Bioengineering & Biotechnology

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Contents Biomedical Engineering ....................................3 Bio MEMS, NEMS & Materials ........................14 Biomedical Imaging ........................................19 Biophysics ......................................................20 Biotechnology ................................................21 Page 5

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General Textbooks ..........................................26

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Biomedical Engineering Coming Soon!

Biofluid Mechanics The Human Circulation, Second Edition Krishnan B. Chandran University of Iowa, Iowa City, USA

Alit P. Yoganathan Georgia Institute of Technology, Atlanta, USA

Stanley E. Rittgers University of Akron, Ohio, USA

Heart failure and neurological deficits due to arterial diseases are the greatest causes of death in developed countries. Hence, fluid mechanical effects on the development and progression of the disease are of fundamental importance to researchers. In addition, the design and development of circulatory implants such as artificial heart valves, ventricular assist devices, and vascular grafts require knowledge of blood flow past these devices.

Examining the biodynamics of heart disease, this thoroughly updated edition of Biofluid Mechanics: The Human Circulation reviews the fluid mechanical analysis of blood flow in human arterial circulation. It focuses on the development and progression of arterial disease as well as the tools and technology at the cutting edge of treatment. Applying the theory of fluid mechanical principles in human circulation, the text evaluates the design and development of circulatory implants such as artificial heart valves, ventricular assist devices, and vascular grafts. This edition includes a new chapter on simulations.

Pedagogical Features: • Draws on the work of three outstanding researchers and academics in biofluid mechanics • Incorporates updates in every chapter • Includes significant new illustrations • Offers additional problems and examples • Presents an entirely new chapter on computational simulations Solutions manual available with qualifying course adoption

Catalog no. K12006, March 2012, 452 pp.

ISBN: 978-1-4398-4516-5, $104.95 Also available as eBook

Abridged Contents: FLUID AND SOLID MECHANICS AND CARDIOVASCULAR PHYSIOLOGY Fundamentals of Fluid Mechanics Intrinsic Fluid Properties Hydrostatics Macroscopic Balances of Mass and Momentum Microscopic Balances of Mass and Momentum Bernoulli Equation Dimensional Analysis Fluid Mechanics in a Straight Tube Boundary Layer Separation Introduction to Solid Mechanics Introduction to Mechanics of Materials Analysis of Thin-Walled Cylindrical Tubes Analysis of Thick-Walled Cylindrical Tubes Viscoelasticity Cardiovascular Physiology Heart Cardiac Valves Systemic Circulation Coronary Circulation Pulmonary Circulation and Gas Exchange in the Lungs Cerebral and Renal Circulations Microcirculation BIOMECHANICS OF THE HUMAN CIRCULATION Rheology of Blood and Vascular Mechanics Rheology of Blood Vascular Mechanics Static and Steady Flow Models Hydrostatics in the Circulation Applications of the Bernoulli Equation Unsteady Flow and Nonuniform Geometric Models Native Heart Valves CARDIOVASCULAR IMPLANTS, BIOMECHANICAL MEASUREMENTS, AND COMPUTATIONAL SIMULATIONS Prosthetic Heart Valve Dynamics Vascular Therapeutic Techniques Fluid Dynamic Measurement Techniques Computational Fluid Dynamic Analysis of the Human Circulation INDEX

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Biomedical Engineering Coming Soon!

Analysis and Application of Analog Electronic Circuits to Biomedical Instrumentation Second Edition Robert B. Northrop University of Connecticut, Storrs, USA

Biomedical engineering is an interdisciplinary science characterized by non-stationary signals acquired in the course of diagnosis and research and complex, non-linear, cross-coupled, time-variable systems from which these signals arise.

Covering such technologies as ECG, EEG, EMG, CM and DM Gain of Simple DA Stages at High and ERG along with heart and breath sounds, Frequencies blood pressure, and tomographic images, Input Resistance of Simple Transistor DAs Analysis and Application of Analog Electronic General Properties of Electronic, Single-Loop Circuits to Biomedical Instrumentation, Second Feedback Systems Edition provides a ready source of information on Classification of Electronic Feedback Systems how to understand and design signal conditioning Some Effects of Negative Voltage Feedback systems using analog integrated circuits. In this Feedback, Frequency Response, and Amplifier edition, Robert B. Northrop, a well-established Stability textbook author, has updated and revised the text Review of Amplifier Frequency Response substantially. The book now features three new What Is Meant by Feedback System Stability chapters that address power amplifiers and their Operational Amplifiers and Comparators applications to biomedical instruments, wireless The Ideal Op Amp patient monitoring, and RFID, GPS, and ultrasonic Practical Op Amps tags used in ecological research.

Gain-Bandwidth Relations for Voltage-Feedback OAs Pedagogical Features: Introduction to Analog Active Filters • Updates and revises all material in the text Active Filter Applications • Features three new chapters addressing Types of Analog Active Filters power amplifiers, wireless patient monitoring, Electronically Tunable AFs and RFID, GPS, and ultrasonic tags Instrumentation and Medical Isolation • Provides new end-of-chapter problems and Amplifiers examples Noise and the Design of Low-Noise Signal • Includes an extensive glossary Conditioning Systems for Biomedical Applications Solutions manual available with qualifying course adoption Descriptors of Random Noise in Biomedical Abridged Contents: Measurement Systems Propagation of Noise Through LTI Filters Sources and Properties of Biomedical Signals Noise Factor and Figure of Amplifiers Sources of Endogenous Bioelectric Signals Cascaded Noisy Amplifiers Nerve Action Potentials Digital Interfaces Muscle Action Potentials Modulation and Demodulation of Biomedical Properties and Models of Semiconductor Signals Devices Used in Analog Electronic Systems Power Amplifiers and Their Applications in pn Junction Diodes Biomedicine Midfrequency Models for BJT Behavior RFID Tags, GPS Tags, and Ultrasonic Tags The Differential Amplifier Used in Ecological Research DA Circuit Architecture Examples of Special Analog Circuits and Common-Mode Rejection Ratio Systems Used in Biomedical Instrumentation Appendix Catalog no. K12982, March 2012, 588 pp.

Glossary ISBN: 978-1-4398-6669-6, $119.95 Bibliography and Recommended Reading Also available as eBook

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Biomedical Engineering Biomedical Engineering Principles Second Edition Arthur B. Ritter, Vikki Hazelwood, Antonio Valdevit, and Alfred N. Ascione “ … not only an in-breadth overview on current BME fields, but also an indepth analysis of specific selected topics that are supported by appropriate mathematical models, equations, quantitative data charts and tables."

—Biomedical Engineering Online

" … an excellent textbook for a class."

—IEEE Engineering in Medicine and Biology Magazine

" … well-illustrated with figures, schemes, various plots, and mathematical equations."

—G. Ya. Wiederschain, Doctor of Biological Science, Moscow State University, Russia

Biomedical Engineering Principles, Second Edition provides a solid, accessible grounding to this rapidly advancing field. Acknowledging the vast range of backgrounds and prior education from which the biomedical field draws, the organization of this book lends itself to a tailored course specific to the experience and interests of the student.

Divided into four sections, the book begins with systems physiology, transport processes, cell physiology, and the cardiovascular system. Part I covers systems analysis, biological data, and modeling and simulation in experimental design, applying concepts of diffusion and facilitated and active transport. Part II presents biomedical signal processing, reviewing frequency, periodic functions, and Fourier series as well as signal acquisition and processing techniques.

Part III discusses practical applications of biomechanics, focusing on the mechanical and structural properties of bone, musculoskeletal, and connective tissue with respect to joint range, load bearing capacity, and electrical stimulation. The final part highlights capstone design, explaining design perspectives for living and nonliving systems, the role of the FDA, and the project timeline from inception to proof of concept.

Pedagogical Features: • Includes new chapters on capstone design in biomedical engineering and entrepreneurship

Contents: Introduction: Modeling of Physiological Processes Cell Physiology and Transport Principles and Biomedical Applications of Hemodynamics A Systems Approach to Physiology The Cardiovascular System Biomedical Signal Processing Signal Acquisition and Processing Techniques for Physiological Signal Processing Examples of Physiological Signal Processing Principles of Biomechanics Practical Applications of Biomechanics Biomaterials Principles of Biomedical Capstone Design.

Unmet Clinical Needs Entrepreneurship: Reasons why Most Good Designs Never Get to Market An Engineering Solution in Search of a Biomedical Problem to Solve Tissue Engineering Future Trends in BME

• Contains new coverage of systems biology and computational biology • Provides revised and updated chapters on the emerging field of tissue engineering • Offers extensive examples and in-chapter problems Catalog no. K10621, May 2011, 540 pp.

ISBN: 978-1-4398-1232-7, $99.95 Also available as eBook

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Biomedical Engineering

New Edition of a Bestseller!

Basic Transport Phenomena in Biomedical Engineering Third Edition Ronald L. Fournier University of Toledo, Ohio, USA

Encompassing a variety of engineering disciplines and life sciences, the very scope and breadth of biomedical engineering presents challenges to creating a concise, entry level text that effectively introduces basic concepts without getting overly specialized in subject matter or rarified in language. Basic Transport Phenomena in Biomedical Engineering, Third Edition meets and overcomes these challenges to provide beginning students with the foundational tools and the confidence they need to apply these techniques to problems of ever greater complexity.

Bringing together fundamental engineering and life science principles, this highly accessible text provides a focused coverage of key momentum and mass transport concepts in biomedical engineering. It offers a basic review of units and dimensions, material balances, and problemsolving tips, and then emphasizes those chemical and physical transport processes that have applications in the development of artificial and bioartificial organs, controlled drug delivery systems, and tissue engineering. The book also includes a discussion of thermodynamic concepts and covers topics such as body fluids, osmosis and membrane filtration, physical and flow properties of blood, solute and oxygen transport, and pharmacokinetic analysis. It concludes with the application of these principles to extracorporeal devices as well as tissue engineering and bioartificial organs.

Pedagogical Features: • Offers mathematical models using the “shell balance” and compartmental approaches • Includes numerous examples with a discussion of the numerical methods used to solve the problems • Supplies illustrations with homework problems at the end of each chapter • Contains an extensive bibliography of the research literature that supports the material in the text Solutions manual available with qualifying course adoption

Contents: Introduction A Review of Thermodynamic Concepts Physical Properties of the Body Fluids and the Cell Membrane The Physical and Flow Properties of Blood Solute Transport in Biological Systems Pharmacokinetic Analysis Extracorporeal Devices Tissue Engineering Bioartificial Ogans Index

Designed for the beginning student, this text provides a quantitative understanding of the underlying physical, chemical, and biological phenomena involved.

Catalog no. K11304, August 2011, 483 pp.

ISBN: 978-1-4398-2670-6, $89.95 Also available as eBook

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Biomedical Engineering

New!

Introduction to Biomedical Engineering Technology Second Edition Laurence Street Rosedale, British Colombia, Canada

Medical devices are often very complex, but while there are differences in design from one manufacturer to another, the principles of operation and, more importantly, the physiological and anatomical characteristics on which they operate are universal. Introduction to Biomedical Engineering Technology, Second Edition explains the uses and applications of medical technology and the principles of medical equipment management to familiarize students with their prospective work environment.

Written by an experienced biomedical engineering technologist, the book describes the technological devices, various hardware, tools, and test equipment used in today’s health-care arena.

Photographs of representative equipment; the technical, physiological, and anatomical basis for their function; and where they are commonly found in hospitals are detailed for a wide range of biomedical devices—from defibrillators to electrosurgery units.

This accessible text supplies an essential overview of clinical equipment and the devices that are used directly with patients in the course of their care for diagnostic or treatment purposes. The author’s practical approach and organization, outlining everyday functions and applications of the various medical devices, prepares students for situations they will encounter on the job.

Catalog no. K12781, October 2011, 391 pp.

ISBN: 978-1-4398-6058-8, $89.95 Also available as eBook

Pedagogical Features: • Incorporates real-life examples of the work that biomedical engineering technologists do • Contains examples, illustrations, and end-of-chapter questions to test students’ understanding • Provides appendices with useful information such as normal medical values, a list of regulatory bodies, internet resources, and information on training programs • Includes a 16-page grayscale insert with photographs of real-life equipment problems Solutions manual available with qualifying course adoption

Contents: Introduction Diagnostic Devices: Part One Diagnostic Devices: Part Two Diagnostic Devices: Part Three Diagnostic Imaging Treatment Devices: Part One Treatment Devices: Part Two Treatment Devices: Part Three Biomedical Engineering Technologist (BMET) Work Testers and Tools Batteries, Radiation, and Computers Technology Management Appendix A: Normal Values Appendix B: Regulations and Standards Appendix C: Biomedical Engineering Technology Programs in the United States and Canada Appendix D: Biomedical Associations Appendix E: Devices and Manufacturers Appendix F: Test Equipment Manufacturers Appendix G: Bibliography and Internet Resources Index

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Biomedical Engineering

Biomechanics of the Upper Limbs Mechanics, Modeling and Musculoskeletal Injuries, Second Edition Andris Freivalds Pennsylvania State University, University Park, USA

Over the past two decades, the growth in computer-related jobs has led to considerable increase in the number of work-related musculoskeletal disorders in the upper limbs. Now in its second edition, Biomechanics of the Upper Limbs: Mechanics, Modeling and Musculoskeletal Injuries offers vital information and tools to improve analysis of external forces and their effects on the human body. This can help future ergonomists better understand job stressors and the role they play in the development of disorders.

Using the author’s medical and engineering expertise to distill essential subject matter and useful technical data, this comprehensive text explores the biomechanics of the upper limbs and the motor control system and the structure and physiology of the human musculoskeletal and neuromuscular systems. It examines recent research findings and solutions to various ergonomic problems and presents models of various components of the neuromuscular systems, as well as larger systems in the upper limbs. It also explores the risk factors for disorders and tools used to identify their causes.

Pedagogical Features: • Includes figures, tables, problems, and examples • Contains end-of-chapter questions to test assimilation • Features downloadable PowerPoint® slides, sample exams, and other background material on a supporting website • Presents ample references to enhance further study Instructor’s manual available upon qualifying course adoption

Catalog no. 91190, February 2011, 564 pp.

ISBN: 978-1-4200-9119-9, $119.95 Also available as eBook

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Abridged Contents Introduction to Biomechanics What Is Biomechanics?

Basic Concepts Coordinate Systems Force Vector Algebra Static Equilibrium Anthropometry and Center of Mass Determination Friction Dynamics Structure of the Musculoskeletal System Gross Overview of Movements Skeletal System Mechanical Properties of Bone Soft Connective Tissue Joints Neuromuscular Physiology and Motor Control Introduction to Musculature Structure of Muscle Basic Cell Physiology Nervous System Excitation–Contraction Sequence Motor Units Basic Muscle Properties (Mechanics) Energy, Metabolism, and Heat Production Receptors Reflexes and Motor Control Modeling of Muscle Mechanics Laplace Transforms and Transfer Functions Viscoelastic Theory Hill’s Muscle Models Frequency Analysis Frequency Analysis of Passive Muscle Models of the Upper Limbs Musculoskeletal Disorders and Risk Factors Instrumentation Job and Worksite Analysis Hand Tools The Office Environment

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Biomedical Engineering

Biology for Engineers Arthur T. Johnson University of Maryland, College Park, USA

Biology is a critical application area for engineering analysis and design, and students in engineering programs must be well-versed in the fundamentals of biology as they relate to their field. Biology for Engineers is an introductory text that emphasizes concepts, technology, and the utilization of living things. Classroom-tested at the University of Maryland, this comprehensive text introduces concepts and terminology needed to understand more advanced biology literature.

The book explores scientific principles relevant to biology that all engineers must know. It discusses biological responses from the perspective of a broad range of fields such as psychology, human factors, genetics, plant and animal physiology, imaging, control systems, actuary, and medicine. It examines the scaling of biological responses and attributes and presents a classification of different types of applications related to biological systems. The text brings together all of the concepts one needs to understand the role of biology in modern technology.

Pedagogical Features: • Provides ample instruction on the basics of physics, chemistry, mathematics, and engineering • Minimizes unnecessary memorization of connections and classifications • Presents practical, detailed examples • Emphasizes the interactions between a biological unit and its physical, chemical, and biological environments • Presents tables of useful information nearly impossible to find elsewhere Solutions manual available with qualifying course adoption

Catalog no. 77635, September 2010, 775 pp.

ISBN: 978-1-4200-7763-6, $104.95 Also available as eBook

Abridged Contents: INTRODUCTION Science and Engineering Scientific Method Mathematical Modeling Biological Engineering Expectations for Biological Engineers About Predictions About This Book Questions PRINCIPLES FROM THE SCIENCES Principles of Physics Effort and Flow Variables Balances States of Matter Equivalence of Work and Energy Free Energy Disorder and Entropy Heat Transfer Movement of Materials Fluid Mechanics Solid Mechanics Electricity Temperature Effects Questions Principles of Chemistry Periodic Nature of Elements Chemical Bonding Chemical Equilibrium Acids and Bases Reaction Rates Carbon Chemistry Principles of Mathematics and Engineering Sciences Principles of Biology RESPONSES OF LIVING SYSTEMS Biological Responses in Context SCALING FACTORS UTILIZING LIVING SYSTEMS Biological Engineering Solutions APPENDICES REFERENCES

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Essential Titles from Bestselling Author Robert B. Northrop Signals and Systems Analysis in Biomedical Engineering Second Edition Robert B. Northrop University of Connecticut, Storrs, USA

The first edition of this text, based on the author’s thirty years of teaching and research on neurosensory systems, helped biomedical engineering students and professionals strengthen their skills in the common network of applied mathematics that tied together the diverse disciplines that comprise this field. Updated and revised to include new material as the field has grown, Signals and Systems Analysis in Biomedical Engineering, Second Edition continues to provide a ready source of information on those specialized mathematical techniques most useful in describing and analyzing biomedical signals.

This volume covers classical linear systems theory and its applications to biomedicine. It examines the important use of joint time-frequency analysis to characterize non-stationary physiological signals. It also explores the mathematics of tomographic imaging (the Radon transform, the Fourier slice theorem, and the filtered backprojection algorithm). The book also describes the analytical signal and the Hilbert transform and some of its biomedical applications.

Pedagogical Features: • Includes new chapters on nonlinear biochemical systems and biochemical oscillators • Contains a new chapter introducing complex systems and illustrating ways to best model them • Presents numerous examples that promote sound practical analysis • Supplies an extensive glossary as well as an ample listing of sources for further study • Provides extensive appendices to supplement the text, including “Simnon® Programs Used in Chapters 11 and 12,” “How to Use Root Locus to Determine the Stability of SISO Linear Feedback Systems,” “Signal Flow Graphs and Mason’s Rule,” and “Computational Tools for Biomedical Signal Processing and Systems Analysis” Solutions manual available with qualifying course adoption

Catalog no. K10633, March 2010, 654 pp.

ISBN: 978-1-4398-1251-8, $104.95

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Abridged Contents: Introduction to Biomedical Signals and Systems General Characteristics of Biomedical Signals General Properties of PSs Review of Linear Systems Theory Linearity, Causality, and Stationarity Analog Systems Systems Described by Sets of ODEs Linear System Characterization Discrete Signals and Systems Stability of Systems The Laplace Transform and Its Applications Introduction Properties of the Laplace Transform Some Examples of Finding Laplace Transforms The Inverse Laplace Transform Applications of the Laplace Transform Fourier Series Analysis of Periodic Signals Introduction Properties of the FS FS Examples The Continuous Fourier Transform Introduction Properties of the CFT ADC and the Sampling Theorem The Discrete Fourier Transform Introduction to Joint TimeFrequency Analysis of Biomedical Signals Introduction to the Analysis of Stationary Noise, and Signals Contaminated with Noise Basic Mathematical Tools Used in the Characterization of Physiological Systems Introduction to the Mathematics of Tomographic Imaging Introduction to the Analysis of Nonlinear Biochemical Systems and Biochemical Oscillators Introduction to Complex Systems in Biology and Medicine Glossary Appendices

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Essential Titles from Bestselling Author Robert B. Northrop

Introduction to Complexity and Complex Systems Robert B. Northrop University of Connecticut, Storrs, USA

The boundaries between simple and complicated, and complicated and complex system designations are fuzzy and debatable, even using quantitative measures of complexity. However, biomedical engineers, biologists, physiologists, economists, politicians, stock market speculators, and politicians all encounter complex systems. Their success depends on their ability to successfully interact with and manage a variety of complex systems. In order not to be blindsided by unexpected results, they need a systematic, comprehensive way of analyzing, modeling, and simulating complex systems to predict non-anticipated outcomes.

In its engaging first chapters, Introduction to Complexity and Complex Systems introduces Campbell's Law, the Law of Unintended Consequences, and the mathematics necessary for conversations in complex systems.

Subsequent chapters illustrate concepts via commonly studied biological mechanisms. The final chapters focus on higher-level complexity problems and introduce complexity in economic systems. This text is an ideal introduction to complex systems for advanced students studying biomedical engineering, biophysics, and physiology.

Pedagogical Features: • Describes the characteristics of certain complex living systems and provides dynamic models • Offers present-day examples to place the material in context • Includes homework problems for enhanced comprehension Catalog no. K11775, December 2010, 551 pp.

ISBN: 978-1-4398-3901-0, $83.95 Also available as eBook

Abridged Contents: Introduction to Complexity and Complex Systems Introduction to Complexity Why Study Complex Systems?

Human Responses to Complexity Complex Systems Engineering Chapter Summary Introduction to Large Linear Systems Linearity, Causality & Stationarity L TI System Tools Impulse Response, Frequency Response and Real Convolution Systems Described by Large Sets of Linear ODEs Stability of Linear Systems Signal Flow Graphs and Mason's Rule Introduction to Nonlinear Biochemical Systems and Biochemical Oscillators Modularity, Redundancy, Degeneracy, Pleiotropy and Robustness in Complex Biological Systems The Evolution of Biological Complexity; Invertebrate Immune Systems The Complex Adaptive and Innate Human Immune Systems Complexity in Quasispecies MicroRNAs Introduction to Physiological Complexity Examples of Models of Some Complex Physiological Systems The Quest for Quantitative Measures of Complexity "Irreducible and Specified Complexity" in Living Systems Introduction to Complexity in Economic Systems Dealing with Complexity Appendix Bibliography and References Glossary Index

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Biomedical Engineering

Bio MEMS, NEMS, & Materials

New!

Understanding Nanomedicine An Introductory Textbook Rob Burgess Medical Nanotechnologies Incorporated, Richardson, Texas, USA

The application of nanotechnology to medicine has burgeoned into a growing field, with funding from the National Institutes of Health and wide interest from all scientific sectors. Understanding Nanomedicine: An Introductory Textbook comprehensively covers a broad range of therapeutic and diagnostic applications of nanotechnology. Providing a dynamic learning experience, the book intersperses cutting-edge discoveries with historical perspectives. Preliminarily, the text discusses the basic principles of nanotechnology, focusing on nanomaterials and nanoparticles.

These are the sectors that hold the most promise for the future of medicine. The book then progresses to nanomedicine as it applies to current and future society.

Biomaterials A Nano Approach Seeram Ramakrishna, Murugan Ramalingam, T.S. Sampath Kumar, and Winston O. Soboyejo

Contents:

From a multi-disciplinary point of view, Biomaterials: A Nano Approach examines basic concepts, various processing methodologies, and techniques involved in the preparation and characterization of nanobiomaterials specific to biomedical applications. Spanning their historical development and reviewing recent advances in the field, it describes how basic concepts in nanotechnology are applied to the processing of novel nanobiomaterials, including nanostructured metals and alloys. It discusses materials used for biomedical applications, including tissue engineering and drug delivery, and describes the biological and environmental effects of nanomaterials. Presenting illustrative examples, case studies, exercises, and a variety of applications, this text offers a solid framework for understanding present and future trends of biomaterials in human health care systems.

Fundamentals of Nanotechnology

Contents:

Nanoparticles and Hyperthermic Cancer Therapeutics

Overview of Biomaterials

Nanofiber-Based Scaffolds and Tissue Engineering

Basics of Human Biology

Nanotechnology and Neuroscience

Failure and Tribology of Biomaterials

Nanotechnology and Surgery

Nanoscale Phenomena

Nanomatrices for Cell Culture

Metallic Biomaterials

Nanoparticle-Based Drug Delivery

Ceramic Biomaterials

Nanodiagnostics

Polymeric Biomaterials

Government Influence on Nanotechnology

Composite Biomaterials

Future Concepts in Nanomedicine

Nanobiomaterials for Tissue Engineering

Catalog no. N10477, February 2012, 350 pp.

ISBN: 978-981-4316-38-5, $149.95 Also available as eBook

Glossary

Degradation and Corrosion of Biomaterials

Exercises References Catalog no. 47817, June 2010, 372 pp.

ISBN: 978-1-4200-4781-3, $99.95

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Biomedical Engineering New!

An Introduction to Biomaterials Second Edition Edited by

Jeffrey O. Hollinger Carnegie Mellon University, Pittsburgh, Pennsylvania, USA

A practical road map to the key families of biomaterials and their potential applications in clinical therapeutics, Introduction to Biomaterials, Second Edition follows the entire path of development from theory to lab to practical application. It highlights new biocompatibility issues, metrics, and statistics as well as new legislation for intellectual property.

Divided into four sections (Biology, Biomechanics, Biomaterials Interactions; Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property; Biomaterials Compositions; and Biomaterials Applications), this dramatically revised edition includes both new and revised chapters on cells, tissues, and signaling molecules in wound healing cascades, as well as two revised chapters on standardized materials testing with in vitro and in vivo paradigms consistent with regulatory guidelines. Emphasizing biocompatibility at the biomaterial-host interface, it investigates cell-cell interactions, cell-signaling and the inflammatory and complement cascades, specific interactions of protein-adsorbed materials, and other inherent biological constraints, including solid-liquid interfaces, diffusion, and protein types. Unique in its inclusion of the practicalities of biomaterials as an industry, the book also covers the basic principles of statistics, new US FDA information on the biomaterials-biology issues relevant to patent applications, and considerations of intellectual property and patent disclosure.

This comprehensive, yet manageable didactic work is an invaluable desk reference and instructional text for undergraduates. This volume is an ideal text alongside A Laboratory Course in Biomaterials (p. 14).

Pedagogical Features: • Includes nine completely new chapters and 24 chapters extensively updated and revised with new accomplishments and contemporary data • Explains in vitro and in vivo testing paradigms and provides numerous examples in the chapters on experimental design, laboratory assays, and animal models • Contains end-of-chapter questions and answers • Includes extensive references for further study

Abridged Contents: Consensus Definitions, Fundamental Concepts, and a Standardized Approach to Applied Biomaterials Sciences Biology, Biomechanics, Biomaterial Interactions: Wound Healing Biology Cutaneous Wound Pathobiology: Raison d’etre for Tissue Engineering Osseous Wound Healing Biology, Biomechanics, Biomaterial Interactions: Cellular Mechanics Cell and Tissue Mechanobiology Biology, Biomechanics, Biomaterial Interactions: Materials–Host Interactions Cell–Material Interactions: Fundamental Design Issues for Tissue Engineering and Clinical Considerations Host Response to Biomaterials Protein Adsorption at the Biomaterial–Tissue Interface Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Standardized Materials Testing In Vitro Testing of Biomaterials. Assessment of Biomaterials: Standardized In Vivo Testing Biomaterials Testing, Statistics, Regulatory Considerations, Intellectual Property: Statistics Basic Principles of Statistics: Considerations for Biomaterials Engineers Therapy Development, Animal Testing, and Regulatory Issues Biomaterials Compositions Biomaterials Applications Index

Catalog no. K10637, November 2011, 644 pp.

ISBN: 978-1-4398-1256-3, $119.95 Also available as eBook

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Bio MEMS, NEMS & Materials

A Laboratory Course in Biomaterials Wujing Xian University of Illinois at Urbana-Champaign, USA

The field of biomedical engineering has vastly expanded in the past two decades, as reflected in the increased number of bioengineering and biomaterials programs at universities. The growth of this area has outpaced the development of laboratory courses that allow students hands-on experience, since the barriers involved in creating multidisciplinary biomaterials laboratory courses are high. A teaching tool for instructors in biomaterials and bioengineering, A Laboratory Course in Biomaterials is a comprehensive laboratory textbook and an ideal supplement to An Introduction to Biomaterials, Second Edition (p. 13).

This volume trains students in laboratory skills, data analysis, problem solving, and scientific writing and integrates a variety of principles that include materials science, chemistry, biochemistry, molecular and cell biology, and engineering.

Providing detailed descriptions, explanations, and illustrations of experiments, the text also includes a series of questions and answers at the end of each chapter to clarify concepts. Many of the experiments presented are adapted from research papers to reflect the recent progress in biomaterials and bioengineering.

Pedagogical Features: • Presents detailed, step-by-step descriptions of lab procedures and explanations for the underlying principles • Contains user-friendly graphic illustrations for the experiments • Provides a series of questions and answers at the end of each chapter to clarify concepts and induce critical thinking • Includes text boxes with in-depth information, case studies, and lab tips • Offers information on equipment, reagents, and supplies for instructors Catalog no. 75829, June 2009, 216 pp., Soft Cover ISBN: 978-1-4200-7582-3, $64.95

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Abridged Contents: Basic Laboratory Skills Commonly Used Lab Equipment and Supplies Waste Disposal Liquid Transfer Weighing Making Solutions Error Analysis Module I. Drug Delivery: Controlled Release of Encapsulated Protein from PLGA Encapsulation of BSA in PLGA Microspheres Evaluation of the Encapsulation Efficiency and the Drug Load Controlled Release of BSA from PLGA Microspheres Evaluation of Controlled Release Profile Questions Appendix: Recipes and Sources for Equipment, Reagents, and Supplies Module II. Natural Biomaterials: Collagen and Chitosan Extracting Acid-Soluble Type I Collagen from Bovine Calf Skin Purification of Extracted Collagen Analysis of Collagen Extraction and Purification

by Electrophoresis Fabricating Collagen/Chitosan Sponges Questions Appendix: Recipes and Sources for Equipment, Reagents and Supplies Basic Laboratory Skills II. Cell Culture and Microscopy Cell Culture Exercises Module III. Biocompatibility Testing: Cytotoxicity and Adhesion Module IV. Tissue Engineering: Organotypic Cultures of Skin Equivalents Module V. Bioceramics: Porous Hydroxyapatite Composite Appendix: Answers

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Bio MEMS, NEMS & Materials

From MEMS to Bio-MEMS and Bio-NEMS Manufacturing Techniques and Applications Marc J. Madou University of California, Irvine, USA

From MEMS to Bio-MEMS and Bio-NEMS: Manufacturing Techniques and Applications details manufacturing techniques applicable to bionanotechnology. After reviewing MEMS techniques, materials, and modeling, the book covers nanofabrication, genetically engineered proteins, artificial cells, nanochemistry, and self-assembly. It discusses nonlithography manufacturing techniques with lithography-based methods. It reviews packaging, assembly, and self-assembly from ICs to DNA and biological cells. It also explores selected new MEMS and NEMS processes and materials, metrology techniques, and modeling.

Additional sections in the book explore scaling laws, actuators, power generation, and the implementation of brains in miniaturizes devices. The author also reviews different strategies for making micromachines smarter and discusses the transition out of the laboratory and into the marketplace The third volume in Fundamentals of Microfabrication and Nanotechnology, Third Edition, Three-Volume Set, the book discusses topdown and bottom-up manufacturing methods and explains how to use nature as a guide. It provides a better understanding of how to match different manufacturing options with a given application that students can use to identify additional MEMS and NEMS applications.

Other volumes in the set include: Solid-State Physics, Fluidics, and Analytical Techniques in Microand Nanotechnology Manufacturing Techniques for Microfabrication and Nanotechnology.

Pedagogical Features: • Focuses on applications of NEMS and MEMS • Includes end-of-chapter problems as well as worked-out problems within the text • Contains color illustrations throughout, extensive references for further reading, and a comprehensive glossary of terms Solutions manual, PowerPoint® lecture slides, and electronic figures available with qualifying course adoption

Contents: From Traditional Manufacturing to Nanotechnology Nonlithography-Based (Traditional) and Lithography-Based (Nontraditional) Manufacturing Compared Nature as an Engineering Guide: Biomimetics Nanotechnology: Top-Down and Bottom-Up Manufacturing Approaches Compared Packaging, Assembly, and Self-Assembly Selected Materials and Processes for MEMS and NEMS Metrology and MEMS/NEMS Modeling Scaling Laws, Actuators, and Power and Brains in Miniature Devices Scaling Laws Actuators Power and Brains in Miniature Devices Miniaturization Application MEMS and NEMS Applications

Catalog no. 5516X, June 2011, 650 pp.

ISBN: 978-1-4200-5516-0, $99.95 Also available as eBook

For more information and complete contents, visit www.crctextbooks.com

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Bio MEMS, NEMS & Materials

BioMEMS Science and Engineering Perspectives Simona Badilescu and Muthukumaran Packirisamy Concordia University, Montreal, Canada

As technological advancements widen the scope of applications for biomicroelectromechanical systems (BioMEMS or biomicrosystems), the field continues to impact many aspects of life science operations and functionalities. Because BioMEMS research and development require the input of experts who use different technical languages and come from varying disciplines and backgrounds, scientists and students can avoid potential difficulties in communication and understanding only if they possess a skill set and understanding that enables them to work at the interface of engineering and biosciences.

Keeping this duality in mind throughout, BioMEMS: Science and Engineering Perspectives supports and expedites the multidisciplinary learning involved in the development of biomicrosystems. Divided into nine chapters, it starts with a balanced introduction of biological, engineering, application, and commercialization aspects of the field. With a focus on molecules of biological interest, the book explores the building blocks of cells and viruses, as well as molecules that form the self-assembled monolayers (SAMs), linkers, and hydrogels used for making different surfaces biocompatible through functionalization.

Because BioMEMS is an application-driven field, the book also highlights the concepts of lab-on-achip (LOC) and micro total analysis system ( TAS), along with their pertinence to emerging point-ofcare (POC) and point-of-need (PON) applications.

Pedagogical Features: • Provides a concise overview of BioMEMS principles • Incorporates modern applications • Covers fabrication techniques • Includes examples and problems in each chapter • Offers references, review questions, and case studies to aid comprehension Solutions manual available with qualifying course adoption

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Abridged Contents: Introduction Introduction to BioMEMS Application Areas Intersection of Science and Engineering Evolution of Systems Based on Size Commercialization, Potential, and Market Substrate Materials Used in BioMEMS Devices Metals Glasses and Ceramics Silicon and Silicon-Based Surfaces Polymers Biopolymers Organic Molecules (Functional Groups) Involved in the Formation of Self-Assembled Monolayers Biomolecules and Complex Biological Entities: Structure and Properties Amino Acids Polypeptides and Proteins Lipids Nucleotides and Nucleic Acids Carbohydrates Enzymes Cells Bacteria and Viruses Engineering of Bioactive Surfaces Plasma Treatment and Plasma-Mediated Surface Modification Surface Modifications Mediated by SelfAssembled Monolayers (SAMs) Methods of Study and Characterization of Surface-Modified Substrates Biosensing Fundamentals Fabrication of BioMEMS Devices Introduction to Microfluidics BioMEMS Catalog no. K10877, April 2011, 368 pp.

ISBN: 978-1-4398-1699-8, $99.95 Also available as eBook

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Bio MEMS, NEMS & Materials

Biomedical Microsystems Ellis Meng University of Southern California, Los Angeles, USA

Poised to dramatically impact human health, biomedical microsystems (bioMEMS) technologies incorporate various aspects from materials science, biology, chemistry, physics, medicine, and engineering. Reflecting the highly interdisciplinary nature of this area, Biomedical Microsystems covers the fundamentals of miniaturization, biomaterials, microfabrication, and nanotechnology, along with relevant applications.

Written by an active researcher who was recently named one of Technology Review’s Young Innovators Under 35, the book begins with an introduction to the benefits of miniaturization. It then introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author also covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering.

For students with a limited background in MEMS and bioMEMS, this book provides a practical introduction to the technology used to make these devices, the principles that govern their operation, and examples of their application. It offers a starting point for understanding advanced topics and encourages students to begin to formulate their own ideas about the design of novel bioMEMS.

Pedagogical Features: • Emphasizes practical knowledge useful for application to real-world problems • Describes research and commercialized bioMEMS devices as well as emerging applications • Includes detailed examples, laboratory exercises, and a variety of homework problems • Contains numerous illustrations of concepts, processes, and devices • Offers downloadable original images for qualifying instructors at www.crcpress.com Solutions manual available with qualifying course adoption

Abridged Contents: Introduction Evolution of MEMS Applications of MEMS BioMEMS Applications MEMS Resources Text Goals and Organization Miniaturization and Scaling BioMEMS Materials Traditional MEMS and Microelectronic Materials Polymeric Materials for MEMS Biomaterials Microfabrication Methods and Processes for BioMEMS Introduction Microlithography Doping Micromachining Wafer Bonding, Assembly, and Packaging Surface Treatment Conversion Factors for Energy and Intensity Units Microfluidics Introduction and Fluid Properties Concepts in Microfluidics Fluid-Transport Phenomena and Pumping Flow Control Lab-on-a-Chip or Micro Total Analysis Systems Microanalytical Systems in Chemistry and Biology Sample Pretreatment Sensing and Detection Methods Applications to Cells, Nucleic Acids, and Proteins Clinical Monitoring MEMS Implants and Bioelectric Interfaces Index Catalog no. 51229, September 2010, 408 pp.

ISBN: 978-1-4200-5122-3, $94.95 Also available as eBook

For more information and complete contents, visit www.crctextbooks.com

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Biomedical Imaging Coming Soon!

Biomedical Signal and Image Processing

Applied Medical Image Processing

Second Edition

A Basic Course

Kayvan Najarian

Wolfgang Birkfellner

Virginia Commonwealth University, Richmond, USA

Medical University of Vienna, Austria

Written for senior-level and first year graduate students in biomedical signal and image processing, Biomedical Signal and Image Processing, Second Edition describes fundamental signal and image processing techniques that are used to process biomedical information. The book also discusses application of these techniques in the processing of some of the main biomedical signals and images, such as EEG, ECG, MRI, and CT. New features of this edition include the technical updating of each chapter along with the addition of many more examples, the majority of which are MATLAB® based.

Pedagogical Features: • Includes updated chapters and all-new examples • Presents expanded end-of-chapter questions • Offers enhanced illustration of concepts presented in the first edition Solutions manual available with qualifying course adoption

Contents:

—William Hendee in Medical Physics

“[A]n outstanding work … [t]he text is easy to follow … . In each well-organized chapter, important concepts and definitions are described concisely and well. … The book is enjoyable to read … students will find the entire volume to be filled with important information.”

—Edward J. Ciaccio, Columbia University, BioMedical Engineering OnLine

“I have found this book very useful … . It is comprehensive and well written.”

—Terry Peters, The University of Western Ontario

“This is a lucid, well-written, and hands-on textbook that explains in simple terms and with examples the basic issues of medical image processing.

It contains many examples and useful programs.”

—Leo Joskowicz, The Hebrew University of Jerusalem

Introduction to Digital Signal and Image Processing. Signals and Biomedical Signal Processing. Fourier Transform. Image Filtering, Enhancement, and Restoration. Edge Detection and Segmentation of Images. Wavelet Transform. Other Signal and Image Processing Methods. Clustering and Classification.

Processing of Biomedical Signals. Electrical Activities of Cell. Electrocardiogram.

Electroencephalogram. Electromyogram.

Other Biomedical Signals. Processing of Biomedical Images. Principles of Computed Tomography. X-Ray Imaging and Computed Tomography. Magnetic Resonance Imaging.

Ultrasound Imaging. Positron Emission Tomography. Other Biomedical Imaging Techniques. Related Titles. Index.

Catalog no. K13235, May 2012, 448 pp.

ISBN: 978-1-4398-7033-4, $99.95 Also available as eBook

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“The CD adds substantial value to the text and serves as an excellent guide to practice the information covered in the text. … Several books on image processing have been published recently, and this book takes a backseat to none of them. … Students who take a course where this book is used as the course text will be fortunate indeed.”

Pedagogical Features: • Requires little more than basic algebra and basic programming skills • Provides a self-contained, complete basic introduction to the field, emphasizing special requirements for processing medical imaging data • Covers three-dimensional volume data sets commonly encountered in tomographic imaging • Addresses the most frequently used visualization techniques in medical imaging, including image segmentation, 3D image fusion, and tomographic reconstruction • Includes many practical examples for MATLAB and Octave with a CD-ROM featuring image material and program files Catalog no. K11176, September 2010, 403 pp.

ISBN: 978-1-4398-2444-3, $72.95 Also available as eBook

Request your Complimentary eBook or Print Exam Copy at www.crctextbooks.com

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Biophysics Quantitative Understanding of Biosystems

New!

Dynamics of Biological Systems

An Introduction to Biophysics Thomas M. Nordlund University of Alabama at Birmingham, USA

Michael Small Hong Kong Polytechnic University, Kowloon

“A beautiful review of essential physics for understanding biological systems.”

—Ernest Barreto, George Mason University

“This book is so far the best on the market in terms of an undergraduate biophysics textbook.”

—Liviu Movileanu, Syracuse University

“Particularly, it is nice how the book builds up toward the main equations to make them intuitive from basic principles.”

—Diego Krapf, School of Biomedical Engineering, Colorado State University

“ [A] nice exposition on the differences between how a biologist approaches a problem and how a physicist does.”

—Charles Wolgemuth, University of Connecticut Health Center

“A superb pedagogical textbook about the behavior and properties of the microscopic structures that form the essential building blocks of living systems.”

—Midwest Book Review

Pedagogical Features: • Provides a hands-on understanding of the movement of microorganisms, enabling students to analyze positions, velocities, and forces of real microorganisms • Reviews the necessary mathematics, including geometry, calculus, and differential equations • Discusses quantum mechanics in biosystems, covering photosynthesis and micro and chemical reactions • Describes the transition from discreet random walks to continuum diffusive motion • Contains standard exercises, advanced problems, and miniprojects • Includes a CD-ROM with "active" versions of Excel graphs and diagrams from the text, along with links to mathematical and biological/biochemical source data Solutions manual available with qualifying course adoption

Catalog no. 89772, March 2011, 583 pp.

ISBN: 978-1-4200-8972-1, $89.95 Also available as eBook

From the spontaneous rapid firing of cortical neurons to the spatial diffusion of disease epidemics, biological systems exhibit rich dynamic behavior over a vast range of time and space scales.

Unifying many of these diverse phenomena, Dynamics of Biological Systems provides the computational and mathematical platform from which to understand the underlying processes of the phenomena.

Through an extensive tour of various biological systems, the text introduces computational methods for simulating spatial diffusion processes in excitable media, such as the human heart, as well as mathematical tools for dealing with systems of nonlinear ordinary and partial differential equations, such as neuronal activation and disease diffusion. The mathematical models and computer simulations offer insight into the dynamics of temporal and spatial biological systems, including cardiac pacemakers, artificial electrical defibrillation, pandemics, pattern formation, flocking behavior, the interaction of autonomous agents, and hierarchical and structured network topologies. Tools from complex systems and complex networks are also presented for dealing with real phenomenological systems.

Pedagogical Features: • Uses complex systems, complex networks, and dynamics to derive models and computer simulations of various biological systems • Presents a wide range of models, from ECG signal processing to pandemic modelling to population dynamics • Requires no advanced knowledge of mathematics • Includes exercises as well as computational and research projects at the end of each chapter • Offers MATLAB implementations of many key algorithms and various case studies on the author’s website Solutions manual available with qualifying course adoption

Catalog no. K12463, August 2011, 284 pp.

ISBN: 978-1-4398-5336-8, $79.95 Also available as eBook

For more information and complete contents, visit www.crctextbooks.com

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Biophysics New!

New!

Physics for Diagnostic Radiology Third Edition

Physiology, Biophysics and Biomedical Engineering

P. P. Dendy

Edited by

Addenbrookes NHS Trust, Cambridge, UK

Andrew W. Wood

B. Heaton Aberdeen Radiation Protection Services, UK

“ … written in a clear and concise style, supported by excellent illustrations. The textbook describes recent state-of-the-art advances in medical imaging in a way radiologists, radiographers and medical physicists will find easy to understand. It is internationally recognised as one of the key textbooks in its field.”

—Dr. Keith Faulkner, North East Strategic Health Authority, UK

Fully revised and updated, Physics for Diagnostic Radiology, Third Edition helps students understand how various imaging techniques work. This edition includes new chapters on PET and PACS as well as new material on digital receptors, radiation doses and risks to patients, and special radiographic techniques, including subtraction techniques and interventional radiology. It also emphasizes the differences between analogue and digital images and covers multi-slice CT and three-dimensional resolution, dual energy applications, and cone beam CT.

Pedagogical Features: • Explains the underlying physical principles of imaging techniques • Encourages lateral thinking wherever possible, pointing out the similarities of concepts across different modalities • Follows the guidelines issued by the European Federation of Organisations in Medical Physics for training in diagnostic radiology • Contains end-of-chapter exercises as well as several multiple choice questions at the back of the book to test comprehension • Includes extensive cross-referencing, text references, and recommendations for further reading Catalog no. 83155, August 2011, 720 pp.

ISBN: 978-1-4200-8315-6, $79.95 Also available as eBook

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Swinburne University of Technology, Victoria, Australia

Physiology, Biophysics and Biomedical Engineering provides a multidisciplinary understanding of biological phenomena and the instrumentation for monitoring these phenomena. It covers the physical phenomena of electricity, pressure, and flow along with the adaptation of the physics of the phenomena to the special conditions and constraints of biological systems. While the text focuses on human biological systems, some of the principles also apply to plants, bacteria, and other animals.

The first section of the book presents a general introduction to physiological systems and describes specialized methods used to record electrical events from biological tissue. The next part examines molecules involved in cell transport and signaling as well as the proteins relevant in cells’ ability to contract and generate tension. The text goes on to cover the properties of the heart, blood, and circulation and the monitoring of cardiac and circulatory function. It then discusses the importance of the interrelationship of pressures and flows in organ systems, such as the lungs and kidneys, and details the organization and function of the nervous system. After focusing on the systems used to monitor signals, the book explores modeling, biomechanics, and emerging technologies, including the progressive miniaturization of sensors and actuators in biomedical engineering.

Pedagogical Features: • Offers a multidisciplinary approach to human biological systems • Highlights the application of physics and engineering methods to medicine and biology • Gives students a solid basis for understanding the physiological processes in the human body • Draws on the classroom material of experienced lecturers • Incorporates a range of numerical problems with worked solutions Solutions manual available with qualifying course adoption

Catalog no. C6513, February 2012, 782 pp.

ISBN: 978-1-4200-6513-8, $99.95 Also available as eBook

Request your Complimentary eBook or Print Exam Copy at www.crctextbooks.com

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Biotechnology New!

Biotechnology Fundamentals Firdos Alam Khan Manipal University, Dubai, United Arab Emirates

The focus of Biotechnology Fundamentals is to educate readers on both classical and modern aspects of biotechnology and to expose them to a range of topics, from basic information to complex technicalities. Other books cover subjects individually, but this text offers a rare topical combination of coverage, using numerous helpful illustrations to explore the information that students and researchers need to intelligently shape their careers.

Keeping pace with the rapid advancement of the field, topics covered include how biotechnology products are produced, the differences between scientific research conducted in universities and that conducted in industry, which areas of biotechnology offer the best and most challenging career opportunities, and key laboratory techniques and protocols employed in the field.

The contents of this book are derived from discussions between teachers and undergraduate students and designed to address the concepts and methods thought useful by both sides. Starting with the fundamentals of biotechnology, coverage includes definitions, historical perspectives, timelines, and major discoveries, in addition to products, research and development, career prospects, ethical issues, and future trends.

Pedagogical Features: • Includes information on current research trends • Covers novel medical genetics topics such as intra-uterine insemination • Discusses the process of biotech product development, with suitable examples • Examines ethical issues within biotechnology research and product development (e.g. embryonic stem cells, cloning, gene therapy, and GM crops) • Includes learning objectives for each chapter, in addition to problems, lab assignments, references, and ancillary online resources • Suggests field trips that can be used to apply and better understand concepts and other material in the book Solutions manual available with qualifying course adoption

Abridged Contents: Introduction to Biotechnology What Is Biotechnology?

Animal Biotechnology Agricultural Biotechnology Medical Biotechnology Industrial Biotechnology Environmental Biotechnology Other Emerging Fields of Biotechnology History of Biotechnology Human Genome Project Major Scientific Discoveries in Biotechnology Biotechnology as the Science of Integration Bio-Revolution Ethical and Regulatory Issues in Biotechnologyy Genes and Genomics Introduction Cell as the Building Block of Life Genes and Genetics DNA Replication DNA Interactions with Proteins DNA-Modifying Enzymes DNA Methylation DNA Mutation Proteins and Proteomics Recombinant DNA Technology Microbial Biotechnology Agricultural Biotechnology Animal Biotechnology Environmental Biotechnology Medical Biotechnology Nanobiotechnology Product Development in Biotechnology Industrial Biotechnology Ethics in Biotechnology Careers in Biotechnology Laboratory Tutorials Glossary Catalog no. K11059, September 2011, 608 pp.

ISBN: 978-1-4398-2009-4, $89.95 Also available as eBook

For more information and complete contents, visit www.crctextbooks.com

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Biotechnology Biotechnology Operations Principles and Practices Michael J. Roy University of Wisconsin-Madison, USA

Based on the author's extensive teaching experience, Biotechnology Operations: Principles and Practices introduces key biotechnology developments and covers critical elements of biotechnology operations. Comprehensive and practical, but with a focus on fundamentals, it emphasizes the themes of planning and integrating the seven key operational endeavors: scientific and management skills of biomanufacturing, clinical trials, nonclinical studies, project management, quality assurance, quality control, and regulatory affairs. The author discusses these subjects in relation to development planning, process and pathways, management of integrated projects, and the business and economic aspects of development.

Describing the functional areas that must be successfully integrated to bring a biotechnology product to market, this book presents a roadmap and reference for biotechnology operations, integrating the functional areas through the processes of product planning and design and the practice of project management. It also applies lessons gleaned during past decades as novel products have been developed from emerging scientific discoveries. The lessons highlight development principles and practices that could reduce risk, resolve problems, and help the industry to bring safe and effective biotechnology products of the future to market more efficiently and quickly.

Pedagogical Features: • Provides an introduction to each key biotechnology development subject in one volume • Incorporates an integrated approach, tying together the various functional areas • Emphasizes the need to both plan and integrate a program and provides the information with which to successfully lead such efforts • Uses relatively simple language, explains jargon, and uses diagrams to describe processes so subjects are easily understood

Catalog no. K11486, March 2011, 416 pp.

ISBN: 978-1-4398-3027-7, $99.95 Also available as eBook

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Abridged Contents: Introduction to Biotechnology Operations: Planning for Success Biotechnology Operations Marketing, Financial and Business Considerations for Development Product Development Planning Summary of Planning for Success Project Management Project Management in Biotechnology Background of Project Management Project Management in Biotechnology Project Management in Biotechnology Operations Project Management with Contracts and Collaborations Tools for Effective Project Management Summary of Project Management in Biotechnology Development Regulatory Affairs The U.S. Food and Drug Administration: Law and Regulations for Biopharmaceuticals FDA-Regulated Products U.S. FDA Regulatory Information and Resources: Regulatory Intelligence Regulatory Operations for FDA Applications Summary on Regulatory Affairs Activities in Biotechnology Operations Regulatory Compliance Regulatory Compliance Quality Systems to Meet Regulatory Compliance Compliance for Biopharmaceuticals: Other Regulations of Importance Quality Systems Biomanufacture Quality Control Nonclinical Studies Clinical Trials Glossary Additional Reading Practical Problems and Questions

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Biotechnology

Healthcare Biotechnology A Practical Guide Dimitris Dogramatzis Dogramatzis Pharmacy, Athens, Greece

"... particularly strong... provides insight into the biotechnology business sector."

—British Journal of Biomedical Science

It is a mammoth task to bring a biotechnology innovation from inception to widespread therapeutic use. It takes strong managerial skills and a solid grounding in biopharmaceutical research and development procedures to foresee and plan for all of the possibilities and pitfalls involved.

Healthcare Biotechnology: A Practical Guide focuses on the management of healthcare-related biotech—from product conception through regulatory approval and the rest of its life cycle.

Divided into easily digestible sections, the book covers current systems, recent progress and controversy, major players and products, and comparisons with the pharmaceutical industry. It covers topics including: • Intellectual property protection and management • The innovation cycle • Patent application • Commercialization and competition • Funding • Partnering • Cash-intensive activities • Financing alternatives • Complexities of alliance implementation and management Highlighting research, development, and biomanufacturing, it examines clinical trial design and regulations, "fast-track" approvals, and patient recruitment, as well as production platforms and processes, costs, strategies, and timelines. The author investigates marketing, including planning, promotion, pricing, supply chain management, and bio-brand lifecycle management. He concludes with tips on running the business, offering diverse biobusiness models and reasonable expectations, from inception through maturity and decline.

Catalog no. K12108, December 2010, 689 pp.

ISBN: 978-1-4398-4746-6, $104.95 Also available as eBook

Pedagogical Features: • Provides problems and essays for each subject covered • Includes a list of abbreviations and a business plan outline • Presents challenging chapter-end questions and exercises to inspire critical thinking • Contains hundreds of illustrations, tables, figures, references, and helpful appendices Solutions manual and more than 1000 PowerPoint® slides available with qualifying course adoption

Abridged Contents: The Healthcare Biotechnology Industry Bioeconomy Intellectual Property Intellectual Property Management Biolicensing Funding Biofinance Biopartnering New Product Development Biodrug Research Biomanufacturing Marketing Biomarketing Planning Biopromotion Biopricing Biosupply Chain Biobrand Life Cycle Management Running the Business Biobusiness Models Biocompany Life Cycle Appendices

For more information and complete contents, visit www.crctextbooks.com

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Biotechnology

Environmental Microbiology for Engineers Volodymyr Ivanov Nanyang Technological University, Singapore

Environmental Microbiology for Engineers examines how microbiology can be used in environmental research and practical applications.

Written for senior undergraduate to graduate level civil and environmental engineering students, this textbook encompasses both fundamental and applied principles and covers topics such as the microbiology of water, wastewater, soil, and air biotreatment systems used in environmental engineering. It also covers civil engineering topics such as biocementation, biocorrosion, biofouling and biodeterioration of materials.

The book provides a thoroughly up-to-date introduction to current trends in environmental microbiology and engineering. Microbial classification is represented as a periodic table with theoretical connections between all prokaryotic groups and highlighting their environmental applications. Combining microbiological knowledge and environmental biotechnology principles in a readable fashion, the text includes topics such as: • Structures and functions of microbial cell and cell aggregates • Applied microbial genetics and molecular biology • Diversity and function of microorganisms in environmental engineering systems • Environmental bioengineering processes • Microbiological monitoring of environmental engineering systems • Microbiology of water and wastewater treatment • Biocementation and bioc logging of soil • Biocorrosion of constructions • Biodeterioration of materials • Biopollution of indoor environment Catalog no. 92340, November 2010, 438 pp.

ISBN: 978-1-4200-9234-9, $104.95 Also available as eBook

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Pedagogical Features: • Combines microbiological knowledge and environmental biotechnology principles in a readable fashion • Discusses “hot” topics in the area such as environmental bionanotechnology, microbial geotechnology, and environmental engineering of closed microbial ecosystems • Teaches with minimal use of mathematical equations • Supplies a quiz and tutorial questions at the end of each chapter • Contains a glossary of terms Solutions manual available with qualifying course adoption

Abridged Contents: Stages of Bioprocessing Bioagents of Bioprocessing Microbial Metabolism and its control Molecular Biology and Genetics of Microorganisms Selection of Pure Cultures Classifications and Identifications of Prokaryotes Periodic Table of Physiological Groups of Prokaryotes Nutrition and Growth Cultivation of Microorganisms and Downstream Processes Microbial Adaptations and Engineering Control Microbial Natural Ecosystems Microbial Engineering Ecosystems Public Health Microbiology for Engineers Microbiology of Water Treatment Microbiology of Aquatic Ecosystems Microbiology of Anaerobic Wastewater Treatment Microbiology of Aerobic Wastewater Treatment Microbiology of Solid Wastes Biotreatment Microbiology of Soil Bioremediation Microbiology of Exhaust Gases Biotreatment Biocorrosion, Biodeterioration and Biofouling

Request your Complimentary eBook or Print Exam Copy at www.crctextbooks.com

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Biotechnology Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery Paul C.H. Li Simon Fraser University, Burnaby, British Columbia, Canada

Lab-on-a-chip technology now permits us to make many important discoveries that can only be observed at the microscale or the nanoscale.

The newest advances employed in biological and biochemical analysis translates into greater sensitivity, more accurate results, and more valuable findings. Authored by one of the field’s pioneering researchers, Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery focuses on all key aspects of the microfluidic lab-on-a-chip technologies to offer an exceptionally cohesive overview of the science, its limitations, breakthroughs made over the years, and currently emerging advances.

The book emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays, and enzymatic assays.

Pedagogical Features: • Reviews fundamentals of micromachining and fluid flow and control for lab-on-a-chip • Emphasizes analytical applications of microfluidic technology • Contains tables that summarize related materials • Provides problem sets that test students’ comprehension of the material • Includes a glossary, extensive references, and a four-page color insert Solutions manual available with qualifying course adoption

Catalog no. K10977, February 2010, 418 pp.

Soft Cover, ISBN: 978-1-4398-1855-8, $99.95 Also available as eBook

Systems Biology and Bioinformatics A Computational Approach Kayvan Najarian, Christopher N. Eichelberger, Siamak Najarian, and Shahriar Gharibzadeh Emphasizing computational methods, Systems Biology and Bioinformatics: A Computational Approach provides an introduction to system biology and its impact on biology and medicine.

It reviews basic principles of molecular and cell biology using a system-oriented approach, with a brief description of the high-throughput biological experiments that produce databases. The methods presented include techniques to discover genes, perform nucleotide and amino acid sequence matching, and estimate static gene dynamic pathways. It also explains applications for system-oriented models to predict the behavior of biological systems.

Catalog no. 46500, April 2009, 190 pp.

ISBN: 978-1-4200-4650-2, $75.95 Also available as eBook

Colloids and Interfaces in Life Sciences and Bionanotechnology Second Edition Willem Norde Wageningen University, The Netherlands, and University Medical Center Groningen, The Netherlands

Colloids and Interfaces in Life Sciences and Bionanotechnology is a classroom-tested reference that presents a concise introductory treatment of the physicochemical principles that determine interrelated colloidal and interfacial phenomena and their relevance to various life sciences. The book examines the spontaneous assembly of amphiphilic molecules and the intentional fouling of surfaces for the immobilization of cells in bioreactors. It also devotes special attention to reversible and soft colloids, discusses the colloidal domain in a historical perspective, and reviews the size and distribution of particles, electrokinetic phenomena.

Catalog no. K10890, June 2011, 495 pp.

ISBN: 978-1-4398-1718-6, $129.95 Also available as eBook

For more information and complete contents, visit www.crctextbooks.com

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General Textbooks A First Course in Differential Equations, Modeling, and Simulation Carlos A. Smith and Scott W. Campbell

Technical Writing A Practical Guide for Engineers and Scientists Phillip A. Laplante

University of South Florida, Tampa, USA

The Pennsylvania State University, Malvern, USA

Emphasizing a practical approach, A First Course in Differential Equations, Modeling, and Simulation avoids overly theoretical explanations and shows students how differential equations arise from applying basic physical principles and experimental observations to engineering systems. It also covers classical methods for obtaining the analytical solution of differential equations and Laplace transforms. The authors discuss how these equations describe mathematical systems and how to use software to solve sets of equations where analytical solutions cannot be obtained.

Using simple physics, the book introduces dynamic modeling, the definition of differential equations, two simple methods for obtaining their analytical solution, and a method to follow when modeling. It then presents classical methods for solving differential equations, discusses the engineering importance of the roots of a characteristic equation, and describes the response of first- and second-order differential equations. A study of the Laplace transform method follows with explanations of the transfer function and the power of Laplace transform for obtaining the analytical solution of coupled differential equations.

Written by a renowned engineer and widely published technical author, Technical Writing A Practical Guide for Engineers and Scientists teaches students how to write, edit, and publish materials of a technical nature, including books, articles, reports, and electronic media. Drawing on his own work, the author presents many first-hand examples of writing, editing, and publishing technical materials. These examples illustrate how a publication originated, challenges writers encounter, and various solutions.

Catalog no. K11106, July 2011, 250 pp.

Soft Cover, ISBN: 978-1-4398-2085-8, $39.95 Also available as eBook

Random Phenomena Fundamentals of Probability and Statistics for Engineers

Pedagogical Features:

Babatunde A. Ogunnaike

• Teaches how to model engineering systems

University of Delaware, Newark, USA

Solutions manual available with qualifying course adoption

Many of the problems that engineers face involve randomly varying phenomena. But even such randomness and the resulting uncertainty are subject to rigorous mathematical analysis.

Random Phenomena: Fundamentals of Probability and Statistics for Engineers provides students with a fundamental understanding of random phenomena and a working knowledge of how to model and analyze such phenomena. Explaining how to use probability and statistics to confront uncertainty in engineering problems, Dr. Ogunnaike bases his approach on the principle of theoretical foundations before application.

Catalog no. K12318, May 2011, 345 pp.

ISBN: 978-1-4398-5087-9, $89.95 Also available as eBook

Catalog no. 44974, September 2009, 1056 pp.

ISBN: 978-1-4200-4497-3, $139.95 Also available as eBook

• Reviews the necessary physics material • Explores how to obtain the analytical solution of differential equations using actual physical systems • Discusses how the roots of the characteristic equation provide the qualitative nature of the response of any system • Explains how to use simulation software • Provides numerical values in all examples and problems

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