Chemerin Signaling Pathway

Chemerin Signaling Pathway Adipose tissue is mainly distributed under the skin and around the organs, in which the proportion of subcutaneous fat is the largest, and the concentration of circulating adipokines is largely determined. Chemokines have been included in the adipokines family in recent years, and their receptors in the body are chemokine receptor 1, which is a proven class of antigen presenting cell chemokines. Studies have confirmed that chemerin and its receptors are mainly found in adipose tissue, antigen presenting cells and liver cells, which can regulate adipocyte differentiation, and serum chemerin concentration is associated with obesity and lipid metabolism disorders. Goralski et al found that mouse embryonic preadipocytes cultured in vitro can produce chemerin through autocrine or paracrine forms. On the one hand, they can activate downstream signaling pathways in cells, and regulate expression of glucose transporter-4, adiponectin, and leptin then affects glycolipid metabolism.

On the other hand, chemotaxis of dendritic cells or macrophages promotes local inflammatory response. Knockdown of chemerin or receptor genes in mice blocks mouse embryonic preadipocyte differentiation and alters mature adipocytes metabolic function, reducing body fat reserves. Population studies have shown that there is a positive correlation between serum chemerin levels and many inflammatory factors, while chronic low-grade inflammatory responses in obesity and metabolic syndrome patients are strong stimulant. CatalĂĄn et al. compared the metabolic indicators of obese patients with normal body types and found that serum chemerin concentration and C-reactive protein, von Willebrand factor, plasminogen activator inhibitor1, tumor necrosis factor- Îą , mononuclear cell chemoattractant protein-1 levels were highly correlated (P < 0.001), but the association no longer existed after adjusting for body mass index. Many scholars have suggested that serum chemerin concentration in the fasting state can be used as a biomarker for the degree of insulin resistance in healthy men, which is conducive to the early diagnosis and intervention of metabolic syndrome, while weight loss can significantly reduce serum chemerin levels. https://www.creative-diagnostics.com/chemerin-signaling-pathway.htm