Aggen dh cv

CURRICULUM VITAE Name:

David Henry Aggen

Address:

1101 University Avenue, 2S. Rochester Hills, MI 48307

Email:

daggen@med.wayne.edu

EDUCATION 2013 -

Resident Internal Medicine – Wayne State University School of Medicine Program PGY-2 Chief Internal Medicine Resident, Crittenton Hospital, Rochester, MI Expected Date of Completion: June 2016

2013

M.D.

University of Illinois College of Medicine at Urbana-Champaign

2010

Ph.D.

University of Illinois at Urbana-Champaign, Urbana, IL Molecular and Cellular Biology: Department of Biochemistry Advisor: David M. Kranz, Ph.D., Philip A. Sharp Professor of Biochemistry Dissertation: “Engineering Human Single-Chain T Cell Receptors” Developed murine and human chimeric antigen receptors and single-chain T cell receptors specific for viral and tumor antigens for adoptive T cell immunotherapy.

2005

B.A.

Illinois Wesleyan University, Bloomington, IL Department of Biology, Department of Chemistry Senior Thesis Advisors: David Bollivar, Ph.D., Ram Mohan, Ph.D

2004

Mayo Clinic College of Medicine Rochester, MN. Summer Undergraduate Research Fellow Department of Nephrology, Department of Biochemistry Advisor: Rajiv Kumar, M.D. Studied effects of phosphatonins, proteins that cause renal phosphate wasting in vitro and in vivo.

RESEARCH EXPERIENCE GRANTS, FELLOWSHIPS, AND PATENTS: 2012-2013 2012

Dr. David and Nancy Morse Scholarship, University of Illinois College of Medicine at Urbana-Champaign David M. Kranz and David H. Aggen “Human Single-Chain T Cell Receptors” Patent International Filing Date 2010, US Filing 2012 The Board of Trustees of the University of Illinois at Urbana-Champaign 1

2009-2010

Research Assistantship – NIH program project grant to Hans Schreiber and David M. Kranz

2007-2009

University of Illinois Cell and Molecular Biology Training Grant Competitive NIH Training Award

2006-2007 2006

National Institutes of Health (Stipend, Research Support, Travel Support) Research Assistantship – McDonnell Foundation Grant to David M. Kranz Hazel I. Craig Fellowship, University of Illinois College of Medicine at UrbanaChampaign

PUBLICATIONS 1. Stone, JD, Harris, DT, Soto, CM, Chervin, AS, Aggen, DH, Roy, EJ, Kranz, DM. A Novel T Cell Receptor Single-Chain Signaling Complex Mediates Antigen-Specific T Cell Activity and Tumor Control, Cancer Immunology Immunotherapy, 2014 Nov; 63(11):1163-1176.

2. Schmitt, TM, Aggen, DH, Stromnes, IM, Dossett, ML, Richman, SA, Kranz, DM, Greenberg, PD. Enhanced-Affinity Murine TCRs for Tumor/Self-Antigens Can Be Safe in Gene Therapy Despite Surpassing the Threshold for Thymic Selection, Blood, 2013 July;122(3):348-56.

3. Stone, JD, Aggen, DH, Schietinger, A, Schreiber, H, Kranz, DM. A Sensitivity Scale for Targeting T Cells with Chimeric Antigen Receptors (CAR) and Bispecific T Cell Engagers (BiTE), Oncoimmunology, 2012 Sept;1(6).

4. Stone, JD, Chervin, AS, Aggen, DH, T cell receptor engineering. Methods Enzymol. 2012;5-3:189-222.

5. Aggen, DH, Chervin, AS, Stone, JD, Engels, B, Piepenbrink, KH, Baker, BM, Schmitt, TM, Greenberg, PD, Schreiber, H, Kranz, DM. Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains. Gene Therapy. 2012 Apr:19(4):365-74.

6. Stone, JD, Aggen, DH, Chervin, AS, Narayanan, S, Schmitt, TM, Greenberg, PD, Kranz, DM. Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8. J Immunol. 2011 May 1;186(9):5193-200.

7. Aggen, DH, Chervin, AS, Insaidoo, FK, Piepenbrink, KH, Baker, BM, Kranz, DM. Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.

Protein Eng Des Sel. 2011 Apr;24(4):361-72..

8. Richman, SA, Aggen, DH, Dossett, ML, Donermeyer, DL, Allen, PM, Greenberg, PD, Kranz, DM. Structural features of T cell receptor variable regions that enhance domain stability and enable expression as a single-chain VαVβ fragments. Mol Immunol. 2009 Feb;46(5):902-16.

9. Chervin, AS, Aggen, DH, Raseman, JM., Kranz, DM. Engineering higher affinity T cell receptors using a T cell display system. J Immunol Methods. 2008 Dec;339(2):175-84.

10. Aggen, DH, Arnold, JN, Hayes, PD, Smoter, NM, Mohan, RS. Bismuth compounds in organic synthesis. Bismuth nitrate catalyzed chemoselective synthesis of acylals from aromatic aldehydes.

Tetrahedron. 2004 Jan;60: 3675-3679.

SEMINARS AND PODIUM PRESENTATIONS 2

2012

Chimeric Antigen Receptors and Bispecific T Cell Engagers for Cancer Immunotherapy.

College of Medicine Annual Research Symposium, Beckman Institute, UIUC, April 19th 2012.

2012

A Carcinoma-Like Cause of Upper Lobe Lung Cancer with Mediastinal Involvement.

College of Medicine Annual Research Symposium, Beckman Institute, UIUC, April 19th 2012.

2012

Single-Chain T Cell Receptors for Potential Cancer Immunotherapy Applications Cancer Community at Illinois Research Symposium, UIUC, April 6th, 2012.

2011

CD8:class I MHC Interactions Influence T Cell Activity Mediated by Chimeric Antigen Receptors. Seattle, WA, American Society for Gene and Cell Therapy, May 21st, 2011.

2010

Engineering Single-Chain T Cell Receptors for Cancer and Viral Immunotherapy .

Department of Biochemistry Graduate Student Seminar Series, UIUC, February 3rd, 2010.

2010

Engineering Single-Chain T Cell Receptors for Cancer and Viral Immunotherapy . Cell and Molecular Biology Training Grant Seminar Series, UIUC, April 7th, 2010.

2009

Engineering Single-Chain T Cell Receptors for Cancer Immunotherapy. Department of Biochemistry Graduate Student Seminar Series, UIUC, March 4th, 2009.

2008

Engineering Human Tumor Specific T Cell Receptors. Department of Biochemistry Graduate Student Seminar Series, UIUC, April 23rd, 2008.

2007

Engineering Human Tumor Specific TCRs for Improved Stability and Affinity. Cell and Molecular Biology Training Grant Seminar Series, UIUC, November 6th, 2007.

POSTER PRESENTATION ABSTRACTS 1. Retroperitoneal fibrosis presenting as septic gonadal vein thrombosis. Aggen, DH, Chhabra, J., Agarwal, P., Hublikar, S., Alcaraz, R., University of Illinois College of Medicine at UrbanaChampaign, April 19th, 2012, Champaign, IL. 2. Hiding in plain sight: An uncommon manifestation of a systemic inflammatory disorder.

Aggen, DH, Shah, S.M., Stephens, F.J., University of Illinois College of Medicine at UrbanaChampaign, April 19th, 2012, Champaign, IL. 3. Not always a muscle strain: watch out for a fatal cause! Aggen, DH, Muhammad, S., Adoni, S., University of Illinois College of Medicine at Urbana-Champaign Research Symposium, April 21, 2011, Champaign, IL. 4. Engineering high-affinity, single-chain T cell receptors for cancer adoptive therapy applications, 3

Aggen, DH, Chervin, AS, Stone, JD, Engels, B, Piepenbrink, K, Baker, BM, Schreiber, H, Kranz, DM., University of Illinois College of Medicine at Urbana-Champaign Research Symposium, April 2010, Champaign, IL. 5. Engineering high affinity single-chain T cell receptors for adoptive therapy applications, Aggen, DH, Chervin, AS, Stone, JD, Engels, B, Piepenbrink, K, Baker, BM, Kranz, DM., Keystone, CO. Keystone Symposium, “Molecular and Cellular Biology of Immune Escape in Cancer,” February 7th-12th, 2010.

6. Engineering T cell receptors for targeting immunotherapy applications, Aggen, DH, Chervin, AS, Richman, SA, Raseman, JM, Greenberg, PD, Kranz, DM., Cell and Molecular Biology Training Grant 22nd Research Symposium, October 2009, Urbana, IL. 7. Engineering T cell receptors for targeting immunotherapy. Aggen, DH, Chervin, AS, Richman, SA, Raseman, JM, Greenberg, PD, Kranz, DM., Biochemistry Department Annual Research Symposium, September 2009, Urbana, IL. 8. Engineering T cell receptors for targeting cancer immunotherapy. Aggen, DH, Chervin, AS, Richman, SA, Raseman, JM, Greenberg, PD, Kranz, DM., 29th Annual Medical Scholars Program Annual Retreat, August 2009, Urbana, IL. 9. Engineering T cell receptors for targeted immunotherapy. Aggen, DH, Chervin, AS, Bowerman, NA, Baker, BM, Greenberg, PD, Kranz, DM., University of Illinois College of Medicine at Urbana-Champaign Research Symposium, April 2009, Champaign, IL. 10. Engineering high affinity T cell receptors using a T cell display system. Aggen, DH, Chervin, AS, Raseman, JM, Kranz, DM., Cell and Molecular Biology Training Grant Research Symposium, October 2008, Urbana, IL. 11. In vitro engineered T cell receptors for potential cancer immunotherapy. Aggen, DH, Richman, SA, Raseman, JM, Greenberg, PD, Kranz, DM., Medical Scholars Program Annual Retreat, August 2008, Urbana, IL. 12. In vitro engineered T cell receptors for potential immunotherapy. Aggen, DH, Richman, SA, Raseman, JM, Greenberg, PD, Kranz, DM., University of Illinois College of Medicine at UrbanaChampaign Research Symposium, April 2008, Urbana, IL. 13. In vitro engineered T cell receptors for potential cancer immunotherapy. Aggen, DH, Richman, SA, Raseman, JM, Greenberg, PD, Kranz, DM., Cell and Molecular Biology Training Grant 20th Research Symposium, November 2007, Urbana, IL

AWARDS AND HONORS University of Illinois at Urbana-Champaign 2012 2nd Place Clinical Oral Vignette College of Medicine Annual Research Symposium “A Carcinoma-Like Cause of Upper Lobe Lung Cancer” 2012 2nd Place Clinical Research Poster Presentation College of Medicine Annual Research Symposium 4

“Retroperitoneal Fibrosis Presenting as Septic Gonadal Vein Thrombosis” Outstanding Oral Presentation

2012

Cancer Community at Illinois Research Symposium 2011

Biochemistry Trust of Urbana Award – Best Dissertation Department of Biochemistry, University of Illinois Urbana-Champaign

2011

Thomas E. Buetow Memorial Travel Award

2009

1st Place Basic Science Poster College of Medicine Annual Research Symposium “Engineering T cell receptors for targeted immunotherapy”

2007

Best Basic Science Poster Award College of Liberal Arts and Sciences, University of Illinois at Urbana-Champaign

Illinois Wesleyan University, Bloomington, IL 2005 Harold C. Hodges President’s Club Award in Natural Science and Mathematics Commencement honor given to one senior science student at IWU in the sciences 2005

Mortimer Award for Achievement in Chemistry Awarded to one senior for commitment to the Department of Chemistry

2005

Best Teaching Assistant, Department of Chemistry

2002

Chemistry Council of Illinois Scholarship

2001-04

Illinois Wesleyan Alumni Scholarship

TEACHING EXPERIENCE 2009-2011

Microbiology and Immunology Teaching Assistant (M1 Curriculum)

2007

University of Illinois College of Medicine at Urbana-Champaign Immunology Teaching Assistant (MCB 408) Department of Molecular and Cellular Biology University of Illinois at Urbana-Champaign

2004-2005

Facilitated weekly discussion sessions and developed curriculum and exams Organic Chemistry Teaching Assistant Department of Chemistry, Illinois Wesleyan University

COMMUNITY SERVICE 2012-13 Co-Director, Student Peer Mentor Program University of Illinois College of Medicine 2011-13 Chair, Man-2-Man Side-By-Side Prostate Cancer Support Group 2011 2006

American Cancer Society, Champaign, IL. Volunteer, Champaign Park District Student Member, Medical Scholars Program Planning Committee University of Illinois College of Medicine at Urbana-Champaign

2005-

Mentor to 5 undergraduate and 6 graduate research assistants 5

Laboratory of David M. Kranz 2004-05 Chemistry Demonstrations to Elementary School Students (IWU Chemistry Club)

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