (ICaMB) carries out leading chemical building blocksNewcastle of life truly upon interact. perhaps most importantly, theworld people working Tyne research on a range of problems of basic biological science. Our aim is to answer in the field have had to develop and perfect POSTCODE: NE2 4HH key questions relating to fundamental cell science, using the broad range of In a way, the genome is rather like a dictionary techniques available at the Institute. new techniques and methods to allow them WEB: www.ncl.ac.uk/camb/ which contains a list of all the possible words to generate and interpret robust reliable data.

The research in ICaMB is cross kingdom and has relevance to various aspects of cell in a language, whereas the Jeffproteome Errington is more CONTACT: function, including: Director of Institute JOB ROLE: like the individual books in that language, Since different•cell can be In many ways has finally caught celltypes signalling • characterised control of gene expression • cellproteomics cycle • cell morphogenesis these do not contain all the words, only those • protein biologyfingerprint, (synthesis, maturation, secretion) by their own unique proteome up interactions, with itself, that is not to say there are no TEL: 0191 2228126 • functions ofstudy organelles needed to tell the story, way in which proteomics can be used to how and cell bodies more challenges to overcome, but we are 0191the 2227424 FAX: and • membrane transport of nutrients, electrolytes and xenobiotics those words interact dictates how the story embryonic stem cellsand canmolecular develop into • cell basisany of disease. now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 0 4 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Institute of Human Genetics (IHG)

B

ADDRESS: Newcastle Universtiy International Centre for Life Central Parkway Newcastle upon Tyne POSTCODE: NE1 3BZ WEB www.ncl.ac.uk/ihg CONTACT: Professor John Burn JOB ROLE: Director of Institute TEL: 0191 2418616 FAX: 0191 2418666

C The Institute of Human Genetics (IHG) is a Research Institute of Newcastle University. This status was awarded in 2001 in recognition of the award to the Institute of the highest possible grading (5*) in the national Research Assessment Exercise (RAE) that year.

Underpinning these achievements is a simple concept, one of partnership between basic human molecular and developmental genetics and clinical genetics, coupled with a determination to strive always for excellence. The IHG has over 30 academic staff including 15 Professors. Several of the new appointments will form the core of a new Stem Cell Institute being established jointly by Newcastle and Durham Universities.

James Cook University Hospital

ADDRESS: Marton Road Middlesbrough Cleveland POSTCODE: TS4 3BW TEL: FAX:

01642 850850 01642 854943

D E F G H

One of Europe’s most modern hospitals, The James Cook University site in Middlesbrough is the largest of its type with a wide range of district general hospital services and specialist (tertiary) services including neurosurgery, renal medicine, spinal injuries, major trauma, vascular surgery and cancer services. We have strong links with the Universities of Newcastle and Durham. As a university hospital, we do teaching and training and have a new clinical sciences research facility.

I J K

NEPAF (the North East Proteome Analysis Through Cels, NEPAF has a dedicated Facility) will work with a wide range of research team of six scientists, including experienced and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and will provideMagnetic Dr GlenResonance Kemp , project manager, NEPAF Centre (MRC) them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art ADDRESS: Newcastle University facilities that allow even the smallest of Campus for Ageing & Vitality The facility will give clients access to expertise companies to carry out the research they Newcastle upon Tyne NE4 5PL for drug discovery, POSTCODE: in the use of proteomics need. NEPAF’s goal is to support companies development and manufacture and in the carrying out significant and, in some cases, WEB: www.ncl.ac.uk/magres/ The mission of the Centre to develop and apply novel, non-invasive magnetic diagnosis and monitoring of disease. ground-breaking research and isdevelopment resonance methodology to solve important problems of human health. The using proteomics that will secure the CONTACT: Roy Taylor centre provides over 900m2 of laboratory space equipped with a high field Director JOB ROLE: The facility provides a range of services reputation of the North East asmagnetic the placeresonance to strength, state-of-the-art scanner and full facilities for clinicalbusiness.”

MR research and associated technical developments. includingEMAIL: protein roy.taylor@ncl.ac.uk extraction, using one of the do biotech first pressure cycling homogenisers in the UK, Achim Treumann, scientific manager of The centre represents an investment of more than £4.9million with capital 2481154 TEL: 0191 protein separation using 2-D Polyacrylamide NEPAF says: coming “Our aimfrom at NEPAF is to useincluding One North East, the Northern Rock funding many sources 0191 2481151 Foundation, Newcastle Healthcare Charity, the Catherine Cookson Charitable Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions Trust, HEFCE (SRIF2), the Barclay Foundation, Newcastle University and private multi-dimensional liquid chromatography for real world biochemical problems.

Our donations.

(MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and commercialCare research.

The level Middlesbrough Primary Trust (PCT) different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable Covering a population of 153,000 people registered in 22 GP practices, NHS ADDRESS: Riverside House capabilities for biomarker discovery, signal resultsMiddlesbrough’s and our scientists’ communication 18 High Force Road aim is to improve the health and wellbeing of local people. NHS transduction pathway analysis, skills ensure that youaims will understand them.

Riverside Park protein Middlesbrough to deliver the best”possible health care to the people of Middlesbrough Middlesbrough. expression analysis, protein identification, POSTCODE: TS2 1RH quantification and characterisation.

For further information visit: NHS Middlesbrough is an innovative and developing organisation. We are www.nepaf.com working to commission first class healthcare services, prevent ill health and WEB: www.middlesbroughpct.nhs.uk promote positive well being by putting patients and customers at the centre of With its main laboratory located on the mynhsmiddlesbrough@nhs.net all we do. Our vision is that the people of Middlesbrough live longer, healthier campus EMAIL: of Newcastle University and a lives. second laboratory located on the campus of TEL: 01642 352370 352380 FAX: 01642 Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 0 5

A B

P R O T E O M I C S FNewGene U T ULtdR E OF BIOTECHNOLOGY

C D E

ADDRESS: Bioscience Building International Centre For Life Newcastle upon Tyne POSTCODE: NE1 4EP WEB: www.newgene.org.uk

F

CONTACT: Jonathan Robinson JOB ROLE: Business Development Manager EMAIL: info@newgene.org.uk

NewGene is a molecular diagnostics and research services company. By combining next generation technologies with our significant technical capability and expertise in both genomics research and molecular diagnostics we are able to offer rapid and cost effective DNA and RNA sequencing and genotyping.

TEL: 0191 2421923 FAX: 0191 2418799

G Newcastle Biomedicine

H I

J

WEB: www.ncl.ac.uk/biomedicine/

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: The Medical School Newcastle University Framington Place Newcastle upon Tyne POSTCODE: NE2 4HH

CONTACT: Professor Chris Day JOB ROLE: Director EMAIL: biomedicine@ncl.ac.uk TEL: 0191 2226707

We are a world leading collaboration of research scientists, engineers, medical doctors and teaching professionals who deliver undergraduate and postgraduate teaching in medicine, dentistry and health sciences.

We are a recognised national centre of excellence who bring together internationally respected research in clinical care, basic science and engineering in an innovative environment. We excel in tackling challenges in health and healthcare.

changing as it ages and even in response to to give us important insights in the ageing Our key areas of focus include ageing, stem cells, cancer, cell biology, genetics, changes fromdrug outside and within. process as a whole. So there are scientific development, medicine in society, and neuroscience. questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteins in a fit healthy cell from thoseUnit in a (NCTU) What is more, since proteomics can Newcastle Clinical Trials diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural

ADDRESS: 21 Claremont Place a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Newcastle upon Tyne from all other proteins in NE2 the cell they could help diagnose the disease much crops and more efficient biofuels, and in 4AAor organism POSTCODE: and studied in great detail. Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to CONTACT: Professor Elaine McColl approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity.

JOB ROLE: Director The disease, remit of the Newcastle some important information. Proteins do not the cause of the in which caseClinical they Trials Unit (NCTU) is the design, conduct and analysis of a broad spectrum of clinical and complex trials of health, social e.mccoll@ncl.ac.uk exist in isolation EMAIL: from each other, so although could act as targets against which new drugs Of course much of this was promised from and educational interventions. As well as trials of all types of health and social

studying pure proteins removes interference can be developed. thescreening, earliest days of proteomics, and it has technologies – pharmacological, surgical, behavioural, social and TEL: 0191 2227260 service-level interventions – the NCTU also trials from other proteinsFAX: it also0191 reduces a lot of the tosupports be said intervention the results so faraimed have at not lived 2226043 improving clinical and service effectiveness through professional behaviour change. complexity and interaction which is actually a up to expectations. This is in part because key part of how proteins work. technology catch upservice with Our work is both proactive and reactivethe to the needs ofhas the had NHS to and other providers. We work collaboratively with clinicians and other in the the theory.

Some ofprofessionals the equipment used for Newcastle University, in other universitiesproteomics, and in health andas social trusts. mass Proteomics aims to redress this by embracing such highcare resolution the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic Newcastle Diabetes Centre to discover more proteins, more accurately ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to Newcastle Diabetes Centre was opened in June 1997 and serves all of the

ADDRESS: Newcastle General Hospital to map out all the proteins in any given handle the immensely large and complex data people of the city of Newcastle Upon Tyne.

Westgate Roadcell or Newcastle Tyne organism, at a given time.

Once youupon can do generated by this research has also increased The philosophy of the Diabetes Centre is to provide a high quality, equal 6BE POSTCODE: this it enables you to trulyNE4 understand how the exponentially over the decade, and finally, but access and seamless service for all patients with diabetes, whether in primary or chemical building blocks of life truly interact. perhaps most importantly, the people working secondary care.

0191 2336161 TEL: in the field have had to develop and perfect In a way, the genome is rather like a dictionary new techniques and methods to allow them which contains a list of all the possible words to generate and interpret robust reliable data. in a language, whereas the proteome is more like the individual books in that language, Since different cell types can be characterised In many ways proteomics has finally caught these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

1 0 6 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Newcastle NIHR Clinical Research Facility (CRF)

ADDRESS: Clinical Research Facility 4th Floor Leazes Wing Royal Victoria Infirmary Queen Victoria Road Newcastle POSTCODE: NE1 4LP CONTACT: Jane Barnes EMAIL: jane.barnes@ncl.ac.uk

A purpose built research facility, its purpose is to provide dedicated patientcare facilites and practical support to researchers carrying out clinical research, as well as providing a platform to support researchers in developing and conducting research projects to world-class standards.

B C

Studies conducted so far have supported the following specialties: Oncology, Haematology, Endocrinology, Immunology, Cardiovascular, Rheumatology, Nutrition, Hepatology, Neurosciences, Nephrology, Haematology oncology, Genetics, Neuromuscular and Paediatrics

TEL: 0191 2820070 FAX: 0191 2820064

D E F G

Newcastle Primary Care Trust (PCT)

ADDRESS: Benfiled Road Newcastle POSTCODE: NE6 4PF WEB: www.newcastlepct.nhs.uk TEL: 0191 2196000 FAX: 0191 2196066

H

As a PCT we have four core functions on which our corporate objectives are based: • Provide a wide range of healthcare services, employing hundreds of health professionals • Provide support to independent family doctors, dentists, pharmacists and opticians • Commission and pay for hospital services and other specialist services • Work with other organisations and community groups to improve services, tackle health inequalities and improve health.

Our main providers of services are Northumbria Healthcare NHS Foundation Trust, Newcastle upon Tyne Hospitals NHS Foundation Trust, Northumberland, Tyne and Wear NHS Trust and North East Ambulance Service NHS Trust.

NEPAF (the North East Proteome Analysis Through Cels, NEPAF has a dedicated Facility) will work with a wide range of research team of six scientists, including experienced and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and will provide Dr Glen Kemp , project manager, Newcastle upon Tyne Hospitals NHSNEPAF Foundation Trust them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art We’ve been providing patient-centred healthcare to communities in the North

ADDRESS: Freeman Hospital facilities that allow even the smallest of East of England and beyond for over 250 years. We’re one of the largest NHS Freeman Road The facility will give clients access to expertise companies carry the research they of specialist services than any other. From trusts intothe UK,out offering a wider range High Heaton elderly and infirm, our aim is to deliver leading-edge Newcastle in the use of proteomics for drug discovery, need.newborn NEPAF’sbabies goal is to to the support companies healthcare with a and, personal touch.

7DN POSTCODE: development andNE7 manufacture and in the carrying out significant in some cases, diagnosis and monitoring of disease. ground-breaking research and development We deliver healthcare services from seven major sites: WEB: www.newcastle-hospitals.org.uk using •proteomics that will secure the Freeman Hospital • Royal Victoria (RVI)place to Sir Leonard CONTACT: The facility provides a range RofFenwick services reputation of the NorthInfirmary East as the • Newcastle General Hospital (NGH) JOB ROLE: Chief Executive including protein extraction, using one of the do biotech business.”

• Newcastle Dental Hospital first pressure cycling in the UK, Achim• Treumann, manager of Newcastlescientific Fertility Centre 0191homogenisers 2336161 TEL: • says: Northern Serviceis to use protein separation using 2-D Polyacrylamide NEPAF “OurGenetics aim at NEPAF • Walkergate Hospital Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and commercial NHS Directresearch. The level different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable We are not just a telephone health line - NHS Direct also offer commissioned

ADDRESS: Sterling House capabilities for biomarker discovery, signal resultsservices and our scientists’ communication Newcastle upon Tyne to other parts of the NHS to help them meet their patients’ needs. transduction pathway analysis, protein skills ensure that you will understand them. ” NE12 8EW POSTCODE: These services include: expression analysis, protein identification, • out of hours support for GPs and dental services, CONTACT: Veronica Sanderson quantification and characterisation.

For further information visit: • telephone support for patients with long-term conditions,

www.nepaf.com • pre and post operative support for patients, EMAIL: Veronica.Sanderson@nhsdirect. nhs.uk located on the • 24 hour response to health scares, and With its main laboratory • remote clinics via telephone.

TEL: campus of Newcastle University and a 0191 2381107 second laboratory located on the campus of The vision is to be the national healthline, providing expert health advice, information and reassurance, using our world class telephone service and Durham University, NEPAF is supported by website, and to be the NHS’ provider of choice for the regional development agency One North telephone and digitally delivered health services East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

I J K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 0 7

A B

P R O T E O M INorth C East S Strategic FUT U Authority R E (SHA) Health OF BIOTECHNOLOGY

C

ADDRESS: Waterfront 4 Goldcrest Way Newcastle upon Tyne POSTCODE: NE15 8NY

WEB: www.northeast.nhs.uk

D

North East Strategic Health Authority is responsible for making sure that health services in the region are fit for purpose, well planned, high quality and meet all Department of Health targets. With around 200 staff we are responsible for making sure that all NHS services in our region are meeting the highest possible standards. NHS North East is what we call the collective of 23 individual NHS organisations in the region. We are one of ten strategic health authorities in England and are accountable to the Department of Health. We are a regional body and, as such, play a pivotal role in implementing national Department of Health policies in the north east.

CONTACT: Ian Dalton JOB ROLE: Chief Executive

E

TEL: 0191 2106400 FAX: 0191 2106401

F G

North East Ambulance Service NHS Trust

H I J K L M N O P Q R S T U V W X Y Z

ADDRESS: Bernicia House Goldcrest Way Newburn Riverside Newcastle POSTCODE: NE15 8NY

The new North East Ambulance Service NHS Trust was formed on the 1st July 2006 following the merger of the previous North East Ambulance Service and part of the Teesside, East and North Yorkshire Ambulance Trust. The new service now covers the counties of Northumberland, Tyne and Wear, Durham and Teesside, an area of approximately 3,230 square miles. The trust employs 1750 people and serves a population of 2.6 million.

WEB: www.neambulance.nhs.uk TEL: 0191 4302000

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteins in aEast fit healthy cell from those inat a WorkWhat is more, since proteomics can North Better Health diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences.

These different proteins may just increasingly being used in agricultural ADDRESS: Room 1-308 a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Gateshead College Campus from all other proteins in Baltic the cell or organism they could help diagnose the disease much crops and more efficient biofuels, and in Quarryfield Road and studied in great detail.

Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to Baltic Business Quarter approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity.

Gateshead NE8 3BE POSTCODE: some important information.

Proteins do not the cause of the disease, in which case they Partnership between and NHS to provide exist in isolation from each other, so although could act as targets against whichGateshead new drugs College Of course much of this information, was promised from WEB: www.nebetterhealthatwork.nhs.uk guidance, training and support for employers in Gateshead, South Tyneside and studying pure proteins removes interference can be developed. the earliest days of proteomics, and it has Sunderland who want to improve their health of their workforce. Signposting Neville CONTACT: from other proteins it alsoKerry reduces a lot of the to be said to thepromote results so far have not lived employers and employees to health information healthier lifestyle

choices. See website for support in other complexity and interaction which is actually a up areas. to expectations. This is in part because EMAIL: betterhealthatwork@gateshead. key part work. the technology has had to catch up with of how proteins ac.uk the theory. Some of the equipment used for 0191this 4902419 Proteomics aims toTEL: redress by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately North East Public Health Observatory ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Wolfson Research Institute to map out all the proteins in any University given cell or handle the immensely large and complex data Durham Queen’s Campus organism, at a given time.

Once you can do generated by this research has also increased Boulevard this it enables you to trulyUniversity understand how the exponentially over the decade, and finally, but Stockton on Tees chemical building blocks of life truly interact. perhaps most importantly, the people working TS17 6BH POSTCODE: in the field have had to develop and perfect www.nepho.org.uk The North East Public Health Observatory (NEPHO) is oneand of nine regional Public WEB:is rather In a way, the genome like a dictionary new techniques methods to allow them Health Observatories in England. Public Health Observitories respond to regional which contains a list of all the possible words to generate and interpret robust reliable data. and local health intelligence needs, and collectively produce key national CONTACT: Susan Panrucker in a language, whereas proteome is more Business Manager outputs.

JOB ROLE: the like the individual books in that language, Since different cell types can be characterised In many ways proteomics has finally caught EMAIL: susan.panrucker@durham.ac.uk these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no

needed to tell the story, way in which proteomics can be used to study how more challenges to overcome, but we are 0191the 3340398 TEL: and those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

1 0 8 C E L S H E A LT H C O N N E C T

changing as it ages and even in response to changes from outside and within.

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

North Tees and Hartlepool NHS Foundation Trust

ADDRESS: Hardwick Road Stockton POSTCODE: TS19 8PE WEB: www.nth.nhs.uk TEL: 01642 617617

We provide hospital-based health care to around 365,000 people living in East Durham, Hartlepool, Stockton on Tees surrounding areas and part of Sedgefield.

Our breast and bowel screening service extends further than this taking the total population we serve for screening services to around 400,000.

B C

We have two hospitals • The University Hospital of North Tees (formerly North Tees General Hospital) • The University Hospital of Hartlepool (formerly Hartlepool General Hospital) We also provide a small number of outpatient and outreach clinics at Peterlee Community Hospital.

D E F G

North Tees Primary care Trust (PCT)

ADDRESS: Teesdale House Westpoint Road Thornaby Stockton POSTCODE: TS17 6BL WEB: www.northteespct.nhs.uk

H

Covering a population of 186,000 people registered in 27 GP practices, 26 dental practices, 28 pharmacies and 14 ophthalmic practices, the organisation’s aim is to improve the health and wellbeing of the local population by working with our partners and public to achieve good health for everyone.

NHS Stockton on Tees aims to deliver the best possible health care to the people of Stockton borough.

I J K

TEL: 01642 2666700

NEPAF (the North East Proteome Analysis Through Cels, NEPAF has a dedicated Facility) will work with a wide range of research team of six scientists, including experienced and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and will provide Dr Glen Kemp , project manager, NEPAF (PCT) North Tyneside Primary Care Trust them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art North Tyneside Primary Care Trust (PCT) is responsible for commissioning (buying)

ADDRESS: Bevan House facilities that allow even the smallest of 1 Esh Plaza and providing health care services for the borough’s 213,000 residents The facility will give clients access to expertise companies carry outthere the research they practices, 32 dental practices, 51 Sir Bobby Robson Way In NorthtoTyneside are 28 general Great Park pharmacies and 14 optical practices. in the use of proteomics for drug discovery, need.community NEPAF’s goal is to support companies Newcastle development and manufacture and in the carrying out significant and, in some cases, Our main providers of services are Northumbria Healthcare NHS Foundation Trust, POSTCODE: NE13 9BA diagnosis and monitoring of disease. ground-breaking research development Newcastle upon Tyne and Hospitals NHS Foundation Trust, Northumberland, Tyne and usingWear proteomics that willNorth secure NHS Trust and Eastthe Ambulance Service NHS Trust.

WEB: www.northtynesidepct.nhs.uk The facility provides a range of services reputation of the North East as the place to TEL: 0191 2172500 including protein extraction, using one of the do biotech business.”

0191 2172501 FAX: first pressure cycling homogenisers in the UK, Achim Treumann, scientific manager of protein separation using 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and commercial research.

The level Northumberland Care Trust different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable Northumberland Care Trust is responsible for planning, delivering and purchasing

ADDRESS: Headquaters capabilities for biomarker discovery, signal results and our scientists’ communication Merley Croft the right health care for local residents. We pay for services provided by hospital transduction pathway analysis, protein skills trusts ensure that will understand them.

Loansdean and theyou ambulance trust and we ”have contracts with GPs, pharmacists, Morpeth dentists and opticians to make sure the right services are in place for local expression analysis, protein identification, people POSTCODE: NE61 2DL quantification and characterisation.

For further information visit: www.nepaf.com WEB: www.northumberland caretrust.nhs.uk With its main laboratory located on the campus of Newcastle University and a TEL: 01670 394400 second laboratory located on the campus of Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 0 9

A B

PROTEOM I C S FTyne U&TWear UNHS R Foundation E Northumberland, Trust OF BIOTECHNOLOGY

C D

ADDRESS: St Nicholas Hospital Jubilee Road Gosforth Newcastle POSTCODE: NE3 3XT

Northumberland, Tyne & Wear NHS Foundation Trust is one of the largest mental health and disability Trusts in England employing more than 7,000 staff, serving a population of approximately 1.4 million, providing services across an area totalling 2,200 square miles.

We work from over 160 sites across Northumberland, Newcastle, North Tyneside, Gateshead, South Tyneside, Sunderland and North Easington. We also have a number of regional and national specialist services.

WEB: www.ntw.nhs.uk TEL: 0844 8115522

E F G Northumbria Healthcare NHS Foundation Trust

H I J K L M N O P Q R S T U V W X Y Z

ADDRESS: North Tyneside General Hospital Rake lane North Shields POSTCODE: NE29 8NH WEB: www.northumbria.nhs.uk CONTACT: Jim Mackey JOB ROLE: Chief Executive EMAIL: switchboard@northumbria.nhs.uk

Northumbria Healthcare NHS Foundation Trust is geographically one of the largest trusts in the country. It provides healthcare to over half a million people across North Tyneside and Northumberland.

With a budget of £270 million and over 6,000 staff, it delivers a range of services to over 350,000 patients per year. The services provided include: accident and emergency care, maternity and children’s services, elective surgery including specialist orthopaedic and keyhole surgery and intensive care.

The Trust offers fast access to first-class diagnostic services and provides these services in some of the newest and most modern hospitals in the north east.

TEL: 0191 2934091 FAX: 0844 8118111

The term Proteomics was only coined changing as it ages and even in response to to give us important insights in the ageing around 14 years ago, making it a relatively changes from outside and within. process as a whole. So there are scientific new science. It was developed to address questions proteomics can help us answer, a key limitation in classical protein For example if you could compare the literally from cradle to grave. biochemistry. proteins in a fit healthy cell from those in a(PET) Centre What is more, since proteomics can Positron Emission Tomography diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural A clinical PET-CT scanner (Siemens Biograph-40) was purchased by Newcastle

ADDRESS: Clinical Research Platforms a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to helpby develop better food University and installed in spring 2007.

It was primarily funded the regional Newcastle University development agency, One North East. crops and more efficient biofuels, and in from all other proteins inNewcastle the cell or upon organism they could help diagnose the disease much Tyne NE1Although 7RU and studiedPOSTCODE: in great detail. this earlier, and thus improve the prognosis for microbiology to both fight microbes and to The Newcastle PET-CT scanner is primarily for academic and commercial approach remains very valuable it misses out the patient, or the different proteins may be harness amazing research applications. In the initial phase, these their are likely to bediversity. mostly cancer CONTACT: Beverly Hailstone studies.

The scanner will be temporarily located in the second scanner some important Proteins do not the cause of research the disease, in which case they manager JOB information.

ROLE: Administration of the Newcastle Centre on the Generalfrom exist in isolation from each other, so although could act as hall targets against whichMagnetic new drugsResonance Of course much of Newcastle this was promised Hospital site, and a support building has been provided on the adjacent site for beverly.hailstone@ncl.ac.uk EMAIL: removes studying pure proteins interference can be developed. the earliest days of proteomics, andofit has the dispensing of Positron Emission Tomography (PET) tracers and injection

from other proteinsTEL: it also reduces a lot of the to be saidPositron the results so farTomography have not lived patients. These facilities make up the Newcastle Emission 0191 2481150 Centre, one of the Newcastle Biomedicine Research Platforms. complexity and interaction which is actually a up toClinical expectations.

This is in part because Operation of the PET-CT scanner involves substantial co-operation between key part of how proteins work. the technology has had to catch up with Newcastle University and the NHS, especially the Regional Medical Physics theCancer theory.Care Some. of the equipment used for Department and the Northern Centre for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the geneticRedcar & Cleveland Primary Care Trustto(PCT) discover more proteins, more accurately ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to Covering a population of over 135,000 people registered in 23 GP practices, NHS

ADDRESS: Langbaurgh House to map out all the proteins in Street any given cell or handle immensely large and complex Bow Redcar and Cleveland’s aim is to improve the the health and wellbeing of the local data Guisborough population by working with our partnersgenerated and public achieve good for organism, at a given time.

Once you can do bytothis research hashealth also increased TS14 7AA everyone.

POSTCODE: this it enables you to truly understand how the exponentially over the decade, and finally, but chemical building WEB: blockswww.tees-pcts.nhs.uk/rcpct.asp of life truly interact. perhaps most importantly, people working NHS Redcar and Cleveland aims to deliver the best possible healththe care to local in the field have had to develop and perfect people.

EMAIL:is mynhsredcarandclevelandnhs.net In a way, the genome rather like a dictionary new techniques and methods to allow them

which contains a list of all the possible words to generate and interpret robust reliable data.

TEL: 01287 284400 in a language, whereas the proteome is more like the individual books in that language, Since different cell types can be characterised In many ways proteomics has finally caught these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 1 0 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Sir Bobby Robson Cancer Trials Research Centre

ADDRESS: Freeman Hospital Freeman Road High Heaton Newcastle upon Tyne POSTCODE: NE7 7DN CONTACT: Dr Julie Charlton JOB ROLE: Centre Manager EMAIL: j.a.charlton@ncl.ac.uk

The Sir Bobby Robson Cancer Trials Research Centre, based in the Northern Centre for Cancer Care (NCCC) at Freeman Hospital, is staffed by site-specialist researchers and provides: • protocol development and advice • regulatory and ethics submission • 10 years experience in working with commercial and academic partners • experience in all phases of research, including phases I-IV drug studies • enrolment, treatment, data management and follow-up reviews for the 20+ consultant clinical and medical oncologists, nurses and PAMs within the NCCC.

B C D E F G

South Tees Hospitals NHS Foundation Trust

ADDRESS: The James Cook University Hospital Marton Road Middlesbrough Cleveland POSTCODE: TS4 3BW WEB: www.southtees.nhs.uk CONTACT: Simon Pleydell JOB ROLE: Chief Executive

H

South Tees is one of the largest employers in the Tees Valley area with a workforce of around 7,000 staff and is a great place to work.

Our mission statement is ‘striving for the best in healthcare’ and we are proud of the hard work, commitment and dedication of our staff at both The James Cook University Hospital and the Friarage Hospital. Our overall strategy to achieving this is centred on four key themes (corporate objectives) which are: • Quality of care and patient safety (our top priority) • Organisational capability (investing in our staff) • Business sustainability (balancing the books/responding to change) • Partnerships and engagement

TEL: 01642 2850850

NEPAF (the North East Proteome Analysis Through Cels, NEPAF has a dedicated Facility) will work with a wide range of research team of six scientists, including experienced and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationallySouth and will provide Dr Glen NHS Kemp ,Trust project Clinical manager, NEPAF Tees Hospitals Research Facility them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art South Tees Hospitals NHS Trust Clinical Research Facility was formally established

ADDRESS: The James Cook University facilities that allow even the smallest of Hospital in April 2006. Located in the Academic Centre, James Cook University Hospital, The facility will give clients access to expertise companies toalready carry out thearesearch theyrecord of participation in high-quality national Marton Road the unit had strong track Middlesbrough field ofcompanies diabetes. Other specialties within the Trust are now in the use of proteomics for drug discovery, need.research NEPAF’sstudies goal isintothe support utilising the facilities. development andCleveland manufacture and in the carrying out significant and, in some cases, POSTCODE: TS4 3BW diagnosis and monitoring of disease. ground-breaking researchaand development The facility employs manager, nurses and clerical staff to support projects. A usingClinical proteomics willissecure the in the unit. All staff are Good Clinical Practice Trials that Officer also based WEB: www.southtees.nhs.uk (GCP)oftrained.

The facility provides a range of services reputation the North East as the place to CONTACT: Simon Pleydell including protein extraction, using one of the do biotech business.”

Chief Executive JOB ROLE: first pressure cycling homogenisers in the UK, Achim Treumann, scientific manager of TEL: 01642 protein separation using2850850 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six South academic and commercial research. TheTrust level Tyneside NHS Foundation different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable Although a comparatively small provider of hospital services by today’s

ADDRESS: South Tyneside District Hospital capabilities for biomarker discovery, signal resultsstandards, and our scientists’ communication Harton Lane South Tyneside NHS Foundation Trust is consistently ranked as one of transduction pathway skills ensure youorganisations will understand them. ” Southanalysis, Shields protein the bestthat by the which inspect and regulate us. The Healthcare Tyneprotein and Wear Commission, the independent body which inspects us, gave us ratings of expression analysis, identification, ‘Excellent’ for the quality of our services and ‘Excellent’ for the use of resources.

POSTCODE: NE34 0PL quantification and characterisation.

For further information visit: www.nepaf.com Our mission is to provide a comprehensive range of high quality health care WEB: www.sthct.nhs.uk services in our hospitals, clinics or at home to meet the needs of the local With its main laboratory located on the Lorraine Lambertand a population and others who wish to make use of our services.

CONTACT: campus of Newcastle University JOB ROLE: Chief Executive second laboratory located on the campus of 4041000 TEL: 0191 Durham University, NEPAF is supported by 0191 2022197 the regionalFAX: development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

I J K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 1 1

A B

South Tyneside Primary Care Trust

C D

ADDRESS: Clarendon Windmill Way Hebburn Tyne and Wear POSTCODE: NE31 1AT

HS South of Tyne and Wear covers Gateshead Primary Care Trust (PCT), South Tyneside Primary Care Trust (PCT) and Sunderland Teaching Primary Care Trust (TPCT) and is the name given to the integrated management arrangements which exist across the three PCTs. NHS South of Tyne and Wear covers the same area as Gateshead, South Tyneside and Sunderland Local Authorities and is responsible for spearheading improvements to the health of local people. NHS South of Tyne and Wear works closely with local hospitals, social services and local GPs, dentists, pharmacists and optometrists to ensure local people receive high quality, seamless health services when and where they are needed. This means understanding the health needs of our population and commissioning services in line with these needs.

WEB: www.stpct.nhs.uk TEL: 0191 2831000 0191 2831001

E F G

Sunderland Teaching Primary Care Trust

H I J K L M N O P Q R S T U V W X Y Z

ADDRESS: Pemberton House Colima Avenue Sunderland Enterprise Park Sunderland POSTCODE: SR5 3XB

NHS South of Tyne and Wear covers Gateshead Primary Care Trust (PCT), South Tyneside Primary Care Trust (PCT) and Sunderland Teaching Primary Care Trust (TPCT) and is the name given to the integrated management arrangements which exist across the three PCTs. This means that, whilst each PCT remains a statutory organisation in its own right, the day-to-day management of the PCTs has been brought together under a single management team.

WEB: www.sunderlandtpct.nhs.uk TEL: 0191 5297000 FAX: 0191 5297001

The term Proteomics was only coined changing as it ages and even in response to to give us important insights in the ageing around 14 years ago, making it a relatively changes from outside and within. process as a whole. So there are scientific new science. It was developed to address questions proteomics can help us answer, a key limitation in classical protein For example if you could compare the literally from cradle to grave. biochemistry. proteins a fit healthy cell fromNHS those in a What is more, since proteomics can Tees, Esk andin Wear Valleys Foundation Trust diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural Tees, Esk and Wear Valleys NHS Trust was created in April 2006, following the

ADDRESS: West Park Hospital a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Edward Pease Way merger of County Durham and Darlington Priority Services NHS Trust and Tees and from all other proteins in Darlington the cell or organism they could help diagnose the disease muchWe provide crops and more efficient biofuels, and in North East Yorkshire NHS Trust. a range of mental health, learning County Durham disability andthe substance misuse for the 1.3 million people living in County and studied in great detail.

Although this earlier, and thus improve prognosis for servicesmicrobiology to both fight microbes and to Durham, the Tees Valley and the Scarborough, Whitby and Ryedale areas of POSTCODE: DL2 2TS approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity.

North Yorkshire. With 5,000 staff and an annual income of £220m we deliver our some important information.

Proteins do not the cause of the disease, in which they with seven local authorities and primary care services by working in case partnership WEB: www.tewv.nhs.uk trusts, a against wide range ofnew voluntary as much well asofservice users, their carers exist in isolation from each other, so although could act as targets which drugsorganisations, Of course this was promised from 01325 5552000 and the public. The services are spread over a wide geographical area which TEL: removes studying pure proteins interference can be developed. the earliest days of proteomics, and it has includes coastal, rural and industrial areas. from other proteins it also reduces a lot of the to be said the results so far have not lived complexity and interaction which is actually a up to expectations. This is in part because key part of how proteins work. the technology has had to catch up with the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Wilson Horne Immunotherapy Centre ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to The Wilson Horne Immunotherapy Centre is part of the Clinical Research Facility ADDRESS: Newcastle Medical Centre to map out all the proteins in any given cell or handle theUK. immensely and of complex data Claremont Road and is the first dedicated centre of its kind in the It is at thelarge forefront the Newcastle Tyne development of tolerogenic therapies generated as well as providing an additional focus organism, at a given time.

Once youupon can do by this research has also increased and Wear for immunology in the region, attracting talented individuals an interest in this it enables you to trulyTyne understand how the exponentially over thewith decade, and finally, but manipulating the human immune system for therapy of diseases as diverse as POSTCODE: NE1 7RG chemical building blocks of life truly interact. perhaps most importantly, the people working rheumatoid arthritis and cancer. in the field have had to develop and perfect CONTACT: Jane Barnes In a way, the genome is rather like a dictionary new techniques and methods to allow them EMAIL: jane.barnes@ncl.ac.uk which contains a list of all the possible words to generate and interpret robust reliable data. in a language, whereas proteome 0191 2322973 is more TEL: the like the individual books in that language, Since different cell types can be characterised In many ways proteomics has finally caught these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 1 2 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

It is now possible to fit a computer screen to the visual system of the user; delivering increased user comfort, greater efficiency, less stress, fewer headaches, less downtime and greater user performance You would expect management decisions to be based upon performance measurement and now they can be

ROTTERDAM HOUSE l

...a tolerant computer screen can really be in the eye of the beholder

OMNIREAD GROUP LIMITED

WWW.OMNIREADGROUP.COM

l

“TRUST ME, YOU’LL HAVE TO SEE IT TO BELIEVE IT”

NEWCASTLE UPON TYNE

l

NE1 3DY

l

Be decisive and release the talents of your staff. They are the real ‘cels’ of your organisation – take care of them.

TELEPHONE 0191 206 4128

We assume that what we see is ‘what is’…and what we experience is normal! We spend a fortune on computer equipment and expect people’s eyes to live with what we give them - badly fitting safety equipment would not be tolerated in the workplace

500,000 sq ft of serviced office and laboratory space with scale up facilities Wide range of vacant space, units available from 100 sq ft to 30,000 sq ft Flexible leasing terms with immediate occupancy 1600 free car parking spaces Conference facilities and video conferencing studio Voice and Data Services

www.wiltoncentre.com

Telephone: 01642 438050

Wilton Centre continues to attract new R&D tenants One of the Tees Valley’s most respected research and development complexes continues to attract leading edge companies.

Convenient location, high specification office and research space and continuous improvement of services and on-site facilities have all helped The Wilton Centre develop into one of the most sought-after business bases in the North East.

Situated on Teesside between the Wilton International site and the picturesque Cleveland Hills, The Wilton Centre is only 10 minutes from the centre of Middlesbrough and within easy reach of the A1(M) and other key transport links, including Durham Tees Valley airport and the East Coast mainline railway.

Its range of office, laboratory and pilot plant/scale up accommodation, set in a 75-acre landscaped park with its own lake and courtyards – not to mention a secure 1600-space car park – is currently home to almost 50 companies, including a number of prestigious multinationals. Built by its former owners ICI in 1975, the Wilton Centre has long been an international flagship operation for chemical

1 1 4 C E L S H E A LT H C O N N E C T

research and development carried out on Teesside.

Since it changed hands in 1999 the Wilton Centre has had a significant amount of investment ploughed into updating and upgrading the facilities it offers including, most recently, the communal areas such as the reception, exhibition space, and the restaurant and cafe area.

The latter offers a wide choice of home-made produce and international cuisine, with nutritional information supplied for diners wanting to know more about the food they are enjoying. Working lunches, buffets and formal dinners can also be provided at most locations within the centre, while a ‘take away’ option is now also available for those requiring quick service.

With a track record of experience and expertise built on 35 years of scientific and technical achievement and complemented by a plentiful array of modern office and laboratory space, the Wilton Centre is the location of choice for any business or organisation looking for firstclass technical and office facilities.

Further information is available at www.wiltoncentre.com

be well, connected

Driving the business of life sciences

H E A LT H I N F O R M AT I C S

A B

P R O T E O M I C SApolloFMedical UTU R ELtd Systems OF BIOTECHNOLOGY

C D

ADDRESS: Business and Innovation Centre Sunderland Enterprise Park Wearfield Sunderland Tyne and Wear POSTCODE: SR5 2TA WEB: www.apollo-medical.com

E

F

Apollo Medical Systems was set up in 2000 to support the growing need of the Primary Care sector for accurate audit of patient clinical data. Today Apollo are the leading supplier of data audit services to Primary Care.

CONTACT: Steve Avery JOB ROLE: Director

Apollo have two main areas of expertise, audit and document management.

Our end users are mainly Primary Care computer system users i.e. General Practitioners, their staff and those that support them such as Practice Based Commissioning groups (PBC’s), Primary Care Trusts (PCT’s) and the Department of Health (DoH).

EMAIL: sales@apollo-medical.com TEL: 0191 5166694 FAX: 0191 5166695

G Ascari Ltd

H I

J

WEB: www.ascari-it.com

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: Quorum 16 Quorum Business Park Benton Lane Newcastle POSTCODE: NE12 8BX

CONTACT: Tim Matsell JOB ROLE: Information Systems Specialist EMAIL: tm@ascari-it.com TEL: 0203 070 2465

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

Ascari provide a wide range of specialist professional services for introducing information technology and information systems into organisations. We provide enabling technology to help organisations large and small achieve productivity improvements, increased efficiencies, operational control and regulatory compliance.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit healthy cell from those in a BioSignatures diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: Keel House a small number of proteins are separated out be a symptom of the disease, in which case Garth Heads from all other proteins in Newcastle the cell or organism they could help diagnose the disease much upon Tyne NE1Although 2JE and studiedPOSTCODE: in great detail. this earlier, and thus improve the prognosis for approach remains very valuable it misses out the patient, or the different proteins may be WEB: www.biosignatures.com some important information. Proteins do not the cause of the disease, inwas which they Biosignatures spuncase out of Nonlinear Dynamics Ltd in 2008 to use unique Willother, Dracup CONTACT: exist in isolation from each so although could act as targets which new drugs in Nonlinear Of coursetomuch of products this was promised insights against and technoogy developed create for clinicalfrom

ROLE: Chairman diagnostics. studying pureJOB proteins removes interference can be developed. the earliest days of proteomics, and it has from other proteins it alsowill.dracup@nonlinear.com reduces a lot of the to be said the results so far have lived EMAIL: Biosignatures are developing next generation molecular diagnostic tests not to arm

complexity and interaction which is actually a upexceptionally to expectations.

This istools in part because clinicians and healthcare providers with accurate for the TEL: 0191 rapid diagnosis of disease. This means treatment plans has for patients affected by key part of how proteins work.2302121 the technology had to catch up with a disease can be administered with greater confidence - drastically improving the theory.

Some of the equipment used for patient care.

Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Clarity Informatics ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: First Floor to map out all the proteins in any given cell or handle the immensely large and complex data Bede House AllOnce Saintsyou Business Centre organism, at a given time. can do generated by this research has also increased upon Tyne this it enables you to trulyNewcastle understand how the exponentially over the decade, and finally, but POSTCODE: NE1 2ES chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect WEB: www.clarity-informatics.com Clarity Informatics is a world-leading provider of health informatics products In a way, the genome is rather like a dictionary new techniques and methods to allow them and services. Clarity provides health software that millions of people use every CONTACT: Prof Ian Purves which contains a list of all the possible words to generate and interpret robust reliable data. month, world leading knowledge-bases, decision support and innovative health JOB ROLE: CEO in a language, whereas the proteome is more information systems design and implementation. Clarity was the UK Department ian.purves@schin.co.uk Trade andcan Industry Technology SME of year in 2005 like the individualEMAIL: books in that language, Since differentofcell types be characterised In the many ways proteomics has finally caught these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no TEL: 0191 2436100 needed to tell the story, way in which proteomics can be used to study how more challenges to overcome, but we are 0191the 2436101 FAX: and those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 1 6 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Daista Software Ltd

WEB: www.daistasoftware.com

B

ADDRESS: Gateshead International Business Centre Mulgrave Terrace Gateshead Tyne and Wear POSTCODE: NE8 1AN

CONTACT: Dr Kais Al-Timimi JOB ROLE: Director

C Daista Software Limited was founded in 2006 by Dr Kais Al-Timimi, to develop open data integration and interoperability solutions for reducing through-life costs and enhancing business performance.

D E

EMAIL: kais.al-timimi@daistasoftware.com

F

TEL: 01223 572579 FAX: 01223 571950

G Datatrial

WEB: www.datatrial.com

H

ADDRESS: Mikasa House Asama Court Newcastle Business Park Newcastle upon Tyne Tyne and Wear POSTCODE: NE4 7YD

CONTACT: Adam Black JOB ROLE: Managing Director

EMAIL: adam.black@datatrial.com NEPAF (the North East Proteome Analysis TEL: 0191 2263500

Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

I J Datatrial provides clinical data solutions for clinical trials. These services range from the design and planning of a clinical trial , all the necessary data collection and validation, through to statistical analysis and reporting. The company has its own Electronic Data Capture (EDC) software and is also an Oracle Partner with a range of Oracle Clinical services available. .

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

K L M

Dr Glen KempInformatics , project manager,Ltd NEPAF ePitope says: “The UK’s biotechnology sector is growing and in order for this growth to art

ADDRESS: Top Floor facilities that allow even the smallest of 11 Market Street The facility will give clients access to expertise companies to carry out the research they Hexham Northumberland in the use of proteomics for drug discovery, need. NEPAF’s goal is to support companies 3NS POSTCODE: development andNE46 manufacture and in the carrying out significant and, in some cases, diagnosis WEB: and monitoring of disease. ground-breaking research and development www.epitope-informatics.com usingePitope proteomics that willissecure the bioinformatics company providing services for Informatics an applied Glenn Majorof services epitope discovery.

A particular focustois epitope prediction for the identification CONTACT: The facility provides a range reputation of the North East as the place and targeting of antibody epitopes. Global operation with biopharmaceutical

JOB ROLE: Managing Director / Head of including protein Applied extraction, using one of the do biotech business.”

Bioinformatics companies, research institutes and universities, ePitope Informatics works in first pressure cycling homogenisers in the UK, Achimareas Treumann, scientific manager of that include vaccine production, biotherapeutic design and antibody production foraim diagnostics science research.

EMAIL: enquiries@epitope-informatics.com protein separation using 2-D Polyacrylamide NEPAF says: “Our at NEPAFand is tolifeuse

Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions TEL: 01434 609962 multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and commercial Harlow Printingresearch.

Ltd The level different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable

ADDRESS: Maxwell Street capabilities for biomarker discovery, signal results and our scientists’ communication South Shields transduction pathway analysis, skills ensure that you will understand them. ” Tyne and Wearprotein NE33protein 4PU identification, POSTCODE: expression analysis, quantification and characterisation.

For further information visit: WEB: www.harlowprinting.co.uk www.nepaf.com John Short Harlow Printing Ltd is a major manufacturer and supplier of specialist products to With CONTACT: its main laboratory located on the Marketing Director both the public and private sectors. campus JOBof ROLE: Newcastle University and a second laboratory located on the campus of Accredited to both ISO 9001/2000 and 14001, any products purchased from our EMAIL: johnshort@harlowprinting.co.uk company are manufactured to exacting quality and environmental standards.

Durham University, NEPAF is supported by 0191 4554286 the regionalTEL: development agency One North Harlow Printing Ltd created the Health for All Children website to provide support East and the European Regional Development for the publication of the same name.

Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 1 7

A B

P R O T E O M I C S FIntraHealth U T ULtdR E OF BIOTECHNOLOGY

C D E F

ADDRESS: 1st Floor William Brown Centre Manor Way Peterlee County Durham POSTCODE: SR8 5TW WEB: www.intrahealth.ltd.uk

CONTACT: Greg Moorhouse JOB ROLE: Managing Director EMAIL: greg.moorhouse@intrahealth.co.uk

IntraHealth is a well-established innovative company working exclusively in the NHS primary care environment. We contract with a range of NHS bodies including Primary Care Trusts (PCTs), Personal Medical Services (PMS) and General Medical Services (GMS) GP practices. Through these contracts we have gained unique and extensive experience of delivering high quality services through the management and support of GPs and medical partnerships.

TEL: 0191 5181564 FAX: 0191 5181656

G Nonlinear Dynamics Ltd

H I

J

WEB: www.nonlinear.com

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: Keel House Garth Heads Newcastle Upon Tyne POSTCODE: NE1 2JE

CONTACT: Will Dracup JOB ROLE: CEO EMAIL: info@nonlinear.com TEL: 0191 2302121 FAX: 0191 2302131

Nonlinear Dynamics’ product range includes analysis software for 2D electrophoresis gels, label-free LC-MS, MALDI and SELDI data as well as tools for multivariate statistical analysis. Our unique analysis approach has transformed proteomics research – it provides faster more accurate quantitation, robust statistical analysis and has enabled cross-lab reproducibility.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteinsEast in a fitPublic healthy cell from those in a What is more, since proteomics can North Health Observatory diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural

ADDRESS: Wolfson Research Insititute a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Durham University Queen’s from all other proteins in Campus the cell or organism they could help diagnose the disease much crops and more efficient biofuels, and in University Boulevard and studied in great detail.

Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to Stockton-on-Tees approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity.

Tees Valley some important information. do not the cause of the disease, in which case they TS17 Proteins 6BH POSTCODE: The North East Public Observatory main of tasks exist in isolation from each other, so although could act as targets against whichHealth new drugs Of (NEPHO) course much thisinclude: was promised from www.nepho.org.uk WEB: removes studying pure proteins interference can be developed. the earliest days of proteomics, and it has • Monitoring health and disease trends and highlighting areas for action; from other proteins it alsoSusan reduces a lot of the Panrucker • Identifying gaps in health informationto be said the results so far have not lived CONTACT: • Advising on methods for health equityup audits and health impact assessments

JOBinteraction ROLE: Business complexity and whichManager is actually a to expectations.

This is in part because • Drawing together information from different sources in new ways to improve key part of how proteins work. the technology has had to catch up with health TEL: 0191 3340398 the theory.

Some of the equipment used for • Carrying out projects to highlight particular health issues.

FAX: 0191 3340391 Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately PowerTrial Ltd ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: The Windmill to map out all the proteins in any given cell or handle the immensely large and complex data Claremont Road Newcastle Tyne organism, at a given time.

Once youupon can do generated by this research has also increased 4AL POSTCODE: this it enables you to trulyNE2 understand how the exponentially over the decade, and finally, but chemical building WEB: blockswww.powertrial.com of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect Stephen PowerTrial produce web software for clinical research. The In a way, theCONTACT: genome is rather likeO’Brien a dictionary new techniques andcompany’s methods toflagship allow them product, Symphony, allows you to build, deploy and analyse electronic case

JOB ROLE: Chief Executive Officer which contains a list of all the possible words to generate and interpret robust reliable data. report forms for any form of clinical trial or registry activity and to manage in a language, whereas proteome is more s.g.obrien@powertrial.com regulatory approvals and documentation.

EMAIL: the individual books in that language, like the Since different cell types can be characterised In many ways proteomics has finally caught TEL: 0191 4973363 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

1 1 8 C E L S H E A LT H C O N N E C T

changing as it ages and even in response to changes from outside and within.

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

SCHIN Ltd

B

ADDRESS: First Floor, Bede House All Saints Business Centre Newcastle upon Tyne POSTCODE: NE1 2ES

C

WEB: www.schin.co.uk

CONTACT: Ian Purves JOB ROLE: CEO EMAIL: marketing@schin.co.uk TEL: 0191 2436100 0191 2436101

For fifteen years SCHIN has been recognised, within the NHS and internationally, as a leading centre for health informatics. SCHIN’s product portfolio includes CKS, a world-leading evidence-based online knowledge service, and the NHS Appraisal Toolkit, used by close to 40,000 UK doctors to simplify and enhance their appraisal procedure. SCHIN also offers comprehensive, proactive drug ontology and medication review products, alongside screening/surveillance, document management and radiology/digital imaging services.

D E F G

UK Haptics Ltd

WEB: www.ukhaptics.co.uk

H

ADDRESS: Albert House Rothbury Morpeth Northumberland POSTCODE: NE65 7SR

CONTACT: Gary Todd JOB ROLE: Managing Director EMAIL: gary@ukhaptics.co.uk

NEPAF (the TEL: North01669 East 621905 Proteome Analysis FAX: 01669 620454 Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

The facility will give clients access to expertise in the use of proteomics for drug discovery, development and manufacture and in the diagnosis and monitoring of disease.

The facility provides a range of services including protein extraction, using one of the first pressure cycling homogenisers in the UK, protein separation using 2-D Polyacrylamide Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide capabilities for biomarker discovery, signal transduction pathway analysis, protein expression analysis, protein identification, quantification and characterisation.

With its main laboratory located on the campus of Newcastle University and a second laboratory located on the campus of Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

I J UK Haptics Ltd - Medical training software you can touch UK Haptics develop virtual reality training solutions; using haptic technology and high quality photo-realistic 3D graphics to create interactive virtual environments where students learn and develop essential clinical skills.

Virtual Veins, theirhas first a training simulator, provides risk-free unlimited scenarios, Through Cels, NEPAF dedicated real-time metrics, cost savings and performance feedback, enabling students to team practise of six scientists, including experienced their venepuncture skills until confident and competent. practitioners in the field of proteomics.

Dr Glen Kemp , project manager, NEPAF says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development using proteomics that will secure the reputation of the North East as the place to do biotech business.”

Achim Treumann, scientific manager of NEPAF says: “Our aim at NEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic and commercial research. The level of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 1 9

be well, connected

Driving the business of life sciences

H E A LT H & S O C I A L C A R E

A B

P R O T E O M I C S F Chase U T Park URE OF BIOTECHNOLOGY

C D E

ADDRESS: 8 Millfield Road Whickham Newcastle upon Tyne POSTCODE: NE16 4QA

WEB: www.whickhamvilla.co.uk

F

CONTACT: Alistair McDonald JOB ROLE: Service Development Manager EMAIL: alistairmcdonald@ whickhamvilla.co.uk

Chase Park is a specialist provider of rehabilitation. Aiming to empower people with disabilities to fulfil their potential by providing high quality, physical and social rehabilitation with holistic care to promote independence. Our national award winning health club has been designed specifically as a truly accessible space for people of all ages and abilities within an extremely high quality and relaxing inclusive environment.

TEL: 0191 488 7351 FAX: 0191 488 7351

G Connect for Care

H I J K L M N O P Q R S T U V W X Y Z

ADDRESS: 15 Featherstone Grove Newcastle POSTCODE: NE3 5RF WEB: www.connectforcare.com CONTACT: Dr Sanjeet Pakrasi JOB ROLE: Managing Director EMAIL: info@connectforcare.com TEL: 0191 2362475 FAX: 0191 6409216

Connect for Care is an innovative healthcare company using technology and a specialist service to make a difference: • A novel service for care and communication with vulnerable individuals supported by a professional.

• For people who are socially isolated or have memory or cognitive problems and/or need telecare

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteins in a Physical fit healthy cell Health from thoseCentres in a What is more, since proteomics can Connect Ltd diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural

ADDRESS: 36 Apex Business Village a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Northumberland Business Park. from all other proteins in Cramlington the cell or organism they could help diagnose the disease much crops and more efficient biofuels, and in Northumberland and studied in great detail.

Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to POSTCODE: NE23 7BF approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity. some important information.

Proteins do not the cause of the disease, in which case they WEB: www.connectphc.co.uk Connect Physical Health are the largest privately owned exist in isolation from each other, so although could act as targets against which newLtd drugs Of course much of thisphysiotherapy was promised from Andrew Walton provider in the UK and for over 15 years have provided care to more NHS patients studying pureCONTACT: proteins removes interference can be developed. the earliest days of proteomics, and it has than any other independent provider. Our range of services have developed to

JOB ROLE: Managing Director from other proteins it also reduces a lot of the to be said theclients resultsinso farphysiotherapy have not lived reflect the changing needs and expectations of our our or complementary therapy clinics, NHSup contracts and UK occupational EMAIL: andrew.walton@connectphc. complexity and interaction which is actually a to expectations.

This is in part because physiotherapy contracts. of how proteins co.uk key part work. the technology has had to catch up with TEL: the theory. Some of the equipment used for 0191 2504991 Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Counted4 CIC ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide amount of computing power required to 4 Mary Street a means

ADDRESS: Sunderland to map out all the proteins in any given cell or handle the immensely large and complex data SR1 3NH you can do organism, atPOSTCODE: a given time.

Once generated by this research has also increased this it enables youWEB: to trulywww.counted4.co.uk understand how the exponentially over the decade, and finally, but chemical building blocks of life truly interact. perhaps most importantly, the people working CONTACT: Ashley O’Connor in the field have had to develop and perfect

JOB ROLE: Office Manager A modern progressive Community Interest to develop a full In a way, the genome is rather like a dictionary newCompany, techniquesfounded and methods to allow them range of treatment options for people who misuse substances providing services which contains a listTEL: of all0845 the 6034395 possible words to generate and interpret robust reliable data. for the NHS, Safer Partnerships, private industry, and the voluntary sector. C4 CIC 0191 5645701 is more FAX: the in a language, whereas proteome is led by an integrated team drawn from health, social care and the third sector. like the individual books in that language, Since different cell types can be characterised In many ways proteomics has finally caught these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

1 2 2 C E L S H E A LT H C O N N E C T

changing as it ages and even in response to changes from outside and within.

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Dementia Care Partnership (DCP)

WEB: www.dementiacare.org.uk

B

ADDRESS: The Bradbury Centre Darrell Street Brunswick Village Newcastle upon Tyne Tyne and Wear POSTCODE: NE13 7DA

CONTACT: Kay Murray JOB ROLE: Training Manager

C Dementia Care Partnership (DCP) is a registered Newcastle based charity which provides local services for people with dementia of all ages, older people including people from the black and minority ethnic communities with functional mental illness (depression, anxiety states, etc), as well as the carers.

EMAIL: admin@demetiacare.org.uk

D E F

TEL: 0191 2171323

G Eden Cottage Care Home

H

ADDRESS: 37 Cobden Street Darlington County Durham POSTCODE: DL1 4JF CONTACT: Maureen Horton JOB ROLE: Proprietor EMAIL: mhorton@assurebroadband. co.uk TEL: 01325 281061

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: Suite 119 Tedco House The facility will give clients access to expertise Jarrow Tyne andfor Wear in the use of proteomics drug discovery, 3DT POSTCODE: development andNE32 manufacture and in the

diagnosis WEB: and monitoring of disease. www.healthclubtv.com Chris CONTACT: The facility provides a Cooke range of services JOB ROLE: Director including protein extraction, using one of the first pressure cycling homogenisers in the UK, info@healthclubtv.com EMAIL: protein separation using 2-D Polyacrylamide TEL: 0845 0559120 Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein system. The These instruments Wearside Health provide & arraying ADDRESS: capabilities for biomarker signal Racquetsdiscovery, Club 3 Camberwell transduction pathway analysis,Way protein Doxford International Business expression analysis, protein identification, Park quantification andSunderland characterisation.

POSTCODE: SR3 3XN

With its main laboratory located on the WEB: www.mysportsclinic.com campus of Newcastle University and a Damon Voss CONTACT: second laboratory located on the campus of Durham JOBUniversity, ROLE: Owner NEPAF is supported by the regional development agency One North mail@mysportsclinic.com EMAIL: East and the European Regional Development 0191 5200066 TEL:Cels Fund. In 2007 secured £4 million to FAX: 0560 1534536 develop the facility, which is the only one of its kind in the North East of England.

I J Eden Cottage Care Home provide the following facilities and services: Long Stay Care • Day Care • Respite Care • Own GP if required • Own Furniture if required • Pets by arrangement • Smoking not permitted • Close to Local shops • Near Public Transport • Minibus or other transport • Wheelchair access • Ground Floor Accommodation only • Gardens for residents • Phone Point in own room/Mobile • Television point in own room • Residents Internet Access

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

K L M

Dr Glen Kemp , project manager, NEPAF Healthclubtv says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development usingHealthclubtv proteomics that will secure the film clips that you can watch online, download produces exercise directof tothe your pc, mobile or ipod. reputation North East asphone the place to Healthclubtv offers free online personal training advice and programming, nutritional analysis and reports to allow you to do biotech business.” get a healthy balanced diet. A full corporate wellness programme is in operation AchimtoTreumann, scientific manager of reduce absenteeism and increase employee productivity in the work place.

NEPAF says: “Our aim at NEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic commercial research. The level Myand Sports Clinic of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com My Sports Clinic is fast becoming a leading force in sports physiotherapy and rehabilitation. Our winning formula of ‘hands-on’ and ‘active’, exercise based client management means that we are able to assist you in any situation, from recurring injuries to general care and maintenance.

Our main goal is to prevent injury in the first instance and enhance your performance levels in the shortest time possible.

N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 2 3

A B

P R O T E O M I C SNeural FU T U(UK) R Ltd E Pathways OF BIOTECHNOLOGY

C D E F

ADDRESS: Design Works William Street Felling Gateshead POSTCODE: NE10 0JP

WEB: www.neural-pathways.co.uk

CONTACT: Vicki Gilman JOB ROLE: Managing Director EMAIL: info@neural-pathways.co.uk

A specialist therapy provider for people of all ages with neurodisabilities. We offer community rehabilitation with a service working into the individual’s home, workplace, care home, school or other appropriate environment. We fill the gaps when other providers including the NHS are involved. We also provide to residential and nursing care homes, training organisations and charities.

TEL: 0191 423 6240 FAX: 0191 423 6240

G OmniRead Group Limted

H I

J

WEB: www.omnireadgroup.com

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: Rotterdam House 116 Quayside Newcastle upon Tyne POSTCODE: NE1 3DY

CONTACT: Mark Kelk JOB ROLE: Managing Director EMAIL: mark@omnireadgroup.com TEL: 0191 2064128

OmniRead Group Limited is a company focused on improving people’s reading ability off any electronic display, for example a computer screen or a mobile phone.

We have developed and patented a near objective method of identifying the user’s unique screen settings to improve their reading performance and increase

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteins in aMedical fit healthy cellPhysics from those Department in a What is more, since proteomics can Regional diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural

ADDRESS: Freeman Hospital a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Newcastle upon Tyne from all other proteins in NE7 the cell they could help diagnose the disease much crops and more efficient biofuels, and in 7DNor organism POSTCODE: and studied in great detail. Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to WEB: www.rmpd.org.uk approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity. some important information.

Proteins do not the cause of the which case they Prof Alan Murray CONTACT: The disease, Regionalin Medical Physics Department is part of the UK’s National Health Clinical JOBfrom ROLE: exist in isolation each other,Director so although could act as targets which anew drugs Of course much of this wasand promised from Service against and provides wide range of clinical, scientific, technical community services throughout northern a population of over three studying pure proteins removes interference can be developed. theEngland earliest to days of proteomics, and it has EMAIL: alan.murray@ncl.ac.uk million people. The Department, which is a Clinical Directorate of the Newcastle from other proteins it also reduces a lot of the to be said the results so far have not lived

upon Tyne Hospitals NHS Foundation Trust, provides a first class medical physics 2336161 ext 26808 TEL: 0191 complexity and interaction which is actually a to expectations.

This is inand part because service that adds value to health care up through regional integration innovation. key part of how proteins work. the technology has had to catch up with the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately SJB Associates ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: 12 Troon Avenue to map out all the proteins in any given cell or handle the immensely large and complex data Darlington County organism, at a given time.

Once Durham you can do generated by this research has also increased 3HY POSTCODE: this it enables you to trulyDl1 understand how the exponentially over the decade, and finally, but chemical building WEB: blockswww.sjbassociates.org.uk of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect Samantha SJB Associates is a caring, compassionate new and company withto25allow yearsthem In a way, theCONTACT: genome is rather like aBrittle dictionary newintuitive techniques methods previous experience in the care sector. It is driven by a passion for enhancing

JOB ROLE: Managing Director which contains a list of all the possible words to generate and interpret robust reliable data. and enriching lives of people with dementia by transforming their environment in a language, whereas proteome is more info@sjbassociates.org.uk with tactile, sensory and reminiscence materials. They are committed to making EMAIL: the difference. individual books in that language, like the Since differenta cell types can be characterised In many ways proteomics has finally caught TEL: 01325 464562 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no FAX: 01325 464562 needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

1 2 4 C E L S H E A LT H C O N N E C T

changing as itreading ages and even in response to comfort. changes from outside and within.

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Sue Clark Health & Fitness

B

ADDRESS: 8 Moorfield Newcastle POSTCODE: NE2 3NL

C

WEB: www.sueclarkhealthandfitness. co.uk CONTACT: Sue Clark

EMAIL: info@sueclarkhealthandfitness. co.uk TEL: 07780 591 652

Sue Clark Health & Fitness is based in Jesmond, Newcastle upon Tyne and was established in 2004. The company aims to offer personal and corporate clients a range of services which help deliver optimum health and wellbeing to improve quality of life.

Whether clients are looking to improve existing fitness levels, lose weight, improve body shape, correct postural imbalances, reduce stress related illness, I like to look holistically at their whole lifestyle and how it impacts on their overall wellbeing.

D E F G

The Outdoor Fitness Company

H

ADDRESS: 3 Rectory Cottage Old Ryton Village Tyne and Wear POSTCODE: NE40 3QA

I J

WEB: www.getfitoutside.co.uk

CONTACT: Gary Nash JOB ROLE: Owner EMAIL: info@getfitoutside.co.uk TEL: 07900 918938

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: 2 Whitby Avenue Hexham ThePOSTCODE: facility will give clients NE46 3JJ access to expertise

in the use of proteomics for drug discovery, WEB: development andwww.nikkenwellbeing.co.uk/ manufacture and in the info/visionforchange diagnosis and monitoring of disease.

CONTACT: Solveiga Liegis-Johnston Director The facility JOB ROLE: provides a range of services

includingEMAIL: protein solveiga@visionforchange.co.uk extraction, using one of the first pressure cycling homogenisers in the UK, 603966 TEL: 01434 protein separation using 2-D Polyacrylamide FAX: 01434 603966 Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide capabilities for biomarker discovery, signal transduction pathway analysis, protein expression analysis, protein identification, quantification and characterisation.

With its main laboratory located on the campus of Newcastle University and a second laboratory located on the campus of Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

Newcastle’s Premier Bootcamp Company. Exercise whilst exploring some of the North East’s best kept secrets.

Fitness sessions run from Monday to Saturday with often more than one class to choose from per day.

We Cels, provide Slimming Boot Camp For All and Cardio Club all with a money Through NEPAF has Club, a dedicated back guarantee. team of six scientists, including experienced practitioners in the field of proteomics.

Dr Glen Kemp ,For project manager, NEPAF Vision Change says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development Vision for change are independent wellness consultants and distributors for usingNikken proteomics that will secure the Wellnes products/technologies.

Focus is on prevention and self care. reputation of the North East as the place to Our “wellness” home creates the optimum environment for good health. We offer do biotech business.” unique patented products for bone density/health and menopause.

Achim Treumann, scientific manager of NEPAF says: “Our aim at NEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic and commercial research. The level of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 2 5

CVcd8ZcigVa PhjXXZhh i]gdj\] cVcdbViZg^VahR

CVcd8ZcigVa ^h Vc Vaa^VcXZ d[ aZVY^c\ dg\Vc^hVi^dch XgZViZY id jcadX` i]Z kVhi XdbbZgX^Va VcY hdX^ZiVa ediZci^Va d[ cVcdbViZg^Vah# CVcd8ZcigVa ]Zaeh [dg\Z ^cYjhign l^YZ XdaaVWdgVi^dch VXgdhh bVg`Zih VcY hjeean X]V^ch0 VcY egdk^YZh VXXZhh id `Zn ZcVWa^c\ iZX]cdad\^Zh! [VX^a^i^Zh VcY ZmeZgi^hZ#

NanoCentral’s providers include: Nanomaterial Synthesis • Johnson Matthey • Intrinsiq Materials Ltd • Promethean Particles • nanoLake • Innovnano • Harman Technology Limited • Nanogap Dispersion & Formulation • University of Liverpool • Netzsch Mastermix Ltd • Maelstrom APT Ltd • Buhler Limited • Lubrizol Advanced Materials • Imerys Minerals Ltd • Hosokawa Micron Ltd • Primary Dispersions Ltd Applications Development • The Electrospinning Company • Teknek Ltd • Printed Electronics Ltd • Nanoforce • Macdermid Autotype • Ilika Technologies Ltd • The Wolfson Centre Characterisation • Intertek MSG • CEMMNT Nanomaterial SHE • Safenano • AssuredNano

As a not-for-profit organisation, NanoCentral can offer significant benefits to organisations which may currently be put off by perceived high cost, risk or lack of knowledge of using nanomaterials. As world-class experts in nanomaterials technology, we can help you to overcome problems that you are already facing, or assist you to develop innovative bespoke solutions.

Backed by the Technology Strategy Board, the Regional Development Agency, One NorthEast, and the Centre for Process Innovation, NanoCentral is based in the traditional heart of the science and chemical sector on Teesside at the Wilton Centre.

NanoCentral was set up to help industry gain from the revolution that’s taking place in nanomaterials. It is about creating jobs and profits for companies and thereby increasing the UK gross domestic product.

Why use NanoCentral?

NanoCentral can provide you access to technologies and expertise from our extensive Alliance of Providers to help you find solutions to the issues you have identified. If you require a new technology to solve your problem, NanoCentral can introduce you to potential partners to add expertise and capability to the development process.

This part of the process is completely free of charge.

At NanoCentral you can get help from a team of people with an unmatched combination of industrial, technological and business expertise.

A major part of NanoCentral’s mission is also to ensure the safe use of nanomaterials both in their development and for end users. NanoCentral is in partnership with the SAFENANO initiative at the Institute of Occupational Medicine to incorporate health, safety and environmental expertise. NanoCentral has also instigated AssuredNano® which is the first nanomaterials Safety, Health & Environment (SHE) Accreditation Scheme featuring annual Compliance Auditing.

To assist nanotechnology practitioners in all market areas, NanoCentral is instituting a Resource Guide to Nanotechnology and Nanomaterials Services.

Called NanoPerspective, the resource guide is the prime listing publication for all organisations within the global nanotechnology supply chain, ranging from research through product development to manufacture and supply, plus ancillary services such as legal, IP consultancy and business finance. It will be a who’s who of the nanotechnology sector.

Due for publication in May, if you want to ensure your organisation is listed in the publication, or to just ensure you get a copy of this inavluable Resource Guide on its publication, please contact a member of the team below.

If you are interested in joining the nanomaterials revolution or would like to know how NanoCentral can help you as a technology provider or user, get in touch with the team: NanoCentral at the Centre for Process Innovation, Wilton Centre, Wilton, Redcar, TS10 4RF E: steve.devine@nanocentral.eu T: 01740 625 729

www.nanocentral.eu 1 2 6 C E L S H E A LT H C O N N E C T

NanoCentral continually captures emerging technologies from a wide range of sectors and makes these available to you. A key advantage we offer is access to facilities to create and test these nanomaterial solutions in a cost-effective way.

be well, connected

Driving the business of life sciences

MEDICAL DEVICES

A B

PROTEOMICS FU TU Analox Ltd R E OF BIOTECHNOLOGY

C D E F

ADDRESS: Analox Sensor Technology 15 Ellerbeck Court Stokesley Business Park North Yorkshire POSTCODE: TS9 5PT WEB: www.analox.net

Analox’s vision is to be the first choice for gas sensing in hostile environments.

We specialise in the design and manufacture of gas monitoring equipment for a diverse range of international customers - the common element being the application. Analox products are being used to either protect or sustain life.

CONTACT: Michelle Morley JOB ROLE: Marketing Manager EMAIL: info@analox.net TEL: 01642 711400 FAX: 01642 713900

G Carina VT Ltd

H I

J K L M N O P Q R S T U V W X Y Z

ADDRESS: Lancaster House 29A Harmire Enterprise Park Barnard Castle County Durham POSTCODE: DL12 8XT WEB: www.carinavt.com

CONTACT: Kath Johnson EMAIL: kjohnson@carinavt.com

Carina VT Limited is the distribution and customer support company for the VIASYS Pulmonetic Systems LTV series of ventilators in the United Kingdom.

Responsible for one of the world’s leading portable ventilator technologies, it is dedicated to providing the highest level of service, after sales support and customer care, and anticipating the future needs of ventilator users.

TEL: 07739 678 173

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit healthy cell from CDx Ltdthose in a diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: Stanfield Business Centre a small number of proteins are separated out be a symptom of the disease, in which case Sunderland from all other proteins in Tyne the cell orWear organism they could help diagnose the disease much and SR2Although 8BL and studiedPOSTCODE: in great detail. this earlier, and thus improve the prognosis for approach remains very valuable it misses out the patient, or the different proteins may be WEB: www.cdx.uk.com some important information. Proteins do not the cause of the disease, in which case they Bill other, Cunningham CDx Ltdagainst is a specialist management company CONTACT: exist in isolation from each so although could act as targets which diagnostics new drugs and healthcare Of course much of this was promised from Managing Director offering a wide range of novel rapid tests and small instruments to be used in pureJOB ROLE: removes studying proteins interference can be developed. the earliest days of proteomics, and it has hospital clinics, pharmacies and health centres. from other proteins it alsobcdx@aol.com reduces a lot of the to be said the results so far have not lived EMAIL: The main focus of the company centres all aspects of theisdiagnosis and

complexity and interaction which is actually a upround to expectations.

This in part because management of diabetes and diabetes-related disease.

TEL: 0191 key part of how proteins work.5642036 the technology has had to catch up with FAX: 0191 5642037 the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Chemviron Carbon Cloth Division ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Rainton Bridge Industrial Estate to map out all the proteins in any given cell or handle the immensely large and complex data Houghton le Spring Tyne and Wear organism, at a given time.

Once you can do generated by this research has also increased 5PP POSTCODE: this it enables you to trulyDH4 understand how the exponentially over the decade, and finally, but chemical building WEB: blockswww.chemvironcarbon.com of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect Bob Brown Chemviron Carbon’s Cloth Division, produces Activatedand Carbon Clothtofor a them In a way, theCONTACT: genome is rather like a dictionary new techniques methods allow range of special applications.

JOB ROLE: General Manager which contains a list of all the possible words to generate and interpret robust reliable data. in a language, whereas proteome is more mcollins@calgoncarbon-eu.com ZORFLEX® is supplied in several forms and can be custom slit, cut and laminated EMAIL: the specific Currently it is supplied the Ostomy, Wound dressings, individual books in that language, like the Since differentforcell types applications. can be characterised In many into ways proteomics has finally caught Respiratory mask and medical devices markets.

TEL: 0191 5846962 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 2 8 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Christison Particle Technologies Ltd

B

ADDRESS: Albany Road Gateshead Tyne and Wear POSTCODE: NE8 3AT

C

WEB: www.christison.com www.it-evolve.com

D

CONTACT: Mary Gourley

EMAIL: sales@christison.com TEL: 0191 4788120 FAX: 0191 4900549

Christison Particle Technologies markets and supports advanced analytical instrumentation for the characterisation of a wide variety of materials in the pharmaceutical, healthcare and biotechnology industry. We provide advanced particle size measurement equipment, particle size reduction equipment and sample preparation equipment

E F G

Electrochemical Sensor Techology (EST) Ltd

H

ADDRESS: The Old Brewery Castle Eden Hartlepool POSTCODE: TS27 4SU

I J

WEB: www.electrosensortech.co.uk

CONTACT: Dr Neil Marshall JOB ROLE: Director EMAIL: info@electrosensortech.co.uk TEL: 01429 835455

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: 3 Startforth Road Riverside Park The facility will give clients access to expertise Middlesbrough Cleveland in the use of proteomics for drug discovery, 1PJ POSTCODE: development andTS2 manufacture and in the

diagnosis WEB: and monitoring of disease. www.femeda.com Jim a Bradley CONTACT: The facility provides range of services JOB ROLE: Chairman including protein extraction, using one of the first pressure cycling homogenisers in the UK, jim.bradley1@btinternet.com EMAIL: protein separation using 2-D Polyacrylamide TEL: 01642 808 888 Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide

ADDRESS: 2 Rivergreen Business Centre capabilities for biomarker discovery, signal Queens Meadow transduction pathway analysis, protein Hartlepool TS25protein 2DL POSTCODE: expression analysis, identification, quantification and characterisation.

WEB: www.hartbio.com

Albert Pattison With CONTACT: its main laboratory located on the Managing Director campus JOBof ROLE: Newcastle University and a second laboratory located on the campus of EMAIL: info@hartbio.com Durham University, NEPAF is supported by 01429 271100 the regionalTEL: development agency One North FAX: 01429 277085 East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

EST provides expertise in the research and manufacture of sensors.

We have developed a portable meter for the measurement of ammonia in liquids. The meter provides for low cost measurements. The meter may be used in medical applications where ammonia cannot be converted to urea, and excreted normally.’

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

K L M

Dr Glen Kemp , project Ltd manager, NEPAF Femeda says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development usingFemeda proteomics that willbased secure the Ltd is a UK company focused on development of medical devices to treat incontinence.

The company is developing revolutionary devices reputation of the North East as the place to for electro stimulation of the pelvic floor. In conjunction with pelvic floor muscle do biotech business.” exercises Achim Treumann, scientific manager of Femeda is also developing probes for use by continence practitioners NEPAF says: “Our aim at NEPAFvaginal is to use that will be more convenient, comfortable and hygienic than current leading edge technology to provide solutions alternatives. for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic commercial research.

Hartand Biologicals Ltd The level of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com Hart Biologicals’ company strategy is to develop diagnostic assays and undertake contract manufacturing within particular, well-defined sectors where the experience of its management team can be maximised to bring added value to orders and contracts by offering more than simply a manufacture and supply facility. The field of blood coagulation, haemostasis and platelet function analysis.

N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 2 9

A B

P R O T E O M I C S HBFInnovations U T U(HBI) RE OF BIOTECHNOLOGY

C D

ADDRESS: 1st Floor William Leech Building Faculty of Medical Sciences Newcastle University Newcastle upon Tyne Tyne and Wear POSTCODE: NE2 4HH WEB: www.hbinnovations.co.uk

E

EMAIL: hbi@ hbinnovations.co.uk

HBI is a contract research and development company providing development of in-vitro diagnostic reagents and assays for IVD companies on a global basis.

The company currently has 5 scientists from a variety of backgrounds in the life sciences with experience in a wide degree of development techniques.

F G Huntleigh Healthcare Ltd

H I

J

WEB: www.huntleigh-healthcare.com

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: Unit 11b Brooklands Way Boldon Business Park Boldon Tyne and Wear POSTCODE: NE35 9LZ

CONTACT: John McEwen JOB ROLE: Regional Business Manager EMAIL: john.mcewen@huntleighhealthcare.com

The term Proteomics was only coined TEL: 0778 0955170 around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

As part of the Huntleigh Technology PLC Group, Huntleigh Healthcare and Huntleigh Diagnostics manufacture an extensive range of non-invasive healthcare products and instrumentation for medical applications.

Huntleigh Nurse Advisors, Product Specialists and Technical Service teams work from 15 Service Centres providing expert advice, clinical education and training support programmes, management information packages and a nationwide changing as ittechnical ages andservice even inprogramme, response towhich always to giveputs us important insights in the ageing the patient first.

process as a whole. So there are scientific questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteins in a fit healthy cellSystems from those inHoldings a What is more, since proteomics can Immunodiagnostic plc diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural

ADDRESS: 10 Didcot Way a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Boldon Business Park from all other proteins in Boldon the cell or organism they could help diagnose the disease much crops and more efficient biofuels, and in Tyne and Wear and studied in great detail.

Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to POSTCODE: NE35 9PD approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity. some important information.

Proteins do not the cause of the disease, in which case they WEB: www.idsplc.com Immunodiagnostic Systems (IDS) is dedicated to the development provision exist in isolation from each other, so although could act as targets against which new drugs Of course much of this was and promised from Roger Duggan of immunoassays for use in clinical/research laboratories. studying pureCONTACT: proteins removes interference can be developed. the earliest days of proteomics, and it has

JOB ROLE: Managing Director from other proteins it also reduces a lot of the to be saidprovision the results so far have not The company enjoys a dominant position in the of immunoassay kitslived for the determination of Vitamin D. We areup determined to remain forefront of EMAIL: rtd@idsltd.com complexity and interaction which is actually a to expectations.

Thisatisthe in part because Vitamin D testing, and the appearancethe of technology automated has Vitamin the up IDS-iSYS of how proteins work. key part had D toon catch with underlines this determination.

TEL: 0191 5196109 the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic Leica Biosystems Newcastle Ltdto discover more proteins, more accurately ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Balliol Business Park West to map out all the proteins in any given cell or handle the immensely large and complex data Newcastle upon Tyne NE12 8AW organism, atPOSTCODE: a given time.

Once you can do generated by this research has also increased this it enables you to truly understand how the exponentially over the decade, and finally, but WEB: www.leica-microsystems.com chemical building blocks of life truly interact. perhaps most importantly, the people working the fieldand have had to develop and perfect CONTACT: Ian Milton Leica Microsystems is a leading global in designer producer of innovative highPA Fiona

ROLE:is rather In a way, theJOB genome likeHarrison a dictionary new techniques and methods to allow them tech precision optics systems for the analysis of microstructures. which contains a listTEL: of all0191 the 215 possible words to generate and interpret robust reliable data.

4242 It is one of the market leaders in each of the fields of Microscopy, Confocal Laser in a language, whereas the proteome is more Scanning Microscopy, Microscope Software, Specimen Preparation and Medical like the individual books in that language, Since differentEquipment. cell types can be characterised In a many ways proteomics hasfor finally caught The company manufactures broad range of products numerous applications requiring microscopic imaging, measurement analysis.

It also these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is and not to say there are no offers system solutions in the areas of Life Science including biotechnology and needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are medicine, as well as the science of raw materials and industrial quality assurance. those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 3 0 C E L S H E A LT H C O N N E C T

changes from outside and within.

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Parker Domnick Hunter

WEB: www.domnickhunter.com

B

ADDRESS: Parker Domnick Hunter Process Division Durham Road Birtley Co. Durham POSTCODE: DH3 2SF

CONTACT: David Ridealgh JOB ROLE: Product Manager, Pharmaceutical EMAIL: david.ridealgh@parker.com TEL: 0191 4105121

C Parker domnick hunter, process filtration is focussed on adding value to your business through innovative filtration solutions. The company manufactures a range of filters for the clarification, stabilisation & sterilisation of liquids and gases primarily for bulk pharmaceutical chemicals / API, bulk fermentation, aseptic final fill and biopharmaceutical production. A fully scaleable filter range includes single use disposable products

D E F G

Peacocks Medical Group

WEB: www.peacocks.net

H

ADDRESS: Benfield Business Park Benfield Road Newcastle upon Tyne Tyne and Wear POSTCODE: NE6 4NQ

CONTACT: Liz Holden JOB ROLE: PA to Management Team EMAIL: info@peacocks.net

I J Peacocks Medical Group manufactures and supplies medical equipment and services throughout the UK. The group comprises of three separate trading companies: • Peacocks Orthotics - Delivers a provision of stock and custom manufactured orthoses.

• Peacocks Direct Sales - Retail and wholesale distribution and sales of healthcares andhas mobility products.

Through Cels, NEPAF a dedicated • Peacocks Surgical & Medical Equipment - Supplying, installing and servicing team ofwasher six scientists, including experienced disinfectors, sterilisers, theatre tables and lights.

NEPAF (the TEL: North0191 East2769600 Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and will provide Dr Glen Kemp , project manager, NEPAF Premier Healthcare & Hygiene Ltd them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art ADDRESS: Unit 5 facilities that allow even the smallest of Lloyd Court The facility will give clients access to expertise companies to carry out the research they St Omers Road in the use of proteomics for drug discovery, need. NEPAF’s goal is to support companies Gateshead and Wearand in the development andTyne manufacture carrying out significant and, in some cases, POSTCODE: NE11 9EP diagnosis and monitoring of disease. ground-breaking research and development using Premier proteomics that will&secure theLtd is a multi discipline supplier of healthcare www.premierhh.co.uk Healthcare Hygiene WEB: and hygiene products.

Wethe areplace a supplier The facility provides a range of services reputation of the North East as to to local government, NHS, chiropody and medical practices, nursing and residential homes, industry and the general CONTACT: John Wilson including protein extraction, using one of the do biotech business.” public.

JOB ROLE: Managing Director first pressure cycling homogenisers in the UK, Achim Treumann, scientific manager of Where can is offer COSHH training, health & safety information EMAIL: john@premierhh.co.uk protein separation using 2-D Polyacrylamide NEPAF says:appropriate, “Our aim at we NEPAF to use and expert advice to your requirements.

Gel Electrophoresis (2D-PAGE) and leading edge technology tosolve provide solutions TEL: 0191 4611788 multi-dimensional liquid chromatography for real world biochemical problems. Our 4611798 FAX: 0191 (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and commercial research. The level Rigel Medical different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable ADDRESS: Bracken Hill capabilities for biomarker discovery, signal results and our scientists’ communication South West Industrial Estate transduction pathway analysis, protein skills ensure that you will understand them. ” Peterlee County Durham expression analysis, protein identification, POSTCODE: SR8 2SW quantification and characterisation.

For further information visit: www.nepaf.com WEB: www.rigelmedical.com Rigel Medical is a division within Seaward, market leader in providing electrical With its main laboratory located on the John Backes safety solutions. Designed by the Liverpool Hospital University, Rigel launched the CONTACT: campus of Newcastle University and a world’s first IEC 601 electrical safety analyser, known as the Rigel 8001 Liverpool JOB ROLE: Sales & Product Manager second laboratory located on the campus of Safety Tester. johnb@rigelmedical.com Durham EMAIL: University, NEPAF is supported by Within the next two years, the IEC 62353, a dedicated International Standard the regional development agency One North for Routine Electrical Safety Testing is expected to provide guidelines in making TEL: 0191 5878745 East and the European Regional Development 0191 5860227 dedicated Safety Testing routines for BioMedical Test Equipment designed to IEC FAX: Fund. In 2007 Cels secured £4 million to 60601. develop the facility, which is the only one of its kind in the North East of England.

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 3 1

A B

P R O T E O M I C S Rocket F U Medical TUR Plc E OF BIOTECHNOLOGY

C D E

ADDRESS: Sedling Road Washington Tyne and Wear POSTCODE: NE38 9BZ

WEB: www.rocketmedical.com

F

CONTACT: Dave Hill JOB ROLE: Design Manager EMAIL: dave@rocketmedical.com TEL: 0191 4194488 FAX: 0191 4165693

Rocket Medicals core focus is design and manufacturing on seven primary clinical areas: Cardiothoracic, Perfusion, MIS, IVF/Infertility, Interventional Radiology, Obstetrics, and Women’s Healthcare.

Rocket Medical currently produces over 1900 product lines in its UK factory using a range of manufacturing skills

G Signalway Antibodies

H I

J K L M N O P Q R S T U V W X Y Z

ADDRESS: Office 34 Gateshead International Business Centre Mulgrave Terrace Tyne and Wear POSTCODE: NE8 1AN CONTACT: Yaoyao Xu TEL: 0191 4909 208

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

SAB provides custom antibodies to customers worldwide, including researchers at universities and in biotechnological and pharmaceutical companies. With more than 20 years in academic antibody research and monoclonal antibody works’ experiences, our scientists are very happy to help you in the design and selection of antigen epitomes and the production of numerous antibodies.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit healthy cellCompany from those in a The You diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: Unit 10 a small number of proteins are separated out be a symptom of the disease, in which case Bearl Farm from all other proteins in Stocksfield the cell or organism they could help diagnose the disease much Northumberland and studied in great detail.

Although this earlier, and thus improve the prognosis for POSTCODE: NE43 7AJ approach remains very valuable it misses out the patient, or the different proteins may be some important information.

Proteins do not the cause of the disease, in which case they WEB: www.theyoucompany.com The Youagainst Company is the developer cost, much self administered exist in isolation from each other, so although could act as targets which new drugs of aOflow course of this was health promised from Paul Jobling screening system. The system utililises online data interpretation and onscreen studying pureCONTACT: proteins removes interference can be developed. the earliest days of proteomics, and it has presentation of results. The system has been designed to dectect early

JOB ROLE: Marketing Director from other proteins it also reduces a lot of the to beoccur said and the results so far have indications of pathology before symptoms helps alert users tonot risk lived factors associated with chronic disease.

EMAIL: paul.jobling@theyoucompany.com complexity and interaction which is actually a up to expectations. This is in part because of how proteins work. key part the technology has had to catch up with TEL: 01661 845990 the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Thermo Fisher Scientific ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Unit 9 to map out all the proteins in any handle the immensely large and complex data Atley Waygiven cell or North Nelson Industrial organism, at a given time.

Once you can do Estate generated by this research has also increased this it enables you to trulyCramlington understand how the exponentially over the decade, and finally, but Northumberland chemical building blocks of life truly interact. perhaps most importantly, the people working NE23 1WA POSTCODE: in the field have had to develop and perfect www.thermofisher.com Thermo Fisher Scientific (NYSE: TMO) employs 30,000 people and serves WEB:is rather In a way, the genome like a dictionary new techniques and methods toover allow them 350,000 customers within pharmaceutical and biotech companies, hospitals which contains a list of all the possible words to generate and interpret robust reliable data. and clinical diagnostic labs, universities, research institutions and government CONTACT: John Davies in a language, whereas the proteome is more agencies, as well as environmental and industrial process control settings. It offers john.davies@thermofisher.com clinical diagnostic capabilities and ways is a total provider has of products and like the individualEMAIL: books in that language, Since differentend-to-end cell types can be characterised In many proteomics finally caught services to diagnostic lab settings including equipment, consumables, supplies these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no and services.

TEL: 01670 706710 needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 3 2 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Visitech International

WEB: www.visitech.co.uk

B

ADDRESS: Unit 92 Silverbriar Sunderland Enterprise Park (East) Sunderland Tyne and Wear POSTCODE: SR5 2TQ

CONTACT: Jafer Sheblee JOB ROLE: Managing Director EMAIL: js@visitech.co.uk TEL: 0191 516 6255

C VisiTech International’s mission is to provide high quality innovative and novel imaging instrumentation and associated peripherals to the life science community. Customer focus is VisiTech’s first priority and we aim to provide solutions that best fit the laboratory scientist’s experimental needs.

With our headquarters in Sunderland, UK, our roots can be traced back to Joyce Loebl Ltd; one of the pioneering companies in image processing technology, and Applied Imaging, a leading supplier of Life Science instrumentation.

D E F G H I J K

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

The facility will give clients access to expertise in the use of proteomics for drug discovery, development and manufacture and in the diagnosis and monitoring of disease.

The facility provides a range of services including protein extraction, using one of the first pressure cycling homogenisers in the UK, protein separation using 2-D Polyacrylamide Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide capabilities for biomarker discovery, signal transduction pathway analysis, protein expression analysis, protein identification, quantification and characterisation.

With its main laboratory located on the campus of Newcastle University and a second laboratory located on the campus of Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

Dr Glen Kemp , project manager, NEPAF says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development using proteomics that will secure the reputation of the North East as the place to do biotech business.”

Achim Treumann, scientific manager of NEPAF says: “Our aim at NEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic and commercial research. The level of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com

L M N O P Q R S T U V W X Y Z W W W . C E L S G R O U P. C O M 1 3 3

dis.tinc.tive [di-stingk-tiv] - adjective 1. serving to distinguish; characteristic; distinguishing: the distinctive spots of the leopard.

2. having a special quality, style, attractiveness, etc.; notable.

- distinctively a. distinctiveness n.

7th Floor | Aidan House | Sunderland Road | Gateshead | NE8 3HU T: 0191 478 83 00 | E: enquiries@distinctivegroup.co.uk

be well, connected

Driving the business of life sciences

S U P P LY C H A I N

A B

P R O T E O M I C S AAF F International U T U RLtdE OF BIOTECHNOLOGY

C D E

ADDRESS: Bassington Lane Cramlington Northumberland POSTCODE: NE23 8AF

WEB: www.aafeurope.com

F

CONTACT: Eileen Andrews JOB ROLE: National Sales Manager

The company is a specialist in the field of cleanroom air filtration components with a wide range of particulate HEPA and ULPA filters and chemical filters to meet their clients’ requirements with respect to clean air. Complete cleanroom air filtration systems with a system guarantee are available.

EMAIL: eandrews@aafgb.com TEL: 01670 566188 FAX: 01670 590262

In addition they manufacture a comprehensive range of air filtration products for general HVAC applications.

G Aesica Pharmaceuticals Ltd

H I

J

WEB: www.aesica-pharma.com

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: Q5, Quorum Business Park Benton Lane Newcastle upon Tyne POSTCODE: NE12 8BS

CONTACT: Maria Koustareva JOB ROLE: Marketing Manager EMAIL: marketing@aesica-pharma.com TEL: 0191 2181960 FAX: 0191 2669447

Aesica is an innovative and service driven supplier of APIs, formulated products and custom synthesis solutions to the global pharmaceutical and biotechnology industries. Aesica provides a tailored service incorporating integrated project management and working in partnerships on all projects, from individual development and scale-up to large-scale commercial manufacturing and technical transfers.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteins a fit healthy cell from those in a What is more, since proteomics can Alcanin Packaging Cramlington Ltd diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural

ADDRESS: 49 Colbourne Avenue a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Nelson Park from all other proteins in Cramlington the cell or organism they could help diagnose the disease much crops and more efficient biofuels, and in Northumberland and studied in great detail.

Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to POSTCODE: NE23 1WD approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity. some important information.

Proteins do not the cause of the disease, in which case they WEB: www.cramlington. alcanpackaging.com exist in isolation from each other, so although could act as targets against which new drugs Of course much of this was promised from Alcan is the UK’s leading supplier of Primary Flexible Packaging to the studying pure proteins removes interference can be developed. the earliest days of proteomics, and it has pharmaceutical and healthcare industries. products include: CONTACT: Penny Bush from other proteins it also reduces a lot of the saidPack the results Marketing Services • Hard and Soft Temper Lacquered foil to forbe Blister Liddingso far have not lived

JOB ROLE: • Foil based Laminates for Sachets complexity and interaction which is actually a up to expectations. This is in part because • Child Resistant Blister Lidding solutionsthe technology has had to catch up with key part of how EMAIL: proteins penny.bush@alcan.com work.

• Guardlid

the theory. Some of the equipment used for • Cold Form Laminate for alu/alu Blisters TEL: 01670 730684 Proteomics aims to redress this by embracing • N’Crypt - security and anti-counterfeitproteomics, solutions such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic Amtech Rapid Prototyping Ltd to discover more proteins, more accurately ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Unit 2 Finlay Court to map out all the proteins in any given or Estate handle the immensely large and complex data Simonside East cell Industrial South Shields organism, at a given time.

Once you can do generated by this research has also increased 9QA POSTCODE: this it enables you to trulyNE34 understand how the exponentially over the decade, and finally, but chemical building WEB: blockswww.amtech-rp.co.uk of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect Ian Judd Providing a rapid prototyping services to manufactures, designers andtoindividuals In a way, theCONTACT: genome is rather like a dictionary new techniques and methods allow them which includes:

JOB ROLE: Managing Director which contains a list of all the possible words to generate and interpret robust reliable data. in a language, whereas proteome is more info@amtech-rp.co.uk • Stereolithography (SLA) - Accurate, detailed models from your CAD data.

EMAIL: the Production-quality In components soft (silicon) tooling individual books in that language, like the Since different• Vacuum cell typesCasting can be-characterised many waysusing proteomics has finally caught delivered in as little as 4 days.

TEL: 0191 4541990 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no • Selective Laser Sintering (SLS) - Strong, functional models from Nylon (Duraform).

FAX: 0191 4541901 needed to tell the story, and the way in which proteomics can be used to studyModelling how more components challenges toinovercome, we are • Fused Deposition (FDM) - Sturdy actual ABSbut material. those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

1 3 6 C E L S H E A LT H C O N N E C T

changing as it ages and even in response to changes from outside and within.

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

ANP (N.E.) Ltd

B

ADDRESS: 26 Mill Road Chopwell Tyne and Wear POSTCODE: NE17 7AH

C

WEB: www.anpltd.co.uk

CONTACT: Allen Phillips JOB ROLE: Director EMAIL: anpltd@fsmail.net TEL: 01207 562182

ANP (N.E.) Ltd, are suppliers of biodegradable products and equipment for specialist use in the Health and Food Sectors and specialist cleaners of floors (carpets or hard flooring), office chairs and upholstery e.g. sofas in reception, leather cleaning & protection.

We specialise in creating good Indoor Air Quality for a Healthy Environment.

Guarantee to kill everything up to e-coli. Cleans, deodorises & applies an antistatic coating in one operation.

D E F G

C2MUK Ltd

ADDRESS: Suite 48 Gear House Saltmeadows Rd Gateshead Tyne and Wear UK POSTCODE: NE8 3AH WEB: www.c2muk.co.uk

CONTACT: Gary Thompson JOB ROLE: Managing Director

H I J

Product Design Consultants providing innovative solutions to product and service based problems. Primarily setup to support and help UK manufacturing to flourish, C2M is built with over 20 years of front-line engineering experience to provide clients with technical and practical solutions.

EMAIL: NEPAF (the Northenquiries@c2muk.co.uk East Proteome Analysis Through Cels, NEPAF has a dedicated Facility) will work with a wide range of research team of six scientists, including experienced 0191 4901154 TEL: and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and will provide Centre Dr Glen , project manager, NEPAF For Kemp Design Research (CfDR) them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art ADDRESS: School of Design facilities that allow even the smallest of City Campus East The facility will give clients access to expertise companies to carry out the research they Northumbria University Newcastle Tyne in the use of proteomics for upon drug discovery, need. NEPAF’s goal is to support companies 8ST POSTCODE: development andNE1 manufacture and in the carrying out significant and, in some cases, diagnosis WEB: and monitoring of disease. ground-breaking research and development www.cfdr.co.uk usingCfDR proteomics that will secure the of designers, drawn from industry, delivering is a multidisciplinary team Bruce Watson commercially focused services to Regional, National and CONTACT: The facility provides a range of services reputation of the North East research-led as the place design to International clients.

JOB ROLE: Consultancy Manager including protein extraction, using one of the do biotech business.” first pressure cycling homogenisers in the UK, AchimWe Treumann, scientific manager ofin the fields of industrial design, interaction bruce.watson@northumbria. provide ‘user-centred’ design EMAIL: ac.uk design, protein separation using 2-D Polyacrylamide NEPAF says: conceptual “Our aim at design NEPAFresearch, is to use innovation management, medical product design, and new media.

TEL: Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions 0191 2437063 multi-dimensional liquid chromatography for real world problems.

Our The CfDRbiochemical is an approved supplier for ‘User Centred Design’ to the NHS Institute.

(MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic ChemiSPEC and commercial research. The level different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable ADDRESS: Darwin Building capabilities for biomarker discovery, signal results and our scientists’ communication University of Sunderland transduction pathway analysis, protein skills ensure that you will understand them. ” Wharncliffe Street Sunderland expression analysis, protein identification, POSTCODE: SR1 3SD quantification and characterisation.

For further information visit: www.nepaf.com CONTACT: Bill Cambell At chemiSPEC we help customers in a wide range of industry sectors - including With its main laboratory located on the pharmaceutical, fine and specialty chemicals and health care - with the bill.c.campbell@gmail.com characterisation of their products, by products, contaminants, etc. campus EMAIL: of Newcastle University and a second laboratory located on the campus of TEL: 0191 5153860 • Provision of NMR and MS spectra to your desktop Durham University, NEPAF is supported by • Spectral Interpretation • Complex Mixture Analysis the regional development agency One North • LC-MS and LC-NMR Analysis East and the European Regional Development • Structure Elucidation Fund. In 2007 Cels secured £4 million to • Method Development develop the facility, which is the only one of its kind in the North East of England.

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 3 7

A B

P R O T E O M I CClassic S FIndustries UTU R Inc E Ltd Europe OF BIOTECHNOLOGY

C D

ADDRESS: Kirkcarrion Estate Gas Lane Middleton in Teesdale Barnard Castle County Durham POSTCODE: DL12 0TN WEB: www.classicind.com

E

F

Classic Industries established in 1983 is recognised today as a key supplier of plastic injection moulded parts to pharmaceutical and medical manufacturers worldwide.

CONTACT: John Pearson JOB ROLE: General Manager

Dedicated to satisfying the most rigorous of regulatory standards for the most demanding industries, Classic Industries segregated, all electric moulding shop is designed to run 24 hours a day, 7 days a week for 50 weeks of the year

EMAIL: lpearson@classicind.com TEL: 01833 640050 FAX: 01833 640995

G H

Connor Solutions

I J K L M N O P Q R S T U V W X Y Z

ADDRESS: Rainton Bridge South Business Park Houghton Le Spring Tyne and Wear POSTCODE: DH4 5NL WEB: www.connorsolutions.co.uk

CONTACT: Richard Whitehead JOB ROLE: Director EMAIL: richard.whitehead@ connorsolutions.co.uk TEL: 0191 5121555

As one of the UK’s foremost electronics manufacturing service providers, Connor Solutions can provide: • Design for Manufacture (DfM) • Volume manufacturing • Test • Country configuration

• Dedicated prototype facilities • Global sourcing • Systems assembly • Logistics and warranty

changing as it ages and even in response to to give us important insights in the ageing already operating withinSo thethere medical industry changes fromWe outside andprovide within.services for companies process as a whole. are scientific and are on track to receive ISO13485 approval in early 2010. questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteins in a fit healthy cell from those in a What is more, since proteomics can Cundall diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences.

These different proteins may just increasingly being used in agricultural ADDRESS: Horsley House a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Gosforth from all other proteins in Newcastle the cell or organism they could help diagnose the disease much crops and more efficient biofuels, and in POSTCODE: NE3 3LU and studied in great detail. Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to approach remainsWEB: very valuable it misses out the patient, or the different proteins may be harness their amazing diversity. www.cundall.com some important information. Proteins do not the cause of the disease, in which case they CONTACT: Duncan Cox A multidisciplinary practice of consulting withof a this strong reputation exist in isolation from each other, so although could act as targets against which new drugs Ofengineers, course much was promisedbuilt from

JOB ROLE: Associate on providing excellent service and sustainable, high quality design solutions. studying pureCONTACT: proteins removes interference can be developed. the earliest days of proteomics, and it has Stephen Clough Recently we have successfully designed the new Centre for Bacterial Cell Biology

JOB ROLE: from other proteins it alsoPartner reduces a lot of the to be said the results so far have not lived for Newcastle University and three buildings for the Campus of Ageing and Vitality at Newcastle General Hospital. up to expectations. This is in part because complexity and interaction which is actually a EMAIL: d.cox@cundall.com key part proteins s.clough@cundall.com work. the technology has had to catch up with of how EMAIL: the theory. Some of the equipment used for 0191this 2131515 Proteomics aims toTEL: redress by embracing proteomics, such as high resolution mass FAX: 0191 2131701 the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic Design Right Solutions (DRS) to discover more proteins, more accurately ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to29 provide a means amount of computing power required to Unit

ADDRESS: North Eastgiven of England to map out all the proteins in any cell or Business handle the immensely large and complex data and Innovation organism, at a given time.

Once you canCentre do generated by this research has also increased Sunderland Enterprise Park (East) this it enables you to trulyWearfield understand how the exponentially over the decade, and finally, but chemical building blocksSunderland of life truly interact. perhaps most importantly, the people working POSTCODE: SR5 2TA in the have had to develop and perfect Design Right Solutions is a highly creative multifield disciplined group, specialising in In a way, the genome is rather like a dictionary new techniques and methods to allow them new product design & development.

WEB: www.designrightsolutions.co.uk which contains a list of all the possible words to generate and interpret robust reliable data.

DRS offer their clients a whole range of services anything from IPR advice to full Rayproteome Rutter CONTACT: in a language, whereas the is more project management

JOB ROLE: General Manager like the individual books in that language, Since different• cell typesdesign can be characterised manyrealistic ways proteomics has finally caught Product •InPhoto Visualisation • Electronic Design • Rapid Prototyping these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no EMAIL: ray.rutter@designrightsolutions.co.uk • Concept sketchwork • Project Management to tell the story, and the way in which needed proteomics can be used to study how more challenges to overcome, but we are • Solidworks CAD • Commercialisation TEL: 0191 5166099 those words interact dictates how the story embryonic stem cells can develop into any in a3Dbetter position than ever before to • Design for manufacture/assembly •now 2D to conversions is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

The term Proteomics coined 0191only 5121666 FAX: was around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

1 3 8 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Durham University

B

ADDRESS: Knowledge Transfer office Old Elvet Durham POSTCODE: DH1 3HP

C

WEB: www.dur.ac.uk

CONTACT: Prof Brian Tanner JOB ROLE: Dean of Knowledge Transfer EMAIL: b.k.tanner@durham.ac.uk TEL: 0191 3343677

Our aim is to enhance the exploitation of the Intellectual Property generated by the high quality research activities; maintain a climate in which the exploitation of Intellectual Property generated in the course of research activity is a normal and automatic consideration; contribute to the overall University mission, recognising the core teaching, research and ‘third-leg’ strategies of the University and our activities are designed to support staff in pursuing them.

D E F G

e3Design Ltd

H

ADDRESS: 1 Jesmond Business Court 217 Jesmond Road Newcastle upon Tyne POSTCODE: NE2 1LA

I J

WEB: www.e3design.co.uk

CONTACT: Richard Parker EMAIL: richard@e3design.co.uk TEL: 0191 2399356

We are creative product designers.

Working with businesses and entrepreneurs, we design & develop products, investigate technologies and prototype concepts.

Our consumer-focused approach, know-how and innovation is targeted to

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: PO Box 405 Newcastle upon Tyne NE3clients 9AB access to expertise ThePOSTCODE: facility will give

in the use of proteomics for drug discovery, WEB: www.embryonyx .co.uk development and manufacture and in the Angus Long CONTACT: diagnosis and monitoring of disease.

JOB ROLE: Director

The facility provides a range of services angus@embryonyx.co.uk EMAIL: including protein extraction, using one of the 07968 421428 TEL: first pressure cycling homogenisers in the UK, FAX: 0191 2363112 protein separation using 2-D Polyacrylamide Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein system. Sunset These House instruments provide arraying ADDRESS: capabilities for biomarker signal Appletondiscovery, Moors York analysis, protein transduction pathway POSTCODE: YO62 6TE expression analysis, protein identification, quantification characterisation. www.empatec.com WEB:and Linda Rawlings With CONTACT: its main laboratory located on the

JOB ROLE: Director campus of Newcastle University and a EMAIL: linda@empatec.com second laboratory located on the campus of Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

create products and sell.

Through Cels, NEPAF that has work a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

K L M

Dr GlenEmbryonyx Kemp , project manager, Ltd NEPAF says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development usingEmbryonyx proteomicsprovides that will Commercial secure the Consultancy, specialising in the Healthcare Industry.

Services include: reputation of the Northprovided East as the placeSales to & Marketing, Product Management, Promotional Practice, Public Relations, Project Management, Public Sector, do biotech business.”

Procurement and Tendering. In particular, a thorough understanding of primary, Achimsecondary Treumann,and scientific manager of provision within the UK. Embryonyx also palliative healthcare distributes a range vascular exercising devices.

NEPAF says: “Our aim atofNEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic and commercial research.

The level empatec reglatory services of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com empatec regulatory services provides practical regulatory help and advice to companies who are developing, manufacturing, marketing or licensing pharmaceuticals, APIs, biotech and devices.

We provide dossier preparation services including Marketing Authorisation Applications / Variations / Clinical trials / Summaries, and will manage procedures, liaison with regulatory agencies and preparation for scientific advice. We advise clients on issues ranging from regulatory strategy to Quality Systems.

N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 3 9

A B

P R O T E O M I C S Honeyman F U TGroup U RLtdE OF BIOTECHNOLOGY

C D E

ADDRESS: Harmire Enterprise Park Barnard Castle County Durham POSTCODE: DL12 8BN WEB: www.honeyman.co.uk

F

CONTACT: Lindsay Monaghan JOB ROLE: Marketing Manager EMAIL: enquiries@honeyman.co.uk TEL: 01833 690101 FAX: 01833 690102

Honeyman provides many of the world’s leading pharmaceutical, healthcare, medical device manufacturers and biopharmaceutical companies with innovative solutions to enhance their product development and manufacturing processes. Offering more than standard contract testing services, the Honeyman Group’s MHRA approved laboratory provides a full range of chemical, microbiological and endotoxin analyses including cleaning validation and disinfectant efficacy studies in support of a broad range of pharmaceutical processes and activities.

G IDEC Validation Ltd

H I

J

WEB: www.idecvalidation.co.uk

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: Concorde House Concorde Way Stockton on Tees Cleveland POSTCODE: TS18 3RB

CONTACT: David Whitney JOB ROLE: Managing Director EMAIL: david.whitney@idec.ltd.uk TEL: 07970 827820

IDEC Validation Ltd formed in 1999 in order to provide Quality and Compliance services to the Pharmaceutical, Biotech and Medical Device Industries. IDEC consultants and practitioners provide pragmatic advice and support to its customers. This ensures quantifiable benefits through the establishment of a quality culture, organisation and processes that provide effective compliance with pharmaceutical industry standards. IDEC Validation actively participates in industry forums such as the ISPE GAMP Forum

The term Proteomics was only coined changing as it ages and even in response to to give us important insights in the ageing around 14 years ago, making it a relatively changes from outside and within. process as a whole. So there are scientific new science. It was developed to address questions proteomics can help us answer, a key limitation in classical protein For example if you could compare the literally from cradle to grave. biochemistry. proteins in a fit In healthy cell from those in a Exploitation) What is more, since proteomics can Inex (Innovation Nanotechnology diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences.

These different proteins may just increasingly being used in agricultural ADDRESS: Herschel Building a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food Newcastle University upon Tyne from all other proteins in Newcastle the cell or organism they could help diagnose the disease much crops and more efficient biofuels, and in Tyne and Wear and studiedPOSTCODE: in great detail.

Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to NE1 7RU approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity.

WEB: www.inex.org.uk some important information.

Proteins do not the cause of the disease, in which case they INEX is a against MEMS and specialist contract manufacturer, performing exist in isolation from each other, so although could act as targets which newelectronic drugs device Of course much of this was promised from CONTACT: Angela Silmon custom process development and high-added value device manufacturing. We provide studying pure proteins removes interference can be developed. the earliest days of proteomics, and it has

JOB ROLE: Business Area Manager: integrated solutions in microsystems and nanotechnology enabled applications and from other proteins it alsoBiosciences reduces a lot of the to be said the results so far have not lived products. Our activities include: • Point-of-care diagnostic product incorporating andThis DNAis sensor technology complexity and interaction which is actually a up to microfluidic expectations. in part because EMAIL: a.m.silmon@newcastle.ac.uk • Biosensors for pharmaceutical high-throughput screening and security key part the technology hashomeland had to catch up with of how proteins work. applications TEL: 0191 2223500 the theory.

• Surface biofunctionalisation for nerve damage repair Some of the equipment used for 0191 2223528 FAX: Proteomics aims to redress this by embracing proteomics, high resolution mass • Long-term flexible medical implants for nerve stimulationsuch and as regeneration the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Intertek MSG ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: The Wilton Centre to map out all the proteins in any given cell or handle the immensely large and complex data Redcar Cleveland organism, at a given time.

Once you can do generated by this research has also increased 4RF POSTCODE: this it enables you to trulyTS10 understand how the exponentially over the decade, and finally, but chemical building WEB: blockswww.intertek.com of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect Allan Stewart In a way, theCONTACT: genome is rather like a dictionary new techniques and methods to allow them Analysis, characterisation, problem-solving and consultancy are offered to

JOB ROLE: Business Development Director which contains a list of all the possible words to generate and interpret robust reliable data. customers in production, product development, research and technical service. in a language, whereas proteome is more msgenqiory@intertek.com Our clients benefit from having the expertise of our team of world-class scientists EMAIL: the to their often in multi-technique problem-solving situations. individual books in that language, like the Since differentapplied cell types can problems, be characterised In many ways proteomics has finally caught TEL: 01642 435788 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no Intertek MSG is increasingly active in areas such as pharmaceuticals, medical needed to tell the story, and the way in which proteomics can be used study how more new challenges to overcome, we are devices andtoelectronic materials, and seeks contacts and clients but in these fields. those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 4 0 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Ithaka Life Sciences

WEB: www.ithaka.co.uk

B

ADDRESS: The NetPark Incubator Thomas Wright Way NetPark Sedgefield County Durham POSTCODE: TS21 3FD

CONTACT: Dr John Adair JOB ROLE: Senior Consultant

C Ithaka was established in 2000 and has quickly built a reputation as one of the UK’s leading consultancy and interim management services provider, specialising in new and growing life science businesses. In addition to individual technical expertise Ithaka’s team all have direct experience in founding and growing life science companies.

EMAIL: john.adair@ithaka.co.uk

D E F

TEL: 01740 625 270

G Kinneir Dufort

WEB: www.kinneirdufort.com TEL: 0191 305 5009 FAX: 0191 305 5481

H

ADDRESS: e.volve Business Centre Rainton Bridge South Business Park POSTCODE: County Durham DH4 5QY

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: 3 Ellison Terrace Newcastle NE1clients 8ST access to expertise ThePOSTCODE: facility will give

in the use of proteomics for drug discovery, CONTACT: Mark Jackson development and manufacture and in the m.jackson@knowledge diagnosisEMAIL: and monitoring of disease. house.ac.uk

The facility provides range of services TEL: 0191a 2048863 including protein extraction, using one of the first pressure cycling homogenisers in the UK, protein separation using 2-D Polyacrylamide Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide

ADDRESS: Wood Manor capabilities for biomarker discovery, signal Wood Street transduction pathway analysis, Shotley Bridge protein County Durham expression analysis, protein identification, POSTCODE: DH8 0JE quantification and characterisation.

CONTACT: Andrew Lyddiatt Bioprocess Consultant With JOB ROLE: its main laboratory located on the

campus of Newcastle University and a

EMAIL: al@lyddallan.co.uk second laboratory located on the campus of 583615 TEL: 01207 Durham University, NEPAF is supported by

the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

I J Kinneir Dufort is an award winning design consultancy. With particular expertise in the international medical industry, innovation and technology are combined to provide successful new product development. Projects are taken from user research and concept generation to mechanical engineering, prototyping and specification for volume manufacture. Products designed include consumer and clinical diagnostics, drug delivery and dispensing devices, surgical instruments andCels, point-of-care equipment.

Through NEPAF has a dedicated

team of six scientists, including experienced practitioners in the field of proteomics.

K L M

Dr Glen Kemp , project House manager, NEPAF Knowledge says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development Knowledge House is a collaborative service offered by the five North East usingUniversities proteomicsthrough that willUniversities secure thefor the North East (Unis4NE) to help companies reputation of University the Northskills, Eastexpertise as the place access and to specialist resources. do biotech business.”

Working together across a wide range of disciplines including industrial design, AchimIT,Treumann, scientific manager of manufacturing, marketing, life sciences and environmental issues, Knowledge NEPAF says:offers “Ourexpert aim atsolutions NEPAF is use House fortodeveloping ideas and solving problems through collaboration, consultancy, training and research. leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic and Consultancy commercial research.Ltd The level Lyddallan of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com

N O P Q R S T U V W

Lyddallan Consultancy offers technical and strategic consultancy services in the field of bioprocess technology, underpinned by thirty five years experience in academic and corporate research, development and manufacture. Practical skills available in the design, implementation and trouble-shooting of integrated bioprocesses for the manufacture of natural and genetically engineered bioproducts. Innovative solutions to technical problems and network sources for customised solutions are a speciality.

X Y Z

W W W . C E L S G R O U P. C O M 1 4 1

A B

P R O T E O M I C S FMCB UAssociates TURE OF BIOTECHNOLOGY

C

ADDRESS: 16 Northbourne Ave Morpeth Northumberland POSTCODE: NE61 1JG

WEB: www.mcb-associates.co.uk

D E

F

CONTACT: Mary Buckland JOB ROLE: Managing Director EMAIL: nowwishes.4training@yahoo.co.uk TEL: 07713 709210

Established in 1997, MCB Associates will deliver Industrial Training to your requirements. We always aim: • To meet your training needs • To see your needs as paramount • To deliver what we promise, on schedule • To ensure your scheme is delivered • To deliver with minimal overheads

G Micro-Tek Systems Ltd

H I J K L M N O P Q R S T U V W X Y Z

ADDRESS: 21 Sherburn Park Drive Rowlands Gill Tyne and Wear POSTCODE: NE39 1QR CONTACT: Colin Arrowsmith JOB ROLE: Director EMAIL: colin@kbodynamics.com TEL: 01207 542186

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

We have specialised in the design and prototyping of electronic controls in the healthcare, white goods and automotive arenas for over ten years. We can undertake all aspects of the design process from initial concept to generating prototype systems using our rapid PCB prototyping milling machine. Our partner companies if required can also undertake both small and large-scale production.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteinsnano-porous in a fit healthy cell from those in a Ltd solutions diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just Dukesway ADDRESS: a small number of proteins areValley separated outEstate be a symptom of the disease, in which case Team Trading from all other proteins in Gateshead the cell or organism they could help diagnose the disease much Tyne and Wear and studiedPOSTCODE: in great detail.

Although this earlier, and thus improve the prognosis for NE11 0PZ approach remains very valuable it misses out the patient, or the different proteins may be WEB: www.n-psl.com some important information.

Proteins do not the cause of the disease, in which case they nano-porous solutions limited are developing novel adsorbent hollow fibres, from exist in isolation from each other, so although could act as targets against which new drugs Of course much of this was promised CONTACT: Neil McPherson which can be tailored to customers’ requirements. Fibres are currently being studying pure proteins removes interference can be developed. the earliest days of proteomics, and it has

JOB ROLE: Business Development Director developed for the adsorption of water, carbon dioxide and volatile organic compounds from gas streams. Benefits to over granular from other proteins it also reduces a lot of the be conventional said the results so far materials have not lived EMAIL: neil.mcpherson@n-psl.com include improved kinetic and the ability in any orientation. complexity and interaction which is actually a uptotoinstall expectations.

This is in part because

key part of how proteins work. the technology has had to catch up with TEL: 0191 4977700 FAX: 0191 4977709 the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Northern Elevator Ltd ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to Walker Davison House

ADDRESS: Suite 2 given cell or to map out all the proteins in any handle the immensely large and complex data High Street organism, at a given time.

Once you can do generated by this research has also increased Newburn this it enables you to trulyNewcastle understand how the exponentially over the decade, and finally, but upon Tyne chemical building blocksNE15 of life8LN truly interact. perhaps most importantly, the people working POSTCODE: in the field have had to develop and perfect WEB: www.northern-elevator.com Northern Elevator Ltd is a customer focused service provider for all lift engineering In a way, the genome is rather like a dictionary new techniques and methods to allow them requirements whoever the original manufacturer. which contains a list of allTerry the Murtagh possible words to generate and interpret robust reliable data.

CONTACT: Managing Director

JOB ROLE: the in a language, whereas proteome is more We specialise in maintenance, call outs, repairs and modernisation up-grades to types of lift equipment, as well as new lift installations. like the individual books in that language, Since differentallcell types can be characterised In many ways proteomics has finally caught TEL: 0845 0531186 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no FAX: 0845 0531186 needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 4 2 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

NPE Ltd

B

ADDRESS: Buddle Industrial Estate Benton Way Wallsend Tyne and Wear POSTCODE: NE28 6DL

C

WEB: www.npe.uk.com

Precision Engineers. Established in 1975 and today employing over 60 people in its modern 35,000 sq ft factory. Using the latest materials applied to medical science, NPE use traditional and cellular manufacturing processes to produce complicated prosthetic components as a key area of their service offering expertise.

CONTACT: Iain Oates JOB ROLE: Managing Director EMAIL: iaino@npe.uk.com

D E F

TEL: 0191 2636666 FAX: 0191 2630356

G Octo Product Development Ltd

WEB: www.octodesign.co.uk

CONTACT: Julie Patterson JOB ROLE: Business Development Manager

EMAIL: juliep@ocotdesign.co.uk NEPAF (the North East Proteome Analysis TEL: 0191 4693888

H

ADDRESS: Design Works William Street Felling Gateshead Tyne and Wear POSTCODE: NE10 0JP

Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: 2 Coniston Court Coniston Road Riverside The facility will give clientsBusiness access Park to expertise Blyth in the use of proteomics for drug discovery, Tyne and Wear development andNE24 manufacture and in the 4RP POSTCODE:

diagnosis and monitoring of disease.

WEB: www.omega-plastics.co.uk

The facility provides a range Dave Croneof services CONTACT: protein Operations extraction, Director using one of the including JOB ROLE: first pressure cycling homogenisers in the UK, EMAIL: dave.crone@omega-plastics.co.uk protein separation using 2-D Polyacrylamide

Gel Electrophoresis (2D-PAGE) 541890 and TEL: 01670 FAX: 01670 multi-dimensional liquid541891 chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein system. Unit These 2E instruments provide arraying ADDRESS: capabilities for biomarker discovery, signal Admiral Business Park Nelsonanalysis, Way transduction pathway protein Nelson Park West expression analysis, protein identification, Cramlington quantification andNorthumberland characterisation.

POSTCODE: NE23 1WG

With its main laboratory located on the WEB: www.opsoluk.co.uk campus of Newcastle University and a Malcolm CONTACT: second laboratory locatedHumble on the campus of Durham JOBUniversity, ROLE: Director NEPAF is supported by the regional development agency One North malcolm@opsoluk.co.uk EMAIL: East and the European Regional Development 01670 590646 TEL:Cels Fund. In 2007 secured £4 million to FAX: 01670 590996 develop the facility, which is the only one of its kind in the North East of England.

I J Octo are a talented team of designers, engineers, strategists and thinkers who develop specialists products for professional markets.

We have the people, skill-set and depth of knowledge needed to take a product from conception to implementation. “Engineered Creativity” is the path we use to deliver solid return on investment and develop valuable intellectual property for our clients.

Through Cels, NEPAF has a dedicated

K L

team of six scientists, including experienced practitioners in the field of proteomics.

M

DrOmega Glen Kemp North , project manager, NEPAF East Ltd says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development usingOmega proteomics thatoffer will secure Plastics a rapidthe injection mould tools manufacture and moulding service.

OurNorth skilledEast toolmakers have to decades of experience each and personally reputation of the as the place project manage the workload through design-rationalisation; mould design; do biotech business.”

CADCAM; CNC; EDM; fitting; finishing; and proofing. Core services also include Achimbridge Treumann, scientific manager of to product moulded components and low volume production supply.

NEPAF says: “Our aim at NEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academicOpsol and commercial research. The level Uk Ltd of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ”

N

For further information visit: www.nepaf.com OPerational SOLutions is a supplier to UK Electronic Industry for electronic design, manufacture and outsourcing.

We provide UK manufacture from our facility in Cramlington Northumberland and as part of our continued growth we formed OPSOL ASIA. Based in Hong Kong with manufacturing partners and custom supply chain partners in China, this expansion further enhances our ability to provide competitive assembly and custom electronic component manufacture to the UK and Europe.

O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 4 3

A B

P R O T E O M I C S Peerless FUT U RLtdE Systems OF BIOTECHNOLOGY

C D E F

ADDRESS: 3 Brockwell Road Crowther Washington Tyne and Wear POSTCODE: NE38 0AF

WEB: www.peerless-systems.co.uk

Peerless have been providing bespoke laboratory automation for over 25 years. We have provided systems for a wide variety of industries worldwide.

Peerless, part of the Whiteley Murphy Group; who’s portfolio also contains Orwin International and Ancram Engineering. Orwin are one of the largest Automation houses in the UK.

CONTACT: Mark Lang JOB ROLE: Sales Manager EMAIL: sales@peerless-systems.co.uk TEL: 0191 4169866

G Paladin Consultants Ltd

H I

J

WEB: www.paladin-consultants.uk.com

K

L

M N O P Q R S T U V W X Y Z

ADDRESS: 6 Belsay Gardens Newcastle upon Tyne Tyne and Wear POSTCODE: NE3 2AU

CONTACT: Robert Pringle JOB ROLE: Director EMAIL: rdp@paladin-consultants.uk.com TEL: 07767 407994

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

Paladin was formed in 1980 to meet a market need for consultancy work in the area of embedded real-time systems for communications and industrial control.

The range of work has widened over the years to include Operating System Internals and Network (Wired and Wireless) and Security, Embedded Software Development and Information Security, development of products using very low power microcontrollers for hand-held battery-operated instruments has become a particular speciality.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit healthy cell from those in a Paragon Rapid Technologies diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: Block 11 a small number of proteins are separated out be a symptom of the disease, in which case Teesside Airport Industrial Estate from all other proteins in Middleton the cell or St. organism they could help diagnose the disease much George Darlington and studied in great detail.

Although this earlier, and thus improve the prognosis for County Durham approach remains very valuable it misses out the patient, or the different proteins may be POSTCODE: DL2 1PD some important information. Proteins do not the cause of the disease, in which case they www.paragon-rt.com Paragon have established as of the UK’soffinest rapidpromised prototyping WEB: exist in isolation from each other, so although could act as targets against which new themselves drugs Of one course much this was from bureau’s through consistently delivering the highest levels of quality and service, studying pure proteins removes interference can be developed. the earliest days of proteomics, and it has on time. Services cover a varied market including: Consumer Products, Medical EMAIL: sales@paragon-rt.com from other proteins it also reduces a lot of the to be said the results so far have not lived Devices, Automotive Design and Aerospace.

333141 TEL: 01325 complexity and interaction which is actually a up to expectations. This is in part because Core services include Stereolithography (SLA), Selective Laser FAX: 01325 key part of how proteins work. 332123 the technology has hadSintering to catch(SLS), up with product finishing, silicone tooling, vacuum casting, silicone moulding and low the theory.

Some of the equipment used for volume manufacture.

Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Resource Centre for Innovation and Design (RCID) ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: The Stephenson Building to map out all the proteins in any given cell or handle the immensely large and complex data Newcastle University Newcastle Tyne organism, at a given time.

Once youupon can do generated by this research has also increased and Wear this it enables you to trulyTyne understand how the exponentially over the decade, and finally, but POSTCODE: NE1 7RU chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect WEB: www.rcid.ncl.ac.uk Established in 1995 the Resource Centre for Innovation (RCID) In a way, the genome is rather like a dictionary new techniquesand and Design methods to allow them specialises in taking medical product concepts and ideas into working CONTACT: Rob Jamieson which contains a list of all the possible words to generate and interpret robust reliable data. prototypes. We work with relevant clinicians, academics and inventors to create JOB ROLE: CEO in a language, whereas the proteome is more and improve their ideas or early stage prototypes. RCID also enjoys a unique rcid.info@ncl.ac.uk with be Newcastle University which allows access to a range of Medical, like the individualEMAIL: books in that language, Since differentrelationship cell types can characterised In many ways proteomics has finally caught Engineering and Scientific facilities and expertise. these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no TEL: 0191 2225897 needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 4 4 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

Shasun Pharma Solutions Ltd

B

ADDRESS: Dudley Cramlington Northumberland POSTCODE: NE23 7QG

C

WEB: www.shasun.com CONTACT: Mike Gibson

EMAIL: mike.gibson@shasun.uk.com TEL: 0191 2500471 FAX: 0191 2501514

Shasun Pharma Solutions has over 40 years experience serving the global pharmaceutical industry. Offering state-of-the-art facilities, proprietary technologies and experienced people who are among the best in the industry, we have a proven track record in the supply of chemistry and analytical services across the entire product lifecycle, from grams to tonnes, from pre-clinical to commercial supply.

D E F G

Step Ahead Research

WEB: www.stepaheadresearch.co.uk

H

ADDRESS: Unit 4 Woods Pottery Stepney Bank Newcastle upon Tyne Tyne and Wear POSTCODE: NE1 2PN

CONTACT: Alastair Thomson JOB ROLE: Director TEL: 0191 2615299

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

I J Step Ahead Research has quickly established itself as a leading research consultancy, providing client-focused, innovative research solutions.

Our team of researchers have a wide range of skills and experience, encompassing the full spectrum of qualitative and quantitative techniques, and a practical understanding of the needs of our clients.

K L

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

M

Dr Glen KempCompliance , project manager, Ltd NEPAF Thermal

N

says: “The UK’s biotechnology sector is growing and in order for this growth to art

ADDRESS: Imperial Business Centre facilities that allow even the smallest of Grange Road The facility will give clients access to expertise companies to carry out the research they Darlington DL1 5NQfor drug discovery, POSTCODE: in the use of proteomics need. NEPAF’s goal is to support companies development and manufacture and in the carrying out significant and, in some cases, WEB: www.thermalcompliance.co.uk diagnosis and monitoring of disease. ground-breaking research and development Thermal Compliance Ltd is a specialist independent company delivering thermal usingmapping, proteomics that will secure the CONTACT: Chris Maughan validation and testing solutions to the healthcare, pharmaceutical and Managing Director The facility JOB ROLE: provides a range of services reputation of the North East as the place to biotechnology industries. includingEMAIL: protein chrism@thermalcompliance.co.uk extraction, using one of the do biotech business.”

Our Speciality is the Cycle Development and PQ of Autoclaves and Sterilisation first pressure cycling homogenisers in the UK, Achim Treumann, scientific manager of processes. We can provide full technical assistance in the set up and validation 6346714 TEL: 0845 protein separation using 2-D Polyacrylamide NEPAF “Our aim at NEPAF is to use of says: autoclaves.

Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions We also offer testing and maintenance to HTM standards on small bench top to multi-dimensional liquid chromatography for real world biochemical problems. Our large hospital autoclaves.

(MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and commercial research. The level Walker Filtration different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable

ADDRESS: Spire Road capabilities for biomarker discovery, signal results and our scientists’ communication Glover East transduction pathway analysis, protein skills ensure that you will understand them. ” Washington Tyneprotein and Wear expression analysis, identification, POSTCODE: NE37 3ES quantification and characterisation.

For further information visit: www.nepaf.com WEB: www.walkerfiltration.com Walker Filtration specialise in the design and manufacture of a wide range With its main laboratory located on the of industrial air filtration and drying technologies from compressed air filters, TEL: 0191 4177816 campus of Newcastle University and a vacuum pump filtration and medical sterile filters to laser smoke evacuators.

FAX: 0191 4153748 second laboratory located on the campus of Our product portfolio also includes heatless desiccant dryers and one of the most comprehensive ranges of alternative filter elements, air/oil separators and Durham University, NEPAF is supported by vacuum pump separators on the market today. the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 4 5

A B

P R O T E O M I C S FWHUPartnership TURE OF BIOTECHNOLOGY

C D E F

ADDRESS: 16 Bankside The Watermark Gateshead Tyne and Wear POSTCODE: NE11 9SY

WEB: www.wh-partnership.com

WH Partnership is a specialist engineering firm which provides a professional service to the Pharmaceutical, Biotechnology, Cosmetics, Health Care and Renewable Fuels industries.

CONTACT: Richard Anderson JOB ROLE: Director EMAIL: richard.anderson@wh-partnership. com TEL: 0191 4609295

Our core services encompass the full project life cycle from design, construction, commissioning and validation through to maintenance. We have also completed a number of laboratory refurbishments includig CAT3, aseptic suites and radio pharmacy within the NHS and private sector.

G H I J K L M N O P Q R S T U V W X Y Z

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

In the traditional approach a single protein or a small number of proteins are separated out from all other proteins in the cell or organism and studied in great detail. Although this approach remains very valuable it misses out some important information. Proteins do not exist in isolation from each other, so although studying pure proteins removes interference from other proteins it also reduces a lot of the complexity and interaction which is actually a key part of how proteins work.

Proteomics aims to redress this by embracing the complexity of a large number of different proteins in the same sample. Just as the human genome project allowed the genetic ‘plan’ of human beings to be deciphered, so proteomics, one day, aims to provide a means to map out all the proteins in any given cell or organism, at a given time. Once you can do this it enables you to truly understand how the chemical building blocks of life truly interact.

In a way, the genome is rather like a dictionary which contains a list of all the possible words in a language, whereas the proteome is more like the individual books in that language, these do not contain all the words, only those needed to tell the story, and the way in which those words interact dictates how the story is shaped, but unlike a book, the proteome is not fixed in time either, it is constantly

1 4 6 C E L S H E A LT H C O N N E C T

changing as it ages and even in response to changes from outside and within.

For example if you could compare the proteins in a fit healthy cell from those in a diseased cell, you will see some small but vital differences. These different proteins may just be a symptom of the disease, in which case they could help diagnose the disease much earlier, and thus improve the prognosis for the patient, or the different proteins may be the cause of the disease, in which case they could act as targets against which new drugs can be developed.

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

Since different cell types can be characterised by their own unique proteome fingerprint, proteomics can be used to study how embryonic stem cells can develop into any one of many different cell types, or it can look at the changes that occur in cells as they age

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

Of course much of this was promised from the earliest days of proteomics, and it has to be said the results so far have not lived up to expectations. This is in part because the technology has had to catch up with the theory. Some of the equipment used for proteomics, such as high resolution mass spectrometers, have improved greatly over the last decade, and now allow researchers to discover more proteins, more accurately and more quickly than ever before. The amount of computing power required to handle the immensely large and complex data generated by this research has also increased exponentially over the decade, and finally, but perhaps most importantly, the people working in the field have had to develop and perfect new techniques and methods to allow them to generate and interpret robust reliable data.

In many ways proteomics has finally caught up with itself, that is not to say there are no more challenges to overcome, but we are now in a better position than ever before to finally reap the rewards of this young and exciting field of science.

be well, connected

Driving the business of life sciences

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

The facility will give clients access to expertise in the use of proteomics for drug discovery, development and manufacture and in the diagnosis and monitoring of disease.

The facility provides a range of services including protein extraction, using one of the first pressure cycling homogenisers in the UK, protein separation using 2-D Polyacrylamide Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide capabilities for biomarker discovery, signal transduction pathway analysis, protein expression analysis, protein identification, quantification and characterisation.

With its main laboratory located on the campus of Newcastle University and a second laboratory located on the campus of Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

Dr Glen Kemp , project manager, NEPAF says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, ground-breaking research and development using proteomics that will secure the reputation of the North East as the place to do biotech business.”

Achim Treumann, scientific manager of NEPAF says: “Our aim at NEPAF is to use leading edge technology to provide solutions for real world biochemical problems. Our ability to help customers with the design tools will open up proteomics to a wide audience in academic and commercial research. The level of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com

K E Y I N D U S T RY B O D I E S W W W . C E L S G R O U P. C O M 1 4 7

A B

P R O T E O MABHI IC S F ofUBritish TU R E Industries Association Healthcare OF BIOTECHNOLOGY

C D

ADDRESS: 111 Westminster Bridge Road London POSTCODE: SE1 7HR WEB: www.abhi.org.uk

E

EMAIL: enquiries@abhi.org.uk TEL: 020 7960 4360 FAX: 020 7960 4361

F

The Association of British Healthcare Industries (ABHI) is the industry association for the medical technology sector in the UK. We represent companies whose output makes up for around eighty five percent of the industry’s total. Our membership includes some of the leading multinational businesses in the sector in the UK right the way through to small and medium sized enterprises (SMEs). Our aim is to promote the rapid adoption of medical technologies to ensure optimum patient outcomes throughout the UK and in key global markets.

G ABPI (Association of the British Pharamceutical Industry)

H I J K L M N O P Q R S T U V W X Y Z

ADDRESS: 12 Whitehall London POSTCODE: SW1A 2DY WEB: www.abpi.org.uk TEL: 0708 904333 FAX: 0207 7471414

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

The Association of the British Pharmaceutical Industry (ABPI) is the trade association for more than 90 companies in the UK producing prescription medicines for human use. Its member companies research, develop, manufacture and supply more than 80 per cent of the medicines prescribed through the National Health Service (NHS).

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit healthy from those in a ABPIcell Scotland diseased cell, you will see some small but vital In the traditional approach a single protein or differences. These different proteins may just

ADDRESS: Third Floor East a small number of proteins are separated out be a symptom of the disease, in which case Crichton House from all other proteins in 4the cell or organism they could help diagnose the disease much Crichton’s Close Canongate and studied in great detail.

Although this earlier, and thus improve the prognosis for Edinburgh approach remains very valuable it misses out the patient, or the different proteins may be Scotland some important information.

Proteins do not the cause of the disease, in which case they EH8 8DT POSTCODE: ABPI Scotland the Scottish office of the of the British exist in isolation from each other, so although could act as targets againstiswhich new drugs OfAssociation course much of this wasPharmaceutical promised from www.abpi.org.uk/ Industry (ABPI) which is the trade association of the pharmaceutical industry WEB: removes studying pure proteins interference can be developed. the earliest days of proteomics, and it has which brings together companies in the United Kingdom producing prescription from other proteins TEL: it also0870 reduces a lot of the said the resultsresearch so far have 8904333 medicines, other organisations involvedtoinbe pharmaceutical andnot lived 5230491 development and those with an interest pharmaceutical FAX: 0131 complexity and interaction which is actually a upintothe expectations.

This industry is in part because operating in the UK. key part of how proteins work. the technology has had to catch up with the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers www.bbsrc.ac.uk/ human genome project allowed the genetic to discover more proteins, more accurately BBSRC (Biotechnology & Biological Sciences Research Council) ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Polaris House to map out all the proteins in any cell or handle the immensely large and complex data North Stargiven Avenue Swindon organism, at a given time.

Once you can do generated by this research has also increased this it enables you to trulyWiltshire understand how the exponentially over the decade, and finally, but POSTCODE: SN2 1UH chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect WEB: www.bbsrc.ac.uk BBSRC is one of 7 Research Councils that work together and as Research In a way, the genome is rather like a dictionary new techniques methodsCouncils to allow UK them (RCUK). It is funded from the Government’s Department for Business, Innovation TEL: 01793 413200 which contains a list of all the possible words to generate and interpret robust reliable data. and Skills (BIS).

FAX: 01793 413201 in a language, whereas the proteome is more current is £450M. It supports a total around 1600 scientists and like the individual books in that language, Since differentBBSRC’s cell types can budget be characterised In many waysofproteomics has finally caught 2000 research students in universities and institutes in the UK. these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 4 8 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

A

BIA (BioIndustry Association)

B

ADDRESS: 14/15 Belgrave Square London POSTCODE: SW1X 8PS

C

WEB: www.bioindustry.org

EMAIL: admin@bioindustry.org

The BIA exists to promote the human health benefits of new bioscience technologies, encouraging the commercial success of the bioscience industry by focusing on emerging enterprise and the related interests of companies with whom such enterprise trades.

TEL: 020 75657190 FAX: 020 75657191

The BIA supports member interests by lobbying Government and Parliament in the UK and Brussels, providing high quality information and business services, and attracting investment from both private and Government sources.

D E F G

BIA (BioIndustry Association) Scotland

H

ADDRESS: Crichton’s House 4 Crichton’s Close Edinburgh POSTCODE: EH8 8DT

I J

WEB: www.bioindustry.org

EMAIL: scotland@bioindustry.org TEL: 0131 5230498 FAX: 0131 5230491

Based in Midlothian and is run by the acting Director, Sarah Goulding. BIA Scotland represents the needs of the Scottish bioscience sector. The team at BIA Scotland organise various activities to ensure that members are able to communicate their views on the sector to investors, Scottish Enterprise and the Scottish Executive and Scottish Parliament

NEPAF (the North East Proteome Analysis Through Cels, NEPAF has a dedicated Facility) will work with a wide range of research team of six scientists, including experienced and development groups and healthcare practitioners in the field of proteomics. companies in the private and public sector in the UK and internationally and willbioProcess provide DrUK Glen(Knowledge Kemp , project manager, NEPAFNetwork) Transfer them with access to leading expertise and says: “The UK’s biotechnology sector is equipment for the study of proteins. growing and in order for this growth to art

ADDRESS: BioIndustry Association facilities that allow even the smallest of 14/15 Belgrave Square The facility will give clients access to expertise companies to carry out the research they London SW1X 8PS POSTCODE: in the use of proteomics for drug discovery, need. NEPAF’s goal is to support companies development and manufacture and in the carrying out significant and, in some cases, WEB: www.bioprocessuk.org diagnosis and monitoring of disease. ground-breaking research and development bioProcessUK is a Knowledge Transfer Network (KTN) dedicated to advancing using proteomics that will secure the EMAIL: bioprocessukadmin@ the UK biopharmaceutical bioprocessing sector. bioProcessUK was established to bioindustry.org The facility provides a range of services reputation of therecommendation North East as the4place implement of thetoBIGT report Bioscience 2015. bioProcessUK is

responsible for supporting the growth of this sector in the UK including protein extraction, using one of the do biotech business.”

020 7565 7143 TEL: first pressure cycling homogenisers in the UK, Achim Treumann, scientific manager of 020 7565 7191 FAX: protein separation using 2-D Polyacrylamide NEPAF says: “Our aim at NEPAF is to use Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including Biosciences six academic and commercial research. The level Knowledge Transfer Network different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable

ADDRESS: Administration Office (York) capabilities for biomarker discovery, signal results and our scientists’ communication IT Centre transduction pathway analysis,Park protein skills ensure that you will understand them. ” York Science Heslington expression analysis, protein identification, York quantification and characterisation.

For further information visit: POSTCODE: YO10 5DG www.nepaf.com Our Vision of the Biosciences KTN is to make the UK a global leader in converting bioscience knowledge into innovative agricultural, food and industrial bioscience www.biosciencektn.com WEB: With its main laboratory located on the products and processes for the benefit of businesses, the economy, the campus of Newcastle University and a environment and society.

TEL: 01904 561582 second laboratory located on the campus of Our Mission is to Connect and Catalyse by: Durham University, NEPAF is supported by the regional development agency One North • Driving knowledge transfer between the science base and industry East and the European Regional Development • Promoting networking and stimulating innovation key to our industry sectors • Providing a coherent voice for industry to inform government policy.

Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 4 9

A B

P R O T E O MBISI(Department C S FforUBusiness, T U Innovation R E & Skills) OF BIOTECHNOLOGY

C D E

ADDRESS: Ministerial Correspondence Unit Department for Business Innovation & Skills 1 Victoria Street London POSTCODE: SW1H 0ET

BIS central purpose is to help ensure business success in this increasingly competitive world and at a time when British business is facing tough challenges.

WEB: www.bis.gsi.gov.uk

EMAIL: enquiries@bis.gsi.gov.uk

BIS supports business and enterprise. We champion better regulation. We promote free and fair markets in the EU and globally. And we act as shareholder for the Government in economically significant businesses.

TEL: 020 7215 5000

F G Business & Enterprise North East

H I

J

WEB: www.businesslink.gov.uk

K

L M N O P Q R S T U V W X Y Z

ADDRESS: Business Link in the North East Spectrum 6 Spectrum Business Park Seaham Durham POSTCODE: SR7 7TT

EMAIL: enquiries@businesslink northeast.co.uk TEL: 0845 600 9 006

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

In the traditional approach a single protein or

ADDRESS: Quorum 16 a small number of proteins are separated out Quorum Business Park from all other proteins in Benton the cell Lane or organism Newcastle and studied in great detail.

Althoughupon this Tyne POSTCODE: NE12 8BX approach remains very valuable it misses out some important information.

Proteins do not WEB: www.cbsl-uk.com exist in isolation from each other, so although Mike Nicholds studying pureCONTACT: proteins removes interference

JOB ROLE: Managing Director from other proteins it also reduces a lot of the EMAIL: enquiries@cbsl-uk.com complexity and interaction which is actually a how proteins work. key part of TEL: 0191 2155025 FAX: 0191 2155125

Proteomics aims to redress this by embracing the complexity of a large number of different proteins in the same sample. Just as the human genome project allowed the genetic ‘plan’ of human beings to be deciphered, so proteomics, one day, aims to provide a means

ADDRESS: Quorum 16 to map out all the proteins in any Business given cellPark or Quorum Benton organism, at a given time.

Once Lane you can do upon Tyne this it enables you to trulyNewcastle understand how the POSTCODE: NE12 8BX chemical building blocks of life truly interact.

WEB: www.celsgroup.com

In a way, the genome is rather like a dictionary CONTACT: Mike Asher which contains a list of all the possible words

JOB ROLE: CEO in a language, whereas the proteome is more info@celsgroup.com like the individualEMAIL: books in that language, these do not contain all the words, only those TEL: 0191 2155025 needed to tell the story, way in which 0191the 2155125 FAX: and those words interact dictates how the story is shaped, but unlike a book, the proteome is not fixed in time either, it is constantly

1 5 0 C E L S H E A LT H C O N N E C T

Business & Enterprise North East delivers the Business Link service across the whole of the North East.

We provide the region’s businesses and those who wish to start-up in business with support that is credible, efficient, targeted and focussed - and which will deliver a measurable and effective impact for North East businesses.

changing as it ages and even in response to changes from outside and within.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, literally from cradle to grave.

What is more, since proteomics can be applied to any living organisms, it is increasingly being used in agricultural biotechnology to help develop better food crops and more efficient biofuels, and in microbiology to both fight microbes and to harness their amazing diversity.

For example if you could compare the proteins in a fit healthy CBSL cell from those in a diseased cell, you will see some small but vital differences. These different proteins may just be a symptom of the disease, in which case they could help diagnose the disease much earlier, and thus improve the prognosis for the patient, or the different proteins may be the cause of the disease, in which case they CBSL provides consultancy services to support start-up and existing companies, could act as targets against drugs Of course of this inwas promised from universities and which public new sector clients across the UK.much Specialists healthcare and life sciences, CBSL has an excellent track record of of delivering consultancy can be developed. the earliest days proteomics, and it has services to clients in the private and public based on the wealth to besector said the results so far haveofnot lived expertise in the commercialisation of life science and healthcare technology. up toon expectations.

This in part because With a strong team of consultants focussing the North East of is England and thecollective technology has had to upacross with Scotland, CBSL draws on over 100 years’ experience of catch working sectors including industry, academia and NHS Some in areas and the the theory. of of theinnovation equipment used for commercialisation, project evaluation, economic development, research and proteomics, such as high resolution mass technology transfer. spectrometers, have improved greatly over the last decade, and now allow researchers to discover more proteins, more accurately Cels and more quickly than ever before. The amount of computing power required to handle the immensely large and complex data generated by this research has also increased exponentially over the decade, and finally, but perhaps most importantly, the people working in the field have had to develop and perfect Cels plays a significant role in the delivery the region’sand plans in healthcare newoftechniques methods to allowand them life sciences to drive the growth of the overall healthcare economy in North East to generate and interpret robust reliable data.

England. The North East has a growing and dynamic industrial base that spans

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

Driving the business of life sciences

from multinational pharmaceutical companies to innovative spin-outs and startareas can suchbe ascharacterised oncology and regenerative medicine.

Cels ishas committed to Since differentups cellintypes In many ways proteomics finally caught developing scientific enterprise through the development and commercialisation by their own unique proteome fingerprint, up with itself, that is not to say there are no of new technology, innovations and the exploitation of new and emerging proteomics can be used to study how more challenges to overcome, but we are market opportunities

embryonic stem cells can develop into any one of many different cell types, or it can look at the changes that occur in cells as they age

now in a better position than ever before to finally reap the rewards of this young and exciting field of science.

A

EMEA (European Medicines Evaluation Agency)

B

ADDRESS: 7 Westferry Circus Canary Wharf London POSTCODE: E14 4HB

C

WEB: www.ema.europa.eu

EMAIL: info@ema.europa.eu TEL: 0207 4188400

The European Medicines Agency is a decentralised body of the European Union with headquarters in London. Its main responsibility is the protection and promotion of public and animal health, through the evaluation and supervision of medicines for human and veterinary use.

D E F G

EPSRC (Engineering and Physical Sciences Research Council)

ADDRESS: Polaris House North Star Avenue Swindon POSTCODE: SN2 1ET

I J

WEB: www.epsrc.ac.uk

EMAIL: infoline@epsrc.ac.uk TEL: 01793 444000

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

H

We are the main UK government agency for funding research and training in engineering and the physical sciences, investing more than £800 million a year in a broad range of subjects – from mathematics to materials science, and from information technology to structural engineering.

K L

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

M

Dr GlenHealthConnect Kemp , project manager, NEPAF says: “The UK’s biotechnology sector is growing and in order for this growth to art

ADDRESS: Quorum 16 facilities that allow even the smallest of Quorum Business Park The facility will give clients access to expertise companies to carry out the research they Benton Lane Newcastle Tyne in the use of proteomics for upon drug discovery, need. NEPAF’s goal is to support companies 8BX POSTCODE: development andNE12 manufacture and in the carrying out significant and, in some cases, be well, connected diagnosis and of disease. ground-breaking research and development www.bewellconnected.co.uk WEB:monitoring a network for professionals and organisations working in the using HealthConnect proteomics thatiswill secure the Michael Hutchins healthcare sciences are active in assistive technology, CONTACT: The facility provides a range of services reputation of the and NorthlifeEast as thesector. place Members to health informatics, medical devices, biotechnology and life sciences, health and

JOB ROLE: Network Manager including protein extraction, using one of the do biotech social business.” care, health and well being as well as their associated supply chains. first pressure cycling homogenisers in the UK, Achim Treumann, scientific manager of michael.hutchins@celsgroup.com EMAIL: Besays: well connected HealthConnect

protein separation using 2-D Polyacrylamide NEPAF “Our aim at- NEPAF is to use brings together healthcare and life sciences professionals and organisations to stimulate translational research, innovation, TEL: 0191 2155025 Gel Electrophoresis (2D-PAGE) and leading edge technology to provide solutions collaboration as well as commercial opportunities.

FAX: 0191 2155125 multi-dimensional liquid chromatography for real world biochemical problems. Our (MD-LC). Separated proteins can then be ability to help customers with the design tools investigated using a wide range of state of will open up proteomics to a wide audience in the art analytical techniques, including six academic and commercial research. The level HTA different mass spectrometers and a protein of validation of experimental data generated in arraying system. These instruments provide the NEPAF lab ensures that you obtain reliable

ADDRESS: Finlaison House capabilities for biomarker discovery, signal results and our scientists’ communication 15-17 Furnival Street transduction pathway analysis, protein skills ensure that you will understand them. ” London EC4A 1AB identification, POSTCODE: expression analysis, protein quantification and characterisation.

For further information visit: WEB: www.hta.gov.uk www.nepaf.com enquiries@hta.gov.uk We support public confidence by licensing and inspecting organisations that EMAIL: With its main laboratory located on the store and use human tissue for purposes such as research, patient treatment, campus of Newcastle University and a post-mortem examination, teaching and public exhibitions.

TEL: 020 7211 3400 second laboratory located on the campus of FAX: 020 7211 3430 We also give approval for organ and bone marrow donations from living people Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 5 1

A B

P R O T E O M I C S F Medilink U T UUKR E OF BIOTECHNOLOGY

C D

ADDRESS: 4 Greenfield Crescent Edgbaston Birmingham POSTCODE: B15 3BE

WEB: www.medilinkuk.co.uk

E

EMAIL: info@medilinkuk.com TEL: 0121 4525630 FAX: 0121 4542325

F

MHRA (Medicines and Healthcare Products Regulatory Authority)

H

J K L M N O P Q R S T U V W X Y Z

Medilink UK is committed to increasing economic activity in the life sciences sector within the UK, focusing on the SME businesses by clustering their activity and engaging with academia, public and private health providers, and larger industry.

Medilink UK is the umbrella organisation for several life science-focussed organisations, all of whom measure their activity against the phrase “how is this beneficial to industry”.

G

I

Medilink UK is the industry association for Life Science SMEs

ADDRESS: 10-2 Market Towers 1 Nine Elms Lane London POSTCODE: SW8 5NQ WEB: www.mhra.gov.uk

EMAIL: info@mhra.gsi.gov.uk TEL: 020 70842000 FAX: 020 70842353

The Medicines and Healthcare products Regulatory Agency (MHRA) is the government agency which is responsible for ensuring that medicines and medical devices work, and are acceptably safe.

No product is risk-free. Underpinning all our work lie robust and fact-based judgements to ensure that the benefits to patients and the public justify the risks.

to give us important insights in the ageing process as a whole. So there are scientific questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteins a fit healthy cell from those inCouncil) a What is more, since proteomics can MRC in(Medical Research diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural

ADDRESS: 20 Park Crescent a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food London from all other proteins in W1B the cell they could help diagnose the disease much crops and more efficient biofuels, and in 1ALor organism POSTCODE: and studied in great detail. Although this earlier, and thus improve the prognosis for microbiology to both fight microbes and to WEB: www.mrc.ac.uk approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity. some important EMAIL: information.

Proteins do not the cause of the disease, in which case they corporate@headoffice.mrc.ac.uk The Medical Research Council is a publicly-funded organisation dedicated exist in isolation from each other, so although could act as targets against which new drugs Of course much of this was promisedtofrom 0207 6365422 improving human health. We support research across the entire spectrum of TEL: removes studying pure proteins interference can be developed. the earliest days of proteomics, and it has medical sciences, in universities and hospitals, in our own units and institutes in the FAX: 0207 4366179 from other proteins it also reduces a lot of the to be said the results so far have not lived UK and in our units in Africa. complexity and interaction which is actually a up to expectations. This is in part because key part of how proteins work. the technology has had to catch up with the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately Nanocentral ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Centre for Process Innovation to map out all the proteins in any given cell or handle the immensely large and complex data Wilton Centre Wilton organism, at a given time.

Once you can do generated by this research has also increased this it enables you to trulyRedcar understand how the exponentially over the decade, and finally, but POSTCODE: TS10 4RF chemical building blocks of life truly interact. perhaps most importantly, the people working in the field have had to develop and perfect WEB: www.nanocentral.eu NanoCentral is driving the safe, beneficial profitable commercialisation In a way, the genome is rather like a dictionary newand techniques and methods to allowofthem nanomaterials. We are an alliance of organisations capable of providing you CONTACT: Steve Devine which contains a list of all the possible words to generate and interpret robust reliable data. access to a broad range of leading edge technologies, equipment and services. in a language, whereas proteome is more steve.devine@nanocentral.eu EMAIL: the uniquely provides existingInand potential manufacturers userscaught of individual books in that language, like the Since differentNanoCentral cell types can be characterised many ways proteomics has or finally nanomaterials single point access to an integrated and comprehensive set of TEL: 01642 442464 these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no nano-related capabilities needed to tell the story, and the way in which proteomics can be used to study how more challenges to overcome, but we are those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

1 5 2 C E L S H E A LT H C O N N E C T

changing as it ages and even in response to changes from outside and within.

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

NICE (National Institute for Health and Clinical Excellence)

B

ADDRESS: MidCity Place 71 High Holborn London POSTCODE: WC1V 6NA

C

WEB: www.nice.org.uk

A

EMAIL: nice@nice.org.uk

NICE produces guidance in three areas of health: public health - guidance on the promotion of good health and the prevention of ill health for those working in the NHS; local authorities and the wider public and voluntary sector health technologies and guidance on the use of new and existing medicines; treatments and procedures within the NHS clinical practice - guidance.

TEL: 0845 0037780 FAX: 0845 0037784

D E F G

National Institute for Health Research (NIHR)

WEB: www.nihr.ac.uk EMAIL: enquiries@nihr.ac.uk

H

ADDRESS: Room 132 Richmond House 79 Whitehall London POSTCODE: SW1A 2N

NEPAF (the North East Proteome Analysis Facility) will work with a wide range of research and development groups and healthcare companies in the private and public sector in the UK and internationally and will provide them with access to leading expertise and equipment for the study of proteins.

ADDRESS: School of Applied Sciences Northumbria University The facility will give clients access to expertise Ellison Building Ellison Place in the use of proteomics for drug discovery, upon Tyne development andNewcastle manufacture and in the POSTCODE: NE1 8ST

diagnosis and monitoring of disease.

WEB: www. northumbria.ac.uk

The facility provides a range of services EMAIL: as@northumbria.ac.uk including protein extraction, using one of the first pressure cycling in the UK, 0191homogenisers 2274721 TEL: 2273519 FAX: 0191 protein separation using 2-D Polyacrylamide Gel Electrophoresis (2D-PAGE) and multi-dimensional liquid chromatography (MD-LC). Separated proteins can then be investigated using a wide range of state of the art analytical techniques, including six different mass spectrometers and a protein arraying system. These instruments provide

ADDRESS: Stella House capabilities for biomarker discovery, signal Goldcrest Way transduction pathway analysis, protein Newburn Riverside Newcastle Tyne. expression analysis, protein upon identification, POSTCODE: NE15 8NY quantification and characterisation.

WEB: www.onenortheast.co.uk

With its main laboratory located on the enquiries@onenortheast.co.uk campus EMAIL: of Newcastle University and a

second laboratory located on the campus of 2296200 TEL: 0191 2296201 FAX: 0191 Durham University, NEPAF is supported by the regional development agency One North East and the European Regional Development Fund. In 2007 Cels secured £4 million to develop the facility, which is the only one of its kind in the North East of England.

I J The National Institute for Health Research is now established as a part of the Government’s strategy, ‘Best Research for Best Health’. Together we are committed to establishing the NHS as an internationally recognised centre of research excellence through supporting outstanding individuals, working in world-class facilities, conducting leading-edge research focused on the needs of patients and the public.

Through Cels, NEPAF has a dedicated team of six scientists, including experienced practitioners in the field of proteomics.

K L M

DrNorthumbria Glen Kemp , project manager, NEPAF University says: “The UK’s biotechnology sector is growing and in order for this growth to art facilities that allow even the smallest of companies to carry out the research they need. NEPAF’s goal is to support companies carrying out significant and, in some cases, Biosciences research encompasses a wide range of biology-based subjects which have ground-breaking and development thewill University usingdeveloped proteomicsas that secure has the grown and the science itself has moved on. A core understanding of life at the scientific level runs throughout our courses, from reputation of the Norththrough East asBiotechnology the place to and Biomedical Science, to medicine.

Applied Biology, do biotech business.”

School ofscientific Applied manager Sciences is AchimThe Treumann, ofa dynamic and innovative School that brings together research and teaching expertise in biological, biomedical, NEPAF says: “Our aim at NEPAF is to use disaster management, geography chemical, food and forensic sciences, leading edge technology management to provide solutions and environmental to focus on the study and advancement of world physical, biological, chemicalOur and societal processes that support the for real biochemical problems. sustainable well-being of the planet. ability to help customers with the design tools will open up proteomics to a wide audience in academic and commercial research. The level One North East of validation of experimental data generated in the NEPAF lab ensures that you obtain reliable results and our scientists’ communication skills ensure that you will understand them. ” For further information visit: www.nepaf.com One North East is the Regional Development Agency (RDA) covering North East England.

We are one of nine RDAs in England that were established to transform the English regions through sustainable economic development.

Our vision is a vibrant, self reliant, ambitious and outward looking region promoting the benefits of living, working and doing business here.

N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 5 3

A B

PROTEOMICS UTU R EUK) RCUKF (Research Councils OF BIOTECHNOLOGY

C D

ADDRESS: Polaris House North Star Avenue Swindon POSTCODE: SN2 1ET WEB: www. rcuk.ac.uk

E

EMAIL: info@rcuk.ac.uk

Research Councils UK (RCUK) is a strategic partnership between the seven UK Research Councils. RCUK was established in 2002 to enable the Councils to work together more effectively to enhance the overall impact and effectiveness of their research, training and innovation activities, contributing to the delivery of the Government’s objectives for science and innovation.

TEL: 01793 444420

F G RegeNer8

H I

J

WEB: www.regener8.ac.uk

K

L M N O P Q R S T U V W X Y Z

ADDRESS: Enterprise and Innovation Office Charles Thackrah Building University of Leeds 101 Clarendon Road Leeds POSTCODE: LS2 9LJ

EMAIL: info@regener8.ac.uk TEL: 0113 3930933

The term Proteomics was only coined around 14 years ago, making it a relatively new science. It was developed to address a key limitation in classical protein biochemistry.

regeNer8 is one of the five virtual research centres that have been established by N8 through the Northern Way initiative, to promote scientific, social and economic development in the North of England. The North of England is uniquely positioned in Europe as a centre of basic research excellence in regenerative medicine. A collaborative regional approach has the potential to add considerable value to this emergent sector. The N8 Centre for Translational Regenerative Medicine will accelerate the development of regenerative therapies and bring them through to changing as itclinic agesand andmarket. even inregeNer8, responseisto to give us important insights in the ageing hosted by the University of Leeds and managed by changes fromaoutside and within. process as a whole. So there are scientific partnership between BITECIC and CBSL.

questions proteomics can help us answer, For example if you could compare the literally from cradle to grave. proteins in a fit healthy cell from those in a (TSB) What is more, since proteomics can Technology Strategy Board diseased cell, you will see some small but vital be applied to any living organisms, it is In the traditional approach a single protein or differences. These different proteins may just increasingly being used in agricultural

ADDRESS: North Star House a small number of proteins are separated out be a symptom of the disease, in which case biotechnology to help develop better food North Star Avenue from all other proteins in Swindon the cell or organism they could help diagnose the disease much crops and more efficient biofuels, and in SN2Although 1UE and studiedPOSTCODE: in great detail. this earlier, and thus improve the prognosis for microbiology to both fight microbes and to approach remains very valuable it misses out the patient, or the different proteins may be harness their amazing diversity.

WEB: www.innovateuk.org some important information. Proteins do not the cause of the disease, in which case they enquiries@tsb.gov.uk The Technology Strategy Board innovation in many exist in isolation EMAIL: from each other, so although could act as targets against which new drugspromotes Of course much of thisways. was promised from pure proteins removes interference studying can be developed. the earliest days of proteomics, and it has As well as investing in programmes and projects, much of our work is in spreading TEL: 01793 442700 from other proteins it also reduces a lot of the to beopportunities said the results far have not lived knowledge, understanding policy, spotting andso bringing people together to solve problems or make new complexity and interaction which is actually a upadvances. to expectations. This is in part because key part of how proteins work. the technology has had to catch up with the theory. Some of the equipment used for Proteomics aims to redress this by embracing proteomics, such as high resolution mass the complexity of a large number of different spectrometers, have improved greatly over proteins in the same sample. Just as the the last decade, and now allow researchers human genome project allowed the genetic to discover more proteins, more accurately UK Trade & Investment ‘plan’ of human beings to be deciphered, so and more quickly than ever before. The proteomics, one day, aims to provide a means amount of computing power required to

ADDRESS: Regional International to map out all the proteins in any given cell or handle the immensely large and complex data Trade Office Spectrum 6 can do organism, at a given time.

Once you generated by this research has also increased Business this it enables you to trulySpectrum understand how Park the exponentially over the decade, and finally, but Seaham chemical building blocks of life truly interact. perhaps most importantly, the people working SR7 7TT POSTCODE: in the field have had to develop and perfect www.uktradeinvest.gov.uk UK Trade & Investment supports companies in the Northand Eastmethods that wanttotoallow trade WEB:is rather In a way, the genome like a dictionary new techniques them and invest overseas. If you are a business based in the North East, call your which contains a list of all the possible words to generate and interpret robust reliable data. local International Trade Team to find out how you can access our full range of CONTACT: Keith Stockdale in a language, whereas proteome Trade is more International Adviser services to help you grow your international business.

JOB ROLE: the like the individual books in that language, Since different cell types can be characterised In many ways proteomics has finally caught EMAIL: enquiries@ukti.rito.co.uk these do not contain all the words, only those by their own unique proteome fingerprint, up with itself, that is not to say there are no

needed to tell the story, way in which proteomics can be used to study how more challenges to overcome, but we are 0845the 0505054 TEL: and those words interact dictates how the story embryonic stem cells can develop into any now in a better position than ever before to is shaped, but unlike a book, the proteome one of many different cell types, or it can look finally reap the rewards of this young and is not fixed in time either, it is constantly at the changes that occur in cells as they age exciting field of science.

1 5 4 C E L S H E A LT H C O N N E C T

“The people working in the field have had to develop and perfect new techniques and methods to allow them to generate”

UKCRN (UK Clinical Research Network)

ADDRESS: Coordinating Centre (NIHR CRN CC) Fairbairn House 71 - 75 Clarendon Road Leeds POSTCODE: LS2 9PH WEB: www.ukcrn.org.uk

A

EMAIL: crncc.info@nihr.ac.uk TEL: 0113 343 2314

B C The National Institute for Health Research Clinical Research Network Coordinating Centre (NIHR CRN CC) supports clinical research and helps to facilitate the conduct of trials and other well-designed studies within the NHS. The NIHR Clinical Research Network (NIHR CRN) in England is one of the four networks that comprise the UK Clinical Research Network (UKCRN).

D E F G H I J K L M N O P Q R S T U V W X Y Z

W W W . C E L S G R O U P. C O M 1 5 5

AAF International Ltd Supply Chain ABHI Association of British Healthcare Industries Key Industry Bodies ABPI (Association of the British Pharamceutical Industry) Key Industry Bodies ABPI Scotland Key Industry Bodies Aesica Pharmaceuticals Ltd Supply Chain Alcan Packaging Cramlington Ltd Supply Chain Alcyomics Ltd Biotechnology & Life Sciences Altonaids Mobility Ltd Assistive Technology Amtech Rapid Prototyping Ltd Supply Chain Analox Ltd Medical Devices ANP (N.E) Ltd Supply Chain Apollo Medical Systems Ltd Health Informatics Applied Imaging International Ltd Biotechnology & Life Sciences Aquajoy Bathlifts Ltd Assistive Technology Ascari Ltd Health Informatics Avecia Biologics Ltd Biotechnology & Life Sciences BBSRC (Biotechnology & Biological Sciences Research Council) Key Industry Bodies BIA (BioIndustry Association) Key Industry Bodies BIA Scotland Key Industry Bodies BioInnovel Ltd Biotechnology & Life Sciences bioProcess UK (Knowledge Transfer Network) Key Industry Bodies Biosciences Knowledge Transfer Network Key Industry Bodies BioSignatures Health Informatics Biotoolomics Ltd Biotechnology & Life Sciences BioTransformations Ltd Biotechnology & Life Sciences BIS (Dept. for Business Innovation & Skills Key Industry Bodies Bolton Bros Ltd Assistive Technology Brewin Dolphin Associates British Red Cross Associates Business & Enterprise North East Key Industry Bodies C2MUK Ltd Supply Chain Cambridge Research Biochemicals ltd Biotechnology & Life Sciences Captivu Ltd Associates Care-ability Healthcare Assistive Technology Carina VT Ltd Medical Devices CBSL Associates CBSL Biotechnology & Life Sciences CBSL Key Industry Bodies CDx ltd Medical Devices Cels Key Industry Bodies Centre For Design Research Supply Chain Centre for Rehabilitiation & Engineering Studies (CREST) Assistive Technology Chase Park Health & Social Care Chemispec Supply Chain Chemviron Carbon Cloth Division Medical Devices Christison Particle Technologies Ltd Medical Devices Cicada Communications Ltd Associates City Hospitals Sunderland NHS Foundation Trust NHS Clinical Clarity Health Informatics Classic Industries Europe Ltd Supply Chain Clicksquared Associates Clinical Ageing Research Unit (CARU) NHS Clinical Complement Genomics Ltd Biotechnology & Life Sciences Connect for Care Health & Social Care Connect Physical Health Centres Ltd Health & Social Care Connor Solutions Supply Chain Cord8 Ltd Biotechnology & Life Sciences Counted4 CIC Health & Social Care County Durham and Darlington NHS Foundation Trust NHS Clinical County Durham Development Co (CDDC) Associates County Durham Primary Care Trust (NHS County Durham) NHS Clinical Creative Gene Technology Ltd Biotechnology & Life Sciences CREST - Centre for Rehabilitation and Engineering Studies NHS Clinical Cundall Supply Chain

1 5 6 C E L S H E A LT H C O N N E C T

136 148 148 148 136 136 90 84 136 128 137 116 90 84 116 90 148 149 149 90 149 149 116 91 91 150 84 72 72 150 137 91 72 84 128 72 91 150 128 150 137 85 122 137 128 129 73 102 116 138 73 102 92 122 122 138 92 122 102 73 102 92 103 138

Daista Software Ltd Health Informatics Darlington Primary Care Trust (NHS Darlington) NHS Clinical Datatrial Health Informatics Dementia Care Partnership Health & Social Care Demuris Ltd Biotechnology & Life Sciences Design Right Solutions Supply Chain Disability Fitness Assistive Technology Disability North Associates Durham University Supply Chain e-Therapeutics plc Biotechnology & Life Sciences e3Design Ltd Supply Chain Easibathe Ltd Assistive Technology Eden Cottage Care Home Health & Social Care Electrochemical Sensor Techology (EST) Ltd Medical Devices Embryonyx Ltd Supply Chain EMEA (European Medicines Evaluation Agency) Key Industry Bodies Empatec Reglatory Services Supply Chain Enhancing Practice and Innovation Centre for Care (EPICC) NHS Clinical Enterprise Europe Network – North East England Associates Epigem Ltd Biotechnology & Life Sciences ePitope Informatics Ltd Health Informatics EPSRC (Engineering and Physical Sciences Research Council) Key Industry Bodies Femeda Ltd Medical Devices Finance Tree Associates Frame Kirkland Associates Gateshead Health NHS Foundation Trust NHS Clinical Gateshead Primary Care Trust NHS Clinical Geneius Laboratories Ltd Biotechnology & Life Sciences Genesis Genomics Ltd Biotechnology & Life Sciences Get More Time Associates GlaxoSmithKline Biotechnology & Life Sciences Grant Thornton Associates Harlow Printing Ltd Health Informatics Hart Biologicals Ltd Medical Devices Hartlepool PCT (NHS Hartlepool) NHS Clinical HB Innovations Medical Devices Healthclubtv Health & Social Care HealthConnect Key Industry Bodies Helena Biosciences Europe Biotechnology & Life Sciences High Force Research Ltd Biotechnology & Life Sciences Honeyman Group Ltd Supply Chain Horizonworks Marketing Ltd Associates HTA Key Industry Bodies Huntleigh Healthcare Ltd Medical Devices I2I Wheelchairs Assistive Technology IDEC Validation Ltd Supply Chain Ignition Sales Ltd Associates Immunodiagnostic Systems Holdings plc Medical Devices Inex - Innovation In Nanotechnology Exploitation Supply Chain Institute for Cell and Molecular Biosciences NHS Clinical Institute of Human Genetics NHS Clinical Intertek MSG Supply Chain Intrahealth Ltd Health Informatics Ithaka Life Sciences Associates Ithaka Life Sciences Supply Chain James Cook University Hospital NHS Clinical Kinneir Dufort Supply Chain Kite Innovation (Europe) Ltd Associates Knowledge House Supply Chain Kromek t/a Durham Scientific Crystals Ltd Biotechnology & Life Sciences Leica Biosystems Newcastle Ltd Medical Devices Lift Able Ltd Assistive Technology Litmus Images UK Ltd Associates Lyddallan Consultancy Ltd Supply Chain Lyddallan Consultancy Ltd Associates Magnetic Resonance Centre (MRC) NHS Clinical

117 103 117 123 92 138 85 73 139 93 139 85 123 129 139 151 139 103 74 93 117 151 129 74 74 104 104 93 93 74 94 75 117 129 104 130 123 151 94 94 140 75 151 130 85 140 75 130 140 104 105 140 118 75 141 105 141 76 141 94 130 86 76 141 76 105

Members by Category Marketwise Strategies Ltd Associates Marks & Clerk Associates MCB Associates Supply Chain Medilink UK Key Industry Bodies MediTek Assistive Technology MHRA (Medicines and Healthcare Products Regulatory Authority) Key Industry Bodies Micro-Tek Systems Ltd Supply Chain Middlesborough Council Assistive Technology Middlesbrough PCT NHS Clinical Millipore UK Ltd Biotechnology & Life Sciences MRC( Medical Research Council) Key Industry Bodies MSD Biotechnology & Life Sciences Murgitroyd & Company Associates My Sports Clinic Health & Social Care nano-porous solutions Ltd Supply Chain Nanocentral Key Industry Bodies Neecom Ltd Assistive Technology NEPAF Biotechnology & Life Sciences NETPark Associates Neural Pathways (UK) Ltd Health & Social Care Newcastle Biomedicine NHS Clinical Newcastle Clinical Trials Unit (NCTU) NHS Clinical Newcastle Diabetes Centre NHS Clinical Newcastle Fertility Centre NHS Clinical Newcastle NIHR Clinical Research Facility (CRF) NHS Clinical Newcastle Primary Care Trust NHS Clinical Newcastle University Institute For Ageing And Health Biotechnology & Life Sciences Newcastle upon Tyne Hospitals NHS Foundation Trust NHS Clinical NewGene Ltd NHS Clinical NHS Direct NHS Clinical NHS Innovations North Associates NICE, National Institute for Health and Clinical Excellence Key Industry Bodies NIHR, National Institute for Health Research�

Key Industry Bodies Nonlinear Dynamics Ltd Health Informatics North East Ambualnce Service NHS Trust NHS Clinical North East Better Health at Work NHS Clinical North East Finance Associates North East Public Health Observatory Health Informatics North East Public Health Observatory NHS Clinical North East Strategic Health Authority NHS Clinical North Tees and Hartlepool NHS Foundation Trust NHS Clinical North Tees Primary care Trust NHS Clinical North Tyneside Primary Care Trust NHS Clinical Northern Elevator Ltd Supply Chain Northern Recruitment Group plc Associates NorthGene Ltd Biotechnology & Life Sciences Northumberland Care Trust NHS Clinical Northumberland, Tyne & Wear NHS Foundation Trust NHS Clinical Northumbria Healthcare NHS Foundation Trust NHS Clinical Northumbria University Key Industry Bodies NPE Ltd Supply Chain Nzomics Biocatalysis Biotechnology & Life Sciences Octo Product Development Ltd Supply Chain Omega North East Ltd Supply Chain OmniRead Group Limted Health & Social Care One North East Key Industry Bodies Onyx Scientific Ltd Biotechnology & Life Sciences Opsol Uk Ltd Supply Chain Orla Protein Technologies Ltd Biotechnology & Life Sciences Outmark Associates Paladin Consultants Ltd Supply Chain Paragon Rapid Technologies Supply Chain Parker Domnick Hunter Medical Devices Peacocks Medical Group Medical Devices

76 77 142 152 86 152 142 86 105 95 152 95 77 123 142 152 86 95 77 124 106 106 106 103 107 107 95 107 106 107 77 153 153 118 108 108 78 118 108 108 109 109 109 142 78 96 109 110 110 153 143 96 143 143 124 153 96 143 96 78 144 144 131 131

Peerless Systems Ltd Supply Chain Piramal Healthcare UK Ltd Biotechnology & Life Sciences Pitman Training - Middlesborough Associates Pitman Training - Newcastle Associates Positron Emission Tomography (PET) Centre NHS Clinical PowerTrial Ltd Health Informatics Premier Healthcare & Hygiene Ltd Medical Devices Procter & Gamble Biotechnology & Life Sciences Public Knowledge Ltd Associates Quantum Specials Ltd Biotechnology & Life Sciences RCID Supply Chain RCUK (Research Councils UK) Key Industry Bodies Redcar & Cleveland PCT NHS Clinical RegeNer8 Key Industry Bodies Regional Medical Physics Health & Social Care Reinnervate Ltd Biotechnology & Life Sciences Rigel Medical Medical Devices RMT Accountants & Business Advisors Associates Rocket Medical Plc Medical Devices Sam Hamilton Medical Writing Services Ltd Associates SCHIN Ltd Health Informatics SCM Pharma Biotechnology & Life Sciences Selective Antibodies Ltd Biotechnology & Life Sciences SensaPharm Ltd Biotechnology & Life Sciences Shasun Pharma Solutions Ltd Supply Chain Signalway Antibodies Medical Devices Sintons LLP Associates Sir Bobby Robson Cancer Trials Research Centre NHS Clinical SJB Associates Health & Social Care South Tees Hospitals NHS Foundation Trust NHS Clinical South Tees Hospitals NHS Trust Clinical Research Facility NHS Clinical South Tyneside NHS Foundation Trust NHS Clinical South Tyneside Primary Care Trust NHS Clinical Step Ahead Research Supply Chain Strategic Property Solutions Assistive Technology Sue Clark Health & Fitness Health & Social Care Sunderland Teaching Primary Care Trust NHS Clinical Surreal Creative Associates Tappa Products ltd Assistive Technology Tees, Esk and Wear Valleys NHS Foundation Trust NHS Clinical Teesside University Associates The Outdoor Fitness Company Health & Social Care The Specials Laboratory Biotechnology & Life Sciences The You Company Medical Devices Thermal Compliance Ltd Supply Chain Thermo Fisher Scientific Medical Devices think M. Ltd Associates Tipple Associates Ltd Associates TrackaPhone Ltd Assistive Technology Technology Strategy Board Key Industry Bodies Tynetec Assistive Technology UK Haptics Health Informatics UK Trade & Investment Associates UK Trade & Investment Key Industry Bodies UKCRN (UK Clinical Research Network) Key Industry Bodies Urban River Associates VH Bio Ltd Biotechnology & Life Sciences Viratom Ltd Biotechnology & Life Sciences Vision For Change Health & Social Care Visitech International Medical Devices Walker Filtration Supply Chain Walker Graham Pharma Consulting Ltd Associates WH Partnership Supply Chain Wilson Horne Immunotherapy Centre NHS Clinical Wood Holmes Associates Yellow Road Associates

144 97 78 79 110 118 131 97 79 97 144 154 110 154 124 97 131 79 132 79 119 98 98 98 145 132 80 111 124 111 111 111 112 145 87 125 112 80 87 112 80 125 98 132 145 132 80 81 87 154 87 119 81 154 155 81 99 99 125 133 145 81 146 112 82 82

W W W . C E L S G R O U P. C O M 1 5 7

Advertisers Index

BIA 010

NETPark 062

BioInnovel Ltd 066

NewGene Ltd 056

Cambridge Research Biochemicals 022

Newcastle Science City 042

CDDC 065

Newcastle University Medical School 038

Cels 033

Northern Recruitment Group PLC 058

ChemiSpec 058

OmniRead Group 113

Distinctive Group 012 & 134

One North East 034

Durham University 060

Pall Corporation 053

Electrochemical Sensor Technology 059

Paragon Rapid Technologies 045

Enterprise Europe Network NE 004

Parker Dommnick Hunter 059

Epigem Ltd 047

Piramal Healthcare 051

GlaxoSmithKline 056

Rigel Medical 050

Hargreaves Elsworth 041

SJB Associates 088

Harrison Goodard Foote 058

SMRS 036

Hart Biologicals 054 & 159

STEPS 068

Helena Biosciences Europe 002

Tissue Solutions 058

Horizonworks 059

Tyntec 040

Institute for Ageing and Health 037

UK Trade and Investment 048

Marks and Clerk 021

University of Sunderland 120

McDaniel & Co. 044

Vetspeed UK 057

Medilink WM 036

Walker Graham Pharma Consulting 070

Nanocentral 126 & 160

Watson Burton LLP 057

National Skills Academy Process Industry 052

WH Partnership 046

NEPAF 016

Wilton Centre 114

NEPIC 017

1 5 8 C E L S H E A LT H C O N N E C T

The Positive Choice

+

for all your specialised haemostasis product requirements Founded in 2002, Hart Biologicals Ltd. is based in Hartlepool in North-East England.

The Hartlepool facility is engaged in the research, development manufacture and marketing of a range of in vitro diagnostic products for use in the detection, prevention and monitoring of a number of medical conditions related to haemostasis and platelet function.

Hart Biologicals products are based upon whole blood or blood plasma clotting technology or whole blood and platelet rich plasma platelet aggregation and platelet function test principles, technologies available in almost all pathology laboratories world-wide.

Hart Biologicals expertise, strong quality system, solid

infrastructure, expert and dedicated staff and state of the art manufacturing facilities have attracted partners ranging from small start up companies and Universities to large multinational Corporations. As a small company, Hart Biologicals can respond quickly to the needs of our partners and dedicate the best minds to their projects. Hart Biologicals provides contract services including Product Development, Regulatory Submission, Manufacturing, Customer Service, Sales, Marketing and Global Product Distribution Hart Biologicals is committed, through the companies vision and capabilities, to providing innovative and quality medical products to meet the needs of the ever changing healthcare field in a highly regulated industry environment.

Hart Biologicals Ltd 2 Rivergreen Business Centre Queens Meadow Hartlepool TS25 2DL

www.hartbio.com