November 2023 CU Pharmacology Newsletter

University of Colorado

Department of Pharmacology N O V EMBER 202 3 N E W S L E T T E R

a letter from

THE CHAIR Welcome to our first Pharmacology Department Newsletter! These newsletters will be sent out on a quarterly basis and will highlight recent accomplishments and successes in the Department, as well as our future goals. Since this is our first newsletter, I will summarize the many department accomplishments since I started as Chair of the department in mid 2022.

Since that time, our faculty have published 82 manuscripts, many in high profile journals that have had a significant impact in the broader scientific community. We continue to collaborate extensively, with 10 of those publications being shared amongst department members. This exceptional productivity is also seen in the 20 grants we have been awarded since mid 2022. All members of our department -- from administrative staff, to lab personnel, to faculty -- deserve credit for this accomplishment, as we know it takes a village to be successful in the grant arena. Furthermore, our trainees should get a special shout-out; 7 of them have received pre- or post-doctoral awards this year.

New department initiatives are underway, and I applaud our Wellness and DEI committees for all the work they have done this first year; this has made our department a more welcoming place for all. I also want to recognize the hard work of our recruitment committees and am excited that we will be welcoming Justin O’Hare to our faculty this coming summer. We are continuing to actively recruit moving forward.

Though we still have work to do on many fronts, I am confident that working together we will continue to make the Department of Pharmacology a top-tier department where we enjoy working together to do great science.

this issue: LETTE R F R O M T HE CHAIR PAGE 1 DEPAR T M E N T S C IENCE HIGHL I G H T S PAGE 2 & 3 STUDE N T R E S E A RCH DAY PAGE 4 CELEB R A T I O N S PAGE 5 DEI & W E L L N E S S UPDATES PAGE 6 NEW G R A N T S A W ARDED PAGE 7 PUBLI C A T I O N S PAGES 8 & 9 CAREE R O P P O R T UNITIES PAGE 1 0

As I reflect on my first year as Chair of the Department, I feel honored and humbled to work with such a great group of people.

Heide Ford, PhD Professor CU Medicine Endowed Chair

Department of Pharmacology

SCHOOL OF MEDICINE UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

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Scientific Highlights Pharmacology in the News

Paradigm-Shifting Discoveries on Mechanisms Could Unlock New Therapies for Alzheimer’s and Other Brain Diseases Department of Pharmacology Professor, Dr. Ulli Bayer, recently led his team in making a paradigm shifting discovery on the mechanisms required for learning and memory that could lead to new therapies for Alzheimer’s disease and potentially Down syndrome.

The study was published in August in the journal Nature and was featured in a press release in the CU Anschutz News.

For 30 years, researchers have believed that enzymatic CaMKII activity is required for a form of synaptic plasticity that is crucial for learning and memory (i.e. LTP, long-term potentiation). However, Dr. Bayer and his team found that LTP instead requires structural functions of CaMKII.

U l l i Bayer, PhD P r o f essor

This enables a new class of CaMKII inhibitors to alleviate Alzheimer’s-related impairments without interfering with LTP. Amyloid-beta (Abeta) plaques in the brain are a hallmark of Alzheimer’s disease. The researchers found one group of inhibitors that protected from the Abeta effects without impairing LTP. This could be potentially useful in treating a number of brain diseases without debilitating side effects.

The implications are that a certain class of CaMKII inhibitors could actually be used chronically to treat brain conditions including Alzheimer’s Disease. This is super novel, as it has previously been thought that any CaMKII activity inhibitor would block synaptic plasticity that underlies learning and memory so their chronic use would be counter-indicated,” said Dr. Ulli Bayer.

Dr. Bayer said if the inhibitors work in humans, they could provide additional benefit in conjunction with any current Alzheimer’s treatment strategies. The Bayer lab is now testing whether their predictions can be used for human therapy.

Department of Pharmacology

SCHOOL OF MEDICINE UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

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Scientific Highlights Pharmacology in the News

Dr. James Costello highlights the importance of data science and collaborative science What do you consider to be the importance of data science and collaborative science?

How have you managed to integrate data and collaborative science into your research?

The major challenges in biomedical research require many experts to collaborate and make decisions based on strong and reproducible data. So, the integration of collaborative and data sciences into the questions that we all study will provide the opportunity for greater scientific advancements and deep insights. We often try to reduce our questions into the most simplified systems so that we can control confounding variables and draw conclusions based on the results from our experiments. Science has come a long way with this approach and will continue in this manner into the future.

Collaborative and data sciences provide a different paradigm of addressing these questions and can be used to find patterns, identify novel relationships, and draw new insights as the questions we aim to address become more complex and the systems used try to account for more confounding variables.

There is an old adage, “If you want to go fast, go alone, If you want to go far, go together.”

Collaborative and data science approaches will hopefully facilitate the long journey to address the big challenges in biomedical research.

Our lab, and I would say all Pharmacology labs, integrate data and collaborative science into their research programs. From the collaborative science perspective, we have developed working relationships with collaborators with shared goals and mutually beneficial interactions. We try to partner with labs that complement our expertise and can address an aspect of the research question that we cannot. At least from our perspective, working with other investigators is both fun, can be highly productive, and we have benefited greatly from our collaborators in the Department.

What would you suggest to a junior faculty looking to collaborate within their research?

The scale may vary between labs, but the approaches we take to “make sense” of the data we generate is data science. Just as we use qPCR or western blots as a technique to address a specific question data mining, statistical models, and similar approaches are just more tools that we have in our toolkit to address the questions we study. With data science approaches, we are able not only to analyze our own data, but we can leverage publicly accessible datasets to generate novel hypotheses or to generate additional supporting results.

James Costello, PhD Associate Professor

There is no shortcut or secret to developing effective collaborative relationships. Ultimately, a collaboration is a mutual agreement between peers to work together to address a shared goal. This take time, effort, and commitment. Some factors do help collaborations start and develop. First, there must be a common goal, or a shared vision of the collaborative project that will result in a benefit to both individuals or the group. I think we all know this, but asking directly if there is a shared goal or what the shared goal is can shed light on the thinking of the two researchers. It is important to leverage your current resources and network. A relationship fostered by a mentor or colleague is a good place to start, particularly if you do not know the other person well. Start a collaboration with a small goal. There is nothing that keeps the relationship going like successfully generating new data that addresses the goals of both research groups. Being proactive is a necessity. It is much easier to let things pass and not get to items on our long list of items. If the relationship stagnates, it is less likely to succeed, hence generating small data wins helps. All of this is predicated on clear communications and expectations. For a junior person, the expectations are very important to make sure there is an equal contribution from both sides. Finally, nothing keeps the work together like money, so get a small pilot grant to start and build on that. Again, small wins. In the end, collaborations can come in many forms, and being clear on that form is a big part of being a good collaborator.

Department of Pharmacology

SCHOOL OF MEDICINE UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

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Student Research Day September 25, 2023

The Pharmacology PhD Program held its 11th Annual Student Research Day on September 25. This all-day event showcased research done by students and post-docs in the program and the Pharmacology Department through poster sessions and seminars.

Student Research Day was organized by students Maddy Rodriguez, Amber Stewart, and Lorena Alamillo and Program Administrator, Shanelle Felder (pictured above). Special thank you to the organizers for their hard work!

Student Research Day Award Winners BEST GRADUATE STUDENT TALK DILLON BOUTLON 6TH YEAR, CAINO LAB

BEST GRADUATE STUDENT POSTER SPENCER HALL

3RD YEAR, VERNERIS LAB & DAVILA LAB

BEST POSTDOC TALK SAMANTHA OLAH

POSTDOC, KENNEDY LAB

BEST POSTDOC POSTER KARTHIK SELVAM

POSTDOC, KUTATELADZE LAB

Department of Pharmacology

SCHOOL OF MEDICINE UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

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CELEBRATIONS Cheers!

The Department of Pharmacology Recently celebrated the retirement of Paula Hoffman, PhD. Dr. Hoffman has committed more than 30 years of service to the University of Colorado. She is known for her research related to the neurobiological effects of alcohol, where she has spent many years focusing on the neuroadaptive mechanisms that lead to either tolerance or withdrawal.

We thank Dr. Hoffman for her service and commitment to the University of Colorado and the Department of Pharmacology and wish her all the best in retirement!

Paula Hoffman, PhD Professor Emerita

Fall has been full of fun events for the Department of Pharmacology, including a department happy hour, a hot drink cart to celebrate the beginning of the school year, and Pharm Fall Fest 2023!

Department of Pharmacology

SCHOOL OF MEDICINE UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

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DEI & Wellness Updates

From the DEI & Wellness Committee Chairs

The Department of Pharmacology’s Diversity, Equity, and Inclusion and Wellness Committees were founded in July 2022. Both committees have aided in creating a sense of connection in a post-pandemic environment. They have decorated our walls and educated us in ways that we can improve our health, wellbeing, and potential. We can’t wait to see what the next fiscal year brings!

Diversity, Equity, and Inclusion (DEI) Committee Drs. Scott Cramer and Katherine Waugh founded the department’s DEI committee. Claire Gillette has replaced Dr. Waugh’s seat in fiscal year 2024. The DEI Committee is constituted

by Jason Aoto, Stephanie Baker, Lily Feldman, Sara Gookin, Tyler Martinez, and Kaitlynn O’Leary. Throughout the year, the committee crafted a vision and mission statement specific to our department. They added resources to the department’s DEI webpage, created a visual representation of important DEI terminology, and added a Teams channel for all members.

Their goal in the first year was to establish presence and ensure all voices were heard. The goals of fiscal year 2024 include intentional recruitment of faculty, post-docs, and students.

Scott Cramer, PhD Professor DEI Commi ttee Co- Chai r

Cl ai re Gi l l ette, PhD Post Doc DEI Commi ttee Co- Chai r

Wellness Committee The department’s Wellness committee was founded by Dr. Cecilia Caino and constituted by Mair Churchill, Moriah Denler, Moli Joshi, Austin Kovac, Emily Sullivan, and Amber Truitt. The committee kicked off the year with a costume contest at the first annual Fall lunch. They held a variety of events including a kindness campaign; Anschutz Faculty and Staff from the Mental Health Clinic presented a seminar on Stress, Anxiety, and Self Care; a photo contest; and a lunch celebration of culture and international heritage. The committee will continue to focus on the overall Occupational/Social wellness of the employees in our workplace.

Ceci l i a Cai no, PhD Associ ate Professor Wel l ness Commi ttee Chai r

Department of Pharmacology

SCHOOL OF MEDICINE UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

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New Grants Awarded July-November 2023

National Institutes of Health “Elucidating the role of EYA2 at centrosomes in glioblastoma stem sells” NIH NRSA F31 2 years awarded

Parkinson’s Foundation Postdoctoral Fellowship Award “A novel genetic toolkit to manipulate dopamine release and receptor trafficking” 2 years awarded Chelsie Kadgien, PhD Post Doc Kennedy Lab

Art Wolin, MS Pre-Doctoral Fellow H. Ford Lab

N a t i onal Institu t e s o f H e a l t h “A n ew approac h t o u n d e r s t a n d i n g c o g n i t i v e d i s a b i l i t i e s i n Down s y n d rome” N I H R21 2 y e ars awarde d

Won Chan Oh, PhD Assistant Professor

T h e Ludeman Ce n t e r ’ s E a r l y - C a r e e r F a c u l t y R e s e a r c h D e v e lopment A w a rds “D e f ining how ma t e r n a l c a n n ab i d i o l ( C B D ) c o n s u m p t i o n d u r ing p r e g nancy affe c t s f e m a l e o f f s p r i n g c o g n i t i o n a n d m e n t a l h ealth” 1 y e ar awarded

National Institutes of Health “APP as a mediator of amyloid beta effects on CaMKII synaptic functions” NIH NRSA F31 3 years awarded Matt Larsen Graduate Student Bayer Lab

Department of Pharmacology

SCHOOL OF MEDICINE UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

National Institutes of Health “Trisomy 21 Model Atlas” NIH MPI R24 4 years awarded

Matthew Galbraith, PhD Assistant Professor

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Publications

July-November 2023

Affan d i T , H a a s A , Ohm AM, Wright GM, Black J C , R eyl a n d M E . P K C ð regulates chromatin remodeling and D N A r e p a i r t h rough SIRT6. Mol Cancer Res. 2023 Oct 27. doi: 1 0 . 1 1 5 8 / 1 5 41-7786.MCR-23-0 493 .

Barco m b K , F o r d CP . A lte r a t i o n s i n n e urotransmitter c o-release in Parkinson's disease. E x p N e u r o l .

2023 O c t 4 : 1 1 4 5 62. doi: 1 0 . 1 0 1 6 / j . e x pneurol.2023.114562 .

Brown K , C h e w P Y, Ingersoll S, Esp inosa JR, Aguirre A, Espinoza A, We n J , A s t a t i k e K , Kutat e l a d z e TG , C oll e p a r d o - G u e v ara R, Ren X. Principles of assembly and regulation o f c o n d e n s a t e s o f P o l y c o m b r epre s s i v e c o m p lex 1 through phas e separation. Cell Rep. 2023 Sep 2 6 ; 4 2 ( 1 0 ) : 1 1 3 1 3 6 . doi: 10.10 1 6 / j . c e l r e p . 2023.113136 .

D'Ale s s a n d r o A , N ouraie SM, Zhang Y, Cendali F, Gamboni F, Reisz JA , Z h a n g X , Bart s c h K W , Galbr a i t h M D , E s p inosa JM , G ord e u k V R , G l a dwin MT. Metabolic signatures of cardiorenal dysfu n c t i o n i n p l asma from sickle cell patients as a function of ther a p e u t i c t r a n s f u s i o n a n d hydro x y u r e a t r e a t ment. Haematologica. 2023 Jul 13. doi: 1 0 . 3 3 2 4 / h a e m atol.2023.

Fridm a n V , S i l l a u S, Ritchie A, Bockhorst J, Coughlan C, Araya P, Esp i n o s a J M , S m i t h K , L a n g e E M , Lange L A , Ghor m l i L E , D r e w s KL, Zeit l e r P , R e u s c h JEB . P las m a n e u r o f i l ament light chain conce n t r a t i o n s a r e elevated in youth-onset type 2 diabetes and asso c i a t e d w i t h n e u r o p a t h y . J Perip h e r N e r v S y s t. 2023 Sep;28(3):460-470. doi: 1 0 . 1 1 1 1 / j n s . 12575 .

Hughe s C J , F i e l ds KM, Danis EP, H su JY, Neelakantan D, Vincent MY , G u s t a f s o n A L , O l i p h a n t M J , Sreek a n t h V , Zabe r e z h n y y V , Coste l l o J C , J edl i c k a P , Ford H L . S IX1 a n d E W S / FLI1 co-regulate a n anti- m e t a s t a t i c g ene network in Ewing Sarcoma. Nat Commun. 2023 J u l 1 9 ; 1 4 ( 1 ) : 4 3 5 7 . doi: 10.10 3 8 / s 4 1 4 6 7 - 023-39945-w .

Jain S , Yee A G , M aas J , G i e r o k S, Xu H, Stansil J, Eriksen J, Nelson A, Silm K, Ford C P , E dwa r d s R H .

Adapt o r P r o t e i n - 3 Produces Synaptic Vesicles that Release Phasic Do p a m i n e . b i o R x i v [ P r e p r i n t ] . 2 0 2 3 Aug 8 : 2 0 2 3 . 0 8 . 0 7.552338. doi: 1 0 . 1 1 0 1 / 2 0 23.08.07.552338 .

Kuma r S i n h a V , Zhang Y , X u L , C h e n Y W , Picaud S, Zand i a n M , B i s was S , F ili p p a k o p o u l o s P, Wang SP, Shi X , Kutat e l a d z e T G . H ist o n e H 4 K 1 6 ac Binding Functio n of the Triple PHD Finger Cassett e o f M L L 4 .

J Mol B i o l . 2 0 2 3 Jul 20:168212. doi: 1 0 . 1 0 1 6 / j . j m b.2023.168212 .

Laaja l a T D , S r e e k anth V , S oup i r A C , C r e e d JH, Halkola AS, Calboli FCF, Singaravelu K, Orman M V , Colin - L e i t z i n g e r C, Gerke T, Fridley BL, Tyekucheva S, Coste l l o J C . A ha r m o n i z e d r e source of i nteg r a t e d p r o s t a te cancer clinical, -omic, and signature features. Sci D a t a . 2 0 2 3 J u l 5 ; 1 0 ( 1 ) : 4 3 0 . doi: 10.10 3 8 / s 4 1 5 9 7 - 023-02335-4 .

Lloyd B A , H an Y , Roth R , Z han g B , Aoto J . N eur e x i n - 3 s u b s ynaptic densities are spatially distinct f r o m N e u r e x i n - 1 a nd essential for excitatory synapse nanoscale orga n i z a t i o n i n t h e h i p p o c a m p u s .

Nat C o m m u n . 2 0 2 3 Aug 5;14(1):47 06. doi: 1 0 . 1 0 3 8 / s 4 1467-023-40419-2 .

Ludwi g M P , Galbr a i t h M D , E dut h a n N P , H i l l AA, Clay MR, Tellez CM, Wilky BA, Elias A, Espin o s a J M , Sulli v a n K D . P r o t easome Inhibition Sensitizes Liposarcoma to MDM2 I n h i b i t i o n w i t h N u t l i n - 3 b y Activ a t i n g t h e A T F4/CHOP Stress Response Pathway. Cancer Res. 202 3 A u g 1 ; 8 3 ( 1 5 ) : 2 5 4 3 - 2 5 5 6 . doi: 10.11 5 8 / 0 0 0 8 - 5 4 72.CAN-22-3173 .

Ludwi g M P , Galbr a i t h M D , E dut h a n N P , H i l l AA, Clay MR, Tellez CM, Wilky BA, Elias A, Espin o s a J M , Sulli v a n K D . P r o t easome Inhibition Sensitizes Liposarcoma to MDM2 I n h i b i t i o n w i t h N u t l i n - 3 b y Activ a t i n g t h e A T F4/CHOP Stress Response Pathway. Cancer Res. 202 3 A u g 1 ; 8 3 ( 1 5 ) : 2 5 4 3 - 2 5 5 6 . doi: 10.11 5 8 / 0 0 0 8 - 5 4 72.CAN-22-3173

Department of Pharmacology

SCHOOL OF MEDICINE UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

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Publications

July-November 2023

Nguye n M C , W ang D , Klein B J , C hen Y , Kutat e l a d z e T G . D iff e r e n c e s a n d similarities in recognition of co-fa c t o r s b y T a f 14. Biochim Biophys Acta Gene Regul Mech. 2023 S e p ; 1 8 6 6 ( 3 ) : 1 9 4 9 6 1 . doi: 10.10 1 6 / j . b b a g r m.2023.194961 .

Ohm A M , A f f a n d i T, Reisz JA, Caino M C , D 'Al e s s a n d r o A , Reyland ME. Metabolic reprogramming contr i b u t e s t o r a dioprotection by protein kinase Cδ. J Biol Chem. 202 3 A u g 2 1 ; 2 9 9 ( 1 0 ) : 1 0 5 1 8 6 . doi: 10.10 1 6 / j . j b c . 2 0 2 3.105186 .

Olah S S , Karee m o D J , Bucht a W C , Sinne n B L , M i l l e r CN, Actor-Engel HS, Gookin SE, Winborn CS, Klein j a n M S , C r o s by KC, Aoto J, Smith KR, Kennedy MJ . A cut e r e o r g a n i z ation of postsynaptic GABAA r ecep t o r s r e v e a l s the functional impact of molecular nanoarchitectu r e a t i n h i b i t o r y s y n a p s e s . C e l l Rep. 2 0 2 3 O c t 3 1;42(11):113331. doi: 1 0 . 1 0 1 6 / j . c e lrep.2023.113331 .

Ramsay HJ, Gookin SE, Ramsey AM, Kareemo DJ, Crosby KC, Stich DG, Olah SS, Actor-Engel HS, Smith KR, Kennedy MJ. AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release. Front Mol Neurosci. 2023 Aug 3;16:1232795. doi:10.3389/fnmol.2023.1232795 .

Rosas R , A g u i l a r RR, Arslanovic N, Seck A, Smith DJ, Tyler JK, Churc h i l l M E A . A no v e l s i n g l e alphahelix D N A - b i n d i n g domain in CAF-1 promotes gene silencing and DNA d a m a g e s u r v i v a l t h r o u g h t etra s o m e - l e n g t h DNA selectivity a nd spacer function. Elife. 2023 Jul 1 1 ; 1 2 : e 8 3 5 3 8 . doi: 10.75 5 4 / e L i f e . 8 3538 .

Rumi a n N L , F r e u nd RK, Dell'Acqua ML, Coultrap SJ, Bayer KU . D ecr e a s e d n i t r o sylation of CaMKII cause s a g i n g - a s sociated impairme nts in memory and synaptic plasti c i t y i n m i c e . S c i S i g n a l . 2 0 2 3 J u l 25;16 ( 7 9 5 ) : e a d e 5892. doi: 1 0 . 1 1 2 6 / s c i s ignal.ade5892.

Smith A L , P a l D , Martinez-Rico R, Eiken AP, Durden DL, Kutat e l a d z e T G , E l-G a m a l D . P r e clinical activity of a n o v e l m u l t i - axis inhibitor in aggressive and indolent B-cell malig n a n c i e s . L e u k L y m p h o m a . 2 0 2 3 Sep 1 4 : 1 - 5 . doi: 1 0 . 1 0 8 0 / 1 0 428194.2023.2256 914.

Swens o n K S , Gome z W u l s c h n er LE, Hoelscher VM , F olt s L , K o r t h K M , Oh WC , B ate s E A . F e t a l canna b i d i o l ( C B D) exposure alters thermal pain sensitivity, problem-s o l v i n g , a n d p r e f r o n t a l c o r t e x excit a b i l i t y . M o l P sychiatry. 2023 Jul 11. doi: 1 0 . 1 0 3 8 / s 4 1380-023-02130-y .

Tence r A H , Y u Y , C a u s s e S Z , Campbell GR, Klein B J , X uan H , C a r t i e r J , Miles MA, Gaura v N , Z ado r o z n y j A, Holt T A , W en H , H a w k i n s CJ, Spector SA, D ubrez L, Shi X, Kutat e l a d z e T G . M ol e c u l a r b a s i s for nucle a r a c c u m u l ation and targetin g of the inhibitor of apoptosis BIRC 2 . N a t S t r u c t M o l B i o l . 2 0 2 3 Sep;3 0 ( 9 ) : 1 2 6 5 - 1274. doi: 1 0 . 1 0 3 8 / s 4 1594-023-01044-1 .

Thoma s S N , N i e m eyer BF, Jimenez -Valdes RJ, Kaiser AJ, Espin o s a J M , S ull i v a n K D , Goods p e e d A , Coste l l o J C , A lde r J K , C a ñ a s -Arranz R, García- Sastre A, Benam KH. Down syndro m e i s a s s o c i a t e d with a l t e r e d f r e q uency and functioning of tracheal multiciliated cells, a n d r e s p o n s e t o i n f l u e n z a v i r u s i nfec t i o n . i S c i e n ce. 2023 Jul 14;26(8):107361. doi:1 0 . 1 0 1 6 / j . i s c i.2023.107361 .

Tulli s , J E , L a r s e n ME, Rumian, NL, Freund RK, Boxer EE, Brown CN, C o u l t r a p S J , Schu l m a n H , Aoto J , Dell’ A c q u a M L , Bayer KU. LTP i n d u c t i o n b y structural rather than enzymatic functions of CaM K I I .

Natur e 6 2 1 , 1 4 6 –153 (2023). https : / / d o i . o r g / 1 0.1038/s41586-023-06465-y Wolin A R , V i n c e nt MY, Hotz T, Pur dy SC, Rosenbaum SR , Hughe s C J , H su J Y , O l i p h a n t MUJ, Armst r o n g B , W ess e l l s V , V a r ella-Garcia M, Galbr a i t h M D , P ier c e A , W a n g D, Venkataraman S, Danis E , Veo B , S e r k o v a N, Espi n o s a J M , G ust a f s o n D L , V ibhakar R, Ford H L . E YA2 T y r o s i n e P hosphatase I nhib i t i o n R e d u c e s MYC and Prevents Medulloblastoma Progression. N e u r o O n c o l . 2 0 2 3 J u l 24:no a d 1 2 8 . doi: 1 0 . 1 0 9 3 / n e uonc/noad128

Department of Pharmacology

SCHOOL OF MEDICINE UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

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Career Opportunities We’ re Hiring!

Department of Pharmacology Career Opportunities The Department of Pharmacology is actively recruiting for the following positions (all job postings are linked below):

Assistant/Associate Professor in Cancer Biology Pharmacology Assistant/Associate Professor in Neuroscience Pharmacology Post-Award/Payroll Program Manager Pharmacology Visit the Department of Pharmacology website to explore these opportunities further and submit an application.

Please feel free to share these open roles with your network!

Department of Pharmacology

SCHOOL OF MEDICINE UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS

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