Twenty first century primary care

Twenty-First Century Primary Care

Herbert W. Collins, M.D. F.A.A.F.P.

Preserving Survival Potential Herbert W. Collins, M.D. F.A.A.F.P.

Nothing fulfills the promise of diagnostic and therapeutic benefits of unmatched

quality as that offered through the exploitation of the anatomical fidelity of the distributions of neurological labyrinths of spinal nerves and the variables of the integrated physiology of the peripheral and central nervous system. These benefits are available with little effort, time, or expense, and are obtained without troublesome untoward consequences. These benefits makes it possible to place visceral insults to be within the specific visceral distributions of specific spinal nerves in real time and during this same moments one may fulfill the promise of convalescences that are not only safer but are also ones that are more comfortable, are of a shorter duration, and are associated with a lesser degree of disability.

In 1970 Epstein published articles recommending sublesional infiltration of a corticosteroid for the treatment of Herpes zoster. Observations during this treatment indicated that the benefits were due to the cutaneous impulses generated by the skin pricks of the treatment rather than that of the corticosteroid. The cutaneous impulses generated by these skin pricks provided instantaneous pain relief. Also some patients alluded to the relief of deep seated discomfort that was obtained through the neurophysiology of a single nerve. This deep seated relief hinted of the presence of specific visceral distributions. It was also noted that there was a marked increase in the sensitivity of the cutaneous distributions of the nerve that harbored the herpetic lesions. These observations furnished the impetus for twenty years of efforts directed at evaluating and defining the peripheral distributions and physiology of the neurological labyrinths of individual spinal nerves. These observations were conclude on my retirement from a solo family practice in 1990.

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hypotheses / theory

Insults alter local neurological impulses and they may also create structural compromises. Unless structural compromises represent significant disabilities they contribute little to the clinical picture. This leaves the clinical picture to be primarily the expressions of neurophysiology. These expressions are generated by the brain from values processed and assigned to altered neurological impulses at the spinal nerve level. Collectively these expressions form the bulk of clinical pictures and are termed to be that of autogenic pathology.

During WW11 a Russian physician demonstrated that patients even those with survival potential may be rendered to be without pulse or breath by the perpetuating nature of autogenic pathology. That after the patient is without pulse or breath autogenic pathology is still being expressed and survival potential might still exist.

If the ensuing anoxemia depresses the function of the brain in a sufficient and timely manner then the brain can no longer generate the previous expressions of autogenic pathology. This interruption of the expressions of autogenic pathology allowed pulse, breath, and survival potential to be restored.

Under the guise of defibrillating the heart the electrodes of the equipment previously used for electric shock therapy are now placed on the chest instead of the head. The current just as readily reached the brain as demonstrated by the resulting generalized convulsion. This depressed the brain more acutely than that of anoxemia alone to improve the rate of success. This success made electric shock therapy to be the mainstay of resuscitative efforts.

All who survive a resuscitative effort will have varying degrees of brain damage.

Some damage will be so severe that independent living is impossible. Those also with survival potential and yet who suffer terminal brain damage cannot be identified. If the carnage associated with the need for resuscitative efforts is to be circumvented then the expressions of autogenic pathology should be interrupted at the onset of therapy and at the safer spinal nerve level. The early interruption may do more to preserve survival potential then the other efforts of coronary and intensive care.

Otherwise some patients may be required to prove the presence of survival potential by surviving one or more resuscitative efforts.

Even when survival is not in question the interruption of autogenic pathology provides convalescences that are more comfortable, are of a shorter duration and are associated with a lesser degree of disability.

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During the development of the embryo as the labyrinths of spinal nerves branch and grow they capture and differentiate stem cells to grow specific segments of tissue and the organs they contain. These labyrinths maintain their segments by capturing an differentiating the necessary stem cells. These labyrinths define tissue segments that are both anatomical and neurological.

The neurological labyrinths of these segments function as a complete and independent neurological entity. Neurological impulses that are altered by distribution specific insults are first assigned relative processed values within its respective neurological labyrinth. These value generated at the spinal nerve level are then transferred to the central nervous system where they are processed into the expressions of autogenic pathology.

The relativity of values first processed and assigned to distribution specific altered neurological impulses is inversely related to the magnitude of cutaneous impulses that are generated through the skin’s contact with the external environment.

Therefore values become relativity insignificant when altered impulses are processed within an equation containing an excess of cutaneous impulses. Once altered neurological impulses receive a relatively insignificant processed value then they are no longer processed. Robbed of the necessary values streaming from the respective spinal nerve or nerves the central nervous system can no longer generate the previous expressions of autogenic pathology.

Going in a caudal direction and starting with C-3 visceral distributions become associated with the mid-gut. Visceral distributions are then dragged bilaterally in an intermingled manner as the mid-gut expands. Consequently starting with C-3 and going in a caudal direction visceral distributions are contributed by bilateral pairs of spinal nerves. These intermingled bilateral visceral distributions share the same anatomy but their physiology remains as independent as that of the location of their bilateral cutaneous distributions.

The unusual sensitivity of its cutaneous distribution identifies the labyrinth of a spinal nerve monitoring distribution specific anatomical insults. Consequently a spinal nerve harboring anatomical insults can be identified by the patient’s exaggerated response to distribution specific exploratory skin pricks. Placing exploratory skin pricks adjacent to the spine simplifies the correlation of cutaneous distributions with the identifying vertebrae. Even when documented visceral insults are correlated with the increased sensitivity of the cutaneous distribution of a specific or bilateral pairs of spinal nerves there are no patient variations. This not only establishes the presence of specific visceral distributions but also makes their mapping possible. Once this mapping is completed then visceral insults may be located to the anatomical sites of specific visceral distributions in real time.

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The autogenic pathology of multiple sites of abdominal visceral insults is an all or nothing expression. That is multiple visceral insults in the abdomen create perception and physiological changes that are of the same intensity whether the sites involve a single or multiple labyrinths. Therefore when the expression of autogenic pathology is interrupted at only one of multiple visceral sites the patient will experience no symptomatic relief. That is symptomatic relief will occur only when the autogenic pathology is interrupted at all of the multiple abdominal visceral insult sites. This is a fail safe mechanism that prevents multiple sites of abdominal visceral insults from being overlooked.

Undoubtedly some readers are of the opinion that peripheral distributions may be determined by dissection and if specific visceral distributions were present then they would have already been plotted. Nothing is further from the truth as terminal peripheral distributions cannot be determined by dissection. The lesions of multiple cases of Herpes zoster were used to plot the cutaneous distributions while the observable results of interrupting their continuity were used to plot somatic distributions.

Another way of defining autogenic pathology is to say it is that portion of clinical pictures whose expressions are deterred by anesthesia. Regardless of the route anesthesia is delivered all anesthetic routes are directed at preventing the expression of processed values that are assigned to altered impulses within the neurological labyrinths of individual spinal nerves.

General anesthesia depresses the function of the brain in a manner sufficient to prevent the processing of the values transferred from spinal nerves. Local and spinal anesthesia blocks the transfer of neurological values.

During surgery ongoing skin pricks of acupuncture generate a continuous stream of an excess of cutaneous impulses. The ongoing surgery also creates a string of altered impulses. When the stream of altered neurological impulses of surgery are processed within an equation containing a stream of an excess of cutaneous impulses then the relativity of processed values is destroyed. Without receiving the necessary processed values the brain can no longer generate the autogenic pathology that otherwise would have been expressed during surgery.

Acupuncture provides satisfactory anesthesia for a variety of surgical procedures including open chest surgery. These alert and active patient are able to verbally protest if the degree of anesthesia is inadequate. Unlike general and spinal anesthesia an excess of these benign skin pricks does not pose a risk to the patient. This makes the anesthesia of acupuncture to be safer than general and spinal anesthesia, and it also circumvents the brain damage associated with general anesthesia.

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Most of all of the above is summarized by the following hypothetical case.

The patient’s unmistakeable exaggerated response to exploratory skin pricks placed adjacent to bilateral T3-4 will confirm the suspicion of a myocardial infarction as accurately as any other single diagnostic test. Extending these skin pricks in a cephalic and caudal direction until the patient’s response is muted will interrupt the processing of the respective altered neurological impulses. This interruption of the expression of autogenic pathology will do more to preserve survival potential than the other efforts of even most of the coronary or intensive care units. The ability to conduct an accurate triage within a matter of one or two minutes and at the same time to effectively preserve survival potential is invaluable when dealing with an emergency situations such as that of a myocardial infarction.

The similar observations made during the treatment of Herpes zoster were not lost on shaman in Italy. Even as early as three thousand BC these shaman used the skin pricks of a dry run of the tattoo instrument to locate the site where the patient exhibited an exaggerated response. The site of this exaggerated response would identify that small area of skin where the skin pricks of tattoos would be accompanied by profound and often permanent symptomatic relief. Once a site of an exaggerated response was found then pigment was applied to the skin and then the resulting tattoo was extended in a cephalic and caudal direction until the patient’s response was muted. The Italian Iceman’s skin sports three short lines of tattoos that are to the left, adjacent, and parallel to the lumbar spine. From what is now known these tattoos provided the Iceman with relief of left lower extremity discomfort probably due to lumbar disc disease. More than likely these three lines of tattoos recorded three different treatment sessions. If repeated treatment became necessary the existing tattoos would eliminate the necessity of repeating the dry run of the tattoo instrument and also would permanently record previous treatment.

By making a bilateral dry run of the tattoo instrument and the extension of tattoos from the sites where the patient exhibited an exaggerated responses would have expanded these shamans’ ability. This would have given these shamans the ability to provide therapeutic and symptomatic benefits to patients suffering from visceral insults. These could have included myocardial infarctions, asthma, gastric and duodenal ulcers and others. In essence shamans’ treatment of an acute myocardial infarction might have done more to preserve survival potential then that of the other efforts of most coronary and intensive care units. Without the prior interruption of autogenic pathology too often a patient in coronary or intensive care may be required to prove the presence of survival potential by surviving one or more avoidable resuscitative efforts.

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It can be demonstrated that the herpetic lesions of the ophthalmic branch of the trigeminal nerve are the inflammatory response resulting from the alteration of the neurological impulses of C2 and are independent of the direct consequence of the herpetic virus. In this incidence the increased sensitivity of the cutaneous distribution of unilateral C-2 may be demonstrated by the patient’s exaggerated response to exploratory skin pricks. Extending these skin pricks in a cephalic and caudal direction will result in asymptomatic healing completed in a few days without scarring or post herpetic pain. This case demonstrates the therapeutic benefits that may be expected by just terminating the expression of autogenic pathology including the inflammatory process. The interruption of autogenic pathology may offer significant therapeutic benefits even when no other effective therapeutic measures are available.

Inflammatory responses are so uniquely specific that the origin of some viral infections may be diagnosed by the distribution and characteristics of their inflammatory response. In a similar fashion unique perceptions of clinical pictures may be used to determine the origin of insults. As an example the specific perceptions resulting from a burn will be different than that of a cut. A case in point is that of compromised glucose oxidation. Compromised glucose oxidation generates similar perceptions whether oxidation is compromised from the lack of circulation as the compression from increased hydrocephalic pressure, the lack of oxygen as in altitude sickness or from the lack of intracellular glucose available for oxidation.

Recurrent headaches are the most common symptoms of compromised glucose oxidation due to the lack of intracellular glucose available for oxidation. This lack of available glucose results from the physiological stress of a glucose overload. This overload is due to the excessive ingestion of simple carbohydrates. Local variations may make an aspect of one cerebral hemisphere more vulnerable and thus the term migraine.

Since unilateral hemispheres of the brain is grown and monitored by unilateral C-1 the generation of an excess of cutaneous impulses adjacent to unilateral C-1 will provide instantaneous symptomatic relief of migraine headaches. The origin of these headaches has been masked as symptoms may not occur up until twenty four hours or more after the last simple carbohydrate ingestion. Migraine headaches may be prevented by the dietary restriction of simple carbohydrates. These recurrent headaches fail to materialize when susceptible individuals develop sub- clinical or overt diabetes.

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Methodology

The relative neurophysiologic activity of a selected spinal nerve or nerves may be accessed, evaluated and modified by creating an excess of exploratory distribution specific cutaneous impulses. The patient’s unmistakeable exaggerated response to exploratory skin pricks is the hallmark of a spinal nerve monitoring distribution specific anatomical insults. The identification of the respective labyrinth is enhanced when exploratory skin pricks are placed adjacent to the spine and consequently to the identifying vertebrae. Once the site of an exaggerated response is found then skin pricks are extended in a cephalic and caudal direction until a more muted patient response is encountered. This extension assures that the processing equation contains an effective excess of cutaneous impulses. The profound usually permanent symptomatic relief that accompanies the extension of these skin pricks is considered to herald the termination of the processing of the respective altered neurological impulses. Robbed of values previously streaming from the respective spinal nerve or nerves the brain can no longer generate the previous expressions of autogenic pathology.

In spite of the above hyped hypotheses and theory the current level of knowledge precludes the ability to adequately justify neither the complexity of the neurophysiology expressed in clinical pictures nor the principles of the neurophysiology through which these expressions may be interrupted. Consequently these case studies are regimented by how rather than why. However some why had to be conjured to justify a more plausible explanation of how.

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case report

Taking a leap of faith by progressing from theory to utility, a patient with a localized burn was the first to be selected for treatment. A localized burn simplified the correlation of the insult with the cutaneous distribution of the respective spinal nerves. Also any therapeutic benefits, if any, could be observed directly. This patient happened to be a robust young service station attendant who suffered a seconddegree burn of his hand while removing the cap of a hot radiator.

After explaining that this was not a currently acceptable procedure but hopefully an effective treatment the patient consented. An exaggerated burst of pain in response to the generation of the respective cutaneous impulses was accompanied by the sudden onset of profound symptomatic relief. This rapid symptomatic relief resulted in the onset of a transit shock like state that was relieved by elevating the patient’s feet. After proper dressing of the burn he was able to safely return to his work place as no analgesics were required.

discussion

This case confirmed the fact that the generation of an excess of cutaneous impulses allowed access to, evaluation of, and modification of the physiology of the neurological labyrinths of the respective spinal nerves. Profound permanent pain relief, with minimal edema and bulla formation and rapid healing not only demonstrated symptomatic relief, but also demonstrated the therapeutic benefits obtained through terminating the associated inflammatory process.

case report

Due to economic necessity, a college student deferred medical care as long as possible. A sore throat that had prevented the swallowing of even saliva had left him dehydrated. The patient’s exaggerated response to exploratory skin pricks identified the neurological labyrinth harboring the initiating insult to lie within the visceral distributions of bilateral C-3. Profound symptomatic relief accompanied the generation of an excess of the respective cutaneous impulses. This made it possible for the patient to immediately and eagerly drink water without pain or difficulty in swallowing. Antibiotics were prescribed to cover possible bacterial infection. His recovery was rapid without further discomfort or difficulty in swallowing. Laboratory results received at a later time confirmed the suspicion of infectious mononucleosis.

discussion

This case demonstrates again that terminating the expressions of autogenic pathology even without altering the status of the infectious agent often produces an outpatient convalescence that may be superior to that available from current 8

hospitalization. Not only was the convalescence more comfortable, but it also was of a much shorter duration. The monetary savings were also substantial as the costs of hospitalization was circumvented. This case also hints of potential benefits that might be obtained from treating infections where effective therapies may not be available.

case report

Ten days after the over sewing of a ruptured duodenal ulcer, a housewife was still taking maximum doses of analgesics. In spite of the analgesics the lingering persistent severe discomfort made it difficult for the patient to eat or to sleep.

The generation of exploratory cutaneous impulses at bilateral L3-4 produced an exaggerated response. Extending these skin pricks was accompanied by profound symptomatic relief and improvement of her previously haggard appearance. The next day, her husband called to report that all she had done in the last 24 hours was to eat and to sleep.

discussion

On the completion of surgery permanently eliminating the expression of autogenic pathology would have provided a convalescence that was not only more comfortable but also one with a much shorter period of disability.

case report

A patient in coronary care was without appreciable relief even after receiving maximum doses of intravenous morphine for 24 hours. The generation of an excess of cutaneous impulses at bilateral T3-4 provided immediate symptomatic relief.

Recovery was uneventful without further discomfort or the need for any analgesics.

discussion

This case is another illustration of a situation in which maximum doses of analgesics, even after an appropriate period of time, failed to provide a satisfactory level of symptomatic relief. The termination of the expressions of autogenic pathology may have preempted this patient’s potential need for resuscitation. Since this interruption does not compromise the continued function of the nervous system, extension of the infarct would have prompted the immediate resurgence of symptoms. At the onset of therapy the patient’s unmistaken exaggerated response to the generation of exploratory cutaneous impulses at bilateral T3-4 would have confirmed the suspicion of a myocardial infarction as accurately as any other single test. Interrupting the expression of autogenic pathology probably did more to preserve survival potential

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than all of the other benefits offered by coronary care. His rapid recovery with little complications may have had something to do with the elimination of the accompanying inflammatory process.

case report

An elderly widow with persistent abdominal pain, and a normal hematological picture found relief from abdominal discomfort only after the completion of the generation of an excess of cutaneous impulses at both bilateral T6-7 and L3-4 levels.

Her pain continued to recur at approximately weekly intervals. She stated that recurrence of symptoms would progress from an asymptomatic state to unbearable discomfort in a matter of one hour. She also stated that she felt like she would rather die than to suffer the pain of the required treatment but she could not live with the persistent abdominal discomfort. After a negative colon evaluation and her third consultation with a surgeon and a gastroenterologist, an endoscope revealed both a duodenal and a gastric ulcer. Appropriate therapy provided an uneventful recovery.

discussion

This case presented at the earlier part of this study when efforts were concentrated more on symptomatic relief rather than the diagnostic potential. If at that time it had been known that bilateral T6-7 monitored the gastric area and that L3-4 monitored the duodenal area, perhaps endoscopy would have been performed during her first hospitalization. Even without a reputable hint of the origin of her symptoms the increased sensitivity of the cutaneous distributions consistently traced the originating insults to lie within the same two specific bilateral visceral distributions.

There were no appreciable changes in the patient’s symptoms until autogenic pathology had been interrupted at all four of the respective sites. This is a fail safe process that prevents multiple abdominal visceral insults from being overlooked. Also, the requirement for the generation of an excess of cutaneous impulses at all of the different sites and the instantaneous results eliminates any notion that this symptomatic relief is the result of hormonal actions as is commonly believed. The recurrence of her symptoms in the presence of ongoing ulcers in more or less on a weekly basis is in contrast to the permanent symptomatic relief expected when the respective insults are healing. Being able to correlate the specific anatomical location of documented visceral insults to the neurophysiology and distributions of specific pairs of bilateral spinal nerves forecasts the completion of the mapping of the mostly unknown though specific visceral distributions. Once mapping is completed, then visceral insults may be accurately located to specific anatomical sites in real time. This ability should make the accurate selection of definitive diagnostic studies more likely or even unnecessary.

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Though tentative and meager, the known visceral distributions are as follows: The unilateral cerebral hemisphere at C-1, the middle ear and the ophthalmic branch of the trigeminal nerve at unilateral C2. The pharynx including infectious mononucleosis at bilateral C-3. The bronchial tree and asthma at bilateral C7-T2.

Myocardial infarctions and the cardiac area at bilateral T3-4. The gastric area and gastric ulcers at bilateral T6-7. Duodenal ulcers and pyelonephritis are monitored by bilateral L3-4.

case report

An elderly male suffered an acute onset of severe discomfort and cramps in the right lower extremity. This episode was resolved by bed rest. Months later a more severe attack occurred which was not relieved by bed rest and required the use of crutches just to ambulate a few steps.

The creation of an excess of cutaneous impulses at unilateral L3-4 produced profound symptomatic relief that allowed this patient to ambulate symptom free for approximately one month before symptoms recurred. A second session of the generation of an excess of cutaneous impulses converted a recurrent acute episode into a bearable chronic state. An MRI performed after the first treatment revealed a 60-percent stenosis of the spinal cord by a protrusion at L3-4.

discussion

This case represented pressure on a nerve rather than nerve pathology. This may account for symptomatic relief that unexpectedly lasted much longer than that obtained by treating a neuritis or a case of causalgia. This case again demonstrates that exploiting the relativity of neurophysiology at the spinal nerve level may provide symptomatic relief of a quality superior to that of the usual current therapy.

case report

After several days of intensive care a boy with a burned hand failed to respond to resuscitative efforts.

discussion

This case occurred before the present information was current or accepted. If so then hypothetically at the onset of therapy an excess of cutaneous impulses would have been generated with unilateral skin pricks placed adjacent to the vertebrae identified by the cutaneous distribution of the burn. After proper dressing of the burn he could have been admitted for observation. If by the next morning he remained symptom free and his vital signs were stable he could have been discharged to be followed as an outpatient. This with the potential of a safe almost symptom free recovery. The benefits promised through terminating the autogenic pathology of a 11

burned hand might convert the decision to amputate to be more tentative. Amputation favors survival as it allows the more virulent autogenic pathology of a burn to be traded for the more benign picture of an amputation.

Summary

By exploiting the variables of the neurophysiology that forms the bulk of the pathology expressed as clinical pictures one may obtain with instantaneous efficiency convalescences that are not only safer but also are ones that are more comfortable, are of a shorter duration, and are associated with a lesser degree of disability. Even when survival is not in question interrupting the expression of autogenic pathology promises convalescences that are not only more comfortable, but are also of a shorter duration, with a lesser degree of disability. The ability to locate insults to the specific visceral distribution of specific bilateral pairs of spinal nerves and the invariable specificity of specific visceral distributions creates the potential for being able to locate visceral insults to be at specific anatomical sites in real time.

Reference: Collins H. Facilitating survival and recovery by removing autogenic pathology from the clinical picture, Med Hypo 98, Vol. 50, pp. 417-419.

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Is Low Dose Pooled IM Gamma Globulin the Treatment of Choice for all Malignancies?

Herbert W Collins MD FAAFP

There are two different interpretations of what is seen during the microscopic view of a slide prepared from a malignant mass. The currently accepted one dates to a time when it was thought cells were replaced through mitoses. During this time one saw a malignant mass that consisted of nuclei rich cells that are in various stages of mitoses. When one is cognizant of stem cell replacement then one sees a mass of nuclei rich stem cells that are in progressive stages of differentiation.

The answer to the question of the origin of malignancies awaits the decision of that little hairless genetically compromised mouse. If overtime the DNA of a successfully transferred malignant mass continues to be that of human cells then malignant masses are actually the result of the reproduction of a human cell that has undergone mutation.

However if overtime the DNA is converted to that of the mouse then malignant masses are due to an infection that has embraced the ability of nerves. That is to capture and to differentiate replacement stem cells into a specific cell type. .

A malignant mass converted from human cells to that of the mouse is now a satisfactory media for growing the respective infection. This media promises the means for producing a safe and effective vaccine.

Another source of an answer to this question comes from the fact that patient suffering from any type of malignancies will usually respond favorably to pooled gamma globulin. The effectiveness of gamma globulin indicates that the origin of all malignancies is that of an endemic infection.

The physiology and embryological development of all nerves are considered to be interchangeable. However in order to simplify this presentation only the labyrinths of spinal nerves are discussed. During the development of the embryo as the distal aspects of the labyrinths of spinal nerve’s branch and expand they capture and differentiate stem cells to grow and then to maintain by stem cell replacement specific segments of tissue and the organs they contain. This type of growth assures the absolute anatomical specificity of the distribution of the neurological labyrinths of each spinal nerve.

The fact that nerves are responsible for capturing and differentiating replacement stem cells is demonstrate by the selected atrophy of tissue segments follows the interruption of the continuity of its respective nerve.

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Cutaneous and somatic distributions differentiate cell types that are more or less generic for all spinal nerves. However visceral distributions differentiate cell types that are not only specific for the visceral distribution of an individual spinal nerve but are even unique for specific terminal endings of a specific visceral distribution.

If an infection is responsible for malignancies then fulfillment of the respective clinical picture necessitates that the infection incorporates the ability of the terminal aspect of a nerve’s labyrinth that it infects. That is it embraces the nerve’s ability to capture and to differentiate stem cells into specific cell types. To produce a malignant cell then this infection in theory not only embraces these abilities but also replicates and transmit these abilities to the new stem cells it captures and infects.

The friability of malignant masses and these embraced and transferred abilities gives even a single migratory malignant cell the ability to rapidly create a mass of cells destined to be differentiated into the same cell type as those of their origin.

Evidence indicates that the potential infectious agent for all malignancies could be a single entity. Like the shingles of the Herpes zoster virus the variable clinical course and the specific cell type of malignancies would be determined by which terminal aspect of which nerve is embraced. Consequently all the different sites of origin, cell type, and clinical pictures of any malignancy could be the result of a single endemic infection.

Beginning in the early nineteen fifties IM gamma globulin proved to be very effective in treating the general run of endemic bacterial and viral infections. As an example patients suffering from infectious mononucleosis or the flu would often be markedly improved or even cured overnight after receiving only one ml of IM pooled gamma globulin.

With all of the above in mind in the nineteen eighties a decision was made to use low dose pooled IM gamma globulin in an attempt to rehabilitate patients who had voluntarily opted out of seeking the recommended hospice care or who absolutely refused to accept the treatment offered by an oncologist. This was an important restriction as there was no intent to deprive patients of the benefits offered through the care of an oncologist. None of the patients selected had prior radiation or chemotherapy. Fractional low dose gamma globulin was chosen in order to magnify the significance of its observable therapeutic benefits.

case report

A patient in his early seventies suffered a myocardial infarction. Over the next few years his disability gradually increased until ambulation required the use of supplemental oxygen. During these years his deterioration was attributed to the normal progression of heart disease with some element of COPD. He became home bound and eventually his survival appeared to be in jeopardy. His daughter sensing that 14

he needed hospitalization persuaded her physician to admit him. After completion of the necessary diagnostic studies he was told that his liver was riddled with metastatic lesions from carcinoma of his colon. He continued to have uncontrollable diarrhea and died a few days after admission.

discussion

A myocardial infarction often is the first indication of a metastatic event. Since patients’ course of carcinoma sometimes parallels other chronic illnesses it is doubtful if the diagnosis of carcinomatosis would have been made but for the perchance of a change of attendants. This case also demonstrates the devastation that results when malignant cells act to compromise the function of a vital organ.

case report

A housewife witnessed the progress of her sister who died while receiving aggressive treatment for carcinoma of her breast. In view of her sister’s course she deferred seeking medical care for two years and was steadfast in her refusal to be seen or treated by an oncologist, a radiologist, or a surgeon. She agreed to be hospitalized with the condition that none of these physicians would be consulted.

She had hundreds of thousands if not millions of skin lesions, a mass in her other breast, and her bone marrow was involved. A skin biopsy was interpreted as being compatible with metastatic adenocarcinoma of the breast. She was discharged after she received one ml of IM gamma globulin. Two weeks after her first dosing her daughter called to report that her mother was getting well and that all the places in her skin had disappeared. One month after her first dosing she was readmitted.

Her previous anemia was corrected, the skin lesions now were barely detectable, the metastatic mass in her other breast was not evident on palpitation, and the primary lesion was reduced in size and had the feel of a breast that had been augmented by strips of rubber. A repeated skin biopsy was interpreted as being compatible with sclerosed metastatic adenocarcinoma of the breast. She continued to receive monthly IM injections of one ml of IM gamma globulin. Approximately thirteen months into her treatment she was readmitted with anemia thought to be due to GI bleeding. She refused any and all further diagnostic procedures and refused a possibly life saving transfusion.

discussion

This case is notable as the time delay in treatment allowed otherwise occult microscopic metastatic skin lesions to become detectable. This case also demonstrates that even when metastatic lesions do not involve the skin one should be mindful of

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the possibility of numerous occult sites of microscopic secondary lesions. One cannot explain the cause of the rapid demise of malignant cells as demonstrated by how quickly lesions become sclerosed once the effect of gamma globulin comes into play.

case report

After being evaluated by an oncologist an RN was told that her gastric carcinoma was inoperable and untreatable and she had voluntarily deferred the recommended hospice care. She received one ml of IM gamma globulin. She returned in approximately ten days after her first dosing with the right lobe of her liver so enlarged that it was palpable all the way down and into her pelvis. The left lobe had the feel and size of a half of a soccer ball. She denied discomfort and her liver enzymes were normal. She was rechecked approximately four weeks into her treatment with the liver now back to its normal size. Because of the dramatic changes from this first dosing and the lack of similar previous experience the patient, her sister, and I agreed to discontinue her treatment with gamma globulin and she died a few months later.

discussion

Discontinuing treatment was a big mistake as most of the tumor mass had been depleted and it is doubtful if continued treatment would have produced any unusual or untoward consequences. If treatment had been continued it is possible that she might have lived to develop an effective immune response and consequently a cure.

This case also demonstrates the fact that that a single low dose of pooled gamma globulin is not a cure.

case report

A ninety two year old grandmother had a four plus prolapsed uterus. On a return visit the previous prolapsed uterus was now corrected and she had a new mass in her right ovary. Evaluation by consultants resulted in the decision that because of her age treatment would not be in her best interest. She was given one ml of IM gamma globulin. When she returned one month later her prolapsed uterus was back and the size of the mass in her right ovary was reduced. Visiting nurses were given an order to continue the administration of one ml of IM gamma globulin on a once a month schedule. I had no further continuing contact with the patient. About two years into her treatment her daughter indicated that her mother wished that the gamma globulin be discontinued as her mother wished to die. This request was granted and I had no further contact with the patient or her family.

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case report

A WW11 navy veteran had an incomplete resection of a tumor in the arch of his aorta. A biopsy of the resected tumor proved to be that of a mesothelioma. After the patient had voluntarily deferred the recommended hospice care He was placed on monthly doses of one ml of IM pooled gamma globulin. Eighteen months into his treatment he developed a slight cough and chest X-rays showed that the remnants of the original tumor were now beginning to grow for the first time. The dose of gamma globulin was increased but without improvement. He survived and recovered from surgery for repair of a fracture of his hip. A few months later and during his terminal week he fractured his upper arm.

discussion

Increasing the dose of an ineffective batch of gamma globulin was a mistake.

Instead this ineffective batch of gamma globulin should have been replaced with another hopefully effective one . Fractures of long bones are frequently a consequence of terminal carcinoma.

Conclusions

Clinical observations demonstrate the universal therapeutic benefits of pooled gamma globulin and suggests that all malignancies may be the result of even a single endemic infection. Like the shingles of the herpetic virus the cell type, site of origin, and clinical pictures of malignancies seems to be dependent on which terminal aspect of which nerve is embraced by the responsible infectious agent. If that little hairless mouse succeeds in converting the human cells of a transferred malignant mass into that of the mouse then malignancies are due to an infection. If so then this same converted mass of non human cells becomes the growth media for the infection and consequently the source for the production of a safe and effective vaccine.

Reference: Collins H. facilitating survival and recovery by removing autogenic pathology from the clinical picture med hypo 98 vol 50 pp417-19.

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